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Innovative Health and Wellbeing products with Ectoin ® Nature provides the idea, we add the know-how. Product Guide bitop.de I ectoin.net Interested in a license? Please contact our business development team bitop AG Stockumer Str. 28 58453 Witten Germany Phone: +49 2302 914 40 0 Email: [email protected]

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Innovative Health and Wellbeing products with Ectoin®

Nature provides the idea, we add the know-how.

Product Guide

bitop.de I ectoin.net

Interested in a license? Please contact our business development team

bitop AG Stockumer Str. 28 58453 Witten Germany

Phone: +49 2302 914 40 0 Email: [email protected]

2 3

bitop AG, a German company, is focused on the manufacturing and utilization of natural protective molecules, the so-called extremolytes.

For more than 20 years, bitop has explored and valida ted Ectoin®, a naturally-derived molecule with excellent membrane-stabilizing and inflammation-reducing prop-erties, for human use. Build on this experience, a portfolio of unique and natural OTC medical devices and cosmetics has been developed. bitop’s greatest value lies in the scientifically proven efficacy of its IP-protected pro ducts and the natural and preservative-free formulations.

bitop offers its ready-to-sell formula-tions on a B2B licensing basis to pharma-c eutical companies globally.

Numerous Ectoin®-containing products already proved their efficacy and marketability successfully on the mar-ket: Health and wellbeing products for treatment and symptom alleviation of diverse skin diseases, cough and cold, allergies and dry epithelia are marketed under brands of experienced pharmaceutical partners in more than 45 countries worldwide by now. Currently, bitops portfolio comprises more than 20 medical devices which are ready for licensing.

Now, bitop also enters the oncology supportive care market and strives to broaden its product range with an anti-pollution portfolio and animal health products.

bitop is constantly seeking for new, strong licens-ing partners to spread the availability and variety of Ectoin®-containing products throughout the world.

bitop also provides Ectoin® to the cosme-tic industry where it is highly valued as an innovative ingredient for anti-aging formulations and sun care products.

With Glycoin® natural and 28Extremoin®, two more inno-vative cosmetic actives are available.

bitop AG The Extremolyte Company

From extremophilic microorganisms to ready-to-sell products

▶ Are you interested in licensing Ectoin®-containing products or do you want to create your own product formulation with Ectoin®? Our experienced research and development team is keen to work also on customer-specific products. Please contact us under: [email protected]

bito

p AG

5

Extremolytes are accumulated inside of specialized microorganisms, the so-called extre mo philes, which thrive under extreme environmental conditions.

These small protective molecules have large effects: they stabilize and maintain biological structures and protect the extremophiles from environmental stresses such as extreme temperature variations, high salt concentra-tions, strong UV radiation, or drought.

One of the most abundant extremolytes in nature is Ectoin®. It was found in 1985 inside of halophilic (salt-loving) bacteria in Wadi El Natrun, a salt lake in Egypt, and is a cyclic amino acid derivative.

The protective characteristics of Ectoin® have been made available for human use, utilizing highly specialized manu-facturing processes.

Ectoin® – Protection designed by nature

Ectoin® – Mode of action

Geysir

Salt Lake

Desert

Ice Desert

Ectoin®

• enhances the binding strength between water molecules

• increases the number of neighboring water molecules in water layers

• strengthens the water structure around the Ectoin® molecule

The Ectoin® Hydro Complex – Influence on water structure

Ectoin® is a so-called kosmotropic molecule. Kosmotropic molecules contribute to the stability and structure of water molecules.

Legend

Ectoin®water molecule

Ecto

in®

6 7

Due to a physical principle called „preferential exclu-sion“, the stabilization of water also leads to the stabi-lization of surrounding biomolecules like cell membranes and proteins.

Transferred to a biological system, Ectoin® surrounds itself but also neighboring cell membranes or proteins with a protective water layer. bitop named this unique structure „Ectoin® Hydro Complex“.

Living organisms have to deal with diverse stress factors, e. g. allergens, air pollu tion, heat, dryness or UV light, anytime during their life.

