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  • 8/7/2019 Inter Reality in the Treatment of Psychological Stress in Soldiers- Rationale and Protocol of the Inter Stress Project-1

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    Coping with Posttraumatic Stress Disorders in Returning Troops,

    Wiederhold, B.K.

    NATO Science for Peace and Security Series - E:

    Human and Societal Dynamics.

    Volume 68, 2010

    DOI: 10.3233

    221

    Interreality for the treatment of psychological

    stress in soldiers:

    rationale and protocol of the INTERSTRESS

    project

    Andrea GAGGIOLIa,b1

    , Alessandra GORINIa, Brenda WIEDERHOLD

    c, Federica PALLAVICINI

    a,d, Simona

    RASPELLIa, Davide ALGERI

    aand Giuseppe RIVA

    a,b

    aIstituto Auxologico Italiano IRCSS, Applied Technology for Neuro-Psychology Laboratory, Milan, Italy

    bDepartment of Psychology, Catholic University of Milan, Italy

    cVirtual Reality Medical Center, San Diego, CA, USA

    dUniversity of Milano Bicocca, Italy

    Abstract. The use of virtual reality is not new in the treatment of psychological stress and anxiety disorders:

    virtual worlds are used to facilitate the activation of the stressful events during the exposure therapy.

    However, during the therapy, the virtual worlds are new and distinct realms, separate from the real-life

    emotions and behaviors. In fact, the patients behavior in the virtual world has no direct effects on his/her

    real-life experience, and emotions and problems experienced by the patient in the real world are not directly

    addressed in the virtual exposure. In this paper we present the INTERSTRESS project, a new technological

    paradigm for the treatment of psychological stress in soldiers, based on interreality. The main feature ofinterreality is a twofold link between the virtual and the real worlds: (a) behavior in the physical world

    influences the experience in the virtual one; (b) behavior in the virtual world influences the experience in the

    real one. This is achieved through 3D shared virtual worlds; biosensors and activity sensors (from the real to

    the virtual world); and personal digital assistants and/or mobile phones (from the virtual world to the real one).

    We will describe the different technologies involved in the interreality approach and the clinical rationale of

    the protocol. To illustrate the concept of interreality in practice, a clinical scenario regarding a soldier affected

    by acute psychological stress will be also presented and discussed.

    Keywords. Psychological stress, virtual worlds, interreality, battlefield stress.

    Introduction

    The INTERSTRESS project intends to design, develop and test an advanced ICT (Information andCommunication Technology) based solution for the assessment and treatment of psychological stress

    occurring in soldiers. According to JAMA [1] psychological stress occurs when an individual perceives that

    environmentaldemands tax or exceed his or her adaptive capacity. Stressful experiences are conceptualized

    as person-environment transactions, whose result is dependent on the impact of the external stimulus on the

    individual. This process is mediated by:

    - the persons appraisal of the stimulus: when faced with a stimulus, the subject evaluates its potential

    threat (primary appraisal) establishing if it is stressful, positive, controllable, challenging or irrelevant.

    1Corresponding Author: Istituto Auxologico Italiano IRCSS, Applied Technology for Neuro-Psychology Laboratory. Via Pellizza

    da Volpedo, 41, 20149 Milan, Italy; E-mail: [email protected].

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    Coping with Posttraumatic Stress Disorders in Returning Troops,

    Wiederhold, B.K.

    NATO Science for Peace and Security Series - E:

    Human and Societal Dynamics.

    Volume 68, 2010

    DOI: 10.3233

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    - the personal, social and cultural resources available: facing a significant stimulus, the second appraisal

    follows, which is an assessment of the individuals coping resources and options. Secondary appraisals

    address what one can do about a specific situation.

    - the efficacy of the coping efforts: if required by the appraisal process the individual starts a problem

    management phase aimed at regulation of the external stimulus.

