institute of food research ifr forward open day 2006 7 september 2006
TRANSCRIPT
Institute of Food Research
IFR FORWARDOPEN DAY 2006
7 September 2006
2
GutBiology
Nutrition,Diet & Health
MolecularMicrobiology
FoodBiophysics
IFR Science Skills Base
3
GutBiology
Understanding gut health and function
Good Guys
11
Eat for Life
5
4
GutBiology
Nutrition,Diet & Health
A volunteer’s life
How our diet influences our long-term health
Human Nutrition Unit
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Obesity Trends* Among U.S. AdultsBRFSS, 1985
No Data <10% 10%–14%
Source: Behavioral Risk Factor Surveillance System, CDC
No Data <10% 10%–14%
Obesity Trends* Among U.S. AdultsBRFSS, 1986
Source: Behavioral Risk Factor Surveillance System, CDC
No Data <10% 10%–14%
Obesity Trends* Among U.S. AdultsBRFSS, 1987
Source: Behavioral Risk Factor Surveillance System, CDC
No Data <10% 10%–14%
Obesity Trends* Among U.S. AdultsBRFSS, 1988
Source: Behavioral Risk Factor Surveillance System, CDC
No Data <10% 10%–14%
Obesity Trends* Among U.S. AdultsBRFSS, 1989
Source: Behavioral Risk Factor Surveillance System, CDC
No Data <10% 10%–14%
Obesity Trends* Among U.S. AdultsBRFSS, 1990
Source: Behavioral Risk Factor Surveillance System, CDC
No Data <10% 10%–14% 15%–19%
Obesity Trends* Among U.S. AdultsBRFSS, 1991
Source: Behavioral Risk Factor Surveillance System, CDC
No Data <10% 10%–14% 15%–19%
Obesity Trends* Among U.S. AdultsBRFSS, 1992
Source: Behavioral Risk Factor Surveillance System, CDC
No Data <10% 10%–14% 15%–19%
Obesity Trends* Among U.S. AdultsBRFSS, 1993
Source: Behavioral Risk Factor Surveillance System, CDC
No Data <10% 10%–14% 15%–19%
Obesity Trends* Among U.S. AdultsBRFSS, 1994
Source: Behavioral Risk Factor Surveillance System, CDC
No Data <10% 10%–14% 15%–19%
Obesity Trends* Among U.S. AdultsBRFSS, 1995
Source: Behavioral Risk Factor Surveillance System, CDC
No Data <10% 10%–14% 15%–19%
Obesity Trends* Among U.S. AdultsBRFSS, 1996
Source: Behavioral Risk Factor Surveillance System, CDC
No Data <10% 10%–14% 15%–19% ≥20
Obesity Trends* Among U.S. AdultsBRFSS, 1997
Source: Behavioral Risk Factor Surveillance System, CDC
No Data <10% 10%–14% 15%–19% ≥20
Obesity Trends* Among U.S. AdultsBRFSS, 1998
Source: Behavioral Risk Factor Surveillance System, CDC
No Data <10% 10%–14% 15%–19% ≥20
Obesity Trends* Among U.S. AdultsBRFSS, 1999
Source: Behavioral Risk Factor Surveillance System, CDC
No Data <10% 10%–14% 15%–19% ≥20
Obesity Trends* Among U.S. AdultsBRFSS, 2000
Source: Behavioral Risk Factor Surveillance System, CDC
No Data <10% 10%–14% 15%–19% 20%–24% ≥25%
Obesity Trends* Among U.S. AdultsBRFSS, 2001
Source: Behavioral Risk Factor Surveillance System, CDC
No Data <10% 10%–14% 15%–19% 20%–24% ≥25%
Obesity Trends* Among U.S. AdultsBRFSS, 2002
Source: Behavioral Risk Factor Surveillance System, CDC
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GutBiology
Nutrition,Diet & Health
MolecularMicrobiology
Understanding and controlling bacterial foodborne pathogens
Good Guys
11
Bad guys
10,15
24
GutBiology
Nutrition,Diet & Health
MolecularMicrobiology
FoodBiophysics
Maintaining food quality with a healthy diet
Feelgood foods
oil7
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GutBiology
Nutrition,Diet & Health
MolecularMicrobiology
FoodBiophysics
Gut
IFR Science Skills Base
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New Research Leaders
●Systems Biology
●Gut Biology
●Molecular Immunology
●Molecular nutrition
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● ‘omics Transcriptomics –
microarrays Proteomics Metabolomics
● Imaging TEM, SEM, Light
Microscopy Nmr Atomic Force
Microscopy
IFR Technology Skills Base
15
11
Oh Me, Oh my – omics and Where’s Wally3
2
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Exploitation Platforms
●Sustainability of food chain Keith Waldron
●Magnetic Resonance Imaging Brian Hills
●Model Gut Martin Wickham
●National Collection of Yeast Cultures Ian Roberts
●Food Databanks Paul Finglas
●Microbial Ecology Tim Brocklehurst
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●Facilitates a knowledge-based industry
●Helps develops relationships between IFR and its industry stakeholders that bring mutual benefits
●Cost-effective knowledge-sharing
www.foodandhealthnetwork.com - promoting an environment where food Industry professionals can network with research scientists