Figure 2: Ectoin® stabilizes cell membranes

without Ectoin® with Ectoin®

without Ectoin® with Ectoin®

without Ectoin® with Ectoin®

Figure 1: Ectoin® stabilizes biomolecules (proteins)

Increased fluidity and stabilization of cell membranes

Stress factors trigger and harm cell membranes and lead to an increased release of inflammation mediators. Hence, stress factors cause inflammations.

Due to the formation of the Ectoin® Hydro Complex, Ectoin® stabilizes cell mem branes and thereby protects human cells against external stress factors.

Figure 3: Ectoin® reduces inflammations

Release of stress mediators intercelluar

The Ectoin® Hydro Complex – Stabilization of biomolecules and cell membranes The Ectoin® Hydro Complex – Reduction of inflammation

Ectoin® – a unique safety profile

• Ectoin® is not binding to human receptors.

• Ectoin® is not entering into human cells.

• Ectoin® does not act pharmaceutical.

Positive impact on human epithelia Ectoin® leads to a reduction of inflammation

With Ectoin®

• the negative impact of stress factors is reduced,

• less inflammation mediators are released and

• the cells are able to regenerate from previous stress.

Ectoin® – Mode of actionEctoin® – Mode of action

protein

Legend

lipid bilayer stress factor stress mediatorEctoin®water molecule

Ecto

in®

Ecto

in®

8 9

Dry Epithelia Supportive CareAirway DiseasesCough and ColdDermatology Allergy

Medical devices with Ectoin®

Most of the common diseases today – e.g. cough and cold, allergies, eczema, dry eyes – and even more severe con-ditions such as mucositis, COPD, or asthma are caused by disturbed epithelia or by an instable skin barrier. These diseases are even self-enforcing if the epithelia are not stabilized.

Our Ectoin®-containing medical devices are dedicated for stabilization of epithelia as well as the skin barrier.

Based on this effect, the products reduce inflammations and alleviate well-known symptoms effectively but on a natural way. Due to their excellent safety profile they can be used for treatment of patients of all ages, from infants to elderly.

Further outstanding features of our healthcare products are their IP protection for the most important global markets and their scientifically proven efficacy.

Human Health and WellbeingEctoin® – Three dimensional mode of action

Stabilization of cell membranes and biomolecules

Reduction of inflammation

Symptom relief

Influence on water structure

Ecto

in®

Ecto

in®

10 11

ClaimsNasal balm for treatment and prevention of dry and sore nasal mucosa and skin around the nostrils.

• Supports the healing process of sore nasal mucosa and skin around the nostrils.

• Reduces inflammations of nasal mucosa and skin around the nostrils and reduces redness.

• Increases skin elasticity and thereby protects the skin around the nostrils from damage due to extensive use of tissues.

• Relieves itching, burning and crust formation inside the nose.

• Supports free breathing.

IngredientsEctoin®, (Mint and Salvia Oil), Aqua, Hydrogenated Lecithin, Ceramide-3, Squalane, Olea Europaea Fruit Oil, Caprylic/Capric Triglyceride, Butyros-permum Parkii Butter, Oryza Sativa (Rice) Bran Cera, Carbomer, Xanthan Gum, Sodium Carbom-er, Cardiospermum Halicacabum Flower/Leaf/Vine Extract, Glycine, Alanine, Pentylene Glycol, Butylene Glycol, Hydroxyethylcellulose, Glycerine, Hydroxyphenyl Propamidobenzoic Acid.

Suitable forInfants, children, adolescents and adults.

Dosage FormsAluminum tube (3 ml, 5 ml)

Effective relieve for dry and irritated nasal mucosa and skin surrounding nostrils

Status (EU): Medical Device Class I (in process of CE registration)

Study Overview

• Several studies with diverse Ectoin®- containing creams show great efficacy in reduction of skin redness and stabilization of the skin barrier.

Ectoin® Nasal BalmEctoin® Rhinitis Nasal Spray

ClaimsNasal Spray for treatment and prevention of non-allergic rhinitis or rhinosinusitis symptoms.

• Reduces inflammations of disturbed nasal mucosa and sinuses caused by rhinitis and rhinosinusitis (common cold).

