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TRANSCRIPT
;;< ,- u > (Bz)C6H5CH'CH2ICAS N0. 100-42-51
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! J! L , i;% li!L "jR jjE!;:j T L 7:: "-~" '. 30oppm t l ll, }RllO> X + P > 1 K. '@ld: *:' > 5" 4 7 6>!;j (5A) @)liR !ki!! ;jt j !*j! ~jf Ljj:7!* 5j4jQjjRi , j;jmi!1!ii!lj ttiEo>j T l;:, tg C ,::7!. 0 t: 18. i!, i.Carpenter i:, "" !* X + , > 0> !!!Sit\ \Oli! *!t :1 ii?{j:m j= 0 \ . t , jl!0> !! {!:"< ; 0> ' *'L !: jLjjt L t ly* . ,.800 ppm @> X + P >' 0 4 1 11ji:lLOl!!*, 1;1: ,k 6 :Rl, f'Fml, : j !:it! lj:0> F JV. :. > J: b {, j;:j7!. 0 i::. 1!q !;, *.;*:jlj{ R*,
Ethenylbenzene. Ethylbenzol. Phenylethylene. L j;llj41 j;,;j ,\0>%iliit'11;1t 200 ppm !;!1: (4 11 1!11) ti'Vinylbenzene
tl!;;$i;L fti
l. 4 i L{i::;*rt . M;ftx + P > i, :, 5i. T. tit 104.16, J1: 0.9069 (20C ), ft j - 30.6 C. iJ1;, 1145.2 t:. *; H: 5 torr (4.5 mmHg.20 t:) @>'i 'i Lf;;D:t:'! f9. ~ftf9.0tttl' f t, 'H' < 4ilj j" ;g: !; L . , :. t*: 0 . 1;!t:t ltq { lt 0.04 ~ 0.08 ppm 7j. i:,O. 32 ppm t: *ltt ' $ f'L, 1= F t lt; .!i ;!= 1!;!j:t4itt '7!t;!S CZ,. zklC *> *7, .!=j i, ' (20 C t:' 300 mg/L). ,:- ' / ~)L, =c. - 5 iu, 7 -tz } >,, =:iit{bb ;!$1=i !,', ,.2. 111it;ltO'{Ei!i lt
,i;U ;!.+ , >7d> x;!'. v ', f !;! =-5" 4 > #', x+L, >{Lsi$ U .Z. X 5" iP, 7 ,,' U D .= F U i, *, 7' :,,. z. > :.
f o i:: ill {1:t;i'q Zt O*{b . j '1 @> Tjllllli!E4 }: L tli: < { m *Lt\*. ,. i998 fF@> B :j*0{Eit;tE7i1* 3.167.000 F>. td;, 0 ;t: 11.
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l, } 'C! X + P ;,!!!tqi(lit0 97 %i5tl . !={ ; !j 1!: L.Cj!j:jjlt *, L;J, " . ;j:/:: ,J, jj rpf jgl!j9jj*:? >. 5" J!,,;: (MA)!: 7 = = JP 'J :d', t" :,'iVi : (PGA) C'; >. , " *"i. MA -,*: > *iP 7 JV . - JV~'ZJ, .'iS'i!f~1! ii1!! @>*;E, 61t7 4 +- 'C'. :$:{t;!tO> lO %i;!Tt:'!*>. , !: ,*b *Le fy*, ,. ji q.l. ;!1;j ; *L . , MA, PGA. .!!$ lj g;: 0> 1L !f;!, . *L ' *L56.9 %, 33.0 %, 7.8 %t:,;*,, , " . i, F t:'0> MA oli il.{!Fii i* 2 *il' , C*, :j5j4:iUj!J: *s J: . 4 11 :1&i ;: 25 1 11!1t8i,
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i!,@>{ ;91 (cytochrome P-450 *tm!!t\;'4'. ,), ;<+ P > *"U = - i, - MA 0{ ;!; ( 7 )P , - ), tt>,J, l.!t7 .1= 1* 7iP 5" t= lJl
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4.1, i !jjj!j i\0>!; \
rat'C'!ti;&LI LDs0 1* 5000 mg/kg fJ';!t " ', LC, , 1*rat'C'2770 ppm (4 !1 111111!*,;;), mouse 't'4.940 ppm (2ll jllj1! ,;;) 7, '*1tf!; *'Lt V . , , 13- iti.4.1.2 1= F'\0!, q. 1!1:;j!??!!
