index [jpet.aspetjournals.org] · 2006. 1. 27. · sal,neuroblastoma cells,368 cyclicamp...
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INDEX
Volume 264, January-March, 1993
A-75200, actions on norepinephrine uptakeand release, bovine adrenal chromaf-fin cells, 1206
Aagaard, P. J., see Mckinney, M, 74Aalkjaer, C., see Juul, B., 1234Abdel-Rahman, A. A., see El-Mas, M. M.,
1198Abecarnil, long-term treatment, no induc-
tion of diazepam-like dependence(mice), 1395
Abels, B. C., Branch, R. A. and Sabra, R.:Interaction between thromboxane A2and angiotensin II in postischemicrenal vasoconstriction in dogs, 1285
Ableitner, A., see Bals-Kubik, R., 489Acetohexamide reductase, hormonal regu-
lation, postnatal development andsex-related differences, liver and kid-ney (rats), 166
Acetylcholineneurally mediated action of leukotrienes,
ion transport, distal colon (guineapigs), 384
presynaptic cholinergic actions, DuP 996
(rats), 910striated dopaniine and, quinpirole, com-
parisons with B-HT 920 and SND919, 1344
tachykinins and, ascending enteric reflex
contraction, propagation of excita-tion (guinea pigs), 391
Acetylcholinesterasegastroprokinetic activity of nizatidine
(dogs, rats), 152
pyridostigmine and HI-6, comparison ofantidote protection, soman, 1085
Acidosis, glycolysis and glucose oxidation,fatty acids, aerobic reperfusion of is-chemic hearts (rats), 135
Acquired immunodeficiency syndrome, dis-tributional transport kinetics of zi-dovudine, plasma, brain extracellular
fluid/cerebrospinal fluid (rabbits),
899AD-5423, pharmacological profile (mice,
rats), 158
Adachi, T., see Fujita, S., 226Adenosine
endogenous, manipulation in prepiriformcortex, seizure susceptibility (rats),
1415
-stimulated contraction, lack of cyclo-ox-ygenase involvement, nonpregnant
myometrium (guinea pigs), 1033Adenosine triphosphate
contractile effects of nucleotides, trachea(guinea pigs), 210
modulation of low affinity binding sites,nucleotides and glibenclamide, brain(rata), 701
related nucleotides and, tone, mesenteric
resistance arteries (rats), 1234Adenylate cyclase
ethanol-induced desensitization, adeno-
1492
sine receptor, GTP-binding proteins,
977
methoxy-chroman derivatives, agonist
properties, central 5-HT1A receptors(rats), 863
Adenylyl cyclaseantisense oligodeoxynucleotide to mes-
senger RNAs, seven transmembrane
spanning regions, cerebellar granulecells (rats), 423
chronic etorphine-induced sensitization,buprenorphine prevention and rever-sal, neuroblastoma cells, 368
cyclic AMP accumulation, bicarbonate-induced sensitization, astrocytomacells (humans), 1211
Adler, M. W., see Bussiere, J. L., 591Adrenal chromaffin cells
actions of A-7500, norepinephrine uptakeand release (cattle), 1206
cholinergic agonist- and K�-induced cy-tosolic-free Ca’’ signals, effects ofcaffeine (pigs), 770
Adrenalectomy, kinetics of drug action in
disease states, phenobarbital andtheophylline, pain sensitivity (rats),859
Adrenal medulla, modulation of inhibition,bradykinin-induced plasma extrava-sation, intrathecal nicotine (rats),
839
Adrenoceptorsalpha, morphine-induced suppression,
splenocyte natural killer activity,1179
alpha-iacute and chronic hypertensive mech-
anism, ketanserin (rats), 129control of cataplexy, narcolepsy (dogs),
1079
alpha-2characterization of subtypes, brain (hu-
mans), 967
dexmedetomidine, ST-91 and cloni-dine, 327
discrimination and pharmacologicalcharacterization, I2-imidazoline sites(humans, rats),1187
inner medullary collecting duct cells,kidney (rabbits), 879
mu opioid, enteric nerves (guinea pigs),375
rauwolscine, contraction in mesentericartery (dogs), 201
beta-i and beta-2, coupling to cyclic AMPsystem, connecting tubules of neph-
ron (rabbits), 105
AF64A, lesions of striatum, ipsilateral no-tations, D2 dopamine agonists (mice),824
AF-DX 116, autoradiographic mapping, M3
muscarinic receptors, brain (rats),415
Agingr-aminobutyric acid-induced depression,
ethanol effects, cerebellar Purkinje
neurons(rats),951decreased sensitivity to cAMP, genera-
tion, memory splenic cytotoxic T-lymphocytes, 1381
Airway, bradykinin effects in tracheal epi-thelial cells, mediation through B2
kinin receptor, inhibition by Hoe 140(guinea pigs), 1124
Aita, H., see Ueki, S., 152Alaoui-Jamali, M. A., Schecter, R. L., Rus-
turn, Y. M., Centurioni, M. G., Leh-
nert, S. and Batist, G.: In vivo rever-sal of doxorubicin resistance by a new
tiapamil analog Roll-2933, 1299
Alcohol, exposure, two-step mechanism, cy-tochrome P450 CYP 2E1 induction
(rats), 944Aldosterone, hormonal and cardiovascular
effects, losartan (monkeys), 6Alfentanil
-induced antinociception, fl-funaltrexam-me and naloxonazine, muscle rigidity(rats),739
respiratory depressant effects, apparentpA2 analysis (monkeys), 145
Alkylating agents, multiple muscarinic re-ceptor subtypes, activation of phos-pholipase C, brain cortical mem-branes (rats), 521
Alzheimer’s disease, pharmacological char-acterization, hippocampal musca-rinic autoreceptor (rats), 74
Amenta, F., see Ricci, A., 431
Amico, M. C., see Valeri, P., 1028Amidines, bis(5-amidino-2-benzimidazo-
lyl)methane, reversible inhibitors,mast cell tryptases (dogs), 676
Amiloridebis(5-amidino-2-benzimidazo-
lyl)methane, reversible inhibitors,mast cell tryptases (dogs), 676
contractile effects of nucleotides, trachea(guineapigs),210
relaxant effects of nucleotides, trachea
(guinea pigs), 217synthesis of dopamine in kidney, role of
sodium (rats), 4062-Amino-4,5-(i,2-cyclohexyl)-7-phospho-
noheptanoic acid, discriminative
stimulus, pharmacological specificity(rats), 845
Amino acidsendogenous excitatory, outflow of dopa-
mine, nucleus accumbens (rats), 289excitatory, agonists, dipsogenic effects
(pigeons),918
Aminoalkylindole, binding in cerebellum
(rats), 1352-y-Aminobutyric acid, modulation of �S-
TBPS binding, bicuculline-producedregional differences, cerebellum andcortex (mice), 638
r-Aminobutyric acid, -induced depressions,
1993 Index 1493
ethanol effects, cerebellar Purkinjeneurons (rats), 951
Aminohydroxybutane bisphosphonate,clenbuterol and, prevention of bonechanges, retardation of muscle atro-phy (rats), 1071
Aminophylline, isozyme-selective phospho-diesterase inhibitors, pulmonary an-tiallergic and bronchodilator effects(guinea pigs), 609
4-Aminopyridine, block of transient out-ward K� current, ventricular myo-cytes (rats), 1450
5-Aminosalicylic acid, epidermal growthfactor, experimental colitis (rats),
984Amoroso, S., Sensi, S., Di Renzo, G. and
Annunziato, L.: Inhibition of theNa�-Ca� exchanger enhances an-
oxia and glucopenia-induced [3H] as-partate release in hippocampal slices,515
Amphetaminerole of forebrain, responsiveness of nigro-
striated dopamine neurons, dopamineagonists (rats), 616
sensitization, autoreceptor subsensitivity,enhanced dopamine release (rats),249
d-Amphetamine, triazolam discrimination,
selectivity and sensitivity, novel-re-sponse procedure (humans), 360
Amphotericin B, synthesis of dopamine in
kidney, role of sodium (rats), 406Analgesia, thermal antinociception, cloni-
dine, dexmedetomidine and xylazine(monkeys), 762
Anesthetics, trichloroethanol-potentiated
synaptic transmission, mediation byGABAA receptors, hippocampal neu-
rons, 1097Angiogenesis, inhibitor TNP-470, antitu-
mor effects, VX-2 carcinoma (rab-bits), 469
Angiotensin converting enzyme, neurogenicplasma extravasation, nasal mucosa,peptidase inhibitors (rats), 509
Angiotensin IIdistinct signal transduction pathways,
gastric smooth muscle (guinea pigs),958
hormonal and cardiovascular effects, lo-sartan (monkeys), 6
inhibitory effects of DuP 753 and EXP3174, hindquarters vascular bed(cats), 1104
renal microvascular actions of YM435(rats), 1154
thromboxane A2 and, postischemic renalvasoconstriction (dogs), 1285
Annunziato, L., see Amoroso, S., 515Anoxia, inhibition of Na�-Ca� exchanger,
glucopenia-induced aspartate release,
hippocampal slices (rats), 515Antibiotics, macrolide, potent inhibitory ef-
feet, mono-N-dealkylation metabo-lism of disopyramide (humans), 1425
Antibodies, D3 dopamine receptor, pharma-cologic properties, development ofantibodies (rats), 1002
Antibody response, gallium arsenide-in-duced suppression, reversal, mixeddisulfide metabolite of meso-2,3-di-mercaptosuccinic acid (mice), 695
Anticonvulsant agents, felbamate, neuro-
protectant action, strychnine-insen-
sitive glycine receptors, 1248
Antidepressant, -like effects of rolipram, be-havior, differential reinforcement oflow response rate (rats), 1168
Antimuscarinic agents, differential effects,intestinal motility (dogs), 789
Antinatriuresis, renal nerve stimulation-in-duced, suppression by TMB-8 (dogs),117
Antinociceptionalfentanil-induced, �3-funaltrexamine and
naloxonazine, muscle rigidity (rats),739
chronic spinal infusion, dexmedetomi-dine, ST-91 and clonidine, 327
thermal, clonidine, dexmedetomidine andxylazine (monkeys), 762
Antisense oligodeoxynucleotide, messenger
RNAs encoding receptors, seventransmembrane spanning regions,cerebellar granule cells (rats), 423
Antrum, motility, cisapride and 5-hydroxy-
tryptamine (dogs), 79Anxiety
benzodiazepine withdrawal, conflicting
evidence regarding efficacy, ondan-setron(rats), 622
long-term treatment with abecarnil, noinduction of diazepam-like depend-ence (mice), 1395
Ao, S., see Sogabe, K., 1040Aorta
baroreceptors, ethanol-induced impair-
ment, baroreflex control (rats), 1198metabolic activation of glyceryl trinitrate,
lack of involvement of cytochrome P-450 (rabbits), 1432
Apomorphine, impairment of latent learn-ing (mice), 122
Apoproteinchronic alcohol exposure, two-step mech-
anism, cytochrome P450 CYP 2E1induction (rats), 944
chronic intragastric ethanol infusion, ep-isodic ethanol excretion (rats), 938
Apseloff, G., Girten, B., Walker, M., She-
pard, D. R., Krecic, M. E., Stern, L.
S. and Gerber, N.: Aminohydroxy-
butane bisphosphonate and clenbu-terol prevent bone changes and re-tard muscle atrophy, respectively in
tail-suspended rats, 1071Arachidonic acid
release, Bi and B2 kinin receptors, supe-
nor mesenteric artery smooth musclecells (rabbits), 930
twitch tension, phrenic nerve-diaphragm(rats),1311
Archer, S., see Jiang, Q., 1021Arentzen, C., see Jia, H., 1275Arneklo-Nobin, B., see Bodelsson, M., 709Arneson-Rotert, L. J., see Toews, M. L.,
1211Arrigoni, J., see Nishino, S., 1079Arsenic, gallium arsenide-induced suppres-
sion of antibody response, reversal,
mixed disulfide metabolite of meso-2,3-dimercaptosuccinic acid (mice),695
Arterycoronary
cocaine sensitization, drug-inducedspasm (cattle), 1132
pharmacological analysis of vasodila-
tion, extracellular adenosine 3 ‘ ,5 ‘ -
cyclic monophosphate (dogs), 1253serotonin-induced contraction, ergo-
lines (pigs), 193thrombolysis, heparin/aspirin/Ro 43-
5054 (dogs), 501vasomotor responses, NG�monomethyl�
L-arginine and Nw nitro-L-argininemethyl ester, 265
mesenteric, induction of contraction by
rauwolscine, precontraction with
KC1 and endothelin-1 (dogs), 201mesenteric resistance, tone of, effects of
ATP and related nucleotides (rats),1234
neurokinin A derivatives, agonist and an-tagonist properties, C-terminal ami-
dation (guinea pigs, rabbits, hamster,rats), 17
superior mesenteric, Bi and B2 kinin ne-ceptors, smooth muscle cells (nab-
bits), 930tail, acute effects of nicotine, mesenteric
vasculature (rats), 1305
Arthritis
adrenal medullary modulation, bradyki-
nm-induced plasma extravasation,intrathecal nicotine (rats), 839
repression of drug-metabolizing enzymes,interleukin lfl (rats), 1012
Asano, Y., see Homma, S., 105Asante, N. K., see Winn, M. J., 265
Aspartatedistinct actions of endogenous excitatory
amino acids, outflow of dopamine,nucleus accumbens (rats), 289
glucopenia-induced release, inhibition ofNa�-Ca� exchanger, hippocampal
slices (rats), 515Aspirin, coronary artery reperfusion and
reocclusion, thrombolysis, tissue-type plasminogen activator (dogs),501
Asthma, pulmonary antiallergic and bron-chodilator effects, isozyme-selectivephosphodiesterase inhibitors (guineapigs), 609
Astrocytoma, bicarbonate-induced sensiti-zation, cyclic AMP accumulation(humans), 1211
Ataxia, behavior and pharmacokinetic
study, phenylcyclohexylethylamineand its metabolite (rats), 1401
Atrial cells, single, lidocaine block, sodiumchannels (humans), 1275
Atrial natriuretic factor, alteration of neu-rotransmission, guanylate cyclase-coupled receptors, vas deferens (nab-
bits), 1227
Atnopine, comparison of antidote protectionagainst soman, pyridostigmine, HI-6and acetylcholinesterase, 1085
Autonomic nervous system, ileum, nitric ox-ide synthase (dogs), 234
Autoradiographylocalization of dopamine D1 receptors,
kidney (humans), 431mapping of M3 muscarinic receptors,
brain (rats), 415
quinpirole binding, dopamine D2 and D3receptors, brain and pituitary gland(rats), 991
Autoreceptorshippocampal muscaninic, pharmacologi-
cal characterization (rats), 74
1494 Index Vol. 264
subsensitivity, enhanced dopamine re-lease, amphetamine sensitization(rats), 249
Bacci, E., see Caughey, G. H., 676Bacci, E., see Petersson, G., 509Backer, C., see Jia, H., 1275Baculovirus, D3 dopamine receptor, phar-
macologic properties, development ofantibodies (rats), 1002
Badger, T. M., Crouch, J., Irby, D. andShahare, M.: Episodic excretion ofethanol during chronic intragastricethanol infusion in the male rat: Con-
tinuous vs. cyclic ethanol and nu-trient infusions, 938
Badger, T. M., Ronis, M. J. J., Lumpkin, C.K., Shahare, M., Irby, D., Huang, J.,Mercado, C., Thomas, P., Ingelman-Sundberg, M. and Crouch, J.: Effectsof chronic ethanol on growth hor-mone secretion and hepatic cyto-chrome P450 isozymes of the rat, 438
Badger, T. M., see Ronis, M. J. J., 944Badillo, J. M., see Thomas G. R., 67Balasubramaniam, G., Lee, H. S. and Mah,
S. C.: Differences in the acute andchronic antihypertensive mechanism
of action of ketanserin spontaneouslyhypertensive rats, 129
Bals-Kubik, R., Ableitner, A., Herz, A. andShippenberg, T. S.: Neuroanatomicalsites mediating the motivational ef-fects of opioids as mapped by the
conditioned place preference para-digm in rats, 489
Baister, R. L., see Bobelis, D. J., 845Balster, R. L., see Evans, E. B., 726Barium chloride, interaction of sodium and
potassium channel blockers, papil-lary muscle (guinea pigs), 1056
Barnette, M. S., Manning, C. D., Price, W.J. and Barone, F. C.: Initial biochem-ical and functional characterizationof cyclic nucleotide phosphodiester-
ase isozymes in canine colonicsmooth muscle, 801
Baron, S. P. and Woods, J. H.: Dipsogeniceffects of excitatory amino acid ago-nists in pigeons, 918
Barone, F. C., see Barnette, M. S., 801Baroreceptors, aortic, ethanol-induced im-
pairment, baroreflex control of heartrate (rats), 1198
Baroreflex
acute and chronic hypertensive mecha-
nism, ketanserin (rats), 129control of heart rate, ethanol-induced im-
pairment, aortic baroreceptors (rats),1198
Barr, R. L., see Lopaschuk, G. D, 135Barturen, F., see Miralles, A., 1187Basbaum, A. I., see Miao, F. J.-P., 839
Bass, P., see Luck, M. S., 984Bathon, J. M., see Proud, D., 1124Batist, G., see Alaoui-Jamali, M. A., 1299Batt, A.-M., see Ferrari, L., 1012Bealer, S. L.: Histamine releases norepi-
nephrine in the paraventricular nu-cleus/anterior hypothalamus of theconscious rat, 734
Bednar, D. L., see Ferkany, J. W., 256Behavior
autoreceptor subsensitivity, enhanced do-pamine release, amphetamine sensi-tization (rats), 249
differential reinforcement of low responserate, antidepressant-like effects of ro-lipram (rats), 1168
dipsogenic effects, excitatory amino acidagonists (pigeons), 918
effects of 1-phenylbiguanide and m-chlo-rophenylbiguanide (rats), 1440
ipsilateral rotations, AF64A lesions ofstriatum, D2 dopamine agonists
(mice), 824learning and performance, acute effects,
triazolam and lorazepam (humans),1218
pharmacokinetic study and, phenylcy-clohexylethylamine and its metabo-lite(rats), 1401
triazolam discrimination, selectivity andsensitivity, novel-response procedure
(humans), 360Bell, W. E., see Bender, B. S., 1381
Bellan, J. A., see Osei, S. Y., 1104Belt, J. J., see Fedan, J. S., 210, 217Ben-An, Y., see Zini, S., 701
Bender, B. S., Bell, W. B., Taylor, S. andScarpace, P. J.: Decreased sensitivityto cAMP in the In vitro generation
of memory splenic cytotoxic T-lym-phocytes from aged mice: Role ofphosphodiesterase, 1381
Bengtsson, H. -I., see Lundin, S., 783
Bennett, W. F., see Thomas G. R., 67
Benowitz, N. L., see Miao, F. J.-P., 839
Benzodiazepinesacute effects of triazolam and lorazepam,
learning, performance and subjectratings (humans), 1218
chlordiazepoxide, block of two types ofcalcium channels, neuroblastomacells (mice), 22
long-term treatment with abecarnil, noinduction of diazepam-like depend-ence (mice), 1395
withdrawal, conflicting evidence regard-
ing efficacy, ondansetron (rats), 622
6,7-Benzomorphans, properties of epsilonopioid receptor, brain (rats, guineapigs, cows, pigs, chickens), 349
Bergsbaken, C. L., Sommers, S. L. and Law,P. Y.: Effect of forskolin and isobu-tylmethylxanthine on Delta-opioid
receptor activity in neuroblastoma x
glioma NG1O8-15 cells, 1474
Bertz, R. J., see Kroboth, P. D., 1047Bervoets, K., Rivet, J.-M. and Millan, M.
