Roche Connect

Administrator

F. Hoffmann- La Roche AG Division Pharma

Roche Connect

MSHSOS

Bau/Raum 657/24.013

Tel. 061 688 5566

switzerland.rocheconnect@roche.com

Information on Roche Connect.

Roche Connect is a worldwide plan that Roche employees can choose to join. It gives you a way to invest in

the future and share financially in the success of Roche by purchasing Roche Genussscheine (non-voting

equity securities) at a 20% discount.

You are eligible to enrol in Roche Connect three months after you start working at Roche. Please note that

enrolment is only possible immediately after this three-month waiting period (in your 4th month of

employment only). After this time, you must wait until the next annual open enrolment period. This is

generally a three-week period from April to May.

Before you decide to enrol in Roche Connect, we ask you to read through the following documents:

- Roche Connect Leaflet

- Tax information regarding Roche Connect

If you decide to participate in Roche Connect, we ask you to sign and send the Application Form to your

local Roche Connect Administrator:

- By internal mail: B. 657 / R. 24.013

- By email: switzerland.rocheconnect@roche.com

For more information, please visit:

http://connect.roche.com/ch-en/ch-home

Please don’t hesitate to contact us if you have any questions.

Kind regards

Roche Connect Administrator Switzerland

February 2016

F. Hoffmann-La Roche Ltd Group Human Resources CH-4070 Basel, Switzerland connect.roche.com

If you have any questions about Roche Connect, please contact your local Roche Connect Administrator.

Things to consider

Before investing in Roche Connect, it is important to consider:

• How much you can afford to invest and if you want to invest in shares or securities and, in particular, Roche Genussscheine

• How long you can afford to be without the money you have invested

• Whether or not you can commit to contribute for the whole Plan Year

• Your attitude towards risk, as the value of Roche Genussscheine may fall as well as rise and exchange rate movement may affect the value of your holding.

Investing is very much a personal decision and you need to decide what is right for your situation. With so many other investments to choose from, you may wish to talk to an independent financial adviser. Please note that neither the Company nor any of its employees or representatives may provide you with financial advice.

Taxation

Roche Connect is designed to be as tax effective as possible. However, you may be liable for taxes on the amount of the discount applied to the price of the Genussscheine you purchased, on any gains, and on any dividends that you receive.

Roche will not meet any tax liability on your behalf and reserves the right to withhold these taxes from your salary where required by local law. Please refer to the Tax Fact Sheets on connect.roche.com for further information. You may also wish to consult your tax adviser for further guidance.

Termination of employment

In most of the countries, all of the Roche Genussscheine you have bought are made available to you upon termination of your employment, including those you have held for less than the full length of the holding period. For tax reasons, different rules apply for Swiss retirees and all Belgian participants. Please ask your local Roche Connect Administrator for details or visit our website connect.roche.com.

Roche Connect

Make the Connection.Share in the Success.

An important note

This guide provides a summary of the Roche Genussscheine Purchase Plan, also known as Roche Connect. The Plan is governed by detailed Regulations that will prevail in the event of a discrepancy with this guide. Copies of the Regulations may be obtained from your local Roche Connect Administrator.

The investment offering described in this document is made to you as an employee of Roche by your local employing company. This offering does not change or supplement, in any way, the terms of your employment or create any employment rights. You are not required to participate in this offering. Your decision to participate or not is entirely up to you. Your choice will have no impact on your employment or your career. Participation in the Plan does not confer upon any Participant any legal right to continue to be employed by Roche, regardless of the length of time the Participant has been granted benefits under the Plan. This document does not constitute an employee handbook or an employment contract between you and any Roche company.

We recommend that you seek independent financial advice when deciding whether or not to participate in Roche Connect or any other investment.

Roche reserves the right to suspend, change, amend or supplement the terms of this offering, in whole or in part, for any reason at any time.

Securities offered outside the United States of America have not been registered with the Securities and Exchange Commission and may not be resold in the US unless registered or unless an exemption from registration is available.

The offer to which this document pertains (the “Offer”) is being made under the Roche Connect Plan. Roche has prepared a prospectus (the “Prospectus”) in relation to the Offer which contains full details of the Roche Connect Plan, together with information about Roche and the Genussscheine being offered under the Roche Connect Plan. The Prospectus has been prepared in English and is available, together with a summary that has been translated into certain local languages, on the Roche intranet (connect.roche.com) and at Roche’s headquarters at 4070, Basel, Switzerland. Alternatively, if you are in an EU participating country and you wish to receive a paper copy of the Prospectus and, where applicable, the summary in a local language, please contact your local Roche Connect administrator.

The holding period

In most of the countries, Roche requires participants in the Plan to hold their Genussscheine for three years. This period is known as the holding period and reflects the goal of the Plan to encourage long-term employee identification with the interests of Roche.

In order to make the Plan more tax advantageous for the respective employees, the holding period is four years for all Swiss participants. In Austria, the holding period finishes at the end of the 5th calendar year after the Genussscheine were allocated.

Follow your investment

Our plan administrator provides Roche Connect participants with details on how toaccess a web site where they canview account information, checkthe daily price of Genussscheineand enter transactions.

You will also receive regular statements from the plan administrator showing recent transactions, as well as the value of the balance of your Plan account.

What is Roche Connect?

Roche Connect is a world-wide plan that Roche employees can choose to join. It gives you a way to invest for the future and share financially in the success of Roche by purchasing Roche Genussscheine.

The great thing about Roche Connect is that in most countries Genussscheine are available for you at a discount of 20% relative to market value. In Chile, Canada and India, you purchase the Genussscheine at market value, but you receive a cash bonus of 20% of the amount you invest in Roche Connect. You purchase these Genussscheine with your own money.

Each year, you choose how much to invest in your local currency. This annual election remains in place until the next Open Enrollment period. At this point, you can choose whether to alter your contribution, or to stop contributing for the following year. If you do not make any changes, your contribution level will automatically continue.