;j< > 5" { 7 1= J:,J, Wfg 'C. ? t? X +z - 7'4 'i! L'C350 ppm <i' 306i'll!i. 150 :i!: 1 380 ppm i' l llt;11!1. 50 /::1* 200 ppm t 1.5 11 1111@) X + b ;,
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e C o i::*t 2 11*'1!11@>11!*t!;t'1, : 350 ppm t t> C @> J: ;g:!f 4!1!1, : Fi! it ,:: . o t: " . {1: ! j*ii ::: , Ci*!., L, !F; .!. 1!9 L C 1*;, 50 ~ 100 ppm o> x + P > 1 A ,, 5F J 92 ppm O>fl:;!!$i7iti'@)1* i&;?:'iii; . 7i'J{i;2;1=JWji Lj:: 17 21i!: *jtj ' *'Lt V ., , 7jS IO : /:: jt 35 ppm @>1 *,%;;jj\1, "C',, . @> J: ;) ,:: 8F.:;. 0>1 1Jlllt3 ., b l;> *L;*:i!*o j:: - z:ii.Stewart i " ' lJ: 9 A03i< > 5'. { 7 4 . 50. 100, 216,376 ppm @> X + , > 1=!it;k: 7 1*t11j!*i!; *t'/::. 50 ppmti' l li'$ lllll *t;; :", 1*;t: 3i$ ' > 5" 4 7 1. 1d:, :!iE < 1 ii:{ 4}: ';2;!:!!tl ;;: Eiil*:i:i!i! ld:;::7i. 0 /::. L *' L IOO ppm l t C'1, :, 2p
!;k@> Ai: t* L . ~ rr$ ttty : 1;1it;, i;;}: :. ii L , 376
ppm 'C l, :1 !: A, !:'0 /\ iit;F'lJ! ti: 1:1!it, i;:1}: }: , 1cy; ! *' ;::!$gy 0)JISl :';i L t:.
4.2 :1; :!911!*t!;@> l= } !=*3 1i' 6 !t *!!!42.1 -,"!ti ;'kL
900 A@>j ;t:F! 0> jl!L75. ,;,, j; !Uj!.*, t:.J, X + P 7 11!*?j!. J: .J,!j{:lt j ,ljijj +$:
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*:0>* , j* j=0 \ , t o>ffj;;jj;!,:j i:,*'L;::r *0 ,t:7!* 11!\:!!;'\@>1ili;!t '$!ii1 0> :4;i;1* 50 ppm 'C'!l: " : , !: *!! ; *i. c v . , z-i.
4.2.2 *111i; *!t' (i) thl!*i;fT!L!i5' x }l) *if ili!L "1; iiE (i ;1;E ln ' i 'El;)
Lindstrom ;;, " ' jJ:, 98 A@) x+ P >lU*j ,}j (51Z Jl!!#,i;i 1!E 25 ppm, 4'4 Jl "1;iVll!!i 4.9 t3.2ff:) 1=$ f *;!: :5" >!. } (Mira test) :' tf, ., 1@ ii !i 'Cld;*;OT5; t,1 (hand steadiness) 7it*i'!!t!1;F!:JL 'C4i;1 ;;=f T L,*, 0! !i'1', MA il 1;E t: $ j t;!tj:5" X F O*li!! !: @) lllj!= ! l!!1 !;7i<85 0 i:: !: *ftj!j L t L .. ,. ;pjl 0>T5j . M: . ! , +} >$' 7 +5" X F (Santa Ana) 1=1 L t! , Fallas i;, "(n = 60, '1' Jl* i*;i!! i;E 24.3 ppm, 514 Jl t !Vjl!lj6.5 t 3.75 fF) 1. J: o t X + , > 1! i tO!;i?\4:1*: !i! 1;, it ti:\. !: \ itt V*. , 75t Flodin !:, 1* ":$j" 1 A, 1;1j (:14
Jl!*t;;i! 1&: 11.8 ppm) ld:f i 1 1 t%ll\ (lU t!;il i 5.9 ppm l;\Ti J: b x :2 7ri*
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Lt\.Z, " '. j :1, ;11. }1!1j (reaction time) 1=1 Lt! ,Cherry ,:, " ' !,: !;el, C;ll :1!1i @>i! ! (n = 27. :'14J*Jl!#,;;\ 92 = 46 ppm). i !=iiiiij, ;!.. f. U ;, jj lj!:*t5,1 /!mol/!>!:i i@)flkil 1 1! i, ;\'c i;t, x -f. u > 1!!*, 1;f @>ll llll*i;i!t !.J: o t l;<!. b;llt:1111@) 11j '!L l;, ,ti::7i' i\\iil 1 1! "!;1!tC !t!L i it;5:i, .o it: !:/ \ ;'iL tv, ; ,. t! 'k!* : ;t:, 17 A@)X+ , > 1!*,!;f'i' ('1' Jl t;;i1$1;!: 20 ppm) 0>i;T:*lll !;**' . i, Ci, ,;llt:llli !: 1, < il! MA i&1 != !* i i&!*t3!, ; , !: fk. i Ltv. ; , "'. 1',}jtO {lt;!f!*; jegaden l;, " 1= J: o t {, : *'LC, *Z, (n = 30, ,14 Jl!*, 1;il$liE 22.7 ppm, '1' Jl
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,3:iU11"1 5 4.5,1L). -: ', Schoenhuber 4, " ' (n = 55,'F i$1!;! 3*:i& 1;E 25 PPm), Fallas i4 " ', Ediing Q, 33i(n = 20, 5F Jl!;!fii j 1;E 8.6 ppm, 3jZi jR! i%:! jb, 9fF)!,;j;i:lb;, M!3:! ,$ !: *j WR !: 'C'i !*6:v. 1!: *Rj . Ltv.- ,. ;: *1 B:ii: :7J'7'>!. } (selective attention test) 1=j!q !, t j, :, ;< + P >!! fi80\iJ: tjev .1E *& jj. *Lt \ *6 32i.2) Ui}!!Mi16;tE 2. ;;Ui!&ldy (perceptural motor) 1 t lC
l!U L, t > v. <o ;,. 0 .7' >!. F *<tf*> *'Lt V. . ,. k, \:i9' ' " X l. (digitsymbol) @>*jj!j !=1! L. t j, :, Edljng 4, " ' !**j' jliF, L l)x = 7ify*{ T Lt, "/:: !: V. *R i! . LtV.
