inhibitors of cell wall and protein synthesis in bacteria bds sem iii 20-2-15
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Inhibitors of Cell wall and Protein Synthesis
BDS Semester III
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Objectives
• By the end of this lecture you should be able to:
• Classify the major cell wall and protein synthesis inhibitors
• Understand their mechanism of action.
• Explain resistance mechanisms against these antimicrobials.
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Carbapenems
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Limitations of Penicillins
• Limited effectiveness against many gram negative rods
• Hydrolysis by gastric acid
• Inactivation by beta- lactamases
• Hypersensitivity reactions
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Carbapenems
•Monobactam
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1. Aminoglycosides
2. Tetracyclins
Inhibition of Protein Syntesis
1. Chloramphenicol2. Erythromycin3. Clindamycin4. Linezolid5. Streptogramins
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