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INTERDISCIPLINARYMEDICALSCIENCESMODULEAdvancedIMSLab4900F/G

CourseoutlineforFall2019

Western University is committed to a thriving campus; therefore, your health andwellness matter to us! The following link provides information about the resourcesavailable on and off campus to support students: https://www.uwo.ca/health/ Yourcoursecoordinatorcanalsoguideyoutoresourcesand/orservicesshouldyouneedthem.

ThiscourseisgenerouslysupportedbytheScienceStudentDonationFund.

GrantsfromtheFundhaveallowedforthepurchaseofequipmentintegraltoteachingthiscourse.

1. Coursedetailsandimportantdates

Section Day Tutorial Lab001 Tuesday

FNB2220 11:30am–12:20pm MSB113/117 1:30pm–5:20pm002 Wednesday

ClassesstartSeptember5thandendDecember6th.TheStudydaysareDecember7thand8th.ThefinalexamperiodisDecember8thto19th.

2. Interactingwithyourinstructors,teachingassistants,andpeers

Nicole Campbell is your course coordinator and instructor, but this course relies onparticipationofmanyteammembersincludingteachingassistantsandYOU!Communicationiskeyforthiscourseandbelowyouwillfinddetailsaboutinteractingwithourteam.

Thecoursehasbeendesignedforstudentstointeractinlabbenchteams.Youwillworkwiththesemembersatyourownpaceandassisteachotherwithprotocolsandothertasks.Wewillspendalotoftimeinthelabtogethereachweekandthereoftenperiodsofdowntimeduringincubations.Usethetimewiselytodiscussassignmentexpectationsorjustcatchuponlifewithyourlabmates,instructors,orteachingassistants.

Theremaybetimesthroughoutthesemesterwhenyouneedtocontactyour instructororteaching assistants. In an attempt to keep the course organized and maintain work-lifebalance,weaskthatyouonlysendmessagesusingthe“email”tabonOWL.Ourteamwilldoourbest tovalueyour time, soplease return the favourandrefer to thisdocument,othercourseresources,orchatwithyourpeersbeforesendinganemail.

Notallquestions/concernscanbeaddressedduringclasstimeorviaemail.Ifatanypoint,youwouldliketobookanappointmentwithyourinstructor,youcandosousingthelinkbelow.Yourinstructorisheretoguideyouthroughthecourse,butshecanalsobeamentorifneeded.Donothesitate tobookanappointment to check inordiscussyourprogress.https://dr-c.youcanbook.me

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3. CourseDescriptionandDesign

Medical Sciences 4900F/G is offered jointly by Basic Medical Science Departments, thislaboratory course introduces students to a variety of techniques used inmedical research.Majortopicsincludetissueculture,realtimePCR,biochemicalassays,histology,andmedicalimaging. The laboratory provides an introduction to research,with emphasis on hands-onexperience.4labhours;1tutorialhour;0.5creditLaboratorycoursesareclassifiedasexperientiallearning.;therefore,thiscourseisdesignedtoengagestudentsinauthenticlearning.Studentswillexplorevariousbasicscienceandclinicalscenarios that relate to diabetes research. All course material will be posted to OWL:http://owl.uwo.ca.AnychangeswillbeindicatedontheOWLsiteanddiscussedwiththeclass.StudentswithOWLissuesshouldcontacttheComputerSupportCentreat519-661-3800orwww.itshelp.uwo.ca

4. LearningOutcomes

Uponsuccessfulcompletionofthiscourse,studentswillbeableto:

• Skillfullyandsafelyperformawiderangeofpracticallaboratorytechniquesfroma variety of basic medical science disciplines, including cell culture, biochemicalassays,westernblotting,andreal---timePCR.

• Clearly and concisely record, summarize, analyze, and interpret results from anexperiment.

• Construct and deliver well-organized, and logical information making use ofappropriate delivery techniques to communicate scientific knowledge to the targetaudience.

• Collaborateeffectivelybydemonstratingrespectforothers,respectfordifferentpointsofview,beliefs,andvalues,andtakingonleadership,whereappropriate.

