11th International Conference on

Ultrasonic Biomedical Microscanning

Interlaken InnLakeville, CT, USA

September 23–26, 2018

11th International Conference on Ultrasonic Biomedical Microscanning September 23–26, 2018

Welcome to the 11th International Conference on Ultrasonic Biomedical Microscanning being held at the Interlaken Inn located in the state of Connecticut in the region of the Litchfield Hills. Some might call the area New England and, in fact, the region represents the intangible boundary between Red Sox and Yankees fans. The conference marks the return of the conference to the New York area and also is the first time since 2008 that the conference is in the U.S.A.

The UBM conferences have been running every two years since 1998 with the purpose of bringing together scientists, engineers, students, clinicians, and companies working in the field of high-frequency ultrasound. From the time of the initial conference in 1998, the field has advanced tremendously as can be seen by the program where the focus has shifted from technology to applications.

This year we received 44 oral presentations that have been organized into a program that encourages discussion and social interactions. We have a total of 50 attendees and appreciate everyone’s participation. Every two years, we worry that the field will have advanced so much that the conference will no longer be necessary!

I would like to thank the invited speakers Mary Dickinson, Colin Phoon, and Liang Song for presenting their work at the conference. Direct funding for this conference comes from the registration fees and generous support from a handful of corporate sponsors. We greatly appreciate the support of FUJIFILM VisualSonics, Verasonics, and Mindray, as well as the co-sponsorship of the Acoustical Society of America.

Jeff Ketterling in collaboration with the organizing committee

Mary Dickinson (Baylor College of Medicine)Mary E. Dickinson is an internationally recognized expert in imaging, genetics, bioengineering and vascular biology with over 120 peer-reviewed publications. She received her undergraduate degree from Vanderbilt University where she began her research career in the area of mouse genetics and development. She received a PhD from Columbia University in New York, performing research on the role of Wnt factors in vertebrate development at the Roche Institute for Molecular Biology and Harvard University. She then pursued post-doctoral

training at Caltech, focusing on advanced imaging and bioengineering strategies to define mechanisms related to mouse and zebrafish cardiovascular development. She was recruited to Baylor College of Medicine in 2005 and her work leverages her diverse training. Her work focuses on the development of novel imaging strategies to define the genetic and environmental causes of congenital birth defects and on understanding mechanisms required for vessel and heart development. In addition to the research in her lab, she also serves as the Director of the Optical Imaging and Vital Microscopy Core, as an Executive Member of the Cardiovascular Research Institute, and as a Principal Investigator for the NIH Knockout Mouse Project and the leader of the Embryo Phenotyping Pipeline. Dr. Dickinson holds the Kyle and Josephine Morrow Endowed Chair at BCM and she recently joined the administrative leadership as the Associate Dean of Research.

Colin Phoon (Hassenfeld Children’s Hospital at NYU Langone)Colin Phoon, MPhil, MD, is Associate Professor of Pediatrics at New York University School of Medicine. A pediatric cardiologist whose clinical focus is pediatric and fetal echocardiography, Dr. Phoon got his introduction to ultrasonic biomedical microscanning in Dr. Dan Turnbull’s lab, where he developed expertise in prenatal mouse cardiovascular imaging. Dr. Phoon has been a PI or collaborator on numerous projects relevant to a broad spectrum of cardiovascular disease in small animal models but especially during embryonic

development. For the past 9 years, Dr. Phoon has focused on the role of cardiolipin in mitochondrial biology, in close collaboration with Drs. Mindong Ren and Michael Schlame at NYU. His avocations include history of science, amateur radio (callsign AE3A), and lacrosse.