    Stressful events can vary in a number of ways: duration, severity, predictability, degree of loss of

    control, self-confidence of the person experiencing the stress, and suddenness of onset. Accidents, natural

    disasters, and military combat can cause high levels of stress and may result in a stress disorder. Stress may

    also be the result of a personal crisis, such as being raped or bereaved. Stress disorders that require clinical

    attention - adjustment disorders, acute stress disorder, and post traumatic stress disorder (PTSD) - are

    pathological because they go beyond expected, normal emotional and cognitive reactions to severe personal

    challenges. In the adjustment disorder, a recent increase in life stress precedes what is usually a temporary

    maladaptive reaction. In the acute stress disorder and PTSD, changes in behavior, thought, and emotion arelinked to an extremely traumatic stressor. Stressful events can influence the pathogenesis of physical diseases

    by causing negative affective states (e.g., feelings of anxiety and depression), which in turn exert direct

    effects on biological processes or behavioral patterns that influence disease risk. The way in which people

    cope with stress depends on their vulnerability and resilience. Vulnerability increases the likelihood of a

    maladaptive response to stress; resilience decreases it. Having a positive self-concept, enjoying new

    experiences, and having good interpersonal relationships contribute to resilience.

    Today, most clinicians recognize the need for more research on treatments of the stress-related

    disorders. They also acknowledge the need to treat stress-related disorders with a combination of the

    following components:

    acceptance of what the individual is going through;

    education and training regarding useful coping responses to stressors;

    overcoming fear of trauma-related memories;

    cognitive restructuring (e.g., questioning and revising trauma-related schemas).

    According to the Cochrane Database of Systematic Reviews [2; 3; 4], the best validated approachcovering both stress management and stress treatment is the Cognitive Behavioral Therapy (CBT) approach.

    This approach may include both individual and structured group interventions (10 to 15 sessions) interwoven

    with didactics. It also includes in-session didactic materials and experiential exercises (learning to cope with

    daily stressors (psychological stress) or traumatic events (PTSD), and optimizing one's use of personal and

    social resources) and out-of-session assignments (practicing relaxation exercises and monitoring stress

    responses). The CBT approaches also:

    - use group members and group leaders as role models (for positive social comparisons and social

    support);

    - encourage emotional expression;

    - replace doubt appraisals with a sense of confidence by means of cognitive restructuring;

    - hone skills in anxiety reduction (by progressive muscle relaxation or diaphragmatic breathing and

    relaxing imagery), interpersonal conflict resolution, and emotional expression (by means of assertion

    training).

    The CBT package thus includes both problem-focused (e.g., resource optimization and better planning)

    and emotion-focused (e.g., relaxation training, use of emotional support) coping strategies. Even if CBT is

    the best validated approach for the treatment of stress, further clinical research is needed to tune existing

    protocols and fully exploit its clinical potential. As suggested by Cohen and colleague in their JAMA review

    [1]: The development of interventions that can reduce the behavioral and biological sequelae of

    psychological stress and the demonstrated efficacy of such interventions in randomized clinical trials would

    provide critical data on the clinical importance of this work.

    Another critical point is that, because stress-related problems stem from a wide variety of stressors, the

    selection of an appropriate treatment depends on a number of factors associated with the way in which

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    individuals experiencing their own difficulties. The main challenge in treating stress is that it is a very

    personal experience. For these reasons the focus for assessment, prediction and treatment has to be the

    situated experience of the patient.

    1.1.The Project ObjectivesThe main aim of the INTERSTRESS project is to develop a completely new concept for the treatment of

    psychological stress defined interreality. This innovative approach combines CBT with a hybrid, closed-loop

    empowering experience bridging real and virtual worlds.

