january december 2010 - sunnybrook hospitalkristin harris (in clinic 2005 – 2006), medical...

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Rapid Response Radiotherapy Program (RRRP)

And Bone Metastases Site Group Clinic (BMC)

Annual Report

January–December 2010

Dr. Edward Chow Chair

Ms. Lori Holden Vice-Chair

Rapid Response Radiotherapy Program and Bone Metastases Site Group

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Executive Summary

On behalf of the Rapid Response Radiotherapy Program and the Bone Metastases Site Group

(RRRP/BMC), we are pleased to send you our 2010 annual report.

1. Clinics a) RRRP clinics: The number of patients seen annually in the five weekly half-day clinics

has reached a plateau of 500-600, eighty percent of which are new to OCC.

b) We have an advanced practice radiation therapist with the support of the Ministry of

Health (MOH).

2. Education a) Newsletter - Our readers indicated they found our quarterly newsletter HOT SPOT

informative and educational.

b) We continue to offer electives to palliative health care professionals from all over the

world to visit our Centre and learn about our programs.

c) We have a full time RRRP fellow

3. Research a) We were successful in obtaining grant support both from peer reviewed granting

agencies and industries to continue our research projects.

b) The publications and presentations from our members continue to be outstanding.

We have published 2 books titled: 1) Bone and Brain Metastases: Advances in

Research and Treatment and 2) Advanced Cancer. Pain and Quality of Life c) Research students from Waterloo‘s co-op program have been extremely productive,

have also won numerous awards and have been successfully accepted to medical

schools and graduate degrees

4. Awards Ms. Gunita Mitera (RRRP Therapist in clinic 2008 – 2010)

2010 University of Toronto PhD Scholarship for 5 years

Ms. Lori Holden (RRRP/BMC Vice-Chair and RRRP Advanced Practice Radiation

Therapist)

2010 Schulich Award for Nursing & Clinical Excellence

Dr. Edward Chow

2010 Outstanding Leadership Award, Ontario Palliative Care Association

2010 Best Annual Research Performance Award, Department of Radiation Oncology,

University of Toronto

Dr. Andrea Donovan

2010 Career Development Award, Department of Medical Imaging, University of Toronto

2010 E.L. Lansdown Award for Best Teacher in Residency Program, Department of

Medical Imaging, University of Toronto

2010 Outstanding Teacher in the Residency Program Award, Department Medical

Imaging, University of Toronto

2010 Dean‘s Fund New Staff Award, University of Toronto

2010 American Roentgen Ray Society Clinician Educator Development Program

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2010 Outstanding Poster Award (2nd place), 2010 Canadian Association of Radiologists

Meeting

Poster title: ―Hip Arthroplasty Hardware and Complications‖

Dr. Urban Emmenegger

2010 Prostate Cancer Canada (PCC) Clinician-Scientist Award

2010 Canadian Cancer Society Research Institute (CCSRI) Junior Grant Panel Travel

Award

Ontario Institute for Cancer Research (OICR) Clinician-Scientist II Investigator Award

Dr. Arjun Sahgal

2010 Postgraduate Mentorship Award, Department of Radiation Oncology, University of

Toronto

Dr. May Tsao

2010 Excellence in Post-graduate Medical Education, Department of Radiation Oncology,

University of Toronto

5. Our Quality Assurance rounds resulted in several published case reports.

This report summarizes our very successful year and the academic activities of the RRRP/BMC.

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Odette Cancer Centre Rapid Response Radiotherapy Program (RRRP)

2010

The membership of the RRRP currently includes:

Radiation Oncologists

Edward Chow (Chair)

Toni Barnes

Cyril Danjoux

Arjun Sahgal

May Tsao

Kristopher Dennis (Fellow)

Radiation Therapists

Lori Holden (Vice-Chair)

Florencia Jon

Nurses

Matina Floros

Maryon Walter

Ernest Dixon

Michelle Ross

Jennifer Smith

Pharmacists

Carlo DeAngelis

Mark Pasetka

Medical Physicist

Gordon Chan

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Odette Cancer Centre Bone Metastases Site Group

2010

The membership of the BMC currently includes:

Radiation Oncologists Radiation Therapists

Edward Chow (Chair) Lori Holden (Vice-Chair)

Toni Barnes Florencia Jon

Cyril Danjoux

Arjun Sahgal Nurses

May Tsao Macey Farhadian

Kristopher Dennis (Fellow) Sima Farhangi-Manesh

Orthopedic Surgeons Pharmacists

Joel Finkelstein Carlo DeAngelis

Michael Ford Mark Pasetka

Albert Yee

Medical Physicist

Radiologists Gordon Chan

Monique Christakis

Andrea Donovan

Linda Probyn

Robyn Pugash

Joel Rubenstein

Medical Oncologist

Urban Emmenegger

Palliative Care Physician

Paolo Mazzotta

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EDUCATION

The RRRP publishes a quarterly newsletter ―HOT SPOT‖ and provides educational electives for

students and health care professionals interested in palliative radiotherapy.

Hot Spot Newsletter

In response to a satisfaction survey from our referring physicians who wanted better

communication, we initiated a quarterly newsletter in 1999 called ―HOT SPOT‖.

HOT SPOT is the educational newsletter of the RRRP at OCC. It is published quarterly and

distributed to oncologists, palliative care specialists, family doctors and professional health care

workers in palliative medicine. Our readership has expanded to over 2,000 per issue and we

continue to expand our circulation to new readers. Survey results from our readers rated the

educational value of HOT SPOT as high and suggested that we add other topics of interest. We

increased the content of our newsletter from four to six pages with additional sections and

contributors. The newsletter has regular articles on the following topics:

ETHICS

RESEARCH

PSYCHOSOCIAL

ADVICE FROM PHARMACIST

EDUCATIONAL ACTIVITIES

EDUCATIONAL INSERT

Each issue also has a double-sided educational insert.

The Editorial Board of Hot Spot

Founders Drs. L. Andersson and C. Danjoux

Editor Dr. E. Chow

Associate Editor Dr. C. Danjoux

Consultant Dr. S. Wong

Advisers Dr. E. Barnes, Dr. R. Goldman, Dr. A. Husain, Dr. L. Librach,

Ms. F. Jon, Dr. A. Sahgal, Ms. L. Holden, Dr. E. Szumacher,

Dr. M. Tsao

Editorial & Financial Manager Ms. S. Yuen

The publication of the newsletter is made possible by the financial support of pharmaceutical &

radiotherapy equipment companies.

The newsletter is also available electronically on the OCC web site:

http://www.sunnybrook.ca/content/?page=2341.

[Appendix E provides the content of previous issues and inserts of HOT SPOT from

1999-2010.]

http://www.sunnybrook.ca/content/?page=2341

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Educational Electives

As part of our undergraduate teaching, students from the co-op program at the University of

Waterloo have their electives working with the RRRP-BMC. This co-operative educational elective has

been extremely successful.

Awards

Philiz Goh (in clinic 2006 - 2008), nursing graduate student.

2010 Lippincott Williams & Wilkins (LWW) Nursing Poster Presentation Award

2010 University of Toronto Faculty of Nursing Gordon Cressy Student Leadership Award

2010 University of Toronto Student‘s Administrative Council Undergraduate Grant

2010 Clinical Practice and Education Poster Presentation Award, 16th International

Conference on Cancer Nursing

2010 Education Award for Nursing Student, Nursing Leadership Network of Ontario

2010 Johnson & Johnson National Leadership Award

Candi Flynn (in clinic 2007 – 2008)

2010 Have A Heart Bursary Program Award, Canadian Cardiovascular Society Academy

Stephanie Hadi (in clinic 2007 - 2008), undergraduate student.

2010 Ontario Graduate Scholarship

Kristin Harris (in clinic 2005 – 2006), medical student.

2010 Mary L. Cassidy Award, University of Toronto Faculty of Medicine

Sarah Campos (in clinic 2008), undergraduate student.

2010 ‗Proudly She Marched‘ Jocelyn Cowan Scholarship, University of Waterloo

Nadia Salvo (in clinic 2008 - 2009), graduate student.

2010 Ontario Graduate Scholarship

[Appendix F – Undergraduate Teaching–Co-op Program]

Health Care Professionals Electives

The RRRP provides an orientation for other health care professionals to experience the activities of

the RRRP clinics. Drs. Angela van Baardwijk from the Netherlands and Professor Ben Corn from Israel

spent a couple of days with us as they plan to start a similar project in their Centre. Other visitors

include: Ms. Krista McGrath and Ms. Susan Loveland (radiation therapists) from Credit Valley (Carlo

Fidani) Centre, Mississauga, Ontario. They found the experience valuable and recommend it for

others planning to start a similar program.

Medical student observers: Drs. Tali Bogler, Amy Glicksman, Punam Rana, Michele Leigh, Daniel

Toguri, Meagan Doyle, Nafisha Lalani, Kedar Patil

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RESEARCH

The RRRP/BMC team objective is to provide palliative radiotherapy in an academic environment.

We participate in local, national and international clinical trials, have regular research rounds and

have been successful in securing grants to fund our research projects.

Clinical Trials

We participate in several clinical trials. The research students have been an essential resource in

helping us to enroll, follow-up, analyze and publish our studies. Without the dedication of our

research students, it would have been difficult to successfully complete our research studies.

[Appendix G - A list of ongoing research studies in the RRRP and BMC]

CPROG (Canadian Palliative Radiation Oncology Group)

Our collaboration with Princess Margaret Hospital (PMH) and the Hamilton Regional Cancer Centre

Palliation Radiation Oncology Group, led to the formation of the Palliative Radiotherapy Oncology

Group Ontario (PROG-O) in 2000. Since then PROG-O has expanded to include Cancer Centres

from the Maritimes, Manitoba, Calgary and British Columbia. Currently, this group meets monthly

through videoconference. This has improved communication between the staff involved in the

palliative radiotherapy program in those Centres and offered the opportunity for collaboration in

research. At the last CARO meeting, more Cancer Centres expressed enthusiasm in participating in

PROG-O rounds.

PROG-O offers a national forum for monthly research discussion in palliative radiotherapy. Over the

past years the coordinators for the PROG-O rounds have been Drs. J. Wu, A. Bezjak, R. Wong and

T. Barnes. The rounds are scheduled for the first Tuesday of every month.

To represent the change in participation from Ontario to Cancer Centres across Canada we

renamed the group as Canadian Palliative Radiation Oncology Group (CPROG)

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Videoconference Rounds (CPROG)

The subjects discussed during 2010 were:

2010 Title Presenter(s)

January 12 Impact of 2D vs 3D radiotherapy planning for patients

with bone metastases – A prospective study

Dr. Kathy Pope, PMH

February 2 Improving functional outcomes with dose-escalated

irradiation for malignant spinal cord compression

Dr. Siddhartha Baxi,

PMH

March 2 Development of a quality of life (QOL) module for

malignant spinal cord compression (MSCC): Four phases

to international validation

Ms. Gunita Mitera,

OCC

April 13 Palliative radiation therapy and the C.S.R.T in the

Capital

Ms. Sharon Seed,

Ottawa

May 4 a) Neuropathic pain: The case of a critical statistical

error detected by a manuscript reviewer

b) Complicated or uncomplicated bone pain? A look at

bone metastases morphology using routine CT

imaging

a) Dr. Jackson Wu,

TBCC Calgary

b) Dr. Melanie

Gaudreault, TBCC

Calgary

June 1 Palliative treatment of painful bone metastases with MRI

guided high intensity focused ultrasound (MRIgFUS)

Drs. Sangeet Ghai

and Walter

Kucharczyk, UHN

October 5 Test connection session

Dr. Rebecca Wong,

PMH

November 23 Statins – Do they have a role in the management of

radiation late effects and, by extension, retreatments?

