INFECTION AND IMMUNITY

VoItlume 5 C OContents for JanU arr beNi1 1

Bacterial and Mycotic InfectionsHost Factors and Capsular Typing of Body Fluid Isolates in Fulminant Pneumococcal

Infections. RONALD M. SHAPERA AND JOHN M. MATSEN....................... 132

Viral InfectionsAge-Associated Changes in Fecal Excretion Patterns of Strain 93 Chick Embryo

Lethal Orphan Virus in Chicks. D. I. CLEMMER............................. 60Foot-and-Mouth Disease Virus: Selection by Homogenized Calf Kidney Adsorption

and Cell Culture Passage. C. H. CAMPBELL................................. 65Effect of Exogenous Interferon on L Cells Persistently Infected with Newcastle Disease

Virus. JULES V. HALLUM, HARSHAD R. THACORE, AND JULIUS S. YOUNGNER .. 145

Pathogenic Mechanisms, Ecology, and EpidemiologyChanges in the Mouse Intestinal Microflora During Weaning: Role of Volatile Fatty

Acids. ADRIAN LEE AND ERICA GEMMELL................................... IMycoplasmosis: Serology of Infections in the Genital Tract of Bulls. H. ERNo... 20Antiglobulins in Endocarditis. JOHN P. PHAIR, JACK KLIPPEL, AND MALCOLMI R.

MACKENZIE............................................ 24Chemical Properties of the Pili of CorYnebactericiniienale. NORICHIKA KUMAZAWA

AND RYo YANAGAWA..........2............27Relationship of Serogroups of Neisseria meningitidis. 11. R Variants of Neisser iai

meningitidis. LEONARD F. DEVINE, SOLON L. RHODE III, AND CLINE R. HAGERMAN.. 48Isolation and Characterization of Mycoplasma co;juntictivae sp. n. from Sheep and Goats

with Keratoconjunctivitis. MICHAEL F. BARILE, RICHARD A. DEL GIUDICE, ANDJOSEPH G. TULLY...........7.0................70

Experimental Tularemia in Macaca mtulatta: Relationship of Aerosol Particle Size to theInfectivity of Airborne Pasteurella tllarenisis. WILLIAM C. DAY AND RICHARD F.BERENDT................. 77

Classification of Neisseria meningitidis Group B into Distinct Serotypes. I. SerologicalTyping by a Microbactericidal Method. CARL E. FRASCH AND S. STEPHENCHAPMAN .......................................................... 98

Factors Affecting Virulence of Shigellaflexneri: Strain with Relaxed Control of Ribo-nucleic Acid Synthesis. SARA W. ROTHMAN AND LAURENCE M. CORWIN.103

In Vitro Bactericidal and Associated Metabolic Activities of Mouse Spleen Cells. R. R.STRAUSS, B. B. PAUL, A. A. JACOBS, AND A. J. SBARRA.114

Mouse Splenic Peroxidase and Its Role in Bactericidal Activity. R. R. STRAUSS, B. B.PAUL, A. A. JACOBS, AND A. J. SBARRA.120

Mycoplasmacidal Activity of Peroxidase-H202-Halide Systems. A. A. JACOBS, I. E.Low, B. B. PAUL, R. R. STRAUSS, AND A. J. SBARRA.127

Transient Increase in Capillary Permeability Induced by Clostiridium peifr'in1genis TypeA Enterotoxin. RAYMOND L. STARK AND CHARLES L. DUNCAN................ 147

ImmunologySerological Typing of Staphylococcus epidermidis Strains by the Serum-Soft Agar

Technique. KOSAKU YOSHIDA, MELVIN R. SMITH, AND YOSHIKo NAITO ........ 8Isolation and Characterization of a Leptospiral Type-Specific Antigen. M. SHINAGAWA

AND R.YANAGAWA...................................................... 12Experimental Oral Immunization with L-Forms of Vibrio cholerae. S. C. AGARWAL

AND N. K. GANGULY ........................ ............................ 3 1Immune Response to Cryptococcuis neoformanis Soluble Polysaccharide. I. Serological

Assay for Antigen and Antibody. THOMAS R. KOZEL AND JOHN CAZIN, JR...... 35Recall of Acquired Cellular Resistance in Mice by Antigens from Killed Brucella.

BARBARA L. HALLIBURTON AND RONALD D. HINSDILL......................... 42

Conitittiied o11Jollonvioig page

Con tilli ]eti,'0)i1 pr'ecleding Page

Specific Hemagglutinin and a Modulator of Complement in Cockroach Hemnolymnph.ROBERT S. ANDERSON, NOORBIBI K. B. DAY, AND ROBERT A. GooD............. 55

Degree of Immunity Induced by Killed Vaccines to Experimental Salmonellosis in Mice.MENDEL HERZBERG, PETER NASH, AND SHARON HINO......................... 83

Immunochemistry of the Streptococcal Group R Cell Wall Polysaccharide Antigen.PANDU SOPREY AND HUTTON D. SLADE .... ................... 91

Genetic Control of Host Responses to Endotoxin. BARNET M. SULTZER... 107Hemagglutination Assay of Antibodies Associated with Pulmonary Acariasis in Rhesus

