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Introduction Biomedical Image Analysis Prof. Dr. Philippe Cattin MIAC, University of Basel Feb 22nd, 2016 Feb 22nd, 2016 Biomedical Image Analysis 1 of 27 21.02.2016 22:30 Contents 2 4 5 8 9 10 12 13 14 15 16 17 18 20 21 22 23 24 26 27 28 30 31 32 33 Prof. Dr. Philippe Cattin: Introduction Contents Abstract 1 Varia About Me About these Slides 2 My Research 2.1 Segmentation Segmentation of Facial Soft Tissues Segmentation of Spinal-Cord Segmentation of Spinal-Cord (2) 2.2 Organ Motion 4D MRI Mathematical Motion Model Principle/Motivation for MRgHIFU Motion Compensation Result Prediction from 2D Ultrasound MR and Ultrasound Fusion Prediction Results 2.3 Registration Smooth Deformation Model Artificial Example Example Registration with our Liver Images Example with our Liver Images Lung Motion 2.4 Augmented Reality and Navigation ARALPAN: Intra-op AR System Tablet-based Image-guided Therapy Inertia-based Navigation 2.5 Computer-Assisted Robot-guided Laser Osteotome Computer-Assisted Robot-guided Laser Osteotome SEM of Natural Bone SEM Piezoosteotome Cut Bone Laser Cut Bone Feb 22nd, 2016 Biomedical Image Analysis 2 of 27 21.02.2016 22:30

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Page 1: Introduction Contents - Biomedical Engineering · 2.5 Computer-Assisted Robot-guided Laser Osteotome Computer-Assisted Robot-guided Laser Osteotome SEM of Natural Bone SEM Piezoosteotome

Introduction

Biomedical Image Analysis

Prof. Dr. Philippe Cattin

MIAC, University of Basel

Feb 22nd, 2016

Feb 22nd, 2016Biomedical Image Analysis

1 of 27 21.02.2016 22:30

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Prof. Dr. Philippe Cattin: Introduction

Contents

Abstract

1 Varia

About Me

About these Slides

2 My Research

2.1 Segmentation

Segmentation of Facial Soft Tissues

Segmentation of Spinal-Cord

Segmentation of Spinal-Cord (2)

2.2 Organ Motion

4D MRI

Mathematical Motion Model

Principle/Motivation for MRgHIFU

Motion Compensation Result

Prediction from 2D Ultrasound

MR and Ultrasound Fusion

Prediction Results

2.3 Registration

Smooth Deformation Model

Artificial Example

Example Registration with our Liver Images

Example with our Liver Images

Lung Motion

2.4 Augmented Reality and Navigation

ARALPAN: Intra-op AR System

Tablet-based Image-guided Therapy

Inertia-based Navigation

2.5 Computer-Assisted Robot-guided Laser Osteotome

Computer-Assisted Robot-guided Laser Osteotome

SEM of Natural Bone

SEM Piezoosteotome Cut Bone

Laser Cut Bone

Feb 22nd, 2016Biomedical Image Analysis

2 of 27 21.02.2016 22:30

Page 2: Introduction Contents - Biomedical Engineering · 2.5 Computer-Assisted Robot-guided Laser Osteotome Computer-Assisted Robot-guided Laser Osteotome SEM of Natural Bone SEM Piezoosteotome

Feb 22nd, 2016Biomedical Image Analysis

(2)

Prof. Dr. Philippe Cattin: Introduction

Abstract

A short overview of the Medical Imaging Analysis projects that my group conducts.

3 of 27 21.02.2016 22:30

Varia

Feb 22nd, 2016Biomedical Image Analysis

(4)About Me

My Name: Philippe C. Cattin

Apprenticeship at BBC/ABB Baden (Physics Laboratory Technician)

HTL Brugg-Windisch (Computer Science)

ETH Zurich (Computer Science)

Ph.D. at the Institute of Robotics, ETH Zurich

"Biometric Authentication System Using Human Gait"

Post-Doc at the Computer Vision Lab, ETH Zurich

Head of the Medical Image Analysis Group, ETH Zurich

Assoc. Professor at the Medical Faculty of the University Basel

Name of the group "Medical Image Analysis Center (MIAC)"

4 of 27 21.02.2016 22:30

Page 3: Introduction Contents - Biomedical Engineering · 2.5 Computer-Assisted Robot-guided Laser Osteotome Computer-Assisted Robot-guided Laser Osteotome SEM of Natural Bone SEM Piezoosteotome

