immunogenetics 30 12-14
TRANSCRIPT
Learning Objectives
• By the end of this lecture……….we all should be able:– To appreciate the organization of immune system– Understand the disorders related to immune
system– Explain the underlying mechanisms of immune
disorders
Immunoglobulins• Papaine splits the immunoglobulin
molecule into three fragments.– Two similar, each containing an
antibody site capable of combining with a specific antigen antigen-binding fragment or Fab
– The Crystallizable fragment Fc
The immunoglobulin molecule is made up of four polypeptidechains:•Two light(L) 220 AA •Two heavy (H) 440 AAEach Fab fragment is composed of L chains linked to the amino-terminal portion of the H chains,Fc fragment is composed only of the carboxv-terminal portion of the H chain
HLA Associated DiseasesLocus of genes that encode for proteins on the surface of cells that are responsible for
regulation of the immune system in humans.