industrial visiting

Dept. of Pharmaceutics

1Vagdevi College Of Pharmacy & Research Center


ABOUT COMPANY

M/s. TWENTY FIRST CENTURY PHARMACEUTICALS PVT LTD., (TFCP) was incorporated on 21st March 1986.

The company has its facility at SIDCO ESTATE, AMBATTUR a suburb of CHENNAI, Tamil Nadu and at ROORKEE, Uttarakhand, India.

The company, as a matter of policy, focuses on only NICHE segments.

Mr. V.S. RAGHUNATHAN, a Technocrat with over 30 years of experience across pharma industry, financial institutions and businesses is the cheif executive.

The Roorkee Factory is 'the State of the art' facility incorporating USFDA / UK MHRA Standards.



PRODUTS

Film Coated Tablets of Amoxycillin 875 mg + Clavulanic Acid 125 mg



Dispersible Tablets of Amoxycillin 200 mg + Clavulanic Acid 28.5 mg

Oral Suspension (Dry Syrup) of Amoxycillin 200 mg + Clavulanic Acid 28.5 mg

Bilayer Tablets of Cefixime 200 mg + Dicloxacillin 500 mg (Extended Release)

Film Coated Tablets of Cefixime 200 mg + Clavulanic Acid 125 mg

Film Coated Tablets of Cefixime 100 mg + Clavulanic Acid 62.5 mg

Dispersible Tablets of Cefixime 100 mg + Clavulanic Acid 62.5 mg



Dispersible Tablets of Cefixime 50 mg + Clavulanic Acid 31.25 mg

Oral Suspension (Dry Syrup) of Cefixime 50 mg + Clavulanic Acid 31.25 mg

Film Coated Tablets of Cefadroxil 500 mg + Clavulanic Acid 125 mg

Dispersible Tablets of Cefadroxil 250 mg + Clavulanic Acid 62.5 mg

Oral Suspension (Dry Syrup) of Cefadroxil 125 mg + Clavulanic Acid 31.25 mg

Film Coated Tablets of Cefpodoxime 200 mg + Clavulanic Acid 125 mg

Film Coated Tablets of Cefpodoxime 100 mg + Clavulanic Acid 62.5 mg

Dispersible Tablets of Cefpodoxime 100 mg + Clavulanic Acid 62.5 mg

Oral Suspension (Dry Syrup) of Cefpodoxime 50 mg + Clavulanic Acid 31.25 mg

Film Coated Tablets of Cefuroxime 500 mg + Clavulanic Acid 125 mg

Film Coated Tablets of Cefuroxime 250 mg + Clavulanic Acid 62.5 mg

Dispersible Tablets of Cefuroxime 125 mg + Clavulanic Acid 31.25 mg

Oral Suspension (Dry Syrup) of Cefuroxime 125 mg + Clavulanic Acid 31.25 mg

We offer either individual molecules or in combination with Clavulanic Acid



Twenty First Century Pharmaceuticals through their highly trained and dedicated staff

provide the bestsolution for your production and marketing needs.We believe that in

today's market we can add greatest value to our products by having an in depth

knowledge of your market place and provide the level of innovation and quality that you

need for success.Knowledge of Raw Materials, Active ingredients and Excipients are

recognized at Twenty First Century Pharmaceuticals, as critical in developing a

successful product.

All ingredients used are of the best quality and thorough analysis is

performed throughout the process.The need to ensure product integrity, the shelf life is

recognized as critical and stability checks are carried out as per I.C.H. guidelines as a

routine practice and the whole process is documented and traceability is ensured.



INTRODUCTION

TABLET - SOLID DOSAGE FORM

Tablets are solid dosage form containing ingredients with or without filler material.