. , 1, , ;;k:*:t ' . " X F @>* !j !: x + P ;,'ll , g: fit . 0, ij!$, MA i! 1R:!:O llar != lt ;ii':t : ,: j!q ;!!*tdj, o i: : v * Letz , ""' @>O *E{ ,
(n = 105, 51Z;1 1!!*iE:i!&1;: 29.9 36.2 ppm, 5F Jll ,!;iUljla 2.9 * 4.6 ,F) *tt >.Z,. L*. L ,::*t , :i:' ' 6, $R ;
. ,;t, 1) Schoenhuber , ""', Yokoyama i;, " ' (n = ii,qZ j! , g:j&j;E (jjEii j!i) 26 = 24 ppm, 'Ft$ll&!ti;!! lU 4,j ) , Fallas i4 " ' i* v .f*'L {, !;t, j, :j :; . '. ;< F @>* J! 1tR!*fii; 3i: !: *t !! \* 'C'i ; *t ;:: v* E: *& j . L t v. .*, : t;:Yokoyama 4, " ' 1;t, * j"j5 :ii!: 7. } 1=1;U L 'Cl!!*i%;i# :*f !!i!%'C'* i :: 75tjZ&> , *L*: }: *R' UtL" ,.3) ; 't : : 32*;%: i!. 1: (memory) t!: a;";t ;lJ (cognition) 1=1!!! Ltl*,
Fallas i;, " ', Jegaden i;, " ', Edijng i;, ""' j= J: o t,,%;jjR0>j:3;i&!;:. lt;1 1Bi (choice reaction time) 13: t i;\J: b :4i': :1=f T L .c v *t:7j* jjtj;i:it;1!!!{ it ,: *. o t: !: *&;!} *'LC l, * ;E, . *;!. t!t E. $%7J '7" 7!. 1. (Benton) !. llU Ltj*, Fallas i " ' !c J: 0 'Cl ,%:i;* }: *, i! 3!: *R'i! *'Lt ,*,},. it*5'. X F (block design) ld:,Muttj , " ' ** j ij. MA j! 1;g !:. i!:iR;1;E@> '31'!: *. ' X l* 0> X . 7 != 1$:;jj :0>j!8;!;*t; !&b 4,*'Lt: !: *&' LC, *. , (n = 50, !1 ,!$i 1!E 10~300 ppm, EIZt$j!;!, 1;i! M 8.6 = 4.5, F). !:na. '>!. F (digit span) 1.1!T Ltl, :,Fal!as , " ' lJ:1 ,%:i;\ !: ** !&:'@
v. 6;fyt Jegaden i " ' 1a:{ ~F L'Cv. t:!: *&f . LtV. ;5 .: (memory) i=t L'Cl, :, 1! it"0 i'3;i'1!E3, '1: (10ng-
term verbal memory) !=Ov. t j:jnnLt: Muttj i;, 36i*< . rt, MA !:. 1 :i& :0
, . 3+ E:; :0*BWU75ti "5 Q,*L/:: &: $R{!5' L'CV. ,}, 1 75. *;iM8i!'li (short-term mem-ory) 1=0V. t Schoenhuber , " ' 7jtij! , MAj&j!E !: !!$! i;*i 1 @> f ','1'i 1 7!* 700 mg/! !;!L@> i%;i 19:1! E i!t'C',:jj: :0{ T*tt .&b ,:> *'L7t: !: *R{ ' L t V . Z,.4) t!Et6. (personality) }:!i! {!i (mood)Yokoyama i " ' != J: Z, !: * y '{usmiAf6'1 $ (MMPl) 1= 1;U L t l* X +
P > !! j :0\?q!1!id ;::;t. o it:. : i:: cherry ;> " ' ia:, !j . j;j (mood) !:im4, X+ P >i!!$j\:!= jt; ': :0*g1! 7j<j .&> 1;, *'Lt: !: * f! L t , *. ,.i;!_b l) ~ 4) '$:. 3: E: &>. , !:, : ' ;@> *t g&b ,*Li::5' ;< F /< v .7" U - @>i;or ;il* -. i* L , - i: L, t ,.;:: ,**t,;s, St, faX + P :,'1!! 38 25 ppm 7!'. i *ty$ j *mj. . x j~ j= !7j* g. &> Q, *'L;5 !: ' . 1;, i'L. ,.(2) !i!;! :;i
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il: E: CCl (p < 0.05), Ei:. d. X + b >, j !!E !: CCl (p = 0.02) @> 1 1= 1d:: i' :::* j i!g7!tj2. a> !;, *Lt:*g l . rl. MA i EE !: CCI O lun lC ld:"Ui ** aab i;, *L : **o j;: !: *& {;j' L 'C V. Z, lisy la; 0 *ft {!:'lg: pallas i;, '7),Campagna i:, "4 . " ' (n = 8i, SjZt$jl!! , g:j!T1!E48.4 PPm,
'E8:! nn 5 .E 4 fl') 'C {> ;6: *t. t , .. ,. Eguchj i:> " 'lt 57 )\@>X+ P >'!! , : ' (5Fi:li!! , S:i;$1:E 18.5 ppm, EFi ll8*i$i! 1" 7 fF) 'C, !! 3S\\0> CCl @>t lln .*& . LtV*. ,** Gobba Q, 0*1t '!: 1 ;:* b i; i 19:1! , ' (! Fh MA i&1;E 0.42 g/!i;!. L. ) 0>1S. 11. MA t!$S: !: CCT @> 1"!= !d::fi'i :;*:1;Ui!E:6t3a&> 1;, *'Lt: (p = 0.001) :
*R i L t\* 6 . : t: Campagna 4,!* Gobba q, @>'7'- ' !: 1 ,!! O; :. 0;;Rf! &:. . b 'C, 203 A@)1 : .@> *- -; .