J.: 5-HT1A receptors and the tail flickresponse. IV. Spinally localalized 5-HT1A receptors postsynaptic to sero-toninergic neurones mediate sponta-neous tail-flicks in the rat, 95
Beta blockers, coupling of beta-i and beta-2adrenoceptors, cyclic AMP system,connecting tubules of nephron (rab-bits), 105
B-HT 920, comparisons with quinpirole andSND 919, striatal dopamine and ace-tylcholine release, 1344
Bicarbonate, induction of sensitization,cyclic AMP accumulation, astrocy-toma cells (humans), 1211
Bickel, W. K., Oliveto, A. H., Kamien, J. B.,Higgins, S. T. and Hughes, J. R.: Anovel-response procedure enhancesthe selectivity and sensitivity of atniazolam discrimination in humans,360
Bickel, W. K., see Rush, C. R., 1218Bickford, P. C., see Lin, A. M.-Y., 951Bicuculline, -produced regional differences,
modulation of nS�ThPS binding byvarious agents, cerebellum and cortex(mice), 638
Bidlack, J. M., see Jiang, Q., 1021Bigelow, G. E., see Preston, K. L., 813
Bis(5-amidino-2-benzimidazolyl)methane,related amidines and, reversible in-hibitors, mast cell tryptases (dogs),676
Bladder, initiation of micturition reflex, pe-ripheral role, tachykinins (rats), 1327
Blood-brain barrier, brain extracellularfluid/cerebrospinal fluid, distribu-tional transport kinetics, zidovudine(rabbits), 899
Blood pressure
acute and chronic hypertensive mecha-
nism, ketanserin (rats), 129hormonal and cardiovascular effects, lo-
sartan (monkeys), 6moxonidine, selective ligand, 11-imidazo-
line sites (cattle), 172
BMS 180,291binding and function, platelets (humans),
1387
pharmacological profile (humans, rats,cattle, mice, pigs, guinea pigs), 570
BMY 7378, induction of hypothermia, 5-
HT1A receptor-mediated activity
(rats), 1364
Bobelis, D. J. and Balster, R. L.: Pharma-cological specificity of the discrimi-native stimulus properties of 2-amino-4,5-(1,2-cyclohexyl)-7-phos-phonoheptanoic acid, a competitiveN-methyl-D-aspartate receptor an-tagonist, 845
Bodelsson, M., T#{246}rnebrandt, K. and Ar-neklo-Nobin, B.: Endothelial relax-ing 5-hydroxytryptamine receptors inthe rat jugular vein: Similarity with5-hydroxytryptamine1� receptor, 709
Bon, C., see Mounier, C., 1460Bone
calcemic hormone- and growth factor-based resorption, suramin as inhibi-ton (mice), 579
prevention of changes, aminohydroxybu-tane bisphosphonate and clenbuterol,tail-suspended rats, 1071
Borosky, S. A., see Ferkany, J. W., 256
Boundy, V. A., Luedtke, R. R., Gallitano, A.L., Smith, J. E., Filtz, T. M., Kallen,R. G. and Molinoff, P. B.: Expressionand characterization of the rat D3dopamine receptor: Pharmacologicproperties and development of anti-
bodies, 1002Bourguignon, J.-J., see Hechler, V., 1406Bowen, W. D., see Wild, K. D., 831
Bradley, M. E., Kuenzli, K. A. and Buxton,I. L. 0.: Adenosine-stimulated con-traction in nonpregnant guinea pig
myometrium does not involve cyclo-oxygenase, 1033
BradykininBi and B2 kinin receptors, superior mes-
enteric artery smooth muscle cells(rabbits), 930
-induced plasma extravasation, adrenalmedullary modulation, intrathecalnicotine (rats), 839
1993 Index 1495
mediation of effects through B2 kinin re-ceptor, inhibition by antagonist Hoe140 (guinea pigs), 1124
Brainalpha-2 adrenoceptor subtypes (humans),
967antidopaminergic and neuroleptic-like ac-
tivities, ‘y-hydroxybutyrate ligands,
1406autoradiographic mapping, M3 muscarinic
receptors (rats), 415cerebellum and cortex, bicuculline, �S-
TBPS binding (mice), 638
cortical slices, cholinergic modulation,NMDA-evoked norepinephrine re-lease (rats), 282
differential effects of alkylating agents,multiple muscarinic receptor sub-types (rats), 521
discrimination and pharmacological char-acterization, I2-imidazoline sites,
RX821002 (humans, rats), 1187extracellular fluid/cerebrospinal fluid,
distributional transport kinetics, zi-
dovudine (rabbits), 899
modulation of low affinity binding sites,nucleotides (rats), 701
neuroanatomical sites, motivational ef-fects of opioids, conditioned placepreference paradigm (rats), 489
paraventricular nucleus/anterior hypo-thalamus, histamine release, norepi-nephrine (rats), 734
prepiriform cortex, manipulation of en-dogenous adenosine, seizure suscep-
tibility (rats), 1415
properties of epsilon opioid receptor (rats,guinea pigs, cows, pigs, chickens), 349
protein kinase C subtypes, inhibition bylead (rats), 757
quinpirole binding, dopamine D2 and D3receptors (rats), 991
striatal dopamine and acetylcholine re-lease, effects of quinpirole, B-HT 920and SND 919, 1344
synaptosomes, nicotinic receptor func-tion, stimulation of rubidium efflux
(mice),542Brain stem, nucleus tractus solitarius, mod-
ulation of afferent transmission, se-
lective opioid agonists (rats), 795Branch, R. A., see Abels, B. C., 1285Brecht, K. M., see Maxwell, D. M., 1085Brechue, W. F. and Maren, T. H.: Carbonic
anhydrase inhibitory activity and
ocular pharmacology of organic sul-famates, 670
Breese, C. R., D’Costa, A., Ingram, R. L.,Lenham, J. and Sonntag, W. E.:Long-term suppression of insulin-
like growth factor-i in rats after inutero ethanol exposure: Relationship
to somatic growth, 448Breuer, A., see J#{228}rbe,T. U. C., 561Brewer, J. A., see Smolen, T. N., 854
Brien, J. F., see Liu, Z., 1432Broeders, A., see Lundin, S., 783Bronchoalveolar lavage fluid, antigen-me-
diated eosinophilia, IgG1 sensitiza-tion (guinea pigs), 922
Bronchus, neurokinin A derivatives, agonistand antagonist properties, C-termi-nal amidation (guinea pigs, rabbits,
hamster, rats), 17Brooderson, R. J., see Wolf, M. E., 249
Broomfield, J., see Proud, D., ii24Brown, D. R., see Hammerbeck, D. M., 384Brown, D. R., see Traynor, T. R., 61Browning, M. D., see Firestone, J. A., 1206Buckner, C. K., Fishleder, R. I., Conklin, R.,
Will, J. A., Doran, 0. and Graziano,
F. M.: Pharmacologic modulation ofthe influence of the epithelium onimmunologic- and nonimmunologic-induced histamine release and con-traction in guinea pig superfused tra-cheal strips,717
Budipine, neurotransmitter release, centralnervous system tissue (rabbits), 889
Buprenorphineintermittent administration, cocaine self-
administration (monkeys), 530prevention and reversal of expression,
chronic etorphine-induced sensitiza-tion, adenylyl cyclase in neuro-blastoma cells, 368
Burns, L. A., Butterworth, L. F. and Mun-son, A. E.: Reversal of gallium arsen-ide-induced suppression of the anti-body response by a mixed disulfidemetabolite of meso-2,3-dimercapto-succinic acid, 695
Bussiere, J. L., Adler, M. W., Rogers, T. J.and Eisenstein, T. K.: Cytokine re-versal of morphine-induced suppres-sion of the antibody response, 591
Butelman, E. R., France, C. P. and Woods,J. H.: Apparent pA2 analysis on therespiratory depressant effects of al-fentanil, etonitazene, ethylketocycla-zocin (EKC) and Mr2033 in rhesusmonkeys, 145
Butelman, E. R. and Woods, J. H.: Effectsof clonidine, dexmedetomidine and
xylazine on thermal antinociceptionin rhesus monkeys, 762
Butterworth, L. F., see Burns, L. A., 695tert-Butylhydroperoxide, -induced inhibi-
tion, lipid peroxidation, endothelialcell calcium signaling (calves), 1063
Buxton, I. L. 0., see Bradley, M. E., 1033Byssinosis, exposure to cotton dust, altera-
tion in modulatory role, respiratory
epithelium (guinea pigs), 683
Caffeine, cholinergic agonist- and K�-in-duced cytosolic-free Ca’’ signals, se-cretion, adrenal chromaffin cells(pigs),770
Calciumcoexistence of histamine H1 and H2 recep-
tors, signal transduction pathways,intestinal muscle cells (guinea pigs),
598dynamics, alterations by U46619, car-
diomyocytes (rats), 336hormone- and growth factor-based bone
resorption, suramin as inhibitor(mice), 579
K�-induced cytosolic-free signals, effects
of caffeine, adrenal chromaffin cells(pigs),770
signaling by endothelial cells, tert-butyl-hydroperoxide-induced inhibition,lipid peroxidation (calves), 1063
Calcium channel blockersenergy level and stimulated insulin secre-
tion, islets of Langerhans (rats), 35nimodipine, zidovudine kinetics (mon-
keys), 315
Calcium channels
block of two types, chlordiazepoxide,neuroblastoma cells (mice), 22
cocaine sensitization of coronary arterycontractions, mechanism, drug-in-duced spasm (cattle), 1132
inhibition of Na�-Ca� exchanger, anoxiaand glucopenia-induced aspartate re-lease, hippocampal slices (rats), 515
Canez, M. S., see King, T. S., 29
Cannabinoidsenantiomeric pairs, discriminative stim-
ulus effects, receptor binding (rats,
pigeons), 561natural and synthetic, aminoalkylindole
binding, cerebellum (rats), 1352
Canton, H., see Millan, M. J., 1364Captopril, peptidase inhibitors, neurogenic
plasma extravasation, nasal mucosa(rats), 509
Carbachol, activation of phospholipase C incortical slices, differential effects ofalkylating agents, muscarinic recep-
tor subtypes (rats), 521
Carbamate, comparison of antidote protec-tion against soman, pyridostigmine,
HI-6 and acetylcholinesterase, 1085Carbonic anhydrase, inhibitory activity,
ocular pharmacology, organic sulfa-
mates (rabbits), 670
Carcinoma, VX-2, antitumor effects ofTNP-470, microspheres and oil so-lution (rabbits), 469
Cardiomyocytes, calcium dynamics, altera-tionsby U46619 (rats),336
Cardiotoxicity, flecainide, modulation of so-dium channel blocking actions, ex-
tracellular sodium, 1160Cardiovascular system, pharmacological
profile of FR139317, ETA receptorantagonist (pigs), 1040
Carlisi, V. J., see Wild, K. D., 831Carr, D. J. J., Gebhardt, B. M. and Paul, D.:
Alpha adrenergic and Mu-2 opioidreceptors are involved in morphine-
induced suppression of splenocytenatural killer activity, 1179
Castle, N. A. and Slawsky, M. T.: Charac-terization of 4-aminopyridine blockof the transient outward K� currentin adult rat ventricular myocytes,1450
Cataplexy, control of, alpha-i receptor sub-type, narcolepsy (dogs), 1079
Catatonia, muscle rigidity, alfentanil-in-
duced antinociception, fl-funaltrex-amine and naloxonazine (rats), 739
Catechol compounds, pharmacological in-duction, physiologically active nervegrowth factor (rats), 321
Caudate nucleus, alpha-2 adrenoceptor sub-types (humans), 967
Caughey, G. H., Raymond, W. W., Bacci,E., Lombardy, R. J. and Tidwell, R.R.: Bis(5-amidino-2-benzimidazo-lyl)methane and related amidines arepotent, reversible inhibitors of mast
cell tryptases, 676Cederbaum, A. I., see Wu, D., 1468
Central nervous system
adrenal medullary modulation, bradyki-
nm-induced plasma extravasation,intrathecal nicotine (rats), 839
binding sites, cocaine-induced seizures,lethality, 1333
1496 Index Vol. 264
budipine effects, neurotransmitter release(rabbits), 889
Centurioni, M. G., see Alaoui-Jamali, M. A.,1299
Cerebellar granule cellsantisense oligodeoxynucleotide to mes-
senger RNAs, receptors with seventransmembrane spanning regions(rats), 423
muscarinic receptor-coupled phosphoino-sitide turnover, tetrahydroaminoac-ridine (rats), 463
Cerebellum
aminoalkylindole binding (rats), 1352
bicuculline-produced regional differences,
modulation of �S-TBPS binding,various agents (mice), 638
Cerebrospinal fluid, brain extracellularfluid, distributional transport kinet-ics, zidovudine (rabbits), 899
CGS 19755, excitatory amino acid agonists,dipsogenic effects (pigeons), 918
Chaki, K., see Ueki, S., 152Chen, H., Hamel, F. G., Siford, G. and Duck-
worth, W. C.: Alteration of rat he-patic insulin metabolism by glyburideand glipizide, 1293
Chen, J. B., Pillar, J. S., Shirley, J. T.,Showell, H. J., Watson, J. W. andCohan, V. L.: Antigen-mediated pul-monary eosinophilia in immunoglob-ulin G1-sensitized guinea pigs: Eosin-ophil peroxidase as a simple specificmarker for detecting eosinophils inbronchoalveolar lavage fluid, 922
Chen, L., see Yasumori, T., 89Chen, S. G., see Murakami, K., 757Chiamvimonvat, N., see Wang L., 1056Chiba, K., see Echizen, H., 1425Chiba, S., see Nakane, T., 1253Chinn, K.: Two delayed rectifiers in guinea
pig ventricular myocytes distin-guished by tail current kinetics, 553
Chiodo, L. A., see Pitts, D. K., 616Chlordiazepoxide, block of two types of cal-
cium channels, neuroblastoma cells
(mice), 22Chloride
electrolyte transport, inflammatory me-diators, distal colon epithelium(pigs), 61
neurally mediated action of leukotrienes,ion transport, distal colon (guineapigs), 384
Chloride channelscontractile effects of nucleotides, trachea
(guinea pigs), 210
relaxant effects of nucleotides, trachea(guinea pigs), 217
m-Chlorophenylbiguanide, 1-phenylbiguan-
ide and, behavioral effects (rats),1440
6-Chloropurine, detection and mechanismsof formation, S-(6-puri-nyl)glutathione, 6-mercaptopurine
(rats), 41
Cho, A. K., Hiramatsu, M., Schmitz, D. A.,Vargas, H. M. and Landaw, E. M.: Abehavioral and pharmacokineticstudy of the actions of phenylcycloh-exyldiethylamine and its active me-tabolite, phenylcyclohexylethylam-me, 1401
Cholecystokinin, FK506 characterization
and effects, exocytotic function, pan-creatic acini (rats), 873
Cholecystokinin-B, diphenylpyrazolidone,antagonists, midbrain dopamine neu-rons (rats), 480
Choline, presynaptic cholinergic actions,DuP 996 (rats), 910
Choroid plexus, chronic clozapine treat-
ment, decreased 5-HT1� receptordensity (rats), 1262
Chotinaruemol, S., see Miller, M. J. S., 11Chowdhury, P., see Doi, R., 873Christen, M. 0., see Ernsberger, P., 172Chuang, D.-M., see Sunaga, K., 463Cicero, T. J., Nock, B. and O’Connor, L.:
Naloxone does not reverse the inhib-itory effect of morphine on luteiniz-ing hormone secretion in prepubes-cent male rats, 47
Cicero, T. J., see Nock, B., 349Cimetidine, histamine release and contrac-
tion, influence ofepithelium, tracheal
strips (guinea pigs), 717Cisapride
gastroprokinetic activity of nizatidine(dogs, rats), 152
5-hydroxytryptamine and, motility in an-trum (dogs), 79
Clark, D. A., see Miller, M. J. S., 11Clarke, D. and Garg, L. C.: Alpha-2 adre-
nergic receptors in inner medullarycollecting duct cells of the rabbit kid-ney, 879
Clarke, D. E., see Waikar, M. V., 654Clenbuterol, aminohydroxybutane bisphos-
phonate and, prevention of bonechanges, retardation of muscle atro-
phy (rats), 1071Clineschmidt, B. V., see Pettibone, D. J.,
308
Clonidine
dexmedetomidine and ST-91, chronicspinal infusion, alpha-2 adrenoceptorsubtypes, 327
dexmedetomidine and xylazine, thermalantinociception (monkeys), 762
moxonidine, selective ligand, 11-imidazo-line sites (cattle), 172
Clozapine, decreased 5-HT1� receptor den-sity, comparison with haloperidol,choroid plexus (rats), 1262
Cocainechronic disruption of estrous cyclicity,
dose-dependent effects (rats), 29-induced seizures and lethality, central
nervous system binding sites, 1333self-administration, intermittent bupren-
orphine administration (monkeys),
530sensitization of coronary artery contrac-
tions, mechanism, drug-inducedspasm (cattle), 1132
tolerance and cross-tolerance (rats), 183Coffman, T. M., see Spurney, R. F., 584Cohan, V. L., see Chen, J. B., 922Cohen, M. L., see Cushing, D. J., 193Cohen, M. L., see Watts, S. W., 271
Colitis, experimental, epidermal growth fac-tor (rats), 984
Collins, A. C., see Marks, M. J., 542
Colombo, G., see Grant, K. A., 1241Colon
distal, neurally mediated action of leuko-trienes, ion transport (guinea pigs),384
distal epithelium, electrolyte transport,inflammatory mediators (pigs), 61
motility, cyclic nucleotide phosphodies-terase isozymes (dogs), 801
Colpaert, F. C., see Koek, W., 746Conklin, R., see Buckner, C. K., 717Connell, T. A., see Zhou, L.-W., 824
Cook, M. J., see Pettibone, D. J., 308Cortex, bicuculline-produced regional dif-
ferences, modulation of �S-TBPSbinding, various agents (mice), 638
Cosentino, M., see de Ponti, F., 789Cotton dust, alteration in modulatory role,
respiratory epithelium (guinea pigs),683
Couch, S. J., see DeGraff, G. L., 6Crema, A., see de Ponti, F., 789Crosland, R. D.: Effect of arachidonic acid
on twitch tension of the rat phrenicnerve-diaphragm, 1311
Cross, H. S., see Farsoudi, K. H., 579Crouch, J., see Badger, T. M., 438, 938Crouch, J., see Ronis, M. J. J., 944Cusack, B., see Di Paola, E. D., 1Cushing, D. J. and Cohen, M. L.: Serotonin-
induced contraction in porcine coro-nary artery: Use of ergolines to sup-port vascular 5-hydroxytryptamine2-
receptor heterogeneity, 193Cyclic adenosine monophosphate phospho-
diesterase, antidepressant-like ef-fects of rolipram, behavior, differen-tial reinforcement of low responserate (rats), 1168
Cyclic AMPaccumulation, bicarbonate-induced sen-
sitization, astrocytoma cells (hu-mans), 1211
coexistence of histamine H1 and H2 recep-tors, signal transduction pathways,intestinal muscle cells (guinea pigs),598
coupling of beta-i and beta-2 adrenocep-tors, connecting tubules, nephron(rabbits),105
decreased sensitivity, generation of mem-ory splenic CTL, aged mice, i381
extracellular, vasodilation, coronary ar-tery (dogs), 1253
inner medullary collecting duct cells, a!-pha-2 adrenergic receptors (rabbits),879
Cyclic GMP, autonomic nervous system, ni-tric oxide synthase, ileum (dogs), 234
Cyclo-oxygenase, lack of involvement, aden-osine-stimulated contraction, non-pregnant myometrium (guinea pigs),1033
Cytochrome P450chronic intragastric ethanol infusion, ep-
isodic ethanol excretion (rats), 93815 forms, regio- and stereoselective pro-
pranolol metabolism, liver (rats), 226
hepatic isozymes, chronic ethanol, growthhormone secretion (rats), 438
lack of involvement, metabolic activationof glyceryl trinitrate, aorta (rabbits),
1432repression of drug-metabolizing enzymes,
interleukin i�3, arthritis (rats), 1012stereoselective metabolism of mepheny-
tom, species differences (rats, rab-bits, dogs, monkeys, humans), 89
Cytochrome P450 2E1
1993 Index 1497
induction, alcohol exposure, two-stepmechanism (rats), 944
induction by pyrazole and 4-methylpyra-zole, liver, neonates (rats), 1468
Cytochrome P450 monooxygenase, distinctsignal transduction pathways, angio-tensin II, gastric smooth muscle(guinea pigs), 958
Cytokines, reversal of morphine-inducedsuppression, antibody response(mice), 591
Cytotoxic T-lymphocytes, memory splenic,decreased sensitivity to cAMP, agedmice, 1381
Czachura, J. F., see Rasmussen, K., 480
Dallman, M. F., see Miao, F. J.-P., 839Daly, D. A., see Youngren, K. D., 289
D’Ambra, T. E., see Kuster, J. E., 1352DAMGO, selective opioid agonists, modu-
lation of afferent transmission, nu-cleus tractus solitarius (rats), 795
Damon, T. H., see Ernsberger, P., 172D’Angelo, L., see de Ponti, F., 789Daniel, E. E., see Kostka, P., 234Daniel, E. E., see Shimamoto, Y., 201DAU 6285, pharmacological analyses at 5-
HI’4 receptor, tunica muscularis mu-cosae, ileum (rats, guinea pigs), 654
D’Costa, A., see Breese, C. R., 448Deadwyler, S. A., see Heyser, C. J., 294DeBernardis, J. F., see Firestone, J. A., 1206Defibrotide, stimulation of endogenous
prostacyclin, protection from is-
chemic injury, myocardium (pigs),397
DeGraff, G. L., Pals, D. T., Couch, S. J. andLawson, J. A.: Hormonal and cardi-ovascular effects of losartan (Du-P753), an angiotensin receptor an-tagonist, in nonhuman primates, 6
Dement, W. C., see Nishino, S., 1079O-Demethyl-encainide, interaction of so-
dium and potassium channel block-ers, papillary muscle (guinea pigs),1056
de Ponti, F., Einaudi, A., Cosentino, M.,
D’Angelo, L., Lecchini, S., Frigo, G.M. and Crema, A.: Differential effectsof antimuscarinic agents on intes-tinal motility in the conscious dog,789
De Ridder, W. J. E. and Schuurkes, J. A. J.:Cisapride and 5-hydroxytryptamineenhance motility in the canine an-trum via separate pathways, not in-volving 5-hydroxytryptamine recep-tors, 79
Des-Ar�-bradykinin, Bi and B2 kinin re-ceptors, superior mesenteric arterysmooth muscle cells (rabbits), 930
Desipramine, impairment oflatent learning,dopaminergic agonists (mice), 122
De Souza, E. B., see Katz, J. L., 183DeSouza, E. B., see Levant, B., 991Dexmedetomidine
clonidine and xylazine, thermal antinoci-ception (monkeys), 762
ST-91 and clonidine, chronic spinal in-fusion, a4,ha-2 adrenoceptor sub-types, 327
Diabetes mellitus, pharmacokinetics, 70-kil-odalton fluorescein-dextran (rats),662
Diaphragm, phrenic nerve, effect of arachi-donic acid, twitch tension (rats), 1311
Diazepam
-like independence, lack of induction,long-term treatment with abecarnil
(mice), 1395modulation of �S-TBPS binding, bicu-
culline-produced regional differ-ences, cerebellum and cortex (mice),
638Diet
chronic alcohol exposure, two-step mech-anism, cytochrome P450 CYP 2E1induction (rats), 944
chronic intragastric ethanol infusion, ep-isodic ethanol excretion (rats), 938
Dihydropyridine, renal nerve stimulation-induced antinatriuresis, suppressionby TMB-8 (dogs), 117
1,25-Dihydroxyvitamin D3, calcemic hor-mone- and growth factor-based boneresorption, suramin as inhibitor(mice), 579
Diltiazem, energy level and stimulated in-
sulin secretion, islets of Langerhans(rats), 35
meso-2,3-Dimercaptosuccinic acid, mixeddisulfide metabolite, reversal, galliumarsenide-induced suppression of an-tibody response (mice), 695
Di Paola, E. D., Cusack, B., Yamada, M.
