information on the selected research...

ICN PhD Program Aix – Marseille University

INFORMATION ON THE SELECTED RESEARCH PROJECTS

Information on research project #1 Laboratory: Institut de Neurosciences de la Timone, UMR 7289 Head of the laboratory: Guillaume Masson Team name: (P3M) Plasticité et Physio-Pathologie des Réseaux Moteurs Rythmiques Team leader: Frédéric Brocard Title of the proposed PhD research project: Do neuronal oscillators set the pace in rhythmogenic motor

networks? First name and last name of the proposed PhD supervisor(s): Frédéric Brocard, Jean-Charles Viemari. Names and PhD year of the currently supervised PhD students: Irene Sanchez, 4th year. Names and dates of the previously supervised PhD students: Vanessa Plantier (PhD defense 2015), Mouloud Bouhadfane (PhD defense 2014), Sabrina Tazerart (PhD defense 2010), Aurélie Stil (PhD defense 2011), Bellot Blandine (MD defense 2013). Publications (underline the names) of the previously supervised PhD students: ● SANCHEZ BRUALLA I, BOULENGUEZ P, BROCARD C, LIABEUF S, VIALLAT-LIEUTAUD A, NAVARRO X, UDINA E,

BROCARD F (2017). Activation of 5-HT2A receptors restores KCC2 function and reduces neuropathic pain after spinal cord injury. Neuroscience. 2017 Aug 23. pii: S0306-4522(17)30599-7. doi: 10.1016/j.neuroscience.2017.08.033.

● LIABEUF S, STUHL-GOURMAND L, GACKIÈRE F, MANCUSO R, SANCHEZ BRUALLA I, BROCARD F and VINAY L (2017). Prochlorperazine increases KCC2 function and reduces spasticity after spinal cord injury. Journal of Neurotrauma. 2017 Jul 26. doi: 10.1089/neu.2017.5152.

● PLANTIER V and BROCARD F (2017). Spasticity, a new calpainopathy after a spinal cord injury. Med Sci (Paris). n° 6-7, vol 33 : 629-36.

● BROCARD C, PLANTIER V, BOULENGUEZ P, LIABEUF S, BOUHADFANE M, VIALLAT-LIEUTAUD A, VINAY L, BROCARD F (2016). Calpain-mediated proteolytic cleavage of sodium channels after spinal cord injury increases the persistent sodium current and contributes to spasticity. Nat Medicine doi :10.1038/nm.4061.

● BOUHADFANE M, KASZÁS A, RÓZSA B, HARRIS-WARRICK RM, VINAY L, BROCARD F. (2015). Sensitization of neonatal rat lumbar motoneuron by the inflammatory pain mediator bradykinin. Elife. 2015 Mar 17;4. doi: 10.7554/eLife.06195.

● BOUHADFANE M, TAZERART S, MOQRICH A, VINAY L, BROCARD F. (2013). Sodium-mediated plateau potentials in lumbar motoneurons of neonatal rats. J Neurosci. 33: 15626-41.

● BROCARD F, SHEVTSOVA. N, BOUHADFANE M, TAZERART S, HEINEMANN U, RYBAK I.A, VINAY L. (2013). Activity-dependent changes in extracellular Ca2+ and K+ reveal pacemakers in the spinal locomotor-related network. Neuron. 77: 1047-54.

● BROCARD F, TAZERART S, VINAY L. (2010) Do pacemakers drive the central pattern generator for locomotion in mammals? Neuroscientist. 16: 139-55.

● SADLAOUD K, TAZERART S, BROCARD C, JEAN-XAVIER C, PORTALIER P, BROCARD F, VINAY L, BRAS H. (2010) Differential maturational plasticity of the GABAergic and glycinergic synaptic transmission to rat lumbar motoneurons after spinal cord injury. J Neurosci. 30: 3358-69.

● TAZERART S, VINAY L, BROCARD F. (2008) The persistent sodium current generates pacemaker activities in the central pattern generator for locomotion and regulates the locomotor rhythm. J Neurosci. 28: 8577-89.

● TAZERART S, VIEMARI JC, DARBON P, VINAY L, BROCARD F. (2007). Contribution of persistent sodium current to locomotor pattern generation in neonatal rats. J Neurophysiol. 98:613-28.

BELLOT B, PEYRONNET- ROUX J, GIRE C, SIMEONI U, VINAY L. AND VIEMARI. J-C. Deficits of brainstem and spinal cord functions after neonatal hypoxia-ischemia in mice. Ped. Res, 2014 Jun;75(6):723-30

STIL A., JEAN-XAVIER C., LIABEUF S., BROCARD C., DELPIRE E., VINAY L. AND VIEMARI J-C. Contribution of the potassium chloride co-transpoter KCC2 to the modulation of lumbar spinal networks in mice. Eur. J. Neurosci, 2011, jan (24).

STIL, A., LIABEUF, S., JEAN-XAVIER, C., BROCARD, C., VIEMARI, J-C., VINAY, L., Developmental up-regulation of the cation-chloride cotransporter KCC2 in the rat lumbar spinal cord, Neuroscience, Dec 1;164(2):809-21, 2009.

http://www.ncbi.nlm.nih.gov.gate1.inist.fr/pubmed/20420834

http://www.ncbi.nlm.nih.gov.gate1.inist.fr/pubmed/20420834

Information on research project #2

Laboratory: Developmental Biology Institute of Marseille (IBDM) Head of the laboratory: André Le Bivic Team leader(s): Laurent Fasano First name and last name of the proposed PhD supervisor(s): Xavier Caubit Title of the proposed PhD research project: From novel Tshz3 mouse models to understanding pathophysiology of autism spectrum disorder Names and PhD year of the currently supervised PhD students: Irene Sanchez-Martin, 3rd year Names and dates of the previously supervised PhD students: M. Armel Gallet - Thèse soutenue en 1999 / Mlle Corinne Angelats - Thèse soutenue en 2000 / Mme Ouarda Taghli-Lamalem - Thèse soutenue en 2001 / M. Daniel Papillon - Thèse soutenue en 2004 / M. Hervé Faralli - Thèse soutenue en 2010. / Mlle Elise Martin - Thèse soutenue en 2010 / Mlle Silvia Pimentel - Thèse soutenue en 2011 (Lisbonne ; Portugal). Publications of the previously supervised PhD students (underline the names): 1. Martin E, Caubit X, Airik R, Vola C, Fatmi A, Kispert A, Fasano L. TSHZ3 and SOX9 Regulate the Timing of Smooth Muscle Cell Differentiation in the Ureter by Reducing Myocardin Activity. PLoS One. 2013 May 6;8(5) 2. "Teashirt in cell proliferation "; Silvia Pimentel, Rui Gomes and Laurent Fasano; LAP Lambert Academic Publishing (2012). ISBN 978-3-8484-2850-2. 3. Faralli H, Martin E, Coré N, Liu QC, Filippi P, Dilworth FJ, Caubit X, Fasano L. Teashirt-3, a novel regulator of muscle differentiation, associates with BRG1-associated factor 57 (BAF57) to inhibit myogenin gene expression. J Biol Chem. 2011 Jul 1;286(26):23498-510. 4. Caubit X, Thoby-Brisson M, Voituron N, Filippi P, Bévengut M, Faralli H, Zanella S, Fortin G, Hilaire G, Fasano L. Teashirt3 regulates development of neurons involved in both respiratory rhythm and airflow control. J Neurosci. 2010 Jul 14;30(28):9465-76. 5. Caubit X1, Lye CM1, Martin E1, Coré N, Long DA, Vola C, Jenkins D, Garratt AN, Skaer H, Woolf AS, Fasano L. Teashirt 3 is necessary for ureteral smooth muscle differentiation downstream of SHH and BMP4. Development. 2008 Oct;135(19):3301-10. 1 first co-authors. 6. Taghli-Lamallem O, Gallet A, Leroy F, Malapert P, Vola C, Kerridge S, Fasano L. Direct interaction between Teashirt and Sex combs reduced proteins, via Tsh's acidic domain, is essential for specifying the identity of the prothorax in Drosophila. Dev Biol. 2007 Jul 1;307(1):142-51. 7. Marlétaz F, Martin E, Perez Y, Papillon D, Caubit X, Lowe CJ, Freeman B, Fasano L, Dossat C, Wincker P, Weissenbach J, Le Parco Y. Chaetognath phylogenomics: a protostome with deuterostome-like development. Curr Biol. 2006 Aug 8;16(15):R577-8. 8. Papillon D, Perez Y, Caubit X, Le Parco Y. (2006). Systematics of Chaetognatha under the light of molecular data, using duplicated ribosomal 18S DNA sequences. J. Mol. Phyl. Evol. 38(3):621-34. 9. Papillon D, Perez Y, Fasano L, Le Parco Y, Caubit X. Restricted expression of a median Hox gene in the central nervous system of chaetognaths. Dev Genes Evol. 2005 Mar 24 10. Papillon D, Perez Y, Caubit X, Le Parco Y. (2004). Identification of Chaetognaths as Protostomes Is Supported by the Analysis of Their Mitochondrial Genome. Mol Biol Evol. 21(11):2122-29. 11. Papillon D, Perez Y, Fasano L, Le Parco Y, Caubit X. Hox gene survey in the chaetognath Spadella cephaloptera: evolutionary implications. Dev Genes Evol. 2003 Apr;213(3):142-8. Epub 2003 Mar 11. 12. Nicolas S, Papillon D, Perez Y, Caubit X, Le Parco Y (2003). The spatial restrictions of 5'HoxC genes expression are maintained in adult newt spinal cord. Biol Cell. 95(9):589-94. 13. Angelats C, Gallet A, Therond P, Fasano L, Kerridge S. Cubitus interruptus acts to specify naked cuticle in the trunk of Drosophila embryos. Dev Biol. 2002 Jan 1;241(1):132-44. 14. Erkner A, Roure A, Charroux B, Delaage M, Holway N, Core N, Vola C, Angelats C, Pages F, Fasano L, Kerridge S. Grunge, related to human Atrophinlike proteins, has multiple functions in Drosophila development. Development. 2002 Mar;129(5):1119-29. 15. Gallet, A, Erkner A, Charroux B, Fasano L, Kerridge S (1999). The C-terminal domain of Armadillo binds to hypophosporylated Teashirt to modulate Wingless signalling in Drosophila. EMBO. J. Apr 15;18(8):2208-17. 16. Erkner A, Gallet A, Angelats C, Fasano L, Kerridge S (1999). The Role of Teashirt in Proximal Leg Development in Drosophila: Ectopic teashirt Expression Reveals Different Cell Behaviours in Ventral and Dorsal Domains. Dev Biol Nov 15;215(2):221-232 17. Gallet A, Erkner A, Charroux B, Fasano L, Kerridge S (1998). Trunk-specific modulation of wingless signalling in Drosophila by teashirt binding to armadillo. Curr Biol. 1998 Jul 30-Aug 13;8(16):893-902. 18. E. Alexandre, Y. Graba, L. Fasano, A. Gallet, L. Perrin, P. de Zulueta, J. Pradel, S. Kerridge and B. Jacq. (1996). The Drosophila Teashirt homeotic protein is a DNA-binding protein and modulo, a HOM-C regulated modifier of variegation, is a likely candidate for being a direct targets gene. Mechanisms of Development 59, 191-204.

