introduction to breastcancertrials -...
TRANSCRIPT
Introduction to BreastCancerTrials.org
Elly Cohen, Ph.D
Current Approaches & Emerging Advances in Metastatic Breast Cancer
Metastatic Breast Cancer Network Annual Meeting
October 16, 2010
A Clinical Trial is a type of
research study that tests how well new medical approaches work in people.
NCI Dictionary of Cancer Terms
Treatment
Symptom management
Quality of life/supportive care
Screening and diagnosis
Prevention
Access:
◦ To the latest medical knowledge
◦ To experimental treatment when routine care is no longer working
Information:
◦ Decisions based upon all options
Every advance in breast cancer has been the result of a clinical trial
Hand-in-hand with scientific discovery
“Bench-to-Bedside”
Scientific laboratory to the doctor’s office
Daughter of President John Adams
◦ 1809: Discovered lump in her breast
◦ 1811: Breast removed
Surgery in the Adam’s family home
No anesthesia
No sterile technique
◦ 1813:Died at the age of 46
225 innovative drugs in developmentBreast Cancer - Drug Pipeline Analysis and Market Forecasts to 2016
1858 1970
<1970
• Surgery• Radiation
• Chemotherapy• Hormone
Therapy
>1970
• Targeted therapy• Herceptin®• Lapatinib®
>1998
2010
Compares safety and effectiveness to standard care
Randomized
Blinded
FDA Approval
Randomized to control = “no treatment”
◦ Control Group:
◦ Experimental Group:
Treated like a “guinea pig”◦ Care is carefully monitored by a research team◦ Participation is voluntary
Standard of care
Experimental treatment
Talk to your healthcare provider
Get a second opinion
◦ Academic Medical Center
◦ NCI or Community Cancer Center
◦ Private Practice
Use the Internet
◦ Personalized matching tool
◦ Patient-friendly trial information
◦ 2005: Pilot
◦ 2008: Nationwide service
Joanne
Tyler
Joan
Schreiner
Demo
www.BreastCancerTrials.org
Tutorial: http://BreastCancerTrials.org/bct_nation/tutorial/index.seam
10 new trials/week
• 256 Treatment• 60% Adv./Metastatic
• 40% Early stage/DCIS
• 84 Supportive/QOL
• 21 Prevention
• 62 Other
LAUNCHEDOct. 2008
30 Trials
October
2010
423 Trials(53% of U.S Trials)
Weekly email alert
Over 1600 subscribers
Return visits account for 40% of traffic
Less 5% of eligible adult cancer patients participate in trials
New York Times, August 2009
Consideration of trials is the norm vs. the exception
Trials discussed as a routine option for care
Thank you
Visit us at: www.BreastCancerTrials.org