Dr. Wilfred Levin,

PMH

December 21 Case reports a) Dr. Jackson Wu,

TBCC Calgary

b) Dr. Rebecca

Wong, PMH

*Rounds cancelled: July 6, August 3, September 7

RRRP and BMC Monthly Meetings

The subjects discussed during 2010 were:

2010 Title Presenter(s)

January 5 Research Projects

(Chaired by Dr. Edward Chow)

Dr. Edward Chow

January 19 RRRP Quality Assurance Round

(Chaired by Dr. May Tsao)

Ms. Shaelyn Culleton,

Mr. Liang Zeng, Dr.

Gordon Chan

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February 2 RRRP Presentation – A needs assessment of the Rapid

Response Radiotherapy Program for patients receiving

palliative therapy and their caregivers

(Chaired by Ms. Gunita Mitera)

Dr. Shahmeer Ansari

February 16 Research/Education Round – Study proposal: Dose

escalation for malignant spinal cord compression


Dr. Siddhartha Baxi

March 2 RRRP Presentation – Results of 2 RRRP Studies

(Chaired by Ms. Lori Holden)

Ms. Gunita Mitera

April 6 RRRP Presentation – Abstract presentations for the

upcoming palliative conference


Ms. Gunita Mitera,

Ms. Shaelyn Culleton,

Mr. Liang Zeng,

Mr. Martin Leung,

Drs. Amanda Caissie

and Eman Al-Duhaiby

May 4 RRRP Presentation – Update on the development of the

EORTC bone, brain and SCC modules

(Chaired by Ms. Florencia Jon)

Ms. Lori Holden

May 18 RRRP Quality Assurance Round


Ms. Florencia Jon,

Mr. Justin Kwong,

Ms. Cassandra Uy,

Mr. Martin Leung

June 1 RRRP Presentation – Radiotherapy at MAASTRO clinic,

the Netherlands


Dr. Angela van

Baardwijk

July 6 RRRP Presentation – Palliative radiation oncology as an

evolving subspecialty; from DNR to basic science


Dr. Amanda Caissie

July 20 RRRP Presentation – Skeletal care in cancer


Dr. Benjamin Ofori

August 3 RRRP Presentation – Oxygen Therapy: How is it

ordered, funded, and provided for in the community


Ms. Dianne Naiman

September 7 RRRP Presentation – Prevention and management of

constipation in cancer patients


Dr. Carlo DeAngelis

September 21 RRRP Presentation – Breakthrough cancer pain – A

thorn by any other name would hurt as much


Dr. Carlo DeAngelis

October 5 RRRP/BMC Annual General Meeting


All

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October 19 RRRP Quality Assurance Round


Drs. Urban

Emmenegger and

Kristopher Dennis

November 2 RRRP Research Meeting – Discuss research projects on

home oxygen therapy, SOB and LC 13, fatigue and lung

patient preference study


Ms. Kaitlin Koo and

Mr. Liang Zeng

November 16 Research/Education Round – Home oxygen therapy


Ms. Kaitlin Koo and

Mr. Liang Zeng

December 7 RRRP Presentation – a) Magnetic resonance-guided high

intensity focused ultrasound for palliation of

painful skeletal metastases - A pilot study

b) Cementoplasty presentation


a) Drs. Gregory

Czarnota and

Kristopher Dennis

b) Dr. Robyn Pugash

*Rounds cancelled: March 16, April 20, June 15, August 17, December 21

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Grants "Bone Tape": Development of a novel method for stabilizing traumatic craniofacial injuries.

Congressionally Directed Medical Research Program $144,300 (2010 - 2011). Whyne CM,

Fialkov J, Regev E, Santerre P.

A phase I trial on the use of PDT in the treatment of breast cancer vertebral metastasis.

Canadian Breast Cancer Foundation $300,850 (2009 – 2012). Yee A, Whyne C, Akens M,

Sahgal A, Chow E, Wilson B, Bisland S, Clemons M.

A phase II study of maintenance therapy with Temsirolimus in androgen-independent

prostate cancer after first-line chemotherapy with Docetaxel. Wyeth Pharmaceuticals Canada

Inc. $315,000 (2007 – present). Emmenegger U.

A pilot study to evaluate urinary markers of pain flare in patients undergoing external beam

radiotherapy for the treatment of painful bone metastases. International Society of Oncology

Pharmacy Practitioners. $15,000 Euros (2010). DeAngelis C, Chow E, Pasetka M, Walker S.

Bone stability and tumor burden in the metastatic spine: implications of variable disease

patterns. Canadian Institute of Health Research $379,862 (2008 - 2012). Whyne C, Yee AJ,

Finkelstein JA.

Centre for Research in Image-Guided Therapeutics. Canada Foundation for Innovation,

Research Hospital Fund Large Scale Institutional Endeavours $14,337,919 (2008 - 2011).

Hynynen, K, multiple collaborators including Whyne C.

Development of a Canadian-led international bone metastases module to accompany

European Organization for Research and Treatment of Cancer Quality of Life Group Core

Questionnaire (the EORTC QLQ-C30) for future clinical trials in patients with bone metastases.

Phase IV study. EORTC Quality of Life Group Grant $74,000 Euro (2010). Chow E.

Enhancing the application of health-related quality of life evaluations for guiding clinical care:

An Examination of changes in appraisal in lumbar degenerative disease patients before and

after surgical intervention. PSI Foundation $59,000 (2009 - 2011). Finkelstein J.

Finite Element Modelling of The Human Craniofacial Skeleton. Advanced cranio-maxillofacial

forum research grant $60,000 (2009 - 2011). Fialkov J, Whyne CM.

Hypoxia: a mediator of PSA surge in prostate cancer patients undergoing antiangiogenic

therapy? University of Toronto Dean‘s Fund. $10,000 (2009 – 2014). Emmenegger U.

Improving emergent care for bone health in vertebral disease - knowledge translation

through ethnographic study of access, triage, and care delivery. Canadian Institute of Health

Research: Catalyst Grant in Bone Health. $10,000 (2010 - 2011). Webster F, Yee AJ,

Fehlings MG, Kreder HK, Gagliardi A.

Metastatic breast cancer genome anatomy. Canadian Breast Cancer Research Alliance,

Special Competition in New Approaches to Metastatic Disease in Breast Cancer Research

$750,000 (2005 - 2010). Seth A, Aubin J, Kahn H, Lyons-Weiler J, Yee AJ, Narod S.

Metronomic chemotherapy in castration-resistant prostate cancer: Overcoming treatment

resistance. Prostate Cancer Canada $300.000 (2010 – 2012). Emmenegger U.

Modeling thin bone structures of the human skeleton. Natural Sciences and Engineering

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Research Council (NSERC) $165,000 (2006 - 2011). Whyne C.

Photodynamic therapy treatment to enhance fracture healing. Congressionally Directed

Medical Research Program $144,300 (2010 - 2011). Akens MK, Whyne CM, Nam D, Wilson

BC, Yee AJM.

Photodynamic therapy treatment to enhance fracture healing. US Army Department of

Defense DOD Peer Reviewed Orthopaedic Research Program, Research Program of the

Congressionally Directed Medical Research Programs (CDMRP). $100,000 (2010 - 2011).

Akens M, Whyne C, Yee A, Nam D, Wilson B.

Studying the role of macro-autophagy in mediating response to antiangiogenic tumor

therapy. Canada Foundation for Innovation Leaders Opportunity Fund. $90,000 (2010).

Emmenegger U.

The impact of photodynamic therapy for the biomechanical stability of the metastatic spine:

characterization independent and combined treatment effects with bisphosphonates and

radiation therapy. Ontario Institute for Cancer Research $530,361 (2008 - 2011). Whyne C,

Yee AJ, Wilson BC, Burch S, Bisland S.

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Publications Akens MK, Hardisty MR, Wilson BC, Schwock J, Whyne CM, Burch S, Yee AJ. Defining the

therapeutic window of vertebral photodynamic therapy in a murine pre-clinical model of

breast cancer metastasis using the photosensitizer BPD-MA (Verteporfin). Breast Cancer

Research and Treatment 119: 325-333, 2010.

Al Duhaiby E, Pang J, Kwok S, Chow E. Predictive models for survival in patients with

advanced cancer. The Asia-Pacific Journal of Oncology & Hematology (APJOH) (published

online January 2, 2010).

Amemiya Y, Wang W, Benatar T, Nofech-Mozes S, Yee AJ, Kahn H, Holloway C, Seth A.

Insulin like growth factor binding protein-7 reduces growth of human breast cancer cells and

xenografted tumors. Breast Cancer Research and Treatment (published online May 13,

2010).

Barnes EA, Chow E, Tsao M, Bradley NM, Doyle M, Li K, Lam K, Danjoux C. Physician's

expectation of treatment outcomes for patients with brain metastases referred for whole

brain radiotherapy. International Journal of Radiation Oncology, Biology and Physics 76(1):

187-192, 2010.

Bedi H, Hird A, Campos S, Chow E. Symptom Clusters in Metastatic Cancer - A Critical

Appraisal. Journal of Pain Management 3(1): 17-30, 2010.

Bedi H, Kwong J, Chow E. Metastatic cancer: Symptom cluster and gender differences

research in patients with metastatic cancer. Journal of Alternative Medicine Research 2(3):

285-295, 2010.

Bedi H, Presutti R, Hird A, Campos S, Zhang L, Mitera G, Sinclair E, Barnes E, Tsao M, Sahgal

A, Danjoux C, DeAngelis C, Chow E. Gender difference in the Edmonton Symptom

Assessment System (ESAS) scores in patients with advanced cancer. Journal of Pain

Management 3(1): 63-72, 2010.

Campos S, Zhang L, Salvo N, Hird A, Tsao M, Barnes E, Danjoux C, Sahgal A, Mitera G,

Sinclair E, Nguyen J, Napolskikh J, Chow E. Elderly patients with painful bone metastases

should be offered palliative radiotherapy. International Journal of Radiation Oncology, Biology

and Physics 76(5): 1500-1506, 2010.

Campos S, Zhang L, Sinclair E, Tsao M, Barnes E, Danjoux C, Sahgal A, Goh P, Culleton S,

Mitera G, Chow E. The palliative performance scale: Examining its correlation to Karnofsky

Performance Scale in an outpatient palliative radiation oncology clinic. Journal of Pain

Management 3(1): 89-97, 2010.

