il modello di singer and nicholson - didatticaweb 2.0 · mosaico fluido + + figure 10-12 molecular...
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Figure 10-1 Molecular Biology of the Cell (© Garland Science 2008)
IL MODELLO DI SINGER AND NICHOLSON
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Figure 10-19 Molecular Biology of the Cell (© Garland Science 2008)
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IL MODELLO DI SINGER AND NICHOLSON MOSAICO fluido
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Figure 10-35 Molecular Biology of the Cell (© Garland Science 2008)
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Figure 10-11 Molecular Biology of the Cell (© Garland Science 2008)
Mosaico FLUIDO
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Figure 10-12 Molecular Biology of the Cell (© Garland Science 2008)
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Figure 10-5 Molecular Biology of the Cell (© Garland Science 2008)
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Il doppio strato lipidico mostra un diverso grado di fluidità nelle diverse membrane e (nella membrana plasmatica) anche all’interno della stessa membrana.
Questo causa una diversa mobilità delle proteine intrinseche nel piano della membrana, funzionale al ruolo fisiologico della membrana stessa.
I fattori che influiscono (a parità di temperatura, pH e pressione) sulla fluidità del doppio strato sono i rapporti:
Colesterolo/Glicerofosfolipidi Catene aciliche sature/insature Proteine/Lipidi
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Parton and Simons Nature Reviews Molecular Cell Biology 8, 185–194 (March 2007) | doi:10.1038/nrm2122
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Figure 10-13 Molecular Biology of the Cell (© Garland Science 2008)
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1. STRUTTURA DELLA MEMBRANA
1. Funzioni principali della membrana 2. Modelli proposti e validità del modello di S&N 3. Modi in cui sono ancorate le proteine al doppio strato 4. Principali funzioni delle proteine di membrana 5. Principali componenti lipidici del doppio strato 6. Concetto di fluidità di membrana e fattori che la influenzano 7. I “raft” di membrana 8. Altre disimmetrie della membrana
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J = - DA ΔC/ΔX
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J = - DA ΔC/ΔX
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Trasporto facilitato: canali e trasportatori
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Trasporto facilitato: canali e trasportatori
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GlpF: omologo di E. Coli
AqpZ: omologo di E. Coli
AQP3 Dotto collettore (basolaterale), pelle, occhio,
vie respiratorie
AQP7: tessuto adiposo AQP9: epatociti
AQP1: tubulo prox., ansa discendente, vasa recta discendente
AQP6: Dotto cellettore
(secrezione acida?)
AQP0: occhio
AQP4: cervello
AQP5: ghiandole secretorie
(sudoripare, lacrimali, salivari,
delle vie respiratorie)
AQP2: dotto collettore (apicale)
AQUAPORINE
AQUAGLICEROPORINE
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