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INTERNATIONAL CONFERENCE ON GENOMICS & PROTEOMICS ORGANIZING COMMITTEE CHIEF PATRON Dr. E. Gopinathan PATRONS Dr. K. Prabhakaran Nair Dr. N. Ganesan Dr. T. P. Somasundaran Dr. C.B. Shoban CHAIRMAN Dr. Md. Anaul Kabir CONVENOR Dr. A. Santhiagu CO-CONVENORS Dr. Rajanikant G. K. Dr. Aswati Nair INTERNATIONAL ADVISORY COMMITTEE Dr Stephanie McArdle, Nottingham Trent University,UK Prof. Willium Oetting, University of Minnesota, USA Dr. Arshad Majid, Michigan State University, USA Dr Mike Dempsey, The Manchester Metropolitan University, USA Dr. Zulfiqar Ahmad, East Tennessee State University, USA Dr. Shyam Biswal, J. Hopkins Bloomberg School of Public Health, USA Dr. Rajeev S Samant, Mitchell Cancer Institute, USA Dr. T. Ramasami, Secretary, DST, New Delhi Dr. Rajesh Luthra, Head, HRDG, CSIR Dr. T.S.Rao, Advisor, DBT, New Delhi Dr. R.K. Mishra, CCMB, Hyderabad Dr. Rambir Singh, Advisor, DST, New Delhi Dr. P. Jayadeva Bhat, IIT-Bombay Dr. K.B. Ramachandran, IIT-Madras Dr. D. Panda, IIT-Bombay Dr. Pritish Sarkar, Senior Scientist (R&D), Biocon India Ltd, Bangalore Dr. Abraham T. Mathew, NIT Calicut LOCAL ORGANIZING COMMITTEE Dr. Lillykutty Jacob Sri K. Saseendran Dr. Naseer M.A Dr. S. Chandrakaran Dr. G. Unnikrishnan Dr. P.C. Subramaniam Dr. Priya Chandran Dr. S. Jayaraj Dr. V. Sivasubramanian Dr. Revathi Rajagopalan Dr. P. Chandrasekharan K Dr. Prabhakaran Paleri Dr. Sandhya Rani Dr. T.K. Suresh Babu Dr. Prem Raj Pushpakaran Dr. K. Rathinasamy Dr. Suchitra Organized by SCHOOL OF BIOTECHNOLOGY National Institute of Technology Calicut Kerala, India-673 601 ADDRESS FOR CORRESPONDENCE Dr. A. Santhiagu Convenor-ICGP-2011 School of Biotechnology National Institute of Technology Calicut- 673 601, Kerala Email: [email protected] Mobile: +91-9048094350 REGISTRATION FORM Name (in block letters): Designation: Affiliation: Mailing Address: Phone: Fax: Email: Mobile: Title of Paper: Payment details: Demand Draft no.: Date of issue: Bank/Branch: Amount: Accommodation required : Yes/No Date: Signature Place: (Proforma typed in A4 sheets can be filled, signed and sent to the Convenor. Demand Drafts should be made in favour of INTERNATIONAL CONFERENCE ON BIOTECHNOLOGY– 2011, NIT CALICUT “, payable at Calicut, Kerala. Chanakya Hall, NITC JULY 14 - 16. 2011

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INTERNATIONAL CONFERENCE

ON

GENOMICS & PROTEOMICS ORGANIZING COMMITTEE CHIEF PATRON Dr. E. Gopinathan

PATRONS Dr. K. Prabhakaran Nair Dr. N. Ganesan Dr. T. P. Somasundaran Dr. C.B. Shoban CHAIRMAN Dr. Md. Anaul Kabir

CONVENOR Dr. A. Santhiagu

CO-CONVENORS Dr. Rajanikant G. K. Dr. Aswati Nair INTERNATIONAL ADVISORY COMMITTEE Dr Stephanie McArdle, Nottingham Trent University,UK Prof. Willium Oetting, University of Minnesota, USA

Dr. Arshad Majid, Michigan State University, USA Dr Mike Dempsey, The Manchester Metropolitan University, USA

Dr. Zulfiqar Ahmad, East Tennessee State University, USA Dr. Shyam Biswal, J. Hopkins Bloomberg School of Public Health, USA Dr. Rajeev S Samant, Mitchell Cancer Institute, USA