Monkeys (Macaca mulatta). CHIN S. KIM, FREDERIK B. BANG, AN) RONALDF. DIGIACOMO ............... ..... ........... ...... 137

Comparison of Capsular Types of Staphylococcus aureus Strains. KoSAKU YOSHIDAAND YOSHIKo NAITO ...................................................... 143

Volume 5 Contents for January Number 1Bacterial and Mycotic Infections

Host Factors and Capsular Typing of Body Fluid Isolates in Fulminant PneumococcalInfections. RONALD M. SHAPERA AND JOHN M. MATSEN...................... 132

Viral InfectionsAge-Associated Changes in Fecal Excretion Patterns of Strain 93 Chick Embryo

Lethal Orphan Virus in Chicks. D. I. CLEMMER .. 60Foot-and-Mouth Disease Virus: Selection by Homogenized Calf Kidney Adsorption

and Cell Culture Passage. C. H. CAMPBELL................................. 65Effect of Exogenous Interferon on L Cells Persistently Infected with Newcastle Disease

Virus. JULES V. HALLUM, HARSHAD R. THACORE, AND JULIUS S. YOUNGNER..... 145

Pathogenic Mechanisms, Ecology, and EpidemiologyChanges in the Mouse Intestinal Microflora During Weaning: Role of Volatile Fatty

Acids. ADRIAN LEE AND ERICA GEMMELL................................... 1Mycoplasmosis: Serology of Infections in the Genital Tract of Bulls. H. ERN0 ...... 20Antiglobulins in Endocarditis. JOHN P. PHAIR, JACK KLIPPEL, AND MALCOLM R.

MACKENZIE.............................................................. 24Chemical Properties of the Pili of Corynebacterium renale. NORICHIKA KUMAZAWA

AND RYo YANAGAWA........................................................27Relationship of Serogroups of Neisseria meningitidis. II. R Variants of Neisseria

meningitidis. LEONARD F. DEVINE, SOLON L. RHODE III, AND CLINE R. HAGERMAN.. 48Isolation and Characterization of Mycoplasma conjunctivae sp. n. from Sheep and Goats

with Keratoconjunctivitis. MICHAEL F. BARILE, RICHARD A. DEL GIUDICE, ANDJOSEPH G. TULLY........................................................ 70

Experimental Tularemia in Macaca mulatta: Relationship of Aerosol Particle Size to theInfectivity of Airborne Pasteurella tularensis. WILLIAM C. DAY AND RICHARD F.BERENDT............................................................... I. 77

Classification of Neisseria meningitidis Group B into Distinct Serotypes. I. SerologicalTyping by a Microbactericidal Method. CARL E. FRASCH AND S. STEPHENCHAPMAN............................................................... 98

Factors Affecting Virulence of Shigella flexneri: Strain with Relaxed Control of Ribo-nucleic Acid Synthesis. SARA W. ROTHMAN AND LAURENCE M. CORWIN........ 103

In Vitro Bactericidal and Associated Metabolic Activities of Mouse Spleen Cells. R. R.STRAUSS, B. B. PAUL, A. A. JACOBS, AND A. J. SBARRA .......... .............. 114

Mouse Splenic Peroxidase and Its Role in Bactericidal Activity. R. R. STRAUSS, B. B.PAUL, A. A. JACOBS, AND A. J. SBARRA ...................... 120

Mycoplasmacidal Activity of Peroxidase-H202-Halide Systems. A. A. JACOBS, I. E.Low, B. B. PAUL, R. R. STRAUSS, AND A. J. SBARRA ................. 127

Transient Increase in Capillary Permeability Induced by Clostridium perfringens TypeA Enterotoxin. RAYMOND L. STARK AND CHARLES L. DUNCAN................ 147

ImmunologySerological Typing of Staphylococcus epidermidis Strains by the Serum-Soft Agar

Technique. KOSAKU YOSHIDA, MELVIN R. SMITH, AND YOSH1Ko NAITO......... 8Isolation and Characterization of a Leptospiral Type-Specific Antigen. M. SHINAGAWA

AND R. YANAGAWA......................... 12Experimental Oral Immunization with L-Forms of Vibrio cholerae. S. C. AGARWAL

AND N. K. GANGULY .................................................... 31Immune Response to Cryptococcus neoformans Soluble Polysaccharide. I. Serological

Assay for Antigen and Antibody. THOMAS R. KOZEL AND JOHN CAZIN, JR...... 35Recall of Acquired Cellular Resistance in Mice by Antigens from Killed Brucella.

BARBARA L. HALLIBURTON AND RONALD D. HINSDILL......................... 42Specific Hemagglutinin and a Modulator of Complement in Cockroach Hemolymph.