    From the technological point of view interreality is based on the below devices/platforms:

    3D individual and/or shared virtual worlds (3DWs) aimed to provide objective assessments and

    provision of motivating feedback. They will be immersive (in the health care centre) or non-immersive (at

    home) role-playingexperiences in which one or more users mutually interact through their avatars. 3DWs

    provide an advanced social networkservice combined with the general aspects of fully immersive 3D virtual

    spaces. Residents can explore the worlds, meetother users, socialize, and participate in individual and group

    activities;

    personal biomonitoring system (PBS) that connects the real world to the virtual one allowing objective

    and quantitative assessment and decision support for treatment. Typically 3DWs are closed worlds that do

    not reflect the real activities and the status of their users. In interreality, instead, the PBS is used to track the

    emotional/health status of the user and to influence his/her experience in the virtual world (aspect, activity

    and access). Data coming from the PBS will be integrated by a data fusion module and analyzed by a

    Decision Support System. The PBS will consist of independent lycra-based wearable bands for the

    examination of the physiological and behavioral signs. In this way the link between the real and the virtual

    worlds will be both in real-time - allowing the development of advanced dynamic biofeedback settings - or

    not, to ensure health tracking also in situations where an Internet connection is not immediately available;

    personal digital assistants (PDAs) and/or mobile phones that connect the virtual world with the real one

    giving an objective assessment and provision of warnings and motivating feedbacks. As explained before,

    virtual worlds are closed and have not a direct impact on the real life of the user. On the contrary, in the

    interreality paradigm, the social and individual user activity in the virtual world has a direct link with the

    users life through a mobile phone/digital assistant. The clinical use of these technologies in the interreality

    paradigm is based on a closed-loop concept that involves the use of technology for assessing, adjusting

    and/or modulating the emotional regulation of the patient, his/her coping skills and appraisal of the

    environment (both virtual, under the control of a clinician, and real, facing actual stimuli) based on a

    comparison of the patients behavioral and his/her physiological responses with a baseline (Figure 1).

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    Human and Societal Dynamics.

    Volume 68, 2010

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    Figure 1. The INTERSTRESS subsystem

    These devices are integrated around two subsystems: the clinical platform (used for the inpatienttreatment, and fully controlled by the therapist) and the personal mobile platform (the real world support,

    available to the patient and connected to the therapist) that allow to:

    a. monitor the patient behavior and his/her general and psychological status, through an early detection

    of symptoms of critical evolutions and a timely activation of the appropriate feedback;

    b. monitor the response of the patient to the treatment, supporting the doctors in their therapeutic

    decisions.In conclusion, in the INTERSTRESS approach, behaviors in the physical world influences the

    experience in the virtual world, and behaviors in the virtual world influences the experience in the real

    world.

    More in details, the specific objectives of the project are the following:

    Objective 1: to design, develop and test an advanced ICT based solution for the diagnosis and

    treatment of psychological stress.Actual CBT approach can be crudely described as imagining evokes emotions and the meaning of the

    associated feelings can be changed through reflection and relaxation. The interreality-based approach

    suggests the following alternative: controlled experience evokes emotions that result in meaningful new

    feelings which can be reflected upon and eventually changed through reflection and relaxation (Figure 2).On one side, the assessment will be conducted continuously in the virtual and real worlds tracking the

    individuals behavioral and emotional status over time in the context of realistic task challenges. On the other

    side, the information will be constantly used to improve both the appraisal and the coping skills of the patient

    through a conditioned association between the effective performance state and the task execution behaviors.

    The clinical platform and the personal mobile platform will provide:

    - an objective and quantitative assessment of symptoms obtained by biosensors and behavioral analysis:

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    Human and Societal Dynamics.

    Volume 68, 2010

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    monitoring the patients behavior and his/her psychological status, the system will provide an early detection

    of symptoms and a timely activation of feedback in a closed loop approach;

    - a decision support for treatment planning through data fusion and detection algorithms that monitor the

    patients response to the treatment, supporting the doctors in their therapeutic decisions;- a provision of warnings and motivating feedback to improve the compliance and the long-term

    outcome: the sense of presence provided by this approach affords the opportunity to deliver behavioral,

    emotional and physiological self-regulation training in an entertaining and motivating way.

