interaksi alel dan rekombinasi
TRANSCRIPT
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Interaksi Alel dan
Rekombinasi
UIN Maulana Malik Ibrahim Malang
Andik Wijayanto M.Si
TIK: Memahami proses interaksi alel, rekombinasi, dapat
membuat linkage map dan analisisnya
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Interaksi Alel
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The phenotype and
genotype ratios are
the same (1:2:1) like
codominant but this
is due to incomplate
dominant (the
dominant allel does
not fully contribute
the phenotype in a
heterozygote
(weakened or
diluted)
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Dominance
Epistasis
Involves intra-allelic gene interaction.
Involves inter-allelic gene interaction.
One allele hides the effect of other allele at the same gene pair.
One gene hides the effect of other gene at different gene loci.
Epistasis
Interaction between alleles at different loci
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Epistatic
alleles
Hypostatic
alleles
Phenotypic
Expression
aa bb b
aa BB, Bb B
AA, Aa Bb, Bb, bb A
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Penghitungan Interaksi Alel
• Diperoleh data biji Pisum sativum: O E
Kuning halus 315 9/16X556 313
Hijau halus 108 3/16X556 104
Kuning keriput 101 3/16X556 104
Kuning keriput 32 1/16X556 35
total 556
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X2 = (315-313)2 + (108-104)2 + (101-104)2 + (32-35)2
313 104 104 35
= 0.013 + 0.154 + 0.087 + 0.257
= 0.511
• Ho : P1 = P2 = P3 . . . . Pn
• H1 : P1 ≠ P2 , P3 . . . . Pn
dF = n-1 = 4-1 = 3, selang kepercayaan 95%
Xtabel = 7.82, X2hitung ≤ X2
tabel
maka H0 diterima (sesuai dg hukum Mendel)
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Penghitungan Interaksi Alel
B. Diperoleh data pasien CAD (hubungan gen p53 terhadap penyakit CAD):
Gen p53 COD Jumlah
Ya Tidak
Aktif 20 50 70
Tidak Aktif 10 40 50
Jumlah 30 90 120
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X2 = (20-17.5)2 + (50-52.5)2 + (10-12.5)2 + (40-37.5)2
17.5 52.5 12.5 37.5
= 1.143
• Ho : P1 = P2 = P3 . . . . Pn
• H1 : P1 ≠ P2 , P3 . . . . Pn
dF = n-1 = 2-1 = 1, selang kepercayaan 95%
X2tabel = 3.84, X2
hitung ≤ X2tabel
maka H0 diterima (aktif tidaknya gen p53 tidak berpengaruh terhadap ekspresi penyakit CAD)
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In 1931, Harriet Creighton and Barbara McClintock were studying two
genes of corn that they knew were both located on chromosome 9. One
affected seed color (C, colored; c, colorless) and the other affected
endosperm composition (Wx, waxy; wx, starchy)
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Your ALTITUDE does not depend on your
APTITUDE, but depend on your
ATTITUDE, so you can MAGNITUDE
Ketinggian atau harga diri Anda tidak
ditentukan oleh bakat, posisi, jabatan
atau harta Anda, tapi terletak pada SIKAP
Anda. Sehingga dengan itu Anda bisa
membuat perubahan-perubahan yang
bermakna dalam kehidupan