• Create a research proposal based on a relevant area of focus within a specificdisease that includes a literature review and justification for the experimentaldesign.

• Evaluate relevant real-worldscenariosand/orproblemsby integratingperspectivesfrommedicalsciencedisciplinestomakeinformeddecisions.

5. Tutorialandlaboratorysessions

The tutorials and labs for this course have been designed to support the desired learningoutcomes.Therefore,studentsmustattendalltutorialandlabsessionsandarriveontime.Wearereasonablepeoplethoughandunderstandthatstudentsmighthavetomissasessionduetoillnessoraninterview.Ifthisisthecase,justsendyourcoursecoordinatoranemailASAP to arrange attending an alternate session.When in doubt, show up to the other labsectionifpossible.Ifyouareunabletoattendeithersessioninagivenweek,youwillneedtoattendthelabmake-update,whichisscheduledforFriday,December6th(timeTBD).Ifthereisanassessmentassociatedwithdataobtainedfromalabandthestudentmissesthelab,theycantalktotheirinstructortoborrowdatatocompletetheassessment.Thestudentwillreceivethatgradeoncetheyhavemadeupthemissedlabattheendofthesemester.Thetutorialstakeplacebeforethescheduledlaboratoriesandwillserveasanopportunitytodiscussthecontent.Studentswillalsoworkwiththeirlabbenchteamstopreparefortheirlaboratorysession.

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LaboratorySchedule

The following schedule outlines the tutorial and laboratory sessions for the semester. Thesessionsaredividedupintomolecularlaboratories(firsthalf)andclinicalscenarios(secondhalf)togivestudentsbroadexposuretomedicalscienceresearch.

Week Dates Tutorial Laboratory1 N/A Notutorial Nolab

2 Sept10/11 Introductionandcompetencyassessment Lab1:LabSkills

3 Sept17/18 Cellculture:passagingandcounting Lab2:Cellculture

4 Sept24/25 Proteinisolationandquantification

Lab3:ProteinisolationandBCAassay

5 Oct1/2 WesternblotI:denaturing,loading,transferring Lab4:WesternblotI

6 Oct8/9 WesternblotII:antibodiesandimaging

Lab5:WesternblotII+progressreport(labbenchteam)

7 Oct15/16 qPCR:isolatingRNA,reversetranscription(RT),qPCR Lab6:RNAisolation,RT,qPCR

8 Oct22/23 Reviewandpreparationforskillsassessment

Labskillsassessmentwithassignedtimeperiod

9 Oct29/30 Posterpresentations+individualassessment(scheduledtime)10 Nov5/6 FallReadingWeek

11 Nov12/13 ResearchethicsatWesternUniversity

Ethicaldecision-makingsimulation

12 Nov19/20 Renalphysiology,anatomy,andimaging Diabetescasestudy

13 Nov26/27 Peerreviewandcommitteeintroductions Grantpanelpreparation

14 Dec3/4 Notutorial Grantpaneltoevaluatepeerproposalsanddeterminefunding

6. Resources

Studentsmustbringtheirpersonalprotectiveequipmenttoalllabsunlessotherwisestated.Thisincludesalabcoatandsafetyglasses.

AllcoursematerialswillbeprovidedonOWL.Thereisnorequiredtextbookforthiscourse.Alaboratorymanualhasbeengeneratedbyyourinstructorandlabcoordinator.Youwillbeabletopurchasethisresourceandasharpieduringthefirstscheduledlaboratorysession.Youare expected to bring themanual to all scheduled “labs”. To assist youwith this course, awebsitehasbeendevelopedbythecoursecoordinatorandformerIMSstudents.Onthissite,you will find access to resources that will help you with your scientific communication.Studentsarenotrequiredtoaccessthewebsitebutareencouragedtotakeadvantageoftheresources.Youwillbegivenaccesstothesitebecauseyouareenrolledinthiscourse.Thesiteis:www.iamims.com

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7. Evaluation

Below is the evaluation breakdown for the course. No deviations will be made unlessdiscussedwithallmembersofthecourse.Deadlineswillbefinalizedduringthesemesterwithstudents,buttheweeksassignmentsareduehavebeenpostedinthetablebelow.