ROBERT S. ANDERSON, NOORBIBI K. B. DAY, AND ROBERT A. GOOD............. 55,

CONTENTS xv

Degree of Immunity Induced by Killed Vaccines to Experimental Salmonellosis in Mice.MENDEL HERZBERG, PETER NASH, AND SHARON HINO......................... 83

Immunochemistry of the Streptococcal Group R Cell Wall Polysaccharide Antigen.PANDU SOPREY AND HUTTON D. SLADE....:................................. 91

Genetic Control of Host Responses to Endotoxin. BARNET M. SULTZER............ 107Hemagglutination Assay of Antibodies Associated with Pulmonary Acariasis in Rhesus

Monkeys (Macaca mulatta). CHIN S. KIM, FREDERIK B. BANG, AND RONALDF. DIGIACOMO........................................................... 137

Comparison of Capsular Types of Staphylococcus aureus Strains. KOSAKU YOSHIDAAND YOSHIKO NAITO...................................................... 143

Volume 5 Contents for February Number 2Bacterial and Mycotic Infections

Prolonged Stationary Phase Growth of T-Strain Mycoplasmas in Broth Culture.J. OWEN HENDLEY AND ELIZABETH N. ALLRED ............................... 164

Inhibition of 3H-Uridine Uptake in Mouse Macrophages Infected with Mycobacteriumlepraemurium. KEIKO OZATO AND KOJI OIWA.............................. 255

Viral InfectionsExperimental Venezuelan Equine Encephalomyelitis Virus Infection of the Bovine.

THOMAS E. WALTON AND KARL M. JOHNSON................................. 155Photodynamic Treatment of Herpes Keratitis. CONRAD MOORE, CRAIG WALLIS,

JOSEPH L. MELNICK, AND MICHAEL D. KUNS................................ 169Chronic Infection of the Rabbit Central Nervous System by a Slowly Growing Equine

Herpesvirus. G. PLUMMER, P. L. COLEMAN, AND D. HENSON................... 172

Pathogenic Mechanisms, Ecology, and EpidemiologyEffect of Exposure to the Atmosphere on the Infectivity of Group A Streptococci.

KITI SRISUPARBH AND WILLIAM D. SAWYER.................................. 176Fatal Anaphylaxis-Like Reaction Induced by Yeast Mannans in Nonsensitized Mice.

L. S. KIND, P. KAUSHAL, AND P. DRURY.................................... 180Host-Parasite Relationships in Experimental Streptobacillus moniliformis Arthritis in

Mice. N. L. SAVAGE.......................................... .......... 183Salmonellosis in Orally Infected Specific Pathogen-Free C57B1 Mice. F. M. COLLINS... 191Effect of an Interferon Stimulator, Polyinosinic:Polycytidylic Acid, on Experimental

Fungus Infections. MICHAEL WORTHINGTON AND HERBERT F. HASENCLEVER. 199Ultrastructural Changes in Cells of the Mouse Footpad Infected with Mycobacterium

leprae. M. J. EVANS AND LOUIS LEVY.....................................238Neuraminidase Activity in Mycoplasma gallisepticum. K. K. SETHI AND H.E. MULLER. 260Use of Specifically Labeled Sucrose for Comparison of Extracellular Glucan and

Fructan Metabolism by Oral Streptococci. C. F. SCHACHTELE, A. E. LOKEN, ANDM. K. SCHMITT.........................................................263

Inhibition of In Vitro Plaque Formation byL-Lysine. F.J. MALVEAUX AND J. J. SMITH.. 267

ImmunologyDifferential Immune Response to Attenuated Rubella Virus Vaccine. JIBAN D. GUPTA,

VINCENT J. PETERSON, AND ALAN M. MURPHY ............................... 151Field Studies of an Attenuated Venezuelan Equine Encephalomyelitis Vaccine (Strain

TC-83). GERALD A. EDDY, DAVID H. MARTIN, WILLIAM C. REEVES, AND KARL M.JOHNSON........................ ....... 160

Antibody Formation to Trehalose-6,6'-Dimycolate (Cord Factor) of Mycobacteriumtuberculosis. MASAHIKO KATO............................................. 203

Production of Potent Anti-Australia Antigen Sera of High Specificity and Sensitivity inGoats. GORDON R. DREESMAN, F. BLAINE HOLLINGER, ROBERT M. MCCOMBS, ANDJOSEPH L. MELNICK....................................................... 213

XVi CONTENTS

Vibriofetus Infection in Man: a Serological Test. VICTOR BOKKENHEUSER ......... . 222Screening of Sera for Antibodies to Foot-and-Mouth Disease Viral Antigens by Radial

Immunodiffusion. G. G. WAGNER, K. M. COWAN, AND J. W. MCVICAR.......... 227Development of Bactericidal Capacity and Phagocytosis-Associated Metabolism of

Fetal Pig Leukocytes. BEULAH HOLMES, NOORBIBI DAY, JUDY HASEMAN, ANDROBERT A. GOOD....................................... ........ ...... 232

Complement-Fixing Antigens of Herpes Simplex Virus Types 1 and 2: Reactivity ofCapsid, Envelope, and Soluble Antigens. MARY LANE MARTIN, ERSKINE L. PALMER,AND ROBERT E. KISSLING.................................................. 248

Immunochemical Identification of a Defined Antigen of Mycobacterium leprae. SERGIOESTRADA-PARRA.......................................................... 258

