intracellular production of adrenal renin in the fetal mouse ...t'o~ ",.,,,~ •• , or...

12
Instructions for use Title Intracellular production of adrenal renin in the fetal mouse. An immuno-electron microscopic study Author(s) Kon, Yasuhiro; Hashimoto, Yoshiharu; Kitagawa, Hiroshi; Makoto, Sugimura; Kazuo, Murakami Citation JOURNAL OF ANATOMY, 176: 23-33 Issue Date 1991 Doc URL http://hdl.handle.net/2115/5510 Rights Copyright © 1991 Cambridge University Press Type article Additional Information There are other files related to this item in HUSCAP. Check the above URL. File Information JA176.pdf Hokkaido University Collection of Scholarly and Academic Papers : HUSCAP

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Page 1: Intracellular production of adrenal renin in the fetal mouse ...T'O~ ",.,,,~ •• , or "" ..... __ .,...., (RAAS) io ....,.t-.! -. by .iu ..... paaIolai ~ .. "'" bWy. io ..... ""i

Instructions for use

Title Intracellular production of adrenal renin in the fetal mouse. An immuno-electron microscopic study

Author(s) Kon, Yasuhiro; Hashimoto, Yoshiharu; Kitagawa, Hiroshi; Makoto, Sugimura; Kazuo, Murakami

Citation JOURNAL OF ANATOMY, 176: 23-33

Issue Date 1991

Doc URL http://hdl.handle.net/2115/5510

Rights Copyright © 1991 Cambridge University Press

Type article

Additional Information There are other files related to this item in HUSCAP. Check the above URL.

File Information JA176.pdf

Hokkaido University Collection of Scholarly and Academic Papers : HUSCAP

Page 2: Intracellular production of adrenal renin in the fetal mouse ...T'O~ ",.,,,~ •• , or "" ..... __ .,...., (RAAS) io ....,.t-.! -. by .iu ..... paaIolai ~ .. "'" bWy. io ..... ""i

, ....... ,. ,,., ... i>-lJ

....... ,--~--

" Inl ...... llul.lor p<odoc,;"" of ad,,,,,,,1 ~nJn In lhe fetal....,..... An

ImDluno_deClron mlc~kaJ Mud,

VA SU H''' O KON, VOSHIHAR U H AS H'MOTO, H'"0.H' ~ IT .0 0 .0 Vi A ' , ..... KOTO S U (] 1M U II .... lit> " .. lU U ",UII .. " .. M "

I),P"''''''''' of v" ... _ , AM I_y , £"""" qf V" .. _ y M,di<'-, H~*.;';" U. I .. ,JjIY. ~ (l6Q, ' (UI""'''''' qf v""""", A""'_y. fo<o!', of ~'i<WIWf. To"",; U .. ,.,n ly. To" .. ! 630 -.I t v.,.., .... , of Applitd

-..,. U", • ..,i" of'MoN. I_I XI!, , _

(A"""' .... 6 .~._ 19'1O)

'~ .. ODU"T'O~

_ .. " 'ri....,... ",.,,,~ •• , or "" ....... __ .,...., (RAAS) io ....,.t-.! -. by .iu ........... paaIolai ~ .. "'" bWy. io ..... ""i .. o __ ... l)lDpIIo'''~_po e''''''''' ........ r_...." .. __ """ "" .... ," .. ,po..-. _ (0.", . f...,..... . ''176, V"""" It""k<od •• 1 a G.., ... 1978).

I . """., "od;" .• ""., mu~,,"'" ')1t.,. "", t>mo f<p<>rt«t ,. "'" I.ol..,­(N ..... ".r 1m, To.""" '" Ho<'en,""'. 1911 , T._ " 0/, 1931 l. brll. (""-bot. 0 .. ,. 0._ '" Mo.-d. L989, 0.."" ,,01 193! . M<~,nri<. No_ "­I .... mo. IN!). 04=>.I",nd (D<>cI><_" 01 19800, Mi,."", Ho/rm ... M' ~ "";' '" 'no_ 1m. U ..... ~hoob. ~. 11_ •. Im~ .,...,.(1.-,""""","" 0/ 1"11 . r.1ombo ,,0/. 191'J~ 0*1 ..... (PuokyA I ........ 1936: I"Iondcy. M,,.,.,,A I.......,. I .... ) ;., oddr .... '" "'" <IooooO:aI .,...., _!hrOaP>aI "" bod, I. ,II< od«Nl pu.i. port.:lllo<!y. t><eo_.... • ,,-.10 ... "".'._ .... _ ., _." ___ 1 ' .. ~.,.- 1000 t:..oa ~ ill .... ftAAS (D 1 .... A (;0-. 1911~