Based on the method of manufacture, can be classified as a printed tablet and compressed

tablet

Compressed tablets are made with high pressure in powder or granule using a steel mold

Printed tablet made by pressing the moist powder mass with low pressure into the mold

hole. The density of the tablet depends on the bond crystals formed during the drying

process, it has been very rarely used


http://formulation.vinensia.com/2011/02/tablet-solid-dosage-form.html

http://www.google.co.in/imgres?imgurl=http://cdn.nursingcrib.com/wp-content/uploads/image/pill.PNG&imgrefurl=http://nursingcrib.com/drug-guides/oral-dosage-forms-that-should-not-be-crushed/&usg=__NlCccUGM64S3Mkb6NOo-DiorXSI=&h=378&w=298&sz=216&hl=en&start=14&zoom=1&tbnid=5eZZ7VzARoinQM:&tbnh=122&tbnw=96&ei=SwUHTqOhD4PRrQfe1bmwDA&prev=/images%3Fq%3DTABLET%2Bdosage%2Bforms%26start%3D10%26hl%3Den%26sa%3DX%26tbm%3Disch%26prmd%3Divns&itbs=1


FORMS & CLASSIFICATION of TABLET

Based on the route of administration or its functions, drug delivery systems and forms

and methods of manufacture, the tablet can be classified as follows:

1. Oral tablets for Eaten

• Compressed Tablets / CT

• Double Layer/Multiple Compressed Tablets / MCT) -Coated Tablets -Felt a coated tablet • Tablet with repeated reaction

• Sugar coated and Sugar chocolate coated tablet

• Film-coated tablet

• Chewing Tablet

2. Tablets Used in Mouth cavity

• buccal tablet

• Sublingual Tablets

• Troche or lozenges

3. Tablet Provided by Other Routes

• Implantation Tablet

• Vaginal Tablets



4. Tablets Used To Make Solvent

• effervescent tablets

• hypodermic tablet

• Triturat tablets

THE ADVANTAGES OF TABLET DOSAGE FORM

tablet is intact dosage form and offers the best capabilities of all oral dosage forms for

accuracy in size and content of the lowest variability

tablet dosage form which is the lowest cost of manufacture (if it is calculated per dose)

Tablets is an oral dosage form of the lightest, most compact, easiest and most inexpensive

way to packed and shipped

The product identification on the tablets the most easy and inexpensive, requiring no

additional work steps when using the printer surface that monogram or arising accesories

Tablet can be used as a product of specific release profiles, such as the release in the

intestine or slow release products

Tablets is an oral dosage form of the most easy to be produced in bulk (large scale)

THE DISADVANTAGES OF TABLET DOSAGE FORM

Some drugs can not be compressed into solid and compact, depending on its amorphous

state, flocculation, or low density.

Drugs moistened difficult, slow dissolves, moderate or high dose, high optimum

absorption via the gastrointestinal tract or any combination of the properties above, it



would be difficult or impossible to be formulated and fabricated in the form of tablets

that produce sufficient drug bioavaibility

Medicine that tastes bitter, a drug with the smell was terrible and can not be eliminated,

or drugs that are sensitive to oxygen or air humidity needs to encapsulation or

compression cloaking before (if possible) or require coating first. In this case, the capsule

is a cheaper way out

Tablet properties

Tablets can be made in virtually any shape, although requirements of patients and

tableting machines mean that most are round, oval or capsule shaped. More unusual

shapes have been manufactured but patients find these harder to swallow, and they are

more vulnerable to chipping or manufacturing problems.

Tablet diameter and shape are determined by the machine tooling used to produce them –

a die plus an upper and a lower punch are required. This is called a station of tooling. The

thickness is determined by the amount of tablet material and the position of the punches

in relation to each other during compression. Once this is done, we can measure the

corresponding pressure applied during compression. The shorter the distance between the

punches, thickness, the greater the pressure applied during compression, and sometimes

the harder the tablet. Tablets need to be hard enough that they don't break up in the bottle,

yet friable enough that they disintegrate in the gastric tract.

Tablets need to be strong enough to resist the stresses of packaging, shipping and

handling by the pharmacist and patient. The mechanical strength of tablets is assessed



using a combination of (i) simple failure and erosion tests, and (ii) more sophisticated

engineering tests. The simpler tests are often used for quality control purposes, whereas

the more complex tests are used during the design of the formulation and manufacturing

process in the research and development phase. Standards for tablet properties are

published in the various international pharmacopeias (USP/NF, EP, JP, etc.).

MANUFACTURING AND FORMULATION PROCESS

FORMULATION Film Coated Tablets of Cefixime 200 mg + Clavulanic Acid 125 mg +

Exicipents.