Volume 5 Contents for March Number 3Bacterial and Mycotic Infections

Infection-Immunity in Tularemia: Specificity of Cellular Immunity. J. LATHAMCLAFLIN AND CARL L. LARSON ........... .................................. 311

Latex Agglutination Test for Measurement of Antibodies to Meningococcal Polysac-charides. EDMUND C. TRAMONT AND MALCOLM S. ARTENSTEIN................. 346

Viral Infections

Isolation from Mouse Spleen of Cell Populations with High Specific Infectivity forScrapie Virus. G. C. LAVELLE, L. STURMAN, AND W. J. HADLOW.............. 319

Biological Activity of a Partially Purified Inhibitor of Vaccinia Virus Hemagglutinin.STEPHEN C. W. LAU AND W. A. CASSEL .................................... 359

Serological Relationships Among Herpesviruses: Cross-Reaction Between Marek'sDisease Virus and Pseudorabies Virus as Detected by Immunofluorescence. J. M.SHARMA, D. BURGER, AND S. G. KENZY..................................... 406

Ocular Pathogenicity of Types 1 and 2 Herpesvirus hominis in Rabbits. J. 0. OH,G. B. MOSCHINI, AND T. STEVENS........................................... 412

Pathogenic Mechanisms, Ecology, and EpidemiologyCarbohydrate Metabolism and Survival of Endotoxin-Poisoned Mice Given Trypto-

phan. ROBERT J. MOON................................... 288Inactivation of the Hemagglutinins of Type A Influenza Viruses by Physical and Chemi-

cal Means: an Aid to Classification. ROY CLEELAND, E. GRUNBERG, AND HERBERTN. PRINCE................................... 324

Influence of Gonadectomy on Candida albicans Urinary Tract Infection in CFW Mice.DAVID RIFKIND AND JANET A. FREY................................... 332

Vascular Permeability *Factor of Pseudomonas aeruginosa. HIDEO KUSAMA ANDROBERT H. SUss................................... 363

Suppression of the Intracellular Growth of Shigella flexneri in- Cell Cultures by Inter-feron Preparations and Polyinosinic-Polycytidylic Acid. L. L. GOBER, A. E.FRIEDMAN-KIEN, E. A. HAVELL, AND J. VILCEK............................. . 370

Efficiency of Plating on Chick Embryo Cells and Kinetic Neutralization of Herpesvirushominis Strains. BERTTINA B. WENTWORTH AND SHARON L. ZABLOTNEY.......... 377

In Vivo Release of Previously Cleared Interferon by Cycloheximide. THOMAS J.CHESTER, ERIK DE CLERCQ, MARC R. NUWER, AND THOMAS C. MERIGAN.......... 383

Induction of L-Variants in Human Diploid Cells Infected by Group A Streptococci.JANINE SCHMITT-SLOMSKA, ANDRE BOUE, AND RENE CARAVANO ................. 389

Location of Feline Leukemia-Sarcoma Group-Specific Antigen in Infected HumanTissue Cultare Cells. TITo R. UBERTINI.................................... 400

4C-Glucose Oxidation in Whole Blood: a Clinical Assay of Phagocyte Dysfunction.GERALD T. KEUSCH, STEVEN D. DOUGLAS, DONNA MILDVAN, AND SHALOM Z.HIRSCHMAN.............................................................. 414

x*iiCONTENTS

Xviii CONTENTS

ImmunologyPurification of Immunogenically Active Ribonucleic Acid Preparations of Salmonella

typhimurium: Molecular-Sieve and Anion-Exchange Chromatography. MARTINR. VENNEMAN............................................................ 269

Microbicidal Activity of Peroxidaseless Chicken Heterophile Leukocytes. KAY BRUNE,M. S. LEFFELL, AND J. K. SPITZNAGEL....................................... 283

Enteric Immunization with Live Adenovirus Type 21 Vaccine. I. Tests for Safety, In-fectivity, Immunogenicity, and Potency in Volunteers. BURTON A. DUDDING,PETER J. BARTELLONI, ROBERT M. SCOTT, FRANKLIN H. Top, JR., PHiLIP K. RUSSELL,AND EDWARD L. BUESCHER..................................295

Enteric Immunization with Live Adenovirus Type 21 Vaccine. II. Systemic and LocalImmune Responses Following Immunization. ROBERT MCNMR SCOTT, BURTONA. DUDDING, SALVATORE V. ROMANO, AND PHiLIP K. RUSSELL................. 300

Antibodies to Surface Antigens of Herpesvirus Type 1- and Type 2-Infected Cells AmongWomen with Cervical Cancer and Control Women. JERRY W. SMITH, SANDRAP. LOwRY, JOSEPH L. MELNICK, AND WILLIAM E. RAWLS ...................... 305

Ontogeny of the Phytohemagglutinin Response of Fetal Piglet Thymic and SplenicLymphocytes. GLENN E. RODEY, NORBIBI DAY, BEULAH HOLMES-GRAY, ANDROBERT A. GOOD........................................................ 337

In Vitro Stimulation of Hamster Lymphocytes with Concanavalin A. S. B. SINGHAND S. S. TEVETHIA.. ............................ ........... 339