TOt __ Ioo.",_ .. ",,, t 110 11y .... '''''~ ..... <0. 110 "", ....... __ nly ...... IruI 011 ..... , ",04 _I 0.,.. " ,. II or ... '""''' (K"" .. 0/, ,9'11), ""'"' 11.1"","",0, ~m .... A '-i .roh "., 1991). ... ~.....,h " "", *" ..... "'" rhot ,I>< ,x "I0 .. ,~, ",I P'O<d5 of "",.-«>0"''''''1 ",I ~ i. """,mr»ni<d <10><1, I>,. ad .... 1 ~., ,I>< q"''''''' os to ~II<,"'" """ n i" Ik< r,,,,1 ad .... , ... "";, """,0=1 by ad", .. I .. I~ I ...... "''' . .. ;, , . .. ,,0<1 in,o til< C)'lopia,m (""" , II< .. ,,_lola, nui<l '" _ hoI "'" ,-« *" ,",~" ,"".

t. til< pi'<Oen' """" "" .. '" ,. ,n"pl«! ..... _ .. ,niAI «11< ;" "" 1< .. 1 04 .... 1 ",011 _ <II< _ "·1Oid ~ <cduuo.'" ( Rod. '9U) ODd ... _ .... , ........ pood.....! ODd _0001 ~ 001 ...... """"'" cdb. Ad<Io'-.y. ""'" _ poooibilO;.. """ _ I "" ...... "" __ 1 0/ ..... ""'mool ..... .... , .... ed .

U".'ALS . ~o ,, "~OO. TOt _ or,.." ""'" (fWb/ <) __ do"'" f""" ,110 s.d' .. of. , .... 001 pi .. ,. ,II<

... 0Id f ....... (0.) 0 of pn",''''''} The __ ..... ............... ~i'. ,,"'"" . 0Il kiLLed "" , he 14th, I<><h.od 18,h do, • ., ..... , .... The .0"""" ",nd~ 00~'1 ,.

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Page 3: Intracellular production of adrenal renin in the fetal mouse ...T'O~ ",.,,,~ •• , or "" ..... __ .,...., (RAAS) io ....,.t-.! -. by .iu ..... paaIolai ~ .. "'" bWy. io ..... ""i

y, KOS AND O T H .. '

It.< ,;JO<)'~ wm ~;,><ctN! f= U~OI' "erw-mi<ro>«:>p< "d fUN! ,0 ,n ",-rokl (>l '~ Jlota"ldeh,'<k ,<1<.1 4 ~. 1"""rQ"",ldehy<k m;"o" bWf.«<l ~'I ,!o (>L ~ '''''<>'.1)'10" .oo i"", (pH H) ro.- 2-4 I>ou"_ The " """. ~<'" tben ri....J ",h 01 ~ '''''''')'l>« boff". ",hyd,.!Od ~," ,n <''''001 ",ri<>.oo ""WdeO '". (x'[run,,,d. 1 ",,-,-ti< mod i,,", ,ithe, lR ~'h,« =in (Loodon R.~n Co .• UK.) 0' I.-owk-<,I K.'M "'~" (O><m,,,,' , W" .. low,. Go"".,,), R,.."y, »mp"" ro.- LR "hi" '" low",,.. K4M emi><dd;" "'" doh,d"" od '0 100 % « 0>001 >O~ m61,,.!Od ," "'t" wi,h I : I. 1:1. l, I ,.,1, '" "~,"ol ml>! u",. im ... , k>l '" pO" "~O .0<l6" lIy poiymeri><d ot II 'C to. 2' 00"'.0' " _ lPC r", ::4 1>0"" ,"" ,,,,, at ""'m I"Ope",",< fo' !-4 day,. "'r«,I",Iy. Som< ,I"",, ""'" ti,od i. J % Ilu" .. ldeh,o<, p".!fued i" I Y. """,om t<t,m;J, . O<l emb<dde<i in <P"'Y ""'".