Information on research project #3 Laboratory: Developmental Biology Institute of Marseille (IBDM) Head of the laboratory: Andre Le Bivic Team name: Molecular Control of Neurogenesis Team leader(s): Harold Cremer First name and last name of the proposed PhD supervisor(s): Harold Cremer, Jean-Claude Platel Title of the proposed PhD research project: Understanding l ife and death in the nervous system: 2- photon in vivo microscopy to study neuronal integration in the adult brain Names and PhD year of the currently supervised PhD students: Alexandra Angelova, 3rd year, defense foreseen 12/2018 Tiveron MC, Beclin C, Murgan S, Wild S, Angelova A, Marc J, Coré N, de Chevigny A, Herrera E, Bosio A, Bertrand V and Cremer H (2017) Zic-proteins are repressors of dopaminergic forebrain fate in mice and C. elegans, J. Neuroscience 29, 3888-16 Neuronal Subtype Generation During Postnatal Olfactory Bulb Neurogenesis, Alexandra Angelova, Marie-Catherine Tiveron, Harold Cremer and Christophe Beclin, Experimental Neurology 2018, in press Structural and functional characterization of postnatal born glutamatergic forbebrain neurons. Alexandra Angelova, Jean Claude-Platel, Harold Cremer, Nathalie Coré, submitted to Development. Names and dates of the previously supervised PhD students: Stephane Bugeon, date of defense 12/2017

Bugeon,S., de Chevigny, A., Boutin, C., Coré, N., Wild, S., Bosio, A. Cremer, H. (co-senior, corresponding author), Beclin, C. (2017) Direct and efficient transfection of mouse neural stem cells and mature neurons by in vivo mRNA electroporation, Development, 144(21):3968-3977. doi: 10.1242/dev.151381

Falk S, Bugeon S, Ninkovic J, Pilz GA, Postiglione MP, Cremer H, Knoblich JA, Götz M. (2017) Time-Specific Effects of Spindle Positioning on Embryonic Progenitor Pool Composition and Adult Neural Stem Cell Seeding, Neuron 93, 777–791

Submitted: Bugeon S. Sahra Lafi ........Harold Cremer and Antoine de Chevigny, Morphofunctional alterations in the neocortex of NeuroD2 knock-out mice are associated with autism/schizophrenia-like behaviors; Nature communications, under review

In preparation: Bugeon, S., Haubold, C., Cremer, H., Platel, JC, Regulation of neuronal migration and positioning in the postnatal forebrain: role of activity. Phillip Follert, PhD student 2011-2015

Follert P, Cremer H, Béclin C, (2014) MicroRNAs in brain development and function: a matter of flexibility and stability. Front Mol Neurosci. 2014 Feb 7;7:5.

Beclin C, Follert P (co-first authors), Stappers E, Barral S, Nathalie C, de Chevigny A, Magnone V, Lebrigand K, Bissels U, Huylebroeck D, Bosio A, Barbry P, Seuntjens E, Cremer H. (2016) miR-200 family controls late steps of postnatal forebrain neurogenesis via Zeb2 inhibition. Scientific Reports; 6:39368. doi: 10.1038/srep39368

de Chevigny A, Core N, Follert P, Wild S, Bosio A, Yoshikawa K, Cremer H and Beclin C., (2012) Dynamic expression of the pro-dopaminergic transcription factors Pax6 and Dlx2 during postnatal olfactory bulb neurogenesis, Frontiers in Neuroscience 6: 6

de Chevigny A, Coré N (co-first authors), Follert P, Gaudin N, Barbry P, Béclin C and Cremer H (2012) miR-7a regulation of Pax6 in neural stem cells controls the spatial origin of forebrain dopaminergic neurons, Nature Neuroscience 15(8):1120-6,doi:10.1038/nn.3142 Camille Boutin, PhD student 2008-2012

Burk K., Desoeuvre A (co-first authors), Boutin C, Martin SA, Kröger S, Bosio A, Tiveron MC and Cremer H. Agrin-signalling is necessary for the integration of newly generated neurons in the adult olfactory bulb, (2012) J. Neuroscience 32 (11): 3759-64

Courtès S, Vernerey J, Pujadas L, Magalon K, Cremer H, Soriano E, Durbec P, Cayre M (2011) Reelin controls progenitor cell migration in the healthy and pathological adult mouse brain, PLoS One. 2011;6(5):e20430.

Fernandez ME, Croce S, Boutin C, Cremer H, Raineteau O. (2011) Targeted electroporation of defined lateral ventricular walls: a novel and rapid method to study fate specification during postnatal forebrain neurogenesis. Neural Dev. 6(1):13

Tiveron MC, Boutin, C, Daou P, Moepps B, Cremer H, (2010) Expression and function of CXCR7 in the mouse forebrain, J. Neuroimmunology, 224(1-2):72-9.

Guirao B, Meunier A., Mortaud S, Aguilar A, Corsi JM., Strehl L, Hirota Y, Desoeuvre A, Boutin C, Han YG, Mirzadeh Z, Cremer H, Montcouquiol M, Sawamoto K and Spassky N. (2010), Mammalian motile cilia orientation requires coupling between hydrodynamic forces and planar cell polarity, Nature Cell Biology 12(4):341-50

Boutin C, Hardt O, de Chevigny A, Core N, Goebbels S, Seidenfaden R, Bosio A, Cremer H (2010) NeuroD1 induces terminal neuronal differentiation in olfactory neurogenesis. Proc Natl Acad Sci U S A 107:1201-1206

Boutin, C, Schmitz, B, Cremer, H. and Diestel, S. (HC co-senior author) (2009), NCAM expression induces neurogenesis in vivo, Europ J Neurosci, 30(7):1209-18

Boutin, C., Diestel, S., Desoeuvre, A., Tiveron, M.C., and Cremer, H. (2008). Efficient in vivo electroporation of the postnatal rodent forebrain. PLoS ONE 3, e188


Laboratory: Institute of NeuroPhysiopathology (INP) Head of the laboratory: Michel Khrestchatisky Team name: Cytosquelette et neurophysiopathotlogie – Equipe 9 Team leader(s): Hervé Kovacic & Vincent Peyrot First name and last name of the proposed PhD supervisor(s): François Devred Title of the proposed PhD research project: Rationalized search of plasmatic biomarkers for

neurodegenerative diseases Names and PhD year of the currently supervised PhD students: Romain La Rocca (1st year) Names and dates of the previously supervised PhD students: Andrei Roman from 2014 to 2018 – 60% Roqyia Nouar from 2009 to 2013 – 40%

Publications of the previously supervised PhD students (underline the names):

Andrei Roman :

Philipp O. Tsvetkov, Emeline Tabouret, Andrei Yu. Roman, Sylvie Romain, Céline Bequet, Olga Ishimbaeva, Stéphane Honoré, Dominique Figarella-Branger, Olivier Chinot, Francois Devred Differential Scanning Calorimetry of plasma in glioblastoma: toward a new prognostic / monitoring tool. Oncotarget 2018

Cyrille Garnier, Francois Devred, Deborah Byrne, Rémy Puppo, Andrei Yu. Roman, Soazig Malesinski, Andrey Golovin, Régine Lebrun, Natalia Ninkina, Philipp O. Tsvetkov, RRM domain of TDP-43 binds zinc ions. Scientific Reports 2017 Jul 28;7(1):6812

Andrei Yu. Roman, Francois Devred, Alexander A. Makarov Aslan A. Kubatiev, Vincent Peyrot, Philipp O. Tsvetkov. Sequential binding of calcium ions to B-repeat domain of SdrD from Staphylococcus aureus. Canadian Journal of Microbiology 2016 Feb;62(2):123-9

Roqiya Nouar :

Roqiya Nouar, Gilles Breuzard, Sonia Bastonero, Svetlana Gorokhova, Pascale Barbier, François Devred, Hervé Kovacic, Vincent Peyrot. Direct evidence for the interaction of stathmin with the length and the plus-end of microtubules in cells. FASEB J. 2016 Jun 9.

