Intra Uterine Insemination -

IUI

What Is IUI?

Procedure to treat infertility by:

Ovaries Stimulated to produce more eggs

Seminal fluid washed in artificial media and introduced into the uterus

Sperms swims towards the egg for fertilization to take place

Entire procedure takes 15-20 minutes

Indications of Intra Uterine Insemination

1. Infertility Due to Abnormal Semen Can be either due to abnormal sperm shape, motility and viability. IUI helps to separate the normal sperms from abnormal sperms thus achieving fertilization.

2. Cervical Factors:Abnormal position of the cervix

preventing sperm travel to the egg.Thick cervical secretion during ovulation thus preventing sperm ascent to the uterus and to the egg.

3. Ovulation Problems

4. Semen Allergy:Some woman are allergic to the protein in

the semen of their husband which causes discomfort after intercourse so most couple prevent intercourse thus preventing pregnancy.

5. Unexplained Infertility:There are many unexplained reasons for

infertility for which the only treatment solution is IUI.

6. Antisperm Antibodies7. Erection and Ejaculation disorder8. Mild Endometriosis

The cases in which Intra Uterine Insemination is ineffectiveBlocked or damaged

fallopian tubes.

Ovarian failure.

Severe seminal fluid abnormality

Severe endometriosis

Preparation for Intra Uterine Insemination - Artificial Insemination

Monitoring

Ovulation 

• Monitoring of ovulation is done by vaginal ultrasound after the woman is given ovarian stimulating drugs to make sure of the maturity of the follicles

• Doctor usually prefers having at least 1-3 mature follicles to give the HCG injection

Preparation of the semen

sample

• After 2-5 days of abstinence semen collected in hospital

• Normal sperm isolated from abnormal sperms

• Sperm separated form other components and concentrated in a media.

• Total time for sperm preparation 30-60 minutes.

Intra Uterine Insemination Procedure

Done in the clinic of the doctor, and there is no need for

medication or an

analgesic during the procedure

Speculum is placed in

the vagina and cervical

area is cleaned

Specimen of highly motile

sperm is placed in

the uterine cavity using

a special flexible catheter

Success rate of Intra Uterine Insemination - IUI:

The pregnancy rate of IUI is 10-20% and it depends on the age of the wife, her health situation, and also on the number of motile sperm that is used in each cycle, and the pregnancy rate in 2 IUI cycles using 5 million sperm is more than the pregnancy rate in 1 IUI cycle using 10 million sperm.

For couples of unexplained infertility, trying for 2 years, female age under 35, and normal sperm, the success rate is as follow:10% chance per month using

clomid, and IUI for up to 3 cycles

15-20% chance per month using injection by FSH medication, and IUI for up to 3 cycles.

Risks of Intra Uterine Insemination - IUI Rarely, IUI may cause infection

in the uterus and tubes, from bacterial contamination that originate either from semen sample, or contamination of sterile catheter in the vaginal or cervical area during the procedure. Careful cleaning of the cervix and cautious technique alleviate this and make it a rarity.

Commonly Asked Questions

How many times can the IUI be done?

The IUI is usually done twice during the treatment cycle, and it has been proved that doing the IUI twice increases the pregnancy rate because it decreases the loss of the fertility period during the ovulation, but there was a study that was done comparing the pregnancy rate after IUI on one time, or two times, and found no difference.

After the Intra Uterine Insemination any life style changes is required?

Usually, the IUI procedure takes from 15-20 minutes. The patient is then asked to lie down on her back for a period of time

The patient can continue her normal life, and passage of a small amount of blood in 1-2 days after IUI is normal

When to expect the Intra Uterine Insemination Results?

Pregnancy test should not be done before 2 weeks have past since the IUI. Doing it before this may cause false negative result (which means that the patient is pregnant while the test is negative), and in the cases where hormones are used for ovulation induction, like HCG, doing the pregnancy test before 2 weeks can cause a false positive result (which means that the patient is not pregnant while the test is positive that is caused by the HCG hormone that is found in the blood).

If Intra Uterine Insemination fails, when can it be repeated, and how many times?

 It can be repeated 3-6 times to increase the pregnancy rate

 It can be repeated after at least one month or more, this depends on the doctor's and the couple's mutual decision

If IUI fails after 4 trials, it is preferred not to repeat it. The doctor will decide the next step according to the case

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