inspire taster day brochure 2016-2017 - cardiff...

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INSPIRE

Taster Day Brochure

2016-2017

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INSPIRE is a scheme supported by the Academy of Medical Sciences and the Wellcome Trust aimed at getting medical, dental and veterinary students involved in academic research. The Universities of Bristol, Cardiff, Exeter and Plymouth are proud to have been awarded grants from this body to fund research Taster Days within prestigious research groups at the Universities. The relationships developed during these Taster Days will ideally lead to a funded INSPIRE vacation studentship (to be advertised later in the term) - and perhaps much more. How to apply This brochure contains details of the Taster Days being offered during 2016. Travel bursaries will be available to students wishing to travel to a Taster Day in a different university to their own. To apply for a 2016 Taster Day, please apply online via this link –

https://goo.gl/forms/6pVfKJcZ4FDEy4VB2 The closing date for applications is November 8th 2016 at 5pm You will be notified if you application for a taster day was successful by the 14th November 2016. We wish you the best of luck with your application and all future research endeavours.

https://goo.gl/forms/6pVfKJcZ4FDEy4VB2

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The INSPIRE Scheme; a student’s FAQs and guide. 1. What’s the INSPIRE Scheme? The INSPIRE scheme is a programme run by the Academy of Medical Sciences, and supported by the Wellcome Trust, that aims to encourage and promote medical, dental and veterinary students to learn about and get involved in research at their own schools and elsewhere, both in the UK and abroad. http://www.acmedsci.ac.uk/careers/mentoring-and-careers/INSPIRE/ The current programme will run for the next two years and is organised and co-ordinated between Cardiff, Bristol, Exeter and Plymouth schools to give students as much choice as possible for research placements and summer project opportunities. The timetable and deadlines for the scheme are at the bottom of the page. 2. How do I get involved? The major parts of the scheme are research ‘Taster days’ and summer project bursaries for students, but there are other events and programmes, such as showcase days, research conferences, a new student-led e-magazine and an intercalators’ conference. Check out your medical school’s INSPIRE website for details of events. 3. What are Taster Days? These are single day visits to a research provider’s lab or group to see research first-hand. The research taster days are advertised in October in a research booklet, students apply and then visit the labs for a day in November or December. Applications are made through a web-based system and you can apply and do more than one Taster day if you wish. Once allocated, both you and the provider will be contacted. You should then make direct contact with the provider to get more information and any background reading or arrangements for the day. As with any professional placement, if you cannot make the day, you MUST notify your provider. Student ‘no-shows’ discourage research providers from getting involved in future years! 5. What happens at the Taster day? These days are an opportunity for you to get to have find out about the research of the person you are visiting, also to consider whether you would like to apply for a summer project. Do some reading before you go and talk about the research with your provider and possible ideas and projects that would be suitable for a summer studentship. Ask them about the context of their research and why they do it! 6. What if I then want to apply for a summer studentship? Keep in contact with your provider and discuss what would make a good and do-able project within the 4-6 weeks of the project. The research proposal should be written by you; you will be sent the application forms. Bursaries are available from all 4 schools (£1000 for the successful students.) You do not have to apply for a project in the same place you have done your taster. See the deadlines below; no late applications will be accepted and the proposals are judged by a student/academic panel. After you finish your project you will be asked to write a short report; maybe even present your results at the research conference/showcase.

http://www.acmedsci.ac.uk/careers/mentoring-and-careers/inspire/

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7. Can I apply elsewhere for funding? Yes and it makes good sense to apply to more than one place. See the attached list of potential funders, but do note they will have different deadlines and conditions for their schemes.

Research Taster Booklet Released October 31st 2016

Closing Date for Applications November 8th 2016

Students Notified of Taster Day

Allocations

November 14th 2016

Taster Day Dates November 30th, December 7th and 14th

2016

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University of Bristol Taster Days MEDICAL SCIENCE-FOCUSSED RESEARCH TASTERS 1)

Research Group Name

Bacterial Infection Lab

Contact Dr Darryl Hill

Location Biomedical Sciences Building, University of Bristol

Area of Research

Bacterial infections of the respiratory tract which lead to localised or disseminated disease such as meningitis are a considerable health and financial burden globally. Our laboratory based research focuses on understanding the interplay between bacteria (mainly colonisers of the respiratory tract) and their human host during colonisation and progression of disease. By understanding key mechanisms used by bacteria to interact with human cells and tissues therapeutic targets can be identified.

Number of students and dates available

2 students on either 30th Nov or 1st Dec

2)

Research Group Name

Biomaterials Engineering Group (bioMEG)

Contact Prof Bo Su

Location Bristol Dental Hospital, University of Bristol

Area of Research

The lab focuses on studying the neural mechanisms that control urinary Lab based research in two areas: 1. Cell-instructive surfaces for smart implants – use of

nanotopographical cues to modulate cells and bacteria

Bio-inspired and biomimetic materials – engineering approach to fabricate hierarchically structured materials to mimic bone, tooth and cartilage


1 student on 30th Nov, 7th Dec or 14th Dec

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3)

Research Group Name

Brain Bladder Interactions

Contact Dr Thelma Lovick

Location School of Physiology, Pharmacology and Neuroscience, Biomedical Sciences Building, University of Bristol

Area of Research

The lab focuses on studying the neural mechanisms that control urinary continence and the identification of new approaches to manage urge urinary incontinence. We use animal models, principally rats. Techniques include urodynamic measurements in rats under anaesthesia; recording activity of neurones within the micturition control circuits in the brain to understand their functioning; measurement of 24h voiding patterns in conscious rats and the effect of selective neurotoxic lesioning of specific cell groups in the brain; chronic implantation of devices to measure bladder pressure and stimulate nerves; use of high frequency pelvic nerve stimulation to inhibit urinary voiding.