Gilles Breuzard, Pierre Hubert, Roqiya Nouar, Tiffany De Bessa, François Devred, Pascale Barbier, James Sturgis, and Vincent Peyrot. “Molecular Mechanisms of Tau Binding to Microtubule and its Role in Microtubule Dynamics in Live Cells.” J Cell Sci, 2013 Jul 1;126(Pt 13):2810-9.

Roqiya Nouar, François Devred, Gilles Breuzard, and Vincent Peyrot. " FRET and FRAP imaging: approaches to characterise tau and stathmin interactions with microtubules in cells.” Biol Cell. 2013, Jan 14. 105(4):149-61.

Information on research project #5 Laboratory: INMED/INSERMU1249 Head of the laboratory: Rosa COSSART Team name: Neuronal Coding of Space and Memory Team leader(s): Jérôme EPSZTEIN First name and last name of the proposed PhD supervisor(s): Jérôme EPSZTEIN Title of the proposed PhD research project: Intrinsic excitability and spatial coding in chronic epilepsy Names and PhD year of the currently supervised PhD students: - François-Xavier Michon (4th year of PhD) - Romain Bourboulou (3d year of PhD) Names and dates of the previously supervised PhD students: - David Ouedraogo (2009-2013) Publications of the previously supervised PhD students (underline the names): - Abnormal UP/DOWN membrane potential dynamics coupled with the neocortical slow oscillation in dentate granule cells during the latent phase of temporal lobe epilepsy. Ouedraogo DW, Lenck-Santini PP, Marti G, Robbe D, Crépel V, Epsztein J. eNeuro. 2016 May 31;3(3).


Laboratory: Institut de Neurosciences de La Timone Head of the laboratory: Guillaume Masson Team name: Bagamore Team leader(s): Christelle Baunez First name and last name of the proposed PhD supervisor(s): Alexandre Eusebio and Christelle Baunez

Title of the proposed PhD research project: Cortico-subthalamic nucleus interactions in the encoding of reward-related information

Names and PhD year of the currently supervised PhD students:

Alix Tiran-Cappelo (4th year; defence expected in September 2018)

Names and dates of the previously supervised PhD students:

- Cyril Atkinson-Clément (2014-2017)

- Elodie Giorla (2014-2017)


Atkinson-Clement C, Pinto S, Eusebio A, Coulon O. Diffusion tensor imaging in Parkinson's disease: Review and meta-analysis. Neuroimage Clin. 2017 Jul 15;16:98-110.

Atkinson-Clement C, Sadat J, Pinto S. Behavioral treatments for speech in Parkinson's disease: meta-analyses and review of the literature. Neurodegener Dis Manag. 2015;5(3):233-48.

Atkinson-Clement C, Maillet A, LeBars D, Lavenne F, Redouté J, Krainik A, Pollak P, Thobois S, Pinto S. Subthalamic nucleus stimulation effects on single and combined task performance in Parkinson's disease patients: a PET study. Brain Imaging Behav. 2017 Aug;11(4):1139-1153.

Pinto S, Cardoso R, Sadat J, Guimarães I, Mercier C, Santos H, Atkinson-Clement C, Carvalho J, Welby P, Oliveira P, D'Imperio M, Frota S, Letanneux A, Vigario M, Cruz M, Martins IP, Viallet F, Ferreira JJ. Dysarthria in individuals with Parkinson's disease: a protocol for a binational, cross-sectional, case-controlled study in French and European Portuguese (FraLusoPark). BMJ Open. 2016 Nov 17;6(11):e012885.

Pelloux Y, Meffre J, Giorla E, Baunez C (2014) The subthalamic nucleus keeps you high on emotion: behavioral consequences of its inactivation. Frontiers Behav Neurosci 8:414 ; doi: 10.3389/fnbeh.2014.00414

Giorla E, Nordmann S, Pelloux Y, Roux P, Rosellini S, Davranche K, Huguet P, Carrieri P*, Baunez C*, Presence and familiarity of a peer as key factors to modulate drug intake: translational evidence from rats to cocaine users. Submitted Current Biol.

Montanari C, Giorla E, Pelloux Y, Baunez C “Subthalamic nucleus mediates the modulation on cocaine self-administration induced by ultrasonic vocalizations playback in rats”, submitted PNAS

Atkinson-Clement C, Cavazzini E, Zénon A, Witjas T, Fluchère F, Azulay J-P, Baunez C, Eusebio A. « Decision making based on rewards and efforts: Effects of subthalamic nucleus high frequency stimulation and levodopa treatment in Parkinson’s disease”, Submitted Mov. Dis.


Laboratory: Institut de Neurosciences de la Timone

Head of the laboratory: Guillaume Masson

Team name: miRCoS

Team leader(s): Eduardo Gascon

First name and last name of the proposed PhD supervisor(s): Eduardo Gascon

Title of the proposed PhD research project: Investigating epigenetic mechanisms controlling mice social behavior

Names and PhD year of the currently supervised PhD students: 0

Names and dates of the previously supervised PhD students: 0


Laboratory: Laboratoire de Psychologie Cognitive Head of the laboratory: Johannes Ziegler [email protected] Team name: Cognition comparée Team leader(s): Joel Fagot First name and last name of the proposed PhD supervisor(s): Florence Gaunet (co-supervisor) Anne-Lise Giraud (co-supervisor). Imera position from Feb to June 2019 (LPC and LPL). The student will be 100% based in L.P.C./Marseille. Collaboration with T. Legou/L.P.L. Research conducted in the Labex ILCB framework (Institute of Language, Communication and the Brain). Title of the proposed PhD research project: Contour, rhythm or content? What does dogs brain grasp from human speech? Names and PhD year of the currently supervised PhD students: Supervision FG: none at the moment. Supervision ALG: Sevada Hovsepyan (2018), Johanna Nicolle (2021), Xiaoyue Wang (2022) Names and dates of the previously supervised PhD students: Supervision FG: 2009-12 Carine Savalli, E Pari-Perrin 2009-13, C Duranton 2014-17. Supervision ALG: 2006-09 Luc Arnal, 2007-10 Benjamin Morillon, 2007-10 Diane Lazard, 2008-11 Houda Saoud, 2011-14 Lorenzo Fontolan, 2011-14 Ana-Filipa Borges, 2011-14 Delphine Jochaut, 2012-16 Maria Pefkou. Publications of the previously supervised PhD students (1 key publication with name underlined, link to full list of publications when it applies): ALG/PhD publications: 1. Arnal, L. H., Wyart, V., & Giraud, A. L. 2011. Transitions in neural oscillations reflect prediction errors generated in audiovisual speech. Nature neuroscience, 14(6): 797-801. IF=14.2 (https://www.ncbi.nlm.nih.gov/pubmed/?term=arnal+lh) 4 pub during doctorate 2006-09 2. Morillon, B., Lehongre, K., Frackowiak, R. S., Ducorps, A., Kleinschmidt, A., Poeppel, D., & Giraud, A. L. 2010. Neurophysiological origin of human brain asymmetry for speech and language. Proceedings of the National Academy of Sciences of the United States of America, 107(43): 18688-18693. IF=9.8 (https://www.ncbi.nlm.nih.gov/pubmed/?term=morillon+b) 10 pub during doctorate 2007-2010 3. Lazard DS, Giraud AL. 2017. Brain reorganization associated with fast processing of written-words in acquired deafness shapes cochlear implant outcome. Nature Communications, 8:14872. IF= 10.01 (https://www.ncbi.nlm.nih.gov/pubmed/?term=lazard+ds) 6 pub during doctorate 2007-10 4. Saoud, H., Josse, G., Bertasi, E., Truy, E., Chait, M., & Giraud, A. L. 2012. Brain-Speech Alignment Enhances Auditory Cortical Responses and Speech Perception. The Journal of neuroscience, 32(1): 275-281. IF=7.2 5. Fontolan L, Morillon B, Liegeois-Chauvel C, Giraud AL. 2014. The contribution of frequency-specific activity to hierarchical information processing in human auditory cortices, Nature communications, 5:4694. IF= 10.01 (https://www.ncbi.nlm.nih.gov/pubmed/?term=fontolan+l) 5 pub during doctorate 2011-14 6. Borges F, Giraud AL, Mansvelder HD, Linkenkaer-Hansen K. 2017. Scale-free amplitude modulation of neuronal oscillations signal comprehension of accelerated speech. The Journal of Neuroscience. doi: 10.1523/JNEUROSCI.1515-17.2017. IF=7.2 7. Jochaut D, Lehongre K, Saitovitch A, Devauchelle AD, Olasagasti I, Zilbovocius M, Giraud AL. 2015. Atypical coordination of cortical oscillations in response to speech in autism. Frontiers in Human Neurosciences, 9:171. IF=3 8. Pefkou M, Arnal L, Fontolan L, Giraud AL. 2017. Theta- and beta-band neural activity reflect independent syllable tracking and intelligibility of time-compressed speech. The Journal of Neuroscience 37(33):7930-7938. IF=7.2 FG/PhD publications: 1. GAUNET, F., PARI-PERRIN, E., BERNARDIN, G. (2014). Description of dogs and owners in outdoor built-up areas and their more-than-human issues. Environmental Management, 54(3) 383-401. IF = 2 (https://www.ncbi.nlm.nih.gov/pubmed/?term=pari-perrin+e) 1 pub during doctorate 2009-13 (2 forthcoming) 2. SAVALLI, C., ADES, C & GAUNET, F. (2014). Are dogs able to communicate with their owners about a desirable food in a referential and intentional way? Plos One 9(9): E108003. IF: 4.17 (https://www.ncbi.nlm.nih.gov/pubmed/?term=savalli+c) 2 pub during doctorate 2009-12 3. DURANTON, C., BEDOSSA, T. & GAUNET, F. (2017). Interspecific behavioural synchronization: dogs exhibit locomotor synchrony with humans. Scientific Reports. 7: 12384. IF = 4.3 (https://www.ncbi.nlm.nih.gov/pubmed/?term=duranton+c) 10 pub during doctorate 2014-17