Demonstration of Cytotoxic Antibodies in Rabbits Bearing Tumors Induced by ShopeFibromaVirus. S. B. SINGH, J. W. SMITH, W. E. RAWLS, AND S. S. TEvHrA. . . 352

Effect of Storage on the Ability of 2-Mercaptoethanol to Inactivate 'yM Antibody.ROBERT M. PIKE AND CLEO H. CHANDLER................................... 416

Volume 5 Contents for April Number 4Bacterial and Mycotic Infections

Infection at the Subcellular Level. I. Localization of Intravenously Injected Brucellae inthe Vacuolar Apparatus of Cells of Guinea Pig Liver. HUMBERTO GUERRA, RUSSELLL. DETER, AND ROBERT P. WILLIAMS ........................................ 513

Viral InfectionsAlkaline and Acid Phosphatase in Murine Leukemia. DONALD A. WILSON, NARSINGH

N. SHARMA, AND ERIC R. BROWN........................................... 461Iguana Virus, a Herpes-Like Virus Isolated from Cultured Cells of a Lizard, Iguana

iguana. H. FRED CLARK AND DAVID T. KARZON.............................. 559Electron Microscopy Observations on a New Herpes-Type Virus Isolated from Iguana

iguana and Propagated in Reptilian Cells In Vitro. R. F. ZEIGEL AND H. F.CLARK................................................................. 570

Pathogenic Mechanisms, Ecology, and EpidemiologyAdherence Inhibition of Streptococcus mutans: an Assay Reflecting a Possible Role of

Antibody in Dental Caries Prophylaxis. GERALD A. OLSON, ARNOLD S. BLEIWEIS,AND PARKER A. SMALL, JR................................................. 419

Binucleate Classical Mycoplasmas Pathogenic for Goats. GEOFFREY FURNESS ANDMARIA DE MAGGIO... .................................... 433

Circadian Rhythm of the Resistance of Mice to Acute Pneumococcal Infection. MAIWONGWIWAT, SIRIMANA SUKAPANIT, CHALERMLARP TRIYANOND, AND WILLIAM D.SAWYER................................................................ 442

Cell Wall Composition of Two Strains of Blastomyces dermatitidis Exhibiting Differ-ences in Virulence for Mice. REBECCA A. Cox AND GARY K. BEST.............. 449

Characterization and Comparison of Mycobacterial Antigens by Discontinuous PoreGradient Gel Electrophoresis. LEWIS F. AFPRoNTI, GEORGE L. WRIGHT, JR., ANDMELVIN REICH........................................................... 474

Characterization and Comparison of Mycobacterial Antigens by Two-DimensionalPolyacrylamide Gel Electrophoresis. GEORGE L. WRIGHT, JR., LEWIS F. AFFRONTI,AND MELVIN REICH ......................... ............................. 482

In Vitro Phagocytosis and Intracellular Fate of Variously Encapsulated Strains of Cryp-tococcus neoformans. THOMAS G. MITCHELL AND LORRAINE FREIDMAN.......... 491

Development of Tetracycline-Resistant Staphylococcus aureus in Gnotobiotic Mice.GEORGE H. BORNSIDE, BETTE B. BORNSIDE, AND ISIDORE COHN, JR ........... 505

Agglutination of Staphylococcus aureus by Rabbit Sera. ARNE FORSGREN AND URBANFORSUM..................................................................524

Preferential Utilization of the Glucosyl Moiety of Sucrose by a Cariogenic Strain ofStreptococcus mutans. C. F. SCHACHTELE, A. E. LOKEN, AND D. J. KNUDSON..... 531

Effect of Dihydrostreptomycin on Phagocytosis of Mouse-Peritoneal MacrophagesIn Vitro. DIETER ADAM, FRITZ STABER, BERND H. BELOHRADSKY, AND WALTERMARGET ...................................................................537

Immunological Distinction of Mycobacterial Beta-Lactamases. JOHN S. THOMPSON,CHARLES D. SEVERSON, NANCY A. STEARNS, AND JOHN E. KASIK ............ 542

Association of Escherichia coli with the Small Intestinal Epithelium. I. Comparison ofEnteropathogenic and Nonenteropathogenic Porcine Strains in Pigs. HANS U.BERTSCHINGER, HARLEY W. MOON, AND SHANNON C. WHIPP .............. 595

Association of Escherichia coli with the Small Intestinal Epithelium. II. Variations inAssociation Index and the Relationship Between Association Index and Entero-sorption in Pigs. HANS U. BERTSCHINGER, HARLEY W. MOON, AND SHANNON C.WHIPP.................................................................. 606

Plasmid-Associated Enterotoxin Production in a Strain of Escherichia coli Isolated fromHumans. F. J. SKERMAN, S. B. FORMAL, AND STANLEY FALKOW . .......... 622

Characterization of Deoxyribonucleic Acid from Yersinia pestis by Ethidium Bromide-Cesium Chloride Density Gradient Centrifugation. ROSELYN V. LITTLE ANDROBERT R. BRUBAKER ............ 630

Amino Acid Oxidase in Leukocytes: Evidence Against a Major Role in Phagocytosis.LAWRENCE R. DECHATELET, CHARLES E. MCCALL, AND M. ROBERT COOPER....... 632

Failure of Cholera Enterotoxin to Alter Cyclic 3',5'-Adenosine Monophosphate-Mediated Responses in Toad Urinary Bladder. PHILIP D. LIEF AND GERALD T.KEUSCH................................................................ 634

ImmunologyImmunity to Vibrio cholerae in the Mouse. I. Passive Protection of Newborn Mice.