The Plan not only helps ‘connect’ employees to our business, but also links personal investments to the Company. This way, you can benefit from any growth in the price of Genussscheine as a result of our strategy to be a leading independent healthcare company.

How does it work?

Who can join?

What else is important?

When can I join?

Roche Connect is offered in a number of countries around the world.

Although details vary slightly from country to country for tax and legal reasons, where we offer the Plan, all permanent Roche employees, including part-time employees, can join Roche Connect.

The Plan is voluntary: you choose whether or not you want to join and how much you want to contribute.

Employees can join the Plan at one of three points:

• When the Plan is first launched in their country

• When they start working for Roche (if hired after the initial launch)

• During the annual Open Enrollment periods for the Plan (usually each April / May).

Enrollment First contribution

First purchase of Genussscheine

Next Open Enrollment period

April to May June July April to May

The purpose of this guide is to give you an overview of the most important aspects of Roche Connect. If you have any questions, check our website connect.roche.com or contact your local Roche Connect Administrator.

Here’s a quick look at how the Plan works:

A. You decide if you want to join Roche Connect and, if you do, how much you want to contribute. You can contribute between 0.5% and 10% (0.625% to 12.5% in Canada and India) of your annual gross base salary.

B. Enroll and set the amount of your total annual contributions by completing and returning your Roche Connect enrollment form to your local Roche Connect Administrator.

C. You make monthly contributions to Roche Connect. In almost all countries, payroll deducts the respective amounts directly from your salary.

D. Every month, the contributions are used to buy Roche Genussscheine. Those Genussscheine are then held in your personal Roche Connect account.

E. You decide, each year, whether to change your contributions or to stop contributing to Roche Connect for the following year.

F. After retaining them for the holding period (three to five years depending on the country in which you participate in Roche Connect) you are free to keep or sell your Genussscheine.

It’s that simple!

What are Genussscheine?

Roche offers investors two ways to invest: through regular voting shares and also through non-voting equity securities (Genussscheine).

Genussscheine are by far the most common securities traded in Roche. Unlike the regular shares, the Genussscheine do not carry voting rights, but in all other respects they confer the same ownership and dividend rights as the regular shares.

After the holding period

At the end of the holding period, you may choose to:

• Keep your Genussscheine

• Sell your Genussscheine

• Transfer them from the Plan to an individual brokerage account (varies in certain countries, not possible for example in India, Brazil, Pakistan and China).

You are responsible for paying transaction fees arising from your sale/transfer of Genussscheine. Also, be sure to consider the potential tax liability. Select your country on connect.roche.com and go to section “Questions & Answers” for detailed information on transaction costs. You also find there a Roche Connect User Guide explaining how you can sell or transfer your Genussscheine and a country tax fact sheet.

Février 2016

F. Hoffmann-La Roche SA Group Human Resources CH-4070 Bâle, Suisse connect.roche.com

Si vous avez des questions sur Roche Connect, veuillez contacter l’administrateur local de Roche Connect.

Ce que vous devez considérer

Il est important de considérer les points suivants avant d’investir dans Roche Connect:

• combien d’argent vous pouvez vous permettre de placer et si vous préférez des actions ou d’autres titres, en particulier des bons de jouissance

• le temps pendant lequel vous pouvez vous passer de l’argent que vous avez placé

• si vous pouvez vous permettre de vous engager pour une année entière

• le fait que le bon de jouissance Roche peut aussi bien perdre de la valeur qu’en prendre et que votre avoir est à la merci des fluctuations du taux de change

Placer de l’argent est une décision très personnelle, que vous devez prendre en tenant compte de votre situation. Les possibilités de placement étant multiples, il serait peut-être sage de prendre l’avis d’un conseiller financier indépendant avant de décider quoi que ce soit. Veuillez noter que ni l’entreprise ni aucun de ses employés ou représentants ne peut vous conseiller en matière financière.

Impôts

Roche Connect a été conçu de façon à ce que vous payiez le moins d’impôts possible. Il se peut toutefois que le rabais dont vous bénéficiez sur l’achat des bons de jouissance, les gains que vous réaliserez ou les dividendes que vous toucherez soient imposables.

Roche ne prendra vis-à-vis de vous aucun engagement fiscal et se réserve de déduire de votre salaire les impôts dus au titre de Roche Connect si la loi du pays le requiert. Pour plus de détails, veuillez vous référer aux mémentos fiscaux (tax fact sheets) se trouvant sur connect.roche.com Envisagez également de consulter à ce sujet votre conseiller fiscal.

Cessation des rapports de travail

Dans la plupart des pays, l’employé dont cessent les rapports de travail récupère la totalité des bons de jouissance qu’il a achetés, y compris ceux pour lesquels la période de détention n’est pas encore entièrement écoulée. Pour des raisons fiscales, les règles sont différentes pour les pensionnés suisses et tous les participants belges. Veuillez contacter l’administrateur local de Roche Connect ou vous rendre sur le site connect.roche.com pour de plus amples détails.

Roche Connect

Connectez-vous.Prenez votre part du succès.

Notice importante

Cette brochure donne un aperçu général du plan d’achat de bons de jouissance Roche appelé Roche Connect. Ce plan fait l’objet d’un règlement détaillé qui fera foi en cas de divergence avec le présent texte. Vous pouvez vous procurer le règlement auprès de l’administrateur local de Roche Connect.

L’offre de placement décrite dans ce document vous est faite en tant qu’employé par la société Roche qui est votre employeur. Elle ne modifie ni ne complète en rien les termes de votre contrat de travail, pas plus qu’elle ne crée de droits d’emploi. Vous n’avez aucune obligation de l’accepter. Vous décidez vous-même, en toute liberté, de participer ou non au plan. Le choix que vous ferez n’aura aucun impact sur votre emploi ou votre carrière. Quel que soit le nombre d’années pendant lesquelles un participant a bénéficié de prestations au titre du plan, celui-ci ne lui confère aucune prétention fondée en droit à continuer d’être employé par Roche. Le présent document n’est ni un manuel d’employé ni un contrat de travail entre vous et une quelconque société Roche.

