8/18/2019 ILAR Subtype

1/1

ILAR

subtype

Peak

age of

onset

F: M

ratio

% of

all JIA

cases

Arthritis

pattern

Extra

articular

features

Lab

in!estigations

"otes on

therapy

Systemic

arthritis

1-5 1:1 5-15 Polyarticular,

often aecting

knees, wrists and

ankles; also

ngers, neck andhips

aily fe!er;

e!anescent

rash;

pericarditis,

pleuritis

"nemia; #$% &

&;

'S( && ; %(P &&

;

ferritin &;platelets

&& )normal or *

in

+"S

ess responsi!e

to standard

treatment with

+./ and

anti-.0 agents;consider

2-1 or 2-3

inhi4itors in

resistant cases

or as

rst-line therapyligoarthri

tis

6-7 8:1 79-59 nees

,ankles, ngers

89= of cases

"0" positi!e in

>39=; other test

results usually

normal; may ha!e

mildly & 'S(?%(P

0S"2s and

intra-articular

steroids; +./

occasionally

re@uiredPolyarthrit

is

(-

negati!e

6-7 A

19-17

8:1 A

19:1

69-85 Symmetric?"sym

metric, small and

large Boints;

cer!ical spine;

 .+C

19= of cases

"0" positi!e in

79=;

( negati!e;

'S( & or & &;

%(P &?normal;

mild anemia

Standard

therapy with

+./

and 0S"2s;

then, if

nonresponsi!e,

anti-.0

agents or other

4iologics,

including

a4atacept,

indicated as

rst-line

therapyPolyarthrit

is

(-

positi!e

D-16 D:1 E19 "ggressi!e

symmetric

polyarthritis

(heumatoid

nodules in

19=, low

grade fe!er

( positi!e; 'S(

&&;

%(P & ?normal;

mild

anemia

ong-term

remission

unlikely;

early aggressi!e

therapy is

warranted

Psoriatic

arthritis

6-7 A

D-11

6:1 5-19 "symmetric

arthritis of small

or medium-siFed Boints

19=;

Psoriasis in59=

"0" positi!e in

59=; 'S( &;

%(P &?normal;mild anemia

0S"2s and

intraarticular

steroids; +./,anti-.0

agents'nthesitis

related

arthritis

D-16 1:G 5-19 Predominantly

lower lim4 Boints

aected;

sometimes aHial

skeleton

"cute antI

reacti!e

arthritis and

inJammatory

4owel

disease

K9= of patients

positi!e for

L"-$6G

0S"2s and

intra-articular

steroids;

consider

sulfasalaFine as

alternati!e

to +./; anti-

 .0 agents