Chow E, Hruby G, Harris K, Enright K, Sinclair E, Chan G. Determining the accuracy of health

care professionals in predicting the survival of patients with advanced metastatic cancer.

Journal of Pain Management 3(1): 73-80, 2010.

Chow E, James J, Barsevick A, Hartsell W, Ratcliffe S, Scarantino C, Ivker R, Roach M, Suh J,

Petersen I, Konski A, Demas W, Bruner D. Functional interference clusters in cancer patients

with bone metastases: A secondary analysis of RTOG 9714. International Journal of Radiation

Oncology, Biology and Physics 76(5): 1507-1511, 2010.

Chow E, Schofeld P, Rosenbluth R, Merrick J. Advanced cancer and pain. Journal of Pain

Management 3(1): 3, 2010.

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Culleton S, Kwok S, Chow E. Radiotherapy for pain. Clinical Oncology (published online

December 17, 2010).

D‘Alimonte L, Sinclair E, Seed S. Orthovoltage energies for palliative care in the 21st century:

Is there a need? Radiography (published on October 13, 2010).

Dennis K, Wong K, Jon F, Kwong J, Chow E. Benign myelomalacia mimicking malignant spinal

cord compression in a patient with metastatic non-small cell lung carcinoma: A case report.

International Journal on Disability and Human Development 9(1): 77–79, 2010.

Donovan A, Rosenberg ZS, Cavalcanti CF. MR imaging of peripheral entrapment neuropathies,

Part II: The knee, leg, ankle and foot. RadioGraphics Radiographics 30(4): 1001-1019, 2010.

Donovan A, Rosenberg ZS. Current concepts in MR imaging of ankle and lateral hindfoot

impingement syndromes. American Journal of Roentgenology 195(3): 595-604, 2010.

Donovan A. Radiology residents as teachers: Current status of teaching skills training in US

residency programs. Academic Radiology 17(7): 928-933, 2010.

Finkelstein JA, Razmjou H, Schwartz CE. Response shift outcome assessment in orthopaedic

surgery: is there a difference between complete and partial treatment? Journal of Clinical

Epidemiology 62(11): 1189-90, 2010.

Hardisty MR, Akens M, Yee AJ, Whyne CM. Image registration demonstrates the growth plate

has a variable affect on vertebral strain. Annals of Biomedical Engineering 38(9): 2948-2955,

2010.

Hird A, Culleton S, Chow E. Cancer-related bone pain. Editor: Andrew Davis. Oxford

University Press. European Journal of Cancer Care 19 (4): e7, 2010.

Hird A, Wong J, Zhang L, Tsao M, Barnes E, Danjoux C, Chow E. Exploration of symptoms

clusters within cancer patients with brain metastases using the Spitzer Quality of Life Index.

Supportive Care in Cancer 18(3): 335-342, 2010.

Hojjat SP, Hardisty MR, Whyne CM. Micro CT based highly-automated 3D segmentation of the

rat spine for quantitative analysis of metastatic disease. Journal of Neurosurgery: Spine

13(3): 367-370, 2010.

Hrabchak C, Rouleau J, Moss I, Woodhouse K, Akens M, Bellingham C, Keeley F, Yee AJ.

Evaluation of genipin cross-linked elastin-like polypeptides in the treatment of osteochongral

defects of the knee in rabbits. Acta Biomaterialia 6(6): 2108-2115, 2010.

James T, Holden L, Laura D‘Alimonte L. A retrospective review of the effect of foot

immobilization on isocentre shifts for the treatment of prostate cancer. Canadian Journal of

Medical Radiation Technology 41(1): 20-24, 2010.

Johnson C, Fitzsimmons D, Gilbert J, Arrarras JI, Hammerlid E, Bredart A, Ozmen M,

Dilektasli E, Coolbrandt A, Kenis C, Young T, Chow E, Venkitaraman R, Howse F, George S,

O‘Connor S, Yadegarfar G on behalf of the EORTC Quality of Life Group. Development of the

European Organisation for Research and Treatment of Cancer quality of life questionnaire

module for older people with cancer: The EORTC QLQ-ELD15. European Journal of Cancer 46:

2242-2252, 2010.

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Joseph K, Tai P, Wu J, Barnes E, Levin W. Workshop report: a practical approach and

general principles of re-irradiation for in-field cancer recurrence. Clinical Oncology (published

online September 29, 2010).

Khoury A, Beyth S, Mosheiff R, Joskowicz L, Finkelstein J, Liebergall M. Computer-assisted

orthopaedic fracture reduction: clinical evaluation of a software prototype. Current

Orthopaedic Practice (published online October 26, 2010).

Lo S, Holden L, Lutz S, Liu R, Chow E. Should all patients with uncomplicated bone

metastases be treated with a single 8 Gy fraction? Expert Review of Pharmacoeconomics &

Outcomes Research 10 (2): 95-98, 2010.

Lo SS, Sahgal A, Wang JZ, Mayr NA, Sloan AE, Mendel E, Chang E. Stereotactic body

radiotherapy for spine metastases. Discovery Medicine 9(47): 289-296, 2010.

Lotan R, Al-Rashdi A, Yee A, Finkelstein J. Clinical features of conjoined lumbosacral nerve

roots versus lumbar intervertebral disc herniations. European Spine Journal 19(7): 1094-

1098, 2010.

Lubovsky O, Wright D, Hardisty M, KissA, Dreder HJ, Whyne C. Importance of the dome and

posterior wall as evidenced by bone density mapping in the acetabulum. Clinical

Biomechanics (published online November 24, 2010).

Lutz S, Korytko T, Nguyen J, Khan L, Chow E, Corn B. Palliative radiotherapy: When is it

worth it and when is it not? The Cancer Journal: The Journal of Principles & Practice of

Oncology 16 (5): 473-482, 2010.

Lutz S, Lo S, Chow E, Sahgal A, Hoskin P. Radiotherapy for metastatic bone disease: Current

standards and future prospectus. Expert Review of Anticancer Therapy 10(5): 683-695, 2010.

Ma L, Sahgal A, Chuang C, Descovich M, Petti P, Smith V, Verhey L, Barbaro N, McDermott M,

Huang K, Nakamura J, Sneed P, Larson D. Functional relationship between the volume of a

near-target peripheral isodose line and its isodose value for gamma knife radiosurgery.

Radiosurgery 7: 75-83, 2010.

Ma L, Sahgal A, Cozzi L, Chang E, Shiu A, Letourneau D, Yin F, Fogliata A, Kaissl W, Hyde D,

Laperriere NJ, Shrieve DC, Larson DA. Apparatus-dependent differences in spine stereotactic

body radiotherapy (SBRT) dosimetry. Technology in Cancer Research and Treatment 9(6):

563-574, 2010.

Ma L, Sahgal A, Descovich M, Cho Y, Chuang C, Huang K, Laperriere N, Shrieve D, Larson D.

Equivalence in dose fall-off for isocentric and non-isocentric intracranial treatment modalities

and its impact on dose fractionations schemes. International Journal of Radiation Oncology,

Biology and Physics 76(3): 943-948, 2010.

Ma L, Sahgal A, Larson D. Letter to the editor. Technology in Cancer Research and Treatment

9(4): 317, 2010.

Maloul A, Fialkov J, Hojjat SP, Whyne CM. A technique for the quantification of the 3D

connectivity of thin articulations in bony sutures. Journal of Biomechanics 43: 1227-1230,

2010.

Mitera G, Chan G, Mah K, Law R, DeAngelis C, Dent R, Chow E. A rare adverse skin reaction

after a single 8Gy of radiation therapy to the thoracic spine: A case report and review of the

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literature. Current Oncology 17(5): 70-73, 2010.

Mitera G, Fairchild A, DeAngelis C, Emmenegger U, Zurawel-Balaura L, Zhang L, Bezjak A,

Levin W, Mclean M, Zeiadin N, Pang J, Nguyen J, Sinclair E, Chow E, Wong R. A multi-centre

assessment of the adequacy of cancer pain treatment using the Pain Management Index.

Journal of Palliative Medicine 13(5): 589-593, 2010.

Mitera G, Fairchild A. Cancer pain and under-medication. Journal of Alternative Medicine

Research 2(3): 345-355, 2010.

Mitera G, Probyn L, Ford M, Donovan A, Rubenstein J, Finkelstein J, Christakis M, Zhang L,

Campos S, Culleton S, Nguyen J, Sahgal A, Barnes E, Tsao M, Danjoux C, Holden L, Yee A,

Khan L, Chow E. Correlation of computed tomography imaging features with pain response in

patients with spine metastases after radiation therapy. International Journal of Radiation

Oncology, Biology and Physics (published online October 1, 2010).

Mitera G, Zeiadin N, Kirou-Mauro A, DeAngelis C, Wong J, Sanjeevan T, Sinclair E,

Danjoux C, Barnes E, Tsao M, Sahgal A, Chow E. Retrospective assessment of cancer pain

management in an outpatient palliative radiotherapy clinic using the pain management

index. Journal of Pain and Symptom Management 39(2): 259-267, 2010.

Mitera G, Zeiadin N, Sahgal A, Finkelstein J, Chow E, Loblaw A. Quality of life measures used

in radiation therapy trials for patients with metastatic spinal cord compression (MSCC): A

literature review. Journal of Pain Management 3(1): 31-38, 2010.

Myers J, Gardiner K, Harris K, Lilien T, Bennett M, Chow E, Selby D, Zhang L. Evaluating

correlation and inter-rater reliability for four performance scales in the palliative care setting.

Journal of Pain and Symptom Management 39(2): 250-258, 2010.

Nguyen J, Sahgal A, Chow E, Danielson B. Brain metastases and quality of life. Journal of

Alternative Medicine Research 2(3): 257-272, 2010.

Olsen M, Davis ET, Whyne CM, Zdero R, Schemitsch EH. The biomechanical consequence of

insufficient femoral component lateralization and exposed cancellous bone in hip resurfacing

arthroplasty. Journal of Biomedical Engineering 132: 081011, 2010.

Pang J, Panzarella T, Chow E. Prognosis and survival prediction. Journal of Alternative

Medicine Research 2(3): 309-332, 2010.

Peleg E, Beek M, Joskowicz L, Liebergall M, Mosheiff R, Whyne CM. Patient specific

quantitative analysis of fracture fixation in the proximal femur implementing principal strain

ratios. Method and experimental validation. Journal of Biomechanics 43(14): 2684-2688,

2010.

Presutti R, Zhang L, Tsao M, Barnes E, Danjoux C, Sahgal A, Mitera G, Sinclair E, Chow E.

Projected referral for health care services in an out-patient palliative radiotherapy clinic.

Journal of Pain Management 3(1): 81-88, 2010.

Roberge D, Menard C, Bauman G, Chan A, Mulroy L, Sahgal A, Malone S, McKenzie M,

Schroeder G, Fortin M, Ebacher A, Milosevic M. Radiosurgery scope of practice in Canada: A

report of the Canadian association of radiation oncology (CARO) advisory committee.

Radiotherapy and Oncology 95(1): 122-128, 2010.

