International Reference International Reference laboratory and Collaborating laboratory and Collaborating

Centers Networks: Centers Networks: Challenges and BenefitsChallenges and Benefits

Vincenzo CaporaleVincenzo Caporale22ndnd Global Conference Global Conference

of OIE Reference Laboratories of OIE Reference Laboratories and Collaborating Centresand Collaborating Centres

22 June 201022 June 2010ParisParis

ContentsContents

Reference materialsReference materials

Laboratory quality, bioLaboratory quality, bio--safety and biosafety and bio--securitysecurity

Definition of a networkDefinition of a network

Networking and working togetherNetworking and working together

Laboratory based surveillance networksLaboratory based surveillance networks

OIE twinning as a tool for capacity OIE twinning as a tool for capacity buildingbuilding

Definition of network*Definition of network*

A system connected by communications linesA system connected by communications lines

* Merriam* Merriam--WebsterWebster’’s dictionarys dictionary

An interconnected group or association of An interconnected group or association of personspersons

No formal procedure for the creation and No formal procedure for the creation and management of OIE Reference Laboratory/ management of OIE Reference Laboratory/ Collaborating center networksCollaborating center networks

Why OIE networksWhy OIE networks

Networking has Networking has an added value per se for an added value per se for all participantsall participants as it makes it possible to as it makes it possible to tap on peer level competence and tap on peer level competence and resourcesresources

Worldwide problems = worldwide response Worldwide problems = worldwide response capabilitiescapabilities

Build trust working together and sharing Build trust working together and sharing resourcesresources

Create consensus on standards based on Create consensus on standards based on scientific principlesscientific principles

NETWORKING AND WORK TOGETHERNETWORKING AND WORK TOGETHER

OIE Network main OIE Network main ObjectivesObjectives

To develop the cultureTo develop the cultureof inclusiveness of inclusiveness vs. the culture of exclusion & vs. the culture of exclusion & supremacy supremacy (the bad example of some (the bad example of some networking )networking )of knowledge sharing of knowledge sharing vs. the culture of vs. the culture of knowledge ownership knowledge ownership a cohesive architecture a cohesive architecture based human and based human and institutional interconnectivity vs. institutional interconnectivity vs. ANY ANY hierarchical organizationhierarchical organization

Exchange dataExchange data

Generate information and knowledge based on high Generate information and knowledge based on high scientific standards and consensusscientific standards and consensus

Exchange of reference & diagnostic material, Exchange of reference & diagnostic material, strain, sera, etc.strain, sera, etc.

Organize interOrganize inter--laboratory testing as laboratory testing as required by OIE & ISO/IEC 17025required by OIE & ISO/IEC 17025

Develop common researchDevelop common research

Develop and validate methods Develop and validate methods and standardsand standards

OIE Network main OIE Network main ObjectivesObjectives

OIE Networking OIE Networking

A core of OIE Reference Laboratories and Collaborating A core of OIE Reference Laboratories and Collaborating Centres working in a coherent way Centres working in a coherent way strictlystrictly within OIE within OIE framework framework

The Core should expand to include other National The Core should expand to include other National Reference Laboratories as well as relevant National Reference Laboratories as well as relevant National Reference Centers (i.e.: epidemiology centers) to Reference Centers (i.e.: epidemiology centers) to create a worldwide net of create a worldwide net of ““strongholdsstrongholds”” to be used to be used strategically for animal diseases and zoonosis strategically for animal diseases and zoonosis surveillance and controlsurveillance and control

The aim and the Term Of Reference of the network The aim and the Term Of Reference of the network must be clearly defined as well as its responsibility of must be clearly defined as well as its responsibility of fulfilling OIE mission and principlesfulfilling OIE mission and principles

OIE Networking OIE Networking

Liaise Liaise throughthrough OIE with other world wide OIE with other world wide and regional network (i.e.: FAO, WHO, etc.)and regional network (i.e.: FAO, WHO, etc.)

Governing bodiesGoverning bodiesRelevant OIE CommissionsRelevant OIE CommissionsA steering committee A steering committee A secretariat in one of the OIE RC or A secretariat in one of the OIE RC or CCCC

Meetings as well as eMeetings as well as e--technology should technology should assure assure effective communicationeffective communication as well as as well as ttransparencyransparency of action and of action and accountability accountability to all to all members as well as to the OIE members as well as to the OIE

OIE Twinning as a tool for OIE Twinning as a tool for capacity buildingcapacity building

OIE Twinning as a tool for OIE Twinning as a tool for capacity buildingcapacity building

ShareShare knowledgeknowledge

Build up skillsBuild up skills

Development & validation of diagnostic Development & validation of diagnostic tests tests ““fit for purposefit for purpose””

Technically & economicallyTechnically & economically

Development of control tools Development of control tools ““fit for fit for purposepurpose””

Technically & economicallyTechnically & economically

REFERENCE MATERIALSREFERENCE MATERIALS

Reference materialsReference materials

The availability of standard reagent is essential The availability of standard reagent is essential both for diagnostic testing, laboratory quality both for diagnostic testing, laboratory quality assurance and vaccine testingassurance and vaccine testing

Reference material (i.e.: sera, antigens and Reference material (i.e.: sera, antigens and standard strains) should be validated jointly standard strains) should be validated jointly and made available by the OIEand made available by the OIE--Reference Reference Laboratories for the various diseases. Laboratories for the various diseases. Networking could be a key issue in this Networking could be a key issue in this endeavor.endeavor.