Feb 22nd, 2016Biomedical Image Analysis

Varia

(5)

Prof. Dr. Philippe Cattin: Introduction

About these Slides

Generated with → hotspot/kilauea [http://www.sharpeleven.net/kilauea/]

All hotspot presentations are generated from an XML source file

A table of contents as well as all outline slides are generated automatically

Also usefull for online presentations

Allows to easily include formulas such as

Hotspot/Kilauea is not usefull if you prefer a GUI

5 of 27 21.02.2016 22:30

My Research

Segmentation

Feb 22nd, 2016Biomedical Image Analysis

(8)Segmentation of Facial Soft Tissues

Incorporation of statistical shape knowledge into the graph-cut segmentation process.

Masseter muscleChallenging task due to the high density artefacts

6 of 27 21.02.2016 22:30

Page 4: Introduction Contents - Biomedical Engineering · 2.5 Computer-Assisted Robot-guided Laser Osteotome Computer-Assisted Robot-guided Laser Osteotome SEM of Natural Bone SEM Piezoosteotome

Feb 22nd, 2016Biomedical Image Analysis

Segmentation

(9)

Prof. Dr. Philippe Cattin: Introduction

Segmentation of Spinal-Cord

Segmentation for sub-voxel atrophy measurement

(red) background, (green) foreground, (yellow)

automatic segmentation

(red) background, (green) foreground, (yellow)

automatic segmentationfine segmentation

7 of 27 21.02.2016 22:30

Feb 22nd, 2016Biomedical Image Analysis

Segmentation

(10)

Prof. Dr. Philippe Cattin: Introduction

Segmentation of Spinal-Cord (2)

Precision of of the area that corresponds to in the radius

8 of 27 21.02.2016 22:30

Page 5: Introduction Contents - Biomedical Engineering · 2.5 Computer-Assisted Robot-guided Laser Osteotome Computer-Assisted Robot-guided Laser Osteotome SEM of Natural Bone SEM Piezoosteotome

Organ Motion

Feb 22nd, 2016Biomedical Image Analysis

(12)4D MRI

Voxelsize , Frequency

Maximum Intensity Projection of the right liver lobe 4D Lung reconstruction, 24 sagittal slices, 11 stacks

9 of 27 21.02.2016 22:30

Feb 22nd, 2016Biomedical Image Analysis

Organ Motion

(13)

Prof. Dr. Philippe Cattin: Introduction

Mathematical Motion Model

4-Dimensional statistical liver motion model

10 of 27 21.02.2016 22:30

Page 6: Introduction Contents - Biomedical Engineering · 2.5 Computer-Assisted Robot-guided Laser Osteotome Computer-Assisted Robot-guided Laser Osteotome SEM of Natural Bone SEM Piezoosteotome

Feb 22nd, 2016Biomedical Image Analysis

Organ Motion

(14)

Prof. Dr. Philippe Cattin: Introduction

Principle/Motivation for MRgHIFU

Advantages

No radiation or chemotherapy

No bleeding

No surgery

Faster recovery

Minimal side effects

Principle of HIFU

HIFU Ablation

Respiratory Motion

11 of 27 21.02.2016 22:30

Feb 22nd, 2016Biomedical Image Analysis

Organ Motion

(15)

Prof. Dr. Philippe Cattin: Introduction

Motion Compensation Result

Prediction error with the atlas based approach

12 of 27 21.02.2016 22:30

Page 7: Introduction Contents - Biomedical Engineering · 2.5 Computer-Assisted Robot-guided Laser Osteotome Computer-Assisted Robot-guided Laser Osteotome SEM of Natural Bone SEM Piezoosteotome

Feb 22nd, 2016Biomedical Image Analysis

Organ Motion

(16)

Prof. Dr. Philippe Cattin: Introduction

Prediction from 2D Ultrasound

Given

A static 3D exhalation CT image

2D/3D Ultrasound image of the liver

Output

Prediction of the liver/lung position

13 of 27 21.02.2016 22:30

Feb 22nd, 2016Biomedical Image Analysis

Organ Motion

(17)

Prof. Dr. Philippe Cattin: Introduction

MR and Ultrasound Fusion

14 of 27 21.02.2016 22:30

Page 8: Introduction Contents - Biomedical Engineering · 2.5 Computer-Assisted Robot-guided Laser Osteotome Computer-Assisted Robot-guided Laser Osteotome SEM of Natural Bone SEM Piezoosteotome