Nous vous recommandons de ne pas adhérer à Roche Connect, ni à aucun autre véhicule de placement, sans avoir pris l’avis d’un professionnel indépendant.

Roche peut à tout moment, et pour quelque motif que ce soit, suspendre, modifier ou compléter tout ou partie des termes de la présente offre.

Les titres proposés en dehors des Etats-Unis d’Amérique n’ont pas été enregistrés par la «Securities and Exchange Commission» ils ne peuvent donc pas être revendus aux Etats-Unis sans avoir été enregistrés ou que soit produite une preuve d’exemption de l’obligation d’enregistrer.

L’offre à laquelle se rattache le présent document (l’«offre») est faite dans le cadre du plan Roche Connect. Roche a réalisé en rapport avec cette offre un prospectus (le «prospectus») contenant tous les détails du plan Roche Connect, ainsi que des informations sur Roche et les bons de jouissance proposés sous Roche Connect. Le prospectus a été rédigé en anglais; il est disponible, ainsi qu’un résumé traduit en plusieurs langues, sur l’intranet de Roche (connect.roche.com) ainsi qu’au siège social de Roche, 4700 Bâle, Suisse. Les participants de l’UE peuvent également obtenir une copie papier du prospectus, ainsi qu’un résumé de celui-ci s’il existe dans leur langue, en contactant l’administrateur local de Roche Connect.

Qu’est-ce que Roche Connect?

Lancé à l’échelle mondiale, Roche Connect est un programme donnant aux employés de Roche la possibilité de faire un placement pour l’avenir et de participer au succès financier de l’entreprise en achetant des bons de jouissance Roche.

Ce qui est formidable avec Roche Connect, c’est que vous bénéficiez, dans la plupart des pays, d’un rabais de 20% pour l’achat des bons de jouissance. Au Chili et au Canada, les bons de jouissance s’achètent au prix du marché, mais Roche accorde, en contrepartie, une remise en espèces de 20% sur la somme investie. Vous payez vos bons de jouissance avec votre propre argent.

Vous décidez chaque année du montant de votre placement en monnaie locale, qui reste valable jusqu’à la période d’inscription de l’année suivante. Vous avez alors la possibilité de modifier votre contribution ou d’y mettre fin. Si vous ne faites rien, votre niveau de contribution restera automatiquement le même pour l’année qui suit.

Ce plan est un moyen de «connecter» les collaborateurs à l’entreprise mais aussi de rattacher à celle-ci votre investissement personnel et de profiter ainsi de toute augmentation du prix des bons de jouissance résultant de notre détermination à être une entreprise leader du domaine de la santé.

Comment cela fonctionne-t-il?

Qui peut participer?

Autres points importants

Quand peut-on s’inscrire?

Roche Connect existe dans de nombreux pays, à des conditions dont les détails peuvent varier légèrement pour des raisons fiscales et juridiques.

La participation est ouverte à tous les employés permanents de Roche, y compris ceux qui travaillent à temps partiel.

Le plan est facultatif: vous décidez vous-même d’adhérer et fixez vous-même le montant de votre participation.

L’inscription peut se faire à trois moments:

• lorsque le plan est lancé dans un pays

• à l’entrée chez Roche (si le plan est en vigueur dans le pays)

• lors de la période annuelle d’inscription (généralement avril-mai)

Inscription 1ère contribution

Premier achat de bons de jouissance

Période d’inscription suivante

avril-mai juin juillet avril-mai

Le but de cette brochure est de vous renseigner sur les aspects les plus importants de Roche Connect. Si vous avez des questions à ce sujet, veuillez consulter notre site web connect.roche.com ou vous adresser à l’administrateur local de Roche Connect.

Voici, en quelques points, comment fonctionne le plan:

A. C’est vous qui décidez de participer à Roche Connect et fixez, si vous adhérez, le montant de votre contribution: entre 0,5% et 10% de votre salaire de base annuel brut (0,625% à 12,5% au Canada).

B. Il suffit pour adhérer à Roche Connect de fixer le montant annuel de votre contribution, de compléter le formulaire d’inscription et de le retourner à l’administrateur local de Roche Connect.

C. Les contributions à Roche Connect sont mensuelles. Dans presque tous les pays, elles sont déduites directement du salaire.

D. Les contributions mensuelles sont utilisées par l’administrateur du plan pour acheter les bons de jouissance Roche. Ces bons de jouissance sont crédités sur votre compte Roche Connect personnel.

E. Vous avez chaque année la possibilité de modifier votre contribution ou d’y mettre fin pour l’année suivante.

F. Passé une période de détention de trois à cinq ans, selon le pays où vous êtes inscrit, vous pouvez soit conserver soit vendre vos bons de jouissance.

C’est aussi simple que ça!

La période de détention

Dans la plupart des pays, Roche exige des participants qu’ils conservent leurs bons de jouissance pendant trois ans. Cette période, dite de détention, reflète la volonté de créer à travers le plan une identification durable avec les intérêts de Roche.

Pour les employés suisses, la période de détention est de quatre ans, ceci parce que les participants bénéficient alors de conditions fiscales plus avantageuses. En Autriche, la période de détention s’achève à la fin de la 5e année civile qui suit l’attribution des bons de jouissance.

Après la période de détention

La période de détention terminée, vous pouvez:

• conserver les bons de jouissance

• vendre les bons de jouissance

• les transférer du plan sur un compte de courtage personnel (varie dans certains pays, pas possible en Inde, au Brésil et en Chine, par exemple).