NotethatOWLdeadlinesaresetfor11:55pm

Adetailedandcomprehensivesetofpoliciesandregulationsconcerningexaminationsandgrading can be found at the following website:http://www.westerncalendar.uwo.ca/PolicyPages.cfm?Command=showCategory&PolicyCategoryID=5&SelectedCalendar=Live&ArchiveID=#SubHeading_73

Component Format Weighting DateDigitallabbook/reflections OWLonline 15% Throughouttheterm3Ps* Mixed 5% ThroughoutthetermProgressreport Written 10% Week6Labskillsassessment Practicalinlab 10% Week8

Sciencecommunicationsymposium

Posterpresentation**+teamevaluation

Oral/written 15%Week9

Oral‘defense’(individual) Oral 10%

GrantproposalOutline Mixed 5% Week4Proposal Written 20% Week12Panel Oral/written 10% Week14

*3P’s=prepared,professional,participation.Studentsareexpectedtobepreparedforalllabs(thisincludesbringingyourPPEtoeverylab),actprofessionalduringalllabs,actsafelyduringalllabs,andparticipateinlabswhenpossible.Therefore,allstudentsstartwith5%andwilllosemarksiftheydonotmeetexpectations(seeOWLfordetails).

**Studentswillcreateandpresenttheirposterswiththeirlabbenchteams.

à24/7policy forallassessments!Afteranassignment is returned,wait24hoursbeforecontactingyourevaluatorsothatyoucandigestthefeedback.Toensureatimelyresponse,reachoutwithin7daysfollowingthereleaseoftheassessment.

University-widegradedescriptors:

A+ 90-100 OnecouldscarcelyexpectbetterfromastudentatthislevelA 80-89 SuperiorworkwhichisclearlyaboveaverageB 70-79 Goodwork,meetingallrequirements,andeminentlysatisfactoryC 60-69 Competentwork,meetingrequirementsD 50-59 Fairwork,minimallyacceptableF below50 Fail

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8. StatementonAcademicOffences

“Scholasticoffencesaretakenseriously,andstudentsaredirectedtoreadtheappropriatepolicy,specifically,thedefinitionofwhatconstitutesaScholasticOffence,atthefollowingwebsite:http://www.uwo.ca/univsec/pdf/academic_policies/appeals/scholastic_discipline_undergrad.pdf

9. Turnitinandothersimilarityreviewsoftware

AllassignmentswillbesubjecttosubmissionfortextualsimilarityreviewtothecommercialplagiarismdetectionsoftwareunderlicensetotheUniversityforthedetectionofplagiarism.Studentswillbeabletoviewtheirresultsbeforethefinalsubmission.Allpaperssubmittedfor such checkingwill be included as source documents in the reference database for thepurposeofdetectingplagiarismofpaperssubsequentlysubmittedtothesystem.Useoftheservice is subject to the licensing agreement, currently between Western University andTurnitin.com(http://www.turnitin.com).

10. AbsencefromCourseCommitments

AcademicConsiderationforStudentAbsencesIfyouareunabletomeetacourserequirementduetoillnessorotherseriouscircumstances,youmustseekapproval fortheabsenceassoonaspossible.Approvalcanbegrantedeitherthrough aself-reportingof absence or via theAcademicCounselling unit. TheAcademicCounsellingislocatedinNCB280,andcanbecontactedatscibmsac@uwo.ca.NEW!! For further information, please consult the university’s policy on academicconsideration for student absences as there are updates to the academic considerationprocedures.https://www.uwo.ca/univsec/pdf/academic_policies/appeals/Academic_Consideration_for_absences.pdf

Self-reportingconsiderationscoveryoufor48hours(yesterday+todayortoday+tomorrow).Yourinstructorwillreceivenotificationofyourconsiderationandyouareexpectedtosubmityourmissedworkwithin24hoursoftheendofyour48-hourperiod.

