improper scaling of reference ct images in the 3d match environment

8/21/2019 Improper Scaling of Reference CT Images in the 3D Match Environment

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Varian P/N CP-05007 Rev C page 1 of 20

URGENT MEDICAL DEVICE CORRECTION

URGENT FIELD SAFETY NOTICE

Subject: Improper scaling of reference CT images in the 3D

Match environment.

Commercial Name of Affected Product: OBI 1.3, OBI 1.4; OBI 1.5; TrueBeam 1.0; OfflineReview 1.0 - 2.0

Reference / FSCA Identif ier: CP-05007

Date of Noti fication: 2012-11-05

Type of Action: Notification and Correction

Details on Affected Devices: Refer to Appendix C/D.

Description of Problem:

This letter is to advise you of an anomaly that has been identified in the 3D Match environmentof OBI 1.3, OBI 1.4, OBI 1.5, TrueBeam 1.0 and Offline Review 1.0 – 2.0 when using referenceCT datasets which contain a critical number of slices. [Note that the 3D Match environments ofTrueBeam 1.5 and Offline Review 2.1 are not affected by this anomaly.] When these referenceCT datasets are used to create a reference CT volume in the 3D Match environment, in a smallnumber of cases, the scaling of the CT volume will be incorrect and the CT volume will appearlarger – in the slice direction - than it actually should be. If this improperly scaled CT volume isused for 3D matching, the CBCT volume and patient may be positioned too far superiorly.Because of differences in software design, OBI 1.5 is much more likely to exhibit this behaviorthan the other products identified in this notification. This notice provides a description of theissue, the actions you can take to avoid the issue, and steps Varian is taking to address theissue.

Background:

In the 3D Match environment the CT slices from a reference CT are converted into a CT volumefor display. To minimize use of computer memory, the CT volume is always representedinternally using 250 slices, even if the original CT dataset contains more slices. When CTdatasets with greater than 250 slices are used, internally the original CT slices are re-sampledso that only 250 slices exist in memory.

Details:

The problem lies in the logic used to determine when the re-sampling of the CT dataset shouldoccur. Due to flaws in the logic, on occasion the re-sampling will not be performed, even thoughthe original CT dataset contains more than 250 slices. The result will be a CT volume that isdisplayed as being larger in the slice direction than it should be (see Figure 1). There is nogeometric error at the inferior end of the CT volume and maximum geometric error at thesuperior end of the CT volume.


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Varian PN CP-05007 Rev C page 2 of 20

The anatomy within any slice is displayed properly. And any structures drawn on top of the CTvolume are also scaled properly. Therefore, it is possible to recognize this problem becausethere will be a mis-alignment between the CT volume and the structures in sagittal and coronal

views, although it may be difficult to detect the issue in the axial view.

The problem only occurs if (i) the slice spacing in the CT dataset is uniform throughout theentire CT dataset; (ii) the CT dataset contains a number of CT slices in a critical range (seeTable 1 and Appendix A); (iii) the CT dataset is used in conjunction with CBCT imageacquisition; and, (iv) the CT slices are ordered so that the CT slice with the smallest CT couchposition is the slice that reaches the scaling logic first. Because of these multip le factors, theprobability of encountering the problem is li kely small, but is very difficult to predict.

Figure 1: An improperly scaled reference CT showing a stretched CT volume. The structu res arescaled properly and are displayed accurately.

Affected CT Datasets:

Only CT datasets with the number of slices in a critical range are subject to the problem. If thenumber of CT slices in the dataset exceeds a certain value, which depends upon the slicethickness, then the CT volume is re-sampled properly, and no scaling problem appears. And noproblem occurs for CT datasets containing 250 or fewer CT slices. Therefore, the problem

THE PROBLEM:

The CT volume(gray-scale image) isstretched.The structures andCT volume are notaligned.


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exists only for CT datasets that contain a narrow range of CT slices. Table 1 shows that rangefor a number of slice thicknesses. Appendix A gives a more complete listing.

SliceThickness

Number ofSlices:

Lower Limit

Number ofSlices:

Upper Limit

Number of AffectedCT Slices

MaximumError[mm]

0.5 251 299 49 24.5

1.0 251 274 24 24.0

1.25 251 269 19 23.75

1.5 251 266 16 24.0

2.0 251 262 12 24.0

2.5 251 259 9 22.5

3.0 251 258 8 24.0

5.0 251 254 4 20.0Table 1: The size of CT datasets that are affected by the problem and the magnitude of themaximum error. CT datasets containing number of slices below the Lower Limit, or above theUpper Limit, will not be affected by the problem.

Magnitude of the Geometric Error:

The geometry of the CT volume is correct at the inferior end of the CT volume and themaximum error occurs at the superior end of the CT volume (see Figure 1). The error at anyintermediate location scales linearly with position relative to the ends. Therefore, the treatmentisocenter location - typically in the middle of the CT volume - would have an error 50% of the

maximum error.

The magnitude of the maximum scaling error for any CT dataset depends upon how manyslices above 250 that the CT dataset contains. The maximum scaling error (i.e., the error at thesuperior end of the CT scan) is given by "the number of slices in the CT dataset greater than250" times "the slice thickness". If the maximum scaling error becomes equal to, or larger than,25.0 mm, then the CT dataset is outside of the critical range where the error will occur. Themaximum scaling error for some slices is listed in Table 1 and a more complete list is in

Appendix A.

Error (at superior end) = (Number of slices in CT dataset – 250) * slice thickness. (Eq. 1)[for Error < 25 mm]Error (at superior end) = 0 if number of slices = 25 mm

The magnitude of the maximum scaling error as a function of slice number, and for selectedslice thicknesses, is shown in Figure 2.


