ST. ANNE‘S UNIVERSITY HOSPITAL BRNOINTERNATIONAL CLINICAL RESEARCH CENTER

RESEARCH GROUP

Interventional Cardiac Electrophysiology

PRINCIPAL INVESTIGATOR

KEY INTERESTSCardiac Electrophysiology • Cardiac Arrhythmia • Stem Cells Therapy • Epicardial Pacing • Ablation • Defibrillation • Electroporation • Apoptosis • In-vitro models

RESEARCH OBJECTIVES Development of new catheters and devices for interventional treatment of cardiac and brain diseases.

Clinical research of catheter navigation, 3D imaging of heart structures and image integration during catheter ablations of cardiac arrhythmias.

Translational focus on stem cell-derived cardiomyocytes and regeneration strategies.

RESEARCH FOCUSThe Interventional Cardiac Electrophysiology Research Group (ICE) is focused on clinical research of catheter navigation, 3D imaging of heart structures and image integration during catheter ablations of cardiac arrhythmias. The main aim is prototype catheter testing and development in animal models, based on the collaboration with researchers from the Mayo Clinic, USA. The ICE is further focused on development of catheters for epicardial stimulation, defibrillation and ablation towards chronic experiments and new catheters with direct visualization of ablated tissue. The further area are regenerative strategies of bradyarrhythmias using stem cell technologies and novel ablation modalities. There is ongoing brain vasculature research with neurologist and neurosurgeons. The magnetic navigated micro-catheter is utilized for endovascular mapping of deep brain structures in animal models, in order to help patients with epilepsy and to improve quality of brain structures mapping. The ICE Research Group is also running research on microRNA in atrial fibrillation.

MUDr. Zdeněk STÁREK, Ph.D.

E-mail: zdenek.starek@fnusa.czPhone: (+420) 543 182 189

CREATING THE FUTURE OF MEDICINE

EDUCATION

2005: Ph.D. in Cardiology, Masaryk University, Brno, Czech Republic

1994: MUDr./MD in Cardiology, Masaryk University, Brno, Czech Republic

TRAINING

2003: Fellow, Cardiac Electrophysiology, Onze-Lieve-Vrouwziekenhuis, OLV Hospital, Aalst, Belgium

CLINICAL RESEARCH CORE FACILITIESBASIC RESEARCHTRANSLATIONAL RESEARCH

TOP PUBLICATIONS

TECHNOLOGICAL EQUIPMENT STEREOTAXIS EPOCH™ – two unites of magnetic catheter navigation system – for humans (clinical research) and for animals (preclinical research).

EnSite Velocity a Carto 3 – 3D electroanatomical mapping system. Catheter Ablation Systems – radiofrequency ablation, cryoablation, laser ablation. Implantation room with full electrophysiological equipment. Fully equipped electrophysiological laboratory with novel technologies.

MAIN PARTNERS AND COLLABORATING INSTITUTIONS Mayo Clinic, Rochester, MN, USA Medical University of Silesia, Katowice, Poland Herzzentrum Leipzig, Leipzig, Germany

OFFERED SERVICES AND EXPERTISE Catheter testing both in human and in animal models. Technical assistance on animal studies involving imaging and electrophysiology equipment.

Human electrophysiology clinical evaluation. Registry setup.

BEST RESULTS Multi-electrode Epicardial Pacing – Systems and methods for epicardial pacing using a percutaneously delivered bifurcated pacing lead that has multiple electrodes that are directionally insulated to prevent extracardiac stimulation, including prevention of phrenic stimulation. In addition, the devices, systems, and methods can be used for ablation, defibrillation, and/or defibrillation in combination with pacing. Invention is covered by US and PCT patent application.

MELUZÍN, J., STÁREK, Z., KULÍK, T., JEŽ, J., LEHAR, F., WOLF, J., DUŠEK, L., LEINVEBER, P., NOVÁK, M. Prevalence and Predictors of Early Heart Failure with Preserved Ejection Fraction in Patients with Paroxysmal Atrial Fibrillation. Journal of Cardiac Failure. 2017.

KILLU, A., NAKSUK, N., STÁREK, Z., DESIMONE, C., SYED, F., GABA, P., WOLF, J., LEHAR, F., PEŠL, M., LEINVEBER, P., CRHA, M., LADEWIG, D., POWERS, J., SUDDENDORF, S., HODGE, D., SATAM, G., NOVÁK, M., KARA, T., BRUCE, C., FRIEDMAN, P., ASIRVATHAM, S. A Novel Defibrillation Tool: Percutaneously Delivered, Partially Insulated Epicardial Defibrillation. JACC: Clinical Electrophysiology. 2017.

PESL M, PRIBYL J, ACIMOVIC I, VILOTIC A, JELINKOVA S, SALYKIN A, LACAMPAGNE A, DVORAK P, MELI AC, SKLADAL P, ROTREKL V. Atomic force microscopy combined with human pluripotent stem cell derived cardiomyocytes for biomechanical sensing. Biosens Bioelectron. 2016, 28 (85), 751-757.

STÁREK, Z., LEHAR, F., JEŽ, J., ŠČUREK, M., WOLF, J., KULÍK, T., ŽBÁNKOVÁ, A., NOVÁK, M. Three-dimensional rotational angiography of the left atrium and the oesophagus: the short-term mobility of the oesophagus and the stability of the fused three-dimensional model of the left atrium and the oesophagus during catheter ablation for atrial fibrillation. Europace. 2017

NEUZIL, P., ORMISTON, J., BRINTON, T., STÁREK, Z., ESLER, M., DAWOOD, O., ANDERSON, T., GERTNER, M., WHITBOURNE, R., SCHMIEDER, R. Externally Delivered Focused Ultrasound for Renal Denervation. JACC-Cardiovascular Interventions. 2016, 9(12), 1292-1299.

St. Anne‘s University Hospital BrnoInternational Clinical Research Center

Pekařská 53, 656 91 Brno | Czech Republic | ID: 00159816Phone: (+420) 543 181 111 | E-mail: icrc@fnusa.cz | www.fnusa-icrc.org

Supported by the project no. LQ1605 Translational Medicine from the National Program of Sustainability II (MEYS CR)

CLINICAL RESEARCHDevelopment of Novel Strategies for Early Diagnostic and Advanced Treatment of Neurological Disorders, Cardiovascular and Oncological Diseases