Ruschin M, Nayebi N, Carlsson P, Tamerou M, Li W, Laperriere N, Sahgal A, Menard C, Jaffray

18

D. Performance of a novel repositioning head frame for gamma knife perfexion and image

guided linac-based intracranial stereotactic radiotherapy. International Journal of Radiation

Oncology, Biology and Physics 78(1): 306-313, 2010.

Sahgal A, Barani IJ, Novotny J, Zhang B, Petti P, Larson DA, Ma L. Prescription dose

guidelines based on physical criterion for multiple metastatic brain tumors treated with

stereotactic radiosurgery (SRS). International Journal of Radiation Oncology, Biology and

Physics 78(2):605-608, 2010.

Sahgal A, Chow E, Holden L, Merrick J. Understanding the patient. Journal of Alternative

Medicine Research 2(3): 253, 2010.

Sahgal A, Larson D. In reply to Lo et al. International Journal of Radiation Oncology, Biology

and Physics 78(1): 314, 2010.

Sahgal A, Ma L, Chuang C, Hossain S, Petti P, Larson D, Shrieve D. Comparisons of novalis

and cyberknife spinal stereotactic body radiotherapy treatment planning based on physical

and biologic modeling parameters. Radiosurgery 7: 366-377, 2010.

Sahgal A, Ma L, Gibbs I, Gerszten PC, Ryu S, Soltys S, Weinberg V, Wong S, Chang E, Fowler

J, Larson DA. Spinal cord tolerance for stereotactic body radiotherapy. International Journal

of Radiation Oncology, Biology and Physics 77(2): 548-553, 2010.

Sahgal A, Ma L, Weinberg V, Gibbs IC, Chao S, Chang U, Werner-wasik M, Angelov A, Chang

EL, Sohn MJ, Soltys S., Letourneau D, Ryu S, Gerszten PC, Fowler J, Wong CS, Larson DA.

Re-treatment spinal cord tolerance for spine stereotactic body radiotherapy. International

Journal of Radiation Oncology, Biology and Physics (published online October 18, 2010).

Salvo N, Barnes E, van Draanen J, Stacey E, Mitera G, Breen D, Giotis A, Czarnota G, Pang J,

De Angelis C. Prophylaxis and management of acute radiation-induced skin reactions: A

systemic review of the literature. Current Oncology 17(4) 94-112, 2010.

Sanghera P, Perry J, Sahgal A, Symons S, Aviv R, Morrison M, Lam K, Davey P, Tsao M.

Definition and significance of pseudoprogression following radiotherapy with concurrent

temozolomide for glioblastoma multiforme. Canadian Journal of Neuroscience 37(1): 36-42,

2010.

Satoh T, Kobayashi K, Hori T, Iida S, Sato A, Ishiguro H, Chow E, Shimozuma K. The

European Organisation for Research and Treatment of Cancer (EORTC) Quality of Life

Questionnaire for Japanese patients with bone metastases—The Japanese version of the

EORTC QLQ-BM22. Gan To Kagaku Ryoho 37(8): 1507-1512, 2010. (Japanese)

Sdezowski T, Whyne CM, Fialkov J. Towards characterization of craniofacial biomechanics.

Journal of Craniofacial Surgery 21: 202-207, 2010.

Selby D, Cascella A, Gardiner K, Do R, Moravan V, Myers J, Chow E. A single set of numerical

cutpoints to define moderate and severe symptoms for the Edmonton Symptom Assessment

System (ESAS). Journal of Pain and Symptom Management 39(2): 241-249, 2010.

Shiue K, Sahgal A, Chow E, Lutz S, Chang E, Mayr N, Wang J, Cavaliere R, Mendel E, Lo S.

The management of spinal cord compression from spinal metastases. Expert Review

Anticancer Therapy 10(5): 697-708, 2010.

Sigal IA, Whyne CM. Mesh morphing and response surface analysis: Quantifying sensitivity of

19

vertebral mechanical behaviour. Annals of Biomedical Engineering 38: 41-56, 2010.

Szumacher E, Barnes E. Palliative care: Patient understanding, preference and physician

communication. Journal of Alternative Medicine Research 2(3): 297-308, 2010.

Won E, Akens MK, Hardisty M, Burch S, Bisland S, Yee AJ, Wilson BC, Whyne C. Effects of

photodynamic therapy on the structural integrity of vertebral bone. Spine 35(3): 272-277,

2010.

Won E, Wise-Milestone L, Akens MK, Burch S, Yee AJ, Wilson BC, Whyne CM. Beyond

bisphosphonates: Photodynamic therapy structurally augments metastatically involved

vertebrae and destroys tumor tissue. Breast Cancer Research and Treatment 124(1): 111-

119, 2010.

Wong NS, Buckman R, Clemons M, Verma S, Dent S, Trudeau M, Roche K, Ebos J, Kerbel R,

DeBoer G, Sutherland D, Emmenegger U, Slingerland J, Gardner S, Pritchard K. Phase I-II

trial of metronomic chemotherapy with daily dalteparin and cyclophosphamide, twice weekly

methotrexate and daily prednisone (DalCMP) as therapy for metastatic breast cancer using

soluble vascular endothelial growth factor receptor levels as markers of response. Journal of

Clinical Oncology 28(5): 723-730, 2010.

20

In Press Ahn H, Singh J, Nathens A, Macdonald R, Travers A, Tallon JM, Fehlings M, Yee AJ. Pre-

Hospital Care Management of a Potential Spinal Cord Injured Patient: A Systematic Review

of the Literature and Evidence Based Guidelines. Journal of Neurotrauma.

Akens MA, Sahgal A, Yee AJ. Evaluation of photodynamic therapy as treatment for spinal

metastases. Journal of Pain Management.

Ali Zahrai, Jaskarndip Chahal, Dan Stojimirovic, Emil H. Schemitsch, Albert Yee, William

Kraemer. Quality of life and educational benefit among orthopedic surgery residents: A

prospective, multicentre comparison of the night float and the standard call systems.

Canadian Journal of Surgery.

Ang Lee, Peng Chun, Deng Zhaoqun, Sze Shan, Cheng Y, Shatseva Tatiana, Yee AJ, Du

Weidong, Yang J, Yang BB. MicroRNA miR-93 promotes tumor growth and angiogenesis by

targeting integrin beta 8. Oncogene.

Bederman SS, Murnaghan O, Lansang E, Malempati H, Johnston E, Wilkinson M, Bronstein Y,

Finkelstein JA, Yee AJ. In-hospital mortality and surgical utilization in severely

polytraumatized patients with and without spinal injury. Journal of Trauma.

Bederman SS, Omoto D, Yee AJ, Kreder HJ, Finkelstein JA. How do validated measures of

functional outcome compare with commonly used outcomes in administrative database

research for lumbar spinal surgery. European Spine Journal.

Bjarnason G, Pirouzmand F, Bilbao J, Danjoux C, Sahgal A, Mitera G. Pre-operative

stereotactic body radiotherapy to a skull renal cell metastasis: An alternative to pre-operative

embolization? Journal of Palliative Medicine.

Chan E, Jon F, Holden L, Dennis K, Chow E. Pathological fracture of the tibia in a patient with

invasive ductal carcinoma of the breast: A case report of a rare finding. Journal of Pain

Management.

Cho Y, Zhang B, Bernstein M, Sahgal A. Brain metastases: gamma knife technology for

radiosurgery. Journal of Pain Management.

Choo C, Mamedov A, Chung M, Choo R, Kiss A, Danjoux C. Vitamin D insufficiency is common

in non-metastatic prostate cancer patients. Nutrition Research.

Chow E, James J, Barsevick A, Hartsell W, Ratcliffe S, Scarantino C, Ivker R, Suh J, Petersen

I, Konski A, Demas W, Bruner D. Confirmatory factor analysis of Brief Pain Inventory (BPI)

functional interference clusters in patients with bone metastases. Journal of Pain

Management.

Culleton S, Dennis K, Koo K, Zhang L, Zeng L, Kwong J, Nguyen J, Jon F, Holden L, Barnes E,

Tsao M, Danjoux C, Sahgal A, Chow E. Correlation of the Palliative Performance Scale with

the Karnofsky Performance Status in an outpatient palliative radiotherapy clinic. Journal of

Pain Management.

Culleton S, Kwok S, Chow E. Conventional radiation treatment and bone metastases. Journal

of Pain Management.

Dahele M, Fehlings M, Sahgal A. Stereotactic body radiotherapy: an emerging treatment for

patients with spinal metastases. Canadian Journal of Neuroscience.

21

Du WW, Yang BB, Shatseva TA, Yang BL, Deng Z, Shan SW, Lee DY, Seth A, Yee AJ. Versican

G3 promotes mouse mammary tumor cell growth, migration, and metastasis by influencing

EGF receptor signaling. PLoS ONE.

Emmenegger U, Francia G, Chow A, Man S, Kerbel RS. Tumors that acquire resistance to low-

dose metronomic cyclophosphamide retain sensitivity to maximum tolerated dose

cyclophosphamide. Neoplasia.

Foote M, Letourneau D, Hyde D, Massicotte E, Rampersaud R, Fehlings M, Fisher C, Lewis S,

La Macchia N, Yu E, Laperriere N, Sahgal A. Stereotactic body radiotherapy for spine

metastases: technical details for practice. Journal of Clinical Neuroscience.

Jon F, Nguyen J, Rubenstein J, Holden L, Ross M, Mitera G, Dennis K, Chow E. Painful sacral

insufficiency fracture simulating metastatic disease from primary breast cancer. Journal of

Pain Management.

Kwong J, Jon F, Holden L, Zeng L, Culleton S, Danjoux X, Tsao M, Barnes T, Sahgal A, Dennis

K, Chow E. Dedicated out-patient palliative radiation treatment clinics for patients with

advanced cancer. Journal of Pain Management.

Kwong J, Jon F, Sugar L, O‘Hayon B, Holden L, Nguyen J, Ross M, Uy C, Khan L, Dennis K,

Chow E. Renal mass – primary or metastatic? The search for a definitive diagnosis. Journal of

Pain Management.

Lee DY, Jeyapalan Z, Fang L, Yang J, Zhang Y, Yee AJ, Li M, Du WW, Shatseva T, Yang BB.

Expression of Versican 3'-untranslated region modulates endogenous microRNA functions.

PLoS ONE.

Leung M, Nguyen J, Rubenstein J, Chow E, Holden L, Dennis K, Jon F. Asymptomatic 20cm-

long femoral metastasis. A unique case of long-bone disease responding to radiotherapy

alone. Journal of Pain Management.

Lutz S, Berk L, Chang E, Chow E, Hahn C, Hoskin P, Howell D, Konski A, Kachnic L, Lo S,

Sahgal A, Silverman L, von Gunten C, Mendel E, Vassil A, Bruner D, Hartsell W. Palliative

Radiotherapy for Bone Metastases: An ASTRO Evidence-Based Guideline. International

Journal of Radiation Oncology, Biology and Physics.

Ma L, Petti P, Wang B, Descovich M, Chuang C, Barani IJ, Kunwar S, Shrieve DC, Sahgal A,

Larson DA. Apparatus-dependent normal brain tissue dose with stereotactic radiosurgery of

multiple brain metastases. Journal of Neurosurgery.