Des frais seront perçus pour la vente ou le transfert de bons de jouissance. Ne vendez pas non plus sans vous être renseigné sur une possible imposition du produit de la vente. Sélectionnez votre pays sur connect.roche.com, puis allez à la rubrique «Questions & Réponses» où vous trouverez des informations détaillées ayant trait aux frais de transaction. Vous y trouverez également un Guide de l’Utilisateur Roche Connect qui vous expliquera comment vous pouvez vendre ou transférer vos bons de jouissance et un mémento fiscal (tax fact sheet) de votre pays.

Suivez votre placement

Qui administre le plan, vous expliquera comment accéder au site Internet sur lequel vous pourrez consulter votre compte, suivre l’évolution du prix des bons de jouissance et entrer les transactions. Vous recevrez régulièrement d’UBS des relevés vous informant des transactions récentes ainsi que du solde de votre compte Roche Connect.

Qu’est-ce qu’un bon de jouissance?

Il existe deux types de titres: l’action, qui confère un droit de vote, et le bon de jouissance, qui n’en confère pas mais donne, sinon, les mêmes droits de propriété et de dividende que l’action. Le bon de jouissance est le titre Roche de loin le plus répandu.

Roche Connect Make the connection – share in the success

Employee Tax Fact Sheet

Please bear in mind that the comments made below are for your guidance only. Your individual circumstances will have a significant impact on your liability to tax and social security. This guidance assumes you are a resident for tax purposes in Switzerland. Please refer to the following pages if you are either a French or German cross-border commuter.

The rules governing the tax and legal treatment of the Roche Genussscheine Purchase Plan (“Roche Connect”) are subject to change. The detail given here reflects our understanding of the position in Switzerland as of 1 January 2016.

A) Personal Taxation

At what point in time will the local authorities seek to tax my Genussscheine (GS) purchased under “Roche Connect”?

The discount applied to the GS purchased under “Roche Connect” is not considered employment income because of the four-year blocking period. Therefore the Swiss tax authorities will only require you to pay income tax on the value of the discount in cases of premature unblocking (see below).

Any private capital gains realised upon the sale of the GS are tax-free.

How will my dividends be taxed?

Any dividend you receive from your holding of Roche GS is taxed as investment income, subject to Swiss income tax at your personal marginal rate.

Do I have to pay any taxes when leaving Roche prior to the expiry of the four-year blocking period of the GS?

Yes. Your GS will immediately be unblocked when leaving Roche. Due to this premature unblocking of the GS a pecuniary benefit will be calculated by taking into consideration the reduced blocking period and the market value of the GS at the time of the premature unblocking.

B) Social Security

Do I have to pay any social security on the purchase or sale of the GS?

As no taxable employment income is realised when purchasing the GS, no social security contributions will be due at this point in time. However, when leaving Roche prior to the expiry of the four-year blocking period, the pecuniary benefit calculated at the time of the premature unblocking will be subject to social security.

C) Other

Will any other taxes be payable e.g. wealth tax?

Yes. GS held at 31 December are subject to annual wealth tax on the value of the GS as published by the Swiss Federal Tax authorities. Blocked portions of the GS may be discounted (depending on the applicable cantonal tax law) for wealth tax purposes.

What documents do Switzerland’s tax and/or legal authorities require the employer to be issued to me, detailing the purchases and/or sale?

Your employer is required to provide you with an annual salary certificate. In addition, Equatex will provide you with your “Roche Connect Plan” account statements quarterly. For your annual tax declaration you need the account statement with the dividends, the Roche Connect Statement Qu 4 of the tax year as well as the Wealth Tax Statement. German and French cross-border commuters will receive an addendum to their salary statement. You have to enclose these documents to your annual tax declaration.

Example of what happens if non-voting equity securities are unlocked prematurely

If an employee leaves Roche before the end of the four-year holding period, the pecuniary benefit is calculated anew. Accordingly, the original 20% price discount financed by Roche has consequences for the employee because the earned income that arises from the reduced blocking period is subject to income tax and social security deductions at the time the Genussscheine (GS) are unblocked.

Roche will prepare a calculation similar to the one below to determine the taxable earned income resulting from the premature unblocking of the GS. This amount will then be shown (gross) in the employee's annual salary statement.

Example:

The stock market price of the employee's GS was CHF 165.20 on the date they were acquired (e.g. on 18 January 2012). To ensure that this 20% discount on the purchase price remains exempt from income tax and social security contributions, the GS have to remain blocked up until January 2016. The situation at the outset is thus as follows:

Stock market price of the GS at the date of purchase on 18 January 2012: CHF - 165.20

Purchase price (80 % of the stock market price) CHF - 132.15

Pecuniary benefit (CHF 165.20. /. CHF 132.15) CHF - 033.05

Tax discount for the four-year blocking period = 20% (CHF 165.20 * 20%) CHF - 033.05

Taxable pecuniary benefit arising from compliance with 4-year blocking period CHF - 00.00

The employee now decides to leave Roche in October 2014.

Premature termination of the blocking period is 2 years and 9 months

after purchase of the GS.

Stock market price of the GS At the date of the premature unblocking (assumption) CHF - 205.00

Time remaining until the full blocking period: 1 year and 3 months

Legal formula value * for 1 year and 3 months: 92.98% (CHF 205.00 * 92.98%) CHF - 190.60

Taxable gross employment income at the time of the premature unblocking

per GS (CHF 205.00 ./. CHF 190.60) CHF - 14.40

A similar calculation will be prepared for all other GS purchased in the last four years, determining the pecuniary benefit resulting from the reduced blocking period for every month of the blocking period. There is no premature unblocking provision for the GS purchased four or more years before the employee’s departure date. There is therefore no additional pecuniary benefit for these GS, and so no additional income tax.