2 students on 14th Dec

4)

Research Group Name

Bristol Renal (Includes: Prof Richard Coward; Prof Moin Saleem; Dr Gavin Welsh, Dr Seb Oltean; Dr Simon Satchell; Dr Becky Foster; Dr Natalie Finch)

Contact Prof Richard Coward

Location School of Clinical Sciences, Dorothy Hodgkin Building, University of Bristol

Area of Research

Lab based research. Molecular biology underpinning kidney disease including diabetic nephropathy, nephrotic syndrome, surgical kidney issues.


Up to 10 students on the 7th of Dec

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5)

Research Group Name

Cell Biology Lab

Contact Professor David Stephens

Location School of Biochemistry, Biomedical Sciences Building, University of Bristol

Area of Research

Lab based molecular cell biology research. We have two major inter-related projects: 1. Molecular mechanisms of the dynein-2 cytoplasmic motor in cilia biology. 2. Secretion of procollagen by the COPII vesicle trafficking system. The lab itself is using high-resolution light microscopy of living cells, notably live cell imaging, in 3D over time, to examine the organization and function of the mammalian secretory pathway both in healthy cells as well as in disease states. In this regard our work focusses on collagen secretion and the formation and function of primary cilia. For further details see: www.stephenslab.wordpress.com


Up to 2 students on 14th Dec

6)

Research Group Name

Cognitive Neuroscience – Synapse to Society (Including research from the labs of Dr Jones, Prof Mellor, Dr Ashby and Dr Pickering)

Contact Dr Tony Pickering


Area of Research

Featuring research groups using a wide range of approaches from synaptic and cellular to systems and behavioural neuroscience. As applied to investigate mechanisms of learning and memory, cognition, pain perception, neuromodulation and neural development working from the bench-side of the translational spectrum. (For more details see http://www.bristol.ac.uk/phys-pharm/)


Up to 12 students on 30th Nov

http://www.stephenslab.wordpress.com/

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7)

Research Group Name

Clinical Neuroscience @ Southmead (Includes: Dr Liz Coulthard; Dr Claire Rice; Dr Ali Bieneman)

Contact Dr Ali Bieneman

Location School of Clinical Sciences, Learning and Research Centre, Southmead Hospital, University of Bristol

Area of Research

Clinical neuroscience is based at Southmead Hospital where there is a flourishing research community spanning laboratory work in the Learning and Research building and more clinical research in the Bristol BRAIN centre. Laboratory science mainly focusses on neural mechanisms and therapeutic advances in Parkinson's disease, multiple sclerosis, brain tumours and dementia. Working closely with the laboratory scientists are the clinical academics who run trials of novel therapeutics in people affected by neurological disease.


A group of up to 12 students. 7th Dec 1-2pm

8)

Research Group Name

CRIC Bristol

Contact Dr Jade Thai

Location CRICBristol, 60 St Michael's Hill, Bristol

Area of Research

Clinical Applications of Neuroimaging Functional brain mapping studies of healthy volunteers and clinical populations including Chronic Fatigue Syndrome and Multiple Sclerosis to investigate the impact of fatigue on brain function.


2 students. Date to be arrange with Dr Thai

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9)

Research Group Name

Cystic Fibrosis Group

Contact Dr David Sheppard

Location School of Physiology and Pharmacology, Biomedical Sciences Building, University of Bristol

Area of Research

Lab based research. This group investigates the cystic fibrosis transmembrane conductance regulator (CFTR). Mutations in CFTR cause the life-shortening genetic disease cystic fibrosis (CF). Lab-based research methods are used to explore CFTR structure and function, learn how CF mutations cause CFTR malfunction and investigate the mechanism of action of small-molecules that modulate CFTR activity. These small-molecules include drugs that target the root cause of CF by restoring CFTR expression and function and chemicals that inhibit CFTR function, which might be used to develop new therapies for secretory diarrhoea and autosomal dominant polycystic kidney disease.


2 students. Date to be arranged with Dr Sheppard

10)

Research Group Name

Diabetes and Metabolism

Contact Dr Kathleen Gillespie


Area of Research

Combination of laboratory and population-based studies focused on prediction and prevention of type 1 diabetes. This involves detection of genetic markers and islet autoantibodies that predict future type 1 diabetes.