• Alleviates typical symptoms such as dry and wound nasal epithelium, sneezing, itching and crust formation.

• Decongests the nose and sinuses on a natural way.

• Supports the reduction of the use of decongestant nasal sprays.

IngredientsEctoin®, Sea Salt, Phosphate Buffer, Water.

Suitable forInfants, children, adolescents and adults.

Dosage Forms20 ml bottle with dosage pump

Natural treatment and relief of non-allergic rhinitis and rhinosinusitis

Status (EU): Medical Device Class I

Study OverviewEichel et. al., 2013

• Tested against German OTC bestseller: Ectoin® Rhinitis Nasal Spray is as effective as Sinupret® forte.

• Significant reduction of primary symptoms during acute rhinosinusitis.

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ClaimsMouth and Throat Spray for treatment and pre-vention of dry and irritated epithelia in mouth and throat.

• Reduces sore throat, hoarseness, cough, and pain on swallowing.

• Helps to reduce the duration of a sore throat/hoarseness by reduction of bacterial ingression due to the modified Ectoin® Hydro Complex and the stabilized mucosal barrier structure.

• Reduces allergen ingression and therefore soothes mucous membrane symptoms caused by pollen allergies.

• Supports reduction of inflammations of the mucous membranes in mouth and throat.

IngredientsEctoin®, Sea Salt, Phosphate Buffer, Xylitol, Sodium Cyclamate, Caprylic Acid, Mint Oil, Salvia Oil, Water.

Suitable forChildren older than two years, adolescents and adults.

Dosage Forms20 ml bottle with dosage pump (3K)

New generation of sore throat treatment

Status (EU): Medical Device Class I

Study OverviewMüller et. al., 2016

• Superior efficacy in treating acute pharyn gitis and/or laryngitis compared to mineral salt pastilles (Emser® Pastillen) was shown with the product “Ectoin® Mouth and Throat Spray 1 %”.

ClaimsMouth and Throat Spray for treatment and prevention of dry and irritated epithelia in mouth and throat.

• Relieves sore throat, hoarseness, cough, and pain on swallowing.

• Supports reduction of inflammations of the mucous membranes in mouth and throat.

• Prevents irritations of mucous membranes caused by cold air or air conditioning.

• Soothes itchy palate caused by allergies.

• Supports regeneration of dry and irritated membranes.

IngredientsEctoin®, Sea Salt, Phosphate Buffer, Mint Oil, Xylitol, Water.

Suitable forChildren older than two years, adolescents and adults.

Dosage Forms20 ml bottle with dosage pump (3K)

Effective treatment and prevention of sore throat and hoarseness

Status (EU): Medical Device Class I

Study OverviewMüller et. al., 2016

• Tested against mineral salt pastilles: proven superior efficacy in treating acute pharyngitis and/or laryngitis compared to Emser® Pastillen.

Ectoin® Mouth & Throat Spray + CA/XYEctoin® Mouth & Throat Spray 1 %

Also

suitable for

treatment of

allergic

symptoms

Also

suitable for

treatment of

allergic

symptoms

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ClaimsLozenges for treatment and prevention of com-mon cold symptoms, dry mouth and throat, and hoarseness due to voice overuse.

• Reduces inflammations of the mucous mem-branes in mouth and throat.

• Relieves hoarseness, sore throat, or pain on swallowing.

• Stabilizes the mucous membranes and thus reduces the danger of a bacterial or viral infec-tion in mouth and throat.

• Reduces and prevents irritations of the mucous membranes such as voice fatigue, tickly throat, or dryness.

• Hydrates dry epithelia and supports their regeneration.

IngredientsEctoin®, Isomalt, Sucralose, Menthol, Citric Acid, Lemon Mint Flavour (containing tocopherol), Honey Flavour (containing polyethylene glycol), Safflor Concentrate, Glucose Syrup, Water.

Suitable forChildren older than 6 years, adolescents and adults.

Dosage FormsBlister strips containing 10 lozenges à 2.3 g

Protection shield against common cold symptoms, dry mouth and hoarseness

Status (EU): Medical Device Class I

Study Overview

• Studies with Ectoin® Lozenges show great efficacy in reducing sore throat and other pharyngitis symptoms.