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Figure 2: Error at the superior end of the CT dataset as a function of number of CT slices in the CTdataset for (left-to-right ) 3.0 mm, 2.5 mm, 2.0 mm and 1.0 mm slice th icknesss.

Ordering of the CT Slices:

The order in which the CT slices are sent to the 3D Match environment is important. The scalingproblem occurs only if the first slice from the CT dataset reaching the 3D Match environment isthe CT slice with the smallest CT couch position. With any other slice order, no scaling problemwill occur, even though the CT dataset contains the number of CT slices in the critical range.The slice order depends upon the product and software version, as well as clinical practice.

OBI 1.5

In OBI 1.5, the order that the CT slices is received by the 3D Match environment is thesame as the order in which the CT slices are saved in the database. The database is notdesigned to store CT slices in a defined order, so the exact order of saving andretrieving CT slices cannot be predicted. However, empirical examination of severaldatabases shows that the probability that the CT slice with the smallest couch positionbeing loaded first ranges between 1/5 – 1/2. This number appears to depend uponclinical practice, and it is speculated that the CT slice order is related to the direction theCT table is moving when the CT dataset is acquired. As a result, 1/5 – 1/2 of the CTdatasets that contain the critical number of CT slices may exhibit the scaling problem.


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The scaling problem will also appear in the OBI 1.5 3D Match environment every timethe CT dataset is loaded and used.

OBI 1.3, OBI 1.4, Offline Review 1.0, 1.1, 1.2, 1.3, 2.0 and TrueBeam 1.0

In these products, the loading of the CT slices goes through an intermediate step wherethe CT slices are placed in a cache before being sent to the 3D Match environment. Theorder that CT slices are accessed from the cache is random. Therefore, the probabilitythat the CT slice with the smallest couch position being loaded first is 1/(number ofslices), which is ~ 1/250. Therefore, there is a much lower probability that the scalingproblem will be encountered with these product versions. Furthermore, because theordering of the CT slices is random, the problem may appear one day and not appearsubsequently.

Recommended User Actions

Review your clinical matching process. If you do not use the CT volume (gray-scale image) formatching but overlay the structures on top of the acquired CBCT, then this scaling problem willnot affect you. This is because the structures have the proper dimensions.

Stop using CT datasets in the critical CT slice range. Use the information in Table 1 or Appendix A to determine the critical CT slice range for the CT slice thicknesses that your clinic uses. Ifyou have any patients on treatment with a reference CT in the critical CT slice range, create anew CT volume in your treatment planning system using fewer CT slices and copy the existingplan to the new volume. If you use Eclipse as your treatment planning system, and are not

familiar with the process of reducing the number of slices in a CT volume, contact the VarianHelp Desk. For guidance, one method to reduce the number of CT slices in a CT volume isdescribed in Appendix B.

It is difficult to check if this problem has occurred with previous patients. While the probability isquite low with OBI 1.3, OBI 1.4, TrueBeam 1.0 and Offline Review 1.0 – 2.0, there is no way ofsystematically reviewing all matches to see if previous matches were in error.

If one is using OBI 1.5 then checks can be made using Offline Review, because the probabilityof a scaling problem occurring is different between the two products. Identify patients with CTdatasets where the number of CT slices is in the critical range. Load these patients into OfflineReview and first verify that there is no display problem in Offline Review by displaying a coronal

slice and comparing the body outline with the CT volume (e.g., see Figure 1). Examine the 3Dmatch. If the match appears correct in Offline Review, then the scaling problem is not likely tohave occurred in OBI 1.5. The error to look for is the CBCT dataset being positioned too farsuperiorly. Any checks in Offline Review are best done using sagittal and coronal views.


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Varian Actions:

Varian is notifying all possibly affected customers with this document. Varian is developing a correction for this issue for OBI 1.5. You will be contacted by a

Varian Service representative when this correction (OBI 1.5.17 or higher) is available toschedule its installation on your system.

Varian is developing a correction for this issue for OBI 1.4. You will be contacted by aVarian Service representative when this correction (OBI 1.4.14 or higher) is available toschedule its installation on your system.

OBI 1.3 software has reached its end-of-support [A letter entitled "End of supportannouncement for On-Board Imager® kV imaging system, version 1.3" dated 25 March2011 was sent to all OBI 1.3 customers]; therefore, Varian does not plan to develop acorrection for OBI 1.3. Contact your Varian service representative to arrange and

upgrade of your OBI 1.3 system to a more recent version of OBI. The upgrade from OBI1.3 to OBI 1.4 is available at no charge to all customers.

All TrueBeam 1.0 installations will be updated with TrueBeam 1.5 software. TrueBeam1.5 does not suffer from the issue described in this communication.

Please advise the appropriate personnel working in your radiotherapy department of thecontent of thi s letter. For future reference, this document will be posted to the Variancustomer support website: http ://www.MyVarian.com.

Special Instructions for customers outside the USA and Canada: In order to satisfyregulatory requirements, we request that you complete the attached Proof of Notification or

Receipt Verification Card once you have read this document and return it to Varian MedicalSystems.

We sincerely apologize for any inconvenience and thank you in advance for your cooperation. Ifyou require further clarification, please feel free to contact your local Varian Customer SupportDistrict or Regional Manager.

The undersigned confirms that this notice has been provided to the appropriate Regulatory Agency.

Mika MiettinenDirector, Global Quality Assurance and Product Reliability


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Varian Oncology Help Desk Contact Information:

Phone: USA and Canada – 1-888-VARIAN5 (888- 827-4265)

Europe - +41 41 749 8844

Email: North America: [email protected]

Australia/New Zealand: [email protected]

Europe: [email protected]

South East Asia: [email protected]

China / Asia: [email protected]

Japan: [email protected]

Latin America: [email protected]

Internet: Oncology Systems customer site - www.myvarian.com

Varian Medical Systems public site - www.varian.com


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Appendix A: The size of CT datasets that are affected by the prob lem

CT datasets containing number of slices below the Lower Limit, or above the Upper Limit, will

not be affected by the problem.