*Legal formula used to determine the additional pecuniary benefit for the chosen point in time:

Years

until the

end of

the

blocking

period

3.5

3

2.5

2

1.5

1.25

1

0.5

Formula

value

81.55%

83.96%

86.44%

89.00%

91.63%

92.98%

94.34%

97.13%

Roche Connect Make the connection – share in the success

Employee Tax Fact Sheet German cross-border commuters

This summary outlines the general tax and social security implications for German cross-border commuters of Roche who participate in Roche Connect. All employees who reside in Germany but work in Switzerland and return regularly home to Germany after work are considered German cross-border commuters.

This summary is provided for informational purposes only and should not be relied upon as being either complete or conclusive. The tax consequences included below are in accordance with Swiss tax and social security law and practices as of 1 January 2016. These laws and practices may change over time.

GERNERAL TAXATION OF GERMAN CROSS-BORDER COMMUTERS

In principle, the employment income of German cross-border commuters is taxable in Germany. According to the double tax treaty between Switzerland and Germany, Switzerland has the right to withhold tax of 4.5% on the gross employment income earned in Switzerland. Your Swiss employer will deduct this preferential Swiss withholding tax from employment income only if you have filed an official confirmation of German residence with your Swiss employer (otherwise Swiss tax is withhold at a full rate).

In general, the employment income of German cross-border commuters in Switzerland is subject to Swiss social security charges provided the commuters are EU or EFTA citizens who are employed solely in Switzerland.

UPON THE PURCHASE OF THE GENUSSSCHEINE

Switzerland

When participating in Roche Connect, employees may purchase Genussscheine at a discount equal to 20% of the reference price. The difference between the purchase price and the reference price (i.e. the discount of 20%) is considered employment income subject to Swiss income tax. However, since the Genussscheine are blocked for 4 full years from the purchase date, the Swiss authorities grant a tax discount in the range of 20%. Since the tax discount equalizes at least the discount on the reference price, no taxable employment income should be realized upon the purchase of the Genussscheine under Roche Connect.

Since social security charges generally follow direct federal taxes (taxable amount and moment), no Swiss social security liability will arise upon the purchase of the Genussscheine.

In case of early deblocking of the Genussscheine in the event of termination of employment, additional gross employment income arises, which is subject to income tax and social security liabilities at the date of deblocking.

Germany

The tax discount granted in Switzerland is not applicable for German tax purposes. The difference between the purchase price and the reference price (i.e. the 20% discount on the reference price) is considered employment income subject to German income tax. You must declare this employment income to the German tax authorities for income tax purposes.

UPON THE SALE OF GENUSSSCHEINE

Switzerland

No tax liability will arise upon the sale of the Genussscheine.

Germany

Purchase of Genussscheine after December 31, 2008:

Capital gains from sale of Genussscheine is taxable with a flat rate of 25% income tax plus 5.5% solidarity surcharge and if applicable 8-9% church tax - irrespective of the holding period. There is an exemption of EUR 801 (EUR 1,602 for married couples filing jointly) available for all capital income received in one year. In case the capital gains exceed the tax-exempted amount the amount has to be declared in the income tax return (Anlage KAP).

Purchase of Genussscheine before January 01, 2009:

If the Genussscheine are held more than 12 months, the capital gain realised upon sale will be tax exempt (unless you owned at least 1% of the company’s nominal shares during the 5 years immediately preceding the sale). Since the Genussscheine purchased under Roche Connect are subject to a four-year blocking period, generally no capital gain tax should be due.

TAXATION OF DIVIDEND PAYMENTS

Switzerland

Dividends paid to you in cash or directly reinvested in additional Genussscheine are subject to Swiss withholding tax of 35%. However, based on the double tax treaty between Switzerland and Germany, such withholding tax may be reduced to a rate of 30%, provided you timely file the relevant forms.

Germany

Dividends are taxable with a flat rate of 25% income tax plus 5.5% solidarity surcharge and if applicable 8-9% church tax, if all capital income exceed the tax-exempted amount of EUR 801 (or EUR 1,602 for married couples filing jointly).

You may claim a tax credit against your German income tax payable for any Swiss dividend tax withholding deducted at source (max. 15%).

WEALTH TAX

Switzerland

German cross-border commuters are not subject to Swiss wealth tax.

Germany

There is no wealth tax in Germany.

Roche Connect Make the connection – share in the success

Employee Tax Fact Sheet French cross-border commuters

This summary outlines the general tax and social security implications for French cross-border commuters of Roche who participate in Roche Connect. All employees who reside in France but work in the border zone of Switzerland and return regularly home to France after work are considered French cross-border commuters.

This summary is provided for informational purposes only and should not be relied upon as being either complete or conclusive. The tax consequences included below are in accordance with Swiss tax and social security law and practices as of January 1, 2016. These laws and practices may change over time.

GENERAL TAXATION OF FRENCH CROSS-BORDER COMMUTERS

In principle, the employment income of French cross-border commuter is taxable in France. According to the agreement between France and some Swiss cantons (Bern, Solothurn, Basel-Stadt, Basel-Landschaft, Waadt, Wallis, Neuenburg and Jura), France will pay financial compensation of 4.5% of the annual gross employment income of all French cross-border commuters to the canton where they work. Therefore, Swiss tax will not be deducted from employment income.

For cantons which have not signed the above-mentioned agreement the following rules are applicable: The gross employment income of cross border commuters working in these cantons is subject to Swiss wage tax withholding. However, the French cross border commuter may take a credit on their French tax return in application of the double tax treaty between France and Switzerland (signed on September 9, 1966). This credit is equal to the French tax which would be due on the employment income taxed in Switzerland.

SOCIAL SECURITY REGIME APPLICABLE TO FRENCH CROSS-BORDER COMMUTERS

Employees who reside in France but work in the border zone of Switzerland are in principle subject to the Swiss social security system, including health insurance. They benefit from a health care coverage in France as if they were affiliated to the French social security system.