Dr. T. Ramasami, Secretary, DST, New Delhi Dr. Rajesh Luthra, Head, HRDG, CSIR Dr. T.S.Rao, Advisor, DBT, New Delhi Dr. R.K. Mishra, CCMB, Hyderabad Dr. Rambir Singh, Advisor, DST, New Delhi Dr. P. Jayadeva Bhat, IIT-Bombay Dr. K.B. Ramachandran, IIT-Madras Dr. D. Panda, IIT-Bombay Dr. Pritish Sarkar, Senior Scientist (R&D), Biocon India Ltd, Bangalore Dr. Abraham T. Mathew, NIT Calicut

LOCAL ORGANIZING COMMITTEE

Dr. Lillykutty Jacob Sri K. Saseendran Dr. Naseer M.A Dr. S. Chandrakaran Dr. G. Unnikrishnan Dr. P.C. Subramaniam Dr. Priya Chandran Dr. S. Jayaraj Dr. V. Sivasubramanian Dr. Revathi Rajagopalan Dr. P. Chandrasekharan K Dr. Prabhakaran Paleri Dr. Sandhya Rani Dr. T.K. Suresh Babu Dr. Prem Raj Pushpakaran Dr. K. Rathinasamy Dr. Suchitra

Organized by

SCHOOL OF BIOTECHNOLOGY National Institute of Technology Calicut

Kerala, India-673 601

ADDRESS FOR CORRESPONDENCE

Dr. A. Santhiagu Convenor-ICGP-2011

School of Biotechnology National Institute of Technology

Calicut- 673 601, Kerala Email: [email protected]

Mobile: +91-9048094350

REGISTRATION FORM

Name (in block letters):

Designation:

Affiliation:

Mailing Address:

Phone: Fax:

Email: Mobile:

Title of Paper:

Payment details:

Demand Draft no.: Date of issue:

Bank/Branch: Amount:

Accommodation required : Yes/No

Date: Signature

Place:

(Proforma typed in A4 sheets can be filled, signed and sent to

the Convenor. Demand Drafts should be made in favour of

“INTERNATIONAL CONFERENCE ON BIOTECHNOLOGY–

2011, NIT CALICUT “, payable at Calicut, Kerala.

Chanakya Hall, NITC

JULY 14 - 16. 2011

ABOUT THE INSTITUTE Calicut Regional Engineering College Calicut Regional Engineering College Calicut Regional Engineering College Calicut Regional Engineering College was setup 50 years back in 1961 with a mission was setup 50 years back in 1961 with a mission was setup 50 years back in 1961 with a mission was setup 50 years back in 1961 with a mission to develop high quality technical education and to develop high quality technical education and to develop high quality technical education and to develop high quality technical education and personnel with a sound footing on basic engi-personnel with a sound footing on basic engi-personnel with a sound footing on basic engi-personnel with a sound footing on basic engi-neering principles, technical and managerial neering principles, technical and managerial neering principles, technical and managerial neering principles, technical and managerial skills, innovative research capabilities, and ex-skills, innovative research capabilities, and ex-skills, innovative research capabilities, and ex-skills, innovative research capabilities, and ex-emplary professional conduct to lead and to use emplary professional conduct to lead and to use emplary professional conduct to lead and to use emplary professional conduct to lead and to use technology for the progress of mankind, adapt-technology for the progress of mankind, adapt-technology for the progress of mankind, adapt-technology for the progress of mankind, adapt-ing themselves to changing technological envi-ing themselves to changing technological envi-ing themselves to changing technological envi-ing themselves to changing technological envi-ronment with the highest ethical values as the inner strength. Later in 2007, CREC ronment with the highest ethical values as the inner strength. Later in 2007, CREC ronment with the highest ethical values as the inner strength. Later in 2007, CREC ronment with the highest ethical values as the inner strength. Later in 2007, CREC was renamed as National Institute of Technology Calicut (NITC) by an Act of Parlia-was renamed as National Institute of Technology Calicut (NITC) by an Act of Parlia-was renamed as National Institute of Technology Calicut (NITC) by an Act of Parlia-was renamed as National Institute of Technology Calicut (NITC) by an Act of Parlia-ment (Act 29 of 2007) and declared as a technical institution of national importance.ment (Act 29 of 2007) and declared as a technical institution of national importance.ment (Act 29 of 2007) and declared as a technical institution of national importance.ment (Act 29 of 2007) and declared as a technical institution of national importance.