L , !;k$!!!. 5"il, . i v* Cft\*lj L t:* !j , ;!. + P >'i&1;E 4ppm i;!t. 'C' CCT 1= \!!75*j .&> , t'L , 1!: jj jjti L, c * . 6, 40i.x*f. P > !!,$ !: = >. F x } t :ijl. 1!U L'Cl*, !j:E :
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$!$U Ei .$" MA i&1;E!:, 6 . U'12cycle 'C'@> . ? F X F*R. 7J @>j Tzigl li!: L t V* t: !: *&{:;
*'Lt v. ;Ji o> :. ti8,Z, .i;\L** ,, 7< + u >.! , , *'L, ;< . . V >'ig!!gi*, Z, V*ld:!7 q. MA i 1 1!: 0ft8 1= 1d:&t1 :1t;1!q{ 7itj2. d> 4>*'Lt:. 30 ppm* "EOtEl f i EE
t; 0>1 *t3$ E' .6 TtiEi !d8> ,. L**L $Ed;,.6, 5"- ' ** Q, iE :;::1 j : .*&> , Ol, :"E L\..2) 11S7J . 0' jj ;j !!3, 'i!= 1!U L 'C, Muijser i;, " ' jt 59 A@> X + P 3. '1!: , S::! ' ("!
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t8t!!1!t 14.4~32.5 ppm, Sp*$1"! ,;;!tWMi 8.6 6.5,F) !: 88 AO> t : ': .! v. 'C, 0.25 ~ 8 kHz @>1 ! 1i :!;ki:* !: , 8 ~ 20 kHz @> i 1 1i ;;qi!*'C '*L '*tBa{i 'i!1!$i:Lit:!: C Z, , 1 i*! E: *j i# 1*, ,. '*Lo lj ; i 'C {, jiqjjSlC*j : ld: g&> !> *Lt:75.0 t:75t 1* 3 %j Oj {$;1 3S * (EFJ 11 3Si;31;E 32.5 ppm) E: ll t ! : :3&(5pJ j! , g:j 1$: 14.4 ppm) '1;t, i 1 i &k! 'C0 . 6aljg!=;S" : *t ; . b , *t. t: !:*R. ' L, t\* ,. j!;: , j*, Li i, ,0> . ill$i != J: o C, 1! ,$t;Ft: ** &\tS6 .!= **,,:v. c !: t> m; g Lev. 6, @>'c', c @> i,x . . u >,!!:, g:1= J: , !: i!Eiftl *L ,. Mojler i;, " ' >, 18 )\@>X .?'. 1, . :,! ,8:$\ (5Fi j! iR;1;E 26 ppm, 5Fi 1! 3$ngi1M 10.8, F) 'Clt,*t'ft!!' ' (18 A) J: b t>11 7i@>{ T*t3g"> 4, *'Lt: }: *& ;;.L'C v*. , (E& . 1= J: Z,
!1*, , %&\ !: ** *\'C: ld: t*b*). -77'C Calabrese , ""' i* 20A@> x + P ;,. ll , g: ' (Ept:j, 38;i!S19: 37 20 ppm, 'Fi ll ,$!! jE, 7.6 4.6 ,F) 0> *m&!! *. i , !;!, g: :'1= 1d:$87Jj!RT*t3 a&> T,*L ', i j , jS$ . 1 >1 tg '}:*t 't; :: *t 1Q
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l;!L 8: b , >!. + P >! !t%!= J: 6 !!87J, \@>1;?4!!!Cj!q Lt!;t, 10 ~ 40 ppm Oti llB tld: * /::-;;t L i!: i!1 'j ,;, *Lt ,.i::\* it, C. !ftlyt 1 1d: .. t* L t, t! 1 ftE@) . '1 1"E ~; ,:f>1*'C'1, :;::v**t . 0{ @> 5'. ;< } , .;'ti:b ;, 7b o U v , 5'. ;!. } ., j6lji *lj$t " ;< F o>* " Ri5. i !i!; i !: , trjj j tE!CjN Ltld.@> ml<i'j& 0>{ ~F7!t g&b ,*LtV. 6.(3) *}j jili E{ i ;i 1!