2 students on 30th Nov, 7th Dec, 8th Dec or 14th Dec

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11)

Research Group Name

Fly Lab

Contact Dr James Hodge

Location School of Physiology and Pharmacology, Biomedical Sciences Building, University of Bristol

Area of Research

Lab based research. We are interested in the molecular mechanisms and neural circuit changes that underlie behaviour. We are taking advantage of the fantastic genetic toolbox available in Drosophila to tackle this problem. We are studying age related memory decline and sleep disruption in Alzheimer and Parkinson’s models including the effect on neurodegeneration and movement. For more details see: http://www.bristol.ac.uk/phys-pharm/people/james-j-hodge/index.html


2 students on 30th Nov

12)

Research Group Name

Glucocorticoid Lab

Contact Dr Becky Conway-Campbell


Area of Research

Lab based research. Investigating the molecular, physiological and behavioural effects determined by normal and dysregulated glucocorticoid exposure. Glucocorticoids (GCs) regulate diverse physiological processes including metabolism and immune function, as well as stress responsiveness, cognitive processing and behavioural adaptation. Furthermore, chronic stress, and disease states such as arthritis, depression and sleep apnea are associated with significant alterations in the circadian GC profiles of patients. We use a range of techniques including cell culture, molecular techniques, histochemistry, imaging, in vivo models and behavioural testing,



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13)

Research Group Name

IGFs and Metabolic Endocrinology Group (IMEG)

Contact Dr Claire Perks


Area of Research

Laboratory based research. IMEG is focused on how nutrition and metabolism contribute to the development of major chronic disorders, such as cancer with a specific interest in the role of insulin-like growth factors. We particularly focus on breast and prostate cancer.



14)

Research Group Name

Learning and Memory (Including; Prof Graham Collingridge; Dr Zuner Bortolotto)

Contact Dr Zuner Bortolotto

Location School of Physiology, Pharmacology and Neuroscience, Dorothy Hodgkin Building, University of Bristol

Area of Research

Our research is focused on basic mechanisms underlying learning, memory and neurological disorders. We also work on development of new pharmacological tools to explore synaptic plasticity in health and disease.


2 students. Date to be arranged with Dr Bortolotto.

15)

Research Group Name

Neuroendocrinology Research Group (Prof Stafford Lightman’s group)

Contact Dr Francesca Spiga


Area of Research

Lab based research projects investigating the origin and regulation of glucocorticoids secretion in physiological and pathological conditions.


2 students. Date to be arranged with Dr Spiga (late Nov to early Dec)

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16)

Research Group Name

Ophthalmology Research Group

Contact Dr Colin Chu

Location School of Clinical Sciences, Biomedical Sciences Building, University of Bristol

Area of Research

We perform predominantly laboratory research to understand eye disease and develop new treatments. We work on both human tissues and experimental animal models of eye diseases. Across the group we work on gene therapy, the immune system and neovascularisation. Students will be able experience a range of laboratory techniques on the day including PCR, tissue culture, immunofluorescent microscopy and ocular dissection.



17)

Research Group Name

Paediatric Infection and Immunity

Contact Prof Adam Finn and Dr Begonia Morales-Aza

Location School of Cellular and Molecular Medicine / School of Clinical Sciences, Biomedical Sciences Building, University of Bristol

Area of Research

The Bristol Children's Vaccine Centre (BCVC) is a group of doctors, nurses and scientists working together to develop new, better ways to prevent and treat infectious diseases. The main focus of the BCVC is on translational research related to mucosal vaccine development and specifically the mucosal immune response to pneumococcus. We conduct clinical trials to evaluate novel drugs and vaccines, from small early-phase safety studies through to larger efficacy trials. We also carry out other clinical research studies to find out more about the naturally occurring carriage of bacteria (e.g. Streptococcus pneumoniae and Neisseria meningitidis) and/or viruses (such as influenza) in healthy individuals, and how this changes in illness. This work can take the shape of large epidemiology-type studies or smaller lab-based research projects that use human tissue samples (blood, adenoids, nasal swabs, throat swabs and saliva).


2 students on each day: 30th Nov; 7th Dec; 14th Dec

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18)

Research Group Name

Regenerative Medicine Laboratories (Including Prof James Uney; Dr Liang-Fong Wong; Dr Oscar Cordero Llana)

Contact Dr Oscar Cordero Llana

Location School of Clinical Sciences / School of Cellular and Molecular Medicine, Biomedical Sciences Building, University of Bristol

Area of Research

Lab based / Clinical The Bristol Regenerative Medicine laboratory (BRML) is a multidisciplinary research laboratory, encompassing world-class experts in biomaterials, gene therapy and tissue regeneration. We study a broad range of chronic diseases, such Parkinson’s disease, Huntington’s Disease, traumatic spinal cord injury and childhood leukaemia. The methodologies used in our laboratory include stem cells (iPSCs, ESCs, MSCs, NSCs), molecular biology, tissue engineering, animal models, bioinformatics, etc.


4-6 students on 30th Nov

19)

Research Group Name

Research into Safety & Quality Group (RiSQ) Group (Academic Centre of Women’s Health) (Including Dr Christy Burden; Prof Tim Draycott; Mr Dimitrios Siassakos)

Contact Dr Christy Burden

Location School of Social and Community Medicine, The Chilterns, Southmead Hospital, University of Bristol

Area of Research

Professor Tim Draycott has particular expertise in outcome based research, multi-professional training for Obstetric Emergencies, team working and dashboards in maternity care including work in Global Heath. Mr Dimitrios Siassakos is a member of several international academic initiatives to improve the management of stillbirth and neonatal death through robust research. Current work includes commissioned projects for the Lancet stillbirth series, and research projects to inform Department of Health task groups, national guidelines, and NIHR-funded research. Other areas of research include bariatric, maternal and reproductive medicine. The research study designs undertaken vary from clinical trials to mixed methodology and qualitative studies.


