Judith Trotman (Concord)

Roslyn Ristuccia (St George)

Haematology Clinical Research Network NSW

Increasing Cross-Referral and Recruitment to Clinical Trials: A New APProach

Our problem in 2013: significant challenges recruiting patients to haematology trials

• Broad spectrum of diseases

• Geographical challenges

• Barrier - knowledge management for ~90 trials. What & where?

• Assumption - haematologists won’t refer patients to other hospitals

• Assumption - patients will not travel

Aims:

• To develop a free App to facilitate patient cross-referral to NSW Haematology Trials

• to measure App uptake & effectiveness:

– rates of cross-referral

– clinical trial recruitment

– overall haematology trial unit staffing

– analysing app usage

ClinTrial Refer App Development A mobile app: free, simple, effective.

• ClinTrial Refer developed with App developer:

• Go-live on Google Play & iTunes June 2013

• Searchable by: Disease, Location, Trial Status and Sponsor.

• Real-time data entry into a streamlined back-end database ensures currency of information.

• Co-operation between trial unit managers ensures comprehensive trial data.

• Select disease

• Click “Search” to see currently recruiting trials

• View: - Trial Details - Trial Summary - ANZCTR link - Inclusion Criteria - Exclusion Criteria - Identify hospitals - Contacts

• Push Notifications: new trials

ClinTrial Refer

Results: Haematology NSW Jan 2012–Dec 2016

1° endpoint: instant & sustained 9x increase in cross-referral

64% increase in

patient recruitment

60% increase in

Trial Staff FTE

2° endpoints:

The NSW Impact

Haematology Cross-Referral activity Jan 2016 – May 2017

ClinTrial Refer is a template:

Results: ClinTrial Refer Australia & New Zealand

• Unique National Database for current recruiting Haematology Clinical Trials

ClinTrial Refer Melanoma 127% increase in recruitment at MIA. >40 different Australian and international sites.

ClinTrial Refer Melanoma Driven by a rural oncologist…

Beyond cancer: future licensees

Results: 2° endpoint - app usage metrics

An award winning application recognised by the following: • 2017 HeroX Clinical Trials Innovation Prize, WINNER of $50,000 USD • 2017 International Conference Malignant Lymphoma, Poster • 2016 American Society of Clinical Oncology, ClinTrial Refer Melanoma Poster • 2016 Australian Clinical Trials Alliance meeting, Best Moderated Poster • 2015 57th American Society Haematology Annual Meeting, ORAL Abstract • 2015 Premier's Awards for Public Service, FINALIST • 2015 St George & Sutherland Research Symposium Abstract • 2015 Sydney Catalyst, Winner Boast and Toast • 2014 PREMIER’S AWARD for Outstanding Cancer Research: Innovation in Clinical Trials • 2014 Haematology Society of Australia & New Zealand, Abstract • 2013 NSW Health Innovation, Building Partnerships Awards, FINALIST • 2013 NSW Health Innovation, Director General’s Award for Integrated Care, FINALIST • 2013 NSW Health Innovation Awards, Poster • 2013 CINSW Innovation in Cancer Services and Care Conference, BEST ABSTRACT • 2013 American Society of Hematology Annual Meeting and Exposition, Abstract.

Awards and Abstracts

www.clintrial.org.au

Purpose

Provide a platform for users and also act as a resource hub for subscribing members

www.clintrial.org.au

WEBSITE

It’s not just about the App…

• It’s about the culture change, the collaboration it generates.

• ClinTrial Refer has been the tool to facilitate this, and has the potential to do so much more ....

Our Future: • ClinTrial Refer Australia

• ClinTrial Recruit Australia

• Strategic difference in the way data is collected and delivered • Saignificantly enhanced clinical trial cross-referral, recruitment

nd trial unit activity in NSW • Increased patient access and Australian researcher’s contribution

to clinical trials,

• Adopted successfully across numerous other geographical areas & disciplines

Conclusion