SliceThickness

Number ofSlices:

Lower Limit

Number ofSlices:

Upper Limit

Number of AffectedCT Slices

MaximumError[mm]

0.3 251 333 83 24.9

0.4 251 312 62 24.8

0.5 251 299 49 24.5

0.6 251 291 41 24.6

0.7 251 285 35 24.5

0.8 251 281 31 24.8

0.9 251 277 27 24.3

1.0 251 274 24 24.0

1.1 251 272 22 24.2

1.2 251 270 20 24.0

1.25 251 269 19 23.75

1.3 251 269 19 24.7

1.4 251 267 17 23.8

1.5 251 266 16 24.0

1.6 251 265 15 24.0

1.7 251 264 14 23.8

1.8 251 263 13 23.4

1.9 251 263 13 24.7

2.0 251 262 12 24.0

2.1 251 261 11 23.1

2.2 251 261 11 24.2

2.3 251 260 10 23.0

2.4 251 260 10 24.0

2.5 251 259 9 22.5

2.6 251 259 9 23.4

2.7 251 259 9 24.3

2.8 251 258 8 22.4

2.9 251 258 8 23.2

3.0 251 258 8 24.0

3.1 251 258 8 24.8

3.2 251 257 7 22.4

3.3 251 257 7 23.1

3.4 251 257 7 23.8


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3.5 251 257 7 24.5

3.6 251 256 6 21.6

3.7 251 256 6 22.2

3.8 251 256 6 22.8

3.9 251 256 6 23.4

4.0 251 256 6 24.0

4.1 251 256 6 24.6

4.2 251 255 5 21.0

4.3 251 255 5 21.5

4.4 251 255 5 22.0

4.5 251 255 5 22.5

4.6 251 255 5 23.0

4.7 251 255 5 23.5

4.8 251 255 5 24.0

4.9 251 255 5 24.5

5.0 251 254 4 20.0

6.0 251 254 4 24.0

7.0 251 253 3 21.0

8.0 251 253 3 24.0

9.0 251 252 2 18.0

10.0 251 252 2 20.0


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Appendix B: Creating a new 3D Image (CT volume)

This Appendix describes how to create a new 3D Image (CT volume) from an existing 3D Image

when Eclipse is used for treatment planning. This Appendix only needs to be reviewed if youcurrently have patients on treatment whose reference CT datasets fall into the critical range.

Please contact the Varian Help Desk if you need assistance with these instructions.

The following example shows how to generate a new 3D Image in Eclipse with a reduced number of CTslices. The scaling anomaly can be avoided by reducing the number of CT slices to 250 slices or less. Inthe example, there are 255 transverse images with a slice separation of 2 mm. The tumor volume lies inthe superior aspect of the lung. It is necessary to provide an accurate DVH for the lung structure, butthere are several transverse slices at the inferior aspect of the data set which lie far outside the anatomicregion of interest and would not affect the DVH or dose calculation to the critical and normal tissues.Therefore, these inferior CT slices may be excluded during the creation of a new CT volume.

1.) Go to Selection.

2.) Highlight the CT Series folder in the scope window and, while holding down the left mouse button,drag this object to the far right:

In "Selection" , highlight theplanning CT Series folder inthe scope window (at the

upper left) and drag it to thefar right, so that all of thetransverse images load to thegallery.


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As a result, all of the transverse images in the CT data stack will be loaded in the gallery:

3.) Only the transverse images open in the gallery will be utilized for the creation of the new 3D Image. By"closing" some slices, the number of CT slices used to form the 3D Image can be reduced.

Note: Only remove CT slices that will not affect planning properties such as DVHs or dose calculations.Furthermore, even if the slice thickness was varied during acquisition of the CT images, the 3D imagecreated will have a uniform slice thickness.

While holding down the left mouse button, drag the mouse over the slices in the gallery which the userhas determined can be excluded from the 3D image till they appear highlighted, then right mouse click(RMC) and select Close:

As a result , all o f the transverse images inthe CT data set are loaded to the gallery. Inthis case, a total of 255 CT slices.


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Note: Do NOT choose to delete these images.

4.) The slice count now in the gallery will be reduced. RMC on any remaining individual transversethumbnail and create a new 3D Image (CT volume):

While holding down the left mousebutton, highlight the individualtransverse images at the inferioraspect of the data stack. While theseslices are still highligh ted, RMC andselect "Close".

Now only 247 imagesappear in the gallery.RMC and create"New 3D Image".


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5.) In the ensuing 3D image creation dialog box, the user will confirm the resulting number of slices, aswell as the slice separation. A unique ID must be provided for this new 3D Image:

6.) In Eclipse versions 8.1 through 10, the new 3D Image will automatically be registered to the original3D (as seen in the focus window under the yellow Registered Images folder):

Verify the

resulting image countand plane separation(i.e., slice thickness).

Specify a unique ID for thisnew 3D image:

The new 3Dimage is

automaticallyregistered bythe system tothe original3D in Eclipseversions 8.1through 10.


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7.) In such instances, the user can skip Registration and proceed directly to Contouring . Drop theoriginal 3D Image to view, so that all of the original structures are visualized. RMC on the structure seticon (or on the original 3D Image, depending on the Eclipse software version) and select to copy the

structures:

8.) Drop the new 3D Image back to view (so it is now at the top of the focus window hierarchy), RMC andPaste Structure(s):

The original 3D image will be at the top o f thefocus w indow hierarchy. In Eclipse 8.1 through8.5, RMC on this 3D image>Copy>Struc tures.However, in Eclipse versions 8.6 through 10 (asshown), RMC on the struc ture set icon and select

“ Copy all Structures” .