A catalogue of these materials should be A catalogue of these materials should be compiledcompiled

LABORATORY QUALITYLABORATORY QUALITYBIOBIO--SAFETY AND BIOSAFETY AND BIO--SECURITYSECURITY

The The ““significancesignificance”” of OIE quality standard of OIE quality standard should be clarified as to avoid the idea of should be clarified as to avoid the idea of the existence of two international standard the existence of two international standard on laboratory quality assuranceon laboratory quality assurance

Laboratory quality, bioLaboratory quality, bio--safety safety and bioand bio--securitysecurity

The need to integrate the bioThe need to integrate the bio--safety and safety and biobio--security Chapters to the Quality security Chapters to the Quality assurance Chapters assurance Chapters 1.1.2 and 1.1.31.1.2 and 1.1.3

The need of making clear that accreditation The need of making clear that accreditation of the OIEof the OIE--Reference laboratory to quality Reference laboratory to quality standard is a standard is a requirementrequirement

Laboratory quality, bioLaboratory quality, bio--safety safety and bioand bio--securitysecurity

The need of organizing interThe need of organizing inter--laboratory laboratory proficiency testing for the OIEproficiency testing for the OIE--Reference Reference laboratories should be evaluatedlaboratories should be evaluated

The need for OIE training program on The need for OIE training program on laboratory quality, biosafety and biosecuritylaboratory quality, biosafety and biosecurity

The need to strengthen the laboratory The need to strengthen the laboratory component in the PVS evaluationcomponent in the PVS evaluation

LABORATORY BASED LABORATORY BASED SURVEILLANCE SURVEILLANCE

NETWORKSNETWORKS

Develop laboratory based OIE Develop laboratory based OIE surveillance networkssurveillance networks

Develop a truly international culture and methods Develop a truly international culture and methods on animal diseases on animal diseases [and zoonosis][and zoonosis] surveillance surveillance and controland control

Disease specificDisease specific

CostCost--efficient and effective laboratory based efficient and effective laboratory based surveillance as well as help sustain the laboratory surveillance as well as help sustain the laboratory Surveillance standardSurveillance standard

Information on the Information on the ““eventevent”” besides the besides the identification of agentsidentification of agents

Provide vital and supplementary information to Provide vital and supplementary information to OIE World Animal Health Information System OIE World Animal Health Information System (WAHIS)(WAHIS)

Provide technology and scientific knowledge Provide technology and scientific knowledge

OIEOIE--APPROVED INTERNATIONAL STANDARD SERAAPPROVED INTERNATIONAL STANDARD SERA

African horse sicknessAfrican horse sicknessAujeszky's diseaseAujeszky's diseaseContagious bovine pleuropneumoniaContagious bovine pleuropneumoniaEquine infectious anemia Equine infectious anemia Bluetongue Bluetongue Bovine brucellosis Bovine brucellosis Brucella abortus Brucella abortus AntiAnti--brucella melitensis (ISaBmS)brucella melitensis (ISaBmS)Brucella ovisBrucella ovisClassical swine feverClassical swine feverEnzootic bovine leukosis Enzootic bovine leukosis Enzootic bovine leukosisEnzootic bovine leukosisEquine influenzaEquine influenzaEquine InfluenzaEquine Influenza

Equine viral arteritisEquine viral arteritis

ELISA ELISA ELISA, Virus neutralization ELISA, Virus neutralization CFT , Indirect & Competitive ELISACFT , Indirect & Competitive ELISAAGDTAGDTELISAELISAELISA, RBTELISA, RBTCFT, RBTCFT, RBTCompetitive ELISACompetitive ELISACFTCFTVirus neutralizationVirus neutralizationAGDTAGDTELISAELISAHI, Single Radial HaemolisisHI, Single Radial HaemolisisAntigens antisera for in vitro Antigens antisera for in vitro standardization of vaccines standardization of vaccines Virus neutralizationVirus neutralization

OIEOIE--APPROVED INTERNATIONAL STANDARD SERAAPPROVED INTERNATIONAL STANDARD SERA

Peste des petits ruminantsPeste des petits ruminantsRabiesRabiesRinderpestRinderpest

ELISA ELISA Fluorescent antibody virus neutralisationFluorescent antibody virus neutralisationELISA, Virus neutralization ELISA, Virus neutralization