and Richelson, E.: Desensitizationand down-regulation of neurotensinreceptors in murine neuroblastomaclone N1E-115 by [D-Lys8] neuroten-sin(8-13), 1
Diphenylpyrazolidinone, cholecystokinin-Band -A antagonists, electrophysiolog-ical effects, midbrain dopamine neu-rons (rats), 480
Dipropyl-5-carboxamidotryptamine, tra-cheal contractile serotonergic recep-tor, 5-HT2 receptor (guinea pigs), 271
Di Renzo, G., see Amoroso, S., 515Discriminative stimulus
ethanol effects, training dose, substitu-tion of NMDA antagonists (rats),1241
fentanyl from saline, phencyclidine-typedrugs (rats), 746
pharmacological specificity, 2-amino-4,5-
(1,2-cyclohexyl)-7-phosphonohep-tanoic acid (rats), 845
receptor binding of enantiomeric pairs(rats, pigeons), 561
triazolam, selectivity and sensitivity,novel-response procedure (humans),
360Disopyramide, mono-N-dealkylation me-
tabolism, potent inhibitory effect,erythromycin and other macrolideantibiotics (humans), 1425
Dithiothreitol, neuronal nicotinic acetyl-choline receptors, redox effects, ner-eistoxin (chicks), 689
Diuresis, furosemide, renal dopamine syn-thesis (rats), 1377
Diuretics, IC! 206,970, renal site of action,micropuncture study (rats), 604
DNA, complementary, cloning and expres-sion, uridine diphosphate-glucurono-syltransferase glucuronidating car-boxylic acid-containing drugs (hu-mans), 475
Doan, T. N., see Elliott, S. J., 1063Doctor, B. P., see Maxwell, D. M., 1085Doi, R., Inoue, K., Chowdhury, P. and Ray-
ford, P. L.: Biochemical characteriza-tion of the effects of FK506 on signaltransduction in exocytotic functionof rat pancreatic acini, 873
Domino, E. F. and Sheng, J.: N-methyl-D-asparate receptor antagonist and do-pamine D1 and D2 agonist interac-tions in 1-methyl-4-phenyl-i,2,5,6-
tetrahydropyridine-induced hemi-parkinsonian monkeys, 221
Dopamine
acetylcholine release and, quinpirole,
comparisons with B-HT 920 andSND 919, 1344
agonistsimpairment of latent learning (mice),
122
role of forebrain, repeated ampheta-mine administration (rats), 616
agonist YM435, renal microvascular ac-tions(rats), 1154
antidopaminergic and neuroleptic-like ac-tivities, -y-hydroxybutyrate ligands,1406
budipine effects, neurotransmitter re-lease, central nervous system tissue(rabbits), 889
cocaine tolerance and cross-tolerance(rats), 183
D2 agonists, ipsilateral rotations, AF64Alesions of striatum (mice), 824
D1 and D2 agonist interactions, NMDAreceptor antagonist, 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridineinduction (monkeys), 221
enhanced release, autoreceptor subsensi-tivity, amphetamine sensitization(rats),249
midbrain neurons, electrophysiologicaleffects, diphenylpyrazolidinone cho-lecystokinin-B and -A antagonists(rats), 480
outflow in nucleus accumbens, distinctactions, endogenous excitatoryamino acids (rats), 289
renal synthesis, diuretic effect of furose-mide (rats), 1377
synthesis in kidney, role of sodium (rats),406
Doran, 0., see Buckner, C. K., 717Dorsal raphe nucleus, methoxy-chroman de-
rivatives, agonist properties, central5-HT1A receptors (rats), 863
Dosaka-Akita, K., Tortella, F. C., Holaday,J. W. and Long, J. B.: The kappaopioid agonist U-50,488H antago-nizesrespiratoryeffectsof mu opioid
receptor agonists in conscious rats,631
Douse, T. P., see Homma, S., 105Doxorubicin, reversal of resistance by Rol 1-
2933 (rats), 1299Drieze, J. M., see Mello, N. K., 530Duan, D., Fermini, B. and Nattel, S.: Potas-
sium channel blocking properties ofpropafenone in rabbit atrial myo-cytes, 1113
Duckles, S. P., see Li, Z., 1305Duckworth, W. C., see Chen, H., 1293Duff, H. J., see Wang L., 1056DuP 753, EXP 3174 and, inhibitory effects
on responses to angiotensin II, hind-
quarters vascular bed (cats), 1104DuP 996, presynaptic cholinergic actions
(rats), 910
1498 Index Vol. 264
E-3330, protective effect, galactosamine-in-duced hepatitis (rats), 496
E-403i, two delayed rectifiers, ventricularmyocytes, tail current kinetics(guinea pigs), 553
Eager, S., see Jia, H., 1275Echizen, H., Kawasaki, H., Chiba, K., Tani,
M. and Ishizaki, T.: A potent inhibi-tory effect oferythromycin and othermacrolide antibiotics on the mono-N-dealkylation metabolism of diso-pyramide with human liver micro-somes, 1425
Ehrhardt, J.-D., see Hechler, V., 1406Eicosanoid, glomerular thromboxane recep-
tors, lupus nephritis (mice), 584Einaudi, A., see de Ponti, F., 789Eisenstein, T. K., see Bussiere, J. L., 591Electrolytes, transport across distal colon
epithelium, inflammatory mediators(pigs), 61
Elfarra, A. A., see Hwang, I.-Y., 41Elliott, S. J., Doan, T. N. and Schilling, W.
P.: Role of lipid peroxidation in tert-butylhydroperoxide-induced inhibi-tion of endothelial cell calcium sig-naling, 1063
El-Mas, M. M. and Abdel-Rahman, A. A.:Direct evidence for selective involve-ment of aortic baroreceptors inethanol-induced impairment of bar-oreflex control of heart rate, 1198
Eltoprazine, induction of hypothermia, 5-HTIA receptor-mediated activity
(rats), 1364Emmett-Oglesby, M. W., see Prather, P. L.,
622Endo-6-methoxy-8-methyl-8-azabicy-
clo[3.2.i]oct-3-yl-2,3-dihydro-2 -oxo-1H-benimidazole-1-carboxylate hy-drochloride, see DAU 6285
�9-Endorphin
naloxone-resistant receptors, protein ki-nase C activation, U937 cells, 276
properties ofepsilon opioid receptor, brain(rats, guinea pigs, cows, pigs, chick-ens), 349
Endothelial cells, calcium signaling, lipidperoxidation, tert-butylhydroperox-ide-induced inhibition (calves), 1063
EndothelinETA receptor antagonist, pharmacological
profile, FR139317 (pigs), 1040renal microvascular actions of YM435
(rats), 1154Endothelin- 1, precontraction, contraction
with rauwolscine, mesenteric artery(dogs), 201
Endothelium, relaxation, 5-HT receptors,jugular vein (rats), 709
Enero, M. A., see Nowicki, S., 1377Eosinophilia, pulmonary, antigens, IgGi
sensitization (guinea pigs), 922
Epidermal growth factorbone resorption, suramin as inhibitor
(mice), 579distinct signal transduction pathways, an-
giotensin II, gastric smooth muscle(guinea pigs), 958
experimental colitis (rats), 984Epithelium
distal colon, electrolyte transport, inflam-matory mediators (pigs), 61
histamine release and contraction, phar-
macologic modulation, tracheal strips(guinea pigs), 717
relaxant effects of nucleotides, trachea(guinea pigs), 217
respiratoryalteration in modulatory role, exposure
to cotton dust (guinea pigs), 683
contractile effects, nucleotides (guineapigs), 210
Epstein, M., see Takenaka, T., 1154Ereci#{241}ska,M., see Ohta, M., 35Ergolines, serotonin-induced contraction of
coronary artery, vascular 5-HT2-re-ceptor heterogeneity (pigs), 193
Ernsberger, P., Damon, T. H., Graff, L. M.,Schafer, S. G. and Christen, M. 0.:Moxonidine, a centrally acting anti-hypertensive agent, is a selective ii-gand for 11-imidazoline sites, 172
Errett, C. J., see Thomas G. R., 67Erythromycin, other macrolide antibiotics
and, potent inhibitory effect, mono-N-dealkylation metabolism of diso-pyramide (humans), 1425
Escaf, S., see Ricci, A., 431Esophagus, tunica muscularis mucosae and
ileum, pharmacological analyses,DAU 6285 (rats, guinea pigs), 654
Estradiol benzoate, hormonal regulation of
acetohexamide reductase, postnataldevelopment, liver and kidney (rats),166
Estrous, cyclicity, chronic cocaine disrup-tion, dose-dependent effects (rats),29
Ethanolr-aminobutyric acid-induced depressions,
cerebellar Purkinje neurons (rats),951
chronic, growth hormone secretion, he-patic cytochrome P450 isozymes(rats), 438
discriminative stimulus effects, training
dose, substitution of NMDA antago-nists (rats), 1241
episodic excretion, chronic intragastricethanol infusion (rats), 938
-induced desensitization of adenylate cy-clam, adenosine receptor, GTP-bind-ing proteins, 977
-induced impairment of baroreflex con-trol, aortic baroreceptors, heart rate(rats), 1198
in utero exposure, long-term suppression,insulin-like growth factor-i (rats),448
i,1,1-trichloroethane-produced physicaldependence, effects of drugs and va-pors, withdrawal (mice), 726
Ethylketocyclazocineproperties ofepsilon opioid receptor, brain
(rats, guinea pigs, cows, pigs, chick-ens), 349
respiratory depressant effects, apparentpA2 analysis (monkeys), 145
Etonitazene, respiratory depressant effects,apparent pA2 analysis (monkeys),145
Etorphine, -induced sensitization of adeny-lyl cyclase, buprenorphine preven-tion and reversal, neuroblastomacells, 368
Evans, B. E., see Pettibone, D. J., 308Evans, E. B. and Balster, R. L.: Inhaled 1,
1,i-trichlorethane-produced physical
dependence in mice: Effects of drugsand vapors on withdrawal, 726
Ewing, J. F., see Maines, M. D., 457
EXP 3174, DuP 753 and, inhibitory effectson responses to angiotensin II, hind-quarters vascular bed (cats), 1104
Eye, ocular pharmacology of organic sulfa-mates, carbonic anhydrase inhibitoryactivity (rabbits), 670
Faili, A., see Mounier, C., 1460Fain, J. N., see Sall#{233}s,J., 521Farnham, D. A., see Marks, M. J., 542Farsoudi, K. H., Pietschmann, P., Cross, H.
S. and Peterlik, M.: Suramin is a
potent inhibitor of calcemic hor-mone- and growth factor-inducedbone resorption in vitro, 579
Fattaccini, C.-M., see Kidd, E. J., 863
Fatty acidseffect of arachidonic acid on twitch ten-
sion, phrenic nerve-diaphragm (rats),
1311
imbalance between glycolysis and glucoseoxidation, aerobic reperfusion, is-chemic heart (rats), 135
inhibition of brain protein kinase C sub-types, lead (rats), 757
Fedan, J. S., Belt, J. J., Yuan, L.-X. andFrazer, D. 0.: Contractile effects ofnucleotides in guinea pig isolated,perfused trachea: Involvement of res-piratory epithelium, prostanoids andNa� and C� channels, 210
Fedan, J. S., Belt, J. J., Yuan, L.-X. andFrazer, D. G.: Relaxant effects of nu-cleotides in guinea pig isolated, per-fused trachea: Lack of involvementof prostanoids, Cr channels andadenosine, 217
Fedan, J. S., see Smith, J. A., 683
Felbamate, anticonvulsant and neuropro-tectant action, strychnine-insensi-tive glycine receptors, 1248
Fener, P., see Ferrari, L., 1012Feng, G., see Murakami, K., 757
Fentanyl, discrimination from saline, phen-cyclidine-type drugs (rats), 746
Ferkany, J. W., Hamilton, G. S., Patch, H.J., Huang, Z., Borosky, S. A., Bednar,D. L., Jones, B. E., Zubrowski, H.,Willetts, J. and Karbon, E. W.: Phar-macological profile of NPC 17742[2R, 4R, 5S-(2-Amino-4,5-(1,2-Cy-clohexyl)-7-PhosphoneptanoicAcid)J, a potent, selective and com-petitive N-methyl-D-aspartate recep-ton antagonist, 256
Fermini, B., see Duan, D., 1113Fermini, B., see Ranger, S., 1160Fernandes, H., see Soares-[da]-Silva, P., 406Ferrari, L., Jouzeau, J. -Y., Gillet, P., Her-
ber, H., Fener, P., Batt, A. -M. andNetter, P.: Interleukin-lfl differen-tially represses drug-metabolizingenzymes in arthritic female rats, 1012
Fetal alcohol syndrome, in utero ethanolexposure, long-term suppression, in-sulin-like growth factor-i (rats), 448
Fibiger, H. C., see Robertson, G. S., 1344Fibrogen, optimized thrombolysis, tissue-
type plasminogen activator, embolicstroke (rabbits), 67
Filtz, T. M., see Boundy, V. A., 1002Firestone, J. A., Gerhardt, G. A., De-
Bernardis, J. F., McKelvy, J. F. and
1993 Index 1499
Browning, M. D.: Actions of A-75200,a novel catecholamine uptake inhib-itor, on norepinephrine uptake andrelease from bovine adrenal chromaf-fin cells, 1206
Fishleder, R. I., see Buckner, C. K., 717FK506, biochemical characterization, signal
transduction, exocytotic function ofpancreatic acini (rats), 873
Flecainide, modulation of sodium channelblocking actions, extracellular so-dium, 1160
Flumazenil, benzodiazepine withdrawal,conflicting evidence regarding effi-cacy, ondansetron (rats), 622
Flunarizine, energy level and stimulated in-sulin secretion, islets of Langerhans(rats), 35
Fluorescein-dextran, 70-kilodalton, phar-macokinetics, diabetes mellitus(rats), 662
Flynn, D. L., see Gullikson, G. W., 240Ford, A. P. D. W., see Waikar, M. V., 654Forebrain, responsiveness of nigrostriatal
dopamine neurons, dopamine ago-nists, repeated amphetamine admin-istration (rats), 616
Forsberg, E. J., see Xu, Y., 770Forskolin
inner medullary collecting duct cells, a!-pha-2 adrenergic receptors (rabbits),879
isobutylmethylxanthine and, delta opioidreceptor activity, NG1O8-i5 cells,1474
Forster, J., see Takenaka, T., 1154FR139317, pharmacological profile (pigs),
1040France, C. P., see Butelman, E. H., 145Franklin, P. H., see Zhang, G., 1415Frazer, D. G., see Fedan, J. S., 210, 217Fraser, D. G., see Smith, J. A., 683Freeman, A. S., see Pitts, D. K., 616Freidinger, R. M., see Pettibone, D. J., 308Frey, K. A., see Zubieta, J. K., 415
Frigo, G. M., see de Ponti, F., 789Fruhstorfer, B., see Nishino, S., 1079Fujita, S., Umeda, S., Funae, Y., Imaoka, S.,
Hiroko, A., Ishida, R., Adachi, T.,Masuda, M., Kazusaka, A. and Su-zuki, T.: Regio-and stereoselectivepropranolol metabolism by 15 formsof purified cytochromes P-450 fromrat liver, 226
Funae, Y., see Fujita, S., 226fl-Funaltrexamine, naloxonazine and, alfen-
tanil-induced antinociception, mus-cle rigidity (rats), 739
Furosemide, diuretic effect, renal dopaminesynthesis (rats), 1377
Furukawa, K., see Oka, M., 158Furukawa, S., see Kaechi, K., 321Furukawa, T., see Jia, H., 1275Furukawa, Y., see Kaechi, K., 321
Galactosamine, -induced hepatitis, protec-tive effect of E3330 (rats), 496
Galligan J. J.: Differential inhibition of cho-linergic and noncholinergic neuro-genic contractions by mu opioid anda�pha-2 adrenergic agonists in guineapig lleum, 375
Gallitano, A. L., see Boundy, V. A., 1002Gallium arsenide, -induced suppression of
antibody response, reversal, mixed
disulfide metabolite of meso-2,3-di-mercaptosuccinic acid (mice), 695
Gallo, J. M., Swagler, A. H., Mehta, M. andQian, M.: Pharmacokinetic evalua-
tion of drug interactions with anti-
human immunodeficiency virusdrugs. VI. Effect on the calciumchannel blocker nimodipine on zido-vudine kinetics in monkeys, 315
Garcia-Sevilla, J. A., see Miralles, A., 1187Garg, L. C., see Clarke, D., 879Gaskill, S., see King, T. S., 29
Gastric emptying, solid and liquid meals,gastrointestinal motility, SC-49518(dogs), 240
Gastrointestinal tractgastroprokinetic activity of nizatidine
(dogs, rats), 152ileum, autonomic nervous system, nitric
oxide synthase (dogs), 234motility in antrum, cisapride and 5-hy-
droxytryptamine (dogs), 79GBR 12909
cocaine tolerance and cross-tolerance(rats), 183
impairment of latent learning (mice), 122
Gebhardt, B. M., see Carr, D. J. J., 1179Gellai, M., see Nambi, P., 345
Gender differences, survival during hypoxia,cholinergic and anticholinergic drugeffects (mice), 1146
Genistein, distinct signal transduction path-ways, angiotensin II, gastric smoothmuscle (guinea pigs), 958
George, F. H., see Ritz, M. C., 1333
Gerber, N., see Apseloff G., 1071Gerhardt, G. A., see Firestone, J. A., 1206Gillet, P., see Ferrari, L., 1012
Giordano, A. L., see Nock, B., 349Girten, B., see Apseloff G., 1071Giuliani, S., see Lecci A., 1327Glaucoma, carbonic anhydrase inhibitory
activity, ocular pharmacology, or-ganic sulfamates (rabbits), 670
Glaum, S. H., see Rhim, H., 795
Glibenclamide, modulation of low affinitybinding sites, nucleotides, brain(rats), 701
Glipizide, glyburide and, alteration, hepaticinsulin metabolism (rats), 1293
Glomerular filtrate rate, postischemic renalvasoconstriction, interaction, throm-boxane A2 and angiotensin II (dogs),1285
Glucopenia, -induced aspartate release, in-hibition of Na�-Ca� exchanger, hip-pocampal slices (rats), 515
Glucoseenergy level and stimulated insulin secre-
tion, Ca� channel blockers, islets of
Langerhans (rats), 35oxidation and glycolysis, fatty acids, aero-
bic reperfusion of ischemic hearts(rats),135
Glutamate, distinct actions of endogenousexcitatory amino acids, outflow of do-pamine, nucleus accumbens (rats),289
-y-Glutamyltransferase, repression of drug-metabolizing enzymes, interleukin1/I, arthritis (rats), 1012
-y-Glutamyltranspeptidase, tubular secre-tion and reabsorption, mercury com-pounds, kidney (mice), 776
Glutathione, tubular secretion and reab-
sorption, mercury compounds, kid-ney (mice), 776
Glutathione S-transferase, detection andmechanisms of formation, S-(6-puri-nyl)glutathione and 6-mercaptopu-nine, 6-chloropurine (rats), 41
Glyburide, glipizide and, alteration, hepaticinsulin metabolism (rats), 1293
Glyceryl trinitrate, metabolic activation,lack of involvement of cytochnome P-450, aorta (rabbits), 1432
Glycine, strychnine-insensitive receptors,anticonvulsant and neuroprotectantaction, felbamate, 1248
Glycolysis, glucose oxidation and, fattyacids, aerobic reperfusion of ischemichearts (rats), 135
Gobaille, S., see Hechler, V., 1406
Gobert, A., see Millan, M. J., 1364Goldenberg, H., see Webb, M. L., 1387Goldman, D. W., see Proud, D., 1124
Goldstein, B., see Gullikson, G. W., 240Gonadotropins, chronic cocaine disruption,
estrous cyclicity, dose-dependent ef-
fects (rats), 29Gonzales, R. A., Roper, L. C. and West-
brook, S. L: Cholinergic modulationof N-methyl-D-aspartate-evoked[3H]norepinephrine release from ratcortical slices, 282
Goso, C., see Patacchini, H., 17
Gozlan, H., see Kidd, E. J., 863GR 82,334, initiation of micturition reflex,
peripheral role, tachykinins (rats),1327
Grady, S. H., see Marks, M. J., 542Graff, L. M., see Ernsberger, P., 172
Grant, K. A. and Colombo, G.: Discrimina-tive stimulus effects ofethanol: effectof training dose on the substitutionof N-methyl-D-aspartate antago-nists, 1241
Gravity, tail-suspended rats, prevention ofbone changes, aminohydroxybutanebisphosphonate and clenbuterol,1071
Graziano, F. M., see Buckner, C. K., 717Grider, J. H., see Morini, G., 598Gniffiths, J. W., see Katz, J. L., 183Grigoriadis, D. E., see Levant, B., 991Growth hormone
secretion, chronic ethanol, hepatic cyto-chrome P450 isozymes (rats), 438
somatostatin receptor subtypes, anteriorpituitary cell line GH3 (rats), 110
GTP-binding proteins, ethanol-induced de-sensitization, adenylate cyclase, 977
Guanosine triphosphate, effects of ATP andrelated nucleotides, tone, mesentericresistance arteries (rats), 1234
Guanylate cyclase, -coupled receptors, al-tered neurotransmission, atrial natri-uretic factor (rabbits), 1227
Guardiola-Lemaitre, B., see Kidd, E. J., 863Guilleminault, C., see Nishino, S., 1079
Gullikson, G. W., Virina, M. A., Loeffler, R.F., Yang, D.-C., Goldstein, B., Wang,S.-X., Moummi, C., Flynn, D. L. andZabrowski, D. L.: SC-49518 enhancesgastric emptying of solid and liquidmeals and stimulates gastrointestinalmotility in dogs by a 5-hydroxytryptamine4 receptor mecha-nism, 240
Gummelt, D., see Tropea, M. M., 930
1500 Index Vol. 264
Hadv#{225}ry,P., see Roux, S. P., 501Haile, D., see Neely, C. F., 1315Haj-Dahmane, S., see Kidd, E. J., 863
Halaris, A. E., see Ordway, G. A., 967Haloperidol
chronic clozapine treatment, decreased 5-GT1� receptor density, choroid plexus(rats), 1262
pharmacological profile of AD-5423(mice, rats), 158
phencyclidine-type drugs, discriminationof fentanyl from saline (rats), 746
Haluska, G. J., see Pettibone, D. J., 308Hamel, F. G., see Chen, H., 1293Hamilton, G. S., see Ferkany, J. W., 256Hammerbeck, D. M. and Brown, D. R.:
Neurally mediated actions of leuko-trienes on ion transport in guinea pigdistal colon, 384
Hamon, M., see Kidd, E. J., 863Hampson, H. E., see Heyser, C. J., 294Hansson, K., see Lundin, S., 783Hanus, L., see J#{228}rbe,T. U. C., 561Harris, D. N., see Ogletree, M. L., 570Harris, D. N., see Webb, M. L., 1387Harrison, N. L., see Lovinger, D. M., 1097Hashimoto, Y., see Kaechi, K., 321Hatmi, M., see Mounier, C., 1460Hatzidimitriou, G., see Scanzello, C. H.,
1484
Hayashi, K., see Kaechi, K., 321Haycock, D. A., see Kuster, J. E., 1352Heart, ischemic, imbalance between glycol-
ysis and glucose oxidation, fatty acids(rats), 135
Heart rate, ethanol-induced impairment ofbaroreflex control, aortic barorecep-tors (rats), 1198
Heat shock proteins, induction of heme ox-ygenase-1 messenger RNA and pro-tein, ischemia/reperfusion, kidney(rats), 457
Hechler, V., Peter, P., Gobaille, S., Bour-guignon, J.-J., Schmitt, M., Ehr-hardt, J.-D., Mark, J. and Maitre, M.:-y-hydrooxybutyrate ligands possessantidopaminergic and neuroleptic-like activities, 1406
Hedberg, A., see Webb, M. L., 1387Hegde, S. S., see Waikar, M. V., 654Heinroth-Hoffmann, I., see Hoffmann, P.,
336Heme oxygenase-1, messenger RNA and
protein, induction by ischemia/reper-fusion, kidney (rats), 457
Hemiparkinsonism, i-methyl-4-phenyl-1,2,5,6-tetrahydropyridine induction,
NMDA receptor antagonist, dopa-mine D1 and D2 agonist interactions(monkeys), 221
Hemoproteins, lack of involvement of cyto-chrome P-450, metabolic activationof glyceryl trinitrate, aorta (rabbits),1432
Heparmn, coronary artery reperfusion andreocclusion, thrombolysis, tissue-type plasminogen activator (dogs),501
Hepatitis, galactosamine-induced, protec-tive effect of E3330 (rats), 496
Herber, H., see Ferrari, L., 1012Hers, A., see Bals-Kubik, H., 489Herzig, M. S., see Tropea, M. M., 930Heyser, C. J., Hampson, H. E. and Dead-
wyler, S. A.: Effects of delta-9-tetrah-
ydrocanninol on delayed match tosample performance in rats: Altera-tions in short-term memory associ-ated with changes in task specific
firing of hippocampal cells, 4, 29HI-6, pyridostigmine and acetylcholinester-
ase, comparison of antidote protec-tion, soman, 1085
Hietala, J., see Kuoppamki, M., 1262Higgins, G. A., Joharchi, N. and Sellers, E.