Moss I, Gordon L, Woodhouse K, Whyne CM, Yee AJ. A novel thiol-modified-hyaluronan and

elastin-like polypeptide composite material for tissue engineering of the nucleus pulposus of

the intervertebral disc. Spine.

Nguyen J, Chow E, Zeng L, Zhang L, Culleton S, Holden L, Mitera G, Tsao M, Barnes E,

Danjoux C, Sahgal A. Palliative response and functional interference outcomes using the brief

pain inventory for spinal bony metastases treated with conventional radiotherapy. Clinical

Oncology.

Nguyen J, Hayter C, Wong R, Danjoux C, Holden L. A survey to assess patient awareness and

interest in hypnosis for cancer pain and distressing procedures. Journal of Alternative

Medicine Research.

22

Nguyen J, Sahgal A, Sinclair E, Mitera G, Farhadian M, Danjoux C, Finkelstein J, Yee A, Ford

M, Pugash R, Emmenegger U, Chakraborty A, Chow E. Rapid Response Radiotherapy

Program and Multidisciplinary Bone Metastases Clinic. Journal of Pain Management.

Podolsky D, Martin A, Whyne CM, Massicote E, Hardisty MR, Ginsberg H. Exploring the role of

3D simulation in surgical training: Feedback from a pilot study. Journal of Spinal Disorders &

Techniques.

Presutti R, Hird A, DeAngelis C, Fairchild A, Holt T, Loblaw A, Chow E. Palliative radiotherapy

of bone metastases and pain flare. Journal of Pain Management.

Presutti R, Nguyen J, Hird A, Fairchild A, Clemons M, Kerba M, Sahgal A, Chow E. Bone

metastases and quality of life. Journal of Pain Management.

Presutti R, Nguyen J, Holden L, DeAngelis C, Culleton S, Mitera G, Tsao M, Barnes E, Danjoux

C, Sahgal A, Salvo N, Khan L, Chow E. Radiation-induced nausea and vomiting in a palliative

radiotherapy clinic: a preliminary analysis. Journal of Pain Management.

Sahgal A, Bilsky M, Chang EL, Ma L, Yamada Y, Rhines L, Letourneau D, Foote M, Yu E,

Larson DA, Fehling M. Stereotactic body radiotherapy for spinal metastases: current status

with a focus on the application to the post-operative patient. Journal of Neurosurgery Spine.

Sahgal A, Chow E, Holden L, Merrick J. Bone metastases. Journal of Pain Management.

Sahgal A, Chow E, Holden L, Merrick J. Brain metastases. Journal of Pain Management.

Sahgal A, Massicotte E, Rampersaud R, Yee A, Fehlings M, Lewis S, Letourneau D, Hyde D,

Larson D, Ma L. Stereotactic body radiotherapy for spine tumors. Journal of Pain

Management.

Sahgal A. Spinal cord tolerance to radiation. Journal of Pain Management.

Salvo N, Doble B, Khan L, Amirthevasar G, Dennis K, Pasetka M, DeAngelis C, Tsao M, Chow

E. Prophylaxis of radiation-induced nausea and vomiting using 5-HT3 serotonin receptor

antagonists: a systematic review of randomized trials. International Journal of Radiation

Oncology, Biology and Physics.

Soliman H, Bezjak A, Sahgal A, Tsao M. Treatment of brain metastases: striving to improve

patient outcomes.

Szwedowski TD, Fialkov F, Whyne CM. Sensitivity analysis of a validated subject-specific finite

element model of the human craniofacial skeleton. Proceedings of the Institution of

Mechanical, Part H. Engineers Journal of Engineering in Medicine.

Thind AS, Strauss BH, Teitelbaum AA, Karshaffian R, Ladouceur M, Whyne CM, Goertz DE,

Foster S. A Novel Method for Measurement of Proximal Fibrous Cap Puncture Force in Chronic

Total Occlusions: The Effect of Increasing Age. Catherterization and Cardiovascular

Interventions.

Uy C, Jon F, Rosewell C, O‘Hayon B, Hanna S, Bjarnason G, Holden L, Nguyen J, Ross M,

Kwong J, Sahgal A, Khan L, Dennis K, Chow E. Suspicious perianal lesion in a patient with

renal cell carcinoma. Journal of Pain Management.

Whyne CM, Haridsty MR. Quantification of metastatic burden in the spine and its structural

implications. Journal of Pain Management.

23

Zeng L, Sahgal A, Zhang L, Koo K, Holden L, Jon F, Tsao M, Barnes E, Danjoux C, Dennis K,

Khan L, Chow E. Patterns of pain and functional improvement in patients with bone

metastases after conventional external beam radiotherapy and a telephone validation study.

Pain Research and Treatment.

Zeng L, Zhang L, Culleton S, Jon F, Holden L, Kwong J, Khan L, Tsao M, Danjoux C, Sahgal A,

Barnes E, Chow E. Edmonton Symptom Assessment Scale as a prognosticative indicator in

patients with advanced cancer. Journal of Palliative Medicine.

24

Books, Book Chapters Akens MA, Burch S, Yee AJ. Pre-clinical evaluation of photodynamic therapy as treatment for

spinal metastases. Bone and brain metastases: Advances in research and treatment. Pages

113-124. Editors: Arjun Sahgal, Edward Chow and Joav Merrick. Nova Science Publishers,

Inc. 2010.

Bedi H, Hird A, Campos S, Chow E. A critical discussion of symptom clusters in metastatic

cancer. Advanced cancer. Pain and quality of life. Chapter 12 Pages 129-144. Editors:

Edward Chow and Joav Merrick. Nova Science Publishers, Inc. 2010.

Bedi H, Kwong J, Chow E. Symptom cluster and gender differences research in patients with

metastatic cancer. Bone and brain metastases: Advances in research and treatment.

Chapter 24 Pages 357-371. Editors: Arjun Sahgal, Edward Chow and Joav Merrick. Nova

Science Publishers, Inc. 2010.

Bedi H, Presutti R, Hird A, Campos S, Zhang L, Mitera G, Sinclair E, Barnes E, Tsao M, Sahgal

A, Danjoux C, DeAngelis C, Chow E. Gender difference in patients with advanced cancer.

Advanced cancer. Pain and quality of life. Chapter 15 Pages 165-175. Editors: Edward

Chow and Joav Merrick. Nova Science Publishers, Inc. 2010.

Campos S, Zhang L, Chow E. Quality of life issues in patients with bone metastases.



Campos S, Zhang L, Sinclair E, Tsao M, Barnes E, Danjoux C, Sahgal A, Goh P, Culleton S,

Mitera G, Chow E. Utilization of performance scale in an outpatient palliative radiation

oncology clinic. Advanced cancer. Pain and quality of life. Chapter 18 Pages 201-212.

Editors: Edward Chow and Joav Merrick. Nova Science Publishers, Inc. 2010.

Cho YB, Zhang B, Bernstein M, Sahgal A. Gamma knife technology for radiosurgery of brain

metastasis. Bone and brain metastases: Advances in research and treatment. Pages 333-347.

Editors: Arjun Sahgal, Edward Chow and Joav Merrick. Nova Science Publishers, Inc. 2010.

Chow E, Hird A, Wong, R, Zhang L, Wu J, Barbera L, Tsao M, Barnes E, Danjoux C. Meaningful

change in pain scores in the treatment of bone metastases. Advanced cancer. Pain and

quality of life. Chapter 13 Pages 145-151. Editors: Edward Chow and Joav Merrick. Nova


Chow E, Hruby G, Harris K, Enright K, Sinclair E, Chan G. Is it possible to predict the survival

of patients with advanced metastatic cancer? Advanced cancer. Pain and quality of life.

Chapter 16 Pages 177-189. Editors: Edward Chow and Joav Merrick. Nova Science

Publishers, Inc. 2010.

Chow E, Khan L, Bruland O. Radiotherapy of skeletal metastases. ASBMR Primer 8th edition

of the primer on the metabolic bone diseases and disorders of mineral metabolism. American

Society for Bone and Mineral Research (accepted for publication).

Chow E, Tsao M, Sahgal A, Barnes E, Danjoux C, Mitera G, Sinclair E. Post procedure

radiation therapy after kyphoplasty or vertebroplasty/cementoplasty for bony metastatic

disease. Advanced cancer. Pain and quality of life. Chapter 10 Pages 119-120. Editors:


25

Culleton S, Hird A, Nguyen J, Emmenegger U, Verma S, Simmons C, Barnes E, Tsao M,

Sahgal A, Danjoux C, Mitera G, Sinclair E, Chow E. Bisphosphonates in combination with

radiotherapy for the treatment of bone metastases. Advanced cancer. Pain and quality of

life. Chapter 5 Pages 55-68. Editors: Edward Chow and Joav Merrick. Nova Science


Culleton S, Kwok S, Chow E. Conventional radiation treatment of bone metastases. Bone

and brain metastases: Advances in research and treatment. Chapter 2 Pages 27-39.


Culleton S, Pang J, Zhang L, Presutti R, Nguyen J, Mitera G, Sinclair E, Barnes E, Tsao M,

Danjoux C, Sahgal A, Chow E. Are baseline ESAS symptoms related to pain response in

patients treated with palliative radiotherapy for bone metastases? Advanced cancer. Pain

and quality of life. Chapter 6 Pages 69-76. Editors: Edward Chow and Joav Merrick. Nova


Culleton S, Zhang L, Sinclair E, Barnes E, Tsao M, Danjoux C, Campos S, Goh P, Chow E.

Improvement of symptoms following palliative radiation for bone metastases. Advanced

cancer. Pain and quality of life. Chapter 7 Pages 77-86. Editors: Edward Chow and Joav

Merrick. Nova Science Publishers, Inc. 2010.

Emmenegger U, Chow A, Bocci G. The biomodulatory capacities of low-dose metronomic

chemotherapy: complex modulation of the tumor microenvironment. The Tumor

microenvironment (TTME) Series. Pages 243-262. Editors: Reichle A. Springer-Verlag

GmbH. 2010.

Emmenegger U, Francia G, Shaked Y, Kerbel RS. Metronomic chemotherapy – principles and

lessons learnt from applications in the treatment of metastatic prostate cancer. Recent results

in cancer research. Pages 165-183. Editors: Berdel E, Kessler T, Liersch R. Springer-Verlag

GmbH. 2010.

Fairchild A, Chow E. Palliative radiotherapy. Cancer pain: assessment and management.

2nd edition. Pages 379-398. Editors: Eduardo Bruera and Russell Portenoy. Cambridge

University Press 2010.

Fairchild A, Hird A, Chow E. Pain control with palliative radiotherapy in bone metastases.

Recent advances in bone cancer progression and therapeutic approaches. Chapter 25 Pages

297-312. Editor: Dominique Heymann. Research Signpost 2010.

Flynn C, Clemons M, Zhang L, Chow E. The European Organization for Research and

Treatment of Cancer Quality-of-Life Group Bone Metastases Module (EORTC QLQ-BM22)

Questionnaire. Advanced cancer. Pain and quality of life. Chapter 20 Pages 225-232.


