Lecture 6

ETY494 – Introduction to Biomedical Engineering (2019 Spring Semester)

MATERIALS SCIENCE AND TECHNOLOGY DEPARTMENT UNIVERSITY OF CRETE

Cloning What is tissue engineering Building blocks Biomaterials Bioreactors Cells

Type of human cells Cell differentiation

2

3 https://www.youtube.com/watch?v=k1a2larfMIA

4 https://www.youtube.com/watch?v=kkvslrfaCLY

Genetic Engineering

5

Cell Engineering

Tissue Engineering

Organ Engineering

Human Engineering ???

https://geneticliteracyproject.org/2018/01/16/crispr-answer-genetic-engineerings-prayers/

https://www.nature.com/scitable/topicpage/what-is-a-cell-14023083

https://www.proprofs.com/quiz-school/story.php?title=tissue-quiz

https://www.icems.kyoto-u.ac.jp/en/originality/tissue/

https://back-shop.com/the-spine-perfect-human-engineering/

A large mass of similar cells that make up a part of an organism and perform a specific function

6

https://rontherapist.wordpress.com/2012/10/24/connective-tissue-the-very-basics/

7 https://slideplayer.com/slide/10510567/

8 https://slideplayer.com/slide/8690848/

9

10 https://www.youtube.com/watch?v=TLVwELDMDWs

Are engineered cells enough to give solutions?

11 https://geneticliteracyproject.org/2017/12/05/genetic-engineering-synthetic-biology-poised-boost-photosynthesis-carbon-capture/

12 https://jisakos.bmj.com/content/2/2/60

Growth factors Signals

Biocompatibility Porosity Degradability Mechanical matrix

Stem Cells

13 https://www.oshasafetymanagement.com/blog/establishing-scaffold-safety-guidelines-training/

Allow cell attachment and migration Deliver and retain cells and biochemical

factors Enable diffusion of vital cell nutrients and

expressed products Exert certain mechanical and biological

influences to modify the behavior of the cell phase

Need a certain porosity, biodegradability,

15 https://www.popsci.com/consent.php?redirect=https%3a%2f%2fwww.popsci.com%2fscience%2farticle%2f2013-07%2fartificial-human-ear-good-shape

Why you think this "might" be important?

16 “Additive manufacturing of tissues and organs” https://www.sciencedirect.com/science/article/pii/S0079670011001328

CONDITIONS STRATEGIES

17

Birla, Ravi - Introduction to tissue engineering applications and challenges, Wiley-IEEE Press (2013)

https://www.worldkidneyday.org/faqs/topics/cardiovascular-disease/

Acute myocardial failure Atherosklerosis Valve stenosis Hypoplastic left heart

syndrome

Pharmacological agents Mechanical devices Pumps

Surgical interventions Heart transplantation

https://en.wikipedia.org/wiki/Hypoplastic_left_heart_syndrome

https://www.labroots.com/trending/cardiology/2335/preventing-heart-failure-after-acute-myocardial-infarction

18 https://www.organdonor.gov/statistics-stories/statistics.html

19 https://www.prosancons.com/education/pros-and-cons-of-statistics/

20 https://unos.org/data/

CURRENT

Uses mechanical components

Biomaterials (as defined in Lecture 4)

OBJECTIVE OF T.E.

Fabricate biological artificial organs that are similar in form and function to mammalian organs

Uses a combination of cells, biomaterials, and engineering technologies

21

Cardiovascular Heart muscle Blood vessels Valves Cell based cardiac pump Ventricles Bioartificial heart

22

https://www.freepik.com/free-photos-vectors/cell https://www.britannica.com/science/blood-vesse

https://www.cardiosmart.org/heartvalvedisease

https://www.science20.com/news/engineering_the_heart_piece_by_piece

https://www.thoughtco.com/ventricles-of-the-heart-373254

http://www.medicalautomation.org/2014/07/3-d-printing-a-bioartificial-heart/

23 https://www.youtube.com/watch?v=HU_pgHlWsdc

Musculoskeletal Bone

Cartilage

Skeletal muscle

Tendons

24 https://clinicalposters.com/products/musculoskeletal-system-22x28?variant=5160524873761

Urinary system Kindney

Urinary bladder

Ureters

Urethras

25 https://www.pharmamad.com/271-2/

https://nurseslabs.com/urinary-system/

Airway system Artificial trachea

Artificial lung tissue

26 https://myhealth.alberta.ca/Health/Pages/conditions.aspx?hwid=hw144088

Digestive system Artificial liver tissue

Pancreas

Intestine tissue

Esophageal tissue

27 https://www.scientificpublishing.com/product/the-digestive-system/

Artificial skin

Central nervous system

28

http://www.orissapost.com/scientists-develop-artificial-skin-with-superpowers/

http://www.richardsonthebrain.com/central-nervous-system

29 https://www.youtube.com/watch?v=7Q3S6q97FiU

30 (IEEE Press series in biomedical engineering) Birla, Ravi - Introduction to tissue engineering _ applications and challenges-Wiley-IEEE Press (2013)

https://www.researchgate.net/publication/315589595_Stem_cell_homing-based_tissue_engineering_using_bioactive_materials

http://3d2go.com.ph/blog/breakthrough-applications-of-3d-printing-for-healthcare-and-medical-science/

33 https://www.youtube.com/watch?v=u468xY1T8fw