improving the world with genomics - university of alberta · metabolomics, metagenomics,...
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Ryan Mercer, PhDResearch Manager – Genome Alberta
U of A Research Funding FairNovember 22nd, 2018
Improving the World with Genomics
• Brief Background• Past & Present Funding
Opportunities• Genome Alberta Support• Success Stories & Building
Partnerships
Overview
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Canada’s Genomics Enterprise
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Genome Alberta is a publicly funded not-for-profit corporation
which initiates, funds, and manages genomics research and
partnerships.
Core Activities and Services
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A Brief history
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2000• Genome Canada & 5 Regional Genome Centres (Genome BC, Genome Prairie,
Ontario Genomics Institute, Genome Québec, Genome Atlantic) established
2003• Government of Alberta advances Life Sciences Strategy (genomics is an integral
component)
2005• Genome Alberta (6th Regional Genome Centre) established after consultation
with Genome Canada, Industry Canada and the Province of Alberta
2015• Genome Alberta initiates, funds and manages $155.6M in genomics research and
partnerships in its first 10 years of operation
2017• Genome Alberta portfolio approaches $250M in genomics projects and
partnerships
Genomics
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The term genomics is defined here as the comprehensive study, using high throughput technologies, of the genetic information of a
cell or organism and its functions .
This includes related disciplines such as proteomics, metabolomics, metagenomics, pharmacogenomics, and
bioinformatics.
Funding the Value Spectrum
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GE3LS Research
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Genomics and it’s Ethical, Environmental, Economic, Legal and Societal Aspects
• Integrates the social science and humanities research fields to inform the appropriate development and ensure the uptake of genomics research in society
• Addressed the barriers to implementation of genomics research
• Required GE3LS research components integrated into ALL LSARP projects
• Genome Canada also funds stand-alone GE3LS projects through the LSARP competitions
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2018 Large-Scale Applied Research Project Competition (LSARP):
Genomics Solutions for Agriculture, Agri-food, Fisheries and Aquaculture
Launched June, 2018
2018 LSARP
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Aims to support projects that will demonstrate how genomics research can be translated into solutions that advance the sustainability, productive capacity and the resulting competitive position of the Canadian agriculture/agri-food and fisheries/aquaculture sector.
Launch: June 2018Scope: GC will invest $1 - $4 million in an individual projectFunding Available: $30 million from Genome Canada, $16 million to support AAFC researchersCo-funding: 1:1 co-funding requirement from eligible sources
Additional details on Genome Canada’s website
2018 LSARP – Timelines
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F2F Interview
Interview with review panel
Funding Decision
Date Process
June 2018 Launch of competition
August 16, 2018 Deadline for submitting registrations to Genome Canada
November 15, 2018 Deadline for submitting pre-applications to Genome CanadaLate January 2019 Applicants notified of results of pre-application
April 11, 2019 Deadline for full applications to Genome Canada
Late May, 2019 Review committee meets (including meetings with applicants)
Late June 2019 Decisions by Genome Canada and AAFC
Late June 2019 Notification of Decision
We are here
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Eligible sources:- In-kind contributions- Industry cash- VC or investment funds- Federal, provincial, and
municipal governments- Institutional funds- International
collaboratorsIneligible sources:- Tri-council Funding - Tri-council Programs
50%
15%
20%
10%5%
TOTAL BUDGETGenome Canada International Partners
Alberta Innovates Industry Cash
Industry In-Kind
Example project budget and co-funding:
Competition – Support
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1. Coordination and Facilitationa) Mini-workshopsb) Strategic Planningc) Stakeholder Meetingsd) Support personnel and consultantse) External expert review f) Mock-panel
2. Financiala) Travel/Accommodation for Team
Membersb) Writing/Coordination Support
Past, Present & Future
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Genomic Applications Partnership Program (GAPP)
Ongoing Competition
Bridging the Gap…
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• Scope: funds projects from $300,000 up to $6 million in total size• Co-funding: Genome Canada will provide 1/3, End-user(s) must provide at
least 1/3, remaining 1/3 must come from eligible sources.• Term: minimum term of 6 months, maximum term of 3 years
GAPP
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User:
• Companies, industry consortia, government departments or agencies, or not-for-profits that have a credible plan for exploiting project results for the socio-economic benefit of Canada
Academic:
• An independent investigator who is a faculty member employed by a Canadian post-secondary organization or affiliated institutions (hospitals and research institutes)
• Researchers from not-for-profit organizations with explicit research mandate (including Provincial labs)
1. Respond to the objectives2. Active partnership between Academic and User3. Propose to utilize or develop a genomics derived solution4. Address key challenges or opportunities defined by the user (User “pull”)5. Focus on downstream R&D activities with measurable impact
Applications are accepted on a rolling intake and are reviewed quarterly
GAPP – Eligibility
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A real world challenge: • Bloodstream infections cause
8,000 deaths per year in Canada• Microbiology testing delays
directly contribute to deaths around the world
• Currently takes 2-5 days for tests
Device for the rapid detection of six common bloodstream infections and assessment of antibiotic susceptibility
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A microscale metabolomics solution: • Microscale testing takes <6 hours, increasing
survival rates 5x higher• Project aims to refine, enhance, and validate
the microscale metabolomics prototype device
Ian Lewis, University of Calgary & Deirdre Church, Calgary Laboratory Services
$6 Million total project budget
Commercial opportunity: • Sub-optimal genetic improvement rate at
nucleus level• Sub-optimal expression of nucleus
improvement at commercial level
Development of Genomic Crossbred Estimated Breeding Values to maximize profitability for Canadian pork producers
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Project goal:• Develop and validate a superior
genomic selection tool to increase the rate and transfer of genetic improvement to the commercial pork producer
Graham Plastow, University of Alberta & Bob Kemp, Genesus Inc.
Approx. $3.4 Million project budget
Retailers & Food ServicePackers & Processors
Commercial Pork Producers
Multiplication
Nucleus
Consumers
Genetics Industry
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Partnership Development
• Applied Livestock Genomics Program (ALGP) I/II
• Rapid Response to PEDv• LSARP 2014
• Listeria monocytogenes – Emerging issue• Alberta Precision Health Initiative (APHI)• LSARP 2017
• Alberta Applied Agricultural Genomics Program (A3GP)
• LSARP 2018
Technology Platforms
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The MetabolomicsInnovation Centre
Comprehensive, Quantitative Metabolomics Services
www.metabolomicscentre.ca
Services and Assays
Full descriptions, metabolite panels and prices available at www.metabolomicscentre.ca
Business, Collaborations and Project InquiriesJennifer Reid, Business Development [email protected]
Scientific and Technical InquiriesDr. David Wishart, [email protected]. Rupa Mandal, Facilities [email protected]
Contact InformationContact Information
www.metabolomicscentre.ca
Q&A and Discussion
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Ryan Mercer,Research [email protected]
Niall Kerrigan, Program [email protected]
Anita Ludwar,Business Development [email protected]
For more information and to stay up to date, please visit our website: http://genomealberta.ca/funding/