intracranial pressure monitoring in intracranial hypotension · csf pressure values in mm h2o...
TRANSCRIPT
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Intracranial Pressure Monitoring in
Intracranial Hypotension
Dr. Abhay Moghekar, M.B.,B.S.
Johns Hopkins University – School of Medicine
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• Continuous ICP Monitoring Setup
• cICP in skull based CSF leaks
• cICP normative data in upright position
• cICP in spontaneous spinal CSF leaks
• cICP guided percutaneous intervention
• Units: 1 mm Hg = 1.3 cm of Water
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Limitations of measuring opening
pressure during lumbar puncture
• Improper positioning, especially when performed under fluoroscopic guidance
• Diurnal variation, increased pressure with sleep-disordered breathing (apnea or hypopnea)
• Hyperventilation due to anxiety and/or pain lower ICP
• Pressures often normal in lateral decubitus position – not surprising since the majority of leak patients have abnormal pressures only during upright position when they are most symptomatic
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•Direct measurement and graphic recording of intracranial pressure through
a trephined opening was described by LEYDEN in 1866.
•KEY & RETZIUS (1875) were the first to measure CSF pressure in animals,
and KNOLL (1886) produced the first graphic records CSF pressure
•Lumbar puncture as a clinical method introduced by QUINCKE in 1891
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Then…
Bedside continuous CSF pressure monitoring
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and
now…
Heart rate, EKG, respirations, and oxygen saturation are recorded in addition to CSFP referenced to the external auditory meatus. Signals are amplified and conditioned using a standard physiology monitoring system (Solar 8000M, GE Healthcare, Waukesha, WI). Analog voltages are sampled at 100 Hz and digital data are logged on a bedside computer (PowerLab data acquisition system and LabChart Pro software; ADInstruments, Colorado Springs, CO).
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CSF Pressure values in mm H2O
measured @ LP*
Acute IIH Chronic IIH Normal Obese Normal Lean
Average 343.9 253 167 SD 36.46 136 SD37.6
Range 200-550(100%)
>250 (90%) >250 (28%)
200-250(44%) 200-250(25%)
<200 (28%)
*no sedation, local, 22-gauge needle, <1 ml of CSF loss,
left lateral decubitus,head and legs extended, pressure recorded for 1'
Revised Criteria: Adults: 5-25 cm, Children: 5-28 cm
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Normal continuous Intracranial PressureChart Window
Heart
Ra...
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EKG
(m
V)
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6:01:50 PM 6:02:00 PM 6:02:10 PM 6:02:20 PM 6:02:30 PM 6:02:40 PM 6:02:50 PM
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Chart Window
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%)
707580859095
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(V)
0123
5:59:20 PM 5:59:40 PM 6:00:00 PM 6:00:20 PM 6:00:40 PM 6:01:00 PM
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Chart Window
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(V)
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8:49:30 PM 8:49:40 PM 8:49:50 PM 8:50:00 PM 8:50:10 PM 8:50:20 PM 8:50:30 PM 8:50:40 PM 8:50:50 PM 8:51:00 PM
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Chart Window
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Chart Window
Heart
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2:11:40 AM2:13:20 AM2:15:00 AM2:16:40 AM2:18:20 AM2:20:00 AM2:21:40 AM2:23:20 AM2:25:00 AM2:26:40 AM2:28:20 AM2:30:00 AM
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Chart Window
Heart
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0123
2:56:40 AM 2:58:20 AM 3:00:00 AM 3:01:40 AM 3:03:20 AM 3:05:00 AM 3:06:40 AM 3:08:20 AM
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Continuous ICP Monitoring – IIH
(LP opening pressure: 19 cm H2O)Chart Window
Hea
rt ...