Manufacture of the tableting blend

In the tablet pressing process, the main guideline is to ensure that the appropriate amount

of active ingredient is in each tablet. Hence, all the ingredients should be well-mixed. If a

sufficiently homogenous mix of the components cannot be obtained with simple blending

processes, the ingredients must be granulated prior to compression to assure an even

distribution of the active compound in the final tablet. Two basic techniques are used to

granulate powders for compression into a tablet: wet granulation and dry granulation.

Powders that can be mixed well do not require granulation and can be compressed into

tablets through direct compression.

Wet granulation

Wet granulation is a process of using a liquid binder to lightly agglomerate the powder

mixture. The amount of liquid has to be properly controlled, as over-wetting will cause



the granules to be too hard and under-wetting will cause them to be too soft and friable.

Aqueous solutions have the advantage of being safer to deal with than solvent-based

systems but may not be suitable for drugs which are degraded by hydrolysis.

Procedure

Step 1: The active ingredient and excipients are weighed and mixed.

Step 2: The wet granulate is prepared by adding the liquid binder–adhesive to

the powder blend and mixing thoroughly. Examples of binders/adhesives

include aqueous preparations of cornstarch, natural gums such as acacia,

cellulose derivatives such as methyl cellulose, gelatin, and povidone.

Step 3: Screening the damp mass through a mesh to form pellets or granules.

Step 4: Drying the granulation. A conventional tray-dryer or fluid-bed dryer

are most commonly used.

Step 5: After the granules are dried, they are passed through a screen of

smaller size than the one used for the wet mass to create granules of uniform

size. Low shear wet granulation processes use very simple mixing equipment,

and can take a considerable time to achieve a uniformly mixed state. High

shear wet granulation processes use equipment that mixes the powder and liquid at a very

fast rate, and thus speeds up the manufacturing process. Fluid bed granulation is a

multiple-step wet granulation process performed in the same vessel to pre-heat, granulate,

and dry the powders. It is used because it allows close control of the granulation process.

Dry granulation

Dry granulation processes create granules by light compaction of the powder blend under


http://en.wikipedia.org/wiki/Gelatin


low pressures. The compacts so-formed are broken up gently to produce granules

(agglomerates). This process is often used when the product to be granulated is sensitive

to moisture and heat. Dry granulation can be conducted on a tablet press using slugging

tooling or on a roll press called a roller compactor. Dry granulation equipment offers a

wide range of pressures to attain proper densification and granule formation. Dry

granulation is simpler than wet granulation, therefore the cost is reduced. However, dry

granulation often produces a higher percentage of fine granules, which can compromise

the quality or create yield problems for the tablet. Dry granulation requires drugs or

excipients with cohesive properties, and a 'dry binder' may need to be added to the

formulation to facilitate the formation of granules.

Granule lubrication

After granulation, a final lubrication step is used to ensure that the tableting blend does

not stick to the equipment during the tableting process. This usually involves low shear

blending of the granules with a powdered lubricant, such as magnesium stearate or stearic acid.

Manufacture of the tablets

Whatever process is used to make the tableting blend, the process of making a tablet by

powder compaction is very similar. First, the powder is filled into the die from above.

The mass of powder is determined by the position of the lower punch in the die, the

cross-sectional area of the die, and the powder density. At this stage, adjustments to the

tablet weight are normally made by repositioning the lower punch. After die filling, the

upper punch is lowered into the die and the powder is uniaxially compressed to a porosity 12

Vagdevi College Of Pharmacy & Research Center

http://en.wikipedia.org/wiki/Stearic_acid

http://en.wikipedia.org/wiki/Stearic_acid

http://en.wikipedia.org/wiki/Magnesium_stearate


of between 5 and 20%. The compression can take place in one or two stages (main

compression, and, sometimes, pre-compression or tamping) and for commercial

production occurs very fast (500–50 msec per tablet). Finally, the upper punch is pulled

up and out of the die (decompression), and the tablet is ejected from the die by lifting the

lower punch until its upper surface is flush with the top face of the die. This process is

simply repeated many times to manufacture multiple tablets.

Common problems encountered during tablet manufacturing operations include:

poor (low) weight uniformity, usually caused by uneven powder flow into the die

poor (low) content uniformity, caused by uneven distribution of the API in the tableting

blend

sticking of the powder blend to the tablet tooling, due to inadequate lubrication, worn or

dirty tooling, and sub-optimal material properties

capping, lamination or chipping. Such mechanical failure is due to improper formulation

design or faulty equipment operation.