1 student on 29th Nov; 1 student on 30th Nov

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DENTAL SCIENCE-FOCUSSED RESEARCH TASTERS 20)

Research Group Name

Oral Nanoscience Group

Contact Dr Michele Barbour

Location Bristol Dental Hospital, University of Bristol

Area of Research

The Oral Nanoscience group is interested in the exploitation of nanoscience and nanotechnology in dental materials and oral care products. We are particularly interested in antimicrobial technologies, and have recently developed a novel nanoparticulate form of chlorhexidine. We are currently engaged in investigation of the properties of this new material and its application in materials such as glass ionomers, bonding materials and toothpastes. We are laboratory-based and very interdisciplinary; current and recent group members have first degrees which include chemistry, biomaterials science, biomedical science, engineering, physics and microbiology as well, of course, as dentistry. You can expect to spend your time in the lab working with our chlorhexidine nanoparticles and investigating how these might be applied in the oral environment.


2 students on 30th Nov, 7th Dec or 14th Dec

VETERINARY SCIENCE-FOCUSSED RESEARCH TASTERS 21)

Research Group Name

AMR Force (Includes: Dr Kristen Reyher; Prof David Main; Prof David Barrett)

Contact Dr Kristen Reyher

Location School of Veterinary Sciences, Dolberry Building, Langford, University of Bristol

Area of Research

We are a group of veterinarians and researchers interested in decreasing antimicrobial use while improving animal health through a plurality of approaches. We have strong links and collaborations with social scientists along with a track record of influencing behaviour change in animal health and welfare on farms. We currently are involved at a high level in influencing the use of medicines on farms in the UK and have for the past five years been conducting medicines audits within our practice and reducing the use of higher level medicines on our farms. More info here: http://www.bristol.ac.uk/vetscience/research/infection-immunity/main/


No limit – happy for them to attend our monthly update meetings on 6th Oct, 3-5 pm or 9th Nov, 3-5 pm

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22)

Research Group Name

Animal Welfare and Behaviour

Contact Prof Christine Nicol and Dr Anna Davies (send email to both)

Location School of Veterinary Sciences, Langford, University of Bristol

Area of Research

Experimental studies to validate welfare indicators in animals. Current work involves training individual laying hens to perform cognitive tasks. We then assess biases in their cognition which may arise due to changes in their welfare state. Hands-on, animal house.


1 or 2 students on 30th Nov

Research Group Name

Animal Welfare and Behaviour

Contact Dr Jo Edgar

Location School of Veterinary Sciences, Langford, University of Bristol

Area of Research

Research project on the use of natural maternal behaviour to improve welfare in farmed chickens. The project may involve work with chickens here at Langford, or on-farm study, depending on the chosen days. It will involve behavioural observations and tests on chicks and pullets, to assess their welfare.


1 student – day is dependent on when next study begins but can be discussed nearer the time.

23)

Research Group Name

Bristol Cats Study

Contact Dr Jane Murray

Location School of Veterinary Sciences, Dolberry Building, Langford

Area of Research

The 'Bristol Cats' study is a longitudinal study of a cohort of cats that were enrolled as kittens. Approximately 2200 cats were registered with the study (2010-2013) and 1500 owners of 1800 cats (aged 3-6.5 years) are still actively involved in the study. Data are collected via owner-completed questionnaires and from vets of study cats. Hair, faecal and cheek cell swab samples are also collected from some cats. Based on the Bristol Cats dataset, epidemiological techniques are used to identify factors associated with an increased/decreased odds of a range of health and behavioural outcomes.



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24)

Research Group Name

Equine Pain

Contact Ms Veronica Roberts

Location School of Veterinary Sciences, Langford Equine Hospital, University of Bristol

Area of Research

Trigeminal-mediated headshaking is a neuropathic facial pain syndrome in horses, of unknown cause. There are no good, safe treatments and many horses are euthanased. We are developing a new, minimally invasive treatment, with encouraging results. Students would see investigation of clinical cases and the use of the new treatment.


2 students per visit. Date to be arranged with Veronica Roberts (depends on cases) after Spring 2017.

25)

Research Group Name

Feline Infectious Diseases

Contact Dr Séverine Tasker

Location School of Veterinary Sciences (SVS), Churchill Building, Langford, University of Bristol; School of Cellular and Molecular Medicine (CMM), Biomedical Sciences Building, University of Bristol

Area of Research

This group is involved in the laboratory investigation of feline infectious agents. A primary interest is haemotropic mycoplasmas (haemoplasmas), which are bacterial agents that can induce haemolytic anaemia in a range of host species. Most of our studies centre on the feline haemoplasmas but we have carried out research on other haemoplasma species including canine, rodent and human species. We also work on feline coronavirus (FCoV) infection, a virus that can cause feline infectious peritonitis (FIP). Current research involves the development of reliable diagnostic tests for FIP, deriving genome sequences of field coronavirus isolates and identification of feline coronavirus host receptors.


2 students on 30th Nov (CMM with Sam Saunders, Veterinary PhD student) 2 students on 7th Dec (SVS with Serina Filler, Veterinary PhD student)

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26)

Research Group Name

Mucosal Immunology Lab

Contact Prof Mick Bailey

Location School of Veterinary Sciences, Churchill Building, Langford, University of Bristol

Area of Research

We carry out primarily lab-based studies on the impact of early life, particularly colonisation with commensal bacteria, on development of the mucosal immune system. We use pigs primarily, because they are agricultural species as well as good models for humans. In addition, we work on swine influenza and on pig-as-biomedical-model, particularly transplantation.