However, cross-border commuters who reside in France can be exempt from the Swiss health insurance system and choose as an alternative the affiliation to the French health insurance system (“Couverture Maladie Universelle – CMU”) by joining the CPAM they depend on based on their tax residency. The cross-border commuters will therefore be subject to a specific contribution of 8 % (new rate applicable since January 1, 2016) of their reference fiscal revenue “revenu fiscal de référence” Y-2 (i.e. 2014 for 2016) after a flat rebate of € 9,611 which is doubled should both taxpayers be cross-borders and no CSG- CRDS contributions are due.

In case the necessary information are not provided, the French social authorities will compute the social contributions due based on five times the French annual social security cap (i.e. € 193,080 for 2016). In case the information are provided late and a regularization is made, an increase of 10% will be applied on the taxable basis.

The choice of the health insurance regime, either in the country of residence (France) or in the country where the professional activity is performed (Switzerland), is not revocable and shall remain in force, except if the cross-border’s situation changes (new professional activity in Switzerland after a period of unemployment, repatriation to France, switch of status from employee to retired person).

UPON THE PURCHASE OF THE GENUSSSCHEINE

Switzerland

The difference between the purchase price and the reference price (i.e. the discount equal to 20% of the reference price) is considered net employment income, and therefore, subject to tax withholding and Swiss social security charges. However, since the Genussscheine are blocked for 4 full years from the purchase date, the Swiss authorities grant a tax discount in the range of 20%. Given that the tax discount equalizes at least the discount on the reference price, no employment income arises upon the purchase of Genussscheine under Roche Connect, and therefore, no tax withholding and social security liability should arise.

In case of early deblocking of the Genussscheine in the event of termination of employment, additional gross employment income arises, which is subject to income tax and social security liabilities at the date of deblocking.

France

The tax discount granted in Switzerland is not applicable for French tax purposes. The difference between the purchase price and the reference price (i.e. the 20% discount) is considered employment income, and therefore, subject to French income tax. You must declare this employment income to the French tax authorities for income tax purposes.

UPON THE SALE OF GENUSSSCHEINE

Switzerland

No tax liability will arise upon the sale of the Genussscheine.

France

The difference between the sales price and the fair market value of the Genussscheine at acquisition date is subject to capital gain tax. For sale of shares as from January 1, 2013 capital gains are subject to income tax at progressive rates (marginal rate of 45%) and to social surtaxes at 15.5% (with 5.1% deductible from taxable income of the following year).

A rebate on the taxable gain will be available, depending on the number of years the shares were held: 50% for shares held between two and eight years and 65% for shares held for more than eight years. The holding period is counted from the date of purchase of shares and ends on the sale date. The rebate applies on the net gain once determined by allocating the losses on the gains.

This deduction is only applicable for income tax purposes and not for the social surtaxes.

Capital gains may also be subject to high income contribution (for unmarried individuals, the 3% applies on income between EUR 250,000 to EUR 500,000, and 4% on the excess / for married couples, the 3% rate applies on income between EUR 500,000 to EUR 1 million, and 4% on the excess). The high income contribution is calculated on 100% of the gain (the exemption depending on the holding period is not applicable).

TAXATION OF DIVIDEND PAYMENTS

Switzerland

Dividends paid to you in cash or directly reinvested in additional Genussscheine are subject to Swiss withholding tax of 35%. However, based on the double tax treaty between Switzerland and France, such withholding tax may be reduced to a rate of 15%, provided you timely file the relevant forms.

France

You must report in the dividend income French income tax return in the year dividends are received (e.g. dividend income received in 2015 must be reported in the 2015 French income tax return, to be filed in 2016). You may claim a tax credit against your French income tax payable for any Swiss dividend tax withholding provided by the tax treaty concluded between France and Switzerland (but only to the extent of your French tax liability on this dividend income).

WEALTH TAX

Switzerland

French cross-border commuters are not subject to Swiss wealth tax.

France

French cross-border commuters may be subject to French wealth tax.

Taxpayers with a net wealth above EUR 1.3 million on January 1 o f the tax year are subject to French wealth tax at progressive rates ranging between 0.5% and 1.5%, on net wealth (gross assets less deductible debts existing on January 1).

While net wealth under EUR 1.3 million remains exempt, once the threshold is reached, the progressive rates will apply to net wealth in excess of EUR 800,000.

Roche Connect Make the connection – share in the success

Incidences Fiscales de Roche Connect Pour les frontaliers français

La présente notice d'information présente les principales incidences, en matière fiscale et de cotisations sociales, de la participation à Roche Connect par les frontaliers français de Roche. Tous les salariés résidant en France, qui exercent une activité professionnelle dans la zone frontalière suisse et qui regagnent régulièrement leur domicile en France le soir, sont considérés comme frontaliers français.

La présente notice est d'ordre général et ne saurait avoir un caractère exhaustif ou définitif. Les incidences fiscales ci-après sont conformes à la législation fiscale et sur la sécurité sociale et à la pratique en vigueur en Suisse au 1 Janvier 2016. Ces lois et pratiques sont susceptibles de modification postérieurement à cette date.

RÉGIME FISCAL APPLICABLE AUX FRONTALIERS FRANÇAIS

Le revenu salarial des frontaliers en Suisse est imposable en France. Aux termes de l'accord conclu entre la France et certains cantons suisses

(Berne, Soleure, Bâle-Ville, Bâle-Campagne, Vaud, Valais, Neuchâtel et Jura),

la France reverse aux cantons employant des frontaliers français 4,5% de la rémunération brute annuelle versée à ces derniers. Ainsi aucun impôt suisse n'est prélevé à la source sur leurs salaires perçus en contrepartie de leur activité professionnelle en Suisse.