Tablet compaction simulator

Tablet formulations are designed and tested using a laboratory machine called a Tablet

Compaction Simulator or Powder Compaction Simulator. This is a computer controlled

device that can measure the punch positions, punch pressures, friction forces, die wall

pressures, and sometimes the tablet internal temperature during the compaction event.

Numerous experiments with small quantities of different mixtures can be performed to

optimise a formulation. Mathematically corrected punch motions can be programmed to



simulate any type and model of production tablet press. Initial quantities of active pharmaceutical ingredients are very expensive to produce, and using a Compaction

Simulator reduces the amount of powder required for product development.

Tablet presses

The tablet pressing operation


http://en.wikipedia.org/wiki/File:Tablet_press_animation.gif

http://en.wikipedia.org/wiki/File:Tablet_press_animation.gif


An old Cadmach rotary tablet pressTablet presses, also called tableting machines, range

from small, inexpensive bench-top models that make one tablet at a time (single-station

presses), with only around a half-ton pressure, to large, computerized, industrial models

(multi-station rotary presses) that can make hundreds of thousands to millions of tablets

an hour with much greater pressure. The tablet press is an essential piece of machinery

for any pharmaceutical and nutraceutical manufacturer. Common manufacturers of tablet

presses include Fette, Korsch, Kikusui, Manesty, IMA and Courtoy. Tablet presses must

allow the operator to adjust the position of the lower and upper punches accurately, so

that the tablet weight, thickness and density can each be controlled. This is achieved

using a series of cams, rollers, and/or tracks that act on the tablet tooling (punches).


http://en.wikipedia.org/wiki/Tablet_press

http://en.wikipedia.org/wiki/File:Old_tablet_press.jpg

http://en.wikipedia.org/wiki/File:Old_tablet_press.jpg


Mechanical systems are also incorporated for die filling, and for ejecting and removing

the tablets from the press after compression. Pharmaceutical tablet presses are required to

be easy to clean and quick to reconfigure with different tooling, because they are usually

used to manufacture many different products.Tablet coating.

Many tablets today are coated after being pressed. Although sugar-coating was popular in

the past, the process has many drawbacks. Modern tablet coatings are polymer and

polysaccharide based, with plasticizers and pigments included. Tablet coatings must be

stable and strong enough to survive the handling of the tablet, must not make tablets stick

together during the coating process, and must follow the fine contours of embossed

characters or logos on tablets. Coatings are necessary for tablets that have an unpleasant

taste, and a smoother finish makes large tablets easier to swallow. Tablet coatings are

also useful to extend the shelf-life of components that are sensitive to moisture or

oxidation. Special coatings (for example with pearlescent effects) can enhance brand

recognition.If the active ingredient of a tablet is sensitive to acid, or is irritant to the

stomach lining, an enteric coating can be used, which is resistant to stomach acid, and

dissolves in the less acidic area of the intestines. Enteric coatings are also used for

medicines that can be negatively affected by taking a long time to reach the small

intestine, where they are absorbed. Coatings are often chosen to control the rate of

dissolution of the drug in the gastrointestinal tract. Some drugs will be absorbed better at

different points in the digestive system. If the highest percentage of absorption of a drug

takes place in the stomach, a coating that dissolves quickly and easily in acid will be

selected. If the rate of absorption is best in the large intestine or colon, then a coating that

is acid resistant and dissolves slowly would be used to ensure it reached that point before dispersing.


http://en.wikipedia.org/wiki/Small_intestine

http://en.wikipedia.org/wiki/Small_intestine

http://en.wikipedia.org/wiki/Stomach

http://en.wikipedia.org/wiki/Enteric_coating

http://en.wikipedia.org/wiki/Pigment

http://en.wikipedia.org/wiki/Plasticizer

http://en.wikipedia.org/wiki/Polysaccharide

http://en.wikipedia.org/wiki/Polymer


The Tablet Coating Process

Many solid pharmaceutical dosage mediums are produced with coatings, either on the

external surface of tablets, or on materials dispensed within gelatine capsules. Coating

serves a number of purposes:

Protects the tablet (or the capsule contents) from stomach acids

Protects the stomach lining from aggressive drugs such as enteric coated aspirin

Provides a delayed release of the medication

Helps maintain the shape of the tablet

Ideally, the tablet should release the material gradually and the drug should be available

for digestion beyond the stomach. The coating can be specially formulated to regulate

how fast the tablet dissolves and where the active drugs are to be absorbed into the body

after ingestion.

