immunology last year final exam 2011
TRANSCRIPT
Immunology
Final Exam Questions / last year exam (summer semster 2011)
1) Which of those can stimulate apoptosis?
Answer: TNF
2) Which of these is not a cause of secondary immune deficiency?
Answer: Genetic disorders
3) The most common deficient antibody in CVID:
Answer: IgG
4) Which cell produces IL-12?
Answer: Macrophages
5) ALL of these drugs are immunosuppressive except:
Answer: Imiquimod
6) MHC restriction means:
Answer: T cells recognize peptides that are bound to self MHC molecules
7) Tetanus toxoid vaccine:
Answer: Artificial active immunity
8) Which of the following tumor antigens is a developmental protein?
Answer: Carcinoembryonic antigen
9) Bence Jones protein is a finding; this type of cancer affects:
Answer: Plasma cells
10) Cyclosporin blocks:
Answer: Calcineurin
11) Anti-horse serum antibodies cause:
Answer: Serum sickness
12) Aspirin inhibits:
Answer: Prostaglandin (cyclooxygenase pathway)
13) First test to check in transplantation:
Answer: ABO Compatibility
14) Which part of the HIV binds both CD4 & chemokine receptor?
Answer: gp120
15) In which stage of T cell development commitment to gamma delta lineageoccurs:
Answer: Double negative stage
16) Best stem cells source:
Answer: Cord blood
17) Mismatch:
Answer: Human Herpes Virus 8 lymphoma
18) Severest stage of T-cell depletion is associated with infection with:
Answer: M. avium
19) Disadvantage of using mouse monoclonal antibody:
Answer: Production of human anti-mouse antibodies
20) HER-2:
Answer: Breast Cancer
21) Low IgG and IgA, high IgM [Hyper-IgM syndrome]:
Answer: CD40 ligand mutation
22) HIV can attack:
Answer: Glial cells
23) Reduce risk of human anti-mouse antibodies production:
Answer: Use of chimeric and humanized antibodies
24) Oligoclonal bands in CSF electrophoresis that are not present in serumelectrophoresis is a strong finding of:
Answer: Multiple sclerosis
25) ALL (Acute Lymphoblastic leukemia):
Answer: Pre B cells
26) Complement deficiency that results in repeat infection caused by Neisseria:
Answer: C5-C9
27) Not involved in the respiratory burst:
Answer: Phospholipase C
28) Which association is false?
a. TH2 cell IL-6
b. Mast Cell IL-10
Answer: most probably “a”
29) MHC down-regulation activates:
Answer: NK cells
30) Case : eczema, low platelets, infection, and malignancy:
Answer: Wiskott-Aldrich syndrome
31) Used for detecting antibodies against donor HLA:
Answer: HLA cross matching
32) Which virus infection is associated with Burkitt's lymphoma?
Answer: EBV
33) The most difficult transplantation procedure and requires the best HLAmatching:
Answer: Bone marrow transplantation
34) Person had a rare pan-T-cell deficiency. In the FACS machine, which cellmarker will be the least in number?
Answer: CD3
35) How can we increase the cytokines' half-life in the body?
Answer: Adding PEG molecule
36) The gene that is related to cancer:
Answer: Oncogene
37) Cyclosporin and Tacrolimus are part of which class of drugs:
Answer: T cell signaling blockade
38) ALL are true about TCR EXCEPT:
Answer: Undergoes somatic hyper-mutation to get better-fit receptors
39) If we were to produce a drug that blocks Ag expression on MHC I, this drugshould interfere with:
Answer: TAP molecules
40) ALL about IgG are true EXCEPT:a) the source of child immunity up to 2 yearsb) transported through an active process to placentac) transported to the fetus in the last month of pregnancyd) bind to Fc receptors on the placenta
Answer: Not sure! ALL these seem to be true!
41) In Di George syndrome, the most affected part of the lymph node is:
Answer: Paracortex
42) ALL of the following can help in production of memory cell EXCEPT:
a) Binding of epitope of Class II MHC to B cell receptor.b) IL-2 productionc) CD28 and B7d) CD40 and CD40 Le) Cross linking of B-cells receptor with polymeric antigen.
