16. IS THERE AN EMERGING EPIDEMIC OF PAPILLOHA VIRUS ASSOCIATED

CANCERS.

2. CANCER PREVENTION PROTOCOL.

Math6 0.. Battista C., Busutil I#., Hagipantelli R., Cartier

I ., Hill M., Billova J., Vovan M.L.

Service des Maladies Sanguines et Tumorales L I.C.I.G. (Univ.

Paris Sud, CNRS UA 04-1163, Assoc. Cl. Bernard 8 ARC),

Hopital Paul-Brousse, 94804 Villejuif, France.

Wehave in a first abstract described OUK investigation protocol. The

treatmentprotocolcomprises: firstthetreatmentof associated other

STD; second the systemic administration (phase II study) of retard-

D-Trp-6-LH-RH. Third in case of non complete regression, the laser

treatment or fluoro-uracil local application according to the

presentation of the lesions. Fourth a randomized trial with local

retinoid (tetrinoine) is conducted. Fifth a local application of 8

interferon is made if viroids are found at EM after the above

treatments. Then a systemic and local immunologic treatment with

bestatine and zinc is conducted, the indications and effect

evaluation are determined by CD4, CD8, NK and macrophage cell

evaluation.