Liang Song (Shenzhen Institutes of Advanced Technology)Liang Song, PhD, is Professor at Shenzhen Institutes of Advanced Technology (SIAT), The Chinese Academy of Sciences (CAS) and founding director of the Shenzhen Key Lab for Molecular Imaging. Prior to joining SIAT, he studied at Washington University, St. Louis and received his Ph.D. in Biomedical Engineering. He has authored >60 peer-reviewed journal articles, serves on the editorial board of Photoacoustics and is a regular reviewer for >20 peer-reviewed journals. He has invented and developed multiple novel

photoacoustic imaging technologies and been awarded >10 US and Chinese invention patents, including: (1) optical-resolution intravascular photoacoustic endomicroscopy aiming for the identification of vulnerable plaques; (2) fully integrated photoacoustic/two-photon microscopy that can potentially open up new avenues for multi-contrast sub-cellular biomedical imaging; (3) handheld, real-time photoacoustic imaging system for cancer theranostics. His research on photoacoustics has been supported by the NSFC (including the National Key Instrumentation R&D Grant and National Excellent Young Scholar Award), the MOST of China, the local governments, and the industry.

FOREWORD INVITED SPEAKERS

PROGRAM SUMMARY

14:00 Bus leaves from New York City 16:30–17:30 Arrival and Check-in at Interlaken Inn 17:30–18:30 Welcome Reception 18:30–19:15 Welcome & Keynote Address 19:30–20:30 Dinner 20:30–22:30 Social

08:00–09:00 Breakfast 09:00–10:30 Session I: Small and Big Animals 10:30–11:00 Coffee Break 11:00–12:15 Session 2: Blood Flow in Mice 12:15 Group Photo 12:15–13:30 Lunch 13:30–16:30 Free Time 16:30–17:45 Session 3: Contrast Agents 17:45–19:00 Free Time 19:00–20:30 Dinner 20:30–22:30 Social

07:30–08:25 Breakfast 08:25–09:55 Session 4: Photoacoustics I 09:55–10:25 Coffee Break 10:25–10:55 Session 5: Photoacoustics II 11:00–12:00 Session 6: Elastography 12:00–13:30 Lunch 13:30–14:45 Session 7: Quantitative Ultrasound I 14:45–15:15 Break 15:15–16:15 Session 8: Quantitative Ultrasound II 16:15–17:00 Panel: What’s Next? 18:00–20:30 Dinner/Entertainment 20:30–22:30 Social

08:00–09:00 Breakfast 09:00–10:00 Session 9: Transducers and Systems 10:00–10:30 Coffee Break 10:30–11:15 Session 10: Transducers and Phantom 11:25–11:45 UBM2020 Presentation/Closing Remarks 12:00–13:00 Lunch 13:30 Bus Departs to New York City 16:00 Arrival in New York City

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11th International Conference on Ultrasonic Biomedical Microscanning September 23–26, 2018

SCHEDULE

12:00 Lindsay Cahill (The Hospital for Sick Children, Canada): Ultrasound Detection of Abnormal Cerebrovascular Morphology in a Mouse Model of Sickle Cell D on Wave Reflection

12:15 Group Photo 12:15–13:30 Lunch 13:30–16:30 Free Time 16:30–17:45 Session 3: Contrast Agents (Chair: Ronald Silverman) 16:30 F. Stuart Foster (University of Toronto/Sunnybrook Research Institute,

Canada): Acoustic Protein Nanostructures: Preparation, Physics, and Applications

16:45 Daniel P. Sawyer (Caltech, USA): Nonlinear X-wave Ultrasound Imaging of Acoustic Biomolecules

17:00 Matthew Bruce (University of Washington, USA): High-frequency Nonlinear Doppler Ultrasound with Microbubbles

17:15 Isabel Newsome (University of North Carolina at Chapel Hill, USA): First In Vitro and In Vivo Implementation of Acoustic Angiography with Dual-frequency Array Transducers

17:30 Jing Yang (University of Toronto/Sunnybrook Research Institute): Beamforming and Imaging Approaches for Array-based Dual-frequency Acoustic Angiography

17:45–19:00 Free Time 19:00–20:30 Dinner 20:30–22:30 Social

TUESDAY 07:30–08:25 Breakfast 08:25–09:55 Session 4: Photoacoustics I (Chair: F. Stuart Foster) 08:25 Liang Song (Shenzhen Institutes of Advanced Technology, CAS, China):