2 students, ideally together, on Nov 30th or Dec 14th

27)

Research Group Name

Sustainable Livestock Systems and Food Security

Contact Prof Michael Lee

Location Rothamsted Research, North Wyke, Okehampton, Devon, EX20 2SB

Area of Research

Sustainability of grazing livestock systems. The use of the BBSRC North Wyke Farm Platform National Capability (www.rothamstedresearch/farmplatform) to measure the true impact (emissions, animal health) and value (product quality, economic, social) of different ruminant livestock production systems.


A mini bus full of students between 5th – 8th Dec

28)

Research Group Name

T-cell Immunology Lab

Contact Prof Linda Wooldridge


Area of Research

Role of T-cells in diseases such as autoimmunity, transplant rejection and leukaemia. In addition, a strong interest in the development of cancer immunotherapy.


2 students. Date to be arranged with Prof Wooldridge

http://www.google.co.uk/url?sa=i&rct=j&q=&esrc=s&source=images&cd=&cad=rja&uact=8&ved=0ahUKEwjv5sjO0fDOAhWTDRoKHcrdCxUQjRwIBw&url=http%3A%2F%2Fwww.wageningenacademic.com%2Fconferences%2Feaap&psig=AFQjCNFgW7M3bl108pnlY_N24wmgjHVqOg&ust=1472904019714468

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29)

Research Group Name

Veterinary Parasitology and Ecology

Contact Dr Eric Morgan

Location School of Veterinary Sciences, Life Sciences Building, University of Bristol

Area of Research

We conduct computer, lab and field based research on populations of parasites in domestic and wild animals, and their diagnosis and control. Our group of around 20 researchers and postgraduate students currently runs lab projects on roundworms, flatworms, ticks, mites and flies that parasitise a wide range of animal hosts.


Up to 3 students on 7th or 14th Dec or by arrangement.

Cardiff University Taster Days

MEDICAL SCIENCE-FOCUSSED RESEARCH TASTERS

30) Research Group Name

Diabetes/metabolism

Contact Prof Colin Dayan

Location Infection and Immunity, Cardiff University, C2 Link, Heath Park, UHW, CF14 4XN

Area of Research

Protecting beta cells from immune destruction in type 1 diabetes - laboratory and clinical studies. To introduce students into the different project in the group - developing new ways to induce immune tolerance with a "diabetes vaccine", how we develop early phase clinical trials and studies on large cohorts of children with type 1 diabetes.


4 students on 30th Nov or 14th Dec 2016

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31)

Research Group Name

Immunology

Contact Prof Paul Morgan

Location Infection and Immunity, Cardiff University

Area of Research

Biomarkers and their measurement. See and learn how biologically important molecules relevant to disease are measured and how these measurements help predict disease.


4 students on 14th Dec 2016

32)

Research Group Name

Psychiatry

Contact Prof George Kirov

Location Psychiatry, Cardiff University

Area of Research

Identifying new copy number variations in schizophrenia. The students will observe our work on the analysis of genetic data from several thousand cases and controls. The subjects have already been genotyped, so the work will be done in offices, in front of computers. The students will be able to familiarise themselves with some of the pitfalls and biases that can occur in research settings of this type, the statistical methods we use and the process of writing papers.


1 student on 30th Nov, 7th Dec or 14th Dec 2016

33)

Research Group Name

Viral Immunology

Contact Dr Eddie Wang

Location Infection & Immunity, Cardiff University

Area of Research

Modulation of host immunity by human cytomegalovirus. Introduce human cytomegalovirus as a pathogen and its use in research as a paradigm for immune evasion, which has aided our understanding of the host immune system. Demonstrate assays used in our research.



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34)

Research Group Name

Cancer biology

Contact Dr Tracey Martin

Location C&G, Cardiff University

Area of Research

Tight junction as regulators of Cancer metastasis. To see how Cell function assays, Molecular biology and protein analysis can investigate Cancer metastasis.


4 students on 30th Nov 2016

35)

Research Group Name

Diabetes

Contact Prof F. Susan Wong

Location IMEM, Cardiff University

Area of Research

Can autoantibody secreting cells be detected in Diabetes? Introduction to some laboratory techniques used in investigation of autoimmune diabetes.


2 students on 30th Nov, 7th Dec or 14th Dec 2016

36)

Research Group Name

Diabetes



Area of Research

Genetic analysis of DNA by PCR. Introduction to some laboratory techniques used in investigation of autoimmune diabetes.



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37)

Research Group Name

Diabetes



Area of Research

Introduction to some laboratory techniques used in investigation of autoimmune diabetes.



38)

Research Group Name

PET/CT imaging / Radiochemistry

Contact Dr Stephen Paisey

Location PETIC, Cardiff University

Area of Research

Behind the scenes introduction to the facilities and research at PETIC (the Positron Emission Tomography Imaging Centre. PETIC runs the national clinical diagnostic service for PET/CT in Wales and has an active many research projects in PET tracer development. We will provide a behind the scenes introduction to the facilities required for PET imaging (clinical and pre-clinical imaging).



39)

Research Group Name

Infection and Immunity

Contact Prof Tim Walsh

Location Infection and Immunity, Cardiff University

Area of Research

Superbugs: what they are and what they do!