mailto:[email protected]

https://www.ncbi.nlm.nih.gov/pubmed/?term=arnal+lh

https://www.ncbi.nlm.nih.gov/pubmed/?term=morillon+b

https://www.ncbi.nlm.nih.gov/pubmed/?term=lazard+ds

https://www.ncbi.nlm.nih.gov/pubmed/?term=fontolan+l

https://www.ncbi.nlm.nih.gov/pubmed/?term=pari-perrin+e

https://www.ncbi.nlm.nih.gov/pubmed/?term=savalli+c

https://www.ncbi.nlm.nih.gov/pubmed/?term=duranton+c


Laboratory: Inserm UMR 1072 “UNIS” Head of the laboratory: Dominique DEBANNE Team name: Robustness of Excitability Team leader(s): Jean-Marc GOAILLARD First name and last name of the proposed PhD supervisor(s): Jean-Marc GOAILLARD Title of the proposed PhD research project: Single-neuron transcriptome-to-phenotype mapping using combined patch-clamp electrophysiology and microfluidic quantitative PCR Names and PhD year of the currently supervised PhD students: Estelle Moubarak, 4th year Alexis Haddjeri-Hopkins, 3rd year Names and dates of the previously supervised PhD students: Martial Dufour (graduated 15/12/2014) Publications of the previously supervised PhD students (underline the names): 1) Dufour MA, Woodhouse A, Amendola J and Goaillard JM (2014). Non-linear developmental trajectory of electrical phenotype in rat substantia nigra pars compacta dopaminergic neurons. eLife, 20th Oct 2014. 2) Dufour MA, Woodhouse A and Goaillard JM (2014). Somatodendritic ion channel expression in substantia nigra pars compacta dopaminergic neurons across postnatal development. Journal of Neuroscience Research, 92(8): 981-99. 3) Mlayah-Bellalouna S, Dufour M, Mabrouk K, Mejdoub H, Carlier E, Othmane H, Tarbe M, Goaillard JM, Gigmes D, Seagar M, El Ayeb M, Debanne D and Srairi-Abid N (2014). AaTX1, from Androctonus australis scorpion venom: purification, synthesis and characterization in dopaminergic neurons. Toxicon, 92C:14-23. 4) Goaillard JM and Dufour MA (2014). Neuropathic pain: the pros and cons of degeneracy. eLife, 3:e02615.


Laboratory: Institut de Neurobiologie de la Méditerranée (INMED)

Head of the laboratory: Rosa Cossart

Team name: Neurodevelopment and Prader-Willi Syndrome: From gene to therapy

Team leader(s): Françoise Muscatelli

First name and last name of the proposed PhD supervisor(s): co-supervision between Clément Menuet and Françoise Muscatelli

Title of the proposed PhD research project: Anatomo-functionnal dissection of the neuronal networks driving respiratory rhythm generation and respiratory-cardiovascular entrainment

Names and PhD year of the currently supervised PhD students: Alessandra Bertoni, 4th year PhD student (supervised by Françoise Muscatelli)



Laboratory: INS UMR1106 Inserm Head of the laboratory: Viktor JIRSA Team name: Theoretical Neuroscience Group Team leader(s): Viktor Jirsa First name and last name of the proposed PhD supervisor(s): Viktor Jirsa Title of the proposed PhD research project: Functional architectures arising from large-scale brain network dynamics Names and PhD year of the currently supervised PhD students: • Marisa Saggio since 2014, to defend 2018 • Francesca Melozzi since 2014, to defend 2018 • Julie Courtiol since 2014, to defend 2018 • Anirudh Vattikonda since 2017 Names and dates of the previously supervised PhD students (last 5 years only): • Hester Knol (2017), now postdoc in Ulm, Germany • Timothée Proix (2015), now postdoc at Brown University • Sebastien Naze (2015), now senior researcher with IBM • Kenza El Houssaini (2015), now postdoc at INS, Marseille • Enrique Hansen (2015), now postdoc at Ernst-Strüngmann Institut, Frankfurt • Paula Sanz Leon (2014), now postdoc at University of Sydney Publications of the previously supervised PhD students (underline the names, last 5 years only): Saggio ML, Spiegler A, Bernard C, Jirsa VK (2017) Fast-slow bursters in the unfolding of a high codimension singularity and the ultra-slow transitions of classes. Journ Math Neurosci 7, 7. Besson P, Bandt SK, Proix T, Lagarde S, Jirsa VK, Ranjeva JP, Bartolomei F, Guye M (2017). Anatomic consistencies across epilepsies: a stereotactic-EEG informed high-resolution structural connectivity study. Brain 140 (10), 2639 -2652 Proix T, Bartolomei F, Guye M, Jirsa VK (2017) Individual brain structure and modeling predict seizure propagation. Brain 140 (3): 641-654 Knol H, Huys R, Sarrazin JC, Spiegler A, Jirsa VK (2017) Ebbinghaus figures that deceive the eye do not necessarily deceive the hand. Scientific Reports 7, 3111 Melozzi F, Woodman M, Jirsa VK, Bernard C (2017) The Virtual Mouse Brain: A computational neuroinformatics platform to study whole mouse brain dynamics. ENeuro 4 (3), UNSP e0111-17.2017 Courtiol J, Perdikis D, Petkoski S, Müller V, Huys R, Sleimen-Malkoun R, Jirsa VK (2016) The multiscale entropy : Guidelines for use and interprétation in brain signal analysis. Journ Neurosci Methods 273, 175-190. Proix T, Spiegler A, Schirner M, Rothmeier S, Ritter P, Jirsa VK (2016) How do parcellation size and short-range connectivity affect dynamics in large-scale brain network models ? Neuroimage doi :10.1016/j.neuroimage.2016.06.016 Petkoski S, Spiegler A, Proix T, Aram P, Temprado JJ, Jirsa VK (2016) Heterogeneity of time delays determines synchronization of coupled oscillators. Phys Rev E 94, 1, doi : 10.1103/PhysRevE.94.012209 Wirsich J, Perry A, Ridley B, Proix T, Golos M, Bénar C, Ranjeva JP, Bartolomei F, Breakspear M, Jirsa V, Guye M (2016) Whole-brain analytic measures of network communication reveal increased structure-function correlation in right temporal lobe epilepsy. Neuroimage Clin. 2016 May 19;11:707-18. Jirsa VK, Proix T, Perdikis D, Woodman MM, Wang H, Gonzalez-Martinez J, Bernard C, Bénar C, Chauvel P, Bartolomei F (2016) The Virtual Epileptic Patient: Individualized whole-brain models of epilepsy spread. Neuroimage doi :10.1016/j.neuroimage.2016.04.049 Knol H, Huys R, Sarrazin JC, Jirsa VK (2015) Quantifying the Ebbinghaus figure effect : rtarget size, context size, and traget-context distance determine the présence and direction of the illusion. Front Psychol 6 : 1679 Huys R, Knol H, Sleimen-Malkoun R, Temprado JJ, Jirsa VK (2015) Does changing Fitts’ index of difficulty evoke ransitions in movement dynamics ? EPJ Nonlinear Biomedical Physics 3:8 Naze S, Bernard C, Jirsa V (2015) Computational Modeling of Seizure Dynamics Using Coupled Neuronal Networks: Factors Shaping Epileptiform Activity. PLoS Comput Biol 11(5): e1004209. doi:10.1371/journal.pcbi.1004209 Sanz-Leon P, Knock SA, Spiegler A, Jirsa VK (2015) Mathematical framework for large-scale brain network modelling in The Virtual Brain. Neuroimage 1;111:385-430. doi: 10.1016 El Houssaini K, Ivanov AI, Bernard C, Jirsa VK (2015) Seizures, refractory status epilepticus, and depolorization block as endogenous brain activities. Phys Rev E 91, 010701 Hansen ECA, Battaglia D, Spiegler A, Deco G, Jirsa VK (2015) Functional connectivity dynamics: Modeling the switching behavior of the resting state. Neuroimage 105, 525-531 Proix T, Bartolomei F, Chauvel P, Bernard C, Jirsa VK (2014) Permittivity coupling across brain regions determines seizure recruitment in partial epilepsy. The Journal of Neuroscience 34(45):15009 –15021 Woodman MM, Pezard L, Domide L, Knock S, Sanz Leon P, Mersmann J, McIntosh AR, Jirsa VK (2014) Integrating Neuroinformatics Tools in The Virtual Brain. Front. Neuroinform. 8:36. doi: 10.3389/fninf.2014.00036