Answer: a
43) Involved in the signaling of IL-2:
Answer: JAK5 + STAT1 + STAT3
44) Case: with cANCA:
Answer: Wegners' Granulomatosis
45) Case : Pain in the hand and the wrist + ESR (high) + CRP (high) + Rheumaticfactor; what’s the antibody involved in the pathogenesis of the disease?
Answer: IgM anti-IgG
46) Febrile non-hemolytic anemia:
Answer: Donor Abs against recipient neutrophils
47) Transplantation between individuals of same species:
Answer: Allogenic
48) Which of these causes Adult T cell lymphoma:
Answer: HTLV-1
49) B cell activation needs:
Answer: Ag and cytokines
50) Clinically useful as anti-IL-2 receptor:
Answer: Baciliximab
51) Celiac disease is associated with:
Answer: HLA-DQ2
52) Isn't associated with T cell signaling:
Answer: TdT
53) In which disease the serum contains anti-endomysial IgA:
Answer: Celiac disease
54) IgG can be expressed on the surface of a B-cell only when:a) Surface IgM is selected and the genes is switched to the gamma genesb) Gamma chain gene is selected following isotype switching and thedevelopment of memory cells.c) A naive cell is exposed to an antigen for the first time.d) Clonally selected B cell that recognize non peptide antigen.e) The question is wrong: one B-cell express only one heavy chain isotype.
Answer: b
55) Which one takes the longest time to develop after exposure to the antigen?
Answer: Contact dermatitis
56) TLR:
Answer: Used in recognition of G-ve bacteria
57) Case : 10-year-old child, lung & skin infection, staph. aureus with normal
PMNcount:a) complement deficiencyb) low Igs with absent B cellsc) low Igs with normal B cellsd) abnormal NBT test
Answer: d
58) A defect in the hypochlorus acid will affect:
Answer: The acidity of the lysosomes
59) Autoimmune diseases:
Answer: Show HLA association
60) Case: an immunologist developed a dye to detect a protein present ondeveloping T cells; which of the following will glow the most:
Answer: Thymus
61) When we do a cross match between donor's RBCs and recipient's serum wedo:
Answer: Indirect Coomb's test (IAT)
62) In MS, we have CD4+ involvement; which one is expected:a) IL-2, IL-4, IF-gammab) TGF-Bc) IFN-gamma, IL-2d) IL-4, IL-5e) IL-10
Answer: c
63) RAG-1 and RAG-2 are down-regulated in some stages of B-cell developme
nt,so that each B cell will only have one specificity. The underlying mechanism is:a) somatic hypermutationb) class switchingc) affinity maturationd) allelic exclusion
Answer: d
64) In which of the following actin is affected:
Answer: Wiskott-Aldrich syndrome
65) MHC class I and II share this characteristic:
Answer: Constitutively expressed by B-cells
66) C4:a) cleaves C5b) can be activated by the MBLc) C4a is the most potent anaphylatoxind) C1q can only activate C4
Answer: b
67) Which of these is used in active treatment of cancer?a) BCG vaccineb) radiationc) chemotherapyd) anti-CD20 antibodies
Answer: a
68) ALL of the following can happen when thymus independent antigen crosslink B cell receptor EXCEPT:a) It is the major principle of vaccine developmentb) Antigen processing and presentation will not take placec) Low affinity Abs are producedd) Only IgM antibodies are producede) Signaling through the B cell receptor can pass through
Answer: Not sure about it! Most probably the answer is “a”
69) Which one is not involved in B cell signaling?
Answer:
70) C1q:a) needs Ab bindingb) binds two CH2 of IgMc) binds one CH2 of IgG
Answer: most probably “a”
71) A molecule that is expressed on tumor cells and on normal tissue from whichthey arise:
Answer: Lineage-specific antigens
72) In Wegners' granulomatosis, antibodies form against:
Answer: Proteinase 3
73) Which of these is found on the high endothelial venules and leads toleukocytes slowing down and stoppage?
Answer: L-selectin
74) Case : a patient with various lung symptoms and has anti-glomeruli basementmembrane antibodies:
Answer: Goodpasture syndrome
75) Serum electrophoresis that shows a band in the gamma region reflecting amonoclonal immunoglobulin:
Answer: M. Myeloma
76) Case : A patient had a bone marrow transplant. After 2 to 3 days, hedeveloped diarrhea and symptoms related to the skin and liver. What type ofreaction is this?
Answer: HVGD