implementation science basics€¦ · key implementation science terms innovation •the...
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IMPLEMENTATION SCIENCE INTRODUCTIONTAREN SWINDLE, PHD
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OBJECTIVES FOR THIS SESSION
Describe the language of
Implementation Science (IS).
Identify key elements of IS
designs.
Describe 3 applications of IS in
the nutrition education and behavior field.
@taren_swindle
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IMPLEMENTATION SCIENCE DEFINED
“ Implementation Science is the scientific study of methods to
promote the systematic uptake of research findings and other
evidence-based practice into routine practice, and, hence, to
improve the quality and effectiveness…”
-Eccles & Mittman, Implementation Science, 2006
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IS “IS” REALLY SOMETHING NEW?
Familiar Concepts
Formative Research
Contextual Assessment
Stakeholder Engagement
Theory-Driven Intervention
Process Evaluations
New(er) Concepts
Linking implementation outcomes to
health outcomes
Focus on testing manipulations to
implementation process
Comparing implementation approaches
on fidelity, costs, sustainability, etc.
Swindle, T., Curran, G. M., & Johnson, S. L. (2019).
@taren_swindle
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KEY IMPLEMENTATION SCIENCE TERMS
Innovation• The evidence-based “thing” you are trying to get
people/systems to do
Implementation Strategies
• Action taken to get people/systems to do the innovation
Implementation Context
• Setting for implementing the innovation; Inner and outer environmental factors influencing implementation
@taren_swindle
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WHAT WILL YOU “DO” TO GET PEOPLE TO USE THE “THING”?
- G. CURRAN
@taren_swindle
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IN THIS PICTURE…
@taren_swindle
Innovation
– the thing!
An
implementation
strategy
Context
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KEY IMPLEMENTATION SCIENCE OUTCOMES
Adoption • Initial uptake of the innovation
Fidelity• Quality or integrity of delivery of the
innovation
Sustainability• Continued use of the innovation;
integration into the context
Proctor, E., Silmere, H., Raghavan, R., Hovmand, P., Aarons, G., Bunger, A., ... & Hensley, M. (2011).
@taren_swindle
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WHICH IMPLEMENTATION STRATEGY (OR STRATEGIES) WILL PROMOTE ADOPTION, FIDELITY, AND
SUSTAINABILITY OF THE INNOVATION GIVEN FEATURES OF THE CONTEXT?
@taren_swindle
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THEORIES, MODELS, AND FRAMEWORKS
Theories
• Propose causal mechanisms
• Imply prediction
• Classic and Implementation
Models• Propose guidance for implementation process
• Provide research to practice steps/strategies
Frameworks• Propose factors that could influence
implementation
• Determinant and evaluation
Nilsen, P. (2015)
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OPPORTUNITIES IN IS FOR NUTRITION EDUCATION & BEHAVIOR
Swindle, T., Curran, G. M., & Johnson, S. L. (2019).
@taren_swindle
Apply Implementation Science
- Choose implementation strategies based on context.
Integrate Implementation Science Approaches in Research
- Measure implementation outcomes and delivery of implementation strategies.
Contribute to Implementation Science Knowledge
- Conduct comparative effectiveness implementation trials.
- Test implementation theories.
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ILLUSTRATION OF IMPLEMENTATION SCIENCE TODAY
@taren_swindle
Do model-suggested strategies outperform a standard implementation for improving implementation and child outcomes?
Do stakeholder-selected strategies outperform a standard implementation for improving implementation and child outcomes?
What determinants influence implementation outcomes at three levels: client, provider, and organization ?
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Applying Implementation Science Theories, Models, and Frameworks to Study Go NAPSACC in KentuckyAmber Vaughn
July 29, 2019
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Funding
NIH, NHLBI, R01HL137929
CDC, U48DP005017
The content is solely the responsibility of the authors and does not
necessarily represent the official views of any funders.