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Activities
Regular Cluster meetings on relevant topics
Cross-cluster meetings on areas of more general interest at locations convenient to industry (North and South). Proposed topics now available on FHN stand
FHN Direct: 1:1 consultations on confidential basis at IFR or on-site
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●The Clusters & their Leaders
Allergy – Clare Mills
Co-product exploitation – Keith Waldron
Food Structure & Nutrition – Pete Wilde
Pathways to personalised nutrition – Siân Astley
Predictive Microbiology & Risk Analysis – Jòzsef Baranyi
Quality throughout Shelf-Life – Reg Wilson
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Food & Health Network “Direct”
●One-to-one collaboration with the food industry
●Your issues – our complementary skills
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Norwich Research Park
IFR
UEA Triangle
JIC
HospitalNNUH
UEA Main Campus
PBL
UEA● Institute of Health
Medical School● Computer Science● Chemistry & Pharmacy● Biology
PBL• Licensing• Patent Protection• Market Research
NNUH● Clinicians within IFR● Histo-pathology● Tissue Bank● Numerous depts
Youare
here
John Innes Centre• Plant/microbe genetics• Crop development
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European Agenda
●Member of Initiative Group (with Wageningen and Unilever) for development of a vision document for a
European Technology Platform: Food for Life
Food and Health Food Quality and
ManufacturingConsumer and the
integrated food chain
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● ‘omics Transcriptomics –
microarrays Proteomics Metabolomics
● Imaging TEM, SEM, Light
Microscopy Nmr Atomic Force
Microscopy
●Bioinformatics Statistics Modelling High-throughput
analysis
●Human Nutrition Unit
●National Collection of Yeast Cultures
IFR Technology Skills Base
8
12
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Strategic Plan: Vision and Mission
Mission
●Undertake international quality scientific research relevant to food and human health
●Work in partnership with others to provide underpinning science for consumers, policy makers, the food industry and academia
Vision
●to be a world-leading contributor to harnessing food for health and controlling food-related disease
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IFR
● The Institute of Food Research (IFR) is a not-for-profit company with charitable status
● Sponsored by the Biotechnology & Biological Sciences Research Council
IFR and IFR Enterprises Ltd are registered to the quality standard ISO 9001
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Strategic Plan: “Objectives”
●Gastrointestinal Tract Biology: Understanding gut health and function
●Nutrition, Diet and Health: Understanding how our diet influences our long-term health
●Food Innovation: Maintaining food quality with a healthy diet
●Food Safety: Understanding and controlling bacterial foodborne pathogens
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IFR
Turnover ~ £15m pa
● 190 scientific staff, 18 PhD students
● Admin Support joint with JIC
9.1
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Outputs
●High-quality science base Research papers
●Underpinning evidence for policy – especially for Government (FSA, Defra, DH) Influence on policy
●Knowledge Transfer – especially for industry Collaboration Licensing, spin-outs etc
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GI TractBiology
NutritionDiet & Health
FoodInnovation
FoodSafety
Mass Spectrom
etry
Met
abol
omic
s
Functional Genomics
Human Nutrition Unit
Ato
mic F
orce
Micro
scop
yC
on
foca
lS
EM
, T
EM
FTIR
Animal Facilities
BasicScience
Micro-biologists
Bio-chem
ists
An
alyt
ical
C
hem
ists
Ph
ysicists
Physiol-
ogists
Physical
Chemists
Pla
nt
Sci
enti
sts
Nutritionists
Social
Scientists
Mat
hemat
-
icia
ns
43
GI TractBiology
NutritionDiet & Health
FoodInnovation
FoodSafety
Mass Spectrom
etry
Met
abol
omic
s
Functional Genomics
Human Nutrition Unit
Ato
mic F
orce
Micro
scop
yC
on
foca
lS
EM
, T
EM
FTIR
Animal Facilities
Micro-biologists
Bio-chem
ists
An
alyt
ical
C
hem
ists
Ph
ysicists
Physiol-
ogists
Physical
Chemists
Pla
nt
Sci
enti
sts
Nutritionists
Social
Scientists
Mat
hemat
-
icia
ns
Allergy
Obesity
