Office of Science EducationNational Institutes of HealthDepartment of Health and Human Services

Introduction to the National Institutes of Health

DHHS Agencies

• Administration for Children and Families (ACF)• Administration on Aging (AoA)• Agency for Healthcare Research and Quality (AHRQ)• Agency for Toxic Substances & Disease Registry (ATSDR)• Centers for Disease Control (CDC)• Centers for Medicare and Medicaid Services (CMS)• Food and Drug Administration (FDA)• Indian Health Service (IHS) • National Institutes of Health (NIH)• Program Support Center (PSC)• Substance Abuse & Mental Health Administration (SAMHSA)

NIAIDHamilton, MT

NIHBethesda, MD

NIEHSRaleigh/Durham, NC

NIDDKPhoenix, AZ

NIA, NIDABaltimore, MD

NIHBethesda, MD

NIEHSRaleigh/Durham, NC

Frederick, MD

Baltimore, MD

Bethesda, MD

Frederick, MD

Baltimore, MD

Bethesda, MD

National Institutesof Health Bethesda, MD

National Institutesof Health Bethesda, MD

The NIH has 75 buildings on 322 acres in Bethesda, Maryland

NIH Mission Statement

• NIH is the steward of medical and behavioral research for the Nation. Its mission is science in pursuit of fundamental knowledge about the nature and behavior of living systems and the application of that knowledge to extend healthy life and reduce the burdens of illness and disability. The goals of the agency are as follows:

• 1) foster fundamental creative discoveries, innovative research strategies, and their applications as a basis to advance significantly the Nation's capacity to protect and improve health;

• 2) develop, maintain, and renew scientific human and physical resources that will assure the Nation's capability to prevent disease;

• 3) expand the knowledge base in medical and associated sciences in order to enhance the Nation's economic well-being and ensure a continued high return on the public investment in research; and

• 4) exemplify and promote the highest level of scientific integrity, public accountability, and social responsibility in the conduct of science.

National Institutes of Health

• Organized into an Office of the Director

& 27 Institutes and Centers

• 18,000+ employees

• Budget• FY200327.173 Billion• FY200428.028 Billion• FY2005 28.757 Billion (President’s Budget)

= Extramural only

NEI

NCI

NHLBI

NLM NINDS

NIMH

NIAMS

NINR

NCCAM

CIT

CC

NHGRI

NIA

NIAAANIAID

NICHD

NIDCD

NIDCR

NIDDK

NIDA

NIEHS

OD

NIGMSNCRR

NIBIBNCMHD

FIC CSR

NIH consists of 27 Institutes and Centers

The mission of the NIH is to uncover new knowledge that will lead to better health for everyone by:

conducting research in its own laboratories (intramural)

providing support for research conducted by scientists in universities, medical schools, hospitals, and other research institutions throughout the country and abroad (extramural)

training research investigators

fostering the communication of medical information

National Institutes of Health

Research Grants

71%

All Other 6%

Research Management& Support 3%

IntramuralResearch

10%R&DContracts

7%ResearchTraining

3%

(FY 2001 $20.3 billion)

Over 80% of NIH funds support extramural research

National Institutes of Health Budget

The world’s largest hospital devoted exclusively to clinical research.

250 beds

7,000 inpatient admissions a year

9,750 new patients a year

72,600 outpatient visits a year

1,200 physicians, dentists, and doctoral-levelresearchers

900 active clinical research protocols

Warren Grant Magnuson Clinical Center

Opened September 2004

Mark O. Hatfield Clinical Research Center

postbaccalaureate trainees

medical students

graduate students

postdoctoral and clinical fellows

summer students (high school, college, graduate, and medical)

tenure-track investigators

senior investigators

230

93

160

3,300

1,000

287

919

(2001 data)

How many researchers are at NIH?

Marshall W. Nirenberg, Ph.D., NHLBI (1968)Translated the genetic code of DNA and explained how it functions in the production of protein in the cell

Julius Axelrod, Ph.D., NIMH (1970) Discovered the regulation of neurotransmitters, chemicals involved in nerve cell communication, leading to therapies for disorders like depression

Christian B. Anfinsen, Ph.D., NIAMS (1972)Determined the relationship between the sequence of amino acids in proteins and their 3D structure

Nobel Laureates in the NIH Intramural Program

D. Carleton Gajdusek, M.D., NINDS (1976)Identified so-called slow viruses (now known as prions), which cause neurodegenerative diseases, and their mode of transmission

Martin Rodbell, Ph.D., NIEHS (1994)Discovered “G” proteins which trigger a cell’s response to outside signals, involved in normal activities and in diseases like cancer and cholera

Nobel Laureates in the NIH Intramural Program (Cont’d)

Joseph L. Goldstein, M.D. andMichael S. Brown, M.D.Paul J. Thomas Professors of Medicine and Gentetics, University of Texas Health Science Center at Dallas, Nobel Laureates

Philip Leder, M.D.John Emory Andrus Professor of Genetics at Harvard Medical School

Harold E. Varmus, M.D.Director, Memorial Sloan-Kettering Cancer Center, Nobel Laureate, and former director of the NIH

Distinguished scientists who trained at NIH

Francis S. Collins, M.D., Ph.D. Contributions to the success of the Human Genome Project

Anthony S. Fauci, M.D. Award-winning research, recognized for his seminal research into AIDS and other immune system diseases

NIH scientists in the news

www.nih.gov