INFORMATION FOR AUTHORS

Submission of Manuscripts Manuscripts are considered for publication in Human Pathology provided

that they have never been published and are not under simultaneous review by another journal. All manuscripts should be submitted electronically to http://ees.elsevier.com/yhupa. Authors will be guided stepwise through article type, title, authors, abstract, keywords, classifications, and uploading of the files, which should be labeled with appropriate and descriptive file names (eg, AuthorText.docx, AuthorTable3.docx, AuthorFig1.eps). Please note that even though manuscript source files are automatically converted to a PDF file at submission for the review process, these source files are needed for further processing after acceptance. There are no page charges for publication, although authors may choose to sponsor an article for Open Access at a charge of $3000 (see http://www.elsevier.com/wps/find/authorsview.authors/sponsoredarticles).

Authors with circumstances that prevent online submission (except those from the UK and Western Europe) should send their manuscripts electronically to Chris Reyes, Managing Editor, cmreyes@wisc.edu. Additional contact information for inquiries: Tel: 608-262-1868; Department of Pathology and Laboratory Medicine, University of Wisconsin–Madison, 1300 University Ave., 521 SMI, Madison, WI 53706-1510, USA.

Manuscript submissions from the UK and Western Europe should be addressed to Vincenzo Eusebi, MD, European Editor, Vincenzo.Eusebi@ausl.bo.it. Additional contact information for inquiries: Tel: +39 051 6225750; Universita Bologna, Servizio Anatomia Patologica, Ospedale Bellaria, Via Altura 3, Bologna, Italy 40139.

Submissions should conform to Elsevier’s ethics policies (see http://www.elsevier.com/wps/find/authorsview.authors/rights), including statements regarding human and animal subjects and written permissions for borrowed material as appropriate. Additional information can be found at http://www.ethics.elsevier.com/. Only after a manuscript is accepted for publication should the corresponding author download and complete—including the signatures of all coauthors in section II—the Ethics and Financial Conflict form located at http://ees.elsevier.com/yhupa/img/Ethics_and_Financial_Conflict_Form.pdf.

Original Contributions should not exceed 12 pages of text, 30 pages total, including references, tables and figures. References should be limited to 35 and the abstract to 250 words. A maximum of 8 figures/tables will ordinarily suffice to illustrate key points. Manuscripts that exceed these limits, at the discretion of the editorial team, will be returned without review. The typical Original Contribution will be organized into Introduction, Materials and Methods, Results, Discussion, and possibly Conclusions/Concluding Remarks.

Case Studies must provide new information. Clinically significant observations based on new or developing technology will receive special consideration. Imaginative applications of established methods are also encouraged. Brevity is required: Case Studies must not be more than 12 pages, including references, tables, and figures. The following restrictions apply: 150-word abstract, 15 references, 3 figures. The Case History/Report should be included under Materials and Methods followed by a brief description of whatever tissue manipulations and/or immunologic and molecular techniques were employed. Authors should not provide a literature review.

Human Pathology encourages Letters to the Editor, which will be published at the discretion of the editor as space permits and are subject to editing and abridgment for length. Letters should be limited to approximately 500 words and 5 references maximum. Usually, only correspondence responding to items previously published in Human Pathology are considered for publication, and we typically invite the authors of the original item to submit a Reply to the Letter to the Editor.

Announcements of conferences and similar events of interest to the readership of Human Pathology should be sent to the Managing Editor at least 3 months before the first day of the month of desired publication.

Book Reviews, Current Topics, Editorials, Pathology Education, Perspectives in Pathology, and Progress in Pathology are published by invitation only. Submission Elements

Every submission must include a Letter of Submission that states that the manuscript, or parts of it, have not been and will not be submitted elsewhere for publication, and that all authors have read and approved the manuscript. Where digital or scanned signatures cannot be provided, authors may send a duplicate signed copy to the Editorial Office by fax or mail. Authors of original contributions and case studies are highly encouraged to include a list of three or more potential reviewers for their manuscript, with complete contact information including email address. Revised manuscripts should also be accompanied by a unique file (separate from the letter of submission) with responses to reviewers’ and editors’ comments. The manuscript should be a Microsoft Word (or compatible) file comprising title page, abstract (except announcements, correspondence, and book reviews), manuscript text, references, and table/figure legends. Authors should not embed figures, tables, or supplementary material into the manuscript file; these should be submitted separately. Standard Manuscript Form

Unless otherwise specified, the requirements of this journal are in accordance with the International Committee of Medical Journal Editors’ Uniform Requirements for Manuscripts Submitted to Biomedical Journals (Ann Intern Med1988;108:258-265; http://www.icmje.org/urm_main.html). The manuscript, including references and legends, should be typed double-spaced in 12 point font for all text (except superscripts or subscripts), and with page numbers (line numbers encouraged) and 1 inch (2.5 cm) left-justifi ed margins throughout. Each of the following sections should start on a new page: title page, abstract, main text, acknowledgments, references, and table/figure legends. The title page, in addition to the title, should include authors’ names and degrees; institutional and/or corporate affiliations including postal codes; up to 5-7 keywords; a running head that condenses the full title; conflict of interest and funding disclosures; and the complete contact information of the corresponding author. Authors are expected to disclose any commercial associations that might pose a conflict of interest in connection with the submitted manuscript; all funding sources supporting the work should be routinely acknowledged.