Information on research project #12 Laboratory: INT & INS Head of the laboratory: Guillaume MASSON & Viktor JIRSA Team name: CoMCo & TNG Team leader(s): T. Brochier & V. Jirsa First name and last name of the proposed PhD supervisor(s): Bjørg Kilavik, HDR (INT, CoMCo) & Demian Battaglia (INS, TNG) Title of the proposed PhD research project: Decoding movement goals and muscle activation patterns from superficial and deep motor cortical layers in non-human primates – determining the suitability for brain machine interfaces Names and PhD year of the currently supervised PhD students: Battaglia: Mohammed Arbabyazd, 2017-…, Computational Neuroscience, AMU (cosupervised by Dr. Viktor Jirsa, INS) Battaglia: Diego Lombardo, 2017-…, Neuroimaging analyses, AMU (co-supervised by Dr. Mira Didic, INS) Battaglia: Shruti Naik, 2018-…, Computational Neuroscience, UPMC (co-supervised by Ghislaine Dehaene, Neurospin) Names and dates of the previously supervised PhD students: Kilavik: Joachim Confais, 2008-2013, Neuroscience, AMU Battaglia: Olav Stetter, 2009-2012, Computational Neuroscience, Georg August University, Göttingen (Germany) (co-supervised by Prof. Dr. Theo Geisel) Battaglia: Markus Helmer, 2012-2015, Computational Neuroscience, Georg August University, Göttingen (Germany) (co-supervised by Prof. Dr. Theo Geisel) Battaglia: Agostina Palmigiano, 2013-2016, Computational Neuroscience, Georg August University, Göttingen (Germany) (co-supervised by Prof. Dr. Theo Geisel) Publications of the previously supervised PhD students (underline the names): Kilavik BE, Roux S, Ponce-Alvarez A, Confais J, Grün S, Riehle A (2009) Long-term modifications in motor cortical dynamics induced by intensive practice. J Neurosci29: 12653-12663 Kilavik BE, Confais J, Ponce-Alvarez A, Diesmann M, Riehle A (2010) Evoked potentials in motor cortical local field potentials reflect task timing and behavioral performance. J Neurophysiol 104: 2338-2351 Kilavik BE, Ponce-Alvarez A, Trachel R, Confais J, Takerkart S, Riehle A (2012) Context-related frequency modulations of macaque motor cortical LFP beta oscillations. Cereb Cortex 22: 2148-2159 Confais J, Kilavik BE, Ponce-Alvarez A, Riehle A (2012) On the anticipatory pre-cue activity in motor cortex. J Neurosci 32: 15359-68 Kilavik BE, Confais J, Riehle A (2014) Signs of timing in motor cortex during movement preparation and cue anticipation. Adv Exp Med Biol 829: 121-142 Stetter O, Battaglia D, Soriano J, Geisel T (2012). Model-free reconstruction of excitatory neuronal connectivity from calcium imaging signals. PLoS Comp Biol 8: e1002653. Witt A, Palmigiano A, Neef A, Hady El A, Wolf F, Battaglia D (2013). Controlling the oscillation phase through precisely timed closed-loop optogenetic stimulation: a computational study. Front Neural Circuits 7: 49. Orlandi JG, Stetter O, Soriano J, Geisel T, Battaglia D (2014). Transfer entropy reconstruction and labeling of neuronal connections from simulated calcium imaging. PLoS ONE 9: e98842. Helmer M, Kozyrev V, Stephan V, Treue S, Geisel T, Battaglia D (2016). Model-Free Estimation of Tuning Curves and Their Attentional Modulation, Based on Sparse and Noisy Data. PLoS ONE 11: e0146500. Helmer M, Schottdorf M, Neef A, Battaglia D (2017). Gender bias in scholarly peer review (2017). eLife 6: 103. Palmigiano A, Geisel T, Wolf F, Battaglia D (2017) Flexible information routing by transient synchrony. Nat Neurosci 20(7):1014–1022. Helmer M, Chen XJ, Wei W, Wolf F, Battaglia D (2018). Connectome of a model local cortical circuit flexibly shapes layer-dependent multi-frequency oscillations, in press on PLoS Computational Biology. Available as preprint on bioRxiv. doi:10.1101/026674


Laboratory: NeuroPathophysiology Institute (INP AMU-CNRS UMR 7051)

Head of the laboratory: Michel Khrestchatisky

Team name: NeuroCyto: The Neuronal Cytoskeleton in Physiology and Disease (CNRS ATIP team)

Team leader(s): Christophe Leterrier

First name and last name of the proposed PhD supervisor(s):

Christophe Leterrier / Marie-Jeanne Papandréou

Title of the proposed PhD research project:

Role of actin nanostructures in presynaptic assembly and function

Names and PhD year of the currently supervised PhD students: -

Names and dates of the previously supervised PhD students: -

Publications of the previously supervised PhD students (underline the names): -


Laboratory: Neurosciences Sensorielles et Cognitives / Sensory and Cognitive Neuroscience (UMR 7260)

Head of the laboratory: Dr Béatrice Alescio-Lautier

Team name: MULTISENSE & BODY

Team leader: Dr Anne Kavounoudias

First name and last name of the proposed PhD supervisor:

Dr Christophe Lopez (CNRS CR1, HDR)

Title of the proposed PhD research project:

Electrophysiological and clinical investigations of the vestibular and multisensory contributions to bodily self-consciousness

Names and PhD year of the currently supervised PhD students:

Estelle Nakul, 2nd year PhD candidate


Diane Deroualle (2013-2017)


1. DEROUALLE D., TOUPET M., VAN NECHEL C., DUQUESNE U., HAUTEFORT C. and LOPEZ C. (2017) Anchoring the self to the body in chronic bilateral vestibular failure. Plos One, 12(1):e0170488.

2. DEROUALLE D., BOREL L., DEVÈZE A. and LOPEZ C. (2015) Changing perspective: the role of vestibular signals. Neuropsychologia, 79: 175–185.

3. LOPEZ C., FALCONER C.J., DEROUALLE D. and MAST F.W. (2015) In the presence of others: self-location, balance control and vestibular processing. Neurophysiologie Clinique/Clinical Neurophysiology, 45: 241–254.

4. DEROUALLE D. and LOPEZ C. (2014) Toward a vestibular contribution to social cognition. Frontiers in Integrative Neuroscience, 8:16.

Information on research project #15 Laboratory: Institut de Neurosciences de la Timone (INT) Head of the laboratory: Guillaume Masson Team name: InViBe Team leader(s): Guillaume Masson First name and last name of the proposed PhD supervisor(s): Anna Montagnini (HDR submitted) Title of the proposed PhD research project: Bayesian inference in visuomotor decisions: eye movement analysis and modeling Names and PhD year of the currently supervised PhD students: - Jean-Bernard Damasse, thesis: Gaze orientation and reinforcement (4th and last year: PhD defense expected in June 2018)- co-supervised with Laurent Perrinet - Kiana Mansour Pour, thesis: Predicting sensory events and inference for visuomotor control (3rd

year: 4th year probably needed)- co-supervised with Guillaume Masson Names and dates of the previously supervised PhD students: _ Mathieu Servant (2011-2015), thesis: Cognitive control and decision-making: an experimental and computational integrated account co-supervised by Anna Montagnini and Boris Burle (LNC Marseille) _ Claudio Simoncini (2008-2013), thesis: Intégration spatio-temporelle de l’information visuelle pour les mouvements oculaires et la perception co-supervised by Anna Montagnini and Guillaume Masson _ Amarender Bogadhi, (2008-2012) thesis: An experimental and theoretical study of Visual motion integration for Smooth pursuit - A hierarchical recurrent Bayesian framework perception – cosupervised by Anna Montagnini and Guillaume Masson Publications of the previously supervised PhD students (underline the names): J-B. Damasse, L. Perrinet, L. Madelain and A. Montagnini, Learning effects in anticipatory smooth eye movements, submitted. M. Servant, C.White, A. Montagnini and B. Burle (2016). Linking theoretical decision-making mechanisms in the Simon task with electrophysiological data: a model-based neuroscience study in humans. Journal of Cognitive Neuroscience 28(10):1501-21. M.Servant, C. White, A.Montagnini and B.Burle. (2015). Using covert response activation to test latent assumptions of formal decision-making models in humans. The Journal of Neuroscience, 35(28): 10371-10385. M.Servant, A.Montagnini and B.Burle. (2014). Conflict tasks and the diffusion framework: Insight in model constraints based on psychological laws, Cognitive Psychology, 72: 162-195. AR Bogadhi, A Montagnini & GS Masson (2013). Dynamic interaction between retinal and extraretinal signals in motion integration for smooth pursuit, Journal of Vision, 13(13):5, 1–26. C.Simoncini, L.U. Perrinet, A. Montagnini, P. Mamassian and G.S. Masson (2012) More is not always better: dissociation between perception and action explained by adaptive gain control. Nature Neuroscience 15(11):1596-603. A.R. Bogadhi, A. Montagnini, P.Mamassian, L.U. Perrinet and G.S. Masson (2011). Pursuing motion illusions: a realistic oculomotor framework for Bayesian inference. Vision Research 51: 867–880