20406080100120140
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(m
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pirat
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12:18:20 AM 12:20:00 AM 12:21:40 AM 12:23:20 AM 12:25:00 AM 12:26:40 AM 12:28:20 AM 12:30:00 AM
Mean ICP > 20 mm Hg (26 cm H2O) for over 35 minutes
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? IIHWOP, multiple shunts: Headache –
10/10, no papilledema, normal cICP recordingChart Window
Heart
Rate
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(m
V)
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irations
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Skull based CSF Leaks
• CSF otorrhea and rhinorrhea can be congenital, post blunt head trauma, cranial or endoscopic surgery, or spontaneous
• Spontaneous idiopathic CSF leaks are 25–87% more likely to recur after surgical closure•Hubbard et al, Spontaneous cerebrospinal fluid rhinorrhea: Evolving concepts in diagnosis and surgical management based on the Mayo Clinic experience from 1970 through 1981. Neurosurgery 16:314–321, 1985•Ommaya et al, Nontraumatic cerebrospinal fluid rhinorrhea. J Neurol Neurosurg Psychiatr 31:214–215, 1968
• Pseudotumor cerebri and spontaneous CSF leak share common risk factors
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CSF Otorrhea & Rhinorrhea
• Non-traumatic
cases have higher
incidence of
surgical failure
• Some have
findings of empty
sella - ?forme
fruste of PTC
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CSF Otorrhea & Rhinorrhea -
preopChart Window
EKG
(m
...
-1000-500
0500
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Resp
iratio
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mH
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CSF Otorrhea & Rhinorrhea –
post-opChart Window
Hea
rt R
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EKG
(m
V)
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pira
tions
(...
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mH
g)
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)
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7:07:30 AM 7:08:20 AM 7:09:10 AM 7:10:00 AM 7:10:50 AM 7:11:40 AM
25% need Diamox postop and 5% shunts
Perioperative continuous cerebrospinal fluid pressure monitoring in patients with spontaneous cerebrospinal fluid leaks: Reh DD, Gallia GL, Ramanathan M, Solomon D, Moghekar A, Ishii M, Lane AP. Am J Rhinol Allergy. 2010 May-Jun;24(3):238-43.
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Perioperative ICP management of
spontaneous skull based CSF Leaks
• Neuro-ophthalmology assessment
• Lumbar puncture
• Sleep study – mandibular advancement
device for OSA, NOT CPAP
• Lumbar continuous ICP Monitoring pre-
op and post-op
Perioperative continuous cerebrospinal fluid pressure monitoring in patients with spontaneous cerebrospinal fluid leaks. Xie YJ, Shargorodsky J, Lane AP, Ishii M, Solomon D, Moghekar A, Gallia GL, Reh DD. Int Forum Allergy Rhinol. 2015 Jan;5(1):71-7
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What are normal intracranial (not lumbar)
pressures when upright ?
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11 patients with hydrocephalus, posterior fossa tumors and aqueductal stenosis etc
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Location matters
3-4 cm
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What is normative CSF pressure in
the sitting/standing position
Author N Subjects Reference Range
Chapman-
Cossman8 patients Foramen of Monro -5 to +5 cm H2O
Loman 13 normals Cisterna magna -8.5 to +4.5 cm of H2O
Bradley 1 patient Convexity -16.5 cm H2O
Fox 18 patients Foramen of Monro -14 to +7 cm
Andresen 4 normals Convexity -10 to 0 mm Hg
Juhler 4 normals Convexity -9 to 0 mm Hg
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What is low pressure?
Less than -10 mm Hg when monitored by
a parenchymal transducer in the cortex.
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Supine
LabChart Window
H...
-0 sitt
ing u
p
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open
zero
standin
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E...