ABOUT THE SCHOOL

Dealing with one of the most revo-Dealing with one of the most revo-Dealing with one of the most revo-Dealing with one of the most revo-

lutionary and beneficial interdisciplinary lutionary and beneficial interdisciplinary lutionary and beneficial interdisciplinary lutionary and beneficial interdisciplinary

science, School of Biotechnology envisages science, School of Biotechnology envisages science, School of Biotechnology envisages science, School of Biotechnology envisages

to create a contemporary, innovative and to create a contemporary, innovative and to create a contemporary, innovative and to create a contemporary, innovative and

inspiring platform to carve out quality pro-inspiring platform to carve out quality pro-inspiring platform to carve out quality pro-inspiring platform to carve out quality pro-

fessionals providing them with total access fessionals providing them with total access fessionals providing them with total access fessionals providing them with total access

to exploit the exotic laboratory facilities to exploit the exotic laboratory facilities to exploit the exotic laboratory facilities to exploit the exotic laboratory facilities

and entitled to be guided by well versed and experienced faculties. It has research fa-and entitled to be guided by well versed and experienced faculties. It has research fa-and entitled to be guided by well versed and experienced faculties. It has research fa-and entitled to be guided by well versed and experienced faculties. It has research fa-

cilities in all conventional and frontier areas like molecular & cell biology, enzymol-cilities in all conventional and frontier areas like molecular & cell biology, enzymol-cilities in all conventional and frontier areas like molecular & cell biology, enzymol-cilities in all conventional and frontier areas like molecular & cell biology, enzymol-

ogy & bioprocess technology, plant molecular biology, cancer biology, neurobiology, ogy & bioprocess technology, plant molecular biology, cancer biology, neurobiology, ogy & bioprocess technology, plant molecular biology, cancer biology, neurobiology, ogy & bioprocess technology, plant molecular biology, cancer biology, neurobiology,

biomodelling & drug design and immunotechnology.biomodelling & drug design and immunotechnology.biomodelling & drug design and immunotechnology.biomodelling & drug design and immunotechnology.

OBJECTIVES Genomics and proteomics are at the Genomics and proteomics are at the Genomics and proteomics are at the Genomics and proteomics are at the cutting edge of modern research in the field of cutting edge of modern research in the field of cutting edge of modern research in the field of cutting edge of modern research in the field of biotechnology. The future of genomics and pro-biotechnology. The future of genomics and pro-biotechnology. The future of genomics and pro-biotechnology. The future of genomics and pro-teomics holds a great deal of promise for man-teomics holds a great deal of promise for man-teomics holds a great deal of promise for man-teomics holds a great deal of promise for man-kind. Technology and resources generated by kind. Technology and resources generated by kind. Technology and resources generated by kind. Technology and resources generated by the Human Genome Project and other genomics the Human Genome Project and other genomics the Human Genome Project and other genomics the Human Genome Project and other genomics research are already having a major impact on research are already having a major impact on research are already having a major impact on research are already having a major impact on life sciences research. The applications of ge-life sciences research. The applications of ge-life sciences research. The applications of ge-life sciences research. The applications of ge-nomics range from Molecular medicine, Energy nomics range from Molecular medicine, Energy nomics range from Molecular medicine, Energy nomics range from Molecular medicine, Energy sources and environmental applications to sources and environmental applications to sources and environmental applications to sources and environmental applications to bioarchaeology, anthropology, evolution and bioarchaeology, anthropology, evolution and bioarchaeology, anthropology, evolution and bioarchaeology, anthropology, evolution and forensics. Proteomics came into prominence forensics. Proteomics came into prominence forensics. Proteomics came into prominence forensics. Proteomics came into prominence after 1997 and quickly became a popular re-after 1997 and quickly became a popular re-after 1997 and quickly became a popular re-after 1997 and quickly became a popular re-search avenue, holding much greater importance search avenue, holding much greater importance search avenue, holding much greater importance search avenue, holding much greater importance than scientists initially suspected. Proteomics than scientists initially suspected. Proteomics than scientists initially suspected. Proteomics than scientists initially suspected. Proteomics as a complement to genomics, involves the largeas a complement to genomics, involves the largeas a complement to genomics, involves the largeas a complement to genomics, involves the large----scale analysis of proteins and their scale analysis of proteins and their scale analysis of proteins and their scale analysis of proteins and their structure with applications in medical diagnosis, cancer prediction and discovering structure with applications in medical diagnosis, cancer prediction and discovering structure with applications in medical diagnosis, cancer prediction and discovering structure with applications in medical diagnosis, cancer prediction and discovering new molecular targets for accelerated drug discovery. The main objective of the con-new molecular targets for accelerated drug discovery. The main objective of the con-new molecular targets for accelerated drug discovery. The main objective of the con-new molecular targets for accelerated drug discovery. The main objective of the con-ference is to discuss the progress, achievements and the future direction of the interre-ference is to discuss the progress, achievements and the future direction of the interre-ference is to discuss the progress, achievements and the future direction of the interre-ference is to discuss the progress, achievements and the future direction of the interre-lated fields of genomics and proteomics. The conference will serve as a platform to lated fields of genomics and proteomics. The conference will serve as a platform to lated fields of genomics and proteomics. The conference will serve as a platform to lated fields of genomics and proteomics. The conference will serve as a platform to bring together students, academicians and researchers to share their innovative ideas bring together students, academicians and researchers to share their innovative ideas bring together students, academicians and researchers to share their innovative ideas bring together students, academicians and researchers to share their innovative ideas and experience in these exciting fields.and experience in these exciting fields.and experience in these exciting fields.and experience in these exciting fields.