Photoacoustic Imaging: Technology Development Towards Translations 08:55 Srivalleesha Mallidi (Harvard Medical School, USA):

Monitoring Treatment Response with Ultrasound and Photoacoustic Imaging

09:10 Chengbo Liu (Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, China): Multi-scale Photoacoustic Microscopy: Faster, Deeper, and Fully Integrated

09:25 John Hossack (University of Virginia, USA): Reveberation Reduction in Photoacoustic Imaging using Dictionary Learning

09:40 Felipe Roa (University of Toronto/Sunnybrook Research Institute, Canada): Targeted Organic Contrast Agents for PAI-guided Endoscopic Mucosal Resection of Esophageal Cancer

SUNDAY 14:00 Bus leaves from Port Authority Bus Terminal, NYC 16:30–17:30 Arrival and Check-in at Interlaken Inn 17:30–18:30 Welcome Reception 18:30–19:15 Welcome & Keynote Address (Chair: Jeff Ketterling) Mary Dickinson (Baylor College of Medicine, USA):

Imaging the Phentoypes of Essential Genes

19:30–20:30 Dinner 20:30–22:30 Social

MONDAY 08:00–09:00 Breakfast 09:00–10:30 Session I: Small and Big Animals (Chair: Guy Cloutier) 09:00 Orlando Aristizabal (Skirball Institute, USA):

In Utero, High-throughput Phenotyping of Mouse Embryos 09:15 Daniel Turnbull (New York University School of Medicine, USA):

HFU vs MRI for In Utero Imaging of Mouse Embryos 09:30 James Lacefield (Western University School of Biomedical

Engineering, Canada): Patient-specific Assessment of Anti-angiogenic Sensitivity Using the PDX-Ovo Assay

09:45 Mahsa Bataghva (The University of Western Ontario, Canada): Evaluation of Response to Nivolumab in a Patient-Derived Xenograft Model of Renal Cell Carcinoma Using High-frequency Ultrasound Imaging

10:00 João Carlos Machado (Federal University of Rio de Janeiro, Brazil): 3D-endoluminal Micro-ultrasound Imaging of Mouse Colon Tumor

10:15 Christine Demore (University of Toronto/Sunnybrook Research Institute, Canada): In Vivo Visualisation of Nerve Trauma during Regional Anaesthesia

10:30–11:00 Coffee Break 11:00–12:15 Session 2: Blood Flow in Mice (Chair: Daniel Turnbull) 11:00 Colin Phoon (Hassenfeld Children’s Hospital at NYU Langone, USA):

Two Decades of High-frequency Ultrasound Mouse Cardiovascular Imaging 11:30 Chih-Chung Huang (National Cheng Kung University, Taiwan):

40 MHz Ultrafast Ultrasound Imaging for Blood Flow Mapping in Brain 11:45 Jeff Ketterling (F. L. Lizzi Center for Biomedical Engineering, Riverside

Research, USA): Vector-flow Imaging of Blood Flow in Mouse Hearts

INVITED SPEAKER

INVITED SPEAKER

INVITED SPEAKER

11th International Conference on Ultrasonic Biomedical Microscanning September 23–26, 2018

16:15–17:15 Panel: What’s Next? (Chair: Ton van der Steen) 18:00–20:30 Dinner/Entertainment 20:30–22:30 Social

WEDNESDAY08:00–09:00 Breakfast 09:00–10:00 Session 9: Transducers and Systems (Chair: Carmel Moran) 09:00 Ton van der Steen (Thorax Centre Erasmusm MC, Netherlands):

Looking Forward to Minimal Invasive Ultrasound 09:15 Natasha Alves-Kotzev (University of Toronto/Sunnybrook Research

Institute, Canada): A Hybrid Intravascular Ultrasound and Optical Coherence Tomography Imaging System