Many factors can affect the end-use properties of pharmaceutical tablets:

Chemical composition

Coating process

Drying time

Storage and environmental monitoring

Coating Process Design & Control



Tablet coating takes place in a controlled atmosphere inside a perforated rotating drum.

Angled baffles fitted into the drum and air flow inside the drum provide means of mixing

the tablet bed. As a result, the tablets are lifted and turned from the sides into the centre

of the drum, exposing each tablet surface to an even amount of deposited/sprayed

coating.

The liquid spray coating is then dried onto the tablets by heated air drawn through the

tablet bed from an inlet fan. The air flow is regulated for temperature and volume to

provide controlled drying and extracting rates, and at the same time, maintaining the

drum pressure slightly negative relative to the room in order to provide a completely

isolated process atmosphere for the operator.

Tablet coating equipment may include spray guns, coating pan, polishing pans, solution

tanks, blenders and mixers, homogenizers, mills, peristaltic pumps, fans, steam jackets,

exhaust and heating pipes, scales and filters. Tablet coating processes may include sugar

coating (any mixtures of purified water, cellulose derivatives, polyvinyl, gums and sugar)

or film coating (purified water, cellulose derivatives).



The coating process is usually a batch driven task consisting of the following phases:

Batch identification and Recipe selection (film or sugar coating)Loading/Dispensing (accurate dosing of all required raw materials)

WarmingSpraying (application and rolling are carried out simultaneously)

Drying

Cooling

Unloading

A control system must therefore provide flexibility in the way in which accurate and

repeatable control of the coating environment is achieved and will include the following

features:

Precise loop control with setpoint profile programming

Recipe Management System for easy parameterization

Sequential control for complex control strategies

Secure collection of on-line data from the coating system for

analysis and evidence

Local operator display with clear graphics and controlled access to parameters

The EyconTM Visual Supervisor is an ideal solution for the tablet coating process.

Types of Tablet Coating

Tablet coating means covering tablets with one or more than one layers of materials like

natural or synthetic resins ,gums ,inactive and insoluble filler, sugar, plasticizer,

polyhydric alcohol, waxes, authorized coloring material and some times flavoring

material. There are various types of tablet coating techniques which are described below :


http://industry-mart.blogspot.com/2011/01/types-of-tablet-coating.html


Sugar Coating

Sugar coating involves coating tablets with colored or uncolored sugar layer. This coating

is soluble in water and dissolves completely when swallowed. Apart from improving the appearance of the tablet, sugar coating makes it easy to imprint manufacturing

information on tablet. It increases the size and weight of the tablet. Sugar coating is a five

stage process involving following steps:

Sealing/water proofing

Sub coating

Grossing/smoothing

Coloring

Polishing Film Coating

In film coating, a thin layer of polymer is applied on the tablet core. Film coating

involves the use of film formers namely Hydroxy Propyl Methyl Cellulose

(HPMC),Methyl Hydroxy Ethyl Cellulose (MHEC),Ethyl Cellulose (EC),Hydroxy

Propyl Cellulose (HPC), Povidone,Sodium carboxy methyl cellulose,Polyethylene

glycols (PEG),Acrylate polymers.

Enteric Coating

The tablet core gets disintegrated in the environment, so to prevent disintegration, enteric

coating is used. This type of coating may be a one layer system or two layer system. It is

non toxic, cheap and resists gastric fluids.

Specialized Coating



Compressed coating, electrostatic coating, dip coating, vacuum film coating are

specialized coating techniques involving the use of a special machine.