En revanche, les règles suivantes s'appliquent aux cantons qui n'ont pas signé l'accord en question. Le revenu salarial brut des frontaliers exerçant une activité professionnelle dans ces cantons est soumis à l'impôt suisse à la source sur les salaires. Cependant, les frontaliers français peuvent bénéficier d’un crédit sur les impôts français correspondants aux revenus d’activités lucratives soumis en Suisse en application de la convention fiscale en vigueur entre la France et la Suisse (convention signée le 9 septembre 1966). Le montant du crédit est égal au montant de l’impôt français dû.

RÉGIME DE SECURITE SOCIAL APPLICABLE AUX FRONTALIERS FRANÇAIS Les salariés qui résident en France mais qui travaillent en Suisse en qualité de frontaliers sont par principe soumis au régime de sécurité sociale suisse, pays dans lequel ils exercent leur activité professionnelle, y compris en matière de couverture maladie. Ils bénéficient ainsi de la prise en charge des soins dispensés en France comme s’ils étaient affiliés au régime français de sécurité sociale.

Toutefois, les travailleurs frontaliers qui résident en France peuvent être exemptés de l’affiliation au régime suisse d’assurance maladie et opter pour l’affiliation à la Couverture Maladie Universelle (CMU) en s’inscrivant à la CPAM de leur lieu de résidence. Les travailleurs qui choisissent l’affiliation à la CMU seront soumis à une cotisation spécifique de 8% (taux applicable depuis le 1er janvier 2016) de leur revenu fiscal de référence N-2 (soit de 2014 pour les cotisations de 2016) et après application d’un abattement forfaitaire de 9 611 €, lequel est doublé en cas d’un foyer fiscal constitué de deux frontaliers, mais ne seront pas assujettis à la CSG-CRDS. A défaut de communiquer ces informations, la cotisation maladie est calculée sur une base forfaitaire (taxation d’office) correspondant à cinq plafonds annuels de sécurité sociale, soit 193 080 € pour 2016. Une majoration de 10% sera appliquée sur la base cotisable en cas de communication tardive de ces informations.

La décision, selon laquelle il est choisi de s’assurer soit dans le pays de résidence soit dans le pays du lieu de l’activité professionnelle est définitive et reste en vigueur à vie, sauf en cas de nouveau fait générateur (prise ou reprise d’activité en Suisse après une période de chômage, installation en France, passage au statut de travailleur à celui de pensionné).

ACHAT DE BONS DE JOUISSANCE

Suisse La différence entre le prix d'achat et le prix de référence (par exemple la décote de 20% sur le prix de référence) est considérée comme revenu salarial net et, partant, soumise à l'impôt à la source et aux prélèvements sociaux. Or, comme les bons de jouissance sont bloqués pendant 4 ans à compter de la date d'achat, les autorités fiscales suisses accordent un abattement de 20%. L'abattement fiscal étant au moins égal à la décote appliquée sur le prix de référence, l'achat de bons de jouissance dans le cadre de Roche Connect ne génère aucun revenu salarial et, partant, ils sont exonérés de l'impôt à la source et des prélèvements sociaux. Le déblocage anticipé des bons de jouissance lié à la cessation des rapports de travail entraînera un supplément de revenu salarial brut qui sera soumis à l'impôt sur le revenu et aux prélèvements sociaux en Suisse à la date de déblocage. France

La décote fiscale accordée en Suisse n'est pas admise par le fisc français. La différence entre le prix d'achat et le prix de référence (par exemple la décote de 20% sur le prix de référence) est considérée comme revenu salarial net et soumise à l'impôt sur le revenu en France. Ce revenu salarial doit donc être déclaré au fisc français l’année de son encaissement.

VENTE DES BONS DE JOUISSANCE

Suisse

La vente des bons de jouissance fait l'objet d'une exonération fiscale.

France

La différence entre le prix de vente et la valeur de marché des bons de jouissance à la date d'achat est soumise à l'impôt sur les plus-values mobilières. Les plus-values de cession de valeurs mobilières réalisées à compter du 1er janvier 2013 sont soumises au barème progressif de l'impôt sur le revenu (taux marginal de 45%) et aux prélèvements sociaux de 15,5% (dont 5,1% est déductible du revenu imposable en N+1). Un abattement pour durée de détention peut être appliqué sur le montant du gain taxable : 50 % du montant des gains nets ou des distributions lorsque les titres ou droits sont détenus depuis au moins deux ans et moins de huit ans à la date de la cession ou de la distribution et 65 % de leur montant lorsque les titres ou droits sont détenus depuis au moins huit ans.

La durée de détention est décomptée à partir de la date de souscription ou d'acquisition des titres ou droits et prend fin à la date du transfert de propriété. L'abattement s'applique sur les gains nets, déterminés après compensation des plus-values et des moins-values brutes.

Cet abattement pour durée de détention n'est applicable que pour l'imposition au barème progressif et non pour l'assujettissement aux prélèvements sociaux.

Les plus-values de cession de valeurs mobilières peuvent également être soumises à la contribution sur les hauts revenus (qui s'applique pour les contribuables célibataires au taux de 3% pour les revenus compris entre €250 000 et €500 000 et au taux de 4% pour les revenus au-delà / pour les contribuables mariés au taux de 3% pour les revenus compris entre €500 000 et €1 000 000 et au taux de 4% au-delà). La contribution sur les hauts revenus a pour base 100% du gain taxable, sans prise en compte de l’abattement pour durée de détention.

TAXATION DES DIVIDENDES Suisse

Les dividendes encaissés ou réinvestis directement dans de nouveaux bons de jouissance sont soumis à l’impôt anticipé de 35%. Cependant, compte tenu de la convention de double imposition conclue entre la Suisse et la France, cet impôt à la source peut être ramené à 15% à condition que vous en fassiez la demande en temps utile. France

Les dividendes doivent être reportés dans la déclaration française des revenus de l’année de leur encaissement

(e.g. les dividendes perçus en 2015 doivent être reportés dans la déclaration française des revenus 2015, à

déposer en 2016).