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Ljjjs i ""' *t 80 A@> ;!. + P > ll! ,;$:i '@> i:*m tP3;?75* i:> .!!!t;;i!rrftll*t20 fF!;!L@>t;:!* 20 ,F*i i@)\ J: b i "J*!1* f :; i ;1 (MCV) 0> j T i!* g &> i , *'L ;t: !: *R f ' L ,Yuasa i;,"" 1d (n = 32. 1! i;;;it!j !;E 94.8 ppmJ;!T, 1 i!$!911;, 11.6 8.4 fj:) . Rfl. +ili ;, s J: Zi*liF, fl. *lll :0 , :*: MCV l T*5 J: 0'il!&!i lli; i ;{ti n }!E!! , ! !4, MA j l;E7!* 250 mg/! i;\J:@>i;ii 1;EIU il;lR;!,:, 1! i&1;El t 1 J:l}
i
! " ll* i:!lt; il @>*T;@:;::!!!i , i 1=1 rl, MA i j9: !: ;!g j*ljlj j::{tj !1* != 1t;j j :@)! !7jtjgab l;, *Lt: !: *tt' L t ,.. ,. : i:: Cherry i;, " ' 1, :, 70 A@> X + !,. >!
ti : ;' (1 t;;i!BftB 20 fpi;!T) 'Cl! ,%i EE7!tj i < i::t>i!=o*L, :iE, *lj ; , R, ll*jlf; O MCV @>j T7 tt2. "> !,*Li::!:*ft :;' L t ,.,>..
i
!!!. Seppalainen ;> " ' !t (n = 40, =jZ Jll!!, t;;i911"1 5 ,F) iE r!" li* , R\ j!j; , !P f!1'*111* , 11 +;*1!i;;;t Triebig !:, "" (n = ll, li! t;;i ! 92 ~ 114ppm, 5pt jl!! j :!;!Mq 4fj:), Murata , " ' (n = ii, 1! ,i;i liE ({1$ti:fi!i) 22 ppm. ,lZ Jl , 1;jUilllj 5fj;) 1d. iEll, t, ll iE t: i\!, fi'*!li;i;'C' MCV i, : j!!tjW:0> - ' *'L !: {j; iE
;*tti:75.0 i:: != fft't!f L 'C \ *, ,,! it 11*16f :!4i ;i9: (SCV) != ! L t !t, Rosen i;, " '
(n = 33, !!*,;;i 1;E 175 ppm !;t"' 1@ ";;iU11;1i 1 ~ 2j fj:),Cherry i;, "" , Murata ,;, " ' i!,, SCV @> f T i5t;2"> 1;> *'Li:: !: \&f!; L C V. Z,, Cherry i " ' !t i;> != SCV O>1 Tlt X + P >'1 t; !: !it1 :1 ;1!!!{ 7itz , Zi !: i *Rf!f L t \ * ,!,.~ ;b' Seppalainen i;, "" , Triebig i!> "" . Yuasa !;, 46ii$:1 * \0 SCV !,:*t !!tl !: jj : ;;7!{i::7i. o it: !: * j Lt , ,; ,.
Slower motor fibers" ' @>{ j j ;1 , !i jt ilt3;@>ii9 Jf!:iit (ampiitude) " ' !=jti j%j ,::*, jpt!t t:'4ii :;2 7i' ,7!. 0 i::.
J;!L !: &> 6 !: , 50 ppm *i!1;E@>Jb!i i1 { 8!j 1 :0>!. +P :, lU*,;;'C' MCV ,3 3: 0t SCV l. !j! 44i7i*;a&> i;, *'L .!i. L7!. L ,5:75* i;,, Yuasa i "" @> *j!j;;C'Jbl :ti f 1;E i' {, fitl;el, ;!%jj 75t g&b ,:, *'L 6 !> @) @>. n:tit ;::ljt, j*1 {jq@>ljEjj:1* ;!{E@> E: C ;;, : t:*jt L v,(4) 1i i
x + v 7 1! t != J: . , lii O ij #!! != 0 *. tSeppalainen i;, " ' 1* 96 AO l! t! :f;' ' 1;$111i= t!!?i L , !i:rl, MA j j9j tljj j!!: il:f;t\i:lC *, i' L 'C !1 i J*'iit\ 'C'{j, :!=
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iSi75' 0 i:: !: *ft{;; L /::. Harkonen i;, "" !;:, 98 A@>1!;!t;;
:Et !: 98 )\ 0*j!!!t; . :. ll:iji;: L /:: ** 1:1 it* 4}: : \ j ,*'i;;