M.: Behavioral effects of the 5-hydroxytryptamine3 receptor ago-nists 1-phenylbiguanide and m-chlo-rophenylbiguanide in rats, 1440
Higgins, S. T., see Bickel, W. K., 360Higgins, S. T., see Rush, C. H., 1218Higuchi T., see Imamura, Y., 166Hiltunen, A. J., see J#{228}rbe,T. U. C., 561Hino, K., see Oka, M., 158Hippocampus
alpha-2 adrenoceptor subtypes (humans),967
delayed match to sample performance, #{244}-9-tetrahydrocannabinol (rats), 294
inhibition of Na�-Ca� exchanger, anoxia,glucopenia-induced aspartate release(rats), 515
muscarmic autoreceptor, pharmacologicalcharacterization (rats), 74
neurons, trichloroethanol-potentiatedsynaptic transmission, mediation byGABAA receptors, 1097
Hiroko, A., see Fujita, S., 226Hirota, K., see Nagakawa, J.-I., 496Hisa, H., see Ogasawara, A., 117Hishinuma, I., see Nagakawa, J.-I., 496Histamine
inflammatory mediators, electrolytetransport, distal colon epithelium(pigs), 61
norepinephrine release, paraventricularnucleus/anterior hypothalamus(rats), 734
release and contraction in tracheal strips,pharmacologic modulation, influenceon epithelium (guinea pigs), 717
Hoe 140, inhibition of B2 kinin receptormediation, bradykinin effects (guineapigs), 1124
Hoffman, A. and Levy, G.: Kinetics of drugaction in disease states. XLI. Effectof adrenalectomy on the hypnotic ac-tivity ofphenobarbital, the neurotox-icity of theophylline and pain sensi-tivity in rats, 859
Hoffman, B. B., see Thomas, J. M., 368Hoffmann, P., Heinroth-Hoffmann, I. and
Toraason, M.: Alterations by athromboxane A2 analog (U46619) of
calcium dynamics in isolated rat car-diomyocytes, 336
Hohlfeld, T., Strobach, H. and Schror, K.:Stimulation of endogenous prostacy-din protects the reperfused pig myo-cardium from ischemic injury, 397
Holaday, J. W., see Dosaka-Akita, K., 631Hollenberg, M. D., see Yang, S.-G., 958Holopainen, I. and Wojcik, W. J.: A specific
antisense oligodeoxynucleotide to
mRNAs encoding receptors withseven transmembrane spanning re-gions decreases muscarinic m2 and -y-aminobutyric acidB receptors in ratcerebellar granule cells, 423
Holzer, P., Schluet, W. and Maggi, C. A.:
Ascending enteric reflex contraction:Roles of acetylcholine and tachyki-
nins in relation to distension andpropagation of excitation, 391
Homma, S., Kusano, E., Takeda, S., Muray-ama, N., Asano, Y. and Douse, T. P.:Both beta-i and beta-2 adrenoceptorsare coupled to the cyclic AMP systemin connecting tubules of rabbit neph-ron, 105
Hooper, M. L., see Prather, P. L., 622Hori, Y., see Ueki, S., 152Howbert, J. J., see Rasmussen, K., 480Howell, R. E., Sickels, B. D. and Woeppel,
S. L.: Pulmonary antiallergic andbronchodilator effects of isozyme-se-lective phosphodiesterase inhibitorsin guinea pigs, 609
Hruby, V. J., see Wild, K. D., 831Huang, H.-Y., see Jackisch, H., 889Huang, J., see Badger, T. M., 438Huang, Z., see Ferkany, J. W., 256Hughes, J. H., see Bickel, W. K., 360Hughes, J. H., see Rush, C. H., 1218Human immunodeficiency virus, nimodi-
pine effect on zidovudine kinetics(monkeys), 315
Hwang, I.-Y. and Elfarra, A. A.: Detectionand mechanisms of formation of S-(6-Purinyl)glutathione and 6-mer-captopurine in rats given 6-chloro-purine, 41
Hydromorphone, pentazocine and, differ-ential naltrexone antagonism (hu-mans), 813
-y-Hydroxybutyrate, ligands, antidopami-nergic and neuroleptic-like activities,1406
5-Hydroxytryptamine, cisapride and, motil-ity in antrum (dogs), 79
Hypertensionacute and chronic mechanism, ketanserin
(rats), 129
renal site of action, ICI 206,970, micro-puncture study (rats), 604
Hypothalamus, anterior, histamine release,norepinephrine (rats), 734
Hypothermia, 5-HT1A receptor-mediatedactivity (rats), 1364
Hypoxia, survival during, cholinergic andanticholinergic drug effects, genderdifferences (mice), 1146
Ichihara, K., Nabeshima, T., Kameyama,T.: Dopaminergic agonists impair la-tent learning in mice: Possible mod-ulation by noradrenergic function,122
ICI 206,970, renal site of action, micropunc-ture study (rats), 604
Idazoxan, discrimination and pharmacolog-ical characterization, 12-imidazolinesites, brain (humans, rats), 1187
Igegami, H., see Kaechi, K., 321
Ileitis, chronic, amelioration, nitric oxidesynthase inhibition (rats), 11
Ileumautonomic nervous system, nitric oxide
synthase (dogs), 234cholinergic and noncholinergic neuro-
genic contractions, mu opioid and a!-
pha-2 adrenergic agonists (guineapigs), 375
neurokinin A derivatives, agonist and an-tagonist properties, C-terminal ami-
1993 Index 1501
dation (guinea pigs, rabbits, ham-sters, rats), 17
tunica muscularis mucosae and, pharma-cological analyses, DAU 6285 (rats,
guinea pigs), 654withdrawal responses, effects of NSAIDs,
brief exposure to morphine (guineapigs), 1028
Imamura, Y., Iwamoto, K., Yanachi, Y.,Higuchi, T. and Otagiri, M.: Postna-tal development, sex-related differ-ence and hormonal regulation of ace-
tohexamide reductase activities in ratliver and kidney, 166
Imaoka, S., see Fujita, S., 226Imidazoline, moxonidine, selective ligand
(cattle), 17212-Imidazoline, discrimination and pharma-
cological characterization, idazoxanand alpha-2 adrenoceptors,RX821002 in brain (humans, rats),1187
Immunoglobulin Gi, sensitization, antigen-mediated pulmonary eosinophilia(guinea pigs), 922
Immunosuppression, gallium arsenide-in-duced, reversal, mixed disulfide me-tabolite of meso-2,3-dimercaptosuc-cinic acid (mice), 695
Impicciatore, M., see Morini, G., 598Imura, N., see Tanaka-Kagawa, T., 776Ingelman-Sundberg, M., see Badger, T. M.,
438Ingelman-Sundberg, M., see Ronis, M. J. J.,
944Ingram, H. L., see Breese, C. H., 448Inositol phosphate, formation, Bi and B2
kinin receptors, superior mesentericartery smooth muscle cells (rabbits),930
Inoue, K., see Doi, H., 873Inoue, Y., see Kamei, S., 469Insulin
hepatic metabolism, glyburide and glipi-zide (rats), 1293
70-kilodalton fluorescein-dextran, phar-macokinetics, diabetes mellitus(rats), 662
secretion in islets of Langerhans, energylevel, effect of Ca’� channel blockers(rats), 35
Insulin-like growth factor-i, long-termsuppression, in utero ethanol expo-sure (rats), 448
Interleukin 1�3, repression of drug-metabo-lizing enzymes, arthritis (rats), 1012
Interleukins, morphine-induced suppres-sion, cytokine reversal, antibody re-sponse (mice), 591
Intestineamelioration ofchronic ileitis, nitric oxide
synthase inhibition (rats), iiascending enteric reflex contraction,
propagation of excitation, acetylcho-line and tachykinins (guinea pigs),391
motility, differential effects, antimuscar-inic agents (dogs), 789
muscle cells, histamine H1 and H2 recep-tors, signal transduction pathways(guinea pigs), 598
Inturrisi, C. E., see Tiseo, P. J., 1090Ion transport
jejunum, neuropeptide Y, peptide YY andsigma ligands (mice), 1268
neurally mediated actions of leukotrienes,distal colon (guinea pigs), 384
Ipsapirone, benzodiazepine withdrawal,conflicting evidence regarding effi-cacy, ondansetron (rats), 622
Irby, D., see Badger, T. M., 438, 938Irby, D., see Ronis, M. J. J., 944Ischemia
-induced acute renal failure, kidney en-dothelin receptors (rats), 345
induction of heme oxygenase-1 messengerRNA and protein, kidney (rats), 457
renal vasoconstriction, interaction,thromboxane A2 and angiotensin II(dogs), 1285
Ishida, H., see Fujita, S., 226Ishitani, H., see Sunaga, K., 463Ishizaki, T., see Echizen, H., 1425Isobutylmethylxanthine, forskolin and,
delta opioid receptor activity,NG1O8-i5 cells, 1474
Isoproterenol, r-aminobutyric acid-induceddepression, ethanol effects, cerebellarPurkinje neurons (rats), 951
Iwamoto, K., see Imamura, Y., 166
Jackisch, R., Huang, H. -Y., Reimann, W.and Limberger, N.: Effects of the an-tiparkinsonian drug budipine on neu-rotransmitter release in central nerv-ous system tissue in vitro, 889
Jaconetta, S. M., see Ordway, G. A., 967Jakubovic, A., see Robertson, G. S., 1344Jang, E., see Kostka, P., 234Jarbe, T. U. C., Hiltunen, A. J., Mathis, D.
A., Hanus, L., Breuer, A. and Mech-oulam, R.: Discriminative stimuluseffects and receptor binding of en-antiomeric pairs of cannabinoids inrats and pigeons; a comparison, 561
Javors, M. A., see King, T. S., 29Jejunum, ion transport, neuropeptide Y,
peptide YY and Sigma ligands (mice),1268
Jia, H., Furukawa, T., Singer, D. H., Sak-akibara, Y., Eager, S., Backer, C.,Arentzen, C. and Wasserstrom, J. A.:Characteristics of lidocaine block ofsodium channels in single humanatrial cells, 1275
Jiang, Q., Seyed-Mozaffari, A., Archer, S.and Bidlack, J. M.: Pharmacologicalstudy of i4fl-(thioglycolamido)-7,8-dihydro-N(cyclopropylmethyl)-nor-morph inone (N-CPM-TAMO), 1021
Jin, C., Miners, J. 0., Lillywhite, K. J. andMackenzie, P. I.: Complementary de-oxyribonucleic acid cloning andexpression of a human liver uridinediphosphate-glucuronsyltransferaseglucuronidating carboxylic acid-con-taming drugs, 475
Johnston, P. A. and Kau, S. T.: A micro-puncture study on the renal site ofaction of ICI 206,970, a unique eu-kalemic diuretic, 604
Jolas, T., see Kidd, E. J., 863Jonarchi, N., see Higgins, G. A., 1440Jones, B. E., see Ferkany, J. W., 256Jones, M. V., see Lovinger, D. M., 1097Jouzeau, J.-Y., see Ferrari, L., 1012Jugus, M., see Nambi, P., 345Junien, J. L., see Riviere, P. J. M., 1268Juul, B., Plesner, L. and Aalkjaer, C.: Ef-
fects of ATP and related nucleotides
on the tone of isolated rat mesentericresistance arteries, 1234
Kadowitz, P. J., see Osei, S. Y., 1104Kaechi, K., Furukawa, Y., Igegami, H., Nak-
amura, N., Omae, F., Hashimoto, Y.,Hayashi, K. and Furukawa, S.: Phar-macological induction of physiologi-cally active nerve growth factor in ratperipheral nervous system, 321
Kainate, excitatory amino acid agonists,dipsogenic effects (pigeons), 918
Kakkis, J. L., see Miller, M. J. S., iiKallen, H. G., see Boundy, V. A., 1002
Kalsner, S.: Cocaine sensitization of coro-nary artery contractions: Mechanismof drug-induced spasm, 1132
Kamei, S., Okada, H., Inoue, Y., Yoshioka,T., Ogawa, Y. and Toguchi, H.: An-titumor effects of angiogenesis inhib-itor TNP-470 in rabbits bearing VX-2 carcinoma by arterial administra-tion of microspheres and oil solution,469
Kameyama, T., see Ichihara, K., 122
Kamien, J. B., see Bickel, W. K., 360Kamien, J. B., see Mello, N. K., 530Karasawa, T., see Oka, M., 158Karbon, E. W., see Ferkany, J. W., 256Katayama, K.-I., see Nagakawa, J.-I., 496Kato, H., see Yasumori, T., 89Katz, J. L., Griffiths, J. W., Sharpe, L. G.,
De Souza, E. B. and Witkin, J. M.:Cocaine tolerance and cross-toler-ance, 183
Katz, J. L., see Scanzello, C. H., 1484Kau, S. T., see Johnston, P. A., 604Kawasaki, H., see Echizen, H., 1425Kazusaka, A., see Fujita, S., 226Kelland, M. D., see Pitts, D. K., 616Ketanserin, acute and chronic hypertensive
mechanism (rats), 129a-Ketoisocaproate, energy level and stimu-
lated insulin secretion, Ca�� channelblockers, islets of Langerhans (rats),35
Khansa, M. H., see Wolf, M. E., 249Kidd, E. J., Haj-Dahmane, S., Jolas, T.,
Lanfumey, L., Fattaccini, C.-M.,Guardiola-Lemaitre, B., Gozlan, H.and Hamon, M.: New methoxy-chro-man derivatives, 4[N-(5-methoxy-chroman-3-yl)N-propylaminojbutyl-8-azaspiro-(4,5)- decane-7,9-dione[(±)-520244] and its enantiomers,
(+)-S 20499 and (-)-S 20500, withpotent agonist properties at central5-hydroxytryptamine1. receptors, 863
Kidneyautoradiographic localization, dopamine
D1 receptors (humans), 431connecting tubules of nephron, coupling
of beta-i and beta-2 adrenoceptors(rabbits), 105
dopamine synthesis, diuretic effect of fu-rosemide (rats), 1377
endothelin receptors, ischemia-inducedacute renal failure (rats), 345
heme oxygenase-i messenger RNA andprotein, induction by ischemia/reper-fusion (rats), 457
hormonal regulation of acetohexamide re-ductase, postnatal development, sex-related differences (rats), 166
inner medullary collecting duct cells, a!-
1502 Index Vol. 264
pha-2 adrenergic receptors (rabbits),879
micropuncture study, action of ICI 206,970 (rats), 604
microvascular actions of YM435 (rats),1154
postischemic vasoconstriction, interac-tion, thromboxane A2 and angioten-sin II (dogs), 1285
synthesis of dopamine, role of sodium(rats), 406
testosterone modulation of N-acetylation(mice), 854
tubular secretion and reabsorption, mer-cury compounds (mice), 776
King, T. S., Canez, M. S., Gaskill, S., Javors,M. A. and Schenken, H. S.: Chroniccocaine disruption of estrous cyclicityin the rat: Dose-dependent effects, 29
Kishel, M. T., see Pettibone, D. J., 308Koek, W., Colpaert, F. C. and Vignon, J.:
Effects of phencyclidine-type drugsin rats discriminating fentanyl from
saline: Pharmacological and behav-ioral characterization of intermediatelevels of drug lever selection, 746
Koob, G. F., see Negus, S. S., 739Kostka, P., Jang, E., Watson, E. G., Stewart,
J. L. and Daniel, E. E.: Nitric oxidesynthase in the autonomic nervoussystem of canine lleum, 234
Krecic, M. E., see Apseloff G., 1071Kroboth, P. D., Bertz, R. J. and Smith, H.