Vous pouvez bénéficier d’un crédit d’impôt égal à l’impôt fictif conventionnel prévu dans la convention fiscale franco-suisse venant en déduction de votre impôt sur le revenu, mais uniquement à concurrence du montant de l’impôt français afférent à ces revenus.

IMPÔT SUR LA FORTUNE Suisse

Les frontaliers français ne sont pas soumis à l’impôt sur la fortune en Suisse. France

Les frontaliers français peuvent être soumis à l’impôt sur la fortune en France (ISF).

Les contribuables dont le patrimoine net excède €1 300 000 au 1er janvier de l’année d’imposition sont soumis à

l’ISF aux taux progressifs allant de 0,5% à 1,5%, applicables à la valeur nette du patrimoine (compensation entre la valeur brute des actifs et des dettes certaines au 1

er janvier de l’année d’imposition).

Bien que les contribuables dont le patrimoine net n’excède pas €1 300 000 ne soient pas soumis à l’impôt sur la fortune en France, lorsque ce seuil de €1 300 000 est atteint, les taux progressifs de l’ISF s’appliquent à la valeur nette du patrimoine au-delà de €800 000.

Roche Connect

Application form

To be completed by Roche employees who are eligible to participate in the plan ("Roche Connect") and wish to enrol.

Title (e.g. Dr, Ms, Mr): Employee ID:

Surname: First name:

Home address:

Telephone numbers:

Nationality: Date of birth:

I hereby subscribe an amount for the purchase of Roche non-voting equity securities in accordance with the terms and conditions and rules governing "Roche Connect". My annual contribution is:

Annual amount in Swiss francs (CHF)

My annual contribution will be divided by the number of regular payment periods in a year.

(minimum 0.5% and maximum 10% of my gross annual income).

PLAN DETAILS

Details of this plan can be found in the employee guide and in the legally binding Rules governing the Roche non-voting equity securities purchase plan "Roche Connect".

PARTICIPATION AND CONTRIBUTIONS

Contributions will be deducted from my salary. Once a year I will have the opportunity to alter the amount of my contributions or to decide to cease making contributions. From 2003, this will be in April/May for contributions effective from June onwards.

DIVIDENDS ON NON-VOTING EQUITY SECURITIES

Any dividends paid on non-voting equity securities held in my Roche Connect account will be credited to this account net of any taxes. The dividends paid will be used to purchase new non-voting equity securities (in this case, without discount).

CONSIDERATION OF TAXES AND SOCIAL SECURITY CONTRIBUTIONS

When deciding if and what amount of my base salary I wish to invest in non-voting equity securities, I must take into consideration the taxes and social security contributions due on my salary and on my investments in the Roche Connect plan. I understand that Roche will deduct these taxes and social security contributions from my salary where required by law to withhold such amounts.

ROCHE CONNECT ACCOUNT – CONSENT

I understand that Roche will open a Roche Connect account in my name at Equatex. The account will be run and administered by Equatex.

CONSENT TO THE PROCESSING OF PERSONAL DATA

Roche (and the persons or legal entities associated with the contractual performance of the plan) will treat all personal data confidentially and take all reasonable steps to ensure safe and secure handling of this data. For the purposes of this plan, I consent to the processing of my personal data by the plan administrator and by other persons or legal entities named above).

ACQUISITION IN MY OWN NAME AND FOR MY OWN ACCOUNT

I hereby declare that I am acquiring the non-voting equity securities in my Roche Connect account in my own name as legal and beneficial owner and not as a fiduciary or on behalf of a third party.

ACKNOWLEDGING FUTURE FLUCTUATIONS IN VALUE

My contributions will be used to purchase Roche non-voting equity securities, which earn dividends and are traded on the stock exchange. They may increase or decrease in value, depending on their performance on the stock exchange. Their value may also depend on exchange rate fluctuations. Therefore, no guarantees can be made with respect to the value of the non-voting equity securities. By signing this application form, I confirm that I have taken note of and accept the risk of fluctuations in the value of the non-voting equity securities held in my Roche Connect account.

EMPLOYEE RIGHTS

Neither the entry into force of the plan or the granting of the right to acquire non-voting equity securities under this plan, nor the payment of profit shall be held or construed to confer upon participants any right of continued eligibility to participate in the plan or of continued employment. This applies regardless of the period of time during which participants have drawn benefits from the plan.

US SELLING RESTRICTIONS

This application form is not a public solicitation to acquire securities in the USA, but is intended solely for Roche employees who are eligible to participate in the non-voting equity securities purchase plan ("Roche Connect"). Securities not registered under the 1933 US Securities Act or without a valid exemption from its registration requirements may not be offered or sold in the USA. US nationals who have acquired Roche Connect holdings in Switzerland must sell their Roche Connect non-voting equity securities before they return to the USA.

APPLICABLE LAW AND DISPUTES

The plan and related documents shall be governed by and construed in accordance with the laws of Switzerland, ignoring the principles of international private law. The plan is further subject to the limitations of compulsory local employment laws. Disputes relating to the interpretation of the plan are to be resolved by the courts of the City of Basel, Switzerland. Disputes relating to the employment relationship, on the other hand, are to be handled by the local courts in the jurisdiction of the participants' employer, except where special arrangements exist.

I take note of and accept the terms and conditions and regulations of this plan and all related documents. I also accept the powers of the Corporate Executive Committee to supplement this plan through further documents, to interpret it and to perform any other actions that may be required from time to time.

I understand that Roche will review the information provided in this application form and subsequently notify me in writing of my participation in the plan.

Place / Date Participant

Please sign this application form and return it to your local Roche Connect Administrator

Building 657/24.013 and keep a copy for your records.