ClaimsLozenges for treatment and prevention of com-mon cold symptoms, dry mouth and throat, and hoarseness due to voice overuse.

• Reduces inflammations of the mucous mem-branes in mouth and throat.

• Helps to relieve hoarseness, sore throat, or pain on swallowing.

• Stabilizes the mucous membranes and thus reduces the danger of a bacterial or viral infec-tion in mouth and throat.

• Reduces and prevents irritations of the mucous membranes such as voice fatigue, tickly throat, or dryness.

• Hydrates dry epithelia and supports their regeneration.

IngredientsEctoin®, Wildberry Flavour, Menthol, Grape Skin Extract, Citric Acid, Acesulfame K, Gum Arabic, Maltitol, Sorbitol, Water, Vegetable Oil, Beeswax.

Suitable forChildren older than 6 years, adolescents and adults.

Dosage FormsBlister strips containing 10 lozenges à 1 g or 2 g

Protection shield against common cold symptoms, dry mouth and hoarseness

Status (EU): Medical Device Class I

Study Overview

• Tested against German bestseller (GeloRevoice®) and salt water gargling solution.

• Significant improvement of sum of pharyn gitis symptoms (pain on swallow-ing, tickle in the throat and hoarseness).

Ectoin® Lozenges HC (Hard Candies)Ectoin® Lozenges (Gum Arabic Pastilles)

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ClaimsNasal Spray for treatment and prevention of allergic rhinitis symptoms.

• Reduces allergen induced inflammations of the nasal mucosa.

• Alleviates allergic symptoms (itchy and runny nose, sneezing, nasal congestion).

• Supports the regeneration process of irritated nasal mucosa caused by allergens.

• Reduces harmful influences of allergens and airborne particles.

IngredientsEctoin®, Sea Salt, Water.

Suitable forInfants, children, adolescents and adults.

Dosage Forms20 ml solution in bottle with dosage pump

The innovation for treatment and prevention of allergic rhinitis symptoms

Status (EU): Medical Device Class I

ClaimsInhalation solution for supportive treatment to reduce inflammations of the airways in case of bronchitis, asthma or Chronic Obstructive Pulmonary Disease (COPD).

• For supportive treatment and symptom allevia-tion of diseases of the airways, such as allergic or non-allergic asthma, or Chronic Obstructive Pulmonary Disease (COPD).

• For supportive treatment and prevention of bronchitis symptoms.

• Protects and moisturizes the mucosa of the airways (e. g. when exposed to particulate matter, pollen, dust or to dry air in heated or air conditioned rooms).

• Prevents symptoms of allergic reactions of the respiratory system while suffering from e. g. allergic asthma, housedust allergy, etc.

IngredientsEctoin®, Sea Salt, Water.

Suitable forNewborn, infants, children, adolescents and adults.

Dosage FormsSingle-dose units with 2.5 ml solution for jet, mesh, or ultrasound nebulizers

Effective bronchitis treatment and symptom reduction in asthma and COPD

Status (EU): Medical Device Class IIa

Study OverviewUnfried et. al., 2010; Sydlik et. al., 2013; Unfried et. al., 2014; Unfried et. al., 2016

• Tested in patients with acute infection of the respiratory system, asthma and bronchitis.

• Proven reduction of lung inflammation due to lifelong exposure to environmental air pollution.

• Several preclinical and clinical studies prove significant reduction of inflam­mation markers after treatment with Ectoin®.

Ectoin® Allergy Nasal Spray 2 %Ectoin® Inhalation Solution

Also

suitable during

cough and cold

and for treat-

ment of allergic

symptoms

Study OverviewWerkhäuser et. al., 2014; Sonnemann et. al., 2014; Eichel et. al., 2014; Abdulkerimov et. al., 2016; Minaeva et. al., 2015

• Tested against standard OTC drugs and placebo: As effective as cromoglicic acid, beclomethasone or azelastine-containing nasal sprays.

• Seven studies including nearly 400 patients prove: signi ficant improvement of local symptoms and excellent safety profile.

