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Immunization Action Coalition • (651) 647‐9009 • www.immunize.org • www.immunize.org/catg.d/S8005.pdf • Item #S8005 (8/19) 1
Adolescent Immunization Updateand the 16-year-old Platform
Sharon G. Humiston, MD, MPHAssociate Director for ResearchImmunization Action Coalition
Deborah L. Wexler, MDExecutive DirectorImmunization Action Coalition
August 2019・Item #S8005
Overview
• 16-year-old adolescent immunization platform
• Adolescent immunization rates
• Vaccination recommendations & updates
• Wrap up
ImmunizationPlatforms
Benefits of Immunization Platforms
• Ensure we give our patients all their recommended vaccines, and if not done earlier, catch them up on any vaccines they may have missed
• Using the 16-year-old platform
– Helps ensure that vaccines recommended at age 16 are given while the patients are still covered by public or private insurance
– Benefit of creating the opportunity to provide
• Developmentally targeted care and
• Anticipatory guidance
5Auslander B et al. J Adolescent Health 2017;60:475-6.
“Dear Colleague” or “Call to Action” Letter
Signed by:
• AAFP
• AAP
• ACHA
• ACOG
• APhA
• IAC
• SAHM
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www.immunize.org/catg.d/p4022.pdf www.immunize.org/catg.d/p4022.pdf
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www.immunize.org/catg.d/p4022.pdf www.immunize.org/catg.d/p4022.pdf
www.immunize.org/catg.d/p4022.pdf www.immunize.org/catg.d/p4022.pdf
IAC has a lot of handouts on these topics.Here’s how to find them. www.immunize.org
IAC has a lot of handouts on these topics.Here’s how to find them. www.immunize.org
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Adolescent Immunization Rates
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www.healthypeople.gov/2020/topics-objectives/ topic/immunization-and-infectious-diseases/objectives
Estimated coverage with selected vaccines and doses among adolescentsage 13–17 years, by survey year and ACIP recommendation—National Immunization Survey-Teen, United States, 2006–2017
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Estimated coverage with selected vaccines and doses among adolescentsage 13–17 years, by survey year and ACIP recommendation—National Immunization Survey-Teen, United States, 2006–2017
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Tdap
Estimated coverage with selected vaccines and doses among adolescentsage 13–17 years, by survey year and ACIP recommendation—National Immunization Survey-Teen, United States, 2006–2017
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Tdap
HPV dose 1
Estimated coverage with selected vaccines and doses among adolescentsage 13–17 years, by survey year and ACIP recommendation—National Immunization Survey-Teen, United States, 2006–2017
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Tdap
HPV dose 2
HPV dose 1
Estimated coverage with selected vaccines and doses among adolescentsage 13–17 years, by survey year and ACIP recommendation—National Immunization Survey-Teen, United States, 2006–2017
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MenACWYdose 1
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Immunization Action Coalition • (651) 647‐9009 • www.immunize.org • www.immunize.org/catg.d/S8005.pdf • Item #S8005 (8/19) 6
Estimated coverage with selected vaccines and doses among adolescentsage 13–17 years, by survey year and ACIP recommendation—National Immunization Survey-Teen, United States, 2006–2017
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MenACWYdose 1
MenACWYdose 2
MeningococcalDisease and Vaccines
Meningococcal Disease
Relatively rare – In 2017, there were ~350 cases of meningococcal disease reported (all serogroups)
Large toll
• Invasive meningococcal disease: 10%–15% patients die, even with antibiotic treatment