Hird A, Clemons M, Zhang L, Chow E. Skeletal related events in patients with metastatic

bone disease. Advanced cancer. Pain and quality of life. Chapter 11 Pages 123-127.


Hird A, Wong R, Flynn C, Hadi S, de Sa E, Zhang L, DeAngelis C, Chow E. Pain flare following

palliative radiotherapy for symptomatic bone metastases. Advanced cancer. Pain and quality

of life. Chapter 8 Pages 87-94. Editors: Edward Chow and Joav Merrick. Nova Science


26

Kwok S, Salvo N, Pang J, Chow E. Prognostic assessment of the cancer patient. Supportive

Oncology. Editors: Mellar P Davis, Petra Feyer, Petra Ortner, Camilla Zimmermann. Elsevier

(in press).

Lo SS, Sahgal A, Ma L, Chang EL. Advances in radiation therapy for brain metastases. Current

and future management of brain metastases. Editors: Kim and Lundsford. Karger (in press).

Lotan R, Finkelstein J. Minimally invasive surgical approaches for spine metastases. Bone and

brain metastases: Advances in research and treatment. Chapter 7 Pages 181-195. Editors:

Arjun Sahgal, Edward Chow and Joav Merrick. Nova Science Publishers, Inc. 2010.

Mitera G, Rubenstein J, Finkelstein J, Davidson M, Chow E. Remineralization of an impending

fracture from an osteolytic metastasis in a breast cancer patient from palliative radiotherapy

and bisphosphonate. A case report. Advanced cancer. Pain and quality of life. Chapter 26

Pages 287-294. Editors: Edward Chow and Joav Merrick. Nova Science Publishers, Inc.

2010.

Mitera G, Sahgal A, Laperriere N, Loblaw A. Management of malignant spinal cord

compression. Bone and brain metastases: Advances in research and treatment. Pages 55-69.


Mitera G, Zeiadin N, Sahgal A, Finkelstein J, Chow E, Loblaw A. Can we measure quality of

life for patients with metastatic spinal cord compression (MSCC)? Advanced cancer. Pain and



Nguyen J, Chung M, Ford M, Goh P, Rubenstein J, Sinclair E, Mitera G, Chow E. Surgical

stabilization of severely destructive upper cervical lytic bone metastases. Advanced cancer.

Pain and quality of life. Chapter 23 Pages 263-269. Editors: Edward Chow and Joav Merrick.

Nova Science Publishers, Inc. 2010.

Nguyen J, Leung M, Presutti R, Caporusso F, Holden L, Chow E. Position of appetite and

nausea in symptom clusters in palliative radiation therapy. Handbook of nutrition and diet

and in palliative care. Taylor & Francis Group (in press).

Nguyen J, Sahgal A, Chow E, Danielson B. Quality of life in brain metastases. Bone and

brain metastases: Advances in research and treatment. Chapter 16 Pages 217-237.


Nguyen J, Sahgal A, Sinclair E, Mitera G, Farhadian M, Danjoux C, Finkelstein J, Yee A, Ford

M, Pugash R, Emmenegger U, Chakraborty A, Chow E. Innovative palliative programs: Rapid

Response Radiotherapy Program and Multidisciplinary Bone Metastases Clinic. Bone and brain

metastases: Advances in research and treatment. Chapter 1 Pages 3-25. Editors: Arjun

Sahgal, Edward Chow and Joav Merrick. Nova Science Publishers, Inc. 2010.

Nguyen J, Sinclair E, Yee A, Finkelstein J, Ford M, Chakraborty A, Farhadian M, Pugash R,

Mitera G, Danjoux C, Barnes E, Tsao M, Sahgal A, Chow E. Multidisciplinary approach to

metastatic bone disease. Advanced cancer. Pain and quality of life. Chapter 14 Pages 153-

164. Editors: Edward Chow and Joav Merrick. Nova Science Publishers, Inc. 2010.

Pang J, Jenkinson R, Mitera G, Donovan A, Pugash R, Trudeau M, Quinton C, Sinclair E,

Nguyen J, Presutti R, Chow E. Cemented hemiarthroplasty, percutaneous acetabular

cementoplasty and post-operative radiation for a high risk lesion of the hip. Advanced

cancer. Pain and quality of life. Chapter 25 Pages 279-285. Editors: Edward Chow and Joav


27

Pang J, Panzarella T, Chow E. Survival predication. Bone and brain metastases: Advances in

research and treatment. Chapter 26 Pages 389-419. Editors: Arjun Sahgal, Edward Chow

and Joav Merrick. Nova Science Publishers, Inc. 2010.

Presutti R, Campos S, Finkelstein J, Rubenstein J, Sinclair E, Mitera G, Chow E. Simple

bracing for the relief of intractable pain. Advanced cancer. Pain and quality of life. Chapter

24 Pages 271-277. Editors: Edward Chow and Joav Merrick. Nova Science Publishers, Inc.

2010.

Presutti R, Hird A, DeAngelis C, Fairchild A, Holt T, Loblaw A, Chow E. Pain flare following

palliative radiotherapy of bone metastases. Bone and brain metastases: Advances in

research and treatment. Chapter 14 Pages 181-195. Editors: Arjun Sahgal, Edward Chow


Presutti R, Nguyen J, Hird A, Fairchild A, Clemons M, Kerba M, Sahgal A, Chow E. Quality of

life research in bone metastases. Bone and brain metastases: Advances in research and

treatment. Chapter 15 Pages 197-215. Editors: Arjun Sahgal, Edward Chow and Joav


Presutti R, Zhang L, Hird A, Deyell M, Chow E. Exploring the optimal definitions of partial

response and pain progression in patients receiving radiation treatment for painful bone

metastases. Advanced cancer. Pain and quality of life. Chapter 9 Pages 95-118. Editors:


Presutti R, Zhang L, Tsao M, Barnes E, Danjoux C, Sahgal A, Mitera G, Sinclair E, Chow E.

Projected referral for an out-patient palliative radiotherapy clinic. Advanced cancer. Pain and



Sahgal A, Massicotte E, Rampersaud R, Yee A, Fehlings M, Lewis S, Letourneau D, Hyde D,

Larson D, Ma L. Stereotactic body radiotherapy for spine tumors. Bone and brain metastases:

Advances in research and treatment. Pages 41-53. Editors: Arjun Sahgal, Edward Chow and

Joav Merrick. Nova Science Publishers, Inc. 2010.

Sahgal A, Soliman H, Larson DA. Whole brain radiotherapy of brain metastases. Current and

future management of brain metastases. Editors: Kim and Lundsford. Karger (in press).

Sahgal A, Wong CS, van der Kogel, A. Spinal cord. Radiation Injury. Pages 225-235. Editors:

Shrieve and Loeffler. Lippincott Williams and Wilkins 2010.

Sahgal, A. Clinical research in spinal cord tolerance to radiation. Bone and brain metastases:

Advances in research and treatment. Pages 135-141. Editors: Arjun Sahgal, Edward Chow


Soliman H, Bezjak A, Sahgal A, Tsao M. University of Toronto department of radiation

oncology research on the treatment of brain metastases: Striving to improve patient

outcomes. Bone and brain metastases: Advances in research and treatment. Pages 145-156.


Zhang L, Nguyen J, Hird A, Chow E. Bone metastases quality of life instrument tool.



28

Posters, Presentations and Published Abstracts

10th Annual Princess Margaret Hospital Conference. Toronto, Ontario, Canada,

October 28 - 30, 2010.

Caissie A, Nguyen J, Holden L, Sahgal A, Culleton S, Zhang L, Zeng L, Tsao M, Barnes E,

Danjoux C, Dennis K, Chow E. Palliative radiation for bone metastases not only relieves

pain but also improves quality of life.

Caissie A, Zhang L, Clemons M, Fairchild A, Kerba M, Vassiliou V, Nguyen J, Sahgal A,

Culleton S, Chow E. An international study of EORTC BM22 and C15 symptom/quality of

life scores showing association with radiation response of bone metastases.

Caissie A, Zhang L, Clemons M, Fairchild A, Kerba M, Vassiliou V, Nguyen J, Sahgal A,

Culleton S, Chow E. An international study of EORTC BM22 and C15 symptom/quality of

life scores showing association with radiation response of bone metastases.

Dennis K, Wong K, Nguyen J, Culleton S, Zhang L, Holden L, Jon F, Chow E. Palliative

radiotherapy for bone metastases in the last three months of life: Worthwhile or futile?

Koo K, Culleton S, Dennis K, Zhang L, Zeng L, Kwong J, Nguyen J, Jon F, Holden L,

Barnes E, Tsao M, Danjoux C, Sahgal A, Chow E. Gender difference in symptom

presentation among patients with bone metastases.

Koo K, Culleton S, Dennis K, Zhang L, Zeng L, Kwong J, Nguyen J, Jon F, Holden L,

Barnes E, Tsao M, Danjoux C, Sahgal A, Chow E. Correlation of the palliative

performance scale with the Karnofsky performance status in a Rapid Response Palliative

Radiotherapy Outpatient Clinic.

Koo K, Zeng L, Culleton S, Dennis K, Zhang L, Caissie A, Nguyen J, Holden L, Jon F,

Tsao M, Barnes E, Danjoux C, Sahgal A, Chow E. Do elderly patients with metastatic

cancer have worse quality of life?

Sahgal A. Spine Metastases.

Zeng L, Chow E, Zhang L, Culleton S, Holden L, Tsao M, Barnes E, Danjoux C, Sahgal A.

Comparison of pain response and functional interference outcomes between spinal and

non-spinal bone metastases treated with palliative radiotherapy.

Zeng L, Chow E, Zhang L, Culleton S, Holden L, Tsao M, Barnes E, Danjoux C, Sahgal A.

Analysis of pain and interference patterns with brief pain inventory in patients with bone

metastases: A confirmatory study.

Zeng L, Salvo N, Zhang L, Leung M, Khan L, Presutti R, Nguyen J, Holden L, Culleton S,

Chow E. Predictive factors for anxiety and depression in advanced cancer patients.

Zeng L, Zhang L, Culleton S, Jon F, Holden L, Kwong J, Khan L, Tsao M, Danjoux C,

Sahgal A, Barnes E, Chow E. Edmonton symptom assessment system as a

prognosticative indicator in patients with advanced cancer.

2010 Annual Hospice Palliative Care Conference. Toronto, Ontario, Canada, April

18 – 20, 2010.

Al-Duhaiby E, Pang J, Kwok S, Chow E. Predictive models of survival for patients with

advanced cancer.

Al-Duhaiby E, Pang J, Pasetka M, DeAngelis C, Chow E, Ko Y, Barnes E, Holden L, Mitera

G, Chung H. Evaluation of a daily diary for assessing the prevalence of radiation-induced

emesis (RIE): A pilot study in progress.

Caissie A, Presutti R, Nguyen J, Holden L, Sahgal A, Culleton S, Zhang L, Zeng L, Tsao

M, Barnes E, Danjoux C, Mitera M, Chow E. Response to palliative radiation of bone

metastases associated with improved BM22 and C15 symptom and quality of life scores.