POST SYMPOSIUM TOURS Calicut, an important city in State of Kerala, found a place in the World Calicut, an important city in State of Kerala, found a place in the World Calicut, an important city in State of Kerala, found a place in the World Calicut, an important city in State of Kerala, found a place in the World History with the discovery of Sea route to India in 1498 by the Portuguese navigator History with the discovery of Sea route to India in 1498 by the Portuguese navigator History with the discovery of Sea route to India in 1498 by the Portuguese navigator History with the discovery of Sea route to India in 1498 by the Portuguese navigator Vasco Da Gama. Basking in the idyllic setting Vasco Da Gama. Basking in the idyllic setting Vasco Da Gama. Basking in the idyllic setting Vasco Da Gama. Basking in the idyllic setting of the serene Arabian Sea on the west and the of the serene Arabian Sea on the west and the of the serene Arabian Sea on the west and the of the serene Arabian Sea on the west and the proud peaks of the Wayanad hills on the east, proud peaks of the Wayanad hills on the east, proud peaks of the Wayanad hills on the east, proud peaks of the Wayanad hills on the east,

CalicutCalicutCalicutCalicut is known for itsis known for itsis known for itsis known for its serene serene serene serene beaches, lush green countryside, his-beaches, lush green countryside, his-beaches, lush green countryside, his-beaches, lush green countryside, his-toric sites, calm backwaters, wildlife toric sites, calm backwaters, wildlife toric sites, calm backwaters, wildlife toric sites, calm backwaters, wildlife sanctuaries, rivers and ayurvedic sanctuaries, rivers and ayurvedic sanctuaries, rivers and ayurvedic sanctuaries, rivers and ayurvedic treatment. treatment. treatment. treatment.

CLIMATE Calicut weather and climate Calicut weather and climate Calicut weather and climate Calicut weather and climate is almost pleasant throughout the is almost pleasant throughout the is almost pleasant throughout the is almost pleasant throughout the year. The evenings are usually pleas-year. The evenings are usually pleas-year. The evenings are usually pleas-year. The evenings are usually pleas-ant due to offshore winds. During ant due to offshore winds. During ant due to offshore winds. During ant due to offshore winds. During July, it is monsoon and hence the July, it is monsoon and hence the July, it is monsoon and hence the July, it is monsoon and hence the weather is rainy and cool. The place weather is rainy and cool. The place weather is rainy and cool. The place weather is rainy and cool. The place does not experience chilly mornings does not experience chilly mornings does not experience chilly mornings does not experience chilly mornings or evenings and the place has an av-or evenings and the place has an av-or evenings and the place has an av-or evenings and the place has an av-erage temperature of 28erage temperature of 28erage temperature of 28erage temperature of 28oooo to 30to 30to 30to 30ooooCCCC