B.: Acute tolerance to triazolam dur-ing continuous and step infusions:Estimation of the effect offset rateconstant, 1047
Ku, D. D., see Winn, M. J., 265Kucharczyk, N., see McCabe, H. T., 1248Kuemmerle, J. F., see Morini, G., 598Kuenzli, K. A., see Bradley, M. E., 1033Kuhn, H., see Roux, S. P., 501Kuoppam#{228}ki, M., Sepp#{228}la,T., Syv#{228}lahti,E.
and Hietala, J.: Chronic clozapinetreatment decreases 5-hydroxytryptamine1c receptor den-sity in the rat choroid plexus: Com-parison with haloperidol, 1262
Kurumiya, S., see Oka, M., 158Kusano, E., see Homma, S., 105Kuster, J. E., Stevenson, J. I., Ward, S. J.,
D’Ambra, T. E. and Haycock, D. A.:
Aminoalkylindole binding in rat cer-ebellum: Selective displacement bynatural and synthetic cannabinoids,1352
Kwan, C.-Y., see Shimamoto, Y. :201
L 659,877, initiation of micturition reflex,peripheral role, tachykinins (rats),1327
Lai, H., see Prather, P. L., 622Landaw, E. M., see Cho, A. K., 1401Lane, J. D., see Prather, P. L., 622Lane, W. V., see Xie, Y., 689Lanfumey, L., see Kidd, E. J., 863Laniyonu, A., see Yang, S.-G., 958
Law, P. Y., see Bergsbaken, C. L., 1474Lawson, J. A., see DeGraff, G. L., 6Lead, inhibition of brain protein kinase C
subtypes (rats), 757Learning
latent, impairment by dopaminergic ago-nists (mice), 122
performance and subject ratings, acute
effects, triazolam and lorazepam (hu-mans), 1218
Lecchini, S., see de Ponti, F., 789Lecci, A., Giuliani, S., Patacchini, H. and
Maggi, C. A.: Evidence against a pe-ripheral role of tachykinins in theinitiation of micturition reflex inrats, 1327
Lee, H. S., see Balasubramaniam, G., 129Leeb-Lundberg, L. M. F., see Tropea, M.
M., 930Lehnert, S., see Alaoui-Jamali, M. A., 1299leMarouille-Girardon, S., see Millan, M. J.,
1364Lenham, J., see Breese, C. H., 448Leukocytes, amelioration of chronic ileitis,
nitric oxide synthase inhibition(rats), ii
Leukotrienesinflammatory mediators, electrolyte
transport, distal colon epithelium(pigs),61
neurally mediated actions, ion transport,distal colon (guinea pigs), 384
Levant, B., Grigoriadis, D. E. and DeSouza,E. B.: [3H]Quinpirole binding to pu-tative D2 and D3 dopamine receptorsin rat brain and pituitary gland: Aquantitative autoradiographic study,991
Levin, G., see Nowicki, S., 1377Levine, J. D., see Miao, F. J.-P., 839Levitin, M., see Lovinger, D. M., 1097Levy, G., see Hoffman, A., 859Li, Z. and Duckles, S. P.: Acute effects of
nicotine on rat mesenteric vascula-
ture and tail artery, 1305
Lidocaine, block of sodium channels, singleatrial cells (humans), 1275
Liewer, S. A., see Toews, M. L., 1211Ligands
-y-hydroxybutyrate, antidopaminergic
and neuroleptic-like activities, 1406sigma, neuropeptide Y and peptide YY,
ion transport in jejunum (mice), 1268Liljequist, S. and Tabakoff, B.: Bicuculline-
produced regional differences in themodulation of �S-TBPS binding byGABA, pentobarbital, and diazepamin mouse cerebellum and cortex, 638
Lillywhite, K. J., see Jin, C., 475Limberger, N., see Jackisch, H., 889Lin, A. M.-Y., Bickford, P. C. and Palmer,
M. H.: The effects of ethanol on r-
aminobutyric acid-induced depres-sions of cerebellar Purkinje neurons:Influence of beta adrenergic receptoraction in young and aged Fischer 344rats, 951
Lipid peroxidation, tert-butylhydroperox-ide-induced inhibition, endothelialcell calcium signaling (calves), 1063
Lipopolysaccharide, protective effect ofE3330, galactosamine-induced hepa-titis (rats), 496
5-Lipoxygenase, influence of epithelium,histamine release and contraction,tracheal strips (guinea pigs), 717
Lis, E. V., see Pettibone, D. J. , 308Liu, E. C. K., see Webb, M. L., 1387Liu, Z., Brien, J. F., Marks, G. S., Mc-
Laughlin, B. E. and Nakatsu, K.:Lack of evidence for the involvementof cytochrome P-450 or other hemo-proteins in metabolic activation of
glyceryl trinitrate in rabbit aorta,1432
Liveralteration of insulin metabolism, glybur-
ide and glipizide (rats), 1293cytochrome P450 isozymes, chronic
ethanol, growth hormone secretion(rats),438
hormonal regulation of acetohexamide re-ductase, postnatal development, sex-related differences (rats), 166
induction of cytochrome P450 2E1, pyra-zole and 4-methylpyrazole, neonates(rats),1468
regio- and stereoselective propranolol me-tabolism, 15 forms of cytochromesP450 (rats), 226
UDP-glucuronosyltransferase glucuroni-dating carboxylic acid-containing
drugs, complementary DNA cloningand expression (humans), 475
Liver microsomes, mono-N-dealkylationmetabolism of disopyramide, potentinhibitory effect, erythromycin andother macrolide antibiotics (hu-mans), 1425
Locus coeruleus, a!pha-2 adrenoceptor sub-types (humans), 967
Loeffler, H. F., see Gullikson, G. W., 240Lombardy, H. J., see Caughey, G. H., 676Long, J. B., see Dosaka-Akita, K., 631Lopaschuk, G. D., Wambolt, R B. and Barr,
H. L.: An imbalance between glycol-
ysis and glucose oxidation is a possi-ble explanation for the detrimentaleffects of high levels of fatty acidsduring aerobic reperfusion of is-chemic hearts, 135
Lorazepam, triazolam and, acute effects,learning and performance (humans),1218
Loring, H. H., see Xie, Y., 689Losartan, hormonal and cardiovascular ef-
fects (monkeys), 6Lovinger, D. M., Zimmerman, S. A., Levitin,
M., Jones, M. V. and Harrison, N. L.:Trichloroethanol potentiates synap-tic transmission mediated by -y-ami-
nobutyric acidA receptors in hippo-campal neurons, 1097
Lowensohn, H. I., see Pettibone, D.J., 308Luck, M. S. and Bass, P.: Effect of epider-
mal growth factor on experimentalcolitis in the rat, 984
Luedtke, H. H., see Boundy, V. A., 1002Lukas, S. E., see Mello, N. K., 530Lumpkin, C. K., see Badger, T. M., 438Lumpkin, C. K., see Ronis, M. J. J., 944Lundin, S., Broeders, A., Ohlin, M., Hans-
son, K., Bengtsson, H.-I., Trojnar, J.and Melin, P.: Pharmacokinetic andpharmacologic properties of antiuter-otonic oxytocin analogs in the rat,783
Lungantiallergic and bronchodilator effects,
isozyme-selective phosphodiesteraseinhibitors (guinea pigs), 609
eosinophilia, antigens, IgG1 sensitization(guinea pigs), 922
vascular bed, tone-dependent responses ofserotonin, different 5-HT receptors(cats), 1315
Lupus nephritis, glomerular thromboxanereceptors (mice), 584
1993 Index 1503
Luteinizing hormone, secretion in prepu-bescence, failure to reverse inhibitoryeffect of morphine, naloxone (rats),47
LY274614, attenuation and reversal, mor-phine tolerance (rats), 1090
Lytle, D. A., see Prather, P. L., 622
Mackenzie, P. I., see Jin, C., 475Macrolides, erythromycin and others, po-
tent inhibitory effect, mono-N-deal-kylation metabolism of disopyramide(humans), 1425
Macromolecules, 70-kilodalton fluorescein-dextran, pharmacokinetics, diabetes
mellitus (rats), 662Macrophages, morphine-induced suppres-
sion, cytokine reversal, antibody re-sponse (mice), 591
Maggi, C. A., see Holzer, P., 391Maggi, C. A., see Lecci A., 1327Maggi, C. A., see Patacchini, H., 17Mah, S. C., see Balasubramaniam, G., 129Manes, M. D., Mayer, H. D., Ewing, J. F.
and McCoubrey, W. K., Jr.: Induc-tion of kidney heme oxygenase-1(HSP32) mRNA and protein by is-chemia/reperfusion: Possible role ofheme as both promotor oftissue dam-age and regulator of HSP32, 457
Maitre, M., see Hechler, V., 1406Maixner, W., see Suarez-Roca, H., 648Makhlouf, G. M., see Morini, G., 598Manning, C. D., see Barnette, M. S., 801Maren, T. H., see Brechue, W. F., 670Mark, J., see Hechler, V., 1406Marks, G. S., see Liu, Z., 1432Marks, M. J., Farnham, D. A., Grady, S. H.
and Collins, A. C.: Nicotinic receptorfunction determined by stimulationof rubidium efflux from mouse brainsynaptosomes, 542
Martello, A. L., see Scanzello, C. H., 1484Martin, I., see Miralles, A., 1187Mast cells, tryptases, reversible inhibitors,
bis(5-amidino-2-benzimidazo-lyl)methane and related amidines(dogs), 676
Masuda, M., see Fujita, S., 226Mathis, D. A., see J#{228}rbe,T. U. C., 561Matot, I., see Neely, C. F., 1315Maxwell, D. M., Brecht, K. M., Doctor, B.
P. and Wolfe, A. D.: Comparison ofantidote protection against soman bypyridostigmine, Hl-6 and acetylcho-linesterase, 1085
Mayer, H. D., see Manes, M. D., 457McCabe, R T., Wasterlain, C. G., Kuchar-
czyk, N., Sofia, H. D. and Vogel, J.R.: Evidence for anticonvulsant andneuroprotectant action of felbamatemediated by strychnine-insensitiveglycine receptors, 1248
McCoubrey, W. K., Jr., see Manes, M. D.,457
McDonald, D. M., see Petersson, G., 509McKelvy, J. F., see Firestone, J. A., 1206Mckinney, M., Miller, J. H. and Aagaard,
P. J.: Pharmacological characteriza-tion of the rat hippocampal musca-rinic autoreceptor, 74
McLaughlin, B. E., see Liu, Z., 1432MDL 72832, MDL 73005 EF and, induction
ofhypothermia, 5-HT1A receptor-me-diated activity (rats), 1364
Mechoulam, H., see J#{225}rbe,T. U. C., 561
Meclofenamate, adenosine-stimulated con-traction, lack of cyclo-oxygenase in-volvement, nonpregnant myomet-rium (guinea pigs), 1033
Meglasson, M. D., see Ohta, M., 35Mehta, M., see Gallo, J. M., 315Mehvar, H. and Reynolds, J. M.: Pharma-
cokinetics of 70-kilodalton fluores-cein-dextran in experimental diabe-tes mellitus, 662
Melin, P., see Lundin, S., 783Mello, N. K., Kamien, J. B., Lukas, S. E.,
Mendelson, J. H., Drieze, J. M. andSholar, J. W.: Effects of intermittentbuprenorphine administration on co-caine self-administration by rhesusmonkeys, 530
Memory, short-term, delayed match to sam-ple performance, 6-9-tetrahydrocan-nabinol (rats), 294
Mendelson, J. H., see Mello, N. K., 530Mephenytoin, stereoselective metabolism of
cytochrome P450, species differences(rats, rabbits, dogs, monkeys, hu-mans), 89
Mercado, C., see Badger, T. M., 438Mercado, C., see Ronis, M. J. J., 9446-Mercaptopurine, S-(6-puri-
nyl)glutathione and, mechanisms of
formation, 6-chloropurine (rats), 41Mercury compounds, metallothionein and,
tubular secretion and reabsorption,kidney (mice), 776
Methacholinealteration in modulatory role, respiratory
epithelium, exposure to cotton dust(guinea pigs), 683
contractile effects of nucleotides, trachea(guinea pigs), 210
relaxant effects of nucleotides, trachea(guinea pigs), 217
Methamphetamine, impairment of latentlearning (mice), 122
Methoxy-chroman derivatives, agonistproperties, central 5-HT1A receptors(rats), 863
N-Methyl-D-aspartate
antagonists, discriminative stimulus ef-fects, ethanol (rats), 1241
-evoked release from cortical slices, cho-linergic modulation (rats), 282
excitatory amino acid agonists, dipsogeniceffects (pigeons), 918
receptor antagonist, dopamine D1 and D2agonist interactions, i-methyl-4-phenyl-1,2,5,6-tetrahydropyridineinduction (monkeys), 221
Methyl chloroform, 1,1,1-trichloroethane-produced physical dependence, ef-fects of drugs and vapors, withdrawal(mice), 726
3,4-Methylenedioxymethamphetamine, in-jury, serotonergic recovery (rats),1484
1-Methyl-4-phenyl-1,2,5,6-tetrahydropyri-
dine, induction, NMDA receptor an-tagonist, dopamine D1 and D2 agonistinteractions (monkeys), 221
4-Methylpyrazole, pyrazole and, inductionof liver cytochrome P450 2E1, neo-nates (rats), 1468
5-Methyltryptamine, tracheal contractileserotonergic receptor, 5-HT2 receptor(guinea pigs), 271
Methysergide, rauwolscine, contraction in
mesenteric artery, precontractionwith KC1 and endothelin-1 (dogs),201
Mexiletine, interaction of sodium and po-tassium channel blockers, papillarymuscle (guinea pigs), 1056
Miao, F. J.-P., Dallman, M. F., Benowitz,N. L., Basbaum, A. I. and Levine, J.D.: Adrenal medullary modulation ofthe inhibition of bradykinin-inducedplasma extravasation by intrathecalnicotine, 839
Microvasculature, renal, actions of YM435(rats), 1154
Micturition reflex, initiation of, peripheralrole, tachykinins (rats), 1327
Midazolam, i,1,i-trichloroethane-producedphysical dependence, effects of drugsand vapors, withdrawal (mice), 726
Mignot, B., see Nishino, S., 1079Migrating myoelectric complex, intestinal
motility, differential effects, anti-muscarinic agents (dogs), 789
Millan, M. J., Rivet, J.-M., Canton, H.,leMarouille-Girardon, S. and Gobert,A.: Induction of hypothermia as amodel of 5-hydroxytryptaminelA re-ceptor-mediated activity in the rat: Apharmacological characterization ofthe actions of novel agonists and an-tagonists,1364
Millan, M. J., see Bervoets, K., 95Miller, J. H., see Mckinney, M., 74Miller, M. J. S., Sadowska-Krowicka, H.,
Chotinaruemol, S., Kakkis, J. L. andClark, D. A.: Amelioration of chronicIleitis by nitric oxide synthase inhi-bition, ii
Miller, H. J., see Rhim, H., 795
Miners, J. 0., see Jin, C., 475Minkes, H. K., see Osei, S. Y., 1104
Miralles, A., Olmos, G., Sastre, M., Barth-ren, F., Martin I. and Garcia-Sevilla,J. A.: Discrimination and pharmaco-logical characterization of 12-imida-zoline sites with [3Hlldazoxan andalpha-2 adrenoceptors with [3H]RX821002 (2-methoxy idazoxan) inthe human and rat brains, 1187
Miramatsu, M., see Cho, A. K., 1401Misra, H. N., see Ogletree, M. L., 570Misra, H. N., see Webb, M. L., 1387Miyamoto, K., see Nagakawa, J.-I., 496Miyamoto, Y., Portoghese, P. 5. and Take-
mori, A. E.: Involvement of Delta2opioid receptors in the developmentof morphine dependence in mice,1141
MK8O1attenuation and reversal of morphine tol-
erance, LY274614 (rats), 1090
1-methyl-4-phenyl-1,2,5,6-tetrahydropyr-idine induction, NMDA receptor an-tagonist, dopamine D1 and D2 agonistinteractions (monkeys), 221
Moghaddam, B., see Youngren, K. D., 289Molinoff, P. B., see Boundy, V. A., 1002NG�Monomethyl�L�arginine, Nw nitro L-ar-
ginine methyl ester and, vasomotorresponses, coronary arterial rings(dogs), 265
Monshizadegan, H., see Webb, M. L., 1387Moore, B. W., see Nock, B., 349Morini, G., Kuemmerle, J. F., Impicciatore,
M., Grider, J. H. and Makhlouf, G.
1504 Index Vol. 264
M.: Coexistence of histamine H1 andH2 receptors coupled to distinct sig-nal transduction pathways in isolatedintestinal muscle cells, 598
Morita, H., see Ueki, S., 152Morphine
attenuation and reversal of tolerance,LY274614 (rats), 1090
brief exposure, withdrawal responses inileum, effects of NSAIDs (guineapigs), 1028
development of dependence, involvement,delta-2 opioid receptors (mice), 1141
failure to reverse inhibitory effect, nalox-one, luteinizing hormone secretion inprepubescence (rats), 47
-induced suppressioncytokine reversal, antibody response
(mice), 591splenocyte natural killer activity, aipha
adrenergic and mu-2 opioid recep-tors, 1179
U-50,488H and, activation ofkappa opioidreceptors, substance P release (rats),648
Morrone, L. A., see Valeri, P., 1028Mosberg, H. I., see Wild, K. D., 831Moummi, C., see Gullikson, G. W., 240Mounier, C., Hatmi, M., Faili, A., Bon, C.