The original 3D image is nowback at the top of the focuswindow hierarchy.


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In later versions, the user may be asked to provide a name for the newly pasted structure set.

Review the resulting structures to ensure correctness.

9.) Proceed to External Beam Planning (or the Field Setup Workspace, depending on the version ofEclipse) and drop the original plan to view.

10.) RMC on the existing plan>Copy Plan.

11.) RMC again on the same plan>Paste Plan or Paste Plan with Reference Images (depending onEclipse version). Provide a unique ID for this new plan.

12.) RMC on the newly pasted plan>Assign Patient Image (in versions 8.1 through 8.5) or >AssignStructure Set (in Eclipse versions 8.6 through 10). Depending on the Eclipse version, choose either the3D image or the structure set created in step 5 (or 8) from the Object Explorer Window. Once thisoccurs, the MU will be stripped from the plan. This is normal system behavior.

13.) If the institution uses the Set User Origin tool, this will NOT be preserved after associating the newplan to the new 3D image/structure set. Therefore, this step must be performed again. Check that theproper coordinates are utilized in the plan (as displayed in the Info Window at the bottom of the screen,as well as by examining the isocenter location on an orthogonal pair of DRR’s/fields in the BEV).

14.) In Eclipse versions 8.1 through 8.5, go to Planning>Dose Calculation>Calculate Volume withFixed MU’s. In Eclipse versions 8.6 through 10, go to Planning>Dose Calculation>Calculate Volumewith Preset Values.

15.) Verify that the MU’s, as well as the dose/fraction, prescribed percentage, and plan normalizationvalue are the same as per the original plan. If correct, click Apply:

Verify all parameters(including MU, theprescription,prescribed percentage,and plan normalizationvalue).


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The fields should be recalculated. When the calculation is complete, the above preset values dialog boxwill still appear, so click OK to close it.

Compare in Plan Evaluation the resulting dose distribution and dvh of this plan as compared to theoriginal plan. There may be slight MU/dose rounding. If there is a significant difference, then the user iscautioned to review the steps taken and/or to call the Eclipse Help Desk for further support, trouble-shooting, and evaluation. If no deviation is noted, then go back to External Beam Planning or the FieldSetup Workspace and change the number of remaining fractions to be delivered in the Info Window forthis newly pasted/recalculated plan. Then issue planning/treatment approval as usual. Also remember toComplete Early the original plan, so it will no longer be valid for treatment.

Note: During the calculation, the leaf motion calculator (LMC) should NOT re-run. If the user sees theleaf motion calculator dialog box (normally seen just after the optimization window closes), then abort theprocess. Do NOT let the LMC re-run or a leaf sequence can be generated which can be different thanthat which was originally QA’d. At this point, call the Eclipse Help Desk (as the additional stepsnecessary are outside the scope of this document).


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APPENDIX CLIST OF SERIAL NUMBERS