09:30 Marc Lethiecq (Tours University, France): Overview and Recent Developments of Piezoelectric Thick Films for UBM Transducer Applications

09:45 Khaled Younes (University of Montreal Hospital Research Center, Canada): High-frequency Capacitive Micro-machined Ultrasonic Transducer CMUT

10:00–10:30 Coffee Break 10:30–11:15 Session 10: Transducers and Phantom (Chair: Marc Lethiecq) 10:30 Paul Harris (Callaghan Innovation, New Zealand):

Transducers for Drug Delivery 10:45 Dave Hughes (Novosound Ltd, UK):

Novosound: High-frequency Focused Probes for Biomedical Scanning 11:00 Carmel Moran (University of Edinburgh, UK):

Development of Tissue-mimicking Materials for High-frequency Applications

11:25–11:35 UBM2020 Presentation11:35–11:45 Final Remarks 12:00–13:00 Lunch 13:30 Bus Departs to New York City 16:00 Arrival in New York City

09:55–10:25 Coffee Break 10:25–10:55 Session 5: Photoacoustics II (Chair: F. Stuart Foster) 10:25 Nidhi Singh (University of Toronto, Canada):

Photoacoustic Imaging for Monitoring Photothermal Therapy in the Prostate 10:40 Andrew Needles (FujiFilm VisualSonics, Inc., Canada):

Latest Developments in High-frequency Ultrasound and Photoacoustic Imaging

11:00–12:00 Session 6: Elastography (Chair: Chris de Korte) 11:00 Guy Cloutier (Laboratory of Biorheology and Medical Ultrasonics, Canada):

Cell Quake Elasticity Imaging 11:15 Marvin Doyley (University of Rochester, USA):

Using Shear Wave Elastography to Monitor Targeted Therapy of Pancreatic Cancer

11:30 Jun Liu (Ohio State University, USA): Strain Mapping in Ocular Tissue using High-frequency Ultrasound

11:45 Paul Kemper (Columbia University, USA): Pulse Wave Imaging for Monitoring Non-linear Material Behavior in an Ang-II Induced Hypertensive Mice Model

12:00–13:30 Lunch 13:30–14:45 Session 7: Quantitative Ultrasound I (Chair: Yoshifumi Saijo) 13:30 Ronald Silverman (Columbia Univesity Medical Center, USA):

Pressure-dependent Scleral Backscatter at 100 MHz 13:45 Jonathan Mamou (F. L. Lizzi Center for Biomedical Engineering,

Riverside Research, USA): Investigation of Microstructural Changes in Myopic Guinea Pig Sclera using 80-MHz Quantitative Ultrasound

14:00 William D. O’Brien, Jr. (University of Illinois at Urbana-Champaign, USA): Quantitative Ultrasound and Early Detection Capability

14:15 Aiguo Han (University of Illinois at Urbana-Champaign, USA): Ultrasonic Backscatter and Spatial Distribution of the Scatterers for Tissue Characterization

14:30 Takuya Ogawa (Chiba University, Japan): Multi-scale Speed-of-sound Analysis in Wide Area

14:45–15:15 Break 15:15–16:15 Session 8: Quantitative Ultrasound II (Chair: William O’Brien) 15:15 Yoshifumi Saijo (Tohoku University, Japan):

Moisture and Acoustic Impedance of Skin Surface 15:30 Kazuyo Ito (Chiba University, Japan):

Chirp-encoded Excitation for Acoustic Microscopy at Ultra High-frequency 15:45 Boris Chayer (University of Montreal Hospital Research Center, Canada):

Pilot Clinical Study of Quantitative Ultrasound Spectroscopy Measurements of Erythrocyte Aggregation within Superficial Veins

16:00 Kazuki Tamura (Chiba University, Japan): Structure Factor Model-based Approach for Analyzing Two-dimensional Impedance Map

SCHEDULE

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The organizing committee of the 11th International Conference on Ultrasonic Biomedical Microscanning would like to thank all our sponsors. Their support has been invaluable to the success of this conference from the beginning.