The ol,,..,hi" >«Ii"", "",.iO«l r",m ttic h, 'd",prulie .m!>od<l'" =i" ~~"' <"' ~·i,h. Po,,,,_Blum MT_' ,"''''"0«<><00-.< , ""","«<I 0" "~kd oridu<l<.l d ri<d,,)7 'C, The sect"'"' W<t< tI.<. "",ted ";t " oJ" fo il,,"; . , ,mm ' O<>C1'O<Io<rn"'-' p.-oc«!u", 00 ~"ffin ""'''' '" " ",,"", cc <"",be, B,~ny , ,,,< ,.,,,jo", ~= riOS«l ~' i th phosph. I .. bulr • ..w " """ (pas).O<l ,,,,to" ",to ' % oo,i .... ,um . 'bum;n f", 1 '>-)0) ",,"o"~ T",,,. w," , ho. i",.'"',<>l ~i ,h , ot;. "",." ,ubmanOibulo, ,,,"in ,,~~ ; t

""WIt (I ,3000)" • 'C o.-.""'~t .,,- '" '''''''' "m"",,'u" fo< t~·o 00"", nn,..! wl,o r s s ,h,,,,;m<> . 000 iocuba,«I ",th e<>lloilil told ( Il om). I>l><Ii«! pm"in A """'p ..... {Eo-Y t..brn-.",ri«, loc., USA)" room _I'<"' u", fo; ,h;"y """",....,"' ".,.,_ They,...r< ri""'! ~"h pas ,nO tben ";th ,""ii i«! ..... ,,' an<I 6 .. "y ,,,,oM ";,h .. ' u .. ,," ..,"""' •• ,,"yl "",,,,,.<1<.1 !<ad c;,,,t< , ' he,,- ~'''< "odl«! ";,h. nIT AC~ ' HU·llA ,I«",on ",,,roswr<" 1) . V_

Con,rol ""","" ~<" ,,,,, ",,'00.1 wi,h """",I .. bbl, ,..-urn. PBS", ",..""',bed •• '; .. ,om s.ub<ti"teJ fo< prim.o,y "n""",m The ,is<_ ."'_ in <I''''Y =in ~<'" 0""",«1 ",i • • ,t",;<>< p,oced.,,,,

.. WLT>

I><>y ,. oft''''''''

The G<>1g; 'W''''''' of tb<",rtieol ",U. iOdj""'"' '" ,,,< """'0'1> • ...".«1 0"" 0.- '''-0 ""1I..Je,,k>p<d "'I"'"' ;" ,t>< i""u-ooc~" ,..,.1"0". t.., .. "umb." of ><=<O' Y ",,,1<, <1"w",,, w m"",," I>omo .... o .. ""-,,ri.1 of mOO<oa" ,10<,,,,,, o." , i!1 A"",,","", to ,t>< d;,,,,",,, from 't>< G<>lgj 'PPO'-"u~ """"",' I""U'" w<" Qf va riQU> ""p<>. "''''',, round_ o.al, """"",. 0' ho",,' o<-''''p«i. >Orn<ti,"" ,t><y ;",ludM """" min, ,, VlI<ool<>. "",,'" .,,- ]a"",I>, ,or"" .re>, 0. Da, ,. of " ''',i"". ' h, ",n""'..-", "",'ivdy r.O' i. "omo., ,<1<.1 ,"""un:<! 200-300 run i" di.il_,,,. A "".11 ' '''0'"' 0' ' ''''~ """orl>,mk ",,,olom (ER). ~i'" .., ~il>«<I 'uml", "<"' 0",,"00.1, ,.1><",,, . """"" ER ... , ..,. 0"",,«1 ",-..-hm i" ,I>< <"opIa=

' m",u"""",,,,_,,,,lly. >Om< fO Ol pa,,~Je, """ """",",,,,tod '" ,I>< GoIa; 'PP""'" of ,b< e<>~"",1 celb aO)a«"t tQ t"< """,.", {R, . la). A "", II " " "' ... , of 'r«'Dc I"""'" I>l><Il<d "" kly ",i," ",1<1 pan"", W,," ~I"nbu!o<l '" ,I>< G<>1a;

"o-" ~). ' ''''''''' ____ .......... _~ __ __ .. 0., ,,"' .......... ,.,,....-or, _ , ........... , ... """"' _.~ .. """""'" .... "'. L."" _ . "'>I,"'. ~' A ....... ,.." ... ... _ ~ d,, --" _ .. "" ___ "' ......... 'L •• ~M""" .• """",A"..-_, ..... ",_ ..-_ _ .. ... m, ... "~ ... _ "'" '" _ "'_ .. "'" . ,,"" ..... LOw""' ...... ,"""