Coating Pan

Specially designed to apply seasoning to fried product in uniform manner

All contact parts are made of SS 304

Specification: 1 Hp Motor 3 phase

Weight: 75 Kg

Dimensions: 3 x 4 x 5 Ft

Capacity: 5-15 Kg per Batch

EQUIPMENTS

Autocoaters

Applications : Coater type SCS can be used to coat pallets, granules and tablets.


http://www.pharma-machinery.co.in/autocoaters.html

http://www.google.co.in/imgres?imgurl=http://www.krka.biz/media/si/img/mediji/fotoarhiv/ljutomer/o/drazirna_naprava.jpg&imgrefurl=http://www.krka.biz/en/mediji/fotoarhiv/%3Fv%3Dljutomer&usg=__WD-mBBf5i8C82QbpDslfl1I1cEM=&h=1890&w=2835&sz=2380&hl=en&start=1&zoom=1&tbnid=SK0pEXUGP1sq4M:&tbnh=100&tbnw=150&ei=4Q0HTpChM4qurAeD47i8DA&prev=/images%3Fq%3Dtablet%2Bcoating%26hl%3Den%26sa%3DX%26tbm%3Disch&itbs=1


Autocoaters are designed for the application of :

Film coating with organic solvent.

Film coating with aqueous coating.

Sugar coating.

Salient Features :

Automated process.

Conforms to cGMP.

Flexible batch operations.

Product protective handling to prevent chipping of tablets.

Complete separation of production and technical area.

These autocoaters or tablet autocoaters are extremely user friendly software and

operation through PLC.

Excellent mixing and tumbling by special design of baffles.

The autocoaters are made up of entirely of S.S.316.

Advanced CIP system.

Treatment of exhaust air for pollution free operation

LABORATORY DOUBLE ARM SIGMA BLADE MIXERS



Laboratory Mixers are available in sizes ranging from 1/4 gallon to 3 gallon working

capacity. Variable speed drive on the blades standard. Stainless steel construction

standard, jacketed is standard.

Double Cone Blender

Our customers can avail from us Double Cone Blenders, which are highly efficient and

versatile machines, used in number of manufacturing and industrial applications. These

are used for mixing dry powder and granules homogeneously. Manufactured using finest

grade material, these are based on latest technology available in the industry. Offered at



industry-leading prices, our products are used in food, pharmaceutical, cosmetic and

chemical industries.

Slugging Tablet Press

Dosage Form: Tablet

Type: Preparation Machinery

Applications

ZPW15A/B rotary tablet press can be used in a variety of applications. It is suitable not

only to the pharmaceutical and foodstuff industry but also the chemical, ceramic,

electronic and battery industry for pressing different granular materials into tablets.

Multi Punch Tablet Machine



Features of our Multi Punch Tablet Machine: * Ground crank and gun

metal bushes. * Machine cut gears. * Easy to adjust. * Easy to

maintain. * Easy lubrication of grease only. * 1 HP 3 Phase electric

motor. * Speed 50 stroke/minute.

Tray Dryer


http://www.pharma-machinery.co.in/tray-dryer.html


1) CONSTRUCTION :

EXTERNAL:2MM THKINTERNAL:2MM THKMOC: cGMP

2) SURFACE FINISH : EXTERNAL:

Buffed to 150 grit matt finish INTERNAL: Buffed to 220 grit mirror finish.

3) INLET & OUTLET :

All pharmaceutical tray dryer and industrial tray dryer have a 5 micron pre filter at the inlet and a manually

infinite adjustable damper at the outlet.

4) DOOR : In these pharmaceutical tray dryer and industrial tray dryer doors at provided at the front and / or rear side of

the dryer. Door lips are lined with silicon rubber gasket to prevent any leakages. Suitable locking is

provided for the doors.

Tablet Compression / Coating Isolator



Telstar Ace, has the experience in installation and commissioning of bespoke isolators to

contain a fully automated tablet presses and coaters.

The process of integrating the tablet press within an isolator starts with an ergonomic

model constructed around the press during the pre-engineering phase, enabling the client

and Telstar ACE to maximise the area's most important for operator production and maintenance.

Successful integration is a challenge, Telstar ACE a world leading containment specialist

enjoys and excels in this type of project, supplying containment solutions and bespoke

units to end users and OEM suppliers".

Portable Stirrer



Varity of stirrers can fulfill the exact need of the production. These stirrers are different from traditional

stirrers

The telescopic construction enables complete extraction and insertion and

portable design assures multiple use of the stirrer.

PU wheels with turning facility make it easy to carry the stirrer anywhere on the shop floor.