Unless otherwise noted, the style of Human Pathology follows AMA Manual of Style, 10th ed. (http://www.amamanualofstyle.com). Formatting, such as Greek letters, italics, super- and subscripts, may be used; such elements must be

consistently formatted throughout the manuscript, including tables and legends. Gene symbols should be italicized, whereas proteins are in Roman text. We encourage authors to follow HUGO (http://www.genenames.org/) and Universal Protein Resource nomenclature (http://www.uniprot.org/). Authors should avoid abbreviations in the title and minimize their use in the abstract and main text, particularly for diseases. All abbreviations should be defined the first time they appear in the abstract and text. Standard abbreviations that follow the Unified Medical Language System (https://uts.nlm.nih.gov/home.html) are preferred. Otherwise, a list of definitions for nonstandard abbreviations should be provided on a separate page following the abstract.

All manuscripts should be in grammatically correct, colloquial American English. Manuscripts that do not meet this requirement may be returned to the authors for editing. Non–English speaking authors are encouraged to consult native English speakers or English copy editors prior to submission. In some cases, manuscripts accepted for publication may be edited at the authors’ expense to comply with proper English usage. The Editorial Office reserves the right to revise the wording of manuscripts accepted for publication in the journal.

References should be arranged in order of citation and numbered consecutively. In-text citations should be formatted in the running text without superscript, enclosed in square brackets, and located to the left of punctuation. All references in the reference list must be cited in the text, and vice versa. If using EndNote (or comparable software) to format references, authors should remove field codes from the entire manuscript before submission because these automated features are lost in conversion during article layout. Otherwise, authors should simply type the reference number in square brackets in the text and manually type the reference list.

“Personal communications” and “unpublished observations” should be indicated within the text but excluded from the reference list. Information from manuscripts submitted but not yet accepted should be cited in the text as “unpublished observations.” For manuscripts that have been accepted for publication, authors should provide as much information as is currently available, including year and DOI if published online. Updates are appreciated once more information, such as volume and page numbers, becomes available. All author/editor names should be listed when fewer than 7; otherwise, insert “et al” after third name.

References to journals should include the following information in this order: the authors’ family names with initials, article title and subtitle, journal name as abbreviated in Index Medicus (http://www.ncbi.nlm.nih.gov/nlmcatalog?term=currentlyindexed[All]), year, volume number, and inclusive page numbers:

Kolonel LN, Nomura AMY, Hirohata T, Hankin JH, Hinds MW. Association of diet and place of birth with stomach cancer incidence in Hawaii Japanese and Caucasians. Am J Clin Nutr 1981;34:2478-85. In book citations, authors should provide, when appropriate, the chapter

authors’ names and the chapter title along with the book editors’ names, the title and edition, the place of publication, publisher, year, and inclusive page numbers:

Kolonel LN, Hinds MW, Hankin JH. Cancer patterns among migrant and native born Japanese in Hawaii in relation to smoking, drinking, and dietary habits. In: Gelboin HV, MacMahon B, Matsushima T, eds. Genetic and environmental factors in experimental and human cancer. Tokyo, Japan: Science Society Press; 1980. p. 327-40.For online sources such as databases, the reference format should follow

that specified by the Website, if available. Otherwise, references should include individual or institutional author names, title, version number or most recent update, publisher/sponsor, access date, and URL:

Distribution of somatic mutation in KRAS. COSMIC Database v57, release date 18Jan12, Sanger Institute. http://www.sanger.ac.uk/perl/geneticsCGP/cosmic/. Accessed 28 Feb 2012.All tables, figures, and supplementary materials should be cited in the text

and numbered in the order that they are cited. When uploading each figure/table, authors should include the appropriate label number in the description field, so that it can be readily identified in the PDF during review. Only files intended for online publication should be identified as supplementary.

Tables should be formatted as Word or Excel (or compatible) tables. Each table should have a brief descriptive legend. Column headers and row stubs should also be brief, and data should be decimal or left aligned as appropriate. All abbreviations should be defined in a single footnote that begins with “Abbreviations:” and should be arranged either alphabetically or in order of appearance. Superscript lower-case letters should be used to denote additional footnotes, and asterisks or footnote letters for statistically significant data instead of values in bold. Only files intended for online publication should be identified as supplementary.

Figures should be submitted as individual high resolution graphics files in EPS or TIF format when possible. Art should be created with graphics software such as Photoshop or Illustrator, not presentation software such as PowerPoint, CorelDraw, or Harvard Graphics. Color images must be CMYK, with minimum resolution of 300 DPI for photos and at least 1200 DPI for line art (eg, graphs, flow charts, schema). Instructions for electronic artwork submission are available at http://www.elsevier.com/wps/find/authors.authors/authorartworkinstructions.

Ideally, individual panels of a given figure are arranged in the order they are cited in the text and labeled as a single alphabetical series. Labels should appear as capital letters without background shape. The legend for each figure should describe the panels in alphabetical order. It is not necessary to assign labels to panels in the figure if they are not cited and discussed individually in the text and legend. Where appropriate, authors should include information on staining and magnification, as well as any abbreviations or objects such as arrows that appear in the image.

Color art charges apply for the print edition: $650 for the first color figure and $100 for each additional color figure. Color figures should be clearly marked as being intended for color or black and white reproduction in print; art is reproduced in color on the Web free of charge. Higher contrast images are suggested for black and white reproduction in print.

Supplementary materials should be labeled and cited in the text (eg, Supplementary Table S1, Supplementary Fig. S1) and should follow the appropriate format requirements. A link to their online location will be included at the end of the main text during layout. Supplementary materials are posted online as is without editing or layout.