Page 4: Intracellular production of adrenal renin in the fetal mouse ...T'O~ ",.,,,~ •• , or "" ..... __ .,...., (RAAS) io ....,.t-.! -. by .iu ..... paaIolai ~ .. "'" bWy. io ..... ""i
Page 5: Intracellular production of adrenal renin in the fetal mouse ...T'O~ ",.,,,~ •• , or "" ..... __ .,...., (RAAS) io ....,.t-.! -. by .iu ..... paaIolai ~ .. "'" bWy. io ..... ""i

y ,ON A~" OTlIU,

",po •• OO bonoo, h ,I>< ",II meml>o" ... , Altoo'Jh 0001,. r"", p"rt;"b ~«, oo..N<O on ,I>< O<:>lso I>mel""', ..,.". ~.,,, lox"," ;n ' h"" ,,,,,,,I,,,, ~';o", ,n.:! in 'h< ".""" .. nub \ Fi$' • b). No ~n_ W<ft ,h<>w. 10 k>CIIh", on , he GoI .. "';"In, ooo.OW ,."id., 0' roo&!> fRo s.-,;""",, <>t""" iI" " <1<:"""" 01' po rt;""'" '"",," ;"" 01' "'0<)''''';' of """''''''i "" ,'Ole> op<ru". ;.'0 ,he ""ocdlul .. <poe" ' .. " """"n" .. M {r;a, I oj.

Day 16 if V>i.,"" The "",,,.1 0<1" ""1><<01 '" th< mOO wl' P=<"""' m",h..,,,, ",, 1I~1op<O

Go~ >1'1""'" (boo [110 .. "" 0.,' .. , They h><l ".Mo", sh,,,,,~ ""'" ",,'~riOj' b"" N,..n<!..,.... d,,""'" ;0(0 ) '" 4 "".Ik, """"'''', A b", """,", of r<>'J~ ER .~, d i"rib",od ,h,_hout to. ')1or'"m, ~ hik • l=' deal of """"'h ICR w" "'" r""nd, NUm<rou, ""''''''Y i"'""~' ""'" ,,-~ ,t=d ju" t><:n""h ,I>< « II mem"' .... ' I><>< """,.f<>l 300 600 run ;n clia,""",

'mm""""to<h<m'<>lly, " ,me," " , ",Id ",,~icln ~= c\<m<)n"",OW in th< Gol,; r<jion a, ~.u OS ;n ,0. Sp«i& ><=<"", v.o-nu~, m" 20), AI[ho",h r .... "" "" t<>Id f"rtic'e> .,'< d<po;i,ed on ,I>< Gol" .,;,!<m,>< th<m"'I"~ tl>< [" ,"m,1 a mpulla< and

Page 6: Intracellular production of adrenal renin in the fetal mouse ...T'O~ ",.,,,~ •• , or "" ..... __ .,...., (RAAS) io ....,.t-.! -. by .iu ..... paaIolai ~ .. "'" bWy. io ..... ""i
Page 7: Intracellular production of adrenal renin in the fetal mouse ...T'O~ ",.,,,~ •• , or "" ..... __ .,...., (RAAS) io ....,.t-.! -. by .iu ..... paaIolai ~ .. "'" bWy. io ..... ""i
Page 8: Intracellular production of adrenal renin in the fetal mouse ...T'O~ ",.,,,~ •• , or "" ..... __ .,...., (RAAS) io ....,.t-.! -. by .iu ..... paaIolai ~ .. "'" bWy. io ..... ""i

i>«'!ov.o " ~.Ioc>.'«1 """ tI." """r 'W'''''' ,,,",_ • "'''',;.", ~ ; lh fOld I"'rtic~, {Fi" l ~ l . 00 fl.) '6 of ",'Ii'iM. 1'" ",,,,,;,,,,,. or "",doc , ,,nub ~'" i",,,,.,ro .. """'PO"'" ~,"~ ,1>00< on lny " wl><"" "'"'" ,,, ou ~,. "'C" '00se ""'iOJ ttot "", .. '''pc .. to< ",,,,," ng it> OU ~'. d..J "'" ",,,,,t , AJU ""'MII,." .~. 00"" ,hot >Om<

