Cellular Response to Injury: Intracellular Accumula5ons

Charles L. Hitchcock, MD, PhD Department of Pathology Wexner Medical Center at The Ohio State University

MPPC Objec5ve

Describe the mechanisms of cell injury and dieren5ate among the various mechanisms of cell response to injury.

Specic Objec5ves

List the types of material that can be accumulated within cells and the four major mechanisms of their accumulation.

Compare and contrast the etiologies, the cellular mechanisms, and the morphologic features of intracellular accumulation of:

Lipids in hepatocytes and macrophages Proteins Glycogen in glycogen storage diseases Exogenous and endogenous pigments

Mechanisms of Intracellular Accumula5ons

Accumula5on of Lipids

Triglycerides

Cholesterol

Glycolipids ceramide,

gangliosides, & sphingomyelin

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Any Ques5ons?

Contact me at: Charles.hitchcock@osumc.edu