• Meningococcemia: up to 40% die
• Among survivors: Up to _____ sustain lifelong disability such as arm or leg amputation, hearing loss, or neurologic damage
33 MMWR 2013;62(RR-2):15; MMWR 2015;64:608-12
Meningococcal Disease
Relatively rare – In 2017, there were ~350 cases of meningococcal disease reported (all serogroups)
Large toll
• Invasive meningococcal disease: 10%–15% patients die, even with antibiotic treatment
• Meningococcemia: up to 40% die
• Among survivors: Up to _____ sustain lifelong disability such as arm or leg amputation, hearing loss, or neurologic damage
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20%
MMWR 2013;62(RR-2):15; MMWR 2015;64:608-12
Two Types of Meningococcal Vaccines
• Meningococcal Serogroup ACWY Vaccines (MenACWY)
– Available since 2005
– ACIP routine recommendations• In 2005 – Routinely recommended at age 11−12
• In 2010 – Booster dose recommended at age 16
35 MMWR 2013;62(RR-2):15; MMWR 2015;64:608-12
Two Types of Meningococcal Vaccines
• Meningococcal Serogroup ACWY Vaccines (MenACWY)
– Available since 2005
– ACIP routine recommendations• In 2005 – Routinely recommended at age 11−12
• In 2010 – Booster dose recommended at age 16
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• Meningococcal Serogroup B Vaccines (MenB)
– Available since late 2014
– ACIP routine recommendations• In 2015 – Routinely recommended for people at increased risk
age >10 years
• Later in 2015 – “May be given” to healthy persons 16 to 23 years of age, preferred at 16−18
MMWR 2013;62(RR-2):15; MMWR 2015;64:608-12
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W
C A
Y
There is currently no vaccine that contains all 5 serogroups
B
BMeningococcal ACWY Vaccine (MenACWY)
www.immunize.org/askexperts/experts_meningococcal_acwy.asp
MenACWY Vaccination
• Two brands
– Menactra (Sanofi Pasteur)
– Menveo (GlaxoSmithKline)
• Routine schedule
– 1st dose: Recommended at age 11–12 years
– 2nd dose (booster): Recommended at age 16 years
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Routine Recommendations
Risk-based Recommendations
www.immunize.org/catg.d/p2018.pdf
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Good vaccines
Bad disease
Ugly rates of vaccine series completion
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How can we make a change for the better?
Good vaccines
Bad disease
Ugly rates of vaccine series completion
Just updated! www.Give2MenACWY.org
• New website design
• Highlights importance of:
– Booster dose ofMenACWY vaccine
– ALL recommendedvaccines for 16-year-olds
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www.Give2MenACWY.org
Meningococcal Serogroup BVaccine(MenB)
www.immunize.org/vis/vis_meningococcal_b.asp
MenB Vaccination
• Two brands
– Bexsero (GlaxoSmithKline)
– Trumenba (Pfizer)
• Schedule for the primary series
– For healthy people – 2-dose schedule
✓ Bexsero: >1 month apart
✓ Trumenba: 6 months apart
– For high-risk people
✓ Bexsero: 2 doses >1 month apart
✓ Trumenba: 3-dose schedule (0, 2, 6 months)
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MenB primary series – More on scheduling
• Minimum intervals between doses have not been defined; use only the routine schedule
• MenB vaccines can be given at the same time as other vaccines, including MenACWY and all other vaccines that are indicated the 16-year-old visit
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MenB vaccines are NOT interchangeable
• The same vaccine must be used for all doses in the series
• If a person got a dose of both vaccines, pick one and complete the routine series with that brand
• The dose of the other brand of vaccine will NOT count as part of the series
66MMWR 2015;64(No.41):1171-76
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For whom is MenB recommended?