and Vargaftig, B. B.: Competitive in-hibition of phospholipase A2 activityby the platelet-activating factor an-tagonist Ho 19-3704 and evidence fora novel suppressive effect on plateletactivation, 1460
Moxonidine, selective ligand for 11-imida-zoline sites (cattle), 172
Mr2033, respiratory depressant effects, ap-parent pA2 analysis (monkeys), 145
Mucosa, nasal, neurogenic plasma extrava-sation, peptidase inhibitors (rats),509
Munson, A. E., see Burns, L. A., 695Murakami, K., Feng, G. and Chen, S. G.:
Inhibition of brain protein kinase Csubtypes by lead, 757
Murayama, N., see Homma, S., 105Murray, T. F., see Zhang, G., 1415Muscle
papillary, interaction, sodium and potas-sium channel blockers (guinea pigs),1056
retardation of atrophy, aminohydroxybu-tane bisphosphonate and clenbuterol,tail-suspended rats, 1071
rigidity, alfentanil-induced antinocicep-tion, fl-funaltrexamine and naloxon-azine (rats), 739
Muscle, smoothantiuterotonic oxytocin analogs, phar-
macokinetic and pharmacologicproperties (rats), 783
colonic, cyclic nucleotide phosphodiester-ase isozymes (dogs), 801
gastric, distinct signal transduction path-ways, angiotensin II (guinea pigs),958
intestine, histamine H1 and H2 receptors,signal transduction pathways (guineapigs), 598
mesenteric vasculature, acute effects ofnicotine, tail artery (rats), 1305
superior mesenteric artery, Bi and B2kinin receptors (rabbits), 930
vascular, serotonin-induced contraction,coronary artery (pigs), 193
Myeloperoxidase, epidermal growth factor,experimental colitis (rats), 984
Myocardial ischemia, protection from in-jury, stimulation of endogenous pros-tacyclin (pigs), 397
Myocytesatrial, potassium channel blocking prop-
erties, propafenone (rabbits), 1113cardiac, alterations of calcium dynamics,
U46619 (rats), 336ventricular
4-aminopyridine block, transient out-ward K� current (rats), 1450
two delayed rectifiers, tail current ki-netics (guinea pigs), 553
Myometrium, nonpregnant, adenosine-stimulated contraction, lack of cyclo-oxygenase involvement (guinea pigs),1033
Nabeshima, T., see Ichihara, K., 122Na�-Ca�� exchanger, inhibition enhances
anoxia and glucopenia-induced as-partate release, hippocampal slices(rats), 515
Nadel, J. A., see Petersson, G., 509
Nagakawa, J.-I., Hirota, K., Hishinuma, I.,Miyamoto, K., Sonoda, J., Yaman-aka, T., Katayama, K-I. and Ya-matsu, I.: Protective effect of E3330,a novel quinone derivative, in galac-tosamine-induced hepatitis in rats,496
Naganuma, A., see Tanaka-Kagawa, T., 776Nagata, K., see Yasumori, T., 89Nakamura, N., see Kaechi, K., 321Nakane, T. and Chiba, S.: Pharmacological
analysis of vasodilation induced byextracellular adenosine 3 ‘ ,5 ‘ -cyclicmonophosphate in the isolated andperfused canine coronary artery,1253
Nakatsu, K., see Liu, Z., 1432Naloxonazine, $-funaltrexamine and, alfen-
tanil-induced antinociception, mus-cle rigidity (rats), 739
Naloxonedevelopment of morphine dependence, in-
volvement, delta-2 opioid receptors(mice), 1141
failure to reverse inhibitory effect of mor-phine, luteinizing hormone secretion,prepubescence (rats), 47
-resistant receptors for fl-endorphin, pro-tein kinase C activation, U937 cells,276
Naltrexone, differential antagonism, hydro-morphone and pentazocine effects(humans), 813
Naltriben, development of morphine de-pendence, involvement, delta-2opioid receptors (mice), 1141
Nambi, P., Pullen, M., Jugus, M. and Gellai,M.: Rat kidney endothelin receptorsin ischemia-induced acute renal fail-ure, 345
Narahashi, T., see Heuveny, E., 22Narcolepsy, control of cataplexy, aipha-i
receptor subtype (dogs), 1079Nassar, H., see Wolf, M. E., 249Nattel, S., see Duan, D., 1113Nattel,S.,seeRanger,S., 1160Natural killer cells, splenocyte activity,
morphine-induced suppression, alpha
adrenergic and mu-2 opioid recep-tors, 1179
Neely, C. F., Haile, D. and Matot, I.: Tone-dependent responses of 5-hydroxy-tryptamine in the feline pulmonaryvascular bed are mediated by two dif-ferent 5-hydroxytryptamine recep-tors, 1315
Negus, S. S., Pasternak, G. W., Koob, G. F.and Weinger, M. B.: Antagonist ef-fects of fl-funaltrexamine and nalox-onazine on alfentanil-induced antin-ociception and muscle rigidity in therat, 739
Nelson, D., see Ohta, M., 35Nelson, J., see Ohta, M., 35Neostigmine, survival during hypoxia, gen-
der differences (mice), 1146Nephron, connecting tubules, coupling of
beta-i and beta-2 adrenoceptors,cyclic AMP system (rabbits), 105
Nereistoxin, redox effects, neuronal nico-tinic acetylcholine receptors, retina(chicks), 689
Nervecholinergic and noncholinergic, mu and
alpha-2 receptors (guinea pigs), 375phrenic, diaphragm, effect of arachidonic
acid on twitch tension (rats), 1311renal, antinatriuresis, suppression by
TMB-8 (dogs), 117Nerve growth factor, physiologically active,
pharmacological induction, periph-eral nervous system (rats), 321
Netter, P., see Ferrari, L., 1012Neuroblastoma, desensitization and down-
regulation, neurotensin(8-13), neu-rotensin receptors (mice), 1
Neuroblastoma cellsblock of two types of calcium channels,
chlordiazepoxide (mice), 22chronic etorphine-induced sensitization,
adenylyl cyclase, buprenorphine pre-vention and reversal, 368
Neurokinin, peripheral role of tachykinins,initiation, micturition reflex (rats),
1327Neurokinin A
derivatives and agonist and antagonistproperties, biological activity, C-ter-minal amidation (guinea pigs, rab-bits, hamsters, rats), 17
tachykinins and acetylcholine, ascendingenteric reflex contraction (guineapigs),391
Neurones, serotonergic, 5-HT1A receptors,tail-flick response (rats), 95
Neuronscerebellar Purkinje, ethanol effects, r-
aminobutyric acid-induced depres-sion (rats), 951
dopamine, electrophysiological effects, di-phenylpyrazolidinone cholecystoki-nm-B and -A antagonists (rats), 480
hippocampal, trichloroethanol-poten-tiated synaptic transmission, media-tion by GABAA receptors, 1097
nigrostriatal, role of forebrain, repeatedamphetamine administration (rats),616
pharmacological induction, physiologi-cally active nerve growth factor(rats), 321
serotonergic recovery, 3,4-methylene-
1993 Index 1505
(rats),1484Neuropeptide Y, peptide YY and sigma li-
gands, ion transport, jejunum (mice),
1268Neurotensin, desensitization and down-reg-
ulation, neurotensin receptors, N1E-115 cells (mice), 1
Neurotoxicity, theophylline, adrenalectomy,kinetics of drug action in diseasestates (rats), 859
Neurotransmissionatrial natriuretic factor, guanylate cy-
clase-coupled receptors, vas deferens(rabbits), 1227
norepinephrine uptake and release, ac-tions of A-7500, bovine adrenal chro-maffin cells, 1206
NeurotransmitterNMDA-evoked norepinephrine release,
cholinergic modulation, corticalslices (rats), 282
release, budipine effects, central nervoussystem tissue (rabbits), 889
Neutrophils, stimulation of endogenousprostacyclin, protection from injury,myocardium (pigs), 397
NG1O8-i5 cells, delta opioid receptor activ-ity, forskolin and isobutylmethylxan-thine, 1474
Nicotineacute effects, mesenteric vasculature, tail
artery (rats), 1305intrathecal, adrenal medullary modula-
tion, bradykinin-induced plasma ex-travasation (rats), 839
Nifedipinecocaine sensitization of coronary artery
contractions, mechanism, drug-in-duced spasm (cattle), 1132
energy level and stimulated insulin secre-
tion, islets of Langerhans (rats), 35renal nerve stimulation-induced antina-
triuresis, suppression by TMB-8(dogs), 117
Nimodipine, zidovudine kinetics (monkeys),315
Nirei, H., see Sogabe, K., 1040Nishino, S., Fruhstorfer B., Arrigoni, J.,
Guilleminault, C., Dement, W. C. andMignot, E.: Further characterizationof alpha-i receptor subtype involvedin the control of cataplexy in caninenarcolepsy, 1079
Nitric oxide synthaseautonomic nervous system of ileum
(dogs), 234
inhibition, amelioration, chronic ileitis(rats), 11
Nw Nitro L-arginine methyl ester, NG�mon�omethyl-L-arginine and, vasomotorresponses, coronary arterial rings(dogs), 265
Nizatidine, gastroprokinetic activity (dogs,rats), 152
Nock, B., Giordano, A. L., Moore, B. W.and Cicero, T. J.: Properties of theputative epsilon opiod receptor: Iden-tification in rat, guinea pig, cow, pigand chicken brain, 349
Nock, B., see Cicero, T. J., 47Noda, Y., see Oka, M., 158Nomifensine, impairment of latent learning
(mice), 122
Nomoto, A., see Sogabe, K., 1040
injury Noradrenalinebudipine effects, neurotransmitter re-
lease, central nervous system tissue(rabbits), 889
inhibition of release from stomach, cho-linergic M2 muscarinic receptors(rats), 54
Norepinephrineneurally mediated action of leukotrienes,
ion transport, distal colon (guinea
pigs), 384
NMDA-evoked release, cholinergic mod-ulation, cortical slices (rats), 282
release in paraventricular nucleus/ante-nor hypothalamus, histamine (rats),734
uptake and release, actions of A-75200,bovine adrenal chromaffin cells, 1206
Notsu, V., see Sogabe, K., 1040Novy, M. J., see Pettibone, D. J., 308Nowicki, S., Levin, G. and Enero, M. A.:
Involvement of renal dopamine syn-thesis in the diuretic effect of furo-semide in normohydrated rats, 1377
NPC 17742, pharmacological profile (rats,mice, gerbils), 256
NSAIDs, withdrawal responses in ileum,brief exposure to morphine (guineapigs), 1028
Nucleosides, nimodipine effect, zidovudinekinetics (monkeys), 315
Nucleotidesadenosine triphosphate and, tone, mes-
enteric resistance arteries (rats),1234
contractile effects, trachea (guinea pigs),210
modulation of low affinity binding sites,glibenclamide, brain (rats), 701
relaxant effects, trachea (guinea pigs), 217Nucleotides, cyclic, phosphodiesterase iso-
zymes, colonic smooth muscle (dogs),801
Nucleus accumbensautoreceptor subsensitivity, enhanced do-
pamine release, amphetamine sensi-tization (rats), 249
outflow of dopamine, distinct actions, en-dogenous excitatory amino acids(rats), 289
Nucleus tractus solitarius, modulation of af-ferent transmission, selective opioidagonists (rats), 795
Ochi, Y., see Oka, M., 158
O’Connor, L., see Cicero, T. J, 47O’Donnell, J. M.: Antidepressant-like ef-
fects of rolipram and other inhibitorsof cyclic adenosine monophosphatephosphodiesterase on behavior main-tamed by differential reinforcementof low response rate, 1168
Ogasawara, A., Hisa, H. and Satoh, S.: Anintracellular calcium release inhibi-tor TMB-8 suppresses renal nervestimulation-induced antinatriuresisin dogs, 117
Ogawa, Y., see Kamei, S., 469Ogletree, M. L., Harris, D. N., Schumacher,
W. A., Webb, M. L. and Misra, H. N.:Pharmacological profile of BMS 180,
291: A potent, long-acting, orally ac-tive thromboxane A2/prostaglandinendoperoxide receptor antagonist,570
O’Grady, S. M., see Traynor, T. H., 61
8-OH-DPAT5-HT1A receptors and tail-flick response
(rats), 95induction of hypothermia, 5-HT,A recep-
tor-mediated activity (rats), 1364
Ohlin, M., see Lundin, S., 783
Ohta, M., Nelson, J., Nelson, D., Meglasson,M. D. and Ereci#{241}ska, M.: Effect ofCa� channel blockers on energy leveland stimulated insulin secretion inisolated rat islets of langerhans, 35
Oka, M., Noda, Y., Ochi, Y., Furukawa, K.,Une, T., Kurumiya, S., Hino, K. andKarasawa, T.: Pharmacological pro-file ofAD-5423, a novel antipsychoticwith both potent dopamine-D2 andsenotonin-S2 antagonist properties,
158
Okada, H., see Kamei, S., 469Oliveto, A. H., see Bickel, W. K., 360Olmos, G., see Miralles, A., 1187Omae, F., see Kaechi, K., 321Ondansetron, conflicting evidence regarding
efficacy, benzodiazepine withdrawal(rats),622
Ono, T., see Sogabe, K., 1040Onorato, J. J., see Spurney, H. F., 584
Opiates, failure to reverse inhibitory effectof morphine, naloxone, luteinizinghormone secretion in prepubescence(rats), 47
Opioidsagonists, modulation of afferent transmis-
sion, nucleus tractus solitarius (rats),795
differential naltrexone antagonism, hy-dromorphone and pentazocine effects(humans), 813
intermittent buprenorphine administra-tion, cocaine self-administration(monkeys), 530
morphine-induced suppression, cytokinereversal, antibody response (mice),591
motivational sites, neuroanatomical sites,conditioned place preference para-
digm (rats), 489
mu and a!pha-2 receptors, enteric nerves(guinea pigs), 375
properties of epsilon opioid receptor, brain(rats, guinea pigs, cows, pigs, chick-ens), 349
respiratory depressant effects, apparentpA2 analysis (monkeys), 145
Ordway, G. A., Jaconetta, S. M. and Halanis,
A. E.: Characterization of subtypes ofalpha-2 adrenoceptors in the humanbrain, 967
Organophosphorus compounds, comparisonof antidote protection against soman,pyridostigmine, HI-6 and acetylcho-
linesterase, 1085
Osei, S. Y., Minkes, H. K., Bellan, J. A. andKadowitz, P. J.: Analysis of the in-hibitory effects of DuP 753 and EXP3174 on responses to angiotensin IIin the feline hindquarters vascularbed, 1104
Osumi, Y., see Yokotani, K., 54Otagiri, M., see Imamura, Y., 166Ouabain, synthesis of dopamine in kidney,
role of sodium (rats), 406Ovalbumin, histamine release and contrac-
tion, influence ofepithelium, trachealstrips (guinea pigs), 717
1506 Index Vol. 264
Ovulation, chronic cocaine disruption, es-trous cyclicity, dose-dependent ef-fects (rats), 29
Oxime, comparison of antidote protectionagainst soman, pyridostigmine, HI-6and acetylcholinesterase, 1085
Oxytocin, orally active nonpeptidyl, antag-onist (rats), 308
Oxytocin analogs, antiuterotonic, pharma-cokinetic and pharmacologic proper-ties (rats), 783
Pain5-HT1A receptors and tail-flick response
(rats), 95sensitivity, adrenalectomy, kinetics of
drug action in disease states (rats),
859
Palmer, M. H., see Lin, A. M.-Y., 951Pals, D. T., see DeGraff, G. L., 6Pancreas
acini, exocytotic function, FK506 char-acterization and effects (rats), 873
islets of Langerhans, Ca� channel block-ers, energy level and stimulated in-sulin secretion (rats), 35
Parathyroid hormone, calcemic hormone-and growth factor-based bone resorp-tion, suramin as inhibitor (mice), 579
Parkinson’s disease1-methyl-4-phenyl-1,2,5,6-tetrahydropyr-
idine induction, NMDA receptor an-tagonist, dopamine D1 and D2 agonistinteractions (monkeys), 221
neurotransmitter release, budipine ef-fects, central nervous system tissue
(rabbits), 889Pascaud, X., see Hiviere, P. J. M., 1268Pasternak, G. W., see Negus, S. S., 739Patacchini, H., Quartara, L., Rovero, P.,
Goso, C. and Maggi, C. A.: Role of c-terminal amidation on the biologicalactivity of neurokinin a derivativeswith agonist and antagonist proper-ties,, 17
Patacchini, H., see Lecci A., 1327Patch, H. J., see Ferkany, J. W., 256Patch-clamp
block of two types of calcium channels,chlordiazepoxide, neuroblastomacells (mice), 22
two delayed rectifiers, ventricular myo-cytes, tail current kinetics (guineapigs), 553
Paul, D., see Carr, D. J. J., 1179Pentamidine, bis(5-amidino-2-benzimida-
zolyl)methane, reversible inhibitors,mast cell tryptases (dogs), 676
Pentazocine, hydromorphone and, differ-ential naltrexone antagonism (hu-mans), 813
Pentobarbital, modulation of �S-TBPSbinding, bicuculline-produced re-gional differences, cerebellum andcortex (mice), 638
Pentylenetetrazole, benzodiazepine with-drawal, conflicting evidence regard-ing efficacy, ondansetron (rats), 622
Peptidase, inhibitors, neurogenic plasma ex-travasation, nasal mucosa (rats), 509
Peptide YY, neuropeptide Y and sigma li-gands, ion transport, jejunum (mice),1268
Peptidoleukotrienes, histamine release andcontraction, influence of epithelium,tracheal strips (guinea pigs), 717
Peripheral nervous system, pharmacologicalinduction, physiologically activenerve growth factor (rats), 321
Pertussis toxin, inhibition of noradrenalinerelease from stomach, cholinergic M2muscarinic receptors (rats), 54
Pestana, M., see Soares-[da]-Silva, P., 406Peter, P., see Hechler, V., 1406Peterlik, M., see Farsoudi, K. H., 579Petersson, G., Bacci, E., McDonald, D. M.
and Nadel, J. A.: Neurogenic plasmaextravasation in the rat nasal mucosais potentiated by peptidase inhibi-tors, 509
Pettibone, D. J., Clineschmidt, B. V.,Kishel, M. T., Lis, E. V. Reiss, D. H.,Woyden, C. J., Evans, B. E., Freidin-ger, H. M., Veber, D. F., Cook, M. J.,Haluska, G. J., Novy, M. J. and Low-ensohn, H. I.: Identification of an or-ally active, nonpeptidyl oxytocin an-tagonist, 308
Phencyclidineattenuation and reversal of morphine tol-
erance, LY274614 (rats), 1090-type drugs, discrimination of fentanyl
from saline (rats), 746Phencyclidine hydrochloride, discrimina-
tive stimulus effects ofethanol, train-
ing dose, NMDA antagonists (rats),
1241Phenobarbital, kinetics of drug action in
disease states, adrenalectomy, painsensitivity (rats), 859
i-Phenylbiguanide, m-chlorophenylbiguan-ide and, behavioral effects (rats),1440
Phenylcyclohexyldiethylamine, phenylcy-clohexylethylamine and, behavioraland pharmacokinetic study (rats),1401
Phorbol myristate acetate, activation of pro-tein kinase C, down-regulation ofnaloxone-resistant receptors, (3-en-dorphin, 276
Phosphodiesterasedecreased sensitivity to cAMP, genera-
tion, memory splenic cytotoxic T-lymphocytes, 1381
isozymes, cyclic nucleotides, colonicsmooth muscle (dogs), 801
isozyme-selective inhibitors, pulmonaryantiallergic and bronchodilator ef-fects (guinea pigs), 609
Phosphoinositide, turnover, muscarinic re-ceptor, tetrahydroaminoacridine(rats), 463
Phospholipase A2competitive inhibition by Ho 19-3704,
suppressive effect, platelet activation(rabbits),1460
distinct signal transduction pathways, an-giotensin II, gastric smooth muscle(guinea pigs), 958
Phospholipase C, activation by carbachol incortical slices, differential effects ofalkylating agents, muscarinic recep-
ton subtypes (rats), 521
Phosphoramidon, peptidase inhibitors, neu-rogenic plasma extravasation, nasalmucosa (rats), 509
Physostigmine, survival during hypoxia,gender differences (mice), 1146
Pietschmann, P., see Farsoudi, K. H., 579Pillar, J. S., see Chen, J. B., 922
Pilocarpine, survival during hypoxia, genderdifferences (mice), 1146
Pirenzepine, autoradiographic mapping, M3muscarinic receptors, brain (rats),
415Pisetsky, D. S., see Spurney, H. F., 584Pitts, D. K., Kelland, M. D., Freeman, A. S.