    Figure 2. The interaction between real and virtual worlds

    Objective 2: to obtain an objective and quantitative assessment of psychological stress symptoms.a) Using biosensors and behavioral analysis. A wireless Personal Biomonitoring System (PBS) will

    collect, fuse, analyze, and visualize data originating from various sensors integrated to different service

    infrastructures. Specifically, the PBS will unobtrusively perform an ecological tracking of full body motion

    through a 3D wearable motion analysis platform that integrate the heart rate variability (HRV), the

    electrodermal response (EDR) and the peripheral temperature, as well as the EEG. Stressful event

    recognition is the most challenging goal since it involves going from raw signals to events related to the

    users behavior, physical state, mental state, context, communication with others, etc. Algorithms will be

    developed for the detection and recognition of specific trigger events/ external stimuli that have

    discriminating potential and may be used by a decision support system for treatment planning and

    contextualized guidelines and provisions.

    b) Identifying new biomarkers for the evaluation of the interreality therapeutic outcome. These

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    biomarkers can be measured in blood and/or spittle using existingtechnologies.

    Objective 3: to design and develop a decision support system for treatment planning through data

    fusion and detection algorithms.

    The decision support system will be trained:

    - by the therapist, using the patients responses in the virtual environments;

    - by the patient, by pressing a stress button in the real world context.

    In the therapists office, the system will collect data from different sensors during the virtual reality

    experience and will integrate them using a data fusion technique to facilitate the assessment process. These

    data will be used by the therapist to initially train the decision support system. On the other side, in the real

    world setting, the system will provide contextualized support using advice (warnings and feedback) and

    exercises (homework). The patient will train the decision support system by pressing a stress button. This

    involves also the development of a flexible, scalable, context-aware, secure, and resilient architecture andtechnologies to enable dynamic management policies that ensure end-to-end secure transmission of data

    across heterogeneous local infrastructures and networks, including dynamic networks of tiny insecure sensor

    devices.

    Objective 4: to test the new interreality paradigm based on a dual-change closed-loop approach.

    How is it possible to change a patient? Even if this questions has many different answers, ingeneral change

    comes through an intense focus on a particular instance or experience [5]: by exploring it as much as

    possible, the patient can relive all of the significant elements associated with it (i.e., conceptual, emotional,

    motivational, and behavioral) and make them available for a reorganization.

    Within this general model we have the insight-based approach of psychoanalysis, the schema-

    reorganization goals of cognitive therapy or the enhancement of experience awareness in experiential

    therapies. According to Safran and Greenberg [6], behind each specific therapeutic approach we can find two

    different models of change: bottom-up and top-down (Figure 3). These two models of change are focused on

    two different cognitive systems, one for information transmission (top-down) and the other for conscious

    experience (bottom-up), both of which may process sensory inputs. Even if many therapeutic approaches are

    based on just one of the two change models, a therapist usually requires both. Our claim is that bridging

    virtual experiences fully controlled by the therapist, used to learn coping skills and emotional regulation -

    with real experiences that allows both the identification of any critical stressors and the assessment of what

    has been learned using advanced technologies (virtual worlds, biosensors and advanced PDA/mobile

    phones) is the best way to address both these two change models.

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    Figure 3. The Top-Down and Bottom-Up approaches to clinical change

    The INTERSTRESS project is interested in validating this approach in the real clinical setting related to

    the battlefield stress giving: (i) an objective and quantitative assessment of symptoms using biosensors and

    behavioral analysis; (ii) a decision support system for treatment planning based on data fusion and detection

    algorithms and (iii) warnings and motivating feedbacks to improve compliance and long-term outcome. To

    our knowledge, this is the first attempt worldwide to use this approach in healthcare.

    1.2.The Battlefield Stress: When Acute Stress Afflicts SoldiersBattlefield stress is the consequence of man being exposed to the hostile environment of combat [7].