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40)

Research Group Name

Neuroinflammatory research group

Contact Neil Robertson

Location UHW, Cardiff University

Area of Research

Our research integrates NHS service with the epidemiology of multiple sclerosis and related diseases employing IT systems with clinical and research utility linked to a biobank. This enables recruitment to clinical trials, effective patient counselling through improved understanding of outcomes and offers research engagement to all patients. We explore laboratory and clinical biomarkers of disease progression/outcome with long term aims of developing more targeted patient-specific interventions.



41)

Research Group Name

Bone Research Lab

Contact Dr Bronwen Evans

Location UHW, Cardiff University

Area of Research

How does mechanical loading of bone prevent osteoporosis? - Lab based Our work investigates the cellular and molecular mechanisms involved in the responses of bone and other musculoskeletal tissues to mechanical loading. Recently we have been developing new 3D models to enable the study of osteocytes (mechanoresponsive cell in bone) in a meaningful environment and in such a way that we can apply physiological mechanical load. The studies aim to develop new strategies for the prevention and treatment of conditions such as osteoporosis and osteoarthritis.


4 students on 7th Dec AM 2016

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University of Exeter Taster Days MEDICAL SCIENCE-FOCUSSED RESEARCH TASTERS 42)

Research Group Name

Child Mental Health

Contact Prof Tamsin Ford

Location Institute of Health Research , University of Exeter, South Cloisters, St. Luke’s Campus

Area of Research

Factors influencing childhood psychiatric disorder, mental health and well-being, including interventions. We are currently running one randomised controlled trial, a systematic review and a number of observational studies



43)

Research Group Name

Exeter HeSRU Colorectal & CAWR Surgical Group

Contact Mr Ian Daniels and Mr Neil Smart

Location Exeter HeSRU, Knox-Irvine Seminar Room, Royal Devon & Exeter Hospital. www.hesru.org

Area of Research

We have accommodated students on a number of projects from purely clinical – stoma site hernia progression, biomarkers of response to chemoRT in rectal cancer, progression of AIN to anal cancer, MRI of the perineum post-elAPE. So we focus mainly on rectal cancer, recurrent pelvic cancer and complications of surgery.



44)

Research Group Name

Exeter Orthopaedics research group

Contact Mr Andrew Toms

Location Lecture Theatre, Princess Elisabeth Orthopaedic Centre, Royal Devon & Exeter Hospital.

Area of Research

Orthopaedic surgery



http://www.hesru.org/

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45)

46)

Research Group Name

Primary Care

Contact Dr Chris Clark

Location Institute of Health Research, University of Exeter, Smeall Building, St. Luke’s Campus

Area of Research

Primary care clinical research covering topics such as- Significance and implications of a difference in blood pressures

between arms

Organisation and management of care in hypertension in primary care

Estimation and early detection of cardiovascular risk

Recognition and management of postural hypotension in primary care



47)

Research Group Name

Functional Cell Biology

Contact Prof Robert Pawlak

Location Institute of Health Research, University of Exeter, College House, St Lukes Campus

Area of Research

Molecular mechanisms of fear and anxiety


4 students dates TBC

Research Group Name

Respiratory Medicine

Contact Dr Chris Scotton and Dr Michael Gibbons

Location IBCS, University of Exeter, Medical School Building, St Lukes Campus

Area of Research

Lung disease is responsible for 20% of all deaths in the UK. Our group is trying to unravel the cell and molecular mechanisms underlying the development of lung disease, particularly lung fibrosis, with a view to identifying novel diagnostics and therapeutics, including regenerative medicine approaches. Our clinical studies are supported by close ties with the RD&E and Exeter Clinical Research Facility.



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48)

Research Group Name

REACH team.

Contact Dr Siobhan O’Dwyer

Location Centre for Research in Ageing and Cognitive Health, University of Exeter, St Lukes Campus

Area of Research

Research into Ageing and Cognitive health to include areas such as- Suicide and homicide risk in family carers

Resilience in family carers

Non-pharmacological approaches to dementia care



49)

Research Group Name

Molecular Genetics

Contact Dr Lorna Harries

Location IBCS, University of Exeter, RILD building, RD7E site

Area of Research

My group are interested in gene expression and gene regulation, particularly in how these mechanisms can influence human diseases. We are a lab-based group, engaged in basic science research to uncover the molecular causes of chronic diseases including diabetes, dementia and ageing itself. The work uses both population-level analysis, and also focused in vitro work to assess cause and effect and define mechanism. Current projects include analysis of deregulation of splicing during human ageing, functional analysis of genetic variants associated with type 2 diabetes and assessment of the effect of endocrine disrupting chemicals on gene expression or gene regulation



50)

Research Group Name

Endothelial Cell Biology and Cancer

Contact Dr Jackie Whatmore

Location Institute of Biological and Clinical Sciences, University of Exeter, St Lukes Campus

Area of Research

Endothelial Cell Biology and Cancer


4 students on 30th Nov or 7th Dec 2016

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51)

Research Group Name

Cell Biology

Contact Dr David Allard

Location IBCS, University of Exeter, Medical School Building, St Lukes Campus

Area of Research

Tumour microenvironment


4 students on 7th Dec or 14th Dec 2016

52)

Research Group Name

Health Services and Policy Research Group

Contact Dr Jon Evans

Location Institute of Health Research, University of Exeter, Smeall Building, St Lukes Campus

Area of Research

The research focuses on the application of Patient Reported Outcome Measures for the development of Patient-led treatment pathways in upper limb tendinopathy