and Chiodo, L. A.: Repeated amphet-amine administration: Hole of fore-brain in reduced responsiveness ofnigrostriatal dopamine neurons todopamine agonists, 616
Pituitarycell line GH3, somatostatin receptor sub-
types (rats), 110quinpirole binding, dopamine D2 and D3
receptors (rats), 991Plasma, distributional transport kinetics of
zidovudine, brain extracellular fluid,cerebrospinal fluid (rabbits), 899
Plasminogen activatortissue-type
optimized thrombolysis, cerebral clots(rabbits),67
thrombolysis, heparin/aspirin/Ro 43-5054 (dogs), 501
Plateletsbinding and function of BMS 180,291
(humans), 1387stimulation of endogenous prostacyclin,
protection from ischemic injury,myocardium (pigs), 397
suppressive effect on activation, Ho 19-3704, competitive inhibition of phos-pholipase A2 activity (rabbits), 1460
Plesnen, L., see Juul, B., 1234Porreca, F., see Riviere, P. J. M., 1268Porreca, F., see Wild, K. D., 831
Portoghese, P. S., see Miyamoto, Y., 1141Portoghese, P. S., see Wild, K. D., 831Potassium
-induced cytosolic-free Ca�� signals, ef-fects of caffeine, adrenal chromaffincells (pigs), 770
modulation of afferent transmission, se-lective opioid agonists, nucleus trac-tus solitarius (rats), 795
Potassium channel blockerproperties of propafenone, atrial myo-
cytes (rabbits), 1113sodium channel blockers and, interaction,
papillary muscle (guinea pigs), 1056Potassium channels, modulation of low af-
finity binding sites, nucleotides andglibenclamide, brain (rats), 701
Potassium chloride, precontraction, con-traction with rauwolscine, mesen-teric artery (dogs), 201
Potassium current
transient outward, 4-aminopyridineblock, ventricular myocytes (rats),1450
two delayed rectifiers, ventricular myo-cytes, tail current kinetics (guineapigs), 553
Pnather, P. L., Rezazadeh, S. M., Lane, J.D., Rowan, G. A., Hooper, M. L.,Lytle, D. A., Emmett-Oglesby, M. W.and Lai, H.: Conflicting evidence re-garding the efficacy of ondansetron
in benzodiazepine withdrawal, 622Prednisolone, epidermal growth factor, ex-
perimental colitis (rats), 984Pregnancy, orally active nonpeptidyl oxy-
tocin antagonist (rats), 308
1993 Index 1507
Prepiriform cortex, manipulation of endog-enous adenosine, seizure susceptibil-ity (rats), 1415
Preston, K. L. and Bigelow, G. E.: Differ-ential naltrexone antagonism of hy-dromorphone and pentazocine effectsin human volunteers, 813
Price, W. J., see Barnette, M. S., 801Probenecid, distributional transport kinet-
ics, zidovudine, brain extracellularfluid/cerebrospinal fluid (rabbits),899
Prolactin, chronic cocaine disruption, es-trous cyclicity, dose-dependent ef-fects (rats), 29
Propafenone, potassium channel blockingproperties, atrial myocytes (rabbits),1113
Propranolol, regio- and stereoselective me-tabolism, 15 forms of purified cyto-chromes P450, liver (rats), 226
Prostacyclin, endogenous, protection fromischemic injury, myocardium (pigs),397
Prostaglandin E1, effects of NSAIDs, with-drawal responses in ileum, brief ex-posure to morphine (guinea pigs),1028
Prostaglandin endoperoxide, receptor an-tagonist BMS 180,291, pharmacolog-ical profile (humans, rats, cattle,mice, pigs, guinea pigs), 570
Prostaglandinscontractile effects of nucleotides, trachea
(guinea pigs), 210inflammatory mediators, electrolyte
transport, distal colon epithelium(pigs), 61
Prostanoidscontractile effects of nucleotides, trachea
(guinea pigs), 210neurally mediated action of leukotrienes,
ion transport, distal colon (guineapigs), 384
relaxant effects of nucleotides, trachea(guinea pigs), 217
Protein kinase Cactivation, down-regulation of naloxone-
resistant receptors, (3-endorphin, 276subtypes, inhibition by lead, brain (rats),
757
Proud, D., Reynolds, C. J., Broomfield, J.,Goldman, D. W. and Bathon, J. M.:Bradykinin effects in guinea pig tra-cheat epithelial cells are mediatedthrough a B2 kinin receptor and canbe inhibited by the selective antago-nist Hoe 140, 1124
Puberty, luteinizing hormone secretion, fail-ure to reverse inhibitory effect ofmorphine, naloxone (rats), 47
Pullen, M., see Nambi, P., 345S-(6-Purinyl)glutathione, 6-mercaptopu-
rine and, mechanisms of formation,6-chloropurine (rats), 41
Pyrazole, 4-methylpyrazole and, inductionof liver cytochrome P450 2E1, neo-nates (rats), 1468
Pyridostigmine, HI-6 and acetylcholinester-ase, comparison of antidote protec-tion, soman, 1085
Pyrilamine, histamine release and contrac-tion, influence ofepithelium, trachealstrips (guinea pigs), 717
Qian, M., see Gallo, J. M., 315
Quartara, L., see Patacchini, R., 17Quinpirole
binding to D2 and D3 dopamine receptors,brain and pituitary gland, autoradi-ography (rats), 991
comparisons with B-HT 920 and SND919, striatal dopamine and acetylcho-line release, 1344
Rabin, H. A.: Ethanol-induced desenitiza-tion of adenylate cyclase: Role of theadenosine receptor and GTP-bindingproteins, 977
Ranger, S., Sheldon, H., Fermini, B. andNattel, S.: Modulation of felcainide’scardiac sodium channel blocking ac-tions by extracellular sodium: A pos-sible cellular mechanism for the ac-
tion of sodium salts in flecainide car-diotoxicity, 1160
Rao, H. K., see Riviere, P. J. M., 1268Rasmussen, K., Czachura, J. F., Stockton,
M. E. and Howbert, J. J.: Electro-physiological effects of diphenylpyr-azolidinone cholecystokinin-B andcholecystokinin-A antagonists onmidbrain dopamine neurons, 480
Rauwolscine, contraction in mesenteric ar-tery, precontraction with KC1 andendothelin-i (dogs), 201
Hayford, P. L., see Doi, H., 873Raymond, W. W., see Caughey, G. H., 676Raynor, K. and Reisine, T.: Subtypes of
somatostatin receptors are expressedin the anterior pituitary cell GH3, 110
Receptorsbinding, enantiomenic pairs of cannabi-
noids, discriminative stimulus effects(rats, pigeons), 561
B2 kinin, bradykinin effects, inhibition byHoe 140 (guinea pigs), 1124
cannabinoid, aminoalkylindole binding,
cerebellum (rats), 1352cholinergic M2 muscarinic, inhibition of
noradrenaline release, stomach(rats), 54
dopamine, role of forebrain, repeated am-phetamine administration (rats), 616
dopamine D1, autoradiographic localiza-tion, kidney (humans), 431
dopamine D2, ipsilateral rotations, AF64Alesions of striatum (mice), 824
dopamine D3, pharmacologic properties,development of antibodies (rats),1002
dopamine D2 and D3, quinpirole binding,brain and pituitary gland (rats), 991
endothelin, ischemia-induced acute renalfailure (rats), 345
FK5OG characterization and effects, exo-cytotic function, pancreatic acini
(rats), 873
GABAA, trichloroethanol-potentiatedsynaptic transmission, hippocampalneurons, 1097
GABAB and muscarinic m3, seven trans-membrane spanning regions, anti-sense oligodeoxynucleotide to mes-senger HNAs (rats), 423
glycine, anticonvulsant and neuroprotec-tant action, felbamate, 1248
glycoprotein antagonist, thrombolysis,coronary artery reperfusion and reoc-clusion (dogs), 501
guanylate cyclase-coupled, altered neuro-
transmission, atnial natniuretic factor
(rabbits),1227
H2 antagonist, gastroprokinetic activity,nizatidine (dogs, rats), 152
histamine H1 and H2, signal transductionpathways, intestinal muscle cells(guinea pigs), 598
5-HTcisapride and 5-hydroxytryptamine,
motility in antrum (dogs), 79endothelial relaxing, jugular vein (rats),
709
pharmacological profile of AD-5423(mice, rats), 158
rauwolscine, contraction in mesentenic
artery (dogs), 201tone-dependent responses of serotonin,
vascular bed (cats), 13155-HT2
acute and chronic hypertensive mech-anism, ketansenin (rats), 129
tracheal contractile receptor (guineapigs), 271
5-HT3, agonists 1-phenylbiguanide andm-chlorophenylbiguanide, behav-ioral effects (rats), 1440
5-HT4
gastric emptying, SC-49518 (dogs), 240pharmacological analyses, DAU 6285
(rats, guinea pigs), 6545-HT1A
agonist properties, methoxy-chromanderivatives (rats), 863
induction of hypothermia (rats), 1364
tail-flick response and (rats), 955-HT1�, chronic clozapine treatment, cho-
roidplexus (rats), 1262kinin Bi and B2, superior mesenteric an-
tery smooth muscle cells (rabbits),930
N-methyl-D-aspartateantagonist, NPC 17742 (rats, mice, ger-
bils), 256antagonist LY274614, attenuation and
reversal of morphine tolerance (rats),1090
discriminative stimulus, 2-amino-4,5-(1,2-cyclohexyl)-7-phosphonohep-
tanoic acid (rats), 845muscarinic
antimuscarinic agents, intestinal motil-ity (dogs), 789
differential effects of alkylating agents,brain cortical membranes (rats), 521
phosphoinositide turnover, tetrahy-droaminoacridine (rats), 463
muscarinic M3, autoradiographic map-ping, brain (rats), 415
neurotensin, desensitization and down-regulation, N1E-1i5 cells (mice), 1
nicotinic, stimulation of rubidium efflux,
brain synaptosomes (mice), 542nicotinic acetylcholine, redox effects, ner-
eistoxin (chicks), 689opioid, neuroanatomical sites, condi-
tioned place preference paradigm(rats), 489
opioiddeltaforskolin and isobutylmethylxanthine,
NG1O8-15 cells,1474single functional subtype, vas deferens
(mice), 831
opioid delta-2, development of morphinedependence (mice), 1141
1508 Index Vol. 264
opioid epsilon, properties, brain (rats,guinea pigs, cows, pigs, chickens), 349
opioid kappaactivation by U-50,488H, release of
substance P from trigeminal nucleusslices (rats), 648
pharmacological study, 14(3-(thioglyco-lamido)-7,8-dihydro-N(cyclopropylmethyl)-normorph in-one (mice), 1021
opioid mu-2 and alpha adrenergic, mor-phine-induced suppression, spleno-cyte natural killer activity, 1179
opioid mu and kappa, agonists, antago-nism of respiratory effects by U-SO,488H (rats), 631
opioid sigma and muscarinic, centralnervous system binding sites, co-caine-induced seizures and lethality,
1333somatostatin, subtypes, anterior pituitary
cell line GH3 (rats), 110thromboxane
antagonist BMS 180,291, binding andfunction in platelets (humans), 1387
glomerulus, lupus nephritis (mice), 584
Refino, C. J., see Thomas G. H., 67Reimann, W., see Jackisch, H., 889Reisine, T., see Raynor, K., 110Reiss, D. H., see Pettibone, D. J., 308Renin, hormonal and cardiovascular effects,
losartan (monkeys), 6Reserpine, pharmacological analyses of
DAU 6285, tunica muscularis mu-
cosae, ileum (rats, guinea pigs), 654Respiration
antagonist of respiratory effects, U-SO,488H, mu opioid receptor agonists(rats), 631
thermal antinociception, clonidine, dex-medetomidine and xylazine (mon-keys), 762
Respiratory depression, apparent pA2 analy-sis, alfentanil and etonitazene,ethylketocyclazocine and Mr2033(monkeys), 145
Retina, neuronal nicotinic acetylcholine re-ceptors, redox effects, nereistoxin(chicks), 689
Reuveny, E., Twombly, D. A. and Nara-hashi, T.: Chlordiazepoxide block oftwo types of calcium channels inneuroblastoma cells, 22
Reynolds, C. J., see Proud, D., 1124Reynolds, J. M., see Mehvar, H., 662Rezazadeh, S. M., see Prather, P. L., 622Rhim, H., Glaum, S. H. and Miller, H. J.:
Selective opioid agonists modulateafferent transmission in the rat nu-cleus tractus solitarius, 795
Ricaurte, G. A., see Scanzello, C. H., 1484Ricci, A., Escaf, S., Vega, J. A. and Amenta,
F.: Autoradiographic localization ofdopamine D1 receptors in the humankidney , 431
Richelson, E., see Di Paola, E. D., 1Hiker, W. K., see Saiyed, M., 1146Ritz, M. C. and George, F. H.: Cocaine-
induced seizures and lethality appearto be associated with distinct centralnervous system binding sites, 1333
Rivet, J.-M., see Bervoets, K., 95Rivet, J.-M., see Millan, M. J., 1364Riviere, P. J. M., Rao, H. K., Pascaud, X.,
Junien, J. L. and Porreca, F.: Effects
of neuropeptide Y, peptide YY andsigma ligands on ion transport inmouse jejunum, 1268
HNA, messengerantisense oligodeoxynucleotide, receptors
with seven transmembrane spanningregions, cerebellar granule cells(rats), 423
chronic intragastric ethanol infusion, ep-isodic ethanol excretion (rats), 938
Ho 11-2933, reversal of doxorubicin resist-ance (rats), 1299
Ho 19-3704, competitive inhibition of phos-pholipase A2, suppressive effect,platelet activation (rabbits), 1460
Ho 43-5054, coronary artery reperfusion andreocclusion, thrombolysis, tissue-
type plasminogen activator (dogs),501
Robertson, G. S., Tham, C.-S., Wilson, C.,Jakubovic, A. and Fibiger, H. C.: Invivo comparisons of the effects ofquinpirole and the putative presyn-aptic dopaminergic agonists B-HT920 and SND 919 on striatal dopa-
mine and acetylcholine release, 1344Rogers, T. J., see Bussiere, J. L., 591Rolipram
antidepressant-like effects, behavior, dif-ferential reinforcement of low re-sponse rate (rats), 1168
isozyme-selective phosphodiesterase in-hibitors, pulmonary antiallergic andbronchodilator effects (guinea pigs),609
Romanelli, L., see Valeri, P., 1028Ronis, M. J. J., Crouch, J., Mercado, C.,
Irby, D., Valentine, C. H., Lumpkin,C. K., Ingelman-Sundberg, M. andBadger, T. M.: Cytochrome P450CYP 2E1 induction during chronicalcohol exposure occurs by a two-stepmechanism associated with blood al-
cohol concentrations in rats, 944Ronis, M. J. J., see Badger, T. M., 438Roper, L. C., see Gonzales, H. A., 282Roux, S. P., Tschopp, T. B., Kuhn, H.,
Steiner, B. and Hadv#{227}ry,P.: Effectsof heparin, aspirin and a syntheticplatelet glycoprotein llb-llla receptorantagonist (Ho 43-5054) on coronaryartery reperfusion and reocclusionafter thrombolysis with tissue-typeplasminogen activator in the dog, 501
Rovero, P., see Patacchini, H., 17Howan, G. A., see Prather, P. L., 622Rubidium, stimulation of efflux, nicotinic
receptor function, brain synapto-somes (mice), 542
Ruiz, P., see Spurney, H. F., 584Hush, C. H., Higgins, S. T., Bickel, W. K.
and Hughes, J. H.: Acute effects oftriazolam and lorazepam on humanlearning, performance and subjectratings, 1218
Hustum, Y. M., see Alaoui-Jamali, M. A.,1299
RX821002, discrimination and pharmaco-logical characterization, I2-imidazo-line sites, brain (humans, rats), 1187
Hyanodine, cholinergic agonist- and K�-in-duced cytosolic-free Ca�� signals, ef-fects of caffeine, adrenal chromaffincells (pigs), 770
S 14671, induction of hypothermia, S-HT1A
receptor-mediated activity (rats),1364
Sabra, H., see Abets, B. C., 1285Sadowska-Krowicka, H., see Miller, M. J.
S., 11Saifeddine, M., see Yang, S.-G., 958Saiyed, M. and Hiker, W. K.: Cholinergic
and anticholinergic drug effects onsurvival during hypoxia: Significantgender differences, 1146
Sakakibara, Y., see Jia, H., 1275Sall#{233}s,J., Wallace, M. A. and Fain, J. N.:
Differential effects of alkylatingagents on the multiple muscarinic re-ceptor subtypes linked to activationof phospholipase C by carbachol inrat brain cortical membranes, 521
Sarcoplasmic reticulum, alterations of cal-cium dynamics, U46619, cardiomy-
ocytes (rats), 336Sastre, M., see Miralles, A., 1187Satoh, S., see Ogasawara, A., 117Sawchuk, H. J., see Wong, S. L., 899SC-49518, gastric emptying of solid and liq-
uid meals, motility, 5-HT4 receptormechanism (dogs), 240
Scanzello, C. H., Hatzidimitriou, G., Mar-tello, A. L., Katz, J. L. and Ricaurte,G. A.: Serotonergic recovery after (±)-3,4-methylenedioxymethamphe-tamine injury: Observations in rats,1484
Scarpace, P. J., see Bender, B. S., 1381Schafer, S. G., see Ernsberger, P., 172Schecter, H. L., see Alaoui-Jamali, M. A.,
1299Schenken, H. S., see King, T. S., 29Schilling, W. P., see Elliott, S. J., 1063Schizophrenia, electrophysiological effects,
diphenylpyrazolidinone cholecysto-
kinin-B and -A antagonists (rats),480
Schluet, W., see Holzer, P., 391Schmitt, M., see Hechler, V., 1406Schmitz, D. A., see Cho, A. K., 1401Schneider, H. H., see Steppuhn, K. G., 1395Schror, K., see Hohlfeld, T., 397Schumacher, W. A., see Ogletree, M. L., 570Schuurkes, J. A. J., see De Ridder, W. J. E.,
79Seiki, M., see Ueki, S., 152Seizure, susceptibility, manipulation of en-
dogenous adenosine, prepiriform cor-tex (rats), 1415
Seizures, cocaine-induced, lethality, centralnervous system binding sites, 1333
Sellers, E. M., see Higgins, G. A., 1440Sensi, S., see Amoroso, S., 515Seppal#{225},T., see Kuoppamki, M., 1262Serotonin
endothelial relaxing 5-HT receptors, jug-ular vein (rats), 709
-induced contraction in coronary artery,ergolines, vascular 5-HT2-receptorheterogeneity (pigs), 193
pharmacological analyses of DAU 6285,tunica muscularis mucosae, ileum(rats, guinea pigs), 654
recovery after 3,4-methylenedioxyme-thamphetamine injury (rats), 1484
tone-dependent responses, different 5-HT receptors, pulmonary vascularbed (cats), 1315
Sex differences, hormonal regulation ofacetohexamide reductase, postnatal
1993 Index 1509
development, liver and kidney (rats),166
Seyed-Mozaffari A., see Jiang, Q., 1021Shahabi, N. A. and Sharp, B. M.: Activation
of protein kinase C rapidly down-regulates naloxone-resistant recep-tors for f3-endorphin on U937 cells,,276
Shahare, M., see Badger, T. M., 438, 938Sharp, B. M., see Shahabi, N. A., 276Sharpe, L. G., see Katz, J. L., 183Sheldon, H., see Hanger, S., 1160Sheng, J., see Domino, E. F., 221Shepard, D. H., see Apseloff G., 1071Shimamoto, H., see Shimamoto, Y., 201Shimamoto, Y., Shimamoto, H., Kwan, C.-
Y. and Daniel, E. E.: Rauwolscineinduces contraction in the dog mes-enteric artery precontracted withKCI and endothelin-1: Mediation via5-hydroxytryptamine1-like receptors,201
Shippenberg, T. S., see Bals-Kubik, H., 489Shirley, J. T., see Chen, J. B., 922Sholar, J. W., see Mello, N. K., 530Shoubo, M., see Sogabe, K., 1040Showell, H. J., see Chen, J. B., 922Sickels, B. D., see Howell, H. E., 609Siford, G., see Chen, H., 1293Signal transduction
angiotensin II, gastric smooth muscle(guinea pigs), 958
biochemical characterization of FK506,
exocytotic function, pancreatic acini(rats), 873
coexistence of histamine H1 and H2 recep-tors, intestinal muscle cells (guinea
pigs), 598Singer, D. H., see Jia, H., 1275Slawsky, M. T., see Castle, N. A., 1450Smith, J. A., Fraser, D. G. and Fedan, J. S.:
Alteration in the modulatory role ofrespiratory epithelium after exposureof guinea pigs to respirable cottondust, 683
Smith, J. E., see Boundy, V. A., 1002Smith, H. B., see Kroboth, P. D., 1047Smolen, T. N., Brewer, J. A. and Weber, W.