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• Routine (formerly Category A) for persons age 10 or older at high risk:– Functional or anatomic asplenia
– Persistent complement component deficiency, including people taking eculizumab (Soliris)
– At risk during an outbreak caused by a vaccine serogroup, such as on college campuses
– Microbiologists who work with meningococcus bacteria in a laboratory
• Shared Clinical Decision-Making (formerly Category B)
– ACIP recommends a MenB primary series for individuals aged 16–23 years based on shared clinical decision-making
– Preferred age of vaccination of 16 through 18 years
CDC will publish an updated statement
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• Will include new “shared clinical decision-making” language
• Will incorporate all existing ACIP recommendations for MenACWY and MenB vaccines into a single document
• Will include the new booster recommendations for high risk individuals
Watch for an announcement in IAC Express
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Routine Recommendations
Risk-based Recommendations
www.immunize.org/catg.d/p2035.pdf
MenB Vaccines ARE Covered by VFC & ACA
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Vaccines are included in the Vaccines For Children (VFC) program and the Affordable Care Act (ACA) if there is either kind of ACIP recommendation for them:
• Routine (for MenB high-risk groups)
• Shared Clinical Decision-Making (for healthy persons)
Both MenB vaccine formulations are covered for both high-risk persons (routine) and healthy persons (shared clinical decision-making)
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Tdap
www.immunize.org/photos/pertussis-photos.asp
Tdap Vaccines
• Tdap vaccines recommended by ACIP for persons >10
– Adacel (Sanofi Pasteur) for ages 10 through 64 years, can be used off-label for older individuals according to ACIP
– Boostrix (GlaxoSmithKline) for ages 10 years and older
• Everyone ages >11 should receive their first Tdap at the next visit if not done already
• Neither FDA-approved for persons <10, but ACIP recommends use as young as age 7 in some cases
• Both approved for a single dose currently
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www.cdc.gov/mmwr/volumes/67/rr/rr6702a1.htm
April 2018 – Prevention of Pertussis, Tetanus, and Diphtheria with Vaccines
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Tdap in Pregnancy
• Administer a dose of Tdap vaccine during each pregnancy, regardless of the woman’s prior history of receiving Tdap
• Optimal timing of Tdap is between 27 and 36 weeks gestation – preferably earlier in the interval
• Tdap may be administered earlier in pregnancy if necessary (e.g., wound management)
– Not needed to give another dose during that pregnancy
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www.immunize.org/catg.d/p4250.pdf
Human PapillomavirusVaccine
Average numbers of HPV-related cancers per year by location, U.S.
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Cervix Vulva &Vagina
Anus &Rectum
Oropharynx Penis
Females
Males
Not Causedby HPV
www.cdc.gov/cancer/hpv/statistics/cases.htm
Average numbers of HPV-related cancers per year by location, U.S.
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Cervix Vulva &Vagina
Anus &Rectum
Oropharynx Penis
Females
Males
Not Causedby HPV
10,751 caused by HPV
(females)
www.cdc.gov/cancer/hpv/statistics/cases.htm
Average numbers of HPV-related cancers per year by location, U.S.
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Cervix Vulva &Vagina
Anus &Rectum
Oropharynx Penis
Females
Males
Not Causedby HPV
10,751 caused by HPV
(females)
10,725 caused by HPV
(males)
www.cdc.gov/cancer/hpv/statistics/cases.htm
HPV Vaccine Recommendations – Ages
• Recommended age: 11–12 years
• Earliest age: 9 years
• Catch-up: 13–26 years; ACIP recommends that people who begin the HPV series at or before age 26 years may complete it at age 27 years or older
• Adults: Shared clinical decision-making for persons 27 through 45 years of age
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MMWR. 2016;65(49);1405–8
MMWR. 2019;68(32);698–702
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HPV Vaccination Schedule
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• 2-dose series suffices if started before the 15th
birthday (6–12 months between doses)
• 3-dose series if started on/after 15th birthday or immunocompromised in relevant way (1–2 months between doses #1 & #2; 6 months doses #1 & #3)
• If there is a long delay between doses #1–2 or #2–3, you do not have to restart the series.
• For more details, see the schedule atwww.cdc.gov/vaccines/schedules/hcp/imz/child-adolescent.html
Increase HPV Vaccination Rates
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• Low coverage has been a persistent problem
• In clinical settings, communication is key
– Same way, on the same day as the other vaccines
– Announcement style
– For an 11-year old it might sound like this:
Today, Cole is due for 3 vaccines: Tdap, HPV vaccine, and a meningitis vaccine.