DONALD PITKIN AND PAUL ACTOR ................... .................... 428Prenatal Immunization by the Oral Route: Stimulation of Brucella Antibody in Fetal

Lambs. MARVIS RICHARDSON AND GABEL H. CONNER........................ 454Soluble Antigen of Blue-Tongue Virus. C. S. WANG, D. C. LUEKER, AND T.

L. CHOW............................................................... 467Correlation of Increased Metabolic Activity, Resistance to Infection, Enhanced Phago-

cytosis, and Inhibition of Bacterial Growth by Macrophages from Listeria- andBCG-Infected Mice. KENNETH R. RATZAN, DANIEL M. MUSHER, GVALD T.KEUSCH, AND LoUis WEINSTEIN .......................... 499

Cross-Protective Antigens of Neisseria meningitidis Obtained from Slaterus Group Y.H. J. JENNINGS, A. MARTIN, C. P. KENNY, AND B. B. DIENA..................... 547

In Vitro Response of Human Lymphocytes to Mycoplasma pneumoniae. GERALD W.FERNALD........................I ..................................... 552Antigen-Mediated Fusion of Specifically Sensitized Rabbit Alveolar Macrophages.

B. GALINDO........................... .................583Characterization of Spheroplast Membranes ofNeisseria meningitidis Group B. JAMESC. HILL, NOEL R. PETERSON, AND EMILIO WEISS............................... 612

Hemagglutinin Response of Human Subjects to Common Enterobacterial Antigen. E.A. GORZYNSKI, C. J. VAN Oss, J. L. AMBRUS, AND E. NETER..................... 625

Serum and Nasal Secretion Immune Response in Meningococcal Disease. RICHARDP. WENZEL, JOHN R. MITZEL, JOHN A. DAVIES, AND WALTER E. BEAM, JR ......... . 627

XiXCONTENTS

CONTENTS

Volume 5 Contents for May Number5Bacterial and Mycotic Infections

Staphylococcidal Capability of Rabbit Peritoneal Macrophages in Relation to Infec-tion and Elicitation: Delayed-Type Hypersensitivity Without Increased Resistance.NANCY LENHART AND STUART MUDD.................... .................. 757

Staphylococcidal Capability of Rabbit Peritoneal Macrophages in Relation to Infectionand Elicitation: Induction and Elicitation of Activated Macrophages. NANCYLENHART AND STUART MUDD............................................. 763

Ultrastructural Study of the Behavior of Macrophages Toward Parasitic Mycobacteria.P. D'ARCY HART, J. A. ARMSTRONG, CAROLYN A. BROWN, AND P. DRAPER....... 803

Viral InfectionsDifferential Susceptibility of Male and Female Mice to Encephalomyocarditis Virus:

Effects of Castration, Adrenalectomy, and the Administration of Sex Hormones.STANFORD B. FRIEDMAN, LEE J. GROTA, AND LOWELL A. GLASGOW.............. 637

Interferon in Nasal Secretions and Sera of Calves After Intranasal Administrationof Avirulent Infectious Bovine Rhinotracheitis Virus: Association of Interferon inNasal Secretions with Early Resistance to Challenge with Virulent Virus. J. D.TODD, F. J. VOLENEC, AND I. M. PATON..................................... 699

Zoonotic Infections in Military Scout and Tracker Dogs in Vietnam. A. D. ALEX-ANDER, L. N. BINN, B. ELISBERG, P. HUSTED, D. L. HUXSOLL, J. D. MARSHALL, JR.,C. F. NEEDY, AND A. D. WHITE............................................ 745

Experimental Infection of Horses with an Attenuated Venezuelan Equine Encephalo-myelitis Vaccine (Strain TC-83). THOMAS E. WALTON, OTTO ALVAREZ, JR.,Ross M. BUCKWALTER, AND KARL M. JOHNSON.............................. 750

Pathogenic Mechanisms, Ecology, and EpidemiologyAutoimmunity in Experimental Trypanosoma congolense Infections of Rabbits.. JOHN

M. MANSFIELD AND JULIUS P. KREIER................................ 648Correlation of M Protein Production with Those Factors Found to Influence Growth

and Substrate Utilization of Streptococcus pyogenes. LEO PINE AND MICHAEL W.REEVES........................................ I ................ 668

Experimental Paracoccidioidomycosis in Mice. LEONOR I. LINARES AND LORRAINEFRIEDMAN ............................................................ 681

Experimental Pneumococcal Infection in Embryonated Eggs Previously Infected withInfluenza C Virus. LOUIS E. BLOUSE AND G. JOHN BUDDINGH. 688