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Overview
Outcomes
• Quality
Implementation
Framework
• Consolidated
Framework for
Implem. Research
• REAIM
Type 3 hybrid
with RCT
DesignTheory/
Strategies
Go NAPSACC
The Thing
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Go NAPSACC
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Go NAPSACC
PURPOSE
Support improvements to child
care environments that foster
healthy eating, physical activity,
and overall development in
children
Original NAPSACC = delivered to
child care programs in person by
NAPSACC Consultant using
paper-based tools
Go NAPSACC = translated tools
into interactive online format,
streamlined support required
from NAPSACC Consultant
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Go NAPSACC
PURPOSE
Support improvements to child
care environments that foster
healthy eating, physical activity,
and overall development in
children
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Go NAPSACC
PURPOSE
Support improvements to child
care environments that foster
healthy eating, physical activity,
and overall development in
children
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Common Barriers to Implementation
Variation in background/experience of Go NAPSACC Consultants
Unable to convert child care programs to active users
Lack of adherence to 5-step improvement process
Lack of director motivation
Lack of engagement of child care staff
Turnover in program management
Lack of opportunities for peer learning to share ideas
Lack of funding
Benjamin 2007, Ward 2008, Battista 2014, Martin 2015, Dinkel 2018
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Theories, Models, and Frameworks
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Summative Articles
Tabak et al. (2012) Bridging Research and Practice: Models for
Dissemination and Implementation Research. Am J Prev Med.
Identify theories and frameworks commonly used in dissemination and
implementation research
61 models identified
Nilsen (2015) Making Sense of Implementation Theories, Models and
Frameworks. Implem Sci.
Purpose/use of theories:
How should we implement the innovation?
What will influence the success of implementation?
How do we evaluate implementation success?
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How to ImplementHow do we improve Go NAPSACC implementation to address common barriers?
Quality Implementation Framework (QIF)
Synthesis of implementation literature
Critical steps for high-quality implementation
Four phases
Meyers 2012
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Quality Implementation Framework
Assessment,
Adaptation,
Capacity
Building
Applying
Lessons
Learned
Ongoing
Implementation
Support
Creating
Structure for
Implementation
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Local technical assistance
Quality Implementation Framework
Phase 4● Participate in cross-center team
meetings to share experiences and
learn from other centers
Phase 3● Implement Go NAPSACC
● Use online tools work through
two cycles of the 5-step
improvement process
Phase 2● Facilitate center capacity building
(general and intervention specific)
● Develop a plan for Go NAPSACC
implementation
Phase 1● Identify staff for implementation team
● Assess needs, fit, and capacity/
readiness
● Identify needed adaptations
Assessment,
Adaptation
Applying
Lessons
Learned
Ongoing
Implementation
Support
Capacity
Building,
Plan for
Implementation
Identify/prepare
champions
Assess readiness/
barriers
Conduct educational
outreach visits
Tailor content to address
priority needs
Formal
implementation
blueprint
Formal
commitment
FacilitationRemindersImplementation team meetings
*Powell BJ et al. (2015) A refined compilation of implementation strategies: results from the Expert Recommendations for
Implementing Change (ERIC) project. Implem Sci.
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What Influences ImplementationWhat contextual factors may be barriers or facilitators to Go NAPSACC implementation?
Consolidated Framework for Implementation Research (CFIR)
Outer setting
Inner setting
Individuals involved
Innovation characteristics
Implementation process
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Consolidated Framework for Implementation Research
Inner Setting
● Communication
● Culture
● Implementation climate
● Readiness
Individuals Involved
● Knowledge and beliefs
● Self-efficacy
EXAMPLES:
Communication: adequacy of efforts using
formal or informal methods for two-way
communication between admin, staff, and
families
Knowledge and beliefs: Staff are
knowledgeable about how to support healthy
eating and physical activity; they believe these
efforts are worthwhile
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How to Evaluate Implementation
How do we identify and evaluate important implementation outcomes?
RE-AIM
Adoption
Number
Representativeness
Implementation fidelity
Efficacy
Maintenance
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Research Design
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Study Design
Type 3 hybrid effectiveness-implementation trial with a cluster-randomized design.