W.: Testosterone modulation of N-acetylation in mouse kidney, 854
SND 919, comparisons with BHT 920 andquinpirole, striatal dopamine andacetylcholine release, 1344
Soares-[da]-Silva, P., Fernandes, H. andPestana, M.: Studies on the role ofsodium on the synthesis of dopaminein the rat kidney, 406
Sodiumextracellular, modulation, flecainide’s
cardiac sodium channel blocking ac-tions, 1160
renal nerve stimulation-induced antina-triuresis, suppression by TMB-8(dogs), 117
synthesis of dopamine in kidney (rats),406
Sodium channel blockers, potassium chan-nel blockers and, interaction, papil-lary muscle (guinea pigs), 1056
Sodium channelsblock by lidocaine, single atrial cells (hu-
mans), 1275contractile effects of nucleotides, trachea
(guinea pigs), 210inhibition of Na�-Ca� exchanger, anoxia
and glucopenia-induced aspartate re-lease, hippocampal slices (rats), 515
modulation of flecainide blocking actions,
extracellular sodium, 1160Sofia, R D., see McCabe, R T., 1248Sogabe, K., Nirei, H., Shoubo, M., Nomoto,
A., Ao, S., Notsu, Y. and Ono, T.:Pharmacological profile ofFH139317, a novel, potent endothelinETA receptor antagonist, 1040
Soman, comparison of antidote protection,pyridostigmine, HI-6 and acetylcho-linesterase, 1085
Sommers, S. L., see Bergsbaken, C. L., 1474Sonntag, W. E., see Breese, C. H., 448Sonoda, J., see Nagakawa, J.-I., 496Spasm, drug-induced, cocaine sensitization,
coronary artery contractions (cattle),1132
Species differences, stereoselective metabo-lism of mephenytoin, cytochromeP450 (rats, rabbits, dogs, monkeys,humans), 89
Spinal cordchronic spinal infusion, dexmedetomi-
dine, ST-91 and clonidine, 3275-HT1A receptors, tail-flick response
(rats), 95Splenocytes, natural killer activity, mor-
phine-induced suppression, alpha ad-renergic and mu-2 opioid receptors,1179
Spurney, H. F., Onorato, J. J., Huiz, P.,Pisetsky, D. S. and Coffman, T. M.:Characterization of glomerularthromboxane receptors in murine lu-pus nephritis, 584
ST-91, dexmedetomidine and clonidine,chronic spinal infusion, aipha-2 adre-noceptor subtypes, 327
Steiner, B., see Roux, S. P., 501Stephens, D. N., see Steppuhn, K. G., 1395Steppuhn, K. G., Schneider, H. H., Turski,
L. and Stephens, D. N.: Long-termtreatment with abecarnil does not in-duce diazepam-like dependence inmice, 1395
Stern, L. S., see Apseloff G., 1071Stevenson, J. I., see Kuster, J. E., 1352Stewart, J. L., see Kostka, P., 234Stockton, M. E., see Rasmussen, K., 480Striatum
AF64A lesions, ipsilateral rotations to D2dopamine agonists (mice), 824
central nervous system tissue, neuro-transmitter release, budipine effects(rabbits), 889
Strobach, H., see Hohifeld, T., 397Stroke, embolic, optimized thrombolysis,
tissue-type plasminogen activator(rabbits), 67
Strychnine, -insensitive glycine receptors,anticonvulsant and neuroprotectantaction, felbamate, 1248
Suarez-Hoca, H. and Maixner, W.: Activa-tion of kappa opioid receptors byU50488H and morphine enhancesthe release of substance P from rattrigeminal nucleus slices, 648
Substance Pactivation of kappa opioid receptors, U-
50,488H and morphine, trigeminalnucleus slices (rats), 648
ascending enteric reflex contraction,propagation of excitation, acetylcho-
line and tachykinins (guinea pigs),391
Sulfamates, organic, ocular pharmacology,carbonic anhydrase inhibitory activ-ity (rabbits), 670
Sulfonylureaglyburide and glipizide, alteration, hepatic
insulin metabolism (rats), 1293modulation of low affinity binding sites,
nucleotides and glibenclamide, brain(rats), 701
Sultana, M., see Wild, K. D., 831Sunaga, K., Chuang, D.-M. and Ishitani, H.:
Tetrahydroaminoacridine is neuro-trophic and promotes the expressionof muscarmnic receptor-coupled phos-phoinositide turnover in differentiat-ing cerebellar granule cells, 463
Superoxide dismutase, effect of arachidonicacid on twitch tension, phrenicnerve-diaphragm (rats), 1311
Suramin, inhibitor, calcemic hormone- andgrowth factor-based bone resorption(mice), 579
Suzuki, T., see Fujita, S., 226Swagler, A. H., see Gallo, J. M., 315Sympathetic nervous system, inhibition of
noradrenaline release from stomach,cholinergic M2 muscarinic receptors(rats), 54
Synapse, potentiation of transmission bytrichloroethanol, mediation by GA-BAA receptors, hippocampal neurons,1097
Synaptosomesbrain, nicotinic receptor function, stimu-
lation of rubidium efflux (mice), 542presynaptic cholinergic actions, DuP 996
(rats), 910Syv#{228}lahti,E., see Kuoppamki, M., 1262
Tabakoff, B., see Liljequist, S., 638Tachykinins
acetylcholine and, ascending enteric re-flex contraction, propagation of ex-citation (guinea pigs), 391
neurokinin A derivatives, agonist and an-
tagonist properties, C-terminal ami-dation (guinea pigs, rabbits, ham-sters, rats), 17
peripheral role, initiation of micturitionreflex (rats), 1327
Tagashira, E., see Ueki, S., 152Takano, Y. and Yaksh, T. L.: Chronic spinal
infusion of dexmedetomidine, ST-91and clonidine: Spinal a�pha� adreno-ceptor subtypes and intrinsic activ-ity, 327
Takeda, S., see Homma, S., 105Takemori, A. E., see Miyamoto, Y., 1141Takemori, A. E., see Wild, K. D., 831Takenaka, T., Forster, H. and Epstein, M.:
Characterization of the renal micro-vascular actions of a new dopami-nergic (DA1) agonist, YM435, 1154
Tanaka-Kagawa, T., Naganuma, A. andImura, N.: Tubular secretion andreabsorption of mercury compunds inmouse kidney, 776
Tandospirone, induction of hypothermia, 5-HT1A i�eptormediated activity(rats), 1364
Tani, M., see Echizen, H., 1425Taylor, S., see Bender, B. S., 1381Tertatolol, induction of hypothermia,
1510 Index Vol. 264
5-HT1A receptor-mediated activity
(rats), 1364Testosterone, modulation of N-acetylation,
kidney (mice), 854Testosterone propionate, hormonal regula-
tion of acetohexamide reductase,postnatal development, liver and kid-ney (rats), 166
Tetrahydroaminoacridine, muscarinic re-ceptor-coupled phosphoinositideturnover, differentiating cerebellargranule cells (rats), 463
Tetrahydrocannabinoid, enantiomeric pairsof cannabinoids, discriminative stim-ulus effects, receptor binding (rats,pigeons), 561
#{244}-9-Tetrahydrocannabinol, delayed matchto sample performance, short-termmemory (rats), 294
Tham, C-S., see Robertson, G. S., 1344Thapsigargin, cholinergic agonist- and K�-
induced cytosolic-free Ca� signals,
effects of caffeine, adrenal chromaf-fin cells (pigs), 770
Theophyllineisozyme-selective phosphodiesterase in-
hibitors, pulmonary antiallergic andbronchodilator effects (guinea pigs),609
kinetics of drug action in disease states,adrenalectomy, pain sensitivity(rats), 859
Thibodeaux, H., see Thomas, G. H., 6714fi-(Thioglycolamido)-7,8-dihydro-
N(cyclopropylmethyl)-normorph in-one, pharmacological study (mice),1021
Thioperamide, histamine release and con-traction, influence of epithelium, tra-cheat strips (guinea pigs), 717
Thomas, G. H., Thibodeaux, H., Bennett,W. F., Refino, C. J., Badillo, J. M.,Errett, C. J. and Zivan, J. A.: Opti-mized thrombolysis of cerebral clotswith tissue-type plasminogen activa-tor in a rabbit model of embolicstroke, 67
Thomas, J. M. and Hoffman, B. B.: Bupren-orphine prevents and reverses theexpression of chronic etorphine-in-duced sensitization of adenylyl cy-clam in SK-N-SH human neuro-blastoma cells, 368
Thomas, P., see Badger, T. M., 438
Thrombin, calcemic hormone- and growthfactor-based bone resorption, sura-mm as inhibitor (mice), 579
Thrombolysiscoronary artery reperfusion and reocclu-
sion, heparin/aspirin/Ro 43-5054,tissue-type plasminogen activator(dogs), 501
optimized, cerebral blots, tissue-type plas-minogen activator (rabbits), 67
Thromboxane, glomerular receptors, lupusnephritis (mice), 584
Thromboxane A2angiotensin II and, postischemic renal
vasoconstriction (dogs), 1285
-prostaglandin endoperoxide receptor an-tagonist, pharmacological profile,BMS 180,291 (humans, rats, cattle,mice, pigs, guinea pigs), 570
receptor antagonist BMS 180,291, bind-ing and function, platelets (humans),
1387
Thromboxane A2 analog, U46619, altera-tions of calcium dynamics, cardiom-yocytes (rats), 336
Tiapamil, analog Ho 11-2933, reversal ofdoxorubicin resistance (rats), 1299
Tidwill, H. H., see Caughey, G. H., 676Tiseo, P. J. and Inturrisi, C. E.: Attenuation
and reversal of morphine toleranceby the competitive N-methyl-D-as-partate receptor antagonist,LY274614, 1090
TMB-8, suppression of renal nerve stimu-lation, induced antinatriuresis(dogs), 117
TNP-470, antitumor effects, microspheresand oil solution, VX-2 carcinoma(rabbits), 469
Toews, M. L., Arneson-Rotert, L. J. andLiewer, S. A.: Bicarbonate inducessensitization of cyclic AMP accumu-lation by intact 1321N1 human astro-cytoma cells, 1211
Toguchi, H., see Kamei, S., 469Tolerance, estimation of effect offset rate
constant, acute tolerance to triazo-lam (humans), 1047
Toraason, M., see Hoffmann, P., 336T#{246}rnebrandt, K., see Bodelsson, M., 709Tortella, F. C., see Dosaka-Akita, K., 631Trachea
contractile effects of nucleotides (guineapigs), 210
contractile receptor, 5-HT2 receptor(guinea pigs), 271
histamine release and contraction, phar-macologic modulation, influence onepithelium (guinea pigs), 717
relaxant effects of nucleotides (guineapigs), 217
respiratory epithelium, alteration in mod-ulatory role, exposure to cotton dust(guinea pigs), 683
Tracheal epithelial cells, bradykinin effects,mediation through B2 kinin receptor,inhibition by Hoe 140 (guinea pigs),1124
Trachte, G. J.,: Atrial natriuretic factor at-ters neurotransmission independ-ently of guanylate cyclase-coupled re-ceptors in the rabbit vas deferens,1227
Traynor, T. H., Brown, D. H. and O’GradyS. M.: Effects of inflammatory me-diators on electrolyte transportacross the porcine distal colon epi-thelium, 61
Triazolamacute tolerance, estimation, effect offset
rate constant (humans), 1047discrimination, selectivity and sensitivity,
novel-response procedure (humans),360
lorazepam and, acute effects, learning andperformance (humans), 1218
1,1,1-Trichloroethane, -produced physicaldependence, effects of drugs and va-pors, withdrawal (mice), 726
Trichloroethanol, potentiation of synaptictransmission, mediation by GABAAreceptors, hippocampal neurons,1097
Trigeminal nucleus caudalis, activation ofkappa opioid receptors, U-50,488Hand morphine (rats), 648
Tninitrobenzenesulfonic acid, epidermalgrowth factor, experimental colitis(rats), 984
Trojnar, J., see Lundin, S., 783Tropea, M. M., Gummelt, D., Herzig, M. S.
and Leeb-Lundberg, L. M. F.: Bi andB2 kinin receptors on cultured rabbit
superior mesenteric artery smoothmuscle cells: Receptor-specific stim-ulation of inositol phosphate forma-tion and arachidonic acid release bydes-Arg�-bradykinin and bradykinin,930
Tropisetron, pharmacological analyses ofDAU 6285, tunica muscularis mu-cosae, ileum (rats, guinea pigs), 654
Tryptases, mast cell, reversible inhibitors,bis(5-amidino-2-benzimidazo-
lyl)methane and related amidines(dogs), 676
Tschopp, T. B., see Roux, S. P., 501d-Tubocurarine, histamine release and con-
traction, influence of epithelium, tra-cheat strips (guinea pigs), 717
Tumor necrosis factor-a, protective effectof E3330, galactosamine-inducedhepatitis (rats), 496
Turski, L., see Steppuhn, K. G., 1395Twombly, D. A., see Heuveny, E., 22Tyrosine kinase, distinct signal transduc-
tion pathways, angiotensin II, gastricsmooth muscle (guinea pigs), 958
U46619, alterations of calcium dynamics,cardiomyocytes (rats), 336
U-5O,488Hactivation of kappa opioid receptors, re-
lease of substance P, trigeminal nu-cleus slices (rats), 648
antagonism of respiratory effects, muopioid receptor agonists (rats), 631
U937 cells, down-regulation of naloxone-resistant receptors, protein kinase Cactivation, (3-endorphin, 276
UDP-glucuronosyltransferase
glucuronidating carboxylic acid-contain-ing drugs, complementary DNA don-ing and expression (humans), 475
repression of drug-metabolizing enzymes,interleukin 1(3, arthritis (rats), 1012
Ueki, S., Seiki, M., Yoneta, T., Aita, H.,Chaki, K., Hori, Y., Morita, H., Ta-gashira, E. and Itoh, Z.: Gastropro-kinetic activity of nizatidine, a newH2-receptor antagonist, and its pos-sible mechanism of action in dogs andrats, 152
Umeda, S., see Fujita, S., 226
Une, T., see Oka, M., 158
Uridine triphosphate, contractile effects ofnucleotides, trachea (guinea pigs),210
Uterusantiuterotonic oxytocin analogs, phar-
macokinetic and pharmacologicproperties (rats), 783
nonpregnant myometrium, adenosine-stimulated contraction, lack of cyclo-oxygenase involvement (guinea pigs),1033
orally active nonpeptidyl oxytocin antag-onist (rats),308
Valentine, C. H., see Honis, M. J. J., 944Valeri, P., Morrone, L. A., Homanelli, L.
1993 Index 1511
and Amico, M. C.: Effect of nonste-roidal anti-inflammatory drugs onwithdrawal responses in guinea pigileum after a brief exposure to mor-phine, 1028
van Belle, K., see Wong, S. L., 899Vargaftig, B. B., see Mounier, C., 1460Vargas, H. M., see Cho, A. K., 1401Vascular bed
hindquarters, inhibitory effects of DuP753 and EXP 3174, angiotensin II(cats),1104
pulmonary, tone-dependent responses ofserotonin, different 5-HT receptors(cats),1315
Vasculature, mesenteric, acute effects ofnicotine, tail artery (rats), 1305
Vas deferensaltered neurotransmission, guanytate cy-
clase-coupled receptors, atrial natri-uretic factor (rabbits), 1227
single functional opioid delta receptorsubtype (mice), 831
Vasoactive intestinal peptide, bis(5-ami-dino-2-benzimidazolyl)methane, re-versible inhibitors, mast cell tryp-
tases (dogs), 676Vasoconstriction, postischemic renal, inter-
action, thromboxane A2 and angio-tensin II (dogs), 1285
Vasodilation, induction by extracellularadenosine 3 ‘ ,5 ‘ -cyclic monophos-phate, pharmacological analysis, cor-onary artery (dogs), 1253
Vasodilators, renal microvascular actions ofYM435 (rats), 1154
Vasopressinantiuterotonic oxytocin analogs, phar-
macokinetic and pharmacologicproperties (rats), 783
orally active nonpeptidyl oxytocin antag-onist (rats), 308
Vega, J. A., see Hicci, A., 431Vein
jugular, endothelial relaxing 5-HT recep-tors (rats), 709
neurokinin A derivatives, agonist and an-tagonist properties, C-terminal ami-dation (guinea pigs, rabbits, hamster,rats), 17
Verapamil, energy level and stimulated in-sulin secretion, islets of Langerhans(rats), 35
Verber, D. F., see Pettibone, D. J., 308Vickroy, T. W.: Presynaptic cholinergic ac-
tions by the putative cognitive en-hancing agent DuP 996, 910
Vignon, J., see Koek, W., 746Virina, M. A., see Gullikson, G. W., 240Vogel, J. H., see McCabe, H. T., 1248
Waikar, M. V., Hegde, S. S., Ford, A. P. D.W. and Clarke, D. E.: Pharmacologi-cal analyses of endo-6-methoxy-8-methyl-8-azabicyclo[3.2.1]oct-3-yl-2,3-dihydro-2-oxo-1H-benzimidazole-1-carboxylate hydrochloride (DAU6285) at the 5-hydroxytryptamine4
receptor in the tunica muscularis mu-cosae of rat and ileum of guinea pig:The role of endogenous 5-hydroxy-tryptamine, 654
Walker, M., see Apseloff G., 1071Wallace, M. A., see Sall#{233}s,J., 521Wambolt, H. B., see Lopaschuk, G. D., 135Wang, L., Chiamvimonvat, N. and Duff, H.
J.: Interaction between selected so-
dium and potassium channel blockersin guinea pig papillary muscle, 1056
Wang, S.-X., see Gullikson, G. W., 240
Ward, S. J., see Kuster, J. E., 1352Wassterstrom, J. A., see Jia, H., 1275Wasterlain, C. G., see McCabe, H. T., 1248Watson, E. G., see Kostka, P., 234Watson, J. W., see Chen, J. B., 922Watts, S. W. and Cohen, M. L.: Further
evidence that the guinea pig trachealcontractile serotonergic receptor is a5-hydroxytryptamine 2 receptor: Useof 5-methyltryptamine and dipropyl-5-carboxamidotryptamine , 271
Webb, M. L., Liu, E. C. K., Monshizadegan,H., Hedberg, A., Misra, H. N., Gol-denberg, H. and Harris, D. N.: Bind-ing and function of a potent newthromboxane receptor antagonist,BMS 180,291, in human platelets,
1387Webb, M. L., see Ogletree, M. L., 570Weber, W. W., see Smolen, T. N., 854Weinger, M. B., see Negus, S. S., 739Weiss, B., see Zhou, L.-W., 824Westbrook, S. L., see Gonzales, H. A, 282White, F. J., see Wolf, M. E., 249Wild, K. D., Carlisi, V. J., Mosberg, H. I.,
Bowen, W. D., Portoghese, P. S., Sul-tana, M., Takemori, A. E., Hruby, V.J. and Porreca, F.: Evidence for asingle functional opioid delta recep-
ton subtype in the mouse isolated vasdeferens, 831
Will, J. A., see Buckner, C. K., 717Willetts, J., see Ferkany, J. W., 256Wilson, C., see Robertson, G. S., 1344WIN 55212-2, binding in cerebellum (rats),
1352Winn, M. J., Asante, N. K. and Ku, D. D.:
Vasomotor responses of canine coro-nary arterial rings to NG-monome-
thyl-L-arginine and Nw nitro L-argi-
nine methyl ester, 265Witkin, J. M., see Katz, J. L., 183Woeppel, S. L., see Howell, H. E., 609Wojcik, W. J., see Holopainen, I., 423Wolf, M. E., White, F. J., Nassar, H., Brood-
erson, H. J. and Khansa, M. H.: Dif-ferential development of autorecep-tor subsensitivity and enhanced do-pamine release during amphetaminesensitization, 249
Wolfe, A. D., see Maxwell, D. M., 1085Wong, S. L., van Belle, K. and Sawchuk, H.
J.: Distributional transport kineticsof zidovudine between plasma andbrain extracellular fluid/cerebrospi-
nat fluid in the rabbit: Investigation
of the inhibitory effect of probenecidutilizing microdialysis, 899
Woods, J. H., see Baron, S. P., 918Woods, J. H., see Butelman, E. H., 145, 762Woyden, C. J., see Pettibone, D. J., 308Wu, D. and Cederbaum, A. I.: Induction of
liver cytochrome P45O2E1 by pyra-zole and 4-methylpyrazole in neona-tat rats, 1468
WY 48,723, WY 50,324 and WY 100,324,induction of hypothermia, 5-HT1A re-ceptor-mediated activity (rats), 1364
Xie, Y., Lane, W. V. and Loring, H. H.:Nereistoxin: A naturally occurringtoxin with redox effects on neuronalnicotinic acetylcholine receptors inchick retina, 689
Xu, Y. and Forsberg, E. J.: Effects of caf-feine on cholinergic agonist- and K�-induced cytosolic-free Ca�� signalsand secretion in porcine adrenalchromaffin cells, 770
Xylazine, clonidine nad dexmedetomidine,thermal antinociception (monkeys),
762
Yaksh, T. L., see Takano, Y., 327Yamada, M., see Di Paola, E. D., 1Yamanaka, T., see Nagakawa, J.-I., 496Yamatsu, I., see Nagakawa, J.-I., 496
Yamazoe, Y., see Yasumoni, T., 89Yanachi, Y., see Imamura, Y., 166Yang, D.-C., see Gullikson, G. W., 240Yang, S.-G., Saifeddine, M., Laniyonu, A.
and Hollenberg, M. D.: Distinct sig-nal transduction pathways for angio-tensin-Il in guinea pig gastric smoothmuscle: Differential blockade by in-
domethacin and tyrosine kinase in-
hibitors, 958Yasumoni, T., Chen, L., Nagata, K., Yama-
zoe, Y. and Kato, H.: Species differ-ences in stereoselective metabolismof mephenytoin by cytochrome P450(CYP2C and CYP3A), 89
Yokotani, K. and Osumi, Y.: Cholinergic M2muscarinic receptor-mediated inhi-
bition of endogenous noradrenalinerelease from the isolated vascularityperfused rat stomach, 54
Yoneta, T., see Ueki, S., 152Yoshioka, T., see Kamei, S., 469Youngren, K. D., Daly, D. A. and Moghad-
dam, B.: Distinct actions of endoge-nous excitatory amino acids on theoutflow of dopamine in the nucleus
accumbens, 289
Yuan, L.-X., see Fedan, J. S., 210, 217
Zabrowski, D. L., see Gullikson, G. W., 240Zalospirone, induction of hypothermia, 5-
HT1A receptor-mediated activity
(rats),1364Zhang, G., Franklin, P. H. and Murray, T.
F.: Manipulation of endogenousadenosine in the rat prepiriform cor-tex modulates seizure susceptibility,1415
Zhang, 5.-P., see Zhou, L.-W., 824Zhou, L.-W., Zhang, 5.-P., Connell, T. A.
and Weiss, B.: AF64A lesions ofmouse striatum result in ipsilateralrotations to D2 dopamine agonistsbut contralateral rotations to mus-carinic cholinergic agonists, 824
Zidovudinedistributional transport kinetics, plasma
and brain extracellular fluid/cerebro-spinal fluid (rabbits), 899
kinetics, nimodipine effects (monkeys),315
Zimmerman, S. A., see Lovinger, D. M., 1097Zini, H., see Zini, S., 701Zini, S., Zini, H. and Ben-An, Y.: Nucleo-
tides modulate the low affinity bind-ing sites for [3H] glibenclamide in therat brain, 701
Zivan, J. A., see Thomas, G. H., 67Zubieta, J. K. and Frey, K. A.: Autoradi-
ographic mapping of M3 muscarinicreceptors in the rat brain, 415
Zubrowski, H., see Ferkany, J. W., 256
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DEPARTMENT OFPHARMACOLOGYThe Department of Pharmacology at Temple
University School of Medicine is seeking tenure-
track members at the ASSISTANT PROFESSORLEVEL. Applicants should have a Ph.D. and/orM.D. degree, postdoctoral experience, anddemonstrated excellence in research. He/she
will be expected to develop a funded researchprogram in molecular pharmacology, interact
with other faculty members, and contribute to
teaching medical, dental and graduate stu-dents. Applicants should submit curriculumvitae, a brief statement of proposed research,
and names and addresses of three references
to: Search Committee, Department ofPharmacology, Temple University School ofMedicine, 3420 North Broad Street,Philadelphia, PA 19140. The deadline forapplications is July, 1, 1993. Temple University
is an Equal Opportunity/Affirmative Action
Employer. Applications from women andminorities are encouraged.
Choose
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