HPV Vaccine: Same Way, Same Day App
• Brief, interactive role-play simulation
• Designed to enhance healthcare professionals’ ability to introduce HPV vaccine and address hesitant parents’ concerns
• Developed by Academic Pediatric Association, American Academy of Pediatrics
• Free
• Available formobile devices:
– From the Google Play Storehttps://play.google.com/store/apps/details?id=com.kognito.hpv_immunization
– From the Apple iTunes Storehttps://itunes.apple.com/us/app/hpv-vaccine-same-way-same-day/id1356847181?mt=8
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www.immunize.org/resources/apps.asp
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InfluenzaVaccines
www.immunize.org/handouts/influenza-vaccines.asp
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Cumulative monthly influenza vaccination coverage estimates for US adolescents, NIS-Flu, 2017–18 season
www.cdc.gov/flu/fluvaxview/reportshtml/reporti1718/reporti/index.html
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Influenza Vaccination Recommendations 2019–2020
• Routine annual influenza vaccination for all persons aged >6 months
• Any licensed, recommended, and age-appropriate vaccine (nasal spray or injectable) should be used
• New VISs for both nasal spray and injectable flu vaccine will be available on immunize.org, in English and in translation
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www.immunize.org/catg.d/p4072.pdf
To be updated soon for 2019–2020 season
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www.immunize.org/shop
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3 Thoughts on Catch-upVaccination
3 Thoughts on Catch-Up Vaccination
1. Everything that can go wrong has gone wrong, so check the immunization record and give the missing vaccines
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3 Thoughts on Catch-Up Vaccination
1. Everything that can go wrong has gone wrong, so check the immunization record and give the missing vaccines
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2. Hepatitis B vaccine is often missed!
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3 thoughts on catch-up vaccination
1. Everything that can go wrong has gone wrong, so check the immunization record and give the missing vaccines
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2. Hepatitis B vaccine is often missed!
3. Hepatitis A deserves your attention, too.
– Catch-up vaccination of children and adolescents
– Persons with HIV infection
– An update on hepatitis A vaccination will be published
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WebinarWrap-up
www.immunize.org/catg.d/u6005.pdf
Summary of today’s webinar
• Establish a 16-year-old visit in your office to make sure these patients receive the vaccines they need
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Summary of today’s webinar
• Establish a 16-year-old visit in your office to make sure these patients receive the vaccines they need
• Practices should follow the ACIP immunization schedule and help families adhere to it
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Summary of today’s webinar
• Establish a 16-year-old visit in your office to make sure these patients receive the vaccines they need
• Practices should follow the ACIP immunization schedule and help families adhere to it
• The 11–12 and 16-year-old platforms provide opportunities to review and complete all needed vaccination while the vaccines are covered by public or private insurance
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Immunization Action Coalition • (651) 647‐9009 • www.immunize.org • www.immunize.org/catg.d/S8005.pdf • Item #S8005 (8/19) 17
Summary of today’s webinar
• Establish a 16-year-old visit in your office to make sure these patients receive the vaccines they need
• Practices should follow the ACIP immunization schedule and help families adhere to it
• The 11–12 and 16-year-old platforms provide opportunities to review and complete all needed vaccination while the vaccines are covered by public or private insurance
• Develop strategies using tools discussed today to improve adolescent vaccination rates in your healthcare setting
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Immunization Action Coalition Resources
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Subscribe to IAC Express, IAC’s weekly e-newsletter
• www.immunize.org/subscribe
Websites
• www.immunize.org (for HCP)
• www.Give2MenACWY.org (for HCP)
• www.vaccineinformation.org (for the public)
Acknowledgements
William L. Atkinson, MD, MPH
Laurel Wood, MPACoordinator for Public Health
This Photo by Unknown Author is licensed under CC BY-NC-ND
Thank you!
This Photo by Unknown Author is licensed under CC BY-NC-ND
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