CONFERENCE EVENTS Invited lectures Invited lectures Invited lectures Invited lectures Oral presentationsOral presentationsOral presentationsOral presentations Poster presentationsPoster presentationsPoster presentationsPoster presentations

TOPICS FOR ORAL/POSTER PRESENTATION The Organizing committee invites unpublished research/review papers with The Organizing committee invites unpublished research/review papers with The Organizing committee invites unpublished research/review papers with The Organizing committee invites unpublished research/review papers with applications of proteomics and genomics in the following area for presentation during applications of proteomics and genomics in the following area for presentation during applications of proteomics and genomics in the following area for presentation during applications of proteomics and genomics in the following area for presentation during the proceedings of the conference. the proceedings of the conference. the proceedings of the conference. the proceedings of the conference.

- Animal Biotechnology

- Bioinformatics/Computational Biology

- Bioprocess & Downstream processing

- Enzyme technology

- Biopharmaceutical technology

- Cell Biology

- Genetic Engineering

- Immunotechnology

- Nanobiotechnology

- Protein Engineering

REGISTRATION The registration fees are as follows.The registration fees are as follows.The registration fees are as follows.The registration fees are as follows.

1. Academic Staff ( Indian) : Rs.1500 2. Academic Staff (Foreign) : US $75 3. Students (Indian) : Rs.750 4. Students (Foreign) : US $50 5. R &D organizations (Indian) : Rs.2000 6. R &D organizations (Foreign) : US $100 AAAAllllllll tttthhhheeee ppppaaaarrrrttttiiiicccciiiippppaaaannnnttttssss ooooffff tttthhhheeee ccccoooonnnnffffeeeerrrreeeennnncccceeee aaaannnndddd aaaaccccccccoooommmmppppaaaannnnyyyyiiiinnnngggg mmmmeeeemmmmbbbbeeeerrrrssss aaaarrrreeee rrrreeeeqqqquuuuiiiirrrreeeedddd ttttoooo rrrreeeeggggiiiisssstttteeeerrrr bbbbyyyy ggggiiiivvvviiiinnnngggg tttthhhheeeeiiiirrrr ddddeeeettttaaaaiiiillllssss aaaassss ppppeeeerrrr tttthhhheeee ffffoooorrrrmmmmaaaatttt ggggiiiivvvveeeennnn iiiinnnn tttthhhheeee bbbbrrrroooocccchhhhuuuurrrreeee aaaalllloooonnnngggg wwwwiiiitttthhhh tttthhhheeee rrrreeeeqqqquuuuiiiirrrreeeedddd rrrreeeeggggiiiissssttttrrrraaaattttiiiioooonnnn ffffeeeeeeee.... FFFFeeeeeeee sssshhhhoooouuuulllldddd bbbbeeee ppppaaaaiiiidddd aaaassss ccccrrrroooosssssssseeeedddd DDDDDDDD ddddrrrraaaawwwwnnnn iiiinnnn ffffaaaavvvvoooouuuurrrr ooooffff

“INTERNATIONAL CONFERENCE ON BIOTECHNOLOGY– 2011, NIT CALICUT” Payable at Calicut. Payable at Calicut. Payable at Calicut. Payable at Calicut.

ACCOMADATION AAAAccccccccoooommmmmmmmooooddddaaaattttiiiioooonnnn dddduuuurrrriiiinnnngggg tttthhhheeee ppppeeeerrrriiiioooodddd ooooffff ccccoooonnnnffffeeeerrrreeeennnncccceeee ffffoooorrrr tttthhhheeee ddddeeeelllleeeeggggaaaatttteeeessss wwwwiiiillllllll bbbbeeee aaaarrrr----rrrraaaannnnggggeeeedddd oooonnnn rrrreeeeqqqquuuueeeesssstttt aaaannnndddd oooonnnn ppppaaaayyyymmmmeeeennnntttt bbbbaaaassssiiiissss.... PPPPrrrriiiioooorrrr ccccoooommmmmmmmuuuunnnniiiiccccaaaattttiiiioooonnnn ttttoooo tttthhhheeee oooorrrrggggaaaannnniiiizzzziiiinnnngggg ccccoooommmm----mittee is needed to get accommodation.mittee is needed to get accommodation.mittee is needed to get accommodation.mittee is needed to get accommodation. ACCOMMODATION CONTACT