O Ml != j!U i!!!lJ: a3b l:> i'L ti: *. o i::. Rosen i:, " ' jt , y ;g:.!, 1 t :;t!;t@> 3 0 0 TJ\Ol!; ,!;:!f' 33 A !: #j !!*t 6 A,j j- jj;&j lo>. j&! i;;: . i7 A i ! Jl:!j : L t:. j; *{ **: < !!;!t @>i: !. J: z, j j, \0>1* !!i. id; ij::;j *t .&> i;,*Lti:;!. o t:r < loy*t%1 t:'j j 0>1U !t ',>, llii[6]:5t35 i) , l 1=1 ti;t != :. i!* 0 ;t:;i:tHtllli; 1;ft;!'@>t! 1=i! i 5;!f ' {, fi'f;t'4' - ,!iti!;E7it i , 0 /::. Harkonen i;, " ' !,:, 1!jji! 41!*i*!R;tl:*rl. MA j&j;gi!t};j< ! rl" MAi E700 mg/!i T'C'1*1i, i 5 E. f;t ** lO%'Ct , Z, @> 1=*t L, 700 mg/1 :'iE!; . /:: > 0> t 30 % !: i! i !il!'iit*t!1, i;, *'L i:: !: *Rf ' U t:. C@>i&1 1d: 30 ppm ' 8 1*ftlli!;!i;; L t: 'f;'lC+il;!t' ' 6 !: tne f L /::. Matikainen , " ' !;:, 99 A O> X + P > li!; tR::i3'('F Jl ,;$i&!;E 29.5 ppm, qZt ll *!;!U1111 12.8fF) != lLt, **m*:lli :;1 ;,: : ii:liti!%* f . t ,*, itt i j;zto:t!i il 1;'@ il ,;;i!* ! !:"F Jf jti, *}.:$ V . . !: i ';j L 7!:. : t:,* j . 0*ij9 : ;6{1:jtl=j j ,; jlt;i ,.*
(5) 1aitt*lllfi 1;fii Murata i:, " ' !t:, . + p > 1!! j%: jll A !: *j!!t! U A :'
Jbi!;! L. ,L, f'!ilZI R-R !Hll 0> :un!ild:1 t!$\t:'j T Lt, *t:*' ,C. }1 t;kl. !;t! . 1;> *'L ;g:*. o t: !: *ftf! L 'C V .. ,.4.3 \ i *Aj IARC *s J: Ci*>j 1 1 EPA != J: . ' !: , C *'L :'C'@> X .f. P, i: j%j . , i;: *ji ;g: *R{!;7!. i:, !,:, i, F 'eo> x + u > 1 *j !: 75tA, !: @> 1;1j!C 1!!1 !!;5*85 . , !: ,i~ ,!, 0> it <;1 igJ i:: !: L 'C L .'65, . 51
Matanoski i;, " ' 1*, j;;.! .'A:Li\. C'1!!i < X + P > ~7' ' :-'.:. > 1Q*t { ;,$t*t@);;E ;:Wf3 75* ;,, .\ :. M;, j'1. tlll!,U >' /*1 1111i, .&; Cl'li > / <lM@>56 i; !: X + P :, 1!!*, 1;1. 1tl!Ui!!*ttt> o it:!: *j!j!; Lt*s O : /:: Bond 57i , ;!. + L, ,>'i!! , i;{ ; '0> i:ili!i4i;, U > /*lm, &CN i; iim ;ft*1&i5{A,
*:jjlJ: b > j7!*0 t: !: *Ej!; Lt v. ,. -JjC *'L ,;, @>*R{ !: !;ti !!. , >:. + L, > 1 ,!;: '@>i im;{14i&*{A.!= J: Z, ,Ei=!; !a:, iVlj*j J: b t, ,*t;:7, '. 0 t: }: v . ;i *!tf ,; > . , 58-61iott , 62i j, :, ;< + p ;, ,je u ? - tlflfiX!;!!=i 1, ':'.>,
2.904 45 0>{'p : "C'1* , U >' /{' 1:1111L\i @> 5 4i:!; 7, t!giJljL t V *it: !: *Rf!; L 'C \ *.>, 7!t C. @>4 1ii;;8:@>tW"jl ;1!! ,;;i! IH! ', 1 3!; 1, iP !: 1, :j!Ui!!!7!tti: < i;, 1= x + u > j :;g.O>;!! . !M!;;1. ,k ; ,#Et!; jd, . ;j - F ::jE{ @>;j:jl!{ J: b4> ,!>;::75* 0 /::. Mejnhardt i;, " ' 1, ;, i. h!: ='A !!!
\i 'i X .f. P ? - 7 $ ' >:. r. >! i;;;: ' (5p j2 ppni, 1 i*;i!!$1 12 ppm t:'1 J 33 fF X + U >'loy 3i;) != o v. tl:11111* @> (4'il::'C'1, :;:: ,*) iWm*t!1, i;, *'L, X + P > - 7$, :.:=r. >. yF lt;;!S . ' 1;, <
i
Eintn{{1*!!7!'A, }: 1%1{ L. t , * , , }:!E t \* Z, ify' MaLanoski l;, " ' ' Macaluso i;, "' 1, :,X + P > - 7' ' :,::E. >'1! , : 't g&> ,:, *'L t>, j ljll, jj\64 0)U X 1*, 7' :-:, r. :, ll ii !=1 i!! L, ;< + b >'1! ,;; }:!*4i :;G:1!!1
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&!1* t .&> i;, it i: *'.? 7:: !: , . ') *tt'; ' L C \ *.>,. i;:/:: Hodgson i;> " ' lt. 662 AO X + P > { Ot;'0> 5 *;, @>U >')<llt != J: : , yEi=;1 '*t 3 A!t, !Uli li!!0) 0.6 A J: b {>i*i7>. 0 /:: !: *R;!i L t v * : ,;fy< 1 *;;t1 +9; !: U :, / *ljjj!= J: . ,