AccommodationforReligiousHolidays

The policy on Accommodation for Religious Holidays can be viewed at the following link:https://www.uwo.ca/univsec/pdf/academic_policies/appeals/accommodation_religious.pdf

SpecialExaminationsASpecialExaminationisanyexaminationotherthantheregularexamination,anditmaybeofferedonlywiththepermissionoftheDeanoftheFacultyinwhichthestudentisregistered,in consultation with the instructor and Department Chair. Permission to write a SpecialExaminationmaybegivenonthebasisofcompassionateormedicalgroundswithappropriatesupporting documents. To provide an opportunity for students to recover from thecircumstances resulting in a Special Examination, the University has implemented SpecialExaminationsdates.Thesedatesaswellasotherimportantinformationaboutexaminations

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and academic standing can be found at the following link:http://www.uwo.ca/univsec/pdf/academic_policies/exam/definitions.pdf

11. AcademicPoliciesandStatements

AccessibilityStatement

Pleasecontact thecourse instructor ifyourequirematerial inanalternate formator ifyourequireanyotherarrangementstomakethiscoursemoreaccessibletoyou.YoumayalsowishtocontactServicesforStudentswithDisabilities(SSD)at661-2111x82147foranyspecificquestionregardinganaccommodationorreviewThepolicyonAccommodationforStudentswithDisabilities.

CellPhoneandElectronicDevicePolicy

The Schulich School of Medicine & Dentistry is committed to ensuring that testing andevaluationareundertakenfairlyacrossallourdepartmentsandprograms.Foralltestsandexams,itisthepolicyoftheSchoolthatanyelectronicdevices,i.e.,cellphones,tablets,cameras,oriPodarestrictlyprohibited.ThesedevicesMUSTbelefteitherathomeorwiththestudent’sbag/jacket at the front of the room andMUST NOTbe at the test/exam desk or in theindividual’spocket.Anystudentfoundwithoneoftheseprohibiteddeviceswillreceiveagradeofzeroonthetestorexam.Non-programmablecalculatorsareonlyallowedwhenindicatedbytheinstructor.Theprogramisnotresponsibleforstolen/lostorbrokendevices.

CopyrightandAudio/VideoRecordingStatement

Coursematerial producedby faculty is copyrighted and to reproduce thismaterial for anypurposes other than your own educational use contravenes CanadianCopyright Laws. Youmust always ask permission to record another individual and you should never share ordistributetherecording.CorrespondenceStatementInaccordancewiththepolicy,http://www.uwo.ca/its/identity/activatenonstudent.html,the centrally administered e-mail account provided to students will be considered theindividual’sofficialuniversitye-mailaddress.Itistheresponsibilityoftheaccountholdertoensure that e-mail received from the University at his/her official university address isattendedtoinatimelymanner.

RoundingofMarksStatement

AcrosstheBasicMedicalSciencesUndergraduateEducationprograms,westrivetomaintainhighstandardsthatreflecttheeffortthatbothstudentsandfacultyputintotheteachingandlearningexperienceduringthiscourse.Allstudentswillbetreatedequallyandevaluatedbasedonlyontheiractualachievement.Finalgradesonthiscourse,irrespectiveofthenumberofdecimalplacesused inmarking individual assignments and tests,will be calculated toonedecimalplaceandroundedtothenearestinteger,e.g.,74.4becomes74,and74.5becomes75.MarksWILLNOTbebumpedtothenextgradeorGPA,e.g.a79willNOTbebumpeduptoan80,an84WILLNOTbebumpeduptoan85,etc.Themarkattainedisthemarkyouachieved,andthemarkassigned;requestsformark“bumping”willbedenied.

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12. SupportServices

AcademicCounselling(ScienceandBasicMedicalSciences):http://www.uwo.ca/sci/counselling

AppealProcedures:http://www.uwo.ca/univsec/pdf/academic_policies/appeals/appealsundergrad.pdf

RegistrarialServices:http://www.registrar.uwo.ca

StudentDevelopmentServices:http://www.sdc.uwo.ca

StudentHealthServices:http://www.shs.uwo.ca/

USCStudentSupportServices:http://westernusc.ca/services/