The delegates can also do direct booking in the following hotelsThe delegates can also do direct booking in the following hotelsThe delegates can also do direct booking in the following hotelsThe delegates can also do direct booking in the following hotels Hotel Hotel Hotel Hotel MalabarMalabarMalabarMalabar Palace, Palace, Palace, Palace, [email protected]; +91+91+91+91----444499995555----2721515272151527215152721515

Hotel Hyson Heritage, Hotel Hyson Heritage, Hotel Hyson Heritage, Hotel Hyson Heritage, [email protected]; ; ; ; +91+91+91+91----495495495495----2766423276642327664232766423

Gateway Hotel, Gateway Hotel, Gateway Hotel, Gateway Hotel, [email protected]; ; ; ; +91+91+91+91----495495495495----6613000661300066130006613000

NOTENOTENOTENOTE ****FFFFoooorrrr aaaaccccaaaaddddeeeemmmmiiiicccc ssssttttuuuuddddeeeennnnttttssss aaaaccccccccoooommmmmmmmooooddddaaaattttiiiioooonnnn wwwwiiiillllllll bbbbeeee aaaarrrrrrrraaaannnnggggeeeedddd iiiinnnn hhhhoooosssstttteeeellllssss oooonnnn ppppaaaayyyymmmmeeeennnntttt bbbbaaaassssiiiissss

****FFFFoooorrrr ssssttttaaaaffffffff aaaannnndddd ddddeeeelllleeeeccccaaaatttteeeessss aaaaccccccccoooommmmmmmmooooddddaaaattttiiiioooonnnn wwwwiiiillllllll bbbbeeee aaaarrrrrrrraaaannnnggggeeeedddd iiiinnnn gggguuuueeeesssstttt hhhhoooouuuusssseeee oooonnnn ppppaaaayyyymmmmeeeennnntttt bbbbaaaassssiiiissss

GUIDELINES FOR SUBMISSION The abstract should be prepared in MSThe abstract should be prepared in MSThe abstract should be prepared in MSThe abstract should be prepared in MS----WWWWoooorrrrdddd uuuussssiiiinnnngggg TTTThhhheeee ffffoooorrrrmmmmaaaatttt ggggiiiivvvveeeennnn bbbbeeeelllloooowwww

and a soft copy of the same should be sent to and a soft copy of the same should be sent to and a soft copy of the same should be sent to and a soft copy of the same should be sent to [email protected] oooonnnn oooorrrr bbbbeeeeffffoooorrrreeee 1111SSSSTTTT June 2011.June 2011.June 2011.June 2011.

FORMAT Font: Font: Font: Font: Times New RomanTimes New RomanTimes New RomanTimes New Roman Font Size: Font Size: Font Size: Font Size: 12pts12pts12pts12pts Title: Title: Title: Title: Bold, Single spacingBold, Single spacingBold, Single spacingBold, Single spacing Authors: Authors: Authors: Authors: FFFFiiiirrrrsssstttt nnnnaaaammmmeeee ffffoooolllllllloooowwwweeeedddd bbbbyyyy llllaaaasssstttt nnnnaaaammmmeeee ,,,, nnnnaaaammmmeeee ooooffff tttthhhheeee pppprrrreeeesssseeeennnnttttiiiinnnngggg aaaauuuutttthhhhoooorrrr mmmmuuuusssstttt bbbbeeee underlined.underlined.underlined.underlined. Affiliation: Affiliation: Affiliation: Affiliation: ItalicsItalicsItalicsItalics Text: Text: Text: Text: Within 300 wordsWithin 300 wordsWithin 300 wordsWithin 300 words Alignment: Alignment: Alignment: Alignment: JustifiedJustifiedJustifiedJustified Line spacing: Line spacing: Line spacing: Line spacing: SingleSingleSingleSingle

IMPORTANT DATES

Last date for submission of Abstracts : Last date for submission of Abstracts : Last date for submission of Abstracts : Last date for submission of Abstracts : 1111stststst June 2011June 2011June 2011June 2011 Last date for registration Last date for registration Last date for registration Last date for registration : : : : 15151515th th th th June 2011June 2011June 2011June 2011

NATIONAL INSTITUTE OF TECHNOLOGY CALICUT– 673 601

For ongoing activities, please visit: www.nitc.ac.in/nitc/dept/bio