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ClaimsEye drops for treatment and prevention of allergic conjunctivitis symptoms.

• Reduces allergen induced inflammations of the conjunctiva.

• Alleviates allergic symptoms (red, itchy and watery eyes).

• Protects against the harmful influences of allergens.

• Supports the regeneration process of irritated and sensitive conjunctiva.

IngredientsEctoin®, Sodium Chloride, Hydroxyethyl Cellulose, Citrate Buffer, Water.

Suitable forNewborn, infants, children, adolescents and adults.

Dosage Forms0.5 ml solution in single-dose ampoules or 10 ml in a multidose dropper (OSD or 3K)

The innovation for treatment and prevention of allergic conjunctivitis symptoms

Status (EU): Medical Device Class Is

Study OverviewSalapatek et. al., 2011; Werkhäuser et. al., 2014; Skrypnyk 2015; Allegri et. al., 2014; Drozhzhina and Troichenko, 2015

• Tested against standard OTC drugs and placebo: as effective as azelastine and ketotifen-containing eye drops.

• Excellent tolerability and safety proven in children and adults.

ClaimsNasal douche for prevention and treatment of rhinitis and rhinosinusitis symptoms.

• Reduces inflammations of disturbed mucosa in the nose.

• Alleviates symptoms such as dry and sore nasal mucosa, sneezing, itching, congestion, and crust formation.

• Reduces harmful influences of allergens and airborne particles.

• Supports the regeneration process of irritated nasal mucosa.

• Gently cleans nasal cavities.

• Provides essential moisture and prevents dehydration.

• Helps to decongest the nasal mucosa on a natural way.

IngredientsEctoin®, Sea Water, Purified Water.

Suitable forInfants, children, adolescents and adults.

Dosage Forms50 ml, 100 ml or 125 ml solution in a bag on valve system

Symptom reduction and cleansing during allergic rhinitis and common cold

Status (EU): Medical Device Class I (in process of CE registration)

Ectoin® Nasal DoucheEctoin® Allergy Eye Drops 2 %

Also

suitable for

treatment

during cough

and cold

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ClaimsEye drops for treatment and prevention of dry eyes symptoms.

• Moisten dry and irritated eyes.

• Reduce burning and itching.

• Stabilize the lipid layer of the tear film and reduce further dehydration.

• Protect ocular cells from hyperosmolarity.

• Aid cell regeneration.

• Suitable for contact lens wearers.

IngredientsEctoin®, Sodium Hyaluronate, Sodium Chloride, Water, Citrate Buffer.

Suitable forNewborn, infants, children, adolescents and adults.

Dosage Forms0.35 ml solution in single-dose ampoules or 10 ml in a multidose dropper (3K or OSD)

Tear film stabilization, itch reduction and moistening of dry eyes

Status (EU): Medical Device Class IIa

Study OverviewDwivedi et. al., 2014 (1); Dwivedi et. al., 2014 (2); Drozhzhyna et. al., 2015; Veselovska et. al., 2016

• Studies with other Ectoin®-containing formulations show significant improve-ment of tear-break-up time.

• Several preclinical and clinical studies prove: Ectoin® effectively stabilizes lipid layers and improves membrane fluidity.

ClaimsEye drops for treatment and prevention of dry eyes symptoms.

• Moisten dry eyes and prevent from further dehydration.

• Reduce inflammations caused by an irritated or dry conjunctiva.

• Alleviate symptoms of dry eyes such as burning, dryness, itching etc.

• Support the regeneration process of dry and irritated conjunctivas.

• Stabilize the lipid layer of the tear film.

• Suitable for sensitive eyes and contact lens wearers.

IngredientsEctoin®, Hydroxyethyl Cellulose, Sorbitol, Water, Citrate Buffer.

Suitable forNewborn, infants, children, adolescents and adults.

Dosage Forms0.5 ml solution in single-dose ampoules or 10 ml in a multidose dropper (OSD)

Protection from dry and itchy eyes

Status (EU): Medical Device Class IIa

Study OverviewDwivedi et. al., 2014 (1); Dwivedi et. al., 2014 (2); Drozhzhyna et. al., 2015; Veselovska et. al., 2016

• Tested against HA-containing eye drops: Non-inferiority proven.