Laboratory: Institut de Neurosciences des Systèmes - INSERM U1106 - AMU Head of the laboratory: Viktor Jirsa Team name: PhysioNet Team leader(s): Christophe Bernard First name and last name of the proposed PhD supervisor(s): Pascale Quilichini & Monique Esclapez Title of the proposed PhD research project: Role of Nucleus Reuniens neurons in long term memory consolidation Names and PhD year of the currently supervised PhD students: Maëva Ferraris, 3eme année (Pascale Quilichini & Christophe Bernard) Heba Elsaidy, 3eme année (Monique Esclapez) Names and dates of the previously supervised PhD students: Thomas Doublet, 2010-2013 Rabia Soussi, 2007-2012 Céline Dinocourt, 1999-2002 Publications of the previously supervised PhD students (underline the names): Ferraris M, Ghestem A, Vicente AF, Nallet-Khosrofian L, Bernard C, Quilichini PP (2018) The nucleus reuniens controls long-range hippocampo-prefrontal gamma synchronization during slow oscillations. Journal of Neuroscience, sous presse. Williamson A, Ferro M, Leleux P, Ismailova E, Kaszas A, Doublet T, Quilichini P, Rivnay J, Rózsa B, Katona G, Bernard C, Malliaras GG (2015) Localized Neuron Stimulation with Organic Electrochemical Transistors on Delaminating Depth Probes. Advanced Materials 27:4405-4410. Soussi R, Boulland JL, Bassot E, Bras H, Coulon P, Chaudhry FA, Storm-Mathisen J, Ferhat L, Esclapez M (2015) Reorganization of supramammillary-hippocampal pathways in the rat pilocarpine model of temporal lobe epilepsy: evidence for axon terminal sprouting. Brain Struct Funct. 220(4):2449-68. Khodagholy D, Doublet T, Quilichini P, Gurfinkel M, Leleux P, Ghestem A, Ismailova E, Hervé T, Sanaur S, Bernard C, Malliaras GG (2013) In vivo recordings of brain activity using organic transistors. Nature communications 4:1575-1575. Ismailova E, Doublet T, Khodagholy D, Quilichini P, Ghestem A, Yang SY, Bernard C, Malliaras GG (2012) Plastic neuronal probes for implantation in cortical and subcortical areas of the rat brain. Intl Journal of Nanotech 9:517-517. Chauviere L, Doublet T, Ghestem A, Siyoucef SS, Wendling F, Huys R, Jirsa V, Bartolomei F, Bernard C (2012) Changes in interictal spike features precede the onset of temporal lobe epilepsy. Annals of neurology 71:805-814. Khodagholy D, Doublet T, Gurfinkel M, Quilichini P, Ismailova E, Leleux P, Herve T, Sanaur S, Bernard C, Malliaras GG (2011) Highly conformable conducting polymer electrodes for in vivo recordings. Advanced materials 23:H268-272. Soussi R, Zhang N, Tahtakran S, Houser CR, Esclapez M (2010) Heterogeneity of the supramammillary-hippocampal pathways: evidence for a unique GABAergic neurotransmitter phenotype and regional differences. Eur J Neurosci. 32(5):771-85. Dinocourt C, Petanjek Z, Freund TF, Ben-Ari Y, Esclapez M (2003) Loss of interneurons innervating pyramidal cell dendrites and axon initial segments in the CA1 region of the hippocampus following pilocarpine-induced seizures. J Comp Neurol. 459(4):407-25. Cossart R, Tyzio R, Dinocourt C, Esclapez M, Hirsch JC, Ben-Ari Y, Bernard C (2001) Presynaptic kainate receptors that enhance the release of GABA on CA1 hippocampal interneurons. Neuron. 29(2):497-508. Cossart R, Dinocourt C, Hirsch JC, Merchan-Perez A, De Felipe J, Ben-Ari Y, Esclapez M, Bernard C (2001) Dendritic but not somatic GABAergic inhibition is decreased in experimental epilepsy. Nat Neurosci. 4(1):52-62.

Information on research project #17 Laboratory: CRMBM (Center for Magnetic Resonance in Biology and Medicine) http://crmbm.univ-amu.fr Head of the laboratory: Dr Monique Bernard Team name: Central Nervous System Team leader(s): Pr Jean-Philippe Ranjeva First name and last name of the proposed PhD supervisor(s): Jean-Philippe Ranjeva (HDR) and co-supervisor: Wafaa Zaaraoui (HDR expected for Sept 2018) Title of the proposed PhD research project: In vivo assessment of neuro-axonal degeneration in multiple sclerosis patients using diffusion MR spectroscopy at 7T Names and PhD year of the currently supervised PhD students: No PhD student currently supervised Names and dates of the previously supervised PhD students: Maxime Donadieu, supervised by JPR, defended his PhD thesis in December 2017 Adil Maarouf, supervised by JPR and WZ, defended his PhD thesis In January 2017 Publications of the previously supervised PhD students (underline the names): Increased total sodium concentration in gray matter better explains cognition than atrophy in MS. Maarouf A, Audoin B, Pariollaud F, Gherib S, Rico A, Soulier E, Confort-Gouny S, Guye M, Schad L, Pelletier J, Ranjeva JP, Zaaraoui W. Neurology. 2017 Jan 17;88(3):289-295. Ultra-small superparamagnetic iron oxide enhancement is associated with higher loss of brain tissue structure in clinically isolated syndrome. Maarouf A, Ferré JC, Zaaraoui W, Le Troter A, Bannier E, Berry I, Guye M, Pierot L, Barillot C, Pelletier J, Tourbah A, Edan G, Audoin B, Ranjeva JP. Mult Scler. 2016 Jul;22(8):1032-9. Topography of brain sodium accumulation in progressive multiple sclerosis. Maarouf A, Audoin B, Konstandin S, Rico A, Soulier E, Reuter F, Le Troter A, Confort-Gouny S, Cozzone PJ, Guye M, Schad LR, Pelletier J, Ranjeva JP, Zaaraoui W. MAGMA. 2014 Feb;27(1):53-62. Diffusion MRI abnormalities detection with orientation distribution functions: a multiple sclerosis longitudinal study. Commowick O, Maarouf A, Ferré JC, Ranjeva JP, Edan G, Barillot C. Med Image Anal. 2015 May;22(1):114-23. Metabolic counterparts of sodium accumulation in multiple sclerosis: A whole brain 23Na-MRI and fast 1H-MRSI study. Donadieu M, Le Fur Y, Maarouf A, Gherib S, Ridley B, Pini L, Rapacchi S, Confort-Gouny S, Guye M, Schad LR, Maudsley AA, Pelletier J, Audoin B, Zaaraoui W, Ranjeva JP. Mult Scler. 2017 Oct 1:1352458517736146. Evidencing different neurochemical profiles between thalamic nuclei using high resolution 2D-PRESS semi-LASER (1)H-MRSI at 7 T. Donadieu M, Le Fur Y, Confort-Gouny S, Le Troter A, Guye M, Ranjeva JP. MAGMA. 2016 Jun;29(3):491-501. Metabolic voxel-based analysis of the complete human brain using fast 3D-MRSI: Proof of concept in multiple sclerosis. Donadieu M, Le Fur Y, Lecocq A, Maudsley AA, Gherib S, Soulier E, Confort-Gouny S, Pariollaud F, Ranjeva MP, Pelletier J, Guye M, Zaaraoui W, Audoin B, Ranjeva JP. J Magn Reson Imaging. 2016 Aug;44(2):411-9.


