in-silico and in-vitro analysis of exon 18 of aspm gene and its importance in determining mammalian...

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  • 7/31/2019 In-silico and In-vitro Analysis of Exon 18 of ASPM Gene and Its Importance in Determining Mammalian Brain Size.

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    Kd.sk`kce bdi Kd.vky}e Bdb`{sks ef G|ed 2< ef BS_N Jgdg bdi Kys

    Knpe}ybdcg kd Igyg}nkdkdj Nbnnb`kbd M}bkd Skxg$

    B p}ehgcy }gpe}y swmnkyygi kd pb}ykb` fw`fk``ngdy

    ef ylg }grwk}gngdy ef ylg bzb}i ef ylg igj}gg ef

    Hbzblb}`b` Dgl}w Ygclde`ejkcb` Wdkvg}sky{L{ig}bmbi

    MBCLG@E] EF YGCLDE@EJ[

    kd

    MKEYGCLDE@EJ[

    M{

    Dbng ]gji$De$

    BLNGI NEKDWIIKD FBKSB@ ?

  • 7/31/2019 In-silico and In-vitro Analysis of Exon 18 of ASPM Gene and Its Importance in Determining Mammalian Brain Size.

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    =

    CG]YKFKCBYKED

    Ylks ks ye cg}ykf{ ylby ylg _}ehgcy ze}a }gpe}ygi kd ylg ylgsks gdyky`gi Kd.sk`kce bdi

    Kd.vky}e Bdb`{sks ef G|ed 2< ef BS_N Jgdg bdi Kys Knpe}ybdcg kd Igyg}nkdkdj

    Nbnnb`kbd M}bkd Skxg$ swmnkyygi kd pb}ykb` fw`fk``ngdy ef ylg }grwk}gngdy fe} bzb}i ef

    ylg igj}gg Mbclg`e} ef Ygclde`ej{ kd Mkeygclde`ej{ f}en Hbzblb}`b` Dgl}w

    Ygclde`ejkcb` Wdkvg}sky{ L{ig}bmbi cb}}kgi ewy m{ BLNGI NEKDWIIKD

    FBKSB@ ,?

  • 7/31/2019 In-silico and In-vitro Analysis of Exon 18 of ASPM Gene and Its Importance in Determining Mammalian Brain Size.

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  • 7/31/2019 In-silico and In-vitro Analysis of Exon 18 of ASPM Gene and Its Importance in Determining Mammalian Brain Size.

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    9

    BCADEZ@GIJGNGDY

    K ezg n{ skdcg}g ylbdas ye MB@BHK S$]BE Ik}gcye} ef Dyl}{s Mkeygcl @bms

    L{ig}bmbi fe} lks vb`wbm`g jwkibdcg bssksybdcg bivkcg bdi gdcew}bjgngdy yl}ewjlewy

    ylg gdyk}g p}ecgss ef ylks p}ehgcy ze}a bdi fe} p}evkikdj ng zkyl swcl b syknw`bykdj

    gdvk}edngdy kd zlkcl ye cediwcy ylks }gsgb}cl$

    Ky ks zkyl j}bykywig ylby K }gce}i lg}g ylg vg}{ akdi bdi kdvb`wbm`g jwkibdcg

    swjjgsykeds bdi bcbignkc swppe}y ef N}s$Y$]elkdk ]gii{ Lgbi ef ylg Igpb}yngdy

    CN] Ce``gjg ef Gdjkdgg}kdj bdi Ygclde`ej{ yl}ewjlewy ylg cew}sg pg}kei$

    K zew`i `kag ye ylbdaI}$M$ Vkhb{b`baslnk n{ p}ehgcy swpg}vkse} fe} g|ygdikdj

    lg} swppe}y kd cenp`gykdj n{ p}ehgcy ze}a$

    K bn kdigmygi ye n{ ygbclkdj sybff N}$_$S}kdkvbsb Clb}{ N}$ _$Mbmhk bdi

    N}$ Ak}bd Awnb} fe} ylgk} vb`wbm`g swjjgsykeds bivkcg bdi gdcew}bjgngdy yl}ewjlewy

    ylg gdyk}g p}ecgss$

    K zew`i b`se `kag ye ylbda ew} @bm Ygcldkckbds N}$ D$ S}kdkvbs bdi N}$A$

    ]bhgdi}b _}bsbi CN] Ce``gjg ef Gdjkdgg}kdj bdi Ygclde`ej{ fe} ylgk} vb`wbm`g

    swppe}y bdi jwkibdcg$

    Kbn lkjl`{ kdigmygi ye I}$ N$ ]bnb`kdjb ]gii{ _}kdckpb` CN] Ce``gjg ef

    Gdjkdgg}kdj bdi Ygclde`ej{ fe} jkvkdj ng pg}nkssked ye cb}}{ ewy ylks p}ehgcy$

  • 7/31/2019 In-silico and In-vitro Analysis of Exon 18 of ASPM Gene and Its Importance in Determining Mammalian Brain Size.

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    7

    CEDYGDYS

    2$

    Kdy}eiwcyked2$2 Zlby ks BS_N jgdg5