Participants:
18 Child Care Aware Coaches
97 Child Care Centers, 1 director and 1 teacher from each
485 Children, about 5 per center, 3-4 years old, at two timepoints
Randomize coaches following baseline data collection
Basic Go NAPSACC or Enhanced Go NAPSACC
Implement Basic or Enhanced Go NAPSACC for 12 months
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Outcomes
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Implementation Outcomes
Centers’ implementation of evidence-based nutrition and physical
activity practices (assessed via EPAO)
Centers’ successful completion of key steps of Go NAPSACC
participation (assessed via website use)
Registration
Self-assessment
Setting goals and creating action plans
Completing action plans
Completing trainings
Repeating the self-assessment
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Implementation Outcomes (cont.)
Coaches’ successful delivery of key components of their assigned
implementation approach, Basic or Enhanced (assessed via TA
Activity log on website)
Centers’ and coaches’ perspectives of the implementation context
(assessed via survey)
Cost of implementation from the perspective of Child Care Aware
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Health Outcomes
Children’s diet quality for meals and snacks eaten at child care
Children’s physical activity at child care
Children’s BMI
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Project Team
PI = Dianne S. Ward, EdD
Co-Investigators = Alice Ammerman, Geoffrey Curran, Derek Hales,
Byron Powell, Christina Studts, Justin Trogden, Amber Vaughn
Project Managers = Regan Burney, Julie Jacobs
Community Partners = Child Care Aware of Kentucky, Kentucky
Department for Public Health
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SELECTING IMPLEMENTATION STRATEGIES WITH
STAKEHOLDER INPUTTAREN SWINDLE, PHD
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DISCLOUSURES
Funding NIH K01 DK110141-04
NIGMS P20GM109096
NIH NIDDK R03 DK117197-01
Arkansas Biosciences Institute
Lincoln Health Foundation
The content is solely the responsibility of the authors and does not necessarily represent the official views of the funding agencies.
Financial InterestsDr. Taren Swindle and UAMS have a financial interest in the technology (WISE) discussed in this presentation/publication. These financial interests have been reviewed and approved in accordance with the UAMS conflict of interest policies.
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OVERVIEW
WISE
The Thing integrated
Promoting Action on Research Implementation in Health Services
i-PARIHS
Theory
Multi-faceted bundle with 7 discrete strategies
Strategies
Re-AIM
Child Health
Outcomes
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THE THINGTOGETHER, WE INSPIRE SMART EATING
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THE “THING”
Evidence
Based Practice
Behaviors References and Guidelines
Engaging
mascot
- Uses mascot during activity.
- Leads chant with mascot.
Borzekowski & Robinson, 2001; Boyland, Harrold, Kirkham,
&Halford, 2012; Kraak &Story, 2015;Keller et al., 2012; Roberto,
Baik, Harris, & Brownell, 2010; Weber, Story, & Harnack, 2006
Multiple, hands-
on exposures
- Completes lesson in prescribed
group size.
- Involves children in lesson.
Anzman-Frasca, Savage, & Marini, 2012; Knai, Pomerleau, Lock, &
McKee, 2006; Office of Head Start, n.d.; Schindler, Wardle,
Cooke, & Gibson, 2003; Wardle & Herrera, 2003
Role Modeling - Eats food with the children.
- Makes positive comments about
the target food.
Gibson & Kreichauf, 2012; Greenhalgh, Dowey, & Horne, 2009;
Hendy & Raudenbush, 2000; Neelon & Briley, 2011; Office of
Head Start, n.d.
Positive feeding
practices
- Cues hunger and satiety.
- Encourages food exploration.
- Supports without pressure.
Birch, McPheee, & Shoba, 1987; Galloway, Fiorito, Francis, &
Birch, 2006; Johnson & Birch, 1994; Mustonen, Rantanen, &
Tuorila, 2009; Neelon & Briley, 2011; Office of Head Start, n.d.;
Reverdy, Chesnel, Schlich, Köster, & Lange, 2008
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WISE RESULTS
Sustained improvements in educator
knowledge
Outperformed standard for improving
child diet (FFQ)
Improvements supported by
biomarker measure
Whiteside-Mansell L., Swindle, T., In Press; Whiteside-Mansell L., Swindle, T., 2018; Whiteside-Mansell L., Swindle, T,. 2017
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THE THEORYI-PARIHS
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THE IMPLEMENTATION THEORY FRAMEWORK
Innovation
Recipient
Facilitation
i-PARIHS Framework
Context
SuccessfulImplementation
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RESEARCH QUESTION AND DESIGN
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THE RESEARCH QUESTIONS
Will stakeholder-selected strategies outperform a basic implementation approach on implementation and child outcomes?