Sex Difference in Antibody Response of CFW Mice to Candida albicans. DAVIDRIFKIND AND JANET A. FREY.695

Studies of the Rickettsial Plaque Assay Technique. DAVID A. WIKE, GEORGE TALLENT,MARIUS G. PEACOCK, AND RICHARD A. ORMSBEE.715

Isolation by Electrofocusing ofTwo Lymphocyte Mitogens Produced by Staphylcocccusaureus. ARNOLD S. KREGER, GIROLAMO CUPPARI, AND ANGELO TARANTA........ 723

Pathogenesis of Tularemia in Monkeys Aerogenically Exposed to Francisella tularensis425. ROBERT L. SCHRICKER, HENRY T. EIGELSBACH, JOHN Q. MITTEN, AND WIL-LIAM C. HALL....... 734

Mutation in Shigella flexneri 2a Resulting in Increased Electrophoretic Mobility.LAURENCE M. CORWIN AND LEONARD A. TALEVI............................. 798

Effects of Purified Staphylococcal Alpha Toxin on the Ultrastructure of Human andRabbit Erythrocytes. ALBERT S. KLAINER, TE-WEN CHANG, AND LOUIS WEINSTEIN. 808

M Protein-Associated Adherence of Streptococcus pyogenes to Epithelial Surfaces: Pre-requisite for Virulence. R. P. ELLEN AND R. J. GIBBONS....................... 826

Specific and Nonspecific Staining in Detecting Staphylococcal Alpha Toxin on Erythro-cytes by Immunofluorescence. MILTON T. KAPLAN.......................... 831

ImmunologyAntigenic Cross-Reactivity of Staphylococcal Enterotoxins. HOWARD M. JOHNSON,

JOANN A. BUKOVIC, AND PETER E. KAUFFMAN................................. 645

xx

Mycoplasma pneumoniae Vaccine: Antigenicity of Buffered Antigens in Volunteers.RICHARD C. BROWN, J. OWEN HENDLEY, AND JACK M. GWALTNEY, JR........... 657

Experimental Studies on Cholera Immunization. II. Evidence for Protective AntitoxicImmunity Mediated by Serum Antibodies as Well as Local Antibodies. J. HOLM-GREN, A. ANDERSSON, G. WALLERSTROM, AND 0. OUCHTERLONY................ 662

Chemical Composition and Immunological Specificity of the Streptococcal Group 0Cell Wall Polysaccharide Antigen. HIDEHIKO MUKASA AND HUTrON D. SLADE.. 707

Natural and Immune Antibodies for Vibrio fetus in Serum and Secretions of Cattle.J. R. DUNCAN, B. N. WILKIE, AND A. J. WINTER............................. 728

Effect of Antithymocyte Serum on Experimental Toxoplasmosis in Mice. ORJANSTRANNEGARD AND ERIK LYCKE .......................................... 769

Contribution of Humoral and Cellular Factors to the Resistance to ExperimentalInfection by Pseudomonas aeruginosa in Mice. II. Opsonic, Agglutinative, and Pro-tective Capacities of Immunoglobulin G Anti-Pseudomonas Antibodies. ANN B.BJORNSON AND J. GABRIEL MICHAEL........................................ 775

Time Relationships Between Injection of Antigen and Adjuvant. III. Adjuvancy ofBordetella pertussis Given at Various Times After the Primary Antigenic Stimulus.H. FINGER, P. EMMERLING, AND L. PLAGER.................................. 783

Immunity in Experimental Salmonellosis. III. Comparative Immunization with Viableand Heat-Inactivated Cells of Salmonella typhimurium. R. GERMANIER........ 792

Activity of Macrophage and Neutrophil Cellular Fractions from Normal and ImmuneSheep Against Listeria monocytogenes. P. M. OUTTERIDGE, J. W. OSEBOLD, ANDY. C. ZEE............................................................... 814

Isolation of an Additional Capsular-Type Strain of Staphylococcus aureus by the Serum-Soft Agar Technique. KOSAKU YOSHIDA................................... 833

Volume 5 Contents for June Number6

Bacterial and Mycotic InfectionsPathogenesis and Immunological Aspects of Experimental Histoplasmosis in Cynomol-

gus Monkeys (Macaca fascicularis). W. KAPLAN, L. KAUFMAN, AND H. M.MCCLURE.................................. 847

Immunochemistry and End-Group Analyses of Group A Streptococcal M Proteins.DAVID C. STRAUS AND CHARLES F. LANGE................................. 927

Viral InfectionsIndirect Hemagglutination Test for Varicella-Zoster Infection TORU FURUKAWA

AND STANLEY A. PLOTKIN.................................. 835Interferon-Inducing Polycarboxylates: Mechanism of Protection Against Vaccinia Virus

Infection in Mice. A. BILLIAU, J. J. MUYEMBE, AND P. DE SOMER.............. 854Study of the One-Step Growth Curve of Equine Infectious Anemia Virus by Immuno-

fluorescence. CHUZO USHIMI, JAMES B. HENSON, AND JOHN R. GORHAM........ 890Infection of Genital Tract and Transmission of Ocular Infection to Newborns by the

