Solving complex testing issues.Ef f iciently, reliably, safely.

INTEGRATED CYTOMETRY SOLUTION

BR-9726B

COMPLEX PROTOCOLS

DIFFICULT TESTING PANELS

CONNECTING MULTIPLE PARAMETERSTO A SINGLE SAMPLE

RELIABILITY OF RESULTS

SAFE SAMPLE HANDLING

STREAMLINED DATAMANAGEMENT

Simplif ying f low cytometry processes through advanced automation.

COMPLEX PROTOCOLS

TEST PANELSMULTIPLE

PARAMETERS

AT BECKMAN COULTER,we know your busy discoveryprocess depends on developing

and applying testing protocolsthat deliver enhanced prognostic

and diagnostic value. So we,re offering a new breed ofbreakthrough automation solutions expressly designed tohelp you manage your testing processes efficiently, reliably,safely, and with peace of mind.

Automating tedious processes for faster, safer, more reliable results.

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FOR THE FIRST TIME, the IntegratedCytometry Solution offers a seamlesspre-analytical, analytical, and post-analyticalsolution coupled with complete LISconnectivity. By standardizing the five majorsteps a sample undergoes – and managingthe electronic communications between eachone – it delivers a progressive automatedsystem that simplifies and streamlinesworkflow processes, increases efficiencyand accuracy, accelerates throughput, andminimizes operator involvement.

WITH CONTINUOUSFEEDING of samples to theFP1000 Sample Preparation System,any run size proceeds smoothly andrapidly. At the same time, thesamples are tracked and verifiedthroughout the process, reducingerrors, re-runs and incorrect sampleIDs.The user determines whichreagents and lytic system to usebased on the protocol, and they areloaded into the FP1000. Additionally,the number of mixes can beprogrammed by the user, facilitatingaccurate reagent setup results, anddelivering unparalleled flexibility.

LEVERAGING many years of world-class expertise, our IntegratedCytometry Solution delivers a whole new level of capability to the flow cytometrylaboratory. By focusing on simplifying andstandardizing complex testing processes,it helps you manage arduous protocols, handledifficult testing panels, navigate the maze ofdata management, and ensure the mostreliable single-patient results with anunprecedented level of ease and confidence.

BARCODE tracking on the daughter tubes provides paperless positive ID throughoutthe process, while three carousels deliver high throughput for increased lab efficiency(up to 90 daughter tubes per hour in batch mode for tetraCXP). For reduced operatorinvolvement and increased safety, the FP1000’s unique gripping arm transports samplecarousels from storage to processing. By accessing sample tubes through cap piercing – aswell as automatically dispensing antibodies into the daughter tubes – technologists areprotected from potential sample exposure and reproducibility is increased.

THE SAMPLE ID, test request and demographic information are sent from the LIS and captured inthe Instrument Manager.† At the same time, the run information is sent to the FP1000 database. Complexpanels, protocols, reagents and procedures are automatically set up, and a worklist is generated. To ensureaccurate handling, data is transferred electronically from LIS to final results.This virtually eliminatestranscription errors and costly sample re-runs, while freeing valuable techs for more important tasks.

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WITH THE SAMPLES PROPERLY PREPARED, the carouselsare moved to the FC 500. The user locates the external worklist fileon the FP1000, and opens it, populating the CXPAcquisition Managerfor processing and barcode-based sample tracking. For enhancedflexibility in labs with multiple instruments, the worklist can besent via ethernet. It can also use native FC 500 or Excel formats,or a combination. To permit the operator to easily work withlistmode data during analysis, it’s stored in a user-created directory.With auto-setup capability, multi-color analysis using either singleor dual laser excitation, and the ability to use a variety of dyes,the award-winning FC 500 delivers unmatched versatility.

†Instrument Manager is a trademark of Data Innovations, Inc.

REALTIME OR LISTMODE DATA HANDLING, point-click gating,and 20-bit data acquisition are just a few of the ways the innovative FC 500and its revolutionary CXP software deliver accurate and easy-to-interpretresults —all of which can be printed at the FC 500 or uploaded to the LIS.

FOR THE UTMOST FLEXIBILITY AND SAFETY in howinformation is transmitted, password-protected results can bereviewed and verified at the Instrument Manager† workstationbefore uploading, or they can be passed on directly to the LIS.

THE INTEGRATEDCYTOMETRY SOLUTION appliesunmatched systemization to complexapplications, assuring accuracy in sampleand daughter tube identity, consistencyin analysis, and flexibility in protocols.

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THE INFORMATION MANAGERAUTOMATICALLY QUERIES theFC 500 database every15 minutes or whenneeded, which it then uses to create a resultssummary. This automation virtually eliminatestranscription errors, while freeing valuabletechs for more important tasks.

A FULLY AUTOMATED HIGH-THROUGHPUT SYSTEM.Integrated pre-analytical, analytical and post-analytical capabilities.Seamless interaction with the Laboratory Information System.Precise sample traceability throughout the process. And a longlegacy of leadership in flow cytometry. What does it all meanfor your busy lab?

Faster turnaround of patient samplesReduced operator interactionMore accurate and reproducible resultsHigh-reliability instrumentationStreamlined setupSafety in sample tracking and integrityReduced bio-hazard exposure Customizable data reporting options Easy access to thousands of reagentsWorldwide service and support teamsThe FC 500 with CXP software complies with the EuropeanUnion In Vitro Diagnostic Medical Device Directive 98/79/EC

LEADING THE CHARGE against life,s most challenging diseases,our comprehensiveline of integrated flow cytometry products use laser technology, optics, electronics andcomputers to identify and monitor a wide variety of illnesses.

Applications range from basic medical research to specialty testing and day-to-daydiagnostics. In basic research and bio-pharma areas, our leading-edge tools handleimmunology, cell function and physiology, cell cycle analysis, molecular biology, genetics,and microbial and plant cell analysis. In clinical research and patient care applications,they,re used for CD4 enumeration, leukemia/lymphoma analysis, stem cell enumerationfor bone marrow transplants, and cross matching for solid organ transplants.

Count on Beckman Coulter for a continuing pipeline of novel Integrated CytometrySolutions that fuse advanced science with enhanced economics, and deliver a new levelof functionality and efficiency to the laboratories of today and tomorrow.

For information on our comprehensive line of systems, please contact your localBeckman Coulter representative or visit our web site at www.beckmancoulter.com/ics

B2005-6681-CB-20 ©2005 Beckman Coulter, Inc. Printed in U.S.A. on recycled paper.