Laboratory: INS UMR1106 Inserm Head of the laboratory: Viktor JIRSA Team name: Dynamic Brain Mapping Team leader(s): Christian BENAR First name and last name of the proposed PhD supervisor(s): Jean Régis, Viktor Jirsa Title of the proposed PhD research project: Epileptogenicity and Connectivity of Hypothalamic Hamartomas Names and PhD year of the currently supervised PhD students: Jirsa: • Marisa Saggio since 2014, to defend 2018 • Francesca Melozzi since 2014, to defend 2018 • Julie Courtiol since 2014, to defend 2018 • Anirudh Vattikonda since 2017 Names and dates of the previously supervised PhD students: Régis: Cedric Clouchoux (defended 2008) now Ingénieur R&D, NEOXIA, Technologies et services de l’information Paris, Atomic Energy and Alternative Energies Commissio, Institute of biomedical imaging (I²BM) Thierry Gevaert (defended 2012) now medical physicist, Vrije Universiteit Brussel, Belgium Beatrice Marcelin (defended 2010) now Senior Market Research Manager - Pharma, Paris, France Jirsa (last 5 years only): • Hester Knol (2017), now postdoc in Ulm, Germany • Timothée Proix (2015), now postdoc at Brown University • Sebastien Naze (2015), now senior researcher with IBM • Kenza El Houssaini (2015), now postdoc at INS, Marseille • Enrique Hansen (2015), now postdoc at Ernst-Strüngmann Institut, Frankfurt • Paula Sanz Leon (2014), now postdoc at University of Sydney Publications of the previously supervised PhD students (underline the names): Régis: C Clouchoux, O Coulon, JL Anton, JF Mangin, J Régis A new cortical surface parcellation model and its automatic implementation. International Conference on Medical Image Computing and Computer-Assisted Intervention , 2006 C Clouchoux, O Coulon, D Rivière, A Cachia, JF Mangin, J Régis. Anatomically constrained surface parameterization for cortical localization, International Conference on Medical Image Computing and Computer-Assisted Intervention, 2005 Clouchoux C, Rivière D, Mangin J-F, Operto G, Régis J, Coulon O. Model-driven parameterization of the cortical surface for localization and inter-subject matching. Neuroimage. 2010 Apr 1;50(2):552–66. Gevaert T, Verellen D, Tournel K, Linthout N, Bral S, Engels B, et al. Setup accuracy of the Novalis ExacTrac 6DOF system for frameless radiosurgery. Int J Radiat Oncol Biol Phys. 2012 Apr 1;82(5):1627–35. Gevaert T, Verellen D, Engels B, Depuydt T, Heuninckx K, Tournel K, et al. Clinical evaluation of a robotic 6-degree of freedom treatment couch for frameless radiosurgery. Int J Radiat Oncol Biol Phys. 2012 May 1;83(1):467–74. Gevaert T, Boussaer M, Engels B, Litré CF, Prieur A, Wdowczyk D, et al. Evaluation of the clinical usefulness for using verification images during frameless radiosurgery. Radiother Oncol. 2013 Jul;108(1):114–7. Marcelin B, Kjäll P, Johansson J, Lundin A, Nordström H, Eriksson M, et al. Using Monte-Carlo-simulated radiation transport to calculate dose distribution in rats before irradiation with Leksell Gamma Knife 4C: technical note. Stereotact Funct Neurosurg. 2010;88(4):208–15. Jirsa (last 5 years only) : Saggio ML, Spiegler A, Bernard C, Jirsa VK (2017) Fast-slow bursters in the unfolding of a high codimension singularity and the ultra-slow transitions of classes. Journ Math Neurosci 7, 7. Besson P, Bandt SK, Proix T, Lagarde S, Jirsa VK, Ranjeva JP, Bartolomei F, Guye M (2017). Anatomic consistencies across epilepsies: a stereotactic-EEG informed high-resolution structural connectivity study. Brain 140 (10), 2639 -2652 Proix T, Bartolomei F, Guye M, Jirsa VK (2017) Individual brain structure and modeling predict seizure propagation. Brain 140 (3): 641-654 Knol H, Huys R, Sarrazin JC, Spiegler A, Jirsa VK (2017) Ebbinghaus figures that deceive the eye do not necessarily deceive the hand. Scientific Reports 7, 3111 Melozzi F, Woodman M, Jirsa VK, Bernard C (2017) The Virtual Mouse Brain: A computational neuroinformatics platform to study whole mouse brain dynamics. ENeuro 4 (3), UNSP e0111-17.2017 Courtiol J, Perdikis D, Petkoski S, Müller V, Huys R, Sleimen-Malkoun R, Jirsa VK (2016) The multiscale entropy : Guidelines for use and interprétation in brain signal analysis. Journ Neurosci Methods 273, 175-190. Proix T, Spiegler A, Schirner M, Rothmeier S, Ritter P, Jirsa VK (2016) How do parcellation size and short-range connectivity affect dynamics in large-scale brain network models ? Neuroimage doi :10.1016/j.neuroimage.2016.06.016 Petkoski S, Spiegler A, Proix T, Aram P, Temprado JJ, Jirsa VK (2016) Heterogeneity of time delays determines synchronization of coupled oscillators. Phys Rev E 94, 1, doi : 10.1103/PhysRevE.94.012209 Wirsich J, Perry A, Ridley B, Proix T, Golos M, Bénar C, Ranjeva JP, Bartolomei F, Breakspear M, Jirsa V, Guye M.(2016) Whole-brain analytic measures of network communication reveal increased structure-function correlation in right temporal lobe epilepsy. Neuroimage Clin. 2016 May 19;11:707-18.

Jirsa VK, Proix T, Perdikis D, Woodman MM, Wang H, Gonzalez-Martinez J, Bernard C, Bénar C, Chauvel P, Bartolomei F (2016) The Virtual Epileptic Patient: Individualized whole-brain models of epilepsy spread. Neuroimage doi :10.1016/j.neuroimage.2016.04.049 Knol H, Huys R, Sarrazin JC, Jirsa VK (2015) Quantifying the Ebbinghaus figure effect : rtarget size, context size, and traget-context distance determine the présence and direction of the illusion. Front Psychol 6 : 1679 Huys R, Knol H, Sleimen-Malkoun R, Temprado JJ, Jirsa VK (2015) Does changing Fitts’ index of difficulty evoke ransitions in movement dynamics ? EPJ Nonlinear Biomedical Physics 3:8 Naze S, Bernard C, Jirsa V (2015) Computational Modeling of Seizure Dynamics Using Coupled Neuronal Networks: Factors Shaping Epileptiform Activity. PLoS Comput Biol 11(5): e1004209. doi:10.1371/journal.pcbi.1004209 Sanz-Leon P, Knock SA, Spiegler A, Jirsa VK (2015) Mathematical framework for large-scale brain network modelling in The Virtual Brain. Neuroimage 1;111:385-430. doi: 10.1016 El Houssaini K, Ivanov AI, Bernard C, Jirsa VK (2015) Seizures, refractory status epilepticus, and depolorization block as endogenous brain activities. Phys Rev E 91, 010701 Hansen ECA, Battaglia D, Spiegler A, Deco G, Jirsa VK (2015) Functional connectivity dynamics: Modeling the switching behavior of the resting state. Neuroimage 105, 525-531 Proix T, Bartolomei F, Chauvel P, Bernard C, Jirsa VK (2014) Permittivity coupling across brain regions determines seizure recruitment in partial epilepsy. The Journal of Neuroscience 34(45):15009 –15021 Woodman MM, Pezard L, Domide L, Knock S, Sanz Leon P, Mersmann J, McIntosh AR, Jirsa VK (2014) Integrating Neuroinformatics Tools in The Virtual Brain. Front. Neuroinform. 8:36. doi: 10.3389/fninf.2014.00036


Laboratory: INMED/INSERM U1249 Head of the laboratory: Dr Rosa Cossart Team name: Molecular basis and physiopathology of cerebral cortical developmental disorders. Team leader(s): Dr Carlos Cardoso First name and last name of the proposed PhD supervisor(s): Dr Alfonso Represa (HDR), Dr Françoise Watrin, Dr Jean-Bernard Manent (HDR) Title of the proposed PhD research project: Deciphering pathomechanisms of epileptogenic cortical malformations Names and PhD year of the currently supervised PhD students: none Names and dates of the previously supervised PhD students: Shirley Beguin (2007-2011); Ludovic Petit (2009-2014); Fanny Martineau (2013-2017); Véronique Brévaut-Malaty, praticien hospitalier (2011-2017) Publications of the previously supervised PhD students (underline the names): Martineau F et al., bioRxiv. 2017 doi: 10.1101/229948 ; Petit LF et al., Annals of Neurology. 2014 doi: 10.1002/ana.24237 ; Beguin S et al., Cerebral Cortex. 2013 doi: 10.1093/cercor/bhs138 ; Carabalona A, Beguin S et al., Human Molecular Genetics. 2012 doi: 10.1093/hmg/ddr531 ; Marissal T, +3authors, Petit LF et al., Nature Communications. 2012 doi: 10.1038/ncomms2318 ; Manent JB, Beguin S et al., European Journal of Neuroscience. 2011 doi: 10.1111/j.1460-9568.2011.07867.x