• What barriers and facilitators do stakeholders prioritize?
• What strategies do stakeholders see as most feasible and important to address prioritized barriers and facilitators?
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THE RESEARCH DESIGN
Cluster, Randomized Hybrid III Trial
• Evidence-Based Quality Improvement Panels
• Concept Mapping
• Liberating Structures
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EVIDENCE-BASED QUALITY IMPROVEMENT
Rubenstein L, Stockdale S, Sapir N, Altman L, 2014; Curran GM, Mukherjee S, Allee E, Owen RR, 2008
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• Rate most important barriers and facilitators
Set priorities
• Link priorities to possible ERIC strategies
Map to Possible Strategies • Rate potential
strategies on importance & feasibility
Concept Mapping
• Gather feedback to improve
Present draft materials
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THE BARRIERS & FACILITATORS PRIORITIZED
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Context
• Leadership Support
• Capacity & climate for change
Innovation
• Time
• Perception of fit & advantage
Recipients
• Classroom Skills
• Beliefs
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CONCEPT MAPPING
Powell, B. J., Beidas, R. S., Lewis, C. C., Aarons, G. A., McMillen, J. C., Proctor, E. K., & Mandell, D. S., 2017
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IMPLEMENTATION STRATEGIESMULTIFACETED PACKAGE
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THE STRATEGIES SELECTED
1. Obtain formal commitments.
2. Develop an implementation blueprint.
3. Remind implementers.
4. Identify and prepare champions.
5. Facilitation
6. Develop educational materials.
7. Alter incentive structures.
Powell, B. J., Waltz, T. J., Chinman, M. J., Damschroder, L. J., Smith, J. L., Matthieu, M. M., ... & Kirchner, J. E. (2015); Waltz, T. J., Powell, B. J.,
Matthieu, M. M., Damschroder, L. J., Chinman, M. J., Smith, J. L., ... & Kirchner, J. E. (2015).
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THE MULTI-FACETED IMPLEMENTATION STRATEGY
@taren_swindle
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THE STRATEGIES SPECIFIED: EXAMPLES
Strategy Actor Action Temporality Dose Justification
Identify &
prepare
champions
Volunteer or
designated at
each enhanced
site
Provide 3 hour
training in how to
advocate, educate,
and navigate for WISE
Within 2
months of
teacher
training
One-time
training with
facilitator
contacts
Provide local
contact to
increase capacity
for change.
Incentives Classroom
teacher pairs
will receive
incentives (i.e.,
classroom
supplies) from
WISE staff
Provide tailored
incentives reflective
of use of 4 key
practices.
Educators can
earn new
incentives
each quarter
Varies by
teacher (0 – 8
incentives may
be earned)
Increase likelihood
educators will try
WISE practices &
create first-hand
experience with
advantages;
leverage social
norms.Proctor, E. K., Powell, B. J., & McMillen, J. C. (2013). Implementation strategies: recommendations for specifying and reporting. Implementation Science, 8(1), 139.
@taren_swindle
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OUTCOMESIMPLEMENTATION AND HEALTH
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THE IMPLEMENTATION OUTCOMES
Construct Measures
Reach Number of Lessons delivered
Effectiveness Child Food Frequency; Child BMI; Child RRS scan
Adoption Food purchase records; Organizational Readiness for
Implementing Change1
Implementation WISE fidelity, Acceptability, Feasibility2
Maintenance Fidelity in following school year
@taren_swindle
1. Shea, C. M., Jacobs, S. R., Esserman, D. A., Bruce, K., & Weiner, B. J. (2014).
2. Weiner, B. J., Lewis, C. C., Stanick, C., Powell, B. J., Dorsey, C. N., Clary, A. S., ... & Halko, H. (2017).
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RESULTSPRELIMINARY!
