Integrative human cardiovascular control Danish Cardiovascular Research Academy

Ph.D. course

The Panum Institute/Rigshospitalet, University of Copenhagen

May 15 – 20, 2017

Monday 15/5 Panum Institute 31.01.60a

Topic and speaker

Background literature - assignments

8:30 - 9.00 Welcome and introduction to the program -presentation of participants and speakers

9.00 - 10.30 Integrative human cardiovascular physiology: A primer to hypothesis-driven research 1. Developing the question; Mechanisms of

exercise-induced Cardioprotection Peter Raven, PhD, University of North Texas, Fort Worth, TX, USA 2. 20 years of skin graft research – How we

got to where we are. Craig G. Crandall PhD, University of Texas Southwestern Medical Center, Dallas, Texas, USA

10.30 - 11.00 Refreshments 11.00 - 11.30 Animal Models for the Study of Autonomic

Cardiovascular Control Scott Smith PhD, Dallas, Texas USA

11.30 - 12.00 Lunch 12.00 - 16.00 Workshop: Hypothesis-driven research in

cardiovascular physiology: Presenting and discussion of participants’ projects. Introduction by Lars Nybo (15 min) followed by group work: 3-4 students (each with a speaker as “supervisor”): Students presents in a group: the projects and techniques of presentations are discussed (approx. 45 min for each presentation) – Carsten Lundby, Lars Nybo, Zeljko Dujic, Peter Raven.

Plan for groups – and schedule for presentations

Evening Social dinner at Bagsværd at 18.00 h., Adr: Skråvej 16, 2880 Bagsværd

Tuesday 16/5 Panum institute 31.01.60a

Central circulation Background literature - assignments

8.30- 9.30 Determination of cardiac output at rest and during exercise - Carsten Lundby PhD, Copenhagen and Johannes Van Lieshout MD, DMSc , University of Amsterdam, Holland

9.30 – 10.00 MRI Evaluation of Cardiac function and myocardial perfusion – Per L Madsen, MD, DMSc, Herlev

10.00 -10.45 Arterial baroreflex control of heart rate and blood pressure. Peter B Raven

10.45-11.15 Refreshments 11.15 – 12.15 Workshop: Cardiac output and blood

pressure regulation at rest and during exercise - baroreceptor reflex - Lars Nybo, Peter B Raven, James Fisher, Johannes Van Lieshout

Rigshospitalet dept. 2044, room 4264

12.15-12.45 Lunch 12.45-15.30 ECHO Doppler evaluations of the heart and

ultrasound assessment of peripheral circulation - Per L Madsen and Kim Bredahl, MD, PhD, Rigshospitalet

15.30-16.30 Discussion of the workshop and round-up of related presentations

Participants design of experiments – description of methods and set-up

Evening Social networking time on your own

Wednesday 17/5 Panum Institute 31.01.60a

Special circulations I - focus on cerebral blood flow and skin circulation

Background literature - assignments

8.30 – 9-15 Sympathetic activity and methods to assess sympathetic nerve activity . Paul Fadel PhD, Texas, USA

9. 15– 10.45 Near infrared spectroscopy for evaluation of cerebral and muscle oxygenation, methodological considerations . Henrik Sørensen, MD, DMSc, Copenhagen

10.45 – 11.15 Refreshments 11.15 – 11.45 Cerebral blood flow and oxygenation, static

and dynamic autoregulation, and relation to - orthostatic stress - Johannes Van Lieshout

11.45 –12.30 Cardiovascular regulation during heat stress, changes in skin and cerebral perfusion, orthostatic tolerance and cardiac output . Lars Nybo and Craig Crandall

12.30 – 13.30

Lunch

13.30 – 14.00 How do we "sense" oxygen during exercise? A radical perspective Damian Bailey PhD, University of South Wales, UK

14:00-16.30 Workshop: Cerebral blood flow and orthostatic tolerance - Lars Nybo and Johannes Van Lieshout

Participants design of experiments - description of methods and set-up

Evening Social networking time on your own

Thursday 18/5 Rigshospitalet 2.11.2

Special circulations II - muscle perfusion, oxygenation and metabolism

Background literature – assignments

8:30 - 9:00 Methods for determination of blood flow Stefan Mortensen, University of Southern Denmark

9:15 - 10.00 1. Regulation of skeletal muscle blood flow: role of vasodilators - Ylva Hellsten PhD, Copenhagen 2. Skeletal muscle blood flow regulation: sympatholysis - Stefan Mortensen, Odense

10.00 - 10.30 Refreshments 10.30 - 11.00 The exercise pressor reflex - interaction

between cardiac output and muscle metabolism and blood flow. James Fisher, University of Birmingham, UK

11.00 – 11.30 Neural control of the circulation during exercise: central command Jon Williamson, Southwestern Medical Center, Dallas, Texas, USA

11.30 - 12.00 Cerebral and leg blood flow during exercise - influence of dehydration and heat stress. Jose Gonzalez-Alonso PhD, Brunel University, UK

12.00-12.30 Lunch 12.30 - 13:00 Endothelia function in health and disease -

Sisse Ostrowski MD, PhD, DMSc, Copenhagen

13.00 –13.30 Genetic influence on the circulation Niels V Olsen MD, DMSc, Copenhagen

13.30 –14.00 Central blood volume and maintenance of cardiac output, pressure and organ perfusion during surgery.

Niels H. Secher, MD, DMSc 14.00 -14.30 The orthostatic challenge as evaluated in the

giraffe - Chr. Aalkjaer, MD, DMS, Aarhus.

14.30 –15.00 Organ blood flow and metabolism Gerrit van Hall PhD, Copenhagen

Friday 19/5 Rigshospitalet 2.11.2

Pathophysiological responses and special issues

Background literature - assignments

9:00-12:00 Demonstration: Cardiovascular regulation in the pig. Rikard Ambrus, M. D, Rigshospitalet

At the Panum Institute 16.3

12.00-13.00 Lunch 13.00-16.00 Social event

Saturday 20/5 Panum Institute 31.01.60a

Agenda Background literature - assignments

9.00 – 9.30 Cardiovascular control in the very small - Simon Hüttel-Sørensen, Rigshospitalet

9:30 - 10.30 Integrative cardiovascular aspects - Lars Nybo (questions. and discussion of topics from the week)

10.30 - 12.00 Group examination - Lars Nybo 12.00 - 13.00 Lunch and evaluation

Course secretary: Jaime Latorre Finkelstein,

Email: Jaime.finkelstein@regionh.dk,

Telephone daytime: +45 3545 6120/private: +45 2735 1573