Laboratory: INMED Head of the laboratory: Rosa Cossart Team name: The neural basis of sensorimotor learning Team leader: Ingrid Bureau (IB) /David Robbe (DR) First name and last name of the proposed PhD supervisor(s): IB and DR (cosupervision) Title of the proposed PhD research project: Sensing to move. Investigating the role of the cortico-striatal system in whisker-guided locomotion. Names and PhD year of the currently supervised PhD students: Mostafa Safaie (2nd Year, with DR) Names and dates of the previously supervised PhD students: 1. Carola Sales Carbonell (2012-2016, with DR) 2. Melissa Erlandson, (2014-2017,with IB) 3. Laetitia Lalla (2014-2017, with DR) 4. Maxime Fieschi, (2009-2013,with IB) Publications of the previously supervised PhD students (underline the names): 1. Sales-Carbonell C, Taouali W, Khalki L, Pasquet M, Petit LF, Moreau T, Rueda-Orozco PE and Robbe D. No discrete start/stop signals in the dorsal striatum of mice performing a learned action. In review at Current Biology. 2. Camon J, Hugues S, Erlandson M, Robbe D, Lagou S, Marouane E, Bureau I. The timing of sensory-guided behavioral response is represented in the mouse primary somatosensory cortex. in revision at Cerebral Cortex. 3. Lalla L, Rueda Orozco PE, Jurado-Parras M-T, Brovelli A, Robbe D (2017) Local or Not Local: Investigating the Nature of Striatal Theta Oscillations in Behaving Rats. eNeuro. 4. Erlandson M, Manzoni O,Bureau I (2015) The functional organization of neocortical networks investigated in slices with local field recordings and laser scanning photostimulation. Plos One 5. Sales-Carbonell C, Rueda-Orozco PE, Soria-Gómez E, Buzsáki G,Marsicano G, Robbe D (2013) Striatal GABAergic and cortical glutamatergic neurons mediate contrasting effects of cannabinoids on cortical network synchrony. Proc Natl Acad Sci U S A. 6. Rosselet C, Fieschi M, Hugues S, Bureau I (2011). Associative learning changes the organization of functional excitatory circuits targeting the supragranular layers of mouse barrel cortex. Frontiers in Neural Circuits


Laboratory: INSERM UMR-S 1251 - Marseille Medical Genetics Center Head of the laboratory: Nicolas LEVY Team name: Human Neurogenetics Team leader(s): Laurent VILLARD First name and last name of the proposed PhD supervisor(s): Laurent VILLARD Title of the proposed PhD research project: Characterization of a mouse model for Ohtahara syndrome and pharmacological interventions. Names and PhD year of the currently supervised PhD students: No current PhD student directly supervised by the PI Names and dates of the previously supervised PhD students: Affef ABIDI, defended in 2016 Nancy CHOUCAIR, defended in 2013 Bilal EL WALY, defended in 2012 Marie-Reine HADDAD, defended in 2009 Vincent CANTAGREL, defended in 2007 Véronique SAYWELL, defended in 2006 Publications of the previously supervised PhD students (underline the names): Heterogeneity of FHF1 related phenotypes: novel case with early onset severe attacks of apnea, partial mitochondrial respiratory chain complex II deficiency, neonatal onset seizures without neurodegeneration. Villeneuve N, Abidi A, Cacciagli P, Mignon-Ravix C, Chabrol B, Villard L, Milh M. Eur J Paediatr Neurol. 2017 Sep;21(5):783-786. Early-onset epileptic encephalopathy as the initial clinical presentation of WDR45 deletion in a male patient. Abidi A, Mignon-Ravix C, Cacciagli P, Girard N, Milh M, Villard L. Eur J Hum Genet. 2016 Apr;24(4):615-8. A Kv7.2 mutation associated with early onset epileptic encephalopathy with suppression-burst enhances Kv7/M channel activity. Devaux J, Abidi A, Roubertie A, Molinari F, Becq H, Lacoste C, Villard L, Milh M, Aniksztejn L. Epilepsia 2016, 57(5):e87-93. Epileptic patients with de novo STXBP1 mutations: Key clinical features based on 24 cases. Di Meglio C, Lesca G, Villeneuve N, Lacoste C, Abidi A, Cacciagli P, Altuzarra C, Roubertie A, Afenjar A, Renaldo-Robin F, Isidor B, Gautier A, Husson M, Cances C, Metreau J, Laroche C, Chouchane M, Ville D, Marignier S, Rougeot C, Lebrun M, de Saint Martin A, Perez A, Riquet A, Badens C, Missirian C, Philip N, Chabrol B, Villard L, Milh M. Epilepsia. 2015 Dec;56(12):1931-40. A recurrent KCNQ2 pore mutation causing early onset epileptic encephalopathy has a moderate effect on M current but alters subcellular localization of Kv7 channels. Abidi A, Devaux JJ, Molinari F, Alcaraz G, Michon FX, Sutera-Sardo J, Becq H, Lacoste C, Altuzarra C, Afenjar A, Mignot C, Doummar D, Isidor B, Guyen SN, Colin E, De La Vaissière S, Haye D, Trauffler A, Badens C, Prieur F, Lesca G, Villard L, Milh M, Aniksztejn L. Neurobiol Dis. 2015 Aug;80:80-92. Variable clinical expression in patients with mosaicism for KCNQ2 mutations. Milh M, Lacoste C, Cacciagli P, Abidi A, Sutera-Sardo J, Tzelepis I, Colin E, Badens C, Afenjar A, Coeslier AD, Dailland T, Lesca G, Philip N, Villard L. Am J Med Genet A. 2015 Oct;167A(10):2314-8. Evidence that homozygous PTPRD gene microdeletion causes trigonocephaly, hearing loss, and intellectual disability. Choucair N, Mignon-Ravix C, Cacciagli P, Abou Ghoch J, Fawaz A, Mégarbané A, Villard L, Chouery E. Mol Cytogenet. 2015 Jun 16;8:39. Contribution of copy number variants (CNVs) to congenital, unexplained intellectual and developmental disabilities in Lebanese patients. Choucair N, Ghoch JA, Corbani S, Cacciagli P, Mignon-Ravix C, Salem N, Jalkh N, El Sabbagh S, Fawaz A, Ibrahim T, Villard L, Mégarbané A, Chouery E. Mol Cytogenet. 2015 Apr 9;8:26. Intragenic rearrangements in X-linked intellectual deficiency: results of a-CGH in a series of 54 patients and identification of TRPC5 and KLHL15 as potential XLID genes. Mignon-Ravix C, Cacciagli P, Choucair N, Popovici C, Missirian C, Milh M, Mégarbané A, Busa T, Julia S, Girard N, Badens C, Sigaudy S, Philip N, Villard L. Am J Med Genet A. 2014 Aug;164A(8):1991-7. Nhej1 Deficiency Causes Abnormal Development of the Cerebral Cortex. El Waly B, Buhler E, Haddad MR, Villard L. Mol Neurobiol. 2015 Aug;52(1):771-82. Disruption of the ATP8A2 gene in a patient with a t(10;13) de novo balanced translocation and a severe neurological phenotype. Cacciagli P, Haddad MR, Mignon-Ravix C, El-Waly B, Moncla A, Missirian C, Chabrol B, Villard L. Eur J Hum Genet. 2010 Dec;18(12):1360-3.

Deletion of YWHAE in a patient with periventricular heterotopias and pronounced corpus callosum hypoplasia. Mignon-Ravix C, Cacciagli P, El-Waly B, Moncla A, Milh M, Girard N, Chabrol B, Philip N, Villard L. J Med Genet. 2010 Feb;47(2):132-6. Spatiotemporal expression in mouse brain of Kiaa2022, a gene disrupted in two patients with severe mental retardation. Cantagrel V, Haddad MR, Ciofi P, Andrieu D, Lossi AM, Maldergem Lv, Roux JC, Villard L. Gene Expr Patterns. 2009 Sep;9(6):423-9. Characterization of a de novo balanced translocation in a patient with moderate mental retardation and dysmorphic features. Haddad MR, Mignon-Ravix C, Cacciagli P, Mégarbané A, Villard L. Eur J Med Genet. 2009 Jul-Aug;52(4):211-7. Truncation of NHEJ1 in a patient with polymicrogyria. Cantagrel V, Lossi AM, Lisgo S, Missirian C, Borges A, Philip N, Fernandez C, Cardoso C, Figarella-Branger D, Moncla A, Lindsay S, Dobyns WB, Villard L. Hum Mutat. 2007 Apr;28(4):356-64. Disruption of a new X linked gene highly expressed in brain in a family with two mentally retarded males. Cantagrel V, Lossi AM, Boulanger S, Depetris D, Mattei MG, Gecz J, Schwartz CE, Van Maldergem L, Villard L. J Med Genet. 2004 Oct;41(10):736-42. Metabolic fingerprints of altered brain growth, osmoregulation and neurotransmission in a Rett syndrome model. Viola A, Saywell V, Villard L, Cozzone PJ, Lutz NW. PLoS One. 2007 Jan 17;2(1):e157. Brain magnetic resonance study of Mecp2 deletion effects on anatomy and metabolism. Saywell V, Viola A, Confort-Gouny S, Le Fur Y, Villard L, Cozzone PJ. Biochem Biophys Res Commun. 2006 Feb 17;340(3):776-83. Mecp2 deficiency disrupts norepinephrine and respiratory systems in mice. Viemari JC, Roux JC, Tryba AK, Saywell V, Burnet H, Peña F, Zanella S, Bévengut M, Barthelemy-Requin M, Herzing LB, Moncla A, Mancini J, Ramirez JM, Villard L, Hilaire G. J Neurosci. 2005 Dec 14;25(50):11521-30.

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