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QUALITATIVE FEEDBACK
“I was very pleased with how they would come out
to the center and talk with me to see if there was
anything I needed. They went to the classrooms to
check on the teachers to see how things were
going… I just couldn’t believe how they just tagged
on to us ….I just don’t think there was anything
lacking that we didn’t get here that we needed or I
needed.”
– Center director
“When we had our teacher meeting, I had
them watch the videos. And they got some
stuff from the videos. I liked the videos y’all
sent. I got to learn more stuff and then pass it
on to them .”
– WISE Champion
“She came back and gave the other classes
a reward. We did all this and you still gave
us a bad report? Nah. Something is wrong
with this picture.”
- Assistant Teacher
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PRELIMINARY QUANTITATIVE RESULTS
$215 per classroom to deliver enhanced support for one year
Significant treatment effects for:
Fidelity to Role Modeling
Fidelity to Engaging Mascot
Marginal treatment effects for:
Fidelity to Hands-On Exposure
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Disseminating and Implementing a
Lifestyle-based Healthy Weight Program
for Mothers in a National Organization
July 29, 2019
Rachel Tabak, PhD, RDWashington University in St. Louis
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Disclosures
Funding R18DK089461 R01HL143360 R01DK121475 Washington University Center for Diabetes Translation Research
(P30DK092950) Washington University Institute of Clinical and Translational Sciences (UL1
TR000448) Washington University, Institute for Public Health, Center for
Dissemination and Implementation Pilot Program
The content is solely the responsibility of the authors and does not necessarily represent the official views of the funding agencies.
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HEALTH
The Thing
Consolidated Framework For Implementation Research
RE-AIM (Reach, Effectiveness, Implementation, Adoption, Maintenance)
Theory Develop and distribute HEALTH educational materials
Make parent educator training dynamic
Provide ongoing consultation
Strategies
RE-AIM
Mom’s weight
Outcomes
Overview
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The Things (i.e., innovation or evidence-based
intervention)
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Partnership with Parents as Teachers
In 2016-2017, PAT served: 190,000 families
227,000 children
Parents as Teachers Program locator (March 2019)
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History of our 20 year partnership with PAT
High 5 Low Fat
1998-2001
High 5 for Kids
2001-2005
BALANCE2005-2011
LIFE-Moms2011-2018
HEALTH2011-2018
HEALTH D&I2018-2023
LIFE-Moms D&I
2019-2024
Context assessment pilot
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Healthy Eating & Active Living Taught at Home
(HEALTH)
Embedded lifestyle intervention
Within curriculum for Parents as Teachers
Simplified content – dietary behaviors most likely to impact weight
Mothers (n=179) of preschool children with overweight or obesity
Haire-Joshu. American journal of preventive medicine 54.3 (2018): 341-351.R18DK089461, Haire-Joshu P(I)
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Maternal Weight Change over 24 Months in HEALTH
Effectiveness Trial by Randomization Assignment
Haire-Joshu et al, Am J Prev Med 2018;54(3):341
2.1
3.2
-0.7
-1.5
-2
0
2
4
Baseline 12-month 24-month
Wei
ght
Ch
ange
(kg
)
Months after randomzation
Standard PAT PAT+HEALTH
R18DK089461, Haire-Joshu P(I)
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HEALTH Dissemination & Implementation
Research design: Cluster randomized
28 sites (532 moms) nationwide
Randomized: HEALTH or Usual care
Effectiveness on weight and behaviors (e.g., soda intake)
Mother, sites, parent educators
Implementation outcomes (RE-AIM)
Context (CFIR)
Tabak. Implementation Science 14.1 (2019): 68.R01HL143360, Tabak (PI)
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The Implementation theory frameworks
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The Implementation theory frameworks: RE-AIM (Reach,
Effectiveness, Implementation, Adoption, Maintenance)
https://www.frontiersin.org/articles/10.3389/fpubh.2019.00064/full
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The Implementation theory frameworks: Consolidated
Framework For Implementation Research (CFIR)
Co
reC
om
po
nen
ts
Ad
ap
tab
le P
eri
ph
ery
Outer Setting
Inner Setting
Intervention(unadapted)
Intervention(adapted)
Process
Individuals
Involved
Co
reC
om
po
nen
ts
Ad
ap
tab
le P
erip
hery
https://implementationscience.biomedcentral.com/articles/10.1186/1748-5908-4-50
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Understanding implementation context
10 site leaders and 6 parent educators in 8 states
Semi-structured interviews and a survey
Positive perspectives of LIFE-Moms
Recommended materials be highly visual, low literacy, Spanish
Flexibility to tailor to family’s needs and context
Prefer virtual training to avoid travel
Tabak. Health Behavior and Policy Review (2019), 5(5), 77-89.