H080002 H080065 H080126 H080186 H080250 H080313 H080375 H080437 H080497 H080558 H080664 H080740 H082010

H080003

H080066

H080127

H080187

H080251

H080314

H080376

H080438

H080498

H080601

H080665

H080741

H082011

H080004 H080068 H080128 H080188 H080252 H080315 H080377 H080439 H080499 H080602 H080666 H080742 H082012

H080005 H080069 H080129 H080189 H080254 H080316 H080378 H080440 H080500 H080604 H080667 H080745 H082013

H080006 H080070 H080130 H080190 H080255 H080317 H080379 H080441 H080501 H080605 H080668 H080746 H082014

H080008 H080071 H080131 H080191 H080256 H080318 H080380 H080442 H080502 H080606 H080669 H080747 H082015

H080009 H080072 H080132 H080192 H080257 H080319 H080381 H080443 H080503 H080607 H080670 H080748 H082016

H080010 H080073 H080133 H080193 H080258 H080320 H080382 H080444 H080504 H080608 H080672 H080749 H082017

H080011 H080074 H080134 H080194 H080259 H080321 H080383 H080445 H080506 H080609 H080673 H080753 H082018

H080012 H080075 H080136 H080195 H080260 H080322 H080384 H080446 H080507 H080610 H080674 H080754 H082020

H080013 H080076 H080137 H080196 H080261 H080324 H080385 H080447 H080508 H080611 H080675 H080755 H082021

H080014 H080077 H080138 H080197 H080262 H080325 H080386 H080448 H080509 H080612 H080676 H080759 H082022

H080016 H080078 H080139 H080198 H080263 H080326 H080387 H080449 H080510 H080613 H080677 H080760 H082023

H080017 H080079 H080140 H080199 H080264 H080327 H080389 H080450 H080511 H080614 H080678 H080761 H082024

H080018 H080080 H080141 H080200 H080265 H080328 H080391 H080451 H080512 H080615 H080679 H080762 H082025

H080019 H080081 H080142 H080202 H080266 H080329 H080392 H080452 H080513 H080616 H080680 H080763 H082026

H080020 H080082 H080143 H080203 H080267 H080330 H080393 H080453 H080514 H080617 H080683 H080764 H082031

H080021

H080083

H080144

H080204

H080268

H080331

H080394

H080454

H080515

H080618

H080684

H080766

H082032

H080022 H080084 H080145 H080205 H080269 H080332 H080395 H080455 H080516 H080619 H080685 H080768 H082033

H080024 H080085 H080147 H080206 H080270 H080333 H080396 H080456 H080517 H080620 H080686 H080772 H082034

H080026 H080086 H080148 H080207 H080271 H080334 H080397 H080457 H080518 H080621 H080687 H080773 H082035

H080027 H080087 H080149 H080208 H080272 H080335 H080398 H080458 H080519 H080622 H080688 H080774 H082036

H080028 H080088 H080150 H080209 H080273 H080336 H080399 H080459 H080520 H080623 H080689 H080775 H082037

H080029 H080089 H080151 H080210 H080274 H080337 H080400 H080460 H080521 H080624 H080690 H080778 H082038

H080030 H080090 H080152 H080211 H080275 H080338 H080401 H080461 H080522 H080625 H080691 H080783 H082039

H080031 H080091 H080153 H080212 H080276 H080339 H080402 H080462 H080523 H080626 H080692 H080786 H082040

H080032 H080092 H080154 H080213 H080278 H080340 H080403 H080463 H080524 H080627 H080693 H080788 H082041

H080033 H080093 H080155 H080214 H080279 H080341 H080404 H080464 H080525 H080628 H080695 H080791 H082042

H080034 H080094 H080156 H080215 H080280 H080342 H080405 H080465 H080526 H080629 H080696 H080798 H082043

H080035 H080095 H080157 H080216 H080281 H080344 H080406 H080466 H080527 H080630 H080697 H080800 H082044

H080036 H080096 H080158 H080217 H080282 H080345 H080407 H080467 H080528 H080631 H080698 H080801 H082045

H080037 H080097 H080159 H080218 H080283 H080346 H080408 H080468 H080529 H080632 H080699 H080805 H082046

H080038 H080099 H080160 H080219 H080286 H080347 H080409 H080469 H080530 H080633 H080700 H080812 H082047

H080039

H080100

H080161

H080220

H080287

H080348

H080410

H080470

H080531

H080634

H080701

H080836

H082048

H080040 H080101 H080162 H080221 H080288 H080349 H080411 H080471 H080532 H080635 H080702 H080840 H082049

H080041 H080102 H080163 H080222 H080289 H080350 H080412 H080472 H080534 H080636 H080703 H080852 H082050

H080042 H080103 H080164 H080224 H080290 H080351 H080413 H080473 H080535 H080637 H080706 H080857 H082051

H080043 H080104 H080165 H080225 H080291 H080352 H080414 H080474 H080536 H080638 H080707 H080859 H082052

H080044 H080105 H080166 H080226 H080292 H080353 H080415 H080476 H080537 H080641 H080708 H080860 H082053

H080045 H080107 H080167 H080227 H080294 H080354 H080416 H080477 H080538 H080642 H080709 H080861 H082054

H080046 H080108 H080168 H080228 H080295 H080355 H080417 H080478 H080539 H080643 H080710 H080864 H082055

H080047 H080109 H080169 H080229 H080296 H080356 H080418 H080479 H080540 H080644 H080711 H080866 H082056

H080048 H080110 H080170 H080230 H080297 H080357 H080419 H080480 H080541 H080645 H080712 H080868 H082057

H080049 H080111 H080171 H080231 H080298 H080358 H080420 H080481 H080542 H080646 H080713 H080869 H082058

H080050 H080112 H080172 H080232 H080299 H080359 H080421 H080482 H080543 H080647 H080714 H080870 H082059

H080051 H080113 H080173 H080234 H080300 H080360 H080423 H080484 H080544 H080650 H080716 H080873 H082060

H080052 H080114 H080174 H080235 H080301 H080361 H080424 H080485 H080545 H080651 H080717 H080881 H082061

H080053 H080115 H080175 H080236 H080302 H080362 H080425 H080486 H080546 H080652 H080718 H081001 H082062

H080054 H080116 H080176 H080237 H080303 H080363 H080426 H080487 H080547 H080653 H080726 H082000 H082063

H080055

H080117

H080177

H080238

H080304

H080364

H080427