"""""I cdl<, in ~ b .. h l"'" po rt",,,, <<><,004 "mtI\1y "''' .".ali< I""."" ~~« "",t<4 J"" l>< ,,,,,t~ 1'" «II m<rnb,.,,,, "", ..,. ron"'"'" " . 11 I" " .. """" '''''''" {Fo" l <)

Do)' IS of g""""'" The GoI~ 'PI"o'''"' of ,'" <""." , " II, ~~, "'"',<<<<I 'h''''',,,,,,, ' I>< C)''''~l.,m.

boo"" "i,i<l<d 1010 • nurn l>:' o f roo<tio"" ~h ;~ GoIiJ ,,,,-,,,,,, ~_ ",I,,,,,,,, "".Ib

'n """be, '0" ,00;< on 0.., I. or ..,.to,ion !FI" ldI, " ""''''«<l q .. o1it)' of ""''" ER w .. de,,,,,,", only"","" , he n""ic"" ~ h;le. toOO ,"", l or ,moooh ER ~' .. 0 '>1"00'«1 'h,,,,,iho"' ttot c)tOJ'h ' ''' , S ... II ",,,,'ory .... oul« .,'" """""" ... ,«1 " ,'" r""" or """oiom«otoo"' ju" be",""h ,'" « II """,boo,,,.. 'mmu""")',,,"'m~,'ly, ,)'~~ I"",~ '"'''''''' r", """. u. """I, doc","""

Soo!<1;""" only. r,w >p«ific I"""'" « ><1«1 ~<>k~', Th<s< "",,," ,,,d 20(HOO 0'"

Page 9: Intracellular production of adrenal renin in the fetal mouse ...T'O~ ",.,,,~ •• , or "" ..... __ .,...., (RAAS) io ....,.t-.! -. by .iu ..... paaIolai ~ .. "'" bWy. io ..... ""i

XI Y.KO~.~I>'"H''' io ~_ ODd __ 10<1 io ............. hm<aoll"'<dI __ boo .. (r ...

Jt~ No ..,... ~ -.. -..... .. "1 ponioao 0( GoIsi oppon, ... l1Itt< __ .-,kK ... " ... ....-.. .. "' ___ .~._'''' ..... 0( ...-_'" .. -. .. _ .. ill _I>« io ___ 1)01 16 0(

_,_(rIC- ,<~

Page 10: Intracellular production of adrenal renin in the fetal mouse ...T'O~ ",.,,,~ •• , or "" ..... __ .,...., (RAAS) io ....,.t-.! -. by .iu ..... paaIolai ~ .. "'" bWy. io ..... ""i

" _"" ... "u'" .... "It ~ ,_, .. , .......... <If ... .. _ ..... <to'" ~)'pt ... ...-. ..o, to. prod""'" lI!' ...... Ea, It~ .. r ....... _"" io "" rr-o' "udr .... ' ,., Golsi ..... Do<.- _ ... ~ .., ....... buo .... _..J __ a.d "" _n .... -.... ._ .. Io<aliu .... of "" ...,

ronde> '"'" "' .......... r-... """"lOb', rOO' "" '"'_"'" _'u ...... of ..........,.. .. ,_ ........... , "'" <leo, .... of. fH_"'~'" r.- "."..... ... , -... "" ' ........ rl<'< ,,1:,'" Gel'; _".,.no'" or .. ,lot _.n.a.., .. ~ .. .. loey (T .. "",. M."hmi " K,m, 1986),

Duo", 0.)'0 16 to 11 0( "" .. ,.,.. b«oul< 0/' II>< l<n<I<ocy f", tho It.in im"""<",",,',i,, both ;, .1>< 001'; ,pr""'"' ' .n<! in lhe ...,«too, .... "'~, to ......... 'M (0110<0'" two ,ypot_ .r<1'fOPOO«I (il Ad .... ' If.in ~ . .... I"".ry .,.."". 0)'., .... 00<1 00', m r .... ' b( . . ... I, "' .... I>t Iiotl>Ct«l .. t.o.q .... ,!y ~th .... i .. m""""' .... ~ ""boo",· "1"'-'> .... .- ... _ .......... ;. ..... , ... .....a. ",." . rt ...... ...".,.,. ohl. <kk "_"'" (DoKh.Wi' .... ,_, "'._. No ... a,_ 19&<~ Tbrt<~"" ........ " ........ "'bt""_bjo .... d6"._ ................ of "" .. 1>-__ , . _)O<U<. """' ...... _

