insulin-like growth factor i: may have potential in insulin resistance

Is I Insulin-like growth factor I: may have potential in insulin resistance IV recombinant insulin-like growth factor I [IGF-I. somatomedin C: Amgen. Genentech. Fujisawal 3mg significantly reduced blood levels of glucose. insulin. C peptide and growth hormone when administered to a 13-year-old boy with Mendenhall's syndrome . The boy had severe diabetes. consistent with the syndrome. which was resistant to dietary oral hypogJycaemics and insulin. 'The short-term use of IGF-/ may . .. hal'e therapeutic benefits in patients with sel'ere insulin-resistant states.' QUln JD. Fisher BM . Paterson KR. Inoue -\. Beasta ll G H. e t 31. -\cute response to recombinant Insulin ·lik l' growth factor I in a pattent with \' lcndenhall' s syndro me. New Engla nd Journal of Med ic ine 323: 1425· 1426. 15 No\ 1990 ISS\' 0156-2703/ 90/ 1114-0001/ 0$01.00/ 0 1) Adi5 International Ltd 1 INPHARMA @14 Nor 1990

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Page 1: Insulin-like growth factor I: may have potential in insulin resistance

Is I Insulin-like growth factor I: may have potential in insulin resistance

IV recombinant insulin-like growth factor I [IGF-I. somatomedin C: Amgen. Genentech. Fujisawal 3mg significantly reduced blood levels of glucose. insulin. C peptide and growth hormone when administered to a 13-year-old boy with Mendenhall's syndrome. The boy had severe diabetes. consistent with the syndrome. which was resistant to dietary measu~es. oral hypogJycaemics and insulin. 'The short-term use of IGF-/ may . .. hal'e therapeutic benefits in patients with sel'ere insulin-resistant states.' QUln JD. Fisher BM . Paterson KR. In o ue -\. Beasta ll G H. e t 31. -\cute response to recombinant Insulin ·lik l' growth factor I in a pattent with \ 'lcndenhall' s syndro me. New Engla nd Journal of Med icine 323: 1425· 1426. 15 No\ 1990

ISS\' 0156-2703/ 90/ 1114-0001/ 0$01.00/ 0 1) Adi5 International Ltd

1 INPHARMA@14 Nor 1990

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