H080488

H080548

H080654

H080727

H082001

H082064

H080056 H080118 H080178 H080239 H080305 H080365 H080428 H080489 H080549 H080655 H080728 H082002 H082065

H080057 H080119 H080179 H080240 H080306 H080366 H080429 H080490 H080550 H080656 H080729 H082003 H082066

H080059 H080120 H080180 H080243 H080307 H080368 H080430 H080491 H080551 H080657 H080730 H082004 H082067

H080060 H080121 H080181 H080244 H080308 H080369 H080431 H080492 H080552 H080659 H080733 H082005 H082068

H080061 H080122 H080182 H080245 H080309 H080370 H080432 H080493 H080553 H080660 H080734 H082006 H082069

H080062 H080123 H080183 H080246 H080310 H080371 H080433 H080494 H080554 H080661 H080736 H082007 H082070

H080063 H080124 H080184 H080247 H080311 H080373 H080435 H080495 H080555 H080662 H080738 H082008 H082071

H080064 H080125 H080185 H080248 H080312 H080374 H080436 H080496 H080557 H080663 H080739 H082009 H082072


18/20




H082073 H082137 H082201 H082265 H082330 H082393 H082520 H082584 H082647 H082712 H082778 H082842 H082907

H082074 H082138 H082202 H082266 H082331 H082394 H082521 H082585 H082649 H082713 H082779 H082843 H082910

H082075 H082139 H082203 H082267 H082332 H082395 H082522 H082586 H082650 H082714 H082780 H082844 H082911

H082076 H082140 H082204 H082268 H082333 H082396 H082523 H082587 H082651 H082715 H082781 H082845 H082912

H082077

H082141

H082205

H082269

H082334

H082397

H082524

H082588

H082652

H082716

H082782

H082846

H082913

H082078 H082142 H082206 H082270 H082335 H082398 H082525 H082589 H082653 H082717 H082783 H082847 H082914

H082079 H082143 H082207 H082271 H082336 H082399 H082526 H082590 H082654 H082718 H082784 H082848 H082915

H082080 H082144 H082208 H082272 H082337 H082400 H082527 H082591 H082655 H082719 H082785 H082849 H082916

H082081 H082145 H082209 H082273 H082338 H082401 H082528 H082592 H082656 H082720 H082786 H082850 H082917

H082082 H082146 H082210 H082274 H082339 H082402 H082529 H082593 H082657 H082721 H082787 H082851 H082919

H082083 H082147 H082211 H082275 H082340 H082403 H082530 H082594 H082658 H082722 H082788 H082852 H082920

H082084 H082148 H082212 H082276 H082341 H082404 H082531 H082595 H082659 H082723 H082789 H082853 H082921

H082085 H082149 H082213 H082277 H082342 H082406 H082532 H082596 H082660 H082724 H082790 H082854 H082922

H082086 H082150 H082214 H082278 H082343 H082407 H082533 H082597 H082661 H082725 H082791 H082855 H082923

H082087 H082151 H082215 H082279 H082344 H082408 H082534 H082598 H082662 H082726 H082792 H082856 H082924

H082088 H082152 H082216 H082280 H082346 H082409 H082535 H082599 H082663 H082727 H082794 H082857 H082925

H082089 H082153 H082217 H082282 H082347 H082410 H082536 H082600 H082664 H082730 H082795 H082858 H082926

H082090 H082154 H082218 H082283 H082348 H082411 H082537 H082601 H082666 H082731 H082796 H082859 H082927

H082091 H082156 H082219 H082284 H082349 H082412 H082538 H082602 H082667 H082732 H082797 H082860 H082928

H082092 H082157 H082220 H082285 H082350 H082450 H082539 H082603 H082668 H082733 H082798 H082861 H082929

H082093 H082158 H082221 H082286 H082351 H082451 H082540 H082604 H082669 H082734 H082799 H082862 H082930

H082094 H082159 H082222 H082287 H082352 H082452 H082541 H082605 H082670 H082735 H082800 H082864 H082931

H082095 H082160 H082223 H082288 H082353 H082453 H082542 H082606 H082671 H082736 H082801 H082865 H082932

H082096 H082161 H082224 H082289 H082354 H082475 H082543 H082607 H082672 H082737 H082802 H082866 H082933

H082097 H082162 H082225 H082290 H082355 H082476 H082544 H082608 H082673 H082738 H082803 H082868 H082934

H082098 H082163 H082226 H082291 H082356 H082480 H082545 H082609 H082674 H082739 H082804 H082869 H082935

H082099 H082164 H082227 H082292 H082357 H082482 H082546 H082610 H082675 H082740 H082805 H082870 H082937

H082100 H082165 H082228 H082293 H082358 H082484 H082547 H082611 H082676 H082741 H082806 H082871 H082938

H082101 H082166 H082229 H082294 H082359 H082485 H082548 H082613 H082678 H082743 H082807 H082872 H082939

H082102 H082167 H082230 H082295 H082360 H082486 H082549 H082614 H082679 H082744 H082808 H082873 H082940

H082103 H082168 H082231 H082296 H082361 H082487 H082550 H082615 H082680 H082745 H082809 H082874 H082941

H082104 H082169 H082232 H082297 H082362 H082488 H082551 H082616 H082681 H082746 H082810 H082875 H082942

H082105 H082170 H082233 H082298 H082363 H082489 H082552 H082617 H082682 H082747 H082811 H082876 H082943

H082106 H082171 H082234 H082299 H082364 H082490 H082553 H082618 H082683 H082748 H082812 H082877 H082944

H082107 H082172 H082235 H082300 H082365 H082491 H082554 H082619 H082684 H082749 H082813 H082878 H082945

H082108 H082173 H082236 H082301 H082366 H082492 H082555 H082620 H082685 H082750 H082814 H082879 H082946

H082109 H082174 H082237 H082302 H082367 H082493 H082556 H082621 H082686 H082751 H082815 H082880 H082947

H082110 H082175 H082238 H082303 H082368 H082494 H082557 H082622 H082687 H082752 H082816 H082881 H082948

H082112 H082176 H082239 H082304 H082369 H082495 H082559 H082623 H082688 H082753 H082817 H082882 H082949

H082113 H082177 H082241 H082306 H082370 H082496 H082560 H082624 H082689 H082754 H082818 H082883 H082950

H082114 H082179 H082242 H082307 H082371 H082498 H082561 H082625 H082690 H082755 H082819 H082884 H082951