Caissie A, Presutti R, Nguyen J, Holden L, Sahgal A, Culleton S, Zhang L, Zeng L, Tsao

M, Barnes E, Danjoux C, Mitera G, Chow E. Initial BN20 and C15 symptom and quality of

life scores in patients with brain metastases.

Chow E, Caissie A, Holden L. Radiation treatment of bone metastases – biased or

evidenced based.

29

Culleton S, Presutti R, Nguyen J, Holden L, DeAngelis C, Tsao M, Barnes E, Danjoux C,

Sahgal A, Chow E. Pattern of radiation-induced nausea and vomiting in a palliative

radiotherapy clinic.

Culleton S, Presutti R, Nguyen J, Pang J, Fairchild A, Mawani A, Clemons M, Kerba M,

Yee A, Zhang L, Sahgal A, Chow E. International cross-cultural field validation of an

EORTC questionnaire module for patients with bone metastases (EORTC QLQ-BM22): A

preliminary analysis.

Holden L, Nguyen J, Hayter C, Wong R, Danjoux C, Peltier J. A survey to assess patients‘

awareness and interest in hypnosis for cancer pain and distressing procedures.

Holden L, Nguyen J, Sinclair E, Yee A, Finkelstein J, Ford M, Chakraborty A, Farhadian M,

Pugash R, Mitera G, Danjoux C, Barnes E, Tsao M, Sahgal A, Chow E. A multidisciplinary

bone metastases clinic at Sunnybrook Odette Cancer Centre: A review of the experience

from 2006-2008.

Leung M, Presutti R, Nguyen J, Zhang L, Holden L, Mitera G, Culleton S, Chow E.

Assessing baseline quality of life in patients with bone metastases using the European

Organization for Research and Treatment of Cancer Bone Metastases Module (EORTC

QLQ-BM22).

Leung M, Salvo N, Zhang L, Presutti R, Nguyen J, Holden L, Culleton S, Zeng L, Chow E.

Predictive factors for anxiety and depression in patients with advanced cancer.

Mitera G, Probyn L, Ford M, Christakis M, Donovan A, Finkelstein J, Rubenstein J, Zhang

L, Campos S, Culleton S, Nguyen J, Sahgal A, Tsao M, Barnes E, Danjoux C, Holden L,

Yee A, Chow E. Pain relief for mechanical and tumour related factors from spinal

metastases: Can we predict who will respond to palliative radiotherapy?

Mitera G, Probyn L, Ford M, Donovan A, Rubenstein J, Finkelstein J, Christakis M, Zhang

L, Campos S, Culleton S, Nguyen J, Sahgal A, Barnes E, Tsao M, Danjoux C, Holden L,

Yee A, Khan L, Chow E. Correlation of computed tomography imaging features with pain

response in patients with spine metastases following radiation therapy.

Mitera G, Zhang L, Sahgal A, Barnes E, Tsao M, Danjoux C, Holden L, Chow E. A survey

of expectations & understanding of palliative radiotherapy from patients with advanced

cancer at the Rapid Response Radiotherapy Program.

Zeng L, Nguyen J, Danielson B, Presutti R, Pang J, Clemons M, Zhang L, Sahgal A,

Holden L, Mitera G, Chow E. International validation of the European Organization for

Research and Treatment of Cancer Brain Module (EORTC-QLQ-BN20+2) for Assessing

Quality of Life in patients with brain metastases – a preliminary analysis of Canadian

Centres.

Zeng L, Presutti R, Zhang L, Tsao M, Barnes E, Danjoux C, Sahgal A, Mitera G, Sinclair

E, Chow E. Projected referral for health care services in an out-patient palliative

radiotherapy clinic.

34th ASRT Radiation Therapy Conference. San Diego, California, USA, October 31 –

November 2, 2010.

Sinclair E. Minimally invasive treatment of tumour-related vertebral compression

fractures and other metastatic bone lesions.

American Society Therapeutic Radiation Oncology. San Diego, California, USA,

October 31 – November 4, 2010.




Jon F, Zeng L, Culleton S, Zhang L, Holden L, Tsao M, Barnes E, Sahgal A, Danjoux C,

Chow E. The Edmonton Symptom Assessment Scale (ESAS) as a prognostic indicator for

impending death in advanced cancer patients referred for palliative radiotherapy.

Khan L, Holden L, Zhang L, Culleton S, Zeng L, Jon F, Wong K, Danjoux C, Tsao M,

Sahgal A, Barnes E, Chow E. Prevalence of sleep disturbance in patients with bone

metastases attending an outpatient radiotherapy clinic.

30

Mitera G, Loblaw A, Sahgal A, Danielson B. Canadian-led international development of a

European organization for research and treatment of cancer quality of life module for

malignant spinal cord compression: results of phase I.

Pituskin E, Fairchild A, Chow E, Wu J, Presutti R, Gaudreault M, DeAngelis C, North S,

Kerba M, Venner P. Concurrent tyrosine kinase inhibitors and palliative radiotherapy in

the treatment of metastatic renal cell carcinoma: A retrospective database review.

Sahgal A, Ma L, Weinberg V, Gibbs I, Chao S, Chang U, Werner-wasik M, Fowler J, Wong

S, Larson D. Human spinal cord re-irradiation guidelines for stereotactic body

radiotherapy.

Canadian Association of Radiation Oncology Annual Meeting. Vancouver, British

Columbia, Canada, September 22 – September 25, 2010.

Caissie A, Holden L, Presutti R, Nguyen J, Culleton S, Sahgal A, Zhang L, Zeng L, Tsao

M, Barnes E, Danjoux C, Mitera G, Chow E. Symptom and quality of life post-

radiotherapy as assessed by BN20+2 and QLQ-C15-PAL in patients with brain

metastases.




Caissie A, Nguyen J, Sahgal A, Culleton S, Zhang L, Zeng L, Tsao M, Barnes E, Danjoux

C, Chow E. Bone metastases response to palliative radiation associated with improved

BM22 and C15 symptom and quality of life scores.

Khan L, Holden L, Zhang L, Culleton S. Zeng L, Jon F, Wong K, Danjoux C, Tsao M,

Sahgal A, Barnes E, Chow E. Prevalence of sleep disturbance in patients with bone

metastases attending an outpatient radiotherapy clinic.

Sahgal A, Ma L, Weinberg V, Gibbs I, Chao S, Chang U-K, Werner-wasik M, Angelov L,

Chang E. Re-irradiation spinal cord tolerance.

Canadian Orthopaedic Association Meeting. Edmonton, Alberta, Canada, June 20,

2010.

Malempati H, Kreder H, Wadey V, Massicotte E, Yee A. Spine Surgery Fellowship

Training: An evaluation of cognitive and technical competences.

Zahrai A, Chahal J, Stojimirovic D, Schemitsch E, Yee A, Kraemer W. Quality of life and

educational benefit among orthopaedic surgery residents: A prospective multi-centre

comparison of the night float and the standard call systems.

Canadian Spine Society 10th Annual Meeting. Lake Louise, Alberta, Canada, March

11 - 13, 2010.

Malempati H, Kreder H, Wadey V, Massicotte E, Yee A. Orthopaedic and neurosurgical

spine fellowship training: An evaluation of cognitive and technical competences.

Rampersaud R, Lewis S, Mohamed N, Davey R, Gandhi R, Wai E, Fisher C, Alexander D,

Oxner W, Bred A, Yee AJ, Finkelstein JA, Dvorak M. Post-operative improvement in

health related quality of life: A national comparison of surgical treatment for focal (1-2

level) lumbar spinal stenosis compared to total joint replacement for arthritis.

Rampersaud R, Lewis S, Wai E, Fisher C, Alexander D, Oxner W, Bred A, Yee AJ,

Finkelstein JA, Dvorak M. Health related quality of life following decompression

compared to decompression and fusion for degenerative spondylolisthesis: A Canadian

multicenter study.

Zahrai A, Palda V, Davis A, Yee A. The development of a preliminary preoperative

education tool for patients undergoing lumbar microdiscectomy utilizing multiple

stakeholder interview.

EORTC QLG Meeting. Rome, Italy, April 8 - 9, 2010.

Holden L, Chow E. Bone and brain metastases modules.

31

Holden L. Development of a quality of life (QOL) module for malignant spinal cord

compression (MSCC): Preliminary results for Phase I. Holden L. The EORTC Quality of Life Bone Metastases Modules update. Holden L. The EORTC Quality of Life Brain Metastases Module update. Holden L. The EORTC Quality of Life Modules for Bone Metastases and Brain Metastases.

MASCC/ISOO 2010 International Symposium. Vancouver, British Columbia,

Canada, June 24 – 26, 2010.

Caissie A, Holden L, Sahgal A, Culleton S, Zhang L, Chow E. Pre-treatment BN20+2 and

C15-PAL symptom and quality of life scores in patients with brain metastases.

Caissie A, Nguyen J, Holden L, Sahgal A, Zhang L, Chow E. Response to palliative

radiation of bone metastases associated with improved BM22 and C15-PAL symptom and

quality of life scores.

Culleton S, Mitera G, Zhang L, Presutti R, Swaminath A, Chow E. Patient expectations

and understanding of palliative radiotherapy treatment at a rapid response radiotherapy

clinic: A quantitative survey.

Culleton S, Salvo N, Zhang L, Leung M, Khan L, Presutti R, Nguyen J, Holden L, Zeng L,

Chow E. Predictive factors for anxiety and depression in advanced cancer patients.

Khan L, Culleton S, Zhang L, Salvo N, Chow E, Holden L. Comparing symptom severity

and demographics between two time periods in an outpatient palliative radiotherapy

clinic.

Khan L, Mitera G, Probyn L, Ford M, Zhang L, Chow E. Inter-rater reliability between

musculoskeletal radiologists and orthopaedic spinal surgeons on CT imaging features of

spinal metastases.

Nguyen J, Chow E, Zhang L, Culleton S, Holden L, Sahgal A. Palliative response and

functional interference outcomes using the brief pain inventory for spinal bony

metastases with conventional radiotherapy.

Nguyen J, Hayter C, Wong R, Danjoux C, Peltier J, Holden. A survey to assess patients

and patient awareness and interest in hypnosis for cancer pain and distressing

procedures.

University of Toronto Research Day. Toronto, Ontario, Canada, May 8, 2010.

Foote M, Massicotte EM, Sahgal A. Stereotactic body radiotherapy for spine metastases:

a novel approach following minimal access spine surgery.

Khan L, Holden L, Zhang L, Culleton S, Zeng L, Jon F, Wong K, Danjoux C, Tsao M,

Chow E. Prevalence of sleep disturbance in patients with bone metastases attending an

outpatient radiotherapy clinic.

Ruschin M, Nayebi N, Tamerou M, Li W, Sahgal A, Cho Y-B, Menard C, Jaffray D. Cone-

beam CT based evaluation of a novel head frame for intra-cranial stereotactic

radiotherapy. University of Toronto Annual Research Day, Toronto, Ontario, 2010.