• Significant improvement of tear­break­up time.

Ectoin® Sicca Eye Drops + HA 0.2 %Ectoin® Sicca Eye Drops

Dry

Epit

helia

Dry

Epit

helia

22 23

ClaimsMouth wash for treatment and prevention of dry mouth and other symptoms of an inflamed oral mucosa.

• Supports reduction of inflammations of oral mucous membranes (oral mucositis or stomatitis).

• Helps to reduce the incidence of inflamed oral mucosa.

• Alleviates and prevents symptoms such as sore mouth, redness and burning of the oral mucosa.

• Helps to relieve pain in the mouth and therefore eases eating, drinking, and talking.

• Moistens dry mouth and prevents from further dehydration.

IngredientsSingle-Doses: Ectoin®, Hydroxyethyl Cellulose, Phosphate Buffer, Xylitol, Water. Multi-Doses: Ectoin®, Succinic Acid, Hydroxyethyl Cellulose, Xylitol, Sodium Benzoate, Sorbic Acid, Natural Orange Flavour, Sodium Hydroxide, Water.

Suitable forInfants, children, adolescents and adults.

Dosage FormsSingle-Doses: 10, 20 or 30 single-dose ampoules with 5 ml solution (preservative-free) Multi-Dose: PET bottle with dosing cap (50 ml or 195 ml)

Effective reduction of redness and burning

Status (EU): Medical Device Class I

ClaimsNasal spray for symptomatic treatment and prevention of the dry nose syndrome.

• Alleviates typical symptoms of the dry nose syndrome (crust formation, itching in the nose).

• Reduces inflammations caused by disturbed and dry nasal mucosa.

• Provides essential moisture to dry and irritated noses.

• Supports the regeneration process of irritated nasal mucous membranes.

• Gently cleans nasal cavities; also suitable for preventive use.

IngredientsEctoin®, Sea Salt, Phosphate Buffer, Water.

Suitable forInfants, children, adolescents and adults.

Dosage Forms20 ml solution in bottle with dosage pump

More than just a saline nasal spray: Long-term moisturization and inflammation-reduction

Status (EU): Medical Device Class I

Study OverviewSonnemann et. al., 2014

• Significant improvement of a combined symptom score (nasal breathing obstruc-tion, blood deposits, crust formation, secretion’s viscosity).

• Excellent safety profile proven in two studies comprising 80 patients.

Ectoin® Mouth WashEctoin® Sicca Nasal Spray

Study Overview

• First individual studies show: Ectoin® Mouth Wash is able to reduce mucositis grade III and IV to grade I or even asymp-tomatic within 1–3 weeks of treatment.

• Comparator study against “Caphosol” is currently running.

Perfectly

suited for

Oncology

Supportive

Care

Dry

Epit

helia

Dry

Epit

helia

24 25

ClaimsCream for symptomatic treatment and relief of skin redness and itching experienced with various types of inflammatory dermatoses.

• Helps to relieve and calm irritated and damaged skin by reducing inflammatory reactions and supporting the regeneration process.

• Pro-active treatment of atopic dermatitis in the sub-acute state due to skin barrier stabilizing and protecting properties.

• Reduces dryness by increasing skin moisture content and therefore smoothens the skin.

• Soothes symptoms like itchiness and redness.

IngredientsEctoin®, Aqua, Hydrogenated Lecithin, Ceramide-3, Squalane, Olea Europaea Fruit Oil, Caprylic/Capric Triglyceride, Butyro spermum Parkii Butter, Oryza Sativa (Rice) Bran Cera, Carbomer, Xanthan Gum, Sodium Carbomer, Cardiospermum Halicacabum Flower/Leaf/Vine Extract, Glycine, Alanine, Penty-lene Glycol, Butylene Glycol, Hydroxyethylcellu-lose, Glycerine, Hydroxyphenyl Propamidobenzoic Acid.

Suitable forInfants, children, adolescents and adults.