4 students on 30th November and 7th Dec

27

Plymouth University Taster Days MEDICAL SCIENCE-FOCUSSED RESEARCH TASTERS 53)

Research Group Name

Derriford Hospital Summer spine research school

Contact Himanshu Shamra, Consultant Orthopaedic Spinal Surgeon

Location Level 4, Moorgate ward, Derriford Hospital

Area of Research

The spine research school would provide a plenty of opportunities to do a variety of clinical studies relating all the aspects of spinal disorders and Spinal Surgery. The specific topics of clinical interest include the management of cervical degenerative spinal disease, the management of lumbar degenerative spinal disease (disc prolapse, spinal stenosis, spondylolisthesis, adult deformity), patient reported outcomes, spinal tumours, spinal infections and spinal trauma with and without spinal cord injuries. Studies related to the allied branches to spinal surgery could also be undertaken as per students’ interests. The research student is expected to do a detail literature search on the chosen topic, collect & analyse relevant data, prepare an abstract for scientific presentation, write-up a full paper and submit it for anticipated publication in a peer reviewed journal by the end of SSU period.


7th December 12-2pm 2-3 students 14th December 12-2pm 2-3 students

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54)

Research Group Name

Basic pathology of disorders of human nervous system

Contact Dr Aditya Shivane

Location Level 4, Derriford Hospital, Plymouth

Area of Research

Neuropathology is a highly specialized branch of histopathology which deals with the gross and microscopic analysis of tissues of the nervous system. Neuropathologists therefore aid clinicians in arriving at a diagnosis. We are a small team of two neuropathologists and four biomedical scientists incorporated in a larger histopathology department. We collaborate with the neurosciences team in the Peninsula School of Medicine and Dentistry on various research projects (eg. tumours of the CNS, Parkinson disease). The aim of this taster session is to give you an insight into the basics of neuropathology.


2 students on 7th December.

55)

Research Group Name

Person Centered Coordinated Care for frail elderly and multimorbidity

Contact Helen Lloyd/Richard Byng

Location Plymouth Science Park, Derriford, Plymouth

Area of Research

This programme of work focuses on how new models of care and clinical encounters for individuals with frailty or multiple long term conditions can be developed and evaluated. We are developing ways of sharing decisions and delivering care with patients who have complex social, emotional and medical needs. The research is community and office based using quantitative (epidemiological, data base, questionnaire, trial) and qualitative (interviews, observation) methods, working with services across the south west.


4 students on one day

29

56)

Research Group Name

Hepatology Research Group

Contact Dr Dan Felmlee

Location Peninsula University Peninsula School of Medicine and Dentistry

Area of Research

Hepatitis C virus (HCV) infects 3% of the global population and transmitted through contaminated blood products. The majority of those infected carry a chronic infection that leads to liver disease and hepatic cancer. Our group previously studied of a cohort of individuals that were exposed to HCV, but amazingly cleared the virus without showing antibody evidence of exposure. Genetic studies of this population reveal unique alleles in a region of anti-viral genes that may enable these individuals to escape infection. We will pursue this investigation by identifying other differences in sequence and testing our findings functionally in cell culture models.



57)

Research Group Name

Primary Care – Behaviour Change

Contact Prof Adrian Taylor

Location Plymouth Science Park, Plymouth University, Derriford, Plymouth

Area of Research

We currently lead three multisite randomized controlled trials funded by the NIHR involving the design and evaluation of a complex intervention to support health behaviour change. Each involves Public and Patient Involvement, translation of psychological theory into practice, a logic model, and detailed process evaluation. Each study involves the Peninsula Clinical Trials Unit. Students will gain an insight into the respective challenges faced by conducting such research, including recruitment of patients in disadvantaged community settings, study retention, and taking studies from development and pilot phases into definitive trials.



30

58)

Research Group Name

The Tieu Laboratory

Contact Dr Wai-Ling Kok


Area of Research

The debilitating movement symptoms in patients with Parkinson’s disease (PD) are primarily caused by the death of dopaminergic neurons. Understanding why these neurons die or do not function properly may lead to new therapies for PD. Mitochondria, the powerhouses of the cell, are highly dynamic and they undergo frequent changes in shape, size, number and location. These dynamic processes can be controlled by mitochondrial fission and fusion. Manipulating these processes has considerable potential for treating human neurological conditions. One primary interest of this laboratory is to develop therapeutic strategy for PD by targeting mitochondrial fusion/fission.


2 students

59)

Research Group Name

Collaboration for the Advancement of Medical Education Research and Assessment (CAMERA)

Contact Dr Julian Archer and Dr Sam Regan de Bere


Area of Research

CAMERA brings together academic researchers, medical professionals, educators and policy makers interested in the improvement of healthcare through evidence-based education. We focus on assessment and its impact across the continuum of medical education from student selection to professional regulation. We have a high profile in educational, regulatory and clinical literatures. We work closely with key national institutions including the GMC and other regulators, the Health Foundation, the Department of Health and the National Institute of Health Research (NIHR). Our findings inform debate, policy and practice at local, national and international levels. Population-based research using various qualitative and quantitative methodologies


3 students

31

60)

Research Group Name

Neurobiology- Understanding tumours of the nervous system.