    Combat stress is specifically caused by man's feat of the dangers of combat, and is fueled and tempered by

    other variables such as morale, cohesion, fatigue, confidence, training and intensity of the combat. The

    history shows that a stressed soldier may be a significant problem. In the battles of Faid-Kasserine, the first

    major engagements of US forces in World War II, 20 to 34 percent of the casualties were caused not by

    direct wounds and disease but by battlefield stress [8]. And the situation is not significantly changed. As

    demonstrated recently by Morgan and colleagues [9], acute stress may impair working memory and visuo-

    spatial ability even in elite soldiers. In their study, including 184 Special Operations warfighters, stress

    exposure impaired visuo-spatial capacity and working memory of the sample, potentially reducing

    performance of duty. For these reasons, stress management is a critical issue for the Army. The Field Manual

    26-2 provides different techniques and consideration for the management of stress in the US Army operation

    [10]. Specifically, it depicts three different and increasing levels of support (Stress Management Module)

    based on installation resources:

    - Level one: it is designed as a minimum program that includes placement of

    pamphlets/brochures/posters around the military community, making sure that welcome packets are provided

    to all new members and ensuring sponsorship of new arrivals;

    - Level two: it includes level one plus community education classes (learning new skills and activities)

    and the use of radio/TV spots;

    - Level three: it includes level one and level two plus specific intervention programs conducted byqualified health care professionals. These programs include, as the traditional CBT programs, relaxation

    techniques, problem solving, cognitive restructuring and clarification of life goals.

    The limitations of this approach is twofold. First, given the limited number of qualified professionals on

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    the battlefield, treatment is often as simple as giving soldiers time to rest for a few hours or days, to get a

    shower and some sleep, and to talk about the feelings they have in the presence of a counselor. Second, in the

    civilian population there is a broad spectrum of techniques available; however, the available techniques are

    much less when applied to the battlefield. Because the duration of stress and the intensity of the battle

    usually also reduce imagination and relaxation abilities, the stress coping strategies requested in the military

    context are even more challenging.

    In the next paragraph we will suggest the application of the interreality paradigm for the provision of

    advanced coping techniques for the treatment of an acute stress disorder occurred in a soldier involved in the

    last conflict in Afghanistan.

    1.3.The INTERSTRESS Project in PracticeThe clinical scenarioPaolo is a 30-year-old Italian soldier. Four months ago he went to Afghanistan for a Peace Mission,

    immediately after his girlfriend decided to interrupt their 5-year relationship. Ten days later his command

    was involved in a terrible explosion and 5 of his comrade-in-arms died in front of his eyes. One of them was

    also one of his best friend. He was immediately sent back home, but everybody closed to him noticed that he

    was completely changed. In particular, Paolo had difficulty accepting the true reality that his girlfriend left

    him and his best friend died. Furthermore, he was convinced he lost his job because he felt himself unable to

    combat again. These events caused him to think he has lost two of the most important things of his life,

    making him feel totally alone. Moreover, Paolo felt like no one can help him: their parents live far away

    from him and his friends cannot understand. He though that those who have not directly experienced such a

    situation can never really understand it.

    What makes the situation even more difficult is the fact that Paolo believes his coping efforts were

    ineffective: he believes he had no control over the situation and insufficient resources to cope with such it.

    Paolo was exposed to a situation of chronic stress and was manifesting many of the difficulties associated

    with psychological stress: indeed he appeared to have effectively dealt with previous stressors but not the

    current one (Figure 4).

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    Figure 4. A schematic view of the INTERSTRESS rationale

    1.3.1 The applied protocol

    Paolo will first need to accept what he is going through. This will require a cognitive restructuring

    activity to allow for re-appraisal of the event followed by education and training regarding useful coping

    responses to the type of stressors he is dealing with.

    Considering the severity of the situation, the medical military staff decides to send Paolo a therapist.