Dosage FormsAirless Dispenser (30 ml, 50 ml), Aluminum Tube (30 ml, 50 ml), Sachets (2 g, 3 g, 5 g)

Status (EU): Medical Device Class IIa

Study OverviewMarini et. al., 2013; Heinrich et. al., 2007; Bünger and Driller, 2004

• Strong scientific background: More than 15 studies with diverse Ectoin®-contain-ing creams including >900 patients prove outstanding efficacy and safety of Ectoin®- containing creams.

• Tested against Atopiclair® and hydrocorti-sone-containing cream.

• Effective reduction of itching, erythema and irritation.

ClaimsEar spray for treatment of symptoms caused by non-infectious inflammation of the outer ear, for prevention of otitis externa and earwax plugs, and for eased clearing of the outer ear canal.

• Alleviates pruritus in the outer ear canal caused by allergy or inflammatory dermatoses.

• Soothes dry skin inside the ear canal.

• Reduces inflammation and supports the regen-eration process in non-infectious otitis externa.

• Helps to reduce the incidence of otitis externa, if used regularly.

• Helps against formation of earwax plugs, if used regularly.

• Cleans the ear canal.

IngredientsEctoin®, Sea Salt, Citrate Buffer, Water.

Suitable forInfants, children, adolescents and adults.

Dosage Forms20 ml solution in bottle with dosage pump (3K)

Itch reduction, soothing, and cleaning for sensitive ears

Effective and natural treatment of inflammatory dermatoses without negative side effects

Status (EU): Medical Device Class I

Study Overview

• Tested against dexpanthenol: Ectoin® Ear Spray shows significantly better improve-ment of itching, impairment of daily life and scaly skin.

• No common side effects such as tempo-rary burning or stinging were observed with the Ectoin® Ear Spray.

Ectoin® Dermatitis Cream 7 %Ectoin® Ear Spray

Also

suitable for

treatment of

allergic

symptoms

Also

suitable for

Oncology

Supportive

Care

Derm

atol

ogy

Dry

Epit

helia

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ClaimsCream for treatment and prevention of psoriasis and dermatitis symptoms.

• Supports the natural elimination of dead cells from the skin surface which is a symptom of psoriasis.

• Reduces scaling, itching, redness, roughness and hardening of the skin.

• Helps to normalize the skin cell production and maturation time of the skin.

• Stabilizes the skin barrier.

• Moisturizes the skin and prevents from further dehydration.

IngredientsEctoin®, Aqua, Cetearyl Alcohol, Urea, Cetearyl Isononano ate, Glycerin, Simmondsia Chinensis Seed Oil, Hydrogenated Polydecene, Pentylene Glycol, Hydroxyethyl Urea, Panthenol, Cetearyl Glucoside, Lecithin, Allantoin, Xanthan Gum, Ethyl hexylglycerin, Sodium Lactate, Sodium Cetearyl Sulfate.

Suitable forInfants, children, adolescents and adults.

Dosage FormsAluminum Tube (30 ml, 50 ml)

Status (EU): Medical Device Class IIa

Study OverviewVestweber, 2009

• Post-marketing surveillance study proves: Great improvement of scaliness, dryness and pruritus!

Supports elimination of plaque, reduces itching, scaling and redness

ClaimsCream for topical use on dry, irritated and sensitive skin associated with various types of dermatoses.

• Can be used between exacerbations to stabilize the skin barrier and protect the skin against external stress factors.

• Supports the regeneration process.

• Soothes dry, rough and sensitive skin.

• Provides moisture and protects against dehydration.

IngredientsAqua, Ectoin®, Hydrogenated Olive Oil, Ethylhexyl Stearate, Pentylene Glycol, Simmondsia Chinensis Seed Oil, Sorbitol, Cete aryl Alcohol, Polyglyceryl-2 Sesquiisostearate, Hexyldecanol, Hexyldecyl Lau-rate, Ethylhexylglycerin, Hydrogenated Vegetable Glycerides, Sodium Cocoyl Glutamate, Sodium Carbo-mer, Toco pheryl Acetate, Prunus Amygdalus Dulcis Oil, Citrus Tangerina Peel Oil, Hydrogenated Vegetable Oil, Tocopherol, Hydrogenated Palm Glycerides Citrate.