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mm
Hg)
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2:19:00 PM 2:19:30 PM 2:20:00 PM 2:20:30 PM 2:22:00 PM 2:22:30 PM 2:23:00 PM 2:26:00 PM2829 30 32 33
8/27/2008 2:18:58.016 PM 8/27/2008 2:21:52.216 PM
SupineSitting Standing
Normal ICP change with position
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ICP changes with sitting in a EDS patient with
no classic MRI brain findings over 60 mins
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LabChart Reader WindowH
eart
Rate
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supin
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10:50:00 AM 10:55:00 AM 11:00:00 AM 11:05:00 AM 11:10:00 AM 11:15:00 AM 11:20:00 AM1 2 3 4 5 6 7 8 9 10
Severe orthostatic headaches; negative imaging
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Sitting up in bed
LabChart Window
Heart
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mm
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Hg)
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%)
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8:15:00 PM 8:20:00 PM 8:25:00 PM 8:30:00 PM 8:35:00 PM 8:40:00 PM
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CSF Leak s/p multilevel epidural blood/fibrin
patches with persistent orthostatic symptomsLabChart Reader Window
Heart
Rate
...
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alv
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sitt
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hair
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Multi-level perineural cysts Day 1
baseline monitoring, sitting up
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Day 2 after 4 multilevel blood/fibrin
patches
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Day 3 after an additional 2 levels
were targeted
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Spinal CSF Leak – baseline Day 1
monitoring - supine
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Day 2 – post patch rebound
hypertension - supineMean CSFP was greater or equal to 19 mm Hg (about 25 cm water) for 27 mins (8.7% of the recording) and greater or equal to 15 mm Hg (about 20 cm water) for 64 (20.5%). Mean peak CSFP ranged from 9.3 to 42.5, with average mean peak CSF of 16.1. Mean peak CSFP was greater or equal to 25 for 25 minutes (8.0%). Mean waveform amplitude was 5.6, and ranged from 2.9 to 18.5. Mean waveform amplitude was greater than or equal to 5 for 142 minutes (45.5%).
LabChart Window
Heart
Ra...
-0
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EKG
(...
-1000
0
Resp
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ICP (
mm
Hg)
(mm
Hg)
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2 (
...
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PPG
...
02
2:28:10 AM 2:28:20 AM 2:28:30 AM 2:28:40 AM 2:28:50 AM 2:29:00 AM 2:29:10 AM 2:29:20 AM 2:29:30 AM
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• Prior to endoscopic endonasal repair, a lumbar spinal catheter was inserted
• Overnight CSF pressure monitoring revealed CSF pressure greater or equal to 19 mm Hg 11% of the time.
• Mean CSF pulse waveform amplitude was greater than 5 mm Hg for 53.4% of the time.
• Lumbar drainage was performed for 3 days
• Overnight post-operative CSF pressure monitoring showed CSF pressure greater than 19 mm Hg only 5.6%
of the time.
• Positional CSF pressure testing was done…
Skull based CSF leak
A 61 year-old male with beta-2 transferrin positive left-sided rhinorrhea
BMI was 26.6, no clinical history of obstructive sleep apnea, meningitis, trauma, or sinonasal/cranial surgery.
• High-resolution CT showed left sided planum
sphenoidale defect
• T2-weighted MR demonstrated left sided
meningoencephalocele extending into the left
sphenoid sinus
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LabChart Window
Hear.
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head n
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ight
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neutr
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Hg)
(mm
Hg)
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(V)
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7:54:20 PM 7:54:40 PM 7:55:00 PM 7:55:20 PM 7:55:40 PM 7:56:00 PM 7:56:20 PM 7:56:40 PM4 5 6 7 8
Supine CSF Pressure Recordings
Head right = 32.5 mm Hg
(44.2 cm H20)
Head left = 36.8 mm Hg
(50 cm H20),
Head neutral
Head leftHead right
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Angiography demonstrates focal transverse venous sinus stenosis
Pre stent
Post stent
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R IJV
L IJV
R s
igm
oid
torc
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L s
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oid
Dis
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S
Dis
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Pre-stent
Post- Left transverse sinus stent
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LabChart Window
CVP (
mm
Hg)
-0
5
10
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25
30
mic
roca
thete
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JV
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mH
g)
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5:26:30 PM 5:27:00 PM 5:27:30 PM 5:28:00 PM 5:28:30 PM 5:29:00 PM 5:29:30 PM 5:30:00 PM31 32 33 34 35 36 37 38 39
Post R transverse sinus stentPre stent
Eight months following stenting, the patient was weaned off acetazolamide and he remains
asymptomatic at 30 months follow up
Bilateral transverse sinus pressure gradient of
6.7 mm Hg across the areas of stenosis.