Speed variation is controlled through VFD

STRIP PACKING MACHINE :

Is a high speed Packing suitable for a variety of products, such as tablets, dragees and

capsules. High quality sealing is achieved with features such as proportional temperature

controls, variable sealing roller pressure and rugged and precision construction.



Blisterpack Machine

Automatic Blister Packing Machine(400 Blister/min)


http://www.kwangdah.com/kdb-240.htm




Multifunctional Automatic Alu-Alu Packing Machine

packaging machine ,packaging machinery ,drawing length driven by servo motor , with

high precision transmission....


This KDB-240 is a high-speed double linesautomatic blister packing (Press Through Package (PTP)) machine.It automatically heats the PVC then forming,feeding, sealing, embossing, perforating &trimming.It can be used for the pharmaceutical packing(tablets, capsules, pills, and etc...), food and othersimilar products packing.Max. Capacity: 400 Blisters/Minute.

http://www.alibaba.com/product-gs/230666354/Multifunctional_Automatic_Alu_Alu_Packing_Machine.html


Strip Packaging

Strip packaging is a cost-effective packaging solution that enables small-sized tablets

and capsules to be packed in unit doses for distribution. Among the numerous packaging

solutions that Nutricap Labs offers, strip packaging is by far the most popular because of

its many unique advantages.

Benefits of Strip Packaging:

Strip packaging is economical.

Strip packaging provides your customers with organized packaging of their tablets or

capsules.

Strip packaging offers a more user-friendly packaging solution than bottled tablets and

capsules.

Strip packaging protects your product from physical and environmental damage during transit and storage.

Blister pack


http://www.nutricaplabs.com/capsule-manufacturer.aspx

http://www.nutricaplabs.com/tablet-manufacturer.aspx






Blister pack is a term for several types of pre-formed plastic packaging used for small

consumer goods, foods, and for pharmaceuticals.

The primary component of a blister pack is a cavity or pocket made from a "formable"

web, usually a thermoformed plastic. This usually has a backing of paperboard or a

"lidding" seal of aluminum foil or plastic. A blister that folds onto itself is often called a

clamshell.

ALU PACKING

ALBLIS-I is a versatile ‘Flat Plate’ intermittent motion automatic Alu Alu Blister

Packing Machine that can produce Alu-Alu blister packs by cold forming method as well


http://en.wikipedia.org/wiki/Clamshell_(container)

http://en.wikipedia.org/wiki/Aluminum_foil

http://en.wikipedia.org/wiki/Paperboard

http://en.wikipedia.org/wiki/Packaging

http://www.google.co.in/imgres?imgurl=http://www.prowestcoatings.com/images/products/blister_pills.jpg&imgrefurl=http://www.prowestcoatings.com/&usg=__nZtte8oESfIbVjQ5nXNb5zuj_Ig=&h=287&w=300&sz=22&hl=en&start=16&zoom=1&tbnid=dPbjuP_4zq-nGM:&tbnh=111&tbnw=116&ei=Ui8HTrP_AYrrrQf70fGnDA&prev=/images%3Fq%3Dblister%2Bpacking%26hl%3Den%26sa%3DX%26tbm%3Disch&itbs=1


as PVC-Alu blister packs by thermoforming method. This Alu Alu Blister Packing

Machine is utilized for packing of smaller and regular shaped solid articles such as

pharmaceutical tablets, capsules, dragees etc., in Alu-Alu or PVC-Alu blister packs. This

Alu Alu Blister Packing Machine can also be used for packing of Ampoules, Vials, Tubes

as well as cream. paste, jam etc in PVC-Alu blister packs. The Blister Forming, Sealing,

Indexing and Punching operations are of intermittent reciprocating motion. Various types

and styles of product feeding devices are offered to suit different application.

The output capacity of the Alu Alu Blister Packing Machine depends on the product

characteristics and thus on the type of feeding device. Normally for cold forming

operation to produce Alu-Alu blisters this machine would operate at 25 cycles per minute

and for thermoforming operation to produce PVC-Alu blisters it would operate at 40

cycles per minute.


http://www.alibaba.com/product-gs/440817303/pharma_laminated_alu_alu_foil_blister.html


CONCLUSION

This industrial visit is very useful to us as i have known about the

standards and procedures to be followed in the production,

Formulation, storage& packing of products.


industrial visiting

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