Emerging Pathogens
Microbiol safety of the food chain
Waste / Sustainability
Bioterrorism
Ageing Population
Quality in the food chain
Diet and Disease
Strategic Relevance
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GI TractBiology
NutritionDiet & Health
FoodInnovation
FoodSafety
Mass Spectrom
etry
Met
abol
omic
s
Functional Genomics
Human Nutrition Unit
Ato
mic F
orce
Micro
scop
yC
on
foca
lS
EM
, T
EM
FTIR
Animal Facilities
Micro-biologists
Bio-chem
ists
An
alyt
ical
C
hem
ists
Ph
ysicists
Physiol-
ogists
Physical
Chemists
Pla
nt
Sci
enti
sts
Nutritionists
Social
Scientists
Mat
hemat
-
icia
ns
ClostridiaGM identity
Authenticity
Micronutrientdeficiency
Pathogen Elimination
GM andNovel Foods
Colon Health
FSA
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Influence on policy
The institute has made important contributions to the development of UK policy on e.g.:
●Dietary fibre (throughout the 1990s)
●Fruits and vegetables (development of 5-a-day advice - 1998)
●n-3 fatty acid consumption (from fish - 1999)
●Mineral nutrition (1990s and 2000s)
●Colonic health (late 1990s)
●Shelf-life of chilled foods (2000s)
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Delivery
●Programmes
●Partnerships
●Exploitation Platforms
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Programmes
Shortform title Prog Leader
●GI tract biology and health Ian Johnson
●Commensals & microflora Mike Gasson
●Phytochemicals & Health Richard Mithen
●Micronutrients Sue F-Tait
●Personalised (mol) Nutrition to be appointed
●Structuring foods for health Clare Mills
●Pathogens: mol microbiol Jay Hinton
●Pathogens: Phys & Pred Ecol Mike Peck
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Internal Partnerships
●Bioinformatics and statistics Kate Kemsley
●Technologies for Systems Biology Transcriptomics
Tony Michael Proteomics Metabolomics
●Risk & Consumer Science Nigel Lambert
● Imaging Vic Morris
● [Support Units] [HNU, North SiteUEA]
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Research Collaborations
●Our scientific research collaboration stretches across the world through informal and formal partnerships. Examples:
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Molecular Microbiology
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Nutrition, Diet and Health
Obesity
Body Mass Index (BMI): a measure of an adult’s weight in relation to height, specifically the adult’s weight in kilograms divided by the square of his or her height in meters.
Obesity: having a very high amount of body fat in relation to lean body mass, or Body Mass Index (BMI) of 30 or higher.
Overweight: a BMI between 25 and 30.
Case 2: Obesity
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Gut Biology
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Norwich Research Park
IFR
UEA Triangle
JIC
HospitalNNUH
UEA Main Campus
PBL
UEA● Institute of Health
Medical School● Computer Science● Chemistry & Pharmacy● Biology
PBL• Licensing• Patent Protection• Market Research
NNUH● Clinicians within IFR● Histo-pathology● Tissue Bank● Numerous depts
Sainsbury Laboratory
Youare
here
57
GutBiology
Nutrition,Diet & Health
MolecularMicrobiology
FoodBiophysics
IFR Skills Base
58
Functional Genomics / Systems Biology
Genome SequencesPathogensSalmonella entericaCampylobacter jejuniClostridium botulinum
CommensalsLactococcus lactisLactobacillus johnsoniiBifidobacterium breve
L. LactisMG1363
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Bacterial Microarrays @ IFR 2006• “SALSA” 4 Salmonella serovars 5600 genes
• “ShE. Coli” 6500 genesE. coli O157 & Shigella flexneri
+ 150 EPEC/ ETEC virulence genes
• Campylobacter jejuni 1800 genes, plus plasmids
• Clostridium botulinum 3456 genes
• Lactococcus lactis 2587 genes
• Coming soon: Bifidobacterium breveLactobacillus johnsonii
6012 Macrophage J774-A.1 SL134404 Macrophage J774-A.1 SL1344
0.01
0.1
1
10
100 Normalized Intensity(log scale)
Normalised Macrophage infection 100
10
1
0.1
0.01
Salmonella Compendium Database 1.0
Macs 4,8,12hHeLa 2,4,6h
hns
pH3.0hilACD
MM-low glucose ATR pH5.5
phoP
SPI1 caught napping?
• Hierarchical clustering of EnviCom
• SPI1 genes cluster with 5 nap genes
• A co-regulatory mechanism?
• Do the nap genes play a role in invasion?
napFDHBC
SPI1
SPI1
GutBiology
Nutrition,Diet & Health
MolecularMicrobiology
FoodBiophysics
IFR Skills Base