H082115 H082180 H082243 H082308 H082372 H082499 H082562 H082626 H082691 H082756 H082820 H082885 H082952

H082116 H082181 H082244 H082309 H082373 H082500 H082563 H082627 H082692 H082757 H082821 H082886 H082953

H082117 H082182 H082245 H082310 H082374 H082501 H082564 H082628 H082693 H082758 H082822 H082887 H082954

H082118 H082183 H082246 H082311 H082375 H082502 H082565 H082629 H082694 H082759 H082823 H082888 H082955

H082119 H082184 H082247 H082312 H082376 H082503 H082566 H082630 H082695 H082760 H082824 H082889 H082957

H082120 H082185 H082248 H082313 H082377 H082504 H082567 H082631 H082696 H082761 H082825 H082890 H082958

H082121 H082186 H082249 H082314 H082378 H082505 H082568 H082632 H082697 H082762 H082826 H082891 H082959

H082122 H082187 H082251 H082315 H082379 H082506 H082569 H082633 H082698 H082763 H082827 H082892 H082960

H082123 H082188 H082252 H082316 H082380 H082507 H082570 H082634 H082699 H082764 H082828 H082893 H082961

H082124 H082189 H082253 H082317 H082381 H082508 H082571 H082635 H082700 H082765 H082829 H082894 H082962

H082125 H082190 H082254 H082318 H082382 H082509 H082572 H082636 H082701 H082766 H082830 H082895 H082963

H082126 H082191 H082255 H082319 H082383 H082510 H082573 H082637 H082702 H082767 H082831 H082896 H082964

H082127 H082192 H082256 H082320 H082384 H082511 H082574 H082638 H082703 H082768 H082832 H082897 H082965

H082128 H082193 H082257 H082321 H082385 H082512 H082575 H082639 H082704 H082769 H082833 H082898 H082966

H082129 H082194 H082258 H082322 H082386 H082513 H082576 H082640 H082705 H082770 H082834 H082899 H082967

H082130 H082195 H082259 H082323 H082387 H082514 H082578 H082641 H082706 H082771 H082835 H082900 H082968

H082131 H082196 H082260 H082324 H082388 H082515 H082579 H082642 H082707 H082772 H082836 H082901 H082969

H082133 H082197 H082261 H082325 H082389 H082516 H082580 H082643 H082708 H082773 H082838 H082902 H082970

H082134 H082198 H082262 H082326 H082390 H082517 H082581 H082644 H082709 H082774 H082839 H082903 H082971

H082135 H082199 H082263 H082327 H082391 H082518 H082582 H082645 H082710 H082776 H082840 H082904 H082972

H082136 H082200 H082264 H082328 H082392 H082519 H082583 H082646 H082711 H082777 H082841 H082905 H082973


19/20




H082974 H083041 H083111 H083176 H083244 H083311 H083376 H083442 H083516 H083590 H083691 H191069

H082975 H083042 H083112 H083177 H083245 H083312 H083377 H083443 H083517 H083591 H083702 H191070

H082976 H083043 H083113 H083178 H083246 H083313 H083378 H083445 H083518 H083592 H084338 H191071

H082977

H083044

H083114

H083179

H083247

H083314

H083379

H083446

H083519

H083593

H191001

H191072

H082978 H083045 H083115 H083180 H083248 H083315 H083380 H083448 H083521 H083594 H191002 H191073

H082979 H083046 H083116 H083181 H083249 H083316 H083381 H083449 H083522 H083595 H191003 H191076

H082980 H083047 H083117 H083182 H083250 H083317 H083382 H083450 H083523 H083596 H191005 H191077

H082981 H083048 H083119 H083183 H083251 H083318 H083383 H083451 H083524 H083599 H191006 H191078

H082982 H083049 H083120 H083184 H083252 H083319 H083384 H083452 H083525 H083600 H191007 H191079

H082983 H083050 H083121 H083185 H083253 H083321 H083385 H083453 H083526 H083601 H191008 H191080

H082984 H083051 H083122 H083186 H083254 H083322 H083386 H083454 H083527 H083602 H191009 H191082

H082985 H083052 H083123 H083187 H083255 H083323 H083387 H083455 H083529 H083604 H191010 H191083

H082986 H083053 H083124 H083188 H083256 H083324 H083388 H083456 H083530 H083607 H191011 H191085

H082987 H083054 H083125 H083189 H083257 H083325 H083389 H083457 H083532 H083608 H191012 H191086

H082988 H083055 H083126 H083190 H083258 H083326 H083390 H083458 H083533 H083609 H191013 H191087

H082990 H083056 H083127 H083191 H083259 H083327 H083391 H083459 H083534 H083610 H191014 H191088

H082991 H083057 H083128 H083192 H083260 H083328 H083392 H083461 H083536 H083611 H191015 H191089

H082993 H083058 H083129 H083193 H083261 H083330 H083393 H083462 H083537 H083612 H191019 H191090

H082994 H083059 H083130 H083194 H083262 H083331 H083394 H083463 H083539 H083616 H191020 H191091

H082995

H083060

H083131

H083195

H083263

H083332

H083395

H083464

H083540

H083617

H191021

H191092

H082996 H083061 H083132 H083196 H083264 H083333 H083396 H083465 H083541 H083618 H191022 H191094

H082997 H083062 H083133 H083197 H083265 H083334 H083397 H083466 H083543 H083620 H191023 H191095

H082998 H083063 H083135 H083198 H083266 H083335 H083398 H083467 H083544 H083621 H191025 H191098

H082999 H083064 H083136 H083199 H083267 H083336 H083399 H083469 H083546 H083622 H191026 H191100

H083000 H083065 H083137 H083200 H083268 H083337 H083400 H083470 H083548 H083623 H191027 H191101

H083001 H083066 H083138 H083202 H083269 H083338 H083401 H083471 H083549 H083624 H191028 H191102

H083002 H083067 H083139 H083204 H083270 H083339 H083402 H083473 H083550 H083625 H191029 H191106

H083003 H083068 H083140 H083205 H083271 H083340 H083403 H083475 H083551 H083628 H191030

H083005 H083069 H083141 H083206 H083272 H083341 H083404 H083476 H083552 H083629 H191031

H083006 H083070 H083142 H083207 H083273 H083342 H083405 H083478 H083553 H083631 H191032

H083007 H083071 H083143 H083208 H083274 H083343 H083406 H083480 H083556 H083632 H191033

H083008 H083072 H083144 H083210 H083275 H083344 H083407 H083481 H083557 H083634 H191034