_ nr __ ,bo' """"" _ ............ 10 "- ,r... "'lolCRl ~r 1M..., .... ,,... """"' '' l .. p..,;, 19U,No_"._ ,_; Ul>«b, H"""' .... F...". a Q.oe<ocIa. Im~ Fu ....... "od, .. _ 10 ..... ..-or "'" ......... p.a.d .... in;. 0<1 .... _h ~ he _""' ........ 11« .......... 1 """,_,_ (oi)"" ........ , po ... Pf<'d""" p«>m>in ,h_po.l I"'<" ,nc! """ • .,.J Iif" ,110, ..... un'_" _~ ~.bIt to _,~ t l>< ,...,. .. "',.,,, r_ ".o,..i, ,",I, d.rin, . ""'~ ['<rio<! of r ... , "r., The <",)m< , , " , "" , ' .. ,~" pro·",,,,,,,n' in ,,,. oJ , lO , .. "'" i • • """. ' 0 ... . "" I><p<i. (T .. ..,.... HOM., ~ob>li", 010 Kh'",hk ' ''U~; T •• , ... ""j 1 98H~ " "",n"y, ~ "' .............. till" "" ....... ' R .... ' , """'l*<I;n "ni" .... ul<o of oM oJ,.,..l ,..nO (K .. " .. , ,9\1, ~ M_ ........ ~ ."",ton """'''''' .. wMclo .. , .. , .... ' " .......... ..,.nIod or ..... of ..... ,)'ft''''''''''_ ""'r ,""', .. ....,..... .. .,.n:>d_. ood .. ""' ............ .- .... oM ....... 1 .,; ....... _ (Scale)"" I",*~ f u ..... iD ...... _ ... ..- "" oM "'-;_rof_ XC<b(ItI r_ .. ,....-I .........

...... _"'n. oeIlo "' r"",1 oJ ..... 1 .... ,10 of ,,.. ...,.... ...... ; .... " .. 0001 ."h ,,.. 11<0<"" A-lOkI _"""'l"otkm ... 1 """"'Jilt, On 0., ,. of 1'>'>10',,", • """. " .. mo., of,..,..:ift< Jr' •• '" ~<'" """'kly Immu""""""'" . 00 ..... d;.oi", .... in , lit Golli rq>on, s."...,,, .... , ."",,,,n' <><><)' 011' of .. 1oJ ·lo o.,,,,, PO"""" oo..w t>< _ ""'''nt i.", t l>< ""oc:<lI w.., Opo«, On 0., 16 of ... ",;0;.. "" .... " .... oId ".~"'~ ."" <ltmo."''' .... i. ,I>< Go>ili ",po" .. ...u " ,. ,he ,..,..:iii< _ory ".n."', I~,;,) of tht ..,.rnK ".-... "", ........... _<Cd .... 0I. 0., I', II>ooth _ "' ........... __ '" "" .... ......- .... olo tile .. tiOOdy, On 0.1 II of _ -.._ r"" ...... _,..,. wIoilt • Itw d .. ttftd _._ ..

"" ..... __ ......,... ... ,ed';"" _01. "" cd ............ "" told lJOOf1>d« -. _ .. olot GoIi> ."""" .... """'" ..... pmod ood ..,.. """"Ie> _u .. rOf ,..., ........ _ """' .. o.y 16 of .... __ n.... ... uIu "'""" ""' ....... __ ond _1<'1 ~ t.j odrall_O<aI <d .. ,n ........ r.,.11if< ofU" -

11", worl ..... " ~r>""ooJ 0)' G".,,.,. AOj ror :;o;,n, i& R,1<""k ("Of. 0J.I80090. 6J1l)()lJJ .04 Ol7l'}l lO) from tl>< M,.'"fY of &1<1<011"", So.""" ,00 C"~""' . J.p" ' ,

Page 11: Intracellular production of adrenal renin in the fetal mouse ...T'O~ ",.,,,~ •• , or "" ..... __ .,...., (RAAS) io ....,.t-.! -. by .iu ..... paaIolai ~ .. "'" bWy. io ..... ""i
Page 12: Intracellular production of adrenal renin in the fetal mouse ...T'O~ ",.,,,~ •• , or "" ..... __ .,...., (RAAS) io ....,.t-.! -. by .iu ..... paaIolai ~ .. "'" bWy. io ..... ""i

AibmaI ""'" '" fo'''' _ "

a"'~"", ~ .".ll .... '' ''-''­~ ... , .. ,.-

"""", - ........ ' .--,,,,--