Impetigo

Mupirocin; (bacitracin and neomycin, are less effective.) numerous lesions or not responding to topical agents: oral antimicrobials effective against both S. aureus and S. pyogenes.

Impetigo

Folliculitis

Local measures such as saline compresses and topical antibacterials (e.g., mupirocin)

Furuncles and Carbuncles

Most furuncles: moist heat.

carbuncle, a furuncle with surrounding cellulitis or fever, or a furuncle located about the midface: an antistaphylococcal antibiotic (e.g., dicloxacillin). In a penicillin-allergic adult: clindamycin, or co-trimoxazole.

Patients with moderate to severe disease are best treated with initial parenteral therapy (e.g., vancomycin, linezolid, or daptomycin)

Erysipelas

Mild early: oral penicillin V (500 mg every 6 hours) or initial IM procaine penicillin (600,000 units once or twice daily). Erythromycin (250 to 500 mg orally every 6 hours) or other macrolides are suitable alternatives.

More extensive: hospitalization and parenteral aqueous penicillin G (2,000,000 units every 6 hours).

If differentiation from cellulitis is difficult: a PRP (nafcillin or oxacillin), a cephalo 1, or therapy against MRSA.

cellulitis

Outpatient: PRP (nafcillin or oxacillin), cephalo 1 MRSA is suspected: clindamycin, TMP-SMX, doxycycline or

minocycline + B-lactam (eg, amoxicillin), linezolid.

Inpatient:PRP, cephalo 1MRSA is suspected: vancomycin, linezolid, daptomycin,

clindamycin

Diabetic Ulcers

Mild: POcephalexin, dicloxacillin, clindamycin

Moderate to severe: IVclindamycin plus a cephalo 3, clindamycin plus a fluoroquinolone, piperacillin-tazobactam, carbapenem, ampicillin-sulbactam, ticarcillin-clavulanate.

Cutaneous Abscess

Diabetic Ulcers

Gastroenteritis

ciprofloxacin, ofloxacin, levofloxacin, norfloxacin

Azithromycin

Typhoid Fever

Gastroenteritis (nosocomial)

CNS Infections (Meningitis)

CNS Infections (Brain Abscess)

CNS Infections (Shunt Infection)

vancomycin plus either cefepime, ceftazidime, or meropenem

CNS Infections (Subdural Empyema, Epidural Abscess)

vancomycin plus cefepime or ceftazidime + metronidazole or meropenem

In spinal cases, anaerobic coverage is not required.

CNS Infections (Suppurative Intracranial

Thrombophlebitis)

vancomycin plus cephalo 3 or 4 + metronidazole or meropenem