Feb 22nd, 2016Biomedical Image Analysis

Organ Motion

(18)

Prof. Dr. Philippe Cattin: Introduction

Prediction Results

15 of 27 21.02.2016 22:30

Registration

Feb 22nd, 2016Biomedical Image Analysis

(20)Smooth Deformation Model

16 of 27 21.02.2016 22:30

Page 9: Introduction Contents - Biomedical Engineering · 2.5 Computer-Assisted Robot-guided Laser Osteotome Computer-Assisted Robot-guided Laser Osteotome SEM of Natural Bone SEM Piezoosteotome

Feb 22nd, 2016Biomedical Image Analysis

Registration

(21)

Prof. Dr. Philippe Cattin: Introduction

Artificial Example

Reference image Floating image Motion field

17 of 27 21.02.2016 22:30

Feb 22nd, 2016Biomedical Image Analysis

Registration

(22)

Prof. Dr. Philippe Cattin: Introduction

Example Registration with our Liver Images

Variational approach that simultaneously segments and registers.

Reference image Floating image Motion segmentation

(continuous cuts)

Motion field

18 of 27 21.02.2016 22:30

Page 10: Introduction Contents - Biomedical Engineering · 2.5 Computer-Assisted Robot-guided Laser Osteotome Computer-Assisted Robot-guided Laser Osteotome SEM of Natural Bone SEM Piezoosteotome

Feb 22nd, 2016Biomedical Image Analysis

Registration

(23)

Prof. Dr. Philippe Cattin: Introduction

Example with our Liver Images

Motion segmentation and motion field

19 of 27 21.02.2016 22:30

Feb 22nd, 2016Biomedical Image Analysis

Registration

(24)

Prof. Dr. Philippe Cattin: Introduction

Lung Motion

20 of 27 21.02.2016 22:30

Page 11: Introduction Contents - Biomedical Engineering · 2.5 Computer-Assisted Robot-guided Laser Osteotome Computer-Assisted Robot-guided Laser Osteotome SEM of Natural Bone SEM Piezoosteotome

Augmented Reality and Navigation

Feb 22nd, 2016Biomedical Image Analysis

(26)ARALPAN: Intra-op AR System

21 of 27 21.02.2016 22:30

Feb 22nd, 2016Biomedical Image Analysis

Augmented Reality and Navigation

(27)

Prof. Dr. Philippe Cattin: Introduction

Tablet-based Image-guided Therapy

22 of 27 21.02.2016 22:30

Page 12: Introduction Contents - Biomedical Engineering · 2.5 Computer-Assisted Robot-guided Laser Osteotome Computer-Assisted Robot-guided Laser Osteotome SEM of Natural Bone SEM Piezoosteotome

Feb 22nd, 2016Biomedical Image Analysis

Augmented Reality and Navigation

(28)

Prof. Dr. Philippe Cattin: Introduction

Inertia-based Navigation

23 of 27 21.02.2016 22:30

Computer-Assisted Robot-guided LaserOsteotome

Feb 22nd, 2016Biomedical Image Analysis

(30)Computer-Assisted Robot-guided Laser Osteotome

24 of 27 21.02.2016 22:30

Page 13: Introduction Contents - Biomedical Engineering · 2.5 Computer-Assisted Robot-guided Laser Osteotome Computer-Assisted Robot-guided Laser Osteotome SEM of Natural Bone SEM Piezoosteotome

Feb 22nd, 2016Biomedical Image Analysis

Computer-Assisted Robot-guided Laser Osteotome

(31)

Prof. Dr. Philippe Cattin: Introduction

SEM of Natural Bone

25 of 27 21.02.2016 22:30

Feb 22nd, 2016Biomedical Image Analysis

Computer-Assisted Robot-guided Laser Osteotome

(32)

Prof. Dr. Philippe Cattin: Introduction

SEM Piezoosteotome Cut Bone

26 of 27 21.02.2016 22:30

Page 14: Introduction Contents - Biomedical Engineering · 2.5 Computer-Assisted Robot-guided Laser Osteotome Computer-Assisted Robot-guided Laser Osteotome SEM of Natural Bone SEM Piezoosteotome

Feb 22nd, 2016Biomedical Image Analysis

Computer-Assisted Robot-guided Laser Osteotome

(33)

Prof. Dr. Philippe Cattin: Introduction

Laser Cut Bone

27 of 27 21.02.2016 22:30