introduction: maximising the yield
TRANSCRIPT
David Price, REG Chairman
2015 REG Winter Summit: Welcome
Welcome!Many Miles
Travelled to be here today.
Thank you for your time &
commitment to REG
Housekeeping & “rules of engagement”• Mobile phones
• Please switch off / to silent• Regular coffee breaks if you do need to pick up emails
• Recording & Photography for:o Internal reference; meeting report; newsletter & (with
consent) website• Toilets / Rest rooms
• TBC on the day• Delegate pack
• Programme• Abstract book – for all thematic sessions & select plenaries• Maps – directions to dinner tonight• Expenses form – emailed for completion on your return
• Sessions • Q&A welcomed – discussion & debate is strongly
encouraged
Looking back; looking forward…
2014 2015
2014: off to a good start…
2015
Arch Supplement• Published by ATS Annals• 7 papers discussing the key
aspects of real-life research:o Guideline limitationso The role of RWEo Standardso Cost-effectiveness
EAACI 2015 Conference proposals accepted• Harnessing primary care databases to unpick the
complexities of allergic obstructive airway disease7 papers discussing the key aspects of real-life research
• From efficacy-based to effectiveness-based guidelines in asthma: a paradigm shift?
Initial wish in 2012/13
“Set up a short-term initiative that will raise the quality and profile of real-life (respiratory) research across the research, political and public arenas”
But… 2014 required REG to recognise its longevity…
2014: REG continued to grow…COLLABORATORS
SUPPORTERS
2014: Recognising our longevity (II)
Initial Structure
Constitution+
2014: Recognising our longevity (II)
More formal structure required: • Oversight
Committee; • Council;
Special Interest Leads;
• Society Leads;
• Regional Leads;
• Guideline Leads;
• Accreditation Committee; Manuscript & Research Review Committees
2014: “Manageable chunks”
2014: Formalised call for research ideas
• Research Pin board• Studies shortlisted for
funding as:1. REG Studies (non-
commercial, with multi-sponsors or hands-off grant);
2. REG Collaborations (single-sponsor, non-commercials study), or
3. Commercial Study (commercial/product-specific study).
2014 Research: understanding real practice• Asthma State of the Union • Rationale: poor control may contribute
significantly to the health and economic consequences of asthma
• A study characterising asthma severity, treatment and control among patients from 153 UK primary care practices. Addresses questions around:o Exacerbation risk at different GINA
treatment stepo Possible over-treatment of patients
(at higher GINA step)o Differential outcomes for smokers/non-
smokers • Submitted to EACCI 2015; Manuscript in
development
TREATMENT
CONTROL
RISK?
2014: June Summit
2014: June Summit
2014 ERS…• Real-life session:
The Evolving Role of Real Life Research in Respiratory Medicine
• Collaborators meeting• 6 abstracts from REG
studies:o REG Endpoint
Validation Study:o Paediatric Asthma
Step-Upo COPD Eosinophil
Study
• Real-life session:The Evolving Role of Real Life Research in Respiratory Medicine
• Collaborators meeting• Real-life research course – run by
Research Education Alliance – materials to be accredited by REG
2014: APSR…
Looking forward…
2014
2015To all who contributed to REG’s many activities and successes
THANK YOU
• ERS session proposal submitted• Session at the ATS – Jerry Krishnan & Barry Make • EAACI sessions• EAACI Taskforce completing its work• Completion & publication of current REG studies:
o Asthma risk predictorso Blood eosinophils in COPDo Longitudinal bi-directional
relationship between ICS adherence and asthma
outcomeso Asthma Endpoint Validationo COPD risk predictiono Devices – iHARP & Critikal
2015: lots to look forward to (I)
• More research• More meetings• PR-activities – make the world start to sit up and take
notice• Possible joint society taskforce application…?• Potential Horizon 2020 bid…?
Next 48 hours – the summit…
• Opportunity to:o Share and learn from each other’s datao Identify new data resources and opportuntieso Strengthen relationships and extend our
networkso Identify new ideas and opportunities for REG
and for your own research interests
• And much more
• Hand over to Dermot Ryan for his opening talk:Maximizing the Yield: towards patient-centred care