Contact Professor David Parkinson


Area of Research

Schwann cells are the glial cells of the peripheral nervous system and provide the myelin that allows the rapid propagation of action potentials. The loss of the tumour suppressor protein Merlin leads to the formation of schwannomas in patients. My lab studies the biology of these tumours using both primary human schwannoma cells and transgenic mouse models to understand the changes in cell signaling that underlie the uncontrolled proliferation of Schwann cells lacking Merlin. Please see Doddrell et al (2013), Brain 136: 549-63 for details of the kinds of research we do. Research type: Lab based project.


2 students on 30th November and 2 students on 7th December

61)

Research Group Name

Medical microbiology

Contact Dr Mat Upton


Area of Research

Lab based, medical microbiology and bacterial genomics My group is investigating the pathogenesis, epidemiology and genomics of uropathogenic E coli (UPEC), which are the leading cause of urinary tract infection. We are developing and commercializing rapid diagnostic assays for UPEC. We also carry out discovery of novel antibiotics. Lead compounds are being developed towards clinical use for therapy of infections caused by antibiotic resistant Gram-positive bacteria, including MRSA.



32

62)

Research Group Name

Clinical neurobiology

Contact Prof Oliver Hanemann and Dr Sara Ferluga


Area of Research

Meningiomas are slow growing tumours of the meninges. There is no treatment available after resection other than radiation-therapy; therefore it is a great medical need to find new drugs to treat these patients. We want to identify meningioma diagnostic, predictive or prognostic biomarkers. In particular, we will analyse the phosphoproteome from meningiomas with different genotype: phosphoproteins present in all samples are indicative of common upregulated pathways that could possibly be targeted. The final goal of this project is the identification of the best suitable drug, already in clinical trial or general practice, to target common up-regulated pathways in meningioma patients.



63)

Research Group Name

Translational neurobiology

Contact Prof Robert Fern


Area of Research

We are interested in injury to the developing white matter of the brain, which is selectively damaged in cases of cerebral palsy; we also study stroke injury in the brain. Projects can use electrophysiology, electron microscopy or immuno-staining to examine an aspect of cellular injury. This is a lab based project although there is potential for projects using CT data from stroke patients.



33

64)

Research Group Name

Peripheral nerve regeneration group

Contact Dr Xin-peng Dun


Area of Research

The peripheral nervous system differs from the central nervous system in that it is capable of remarkable regeneration after injury, but this astonishing regenerative capability is limited after transection injury due to the loss of the integrity of the original axonal paths necessary for highly efficient and accurate regeneration. In order to understand the molecular mechanisms contributing this regenerative failure, our group is currently using global and conditional gene knockout mouse as our research models to study the role of several transcription factors, canonical MAPK signalling pathways and axonal guidance molecules in peripheral nerve repair. Research type: Lab based project.



65)

Research Group Name

Dr. Oleg Anichtchik

Contact Dr. Oleg Anichtchik


Area of Research

We are looking at the mechanisms of protein aggregation in neurodegeneration. In particular, we examine function of beta-synuclein in in Parkinson’s disease and dementia with Lewy bodies.



34

DENTAL SCIENCE-FOCUSSED RESEARCH TASTERS 66)

Research Group Name

Dental and Oral Research Group

Contact Dr. Bing Hu

Location Peninsula Schools of Medicine & Dentistry

Area of Research

The current research topics (research lab based) of my group include:

1. The molecular mechanism in controlling epithelial stem cell fate both in development and in cancer;

2. The role of mesenchymal-epithelial interactions in organogenesis and cancer initiation.



67)

Research Group Name

Tissue Engineering

Contact Dr. Vehid Salih

Location Peninsula Schools of Medicine & Dentistry- Dental School

Area of Research

This research is totally laboratory-based and involves a variety of research methods including 2D and 3D cell culture, a variety of microscopy, basic molecular biology, ELISA, Histology, Flow Cytometry, Materials Testing and Biochemical assays. My current research combines both 2D and 3D cell culture methods to develop in vitro models and assays for diseases of the oral tissues, in particular the oral mucosa. The work also encompasses oral tumours and mimicking infection of in vitro mucosa to understand the microbial and tissue interactions. I am also interested in standardizing in vitro assays for tissue engineered scaffolds.


3 students on 30th Nov and 14th Dec

35

68)

Research Group Name


Contact Dr. Svetislav Zaric


Area of Research

Lab based and clinical research. My research interests include microbiology of periodontal diseases, host-pathogen interactions, Toll-like receptors signalling, immunopathogenesis of chronic inflammation and mechanisms involved in the resolution of inflammatory response (endotoxin tolerance). I am particularly interested in the chemical composition of Porphyromonas gingivalis LPS, with regards to its lipid-A structure and sialylation, and in consequences these changes have on the host’s immune response. Another area of my research interest are molecular and cellular mechanisms responsible for tissue injury during inflammation, identification of therapeutic targets for resolution of inflammation and oral-systemic health connection.



69)

Research Group Name


Contact Dr Louise Belfield


Area of Research

Macrophages play a vital role in the orchestration of immune responses to pathogenic stimuli. My research interests lie in how normal macrophage differentiation and function may be altered in oral diseases, particularly periodontal disease and oral cancer. Current research projects include:

- Porphyromonas gingivalis induced macrophage effector functions and their influence on osteoclast activity in periodontal disease

- Development of an in vitro, 3-D model of the oral mucosa to study oral cancer and stromal cell interactions

- Development of an in vitro, 3-D model of the oral mucosa to study host-pathogen (biofilm) interactions.

Research type: Lab based project.


2 students on 14th December

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