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Implementation strategy
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HEALTH Training Curriculum
Develop and distribute HEALTH educational materials
Make parent educator training dynamic
Provide ongoing consultation
Tabak. Implementation Science 14.1 (2019): 68.
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Implementation outcomes
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RE-AIM Outcome Definition Level
Reach/Representativeness
Absolute number, proportion, and representativeness of individuals who participate in HEALTH
• PAT site
EffectivenessImpact of HEALTH on weight and important lifestyle behaviors (e.g., diet and activity)
• Individual participant
Adoption Intention, initial decision, or action to try or employ HEALTH; ‘‘uptake’’ • PAT site
Appropriatenessa Perceived fit, relevance, and compatibility of HEALTH for PAT and parent educators; and perceived fit of HEALTH to address weight
• Parent educator
Feasibilitya Extent to which HEALTH can be successfully used or carried out within a given agency or setting
• Parent educator
Implementation
Acceptabilitya Perception among implementation stakeholders that HEALTH is agreeable, palatable, or satisfactory
• Individual participant• Parent educator• PAT site
FidelityDegree to which HEALTH was implemented as prescribed in the original protocol or as it was intended by the program developers
• Parent educator
Adaptationa Planned or purposeful changes and unintentional deviations to the design or delivery of HEALTH
• Parent educator
Maintenance/Sustainability
Extent to which HEALTH is maintained or institutionalized within PAT’s ongoing, stable operations
• PAT site• PAT National Center
aIncludes qualitative measures
Tabak. Implementation Science 14.1 (2019): 68.
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Acknowledgements
Thanks to: Ross Brownson, Debra Haire-Joshu, Stephanie Mazzucca, Enola Proctor, Cindy Schwarz, Ronni Byrth, Allison Kemner, Allie Phad, Shelly Johnston, Brad Evanoff, Jaime Strickland, and Washington University Network for D&I Research (WUNDIR)
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Resources for D&I research
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Textbooks
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https://cancercontrol.cancer.gov/IS/tools/practice.html
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D&I Resources
Washington University in St. Louis - DIRC toolkits
Intro to D&I, Aims, Barriers & Facilitators, Implementation Outcomes, Designs, Implementation Organizational Measures, Implementation Strategies, Guidelines, Checklist for writing IR proposals
https://sites.wustl.edu/wudandi/di-toolkits/
Veteran Affairs’ Quality Enhancement Research Initiative
http://www.queri.research.va.gov/implementation/quality_improvement/default.cfm
National Cancer Institute’s Implementation Science Team
http://cancercontrol.cancer.gov/is/
Canadian Knowledge Translation Clearinghouse website
http://ktcanada.net/
Grid-Enabled Measures developed by the National Cancer Institute
https://www.gem-beta.org/public/MeasureList.aspx?cat=2
Training Institute on Dissemination and Implementation Research (TIDIRH), National Institutes of Health
https://obssr.od.nih.gov/training/training-supported-by-the-obssr/training-tidirh/
ACCORDS – University of Colorado
http://www.ucdenver.edu/academics/colleges/medicalschool/programs/ACCORDS/sharedresources/DandI/Pages/Resources.aspx
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NIH Funding Opportunities
Dissemination and Implementation Research in Health
R01 PAR-19-274
R21 PAR-19-275
R03 PAR-19-276
Standing study section