Suitable forInfants, children, adolescents and adults.

Dosage FormsAirless Dispenser (30 ml, 50 ml), Aluminum Tube (30 ml, 50 ml), Sachets (2 g, 3 g, 5 g)

More than just basis therapy of dermatitis

Status (EU): Medical Device Class IIa

Study OverviewMarini et. al., 2013; Heinrich et. al., 2007; Bünger and Driller, 2004

• Strong scientific background: More than 15 studies with diverse Ectoin®-con-taining creams including >900 patients prove outstanding efficacy and safety of Ectoin®-containing creams.

Ectoin® Psoriasis and Dermatitis CreamEctoin® Dermatitis Cream 3.5 %

Derm

atol

ogy

Derm

atol

ogy

28 29

ClaimsScalp Tonic for the treatment of itchy and dry scalp.

• Soothes itchiness.

• Strengthens the skin-barrier function which results in e. g. a reduced pollen allergen pene-tration into hair follicles.

• Helps to protect hair follicles from aging which is a cause for reduced hair thickness, hair density and greying.

• Reduces inflammatory reactions of the scalp.

• Supports the regeneration process of irritated scalp.

• Reduces symptoms like dryness of the scalp.

• Leaves the hair clean, is neither greasy nor heavy.

IngredientsEctoin®, Sea Salt, Water.

Suitable forInfants, children, adolescents and adults.

Dosage FormsSingle-Doses: ampoules with 2.5 mL solution (preservative-free), Multi-Doses: PET bottle with 100 mL solution (additional ingredients: Phenoxyethanol and Limonene as preservatives)

Effective itch and dandruff reduction for irritated scalp

Status (EU): Medical Device Class I

Study Overview

• Observational study shows significant improvement of dryness, redness, dandruff, and irritation after only two weeks of treatment.

bitop offers various white label cosmetic products based on Ectoin®, 28Extremoin® and Glycoin® natural.

These products have been developed to be compatible with each other as a medicinal skin care series or as a useful supplement to our medical device products.

They are formulated with carefully selected high qual-ity ingredients, matching the needs of different skin condi tions and are suitable for very sensitive skin types. All products are free from parabens or other artificial preservatives, silicones, PEGs, mineral oils, paraffins, perfumes or dyes. We constantly expand our product line with new, innovative formulations to serve our customers’ needs.

Ectoin® Scalp Tonic

Medicinal Skin Care based on extremolytes

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Ectoin® already proved its efficacy successfully in various medical devices for human use.

Now, bitop also strives to enter the ani-mal health market with three carefully selected products to treat epithelial dis-orders in dogs, cats, rodents and horses.

With “Ectoin® Vet Cream”, “Ectoin® Vet Eye drops” and “Ectoin® Vet Ear spray” bitop offers innovative solutions to soothe animal skin eczema (e. g. due to extensive lick-ing, food allergies or allergies to blackflies), irritations of the eyes as well as itching and irritations of the ears.

Also within the animal health sector, bitop remains with its principles to offer products free from potentially irri-tating substances, such as cortisones, emulsifiers, pre-servatives, perfumes and dyes.

Ectoin® Vet Ear spray

Animal Health Cosmetics and Personal Care

bitop’s natural stress protection mole-cules Ectoin®, Glycoin® natural and 28Extremoin® are also available as high- quality multifunctional cosmetic active ingredients “made in Germany”.

The skin care industry strives for the manufacturing of safe products with substantiated claims. Therefore, we have put emphasis on extensive pre-clinical and clini-cal testing of our cosmetic ingredients Ectoin®, Glycoin® natural and 28Extremoin®.

With bitop’s cosmetic actives you are able to offer pro-ducts with claims that truly deliver what they promise. Our active ingredients are easy to formulate, approved by EcoCert, COSMOS, Natrue and suitable for all skin types – even the most sensitive ones.

For further information about our innovative cosmetic actives, please contact us at [email protected]

Nature’s self-defense strategy for global skin protection and repair

Revitalizing anti-aging power by the model of nature

Comprehensive pollution protection beyond PM

Ectoin® Vet Cream

Ectoin® Vet Eye drops

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