    When he arrives, the therapist welcomes him giving him an immediate sense of being less alone and makes

    him begin to feel better.After a short interview and some paper-and-pencil self-report questionnaires, the therapist decides to

    apply the INTERSTRESS protocol. He helps Paolo to wear biosensors to monitor his physiological

    parameters, explaining him how they work and beginning the education process. Then the therapist

    introduces Paolo to the first virtual world, called the Experience Island (Figure 5) where he was

    progressively exposed to a virtual traumatic situation similar to the one that he had experienced in

    Afghanistan. Within this virtual environment Paolo had to walk in the city streets and to drive a military jeep

    in different conditions (from a very safe condition to a very dangerous one). In the meantime the data fusion

    system allows the therapist to directly index how the various stressors are impacting Paolos

    neurophysiological reactions, thus providing an objective understanding of the different stressors and their

    importance and impact on his well-being.

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    At the end of the clinical session, the therapist prescribes Paolo some homework. This, the therapist

    explains, will allow Paolo to be an active participant in his own well-being and to practice the skills he has

    started to learn, thus making them become more readily available to him during real-life stressful situations.

    The homework: First Paolo is asked to expose himself to the critical situation recorded in the virtual

    world and displayed on her PDA. Then he must expose himself to the real world situation. In real world

    situations, the biosensors will track his response, and the Decisions Support System, according to the

    difference from his baseline profile, will provide positive feedback and /or warnings.

    Finally the therapist explains Paolo that he can press a stress button in the PDA if he feels excessively

    stressed: this will record the most critical experiences that will be discussed with the therapist in the next

    face-to-face session. In this way the therapist will teach the patient how to effectively handle the future

    situational stressors.

    At the start of any new session, the therapist uses the compliance data and warning log to define the

    structure of the clinical work. Also, the Decision Support System will analyze the stressful situationsindicated by Paolo to understand more what happened and the context in which they occurred.

    By showing the patient what situations caused him the most physiological arousal, he often develop a

    new awareness, that brings on added insight and allows for self-treatment to proceed more effectively.

    Moreover, utilizing new skills and coping mechanisms taught by the therapist, the patient is able to employ

    these skills prior to stress becoming overwhelming. This is where Virtual Worlds have an immensely

    beneficial advantage.

    In the following sessions, the virtual world is not only used for assessment but also for training and

    education. Within the environment, Paolo has the opportunity to practice different coping mechanisms:

    relaxation techniques, emotional/relational management and general decision-making and problem- solving

    skills. For example, if Paolos real world outcome is poor (e.g., he can not do a task without feeling irritable

    and impatient when his friends and relatives) he will experience again a similar experience in the virtual

    environment and will be helped in developing specific strategies for coping with it. Later, in the relaxation

    areas he will enjoy a relaxing environment and learn some relaxation procedures. As with any new skill, as

    Paolo has the opportunity to practice the coping skills, they become second nature, and these new behaviors

    replace the older, outdated behavior patterns which caused the initial overwhelming stress.

    The therapist now prompts Paolo to visit another virtual world the Learning Island. Within it, Paolo

    learns how to improve his stress management skills and receives information about the main causes of stress

    and about how to recognize its symptoms, to learn stress-management skills such as better planning, to learn

    stress relieving exercises such as relaxation training and to get the information needed to succeed.

    After some other sessions, the therapist invites Paolo to participate in a virtual community where he will

    meet other patients who suffer of the same problem. Within this virtual world called Community Island-

    Paolo has the opportunity to discuss and share his experience with other users who may be facing a similar

    situation.

    However, sometimes Paolo experiences new critical situations that may raise his level of stress. For

    example, he had to discuss with her boss in the morning and this left him feeling very upset during the rest of

    the day. At the end of the work day, when he returned home he felt very excited/stressed and nervous and the

    Decision Support System alerted him twice about this. Both the signals were sent also to the therapist who

    appeared on his PDA display as an avatar suggesting Paolo to practice some of the acquired relaxation

    techniques.

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    Figure 5. The virtual worlds used in the interreality approach

    Paolo is scheduled to see the therapist the next day. The therapist asks him if the avatar was helpful and

    his answer is positive: the avatar gave him an emotional boost appearing in the exact moment he needed it

    and suggesting him helpful relaxation techniques he had previously learned.