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:5. ti:t ;brr7!g Z&b l:, *'Lt:*t C @>* jjU l*jF: f": !=; ' :t:'j, :tj: < , 7t:\11;!75'A, i;!#f@>V. '*'*LO*tA. !. OV. 'C t>, l=:*:7!'!@1f 'liR "k O {>: '; :1=tR;lyU L /:: l> @> ld:,::75*0 t: *: *Rj j, *'Ltv. 6 co'. lARCOX+ u >, = *- } 6?. rs)(1930, F** i 1990, j: tl. , >!, + V > 7 X 7" v ' L;;gl= 1 ,Fi;!L"Zb*'L/:: 35.067 A@>9;'$C ;'tii: '*t !) != J:6, !:, 5Ei=s$;*,, jjj;jtA, , .L. !i:j:E7jtA. , * , '- >
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;:, v . ,) > , *lm. ,k ,S, &El=:*: ,,;t;' :ti:t irU !,: Z&> , *L, :: *'
o /=7it, ! ! nn. ;l ' ,} >' )*1!i@> ,) X ' @>t U!t 2. ,t) 1;, *'Li::*L*' L ,9:75'151! ,$ftbel 1 f 1, :3?.&> 1 *t; i5'0 t:!: *R ' *LCV. 6,."t ?i;! !; t13:, >Kl lNational Cancer Tnstitute 75t * 1:l
4 : - 7:' Fischer 344 v F != 500 : /:: 1* 1000mg/kg/day, B6C3F, '7 ,> X 1= 150 : /:: 1* 300mg/kg/day @>i&1;EO X + U > !tE E !=*>it: 0 'C4 :--i- L
i::* ;j , >!. + L. . >'lC l* gg l*jl:: ;&7i*A, j!tl;t 3g. &> 1 *Lt, 75. o
i:: !: *&j . L t v, 6, 69}. L jfy, L tj, 7j* G,, 600 ppm, 6hours/day, 5 days/week O X+ L-
. >" ' 18~ 20 *. i$ 1!!t.7. . 'rt:"t v L 'c'id:, ?Ll;!M04 :7!**1ilin Lt: !: *&f ' *ct ,. 6 " '. g: i:: Sprague-Dawley ' v F != , 52i 1"l25, 50, 100, 200, 300 ppm @>X + U > 3;:'1!&.. 7* *t't:* , !j ;j@;;;039, j= atjt* jjn u ,::7!., t: 71) *t m{!$ * ;aj: !: !jgj!E$Ll!$j kia:t jj" L jt: " !: @>*&j .*t: ,,S,.i;!LO l= F . U, atb!j 'C@>*Rf 7!. i , 7, +
. P > @>- 7itA,{! j=. 0\*'C ; ; ;SR '!! t'! 2B. *< 'C >;s ;).
4.4 itt{ -; . 1 *sg: 0* : !1 1 x+ P >.! 3*:{ ;;: .@>*tl U >,/* !;;;:fg{* '@>t yn
l='?V. 'C!,: . < *&{ j- *Le, ;s b " ~"8', Meretoja , " '80) !,:, i j{1:7j? X+ v ' 9 i iT. 1;9@> 1~ 140 ppm O>:.-?. u > != ,$ *Lt: 26 A@>9;1!t@>**i U >'?{31t@> lO~
26%'C';!" !,{*j94 '*S5 . Lt, a b , ** !!t @> 1~ 4 % t:tb;! Lt*i:9:1=i1 7!. 0 i: : *1t Ltv*, ,. 1, i!. L;&: *f>7i, ;;t7jt 9:v. 7!:&>E l~ 0;t!j +, E '- 08 j !3;
*EL, ..!Jb49 ! 'Cid:, h :$R . 5 {*; ; (SCE) id:, 7. +. u
>, j!!jgg j!: :!a:{ jl:, != != ; j: . , !: *&{ - *. Lt ,. .", 81).
L?!* L ;9:7, tl5 , E } t:'lt 33 ~ 70 ppm @>, , 3:{ ;;::R" 16A"i, 6~ 58 ppm Oll ,${ ;j ': '24 Aco', *;- } Ti;9{ ':::: ' 18 A"', : i: i{b7 ;? X + v ' ii,.:*R'C'0>X.f. V >..!! ' ${ ;! ': . 70 A " ) @) jj u > /*: g @> j ;&:<i'SCE l*:?,. t>*L*:7b. o t: !:!;a i. S *Ltv. . ,.3!i{1:7' X 5" v ' T 'C'liti < 22 A@> X?" P >'1 t$ '
@> !;,, ii d, MA + PGA i!$1$:**159 mg/g. cr i;!LOi6jiE51;E, ,$S\:'C, Fj rla{ j! ft : 7 )1,7 : > adduct L, '<,p : 0> j!W j= j j, ;7jtj .&b , *t. jt:.!: @>*R{ . 7j*a;,;S, 86i. t, ,,j - j* 9g jj :Ei;R'@j < 48 : @> X + P ;,! ,9 . (Rti x'7" V >i 1;!: 64.3 mg/m') <i' {>, ;!.+ P ;.'!9'i8::!*:!: 7iV7 > adduct b, ':)V : Ollarl= ld;lngi!E7it 2"> , *'Li::;b*,\ . D l:: > adduct P '<)P !: 0> 11a !: i*1 i! , 5'3 a&> G, *'L,::7, .0 7!: : *&f ' *'Lt, *Z, 87).4,5 $E. ;;E, $:'
Zielhuis , " @> ,!4 U . . X . . iL. jijj .:;< 5'. 1, . > 1!; , 8;{ ;!