A 6 x 40 mm right transverse sinus stent was
then deployed in the right transverse sinus
Pressure gradients decreased to 0.4 mm Hg right
and 2.3 mm Hg left
One year following surgical leak repair he underwent a diagnostic
angiogram with cerebral venous sinus manometry
Venous Sinus Stenting in the Management of Patients with Intracranial Hypertension Manifesting with Skull Base Cerebrospinal Fluid Leaks. Iyer RR, Solomon D, Moghekar A, Goodwin CR, Stewart CM, Ishii M, Gailloud P, Gallia GL. World Neurosurg. 2017 Oct;106:103-112
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ICP Monitoring in large Tarlov Cysts
with no radiographic signs of leakAge Diagnoses Upright pressure
(mm Hg)Orthostatic headache
58 Tarlov cyst. -13 Yes49 Sacral dural cyst -16 Yes41 Sacral cyst -14 Yes49 Marfan syndrome
Sacral dorsal ectasias -25 Yes
25 Tarlov cyst -10.7 Yes36 Tarlov cysts -7 Yes39 Tethered cord syndrome, Tarlov cyst -20 Yes31 Sacral cyst -12 Yes66 Large sacral internal meningocele -5 Yes42 chronic low back pain, sacral dural cysts,
infertility, bicornuate uterus.-13 Yes
34 Occult spina bifidaMeningocele
-4 Yes
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cICP Implications post-treatment –
No straining……
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Effects of CoughingLabChart Window
Heart
Rat.
..
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100
EKG
...
0
500
Resp
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ICP (
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cough
SaO
2 (
%)
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100
PPG
(...
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4:47:45 PM 4:47:50 PM 4:47:55 PM 4:48:00 PM
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LabChart Window
Heart
Rat.
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cough
SaO
2 (
%)
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PPG
(...
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2
5:05:14 PM 5:05:16 PM 5:05:18 PM 5:05:20 PM 5:05:22 PM 5:05:24 PM 5:05:26 PM 5:05:28 PM
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Sleep Apnea related ICP elevations
Chart Window
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12:00:00 AM 12:03:20 AM 12:06:40 AM 12:10:00 AM 12:13:20 AM 12:16:40 AM 12:20:00 AM
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Heart
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1:41:40 AM 1:43:20 AM 1:45:00 AM 1:46:40 AM 1:48:20 AM 1:50:00 AM 1:51:40 AM 1:53:20 AM 1:55:00 AM 1:56:40 AM
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Chart Window
Heart
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EKG
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V)
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3:16:40 AM 3:18:20 AM 3:20:00 AM 3:21:40 AM 3:23:20 AM 3:25:00 AM 3:26:40 AM 3:28:20 AM 3:30:00 AM 3:31:40 AM 3:33:20 AM
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Practical Implications of cICP for
SIH post-treatment
• Sleep Apnea
• Body position
• Rebound intracranial hypertension
• Venous Stenosis
• Avoid futile treatment
• Guide appropriate treatment
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Complications
• Scalp infection: <1%
• Seizures: <1%
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ICP during a GTC Seizure –
exceeds CPP, O2 Sat dropsLabChart Window
Heart
...
0
100se
izure
EKG
(...
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3:15:00 AM 3:20:00 AM 3:25:00 AM 3:30:00 AM 3:35:00 AM 3:40:00 AM22
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Acknowledgments
Neurology
• Dr. Aruna Rao
• Dr. David Solomon
Neurosurgery
• Dr. Mark Luciano
Radiology
• Dr. Ferdinand Hui
• Dr. Majid Khan
• Dr. Ari Blitz
Neuroscience Nurses