jai mata di the mechanism for defocus-driven occular growth
DESCRIPTION
Jai Mata Di The Mechanism for Defocus-driven Occular Growth. The Eye. www.ahaf.org. Lens . Power ( Diopters )focal length (metres) 1 D 1 m 2 D.5 m Convex lens (has a positive power e.g +1.5 D) focal point forms convergent light - PowerPoint PPT PresentationTRANSCRIPT
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Jai Mata Di The Mechanism for Defocus-driven Occular
Growth
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The Eye
www.ahaf.org
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Power (Diopters) focal length (metres)
1 D 1 m2 D .5 m
Convex lens (has a positive power e.g +1.5 D) focal point forms convergent light
Concave lens (has negative power e.g -2D) focal point is traced back from diverging light
Lens
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http://www.math.ubc.ca/~cass/courses/m309-01a/chu/MirrorsLenses/lenses.htm
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Lens Accommodation
http://www.sapdesignguild.org/editions/highlight_articles_01/images/accomodation.png
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Emmetropia (normal vision)
Myopia (short sightedness)Corrected with negative power lens
Hyperopia ( Longsightness) Corrected with positive power glasses
Presbyopia (age-related changes)Range of accommodation depletion
Multifocal or bifocal lens correction
Disorders of optics of eye
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Visual Abnormalities
http://www.merckmanuals.com/professional/sec09/ch099/ch099a.html
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Retina/RPE/Choroid
http://www.maculacenter.com/LightBox/glossaryImages/rpe.jpg
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Crucial for the maintenance of photoreceptor excitability
The main functions of the RPE are the following: (1) Transport of nutrients, ions, and water (2) absorption of light and protection against
photooxidation, (3) reisomerization of all-trans-retinal into 11-cis-retinal,
which is a key element of the visual cycle, (4) phagocytosis of shed photoreceptor membranes, and (5) secretion of various essential factors for the
structural integrity of the retina.
Retinal Pigment Epithelium
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SUPER PROJECTNernst – Artificial Membrane
Diffusion of Ions Is there a transport of water?
Stepper Motor – Servo System Pusing in and pushing out fluid
Voltage Clamp Using fixed voltage and determining how much to change to
determine a transmission response
Fluid Flow Voltage Clamp Chamber
Artificial Membrane
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Usual method is to have a 2 mm diameter hole in teflon sheet between aqueous solutions. Place 1 drop of (say) phospholipid in dodecane on hole and allow it to thin (as one would a soap bubble). Eventually get an optically black lipid bilayer film.
Artificial Membranes: How they are made?
Why use Artificial Membranes?Calibration
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‘Nernst’
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‘Puddle’Stepper Motor – Servo SystemPushing in and pushing out fluid
SensorEngineered by David
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‘Stepper’
Engineered by David
Stepper Motor – Servo SystemPusing in and pushing out fluid
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‘Puddle 2’ - also using an artificial membrane
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RC-50 Imaging Ussing Chamber