information provided is for educational purposes only. “nitric oxide is the molecule of life.”...

Information provided is for Educational Purposes Only.

“Nitric Oxide is the Molecule of Life.”– Dr.Abbas Qutab M.D., Ph.D.

What is Nitric Oxideand Why Does the

Body Need It?

by Dr. Thomas Burke


Body Need It?

by Dr. Thomas Burke



What is Nitric Oxide (NO)?What is Nitric Oxide (NO)?

• NO is one of the most powerful, endogeneous vasodilators.

• Vasodilators improve circulation throughout the body.

• In 1998 The Nobel Prize in Physiology or Medicine was awarded to 3 Americans for their discoveries concerning the Nitric Oxide molecule in the cardiovascular system.

Robert F. Furchgott

Louis J. Ignarro

Ferid Murad



Why does the body need NO?Why does the body need NO?

• The Answer: Better Circulation

– Dilates existing vessels; arterioles, venules and lymphatics.

– Angiogenesis - the growth of new blood and lymph vessels.

– Decreases edema and swelling.– Increases nutritional flow to cells.– Increases antibiotic delivery and action.– Restores blood flow to nerves.



What about Diabetics and NO?What about Diabetics and NO?

• Diabetic patients have less NO in their bodies than those who are not diabetic.

– Reduced production of Nitric Oxide in the body.

– Can’t release Nitric Oxide as well as healthier people do.

– High blood glucose destroys Nitric Oxide.– Diabetic patients have many different

circulation problems.



Circulation is CriticalCirculation is Critical

• Better circulation is critical to helping patients with diabetes or other health challenges.– Decrease pain, especially ischemic

pain from inadequate blood supplies to organs or parts of the body.

– Restore sensation to help prevent falls.

– Assists in the recovery of wounds.



Supporting ResearchSupporting Research

• Who says Nitric Oxide may be important regarding falls with the elderly?– Diabetes Mellitus is associated with

an increases risk of falls in elderly residents of a long-term care facility.

– Maurer MS, Murcham J, Cheng H

– Gerontol A Biol Sci Med Sci. 2005;60:1157-62



Nitric Oxide, Circulation and WoundsNitric Oxide, Circulation and Wounds

• Diabetic Ulcers

• Pressure Ulcers

• Venous Stasis Ulcers

• Arterial Ulcers

• Gangrene

• Post-op



Supporting ResearchSupporting Research

• Who says Nitric Oxide may be important in wound healing?– Shaffer MR, Tantry U, Gross SS,

Wasserburg HL, Barbul A.

– Nitric Oxide regulates wound healing.

– J Surg Red. 1996;63:237-240



Additional Research

• Raynaud’s Syndrome– Tucker AT, Pearson RM, Cooke

ED, Benjamin N.

– Effect of Nitric Oxide generating system on microcirculatory blood flow in skin of patients with severe Raynaud’s Syndrome: a randomised trial.

– Lancet 1999 Nov 13;354(9191):1670-5

• NO and Pain Relief– Ferreira SH, Duarte ID,

Lorenzetti BB.

– The molecular mechanism of action of peripheral Morphine Analgesia: stimulation of the cGMP system via Nitric Oxide release.

– Eur J Pharmacol 1991;201:121-122



Additional Research• Fibromyalgia

– Jeschonneck M, Grohmann G, Hein G, Sprott H.

– Abnormal microcirculation and temperature in skin above tender points in patients with fibromyalgia.

– Rheumatology (Oxford) Aug. 2000;39(8):917-21

• L-Arginine– Roger RH, Bode-Boger SM,

Thiele W, Creutzig A, Alexander K, Frolich JC.

– Restoring vascular Nitric Oxide formation by L-Arginine improves the symptoms of intermittent claudication in patients with peripheral arterial occlusive disease.

– J Am Coll Cardiol 1998;32:1336-44



Additional Research• Plastic Surgery

– Um SC, et al;

– Involvement of Nitric Oxide in survival of random pattern skin flap.

– Plast Reconstr Surg 1998;101:785-92

• Fractures– Diwan AD, Wang MX, Jang D,

Zhu W, Murrell GA.

– Nitric Oxide modulates fracture healing.

– J Bone Miner Red. 2000;15:324-51

• Tendons– Murrell GA, Szabo C, Hannafin JA, Jang D,

Dolan MM, Deng XH, Murrell DF, Warren RF.

– Modulation of tendon healing by Nitric Oxide.

– Inflamm Res. 1997;46:19-27



Increased Circulation Responsive Conditions

• Inflammation/Infection– Bursitis– Osteoarthritis– Tendonitis– Plantar Facitis– Lateral Epichondylitis– Neuritis– Synovitis– Bell’s Palsy– Cellulitis– Ostemoelitis (IV Antibiotics)

• Range of Motion Deficits– Frozen Shoulder– Contractures

• Orthopedic– Non-Union/Jones Fractures– Degenerative Disc

• Chronic Wounds– Venous, Pressure Ulcers (Arterial)– Diabetic Wounds– Post Op– PVD



Increased Circulation Responsive Conditions

• Pain– Fibromyalgia– Neuralgia– Neuropathic Pain– Ischemic Pain– Chronic Pelvic Pain

• Nerve Entrapments– TMJ– Carpal Tunnel Syndrome– Tarsal Tunnel

• Swelling– Edema– Lymphedema– Sprains and Strains

• Post Operative– Reduce Swelling and Pain– Speed Recovery– Reduce Adhesions/Scarring



NO and Health Benefits SummaryNO and Health Benefits Summary

• Increased Circulation through Nitric Oxide which will…– Reduce pain and restore sensation.

– Improve gait and balance.

– Help with would recovery.

– Assist in fracture/tendon recovery.

– Great deal of research to support benefits.

– Assist in Plastic Surgery recovery.

– Workman’s compensation reduced.




Body Need It?

by Dr. Thomas Burke


Body Need It?

by Dr. Thomas Burke

information provided is for educational purposes only. “nitric oxide is the molecule of life.”...

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