H083009 H083073 H083145 H083211 H083276 H083345 H083408 H083482 H083558 H083635 H191035

H083010 H083074 H083146 H083212 H083277 H083346 H083409 H083484 H083559 H083636 H191036

H083011 H083075 H083147 H083213 H083279 H083347 H083410 H083485 H083560 H083637 H191038

H083012

H083076

H083148

H083214

H083280

H083348

H083412

H083486

H083561

H083638

H191039

H083013 H083077 H083149 H083216 H083281 H083349 H083413 H083487 H083562 H083639 H191040

H083014 H083078 H083150 H083217 H083282 H083350 H083414 H083488 H083563 H083642 H191041

H083015 H083079 H083152 H083218 H083283 H083351 H083415 H083489 H083564 H083643 H191042

H083016 H083080 H083153 H083219 H083284 H083352 H083416 H083490 H083565 H083645 H191043

H083017 H083082 H083154 H083220 H083285 H083353 H083417 H083491 H083566 H083646 H191044

H083018 H083083 H083155 H083221 H083287 H083354 H083418 H083492 H083567 H083647 H191045

H083019 H083084 H083156 H083222 H083288 H083355 H083419 H083494 H083568 H083648 H191046

H083020 H083085 H083157 H083224 H083289 H083356 H083420 H083495 H083569 H083650 H191047

H083021 H083086 H083158 H083225 H083290 H083357 H083421 H083496 H083571 H083651 H191048

H083022 H083087 H083159 H083226 H083291 H083358 H083422 H083497 H083572 H083653 H191049

H083023 H083088 H083160 H083227 H083292 H083359 H083423 H083499 H083573 H083654 H191050

H083024 H083089 H083161 H083228 H083293 H083360 H083424 H083500 H083574 H083655 H191051

H083025 H083090 H083162 H083229 H083294 H083361 H083425 H083502 H083575 H083659 H191052

H083026 H083091 H083163 H083230 H083295 H083363 H083426 H083503 H083576 H083662 H191053

H083027 H083092 H083164 H083231 H083297 H083364 H083427 H083504 H083577 H083663 H191054

H083029 H083093 H083165 H083232 H083298 H083365 H083428 H083505 H083578 H083664 H191055

H083030 H083094 H083166 H083233 H083299 H083366 H083429 H083506 H083579 H083665 H191056

H083031 H083098 H083167 H083234 H083300 H083367 H083430 H083507 H083580 H083667 H191057

H083033 H083103 H083168 H083235 H083301 H083368 H083433 H083508 H083581 H083668 H191058

H083034 H083104 H083169 H083236 H083302 H083369 H083434 H083509 H083582 H083670 H191059

H083035 H083105 H083170 H083237 H083303 H083370 H083436 H083510 H083583 H083671 H191060

H083036 H083106 H083171 H083238 H083304 H083371 H083437 H083511 H083584 H083674 H191061

H083037 H083107 H083172 H083239 H083306 H083372 H083438 H083512 H083585 H083682 H191063

H083038 H083108 H083173 H083241 H083308 H083373 H083439 H083513 H083586 H083687 H191064

H083039 H083109 H083174 H083242 H083309 H083374 H083440 H083514 H083587 H083689 H191066

H083040 H083110 H083175 H083243 H083310 H083375 H083441 H083515 H083588 H083690 H191067


20/20



V i PN CP 0 00 R C 20 f 20

APPENDIX DLIST OF SERIAL NUMBERS

H080025 H081131 H083752 H083824 H084012

H080070 H081141 H083754 H083825 H084013

H080098 H081148 H083755 H083827 H084016

H080897 H081149 H083757 H083830 H084017

H080936 H081150 H083758 H083831 H084019

H080939 H081153 H083761 H083832 H084021

H080944 H081164 H083763 H083833 H084022

H080947 H081165 H083764 H083835 H084023

H080960 H081169 H083765 H083836 H084024

H080962 H081183 H083766 H083837 H084025

H080969 H082250 H083767 H083839 H084026

H080970 H083444 H083768 H083885 H084028

H080989 H083474 H083769 H083941 H084030

H080991 H083479 H083770 H083943 H084031

H080997 H083483 H083771 H083944 H084032

H081004 H083531 H083772 H083946 H084033

H081005 H083535 H083773 H083947 H084037

H081006 H083547 H083774 H083949 H084039

H081007 H083614 H083775 H083950 H084040

H081009 H083619 H083777 H083951 H084041

H081017 H083627 H083778 H083952 H084042

H081019 H083633 H083779 H083953 H084043

H081020 H083640 H083780 H083954 H084047

H081023 H083644 H083781 H083955 H084051

H081025 H083661 H083782 H083957 H084054

H081026 H083672 H083783 H083958 H084055

H081027 H083676 H083786 H083963 H084057

H081031 H083678 H083787 H083964 H084062

H081034 H083686 H083788 H083967 H084063

H081035 H083693 H083789 H083968 H084064

H081037 H083695 H083790 H083969 H084065

H081038 H083696 H083791 H083970 H084070

H081042 H083700 H083792 H083971 H084077

H081043 H083703 H083793 H083973 H084078

H081044 H083705 H083794 H083974 H084079

H081045 H083706 H083796 H083978 H084080

H081046 H083707 H083798 H083979 H084088

H081050 H083709 H083799 H083980 H084095

H081051 H083710 H083800 H083981 H084096

H081058 H083712 H083803 H083983 H084097

H081067 H083716 H083804 H083985 H084105

H081080 H083721 H083805 H083986 H084111

H081081 H083722 H083806 H083988 H084115

H081082 H083724 H083807 H083990 H084116

H081088 H083725 H083808 H083991 H084119

H081095 H083726 H083809 H083993 H084121

H081100 H083727 H083810 H083994 H084122

H081105 H083729 H083811 H083996 H084128

H081107

H083732

H083812

H083997

H084146

H081108 H083734 H083813 H083998 H084148

H081109 H083737 H083814 H083999 H088675

H081110 H083738 H083815 H084000 H089575

H081112 H083739 H083816 H084002

H081118 H083740 H083817 H084003

H081119 H083741 H083818 H084004

H081120 H083742 H083819 H084007

H081122 H083743 H083821 H084008

H081125 H083748 H083822 H084010

improper scaling of reference ct images in the 3d match environment

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