Agent of Guinea Pig Inclusion Conjunctivitis. DAVID T. MOUNT, PIERLUIGI E.BIGAZZI, AND ALMEN L. BARRON.......................................... 921

Characteristics of a Swine Papovavirus. JOSEPH T. NEWMAN AND KENDALL 0. SMITH. . 961

Pathogenic Mechanisms, Ecology, and EpidemiologyMycoplasma-Virus Interrelationships in Mouse Tracheal Organ Cultures. STEPHEN

C. WESTERBERG, CHARLES B. SMITH, BILL B. WILEY, AND CYNTHIA JENSEN.......... 840Mechanisms of Pathogenesis in Listeria monocytogenes Infection. V. Early Imbalance in

Host Energy Metabolism During Experimental Listeriosis. R. E. MCCALLUMAND C. P. SWORD...........................''I'll, ...................... 863

Mechanisms of Pathogenesis in Listeria monocytogenes Infection. VI. Oxidative Phos-phorylation in Mouse Liver Mitochondria During Experimental Listeriosis.R. E. MCCALLUM AND C. P. SWORD........................................ 872

XXiCONTENTS

Adenovirus Susceptibility to Human Interferon During One-Step Replication. JAMESG. GALLAGHER AND NEWTON KHOOBYARIAN............................. 905

Serological Comparisons Among Hart Park Virus and Strains of Flanders Virus.KENNETH R. BOYD....................................................... 933

Selective Effects of Thermal Injury on Mouse Peritoneal Macrophages. C. WAYNESMITH AND A. S. GOLDMAN......................................... ........938

Experimental Infection of the Skin in the Hamster Simulating Human Impetigo. IV.Cellular Responses After Streptococcal and Staphylococcal Infections. ADNAN S.DAJANI AND LEWIS W. WANNAMAKER....................................... 942

Respiratory Diseases in Cyclophosphamide-Treated Mice. I. Increased Virulence ofMycoplasma pulmonis. S. H. SINGER, M. FORD, AND R. L. KIRSCHSTEIN ..... ..... 953

Respiratory Diseases in Cyclophosphamide-Treated Mice. II. Decreased Virulence ofPR8 Influenza Virus. S. H. SINGER, P. NOGUCHI, AND R. L. KIRSCHSTEIN......... 954

Phagocytosis of Microbial L-Forms. HERBERT J. HARWICK, LUCIANO BARAJAS, JOHNZ. MONTGOMERIE, GEORGE M. KALMANSON, AND LUCIEN B. GUZE................ 976

Immunology

Immunochemical Parameters of Some Commercial Conjugates for the FluorescentTreponemal Antibody-Absorption Test. E. F. HUNTER, J. F. SMITH, J. S. LEWIS,B. E. MCGREW, AND J. D. SCHMALE........................................ 858

Cytoplasmic Antigens from Nocardia Eliciting a Specific Delayed Hypersensitivity.LIBRADO ORTIZ-ORTIZ, MAGDALENA F. CONTRERAS, AND LuIs F. BOJALIL.......... 879

Immunogenicity of Egg-Grown Influenza Vaccine: Inhibition by Immunization ofRecipients with Host Antigen. J. LINDENMANN.............................. 883

Immunological Unresponsiveness Induced by Cryptococcal Capsular PolysaccharideAssayed by the Hemolytic Plaque Technique. JUNEANN W. MURPHY AND GEORGEC. COZAD............................................................... 896

Rabies Antibody Determination by Immunofluorescence in Tissue Culture. JOHN G.DEBBIE, JEROME A. ANDRULONIS, AND MELVIN K. ABELSETH ..... ................ 902

Further Characterization of a Factor from Endotoxin-Treated Serum which ReleasesHistamine and Heparin from Mast Cells. WILLIAM A. HOOK, RALPH SNYDERMAN,AND STEPHAN E. MERGENHAGEN............................................ 909

Alteration in Antibody Response Induced by Carbon Inhalation: a Model System.A. ZARKOWER AND W. MORGES....................... ......................915

Ribosomal Vaccines. I. Immunogenicity of Ribosomal Fractions Isolated from Sal-monella typhimurium and Yersinia pestis. WILLIAM JOHNSON.................. 947

Isolation of the Outer Sheath of Leptospira and Its Immunogenic Properties in Ham-sters. N. E. AURAN, R. C. JOHNSON, AND D. M. RITZI....................... 968

Anti-Teichoic Acid Antibodies and Non-treponemal Serological Tests for Syphilis.A. J. WICKEN, JANET W. GIBBENS, AND K. W. KNOX.......................... 982

Cryoprotein Produced by Clostridium botulinum Type G. ALBERTO S. CICCARELLI ANDDOMINGO F. GIMENEZ.................................................... 985

Effect of Vitamin E on the Immune Response of Hypoxic and Normal Chickens.ROBERT P. TENGERDY, ROLLIN H. HEINZERLING, AND CHERYL F. NOCKELS....... 987

xxii CONTENTS