:; ' 9 A@>flf $t:'1*, ;f7*'7fy*t:'85 6 75<$E. 4;E ln 7 1i >. @>!
b175t 2a5 G, *'Lit:. : ;t: Bergamaschi , "9' i* , 71 A Ox . . P 7 11 3${ ;!:" (EFi*ja;. rj. { aj!j j j 106
mg/g. cre) @>**1 im O C04 ' T 'J >.'/< 1:Ri:1, :*t ! 3\o> .*tt: Jl:,*<'CiiF,!* LCv*;S, C !: (C08 ' T U >'/*:bk tl;t *? i;,;:: \ .), NK *mfi . j;*L !c C056 *is J: Ut C016 75t J:
b - < 3 E !t Ltv*;S, c !:, jj j:E{j:@>,j jg;<i' ,.Z DR ,s J:
O*TL. 2R o;F !t7!*tjj"n LCv. t", C t:7!. G,, ;< + P >. 1! 3$l= ,k o 'C tHim. lt, @> U >'/* ;1:,}'7.1= v l* 0$ ."ji1= {1:7it,1= CC, *,Z !: *Rj . LtV. .6,. Li5* L;::*t ,, >:. 7'. P ;.. @>$&;; "i ;1:tl. 1 ~,6*& '1t ,*: < .@> t: C Z, *lWji, :*F L, *.4.6 t:;j"$ ' 0'*Fi : , Ex+ P >/ 1<'x = - >:. 1, - >. T; :t:!, Oil:, :L. 1 'C'
l!m < :<tt: 'm: ' 9.000 A@> 1 % iti! @> 1 '!d: 15.57 %t,l ji5;!{ 0> 7.98 %@>*!j2 j "C'tt) o t: '"" !: V . 5 *&; '75<i#>,6 . :i!:;!. + P >@>$itll. i!l! : 82 ppm @>!bi{b7 X+ v ' L*!;'@"i < tC E@>tUi Lt:! 0>{*"tlt, ** ! ;Cl @>. *L!:
tL!i '4'6 t: 4%1 7i, 0 ;t: (95%{ *iit :lUi - 7.7%~ +O. 6 %) !: $&f " t'ccv *.", " '. L z, . L ;::7i{ i;,. ;!. + P ? * , :75*,!<. @> !t: m ;j != ! L : v. !: v. ;j *& . {, 85.", 92.95i. d: t: ! L:; . 1= X + P > 1!! i;;0*i !;*7!*3;, 6, X * =.5" >. A*E&fr! 1.397 A, / ily ,> z. - A! *ji282 A04;t, l;:
fif3 'ci*, 5ba&.; fj;, .F. ? 'j, ql }!!*E, , g:t:i;tR:4 ! 0>* jjui*; a> G, *L;*:*. 0 /:: : $&f ' *Lc, .6, 96i.Muttj , " ' !*:, jjjjQ. ig o x+ u :, (8h-TWA t 130
ppm) !=!;;,%: L*:'*<' i$: ; T@>nn!Ri7. ' + > (PRL)
i!l1::1d*t , : '0> -&.*t, @> 2 f '1= l:: 0 t ,s b , nn. ! PRL i
!;E !:ii d. >!,+ P >.'{ i4 i "El=*Bl *t ab C, *tt:!: $R '
L 'cv*,S . 16 /\0',!:t!EX .7. P >'1!!j E$: ' (8h-TWA <:' 50ppm) }:, 16 A@>*t ' 'Onn. i PRLi 1:El. 1t ! !: A
. t:' 7!*jg. &b i *Ltj:7j*o i::ij* q ,$: '@>n jT {*0> PRL 5 '
*mla!,:1'p4}:M!*!j t* ,". E >'j ! * JV. >*lj *t . .
*Lt:i*; .!,:, *j' ; '@> .*t $: b j jl:1= bZl L, PRL j !j! tjto. :j*t9: j irn;j*. , i;, *. Lj:: !: @>*R j5t , 6, 98). c @>
16 A@>1! 3 $ '!= !d:;$E; , ! il i ,!* i laiUlo L*'Lte '*,$ . 15 *'Lt$3 b , C @> . !: **1 Arfinj ", 9" !*nn. !! j PRLi 1;!:@>t m : V * o z!:tiji*&lJq5j* . @> :{1:1d:, !1:;ier ! ' :'gl i . 1 il 1@>-01=tj: b 5 6 !: jj: t\*.",.J;!LO*&f . i;!#}ic , v* < 0*. x + u >1 3S !: 1:;i; .
Cl$, fj ! ! i! !: O j!q ig;!= o i, . t ;lg : : L *: *R *t , Z,**99~'0n', ! *gj@)X+ V :,'i&!;E*ti 15;:. -*L<V*tj: \* {, o7!t. . < d: i::;:.. 7. P > i;{#}@>{j: eq j. @>{ ! j=ov. C@>;B E*', ;F: ** j5j!=oV*t@>;!t q75t;j<+5j. t:o t: b 't6t:&>, 7!.+ 1, . >1! 38:!= J: , !1:;i ii91!E . CK3E; j j. 0, *C*i ;i ' .6, @> lJ:ftE L , *.! !E*<illtil. j;q L'C l*:, v, < 07i, , 1 Lt:* 75t*Rf '
*LtV. .", 75t = *'L l;, @>;ler:*:*>l! 3$ mii*tj: *Ltv. : ly*O@>'C'3j' jm*t*jE L " * 96. 105~i07j.
;< .7. P > . 1! 38 Lt:9;, 0*i '.; ,!*4i; ,, *iey'i'. !* '@>
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