    Then the therapist asks Paolo about the experienced difficulties. In particular, the therapist wants to get

    information about where Paolo was: what he was doing and thinking, and what his reactions were. Paolo

    relates all the information to the therapist: he was in his office and was quarrelling with a colleague, causinghis stress level to become higher. The information provided by Paolo is compared by the therapist with the

    information provided by the Decision Support System. Any difference is explored and interpreted.

    By working as a team, Paolo is taught a new skill of interpretation, and his therapist is more able to

    understand any differences in his self-perception of stress and the objective measurements shown by the

    DSS. This will help to more effectively individualize and guide future training and therapy sessions.

    In the following sessions, Paolo tells the therapist that he feels better thanks to being able to frequently

    experience stressful situations within safe virtual environments. He also says that meeting other people in the

    community has helped him to find much-needed support and to discover new strategies to manage his

    emotions. With regard to this, he also says the community experience has helped him with seeing the stressor

    in a new perspective. Moreover, by listening to others experiences, he was facilitated in adopting new

    coping skills.

    The therapist helps Paolo to cognitively restructure the critical situation, which now he is more able to

    deal with through the strategies he has learned. The last session ends with advice on the prevention ofrelapse.

    In general, the patient reports that this kind of highly personalized treatment is very useful because

    allows to experience different stressful situations specifically related to his own traumatic experience in a

    safe virtual environment. Paolo also reports that receiving correct information about the disorder and meeting

    other people is useful for him to find the needed psychological support and to discover new strategies to

    manage his negative emotions. Finally, having full-time support through the PDA increases his self-efficacy

    and the benefit obtained from the therapy.

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    1.4.ConclusionIn the last year virtual reality and virtual worlds have been extensively used to facilitate the activation of

    certain emotions and to expose patients to specific critical events during the exposure phase of a CBT

    protocol. However, the actual virtual reality-based CBT protocols for the treatment of anxiety related

    disorders do not address the following issues:

    1. Virtual worlds are new and distinct realms, separate from the emotions and behaviors experienced by

    the patients in the real world;

    2. The treatment protocol is not customized to the particular characteristics of the single patient.

    3. CBT focuses on patients thoughts and behaviors but does not address relationship change and self-

    efficacy.

    On the contrary, the interreality protocol integrates the assessment and treatment within a hybrid

    environment, bridging the physical and virtual worlds. The clinical use of interreality is based on a closed-loop concept that involves the use of technology for assessing, adjusting, and/or modulating the emotional

    regulation of the patient, his or her coping skills, and appraisal of the environment based on a comparison of

    the patients behavioral and physiological responses with a training or performance criterion:

    1. The assessment is conducted continuously throughout the virtual and real experiences.

    2. The information is constantly used to improve both the emotional management and the coping skills

    of the patient.

    Finally, the idea to test the interreality protocol on the military members affected by anxiety disorders

    caused by the excessive battlefield stress is perfectly in line with the 2006 Army Modernization Plan, an

    operationally based report that describe the modernization and investment strategies for providing the best

    capabilities to the US Army, supporting a sustained transformation process [11] based on the use of the

    emerging technologies.

    In conclusion, although CBT focuses on directly modifying the content of dysfunctional thoughts

    through a rational and deliberate process, interreality focuses on modifying an individuals relationship with

    his or her thinking through more contextualized experiential processes based on: an extended sense of

    presence, an extended sense of community, and a real-time feedback between the physical and virtual

    worlds. The proposed approach needs to be tested on a sample of patients before being considered a valid

    solution for the treatment of anxiety disorder. This is what we will intend to do thanks to the recently funded

    European project, INTERSTRESSinterreality in the management and treatment of stress-related disorders

    (FP7-247685), that will offer the right context to test and tune the presented ideas.

    Acknowledgments

    This work was partially supported by the European-funded project INTERSTRESSInterreality in

    the management and treatment of stress-related disorders (FP7-247685).

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