32

Abstracts, Poster and Peer-reviewed Presentations

Akens M, Won E, Wise-Milestone L, Wilson B, Yee A, Whyne CM. Effect of photodynamic

therapy on breast cancer metastases in vertebrae of rats pre-treated with bisphosphonates.

(Poster) Orthopaedic Research Society Annual Meeting, New Orleans, Louisiana, March 5-9,

2010.

Akens M, Won E, Wise-Milestone L, Wilson BC, Yee AJM, Whyne CM. Outcome of

photodynamic therapy on breast cancer metastases in vertebrae of rats pre-treated with

bisphosphonates. Canadian Orthopaedic Association Annual Meeting, Edmonton, Alberta, June

18, 2010.

Cho Y, van Prooijen M, Tamerou M, Ruschin M, Zadeh G, Sahgal A, Laperriere N, Jaffray D,

Menard C. Implementation of hypofractionated and adaptive radiotherapy for large brain

metastases using a relocatable head frame on gamma knife perfexion. 15th International

Meeting of the Leksell Gamma Knife Society, Athens, Greece, May 16-20, 2010.

Cusimano MD, Schwartz M, Menard C, Hodaie M, Tsao M, Sahgal A, Zadeh G, Gentili F,

Michaels M, Bernstein M, Kondziolka D. Secondary trigemnial neuralgia and gamma knife: a

series and discussion. 15th International Meeting of the Leksell Gamma Knife Society, Athens,

Greece, May 16-20, 2010.

D‘Souza N, Loblaw DA, Mamedov A, Holden L, Sugar L. Prostate cancer pathology audits: Is

central pathology review still warranted? Genitourinary Cancers Symposium, San Francisco,

California, USA, March 5-7, 2010.

Dennis K. ―A pain in the back at the RRRP‖. Rapid Response Radiotherapy Program Quality

Assurance Rounds, Odette Cancer Centre, Toronto, Ontario, October 19, 2010.

Dennis K. ―Radiation-Induced nausea and vomiting: Variations on a theme‖. Odette Cancer

Centre, Sunnybrook Health Sciences Centre, Toronto, Ontario, October 21, 2010.

Dennis K. MR-Guided HIFU for the palliation of painful skeletal metastases: A pilot study.

Rapid Response Radiotherapy Program Educational Rounds. Odette Cancer Centre, Toronto,

Ontario, December 7, 2010.

Dennis K. Palliative radiotherapy: A Canadian perspective‖. Invited Speaker (Representative

for Canada). ASTRO Satellite Symposium: Coordinating the care of patients with advanced

cancer worldwide: Bridging the connection between palliative medicine specialists and

radiation oncologists. A worldwide perspective on palliative radiation oncology. The Institute

for Palliative Medicine at San Diego Hospice, San Diego, California, USA, October 30, 2010.

Emmenegger U, Berry SR, Booth C, Sridhar SS, Winquist E, Bandali N, Chow A, Kerbel RS, Ko

YJ. A phase II study of maintenance therapy with temsirolimus (TEM) after response to first-

line docetaxel (TAX) chemotherapy in castration-resistant prostate cancer (CRPC). ASCO

Genitourinary Cancers Symposium 2011, Orlando, Florida, USA, February 15-17, 2010.

Emmenegger U, Sridhar SS, Booth CM, Kerbel RS, Berry SR, Ko YJ. A phase II study of

maintenance therapy with temsirolimus (TEM) after response to first-line docetaxel (TAX)

chemotherapy in castration-resistant prostate cancer (CRPC). ASCO Annual Meeting 2010.

Journal of Clinical Oncology 28:15s, 2010 (suppl; abstr TPS246).

Emmenegger U. Antivascular Tumor Therapy. 2nd Molecular Oncology and Basic Sciences

Weekend, OncologyEducation.ca, Niagara-on-the-Lake, Ontario, July 10, 2010.

33

Emmenegger U. Antivascular tumor therapy. Basic Sciences Series IV: Angiogenesis, Hospital

for Sick Children, Toronto, Ontario, August 18, 2010.

Emmenegger U. Avascular necrosis of femoral head in patient with castration-resistant

prostate cancer. Rapid Radiation Response Program/Bone Metastasis Clinic (RRRP/BMC)

Research Rounds, Sunnybrook Odette Cancer Centre, Toronto, Ontario, October 19, 2010.

Emmenegger U. Castration-refractory prostate cancer. Medical Oncology Training Program

Orientation Week (University of Toronto), Toronto, Ontario, July 6, 2010.

Emmenegger U. Highlights from ASCO 2010: Prostate cancer update. Regional Medical

Oncologist CME (Amgen Inc.), Toronto, Ontario, June 22, 2010.

Emmenegger U. Systemic therapy update on castration-refractory prostate cancer. Regional

Urological Oncology CME (AstraZeneca Inc.), Toronto, Ontario, October 6, 2010.

Finkelstein J. 1) Orthopaedic Trauma, 2) Spine Trauma, 3) Metastatic Disease. Ecuador

Orthopaedic Society, Quito, Ecuador, April 19 - Apr 23, 2010.

Finkelstein J. Spine Surgery. Response Shift Think Thank, Boston, Massachusetts, USA,

September 19 - September 21, 2010.

Harsha Malempati (trainee presentation), Veronica Wadey, Hans Kreder, David Backstein, Eric

Massicotte, Albert Yee: Spine surgery fellowship training: A review of cognitive and technical

competencies. (Poster) 36th Annual Gallie Day, University of Toronto, Department of

Surgery, Toronto, Ontario, May 7, 2010.

Hojjat SP, Whyne CM: Automated Quantitative Analysis of Metastatic Disease in Rat Spine:

The Effects of Stereological Model and Spatial Resolution. Canadian Orthopaedic Association

Annual Meeting, Edmonton, Alberta, Jun 17, 2010.

Hojjat SP, Whyne CM. Automated quantitative analysis of metastatic disease in rat spine: The

effects of stereological model and spatial resolution. 18th Annual Symposium on

Computational Methods in Orthopaedic Biomechanics, New Orleans, Louisiana, USA, March 5,

2010.

Holden L. Interprofessional Collaboration in the RRRP/BMC. IPE (Interprofessional Education

course), Odette Cancer Centre, Toronto, Ontario, 2010.

Holden L. Lung mets, superior vena cava obstruction and liver mets. Department of Radiation

Oncology Master‘s Students,

Holden L. Percutaneous vertebroplasty. Department of Radiation Oncology Master‘s Students,

Odette Cancer Centre, Toronto, Ontario, 2010.

Holden L. The EORTC Quality of Life Bone, Brain and SCC Metastases module updates. RRRP

Meeting, Odette Cancer Centre, Toronto, Ontario, May 2010.

Holden L. Update on the development of the EORTC bone, brain and SCC modules. RRRP

Rounds, Odette Cancer Centre, Toronto, Ontario, 2010.

Hyde D, Lochray F, Sahgal A. Stereotactic body radiation therapy of the spine using he elekta

synergy, hexapod and BodyFIX systems. Radiotherapy and Oncology 96(2): S18, 2010.

34

Kreder M, Wright D, Whyne CM, Kreder H, Lubovsky O. Prognosticating acetabular fractures

using CT analysis. (Poster) Orthopaedic Research Society Annual Meeting, New Orleans,

Louisiana, March 5-9, 2010.

Larson D, Ma L, Barani I, Sahgal A, Descovitch M, Chuang C, Kunwar S, Petti P. Apparatus

dependent normal tissue dose for radiosurgery of multiple brain metastases. 15th

International Meeting of the Leksell Gamma Knife Society, Athens, Greece, May 16-20, 2010.

Leckie A, Akens M, Woodhouse K, Yee A, Whyne C. Mechanical evaluation of a novel nucleus

pulposus replacement material in health porcine discs. (Poster) 36th Annual Gallie Day,

University of Toronto, Department of Surgery, Toronto, Ontario, May 7, 2010.

Leckie A, Akens M, Woodhouse K, Yee A, Whyne C. Mechanical evaluation of a novel nucleus

pulposus replacement material in health porcine discs. (Poster) Canadian Connective Tissue

Conference, 16th Annual Meeting, Toronto, Ontario, June 4-5, 2010.

Li W, Sahgal A, Foote M, Millar B, Jaffray D, Letourneau D. Impact of immobilization on intra-

fraction motion for spine stereotactic body radiotherapy (SBRT) using cone-beam CT (CBCT).

International Journal of Radiation Oncology, Biology and Physics 78(3): S775, 2010.

Li W, Sahgal A, Foote M, Millar B-A, Jaffray D, Letourneau D. Impact of immobilization on

intra-fraction motion for spine stereotactic body radiotherapy (SBRT) using cone-beam CT

(CBCT). Radiotherapy and Oncology 96(2): S32, 2010.

Ma L, Hu W, Sahgal A, Larson DA. Effect and optimization of beam delivery sequence for

consistent biological effective dose realization in stereotactic radiosurgery treatments.

American Association of Physics in Medicine, Philadelphia, Pennsylvania. Medical Physics

37(6): SU-DD-A2-06, 2010.

Ma L, Sahgal A, Hwang A, Hu W, Chuang c, Descovich M, Larson DA. A two-step optimization

technique for planning multi-target treatments with robotic radiotherapy. American

Association of Physics in Medicine, Philadelphia, Pennsylvania. Medical Physics 37(6): SU-GG-

T-510, 2010.

Malempati H, Kreder H, Wadey V, Massicotte E, Yee A. Spine surgery fellowship training: An

evaluation of cognitive and technical competences. Canadian Orthopaedic Resident's

Association, Edmonton, Alberta, June 18, 2010.

Malempati H, Wadey V, Kreder H, Backstein D, Massicotte E, Yee A. Spine surgery fellowship

training: A review of cognitive and technical competencies. Scientific Day 2010, Institute of

Medical Sciences, Faculty of Medicine, University of Toronto, Toronto, Ontario, May 5, 2010.

Nayebi N, Ruschin M, Li W, Ménard C, Sahgal A, Jaffray D. Evaluation of inter-fraction setup

uncertainty of the cervical spine using a novel reloxatable head frame intended for intra-

cranial stereotactic radiotherpay. American Association of Physics in Medicine, Philadelphia,

Pennsylvania. Medical Physics 37(6): WE-C-BRA-01, 2010.

Pezeshki P, Akens M, Whyne C, Yee A. Application of cooled radiofrequency in a pre-clinical

metastasis model. 36th Annual Gallie Day, University of Toronto, Department of Surgery,

Toronto, Ontario, May 7, 2010.

Pezeshki P, Akens M, Whyne CM, Yee AJ. Application of cooled radiofrequency in a pre-clinical

metastasis model. (Poster) Canadian Connective Tissue Conference, 16th Annual Meeting,

Toronto, Ontario, June 4-5, 2010.

35

Ruschin M, Nayebi N, Li W, Cho Y, Sahgal A, Menard C, Jaffray D. Assessment of cervical

spine positioning and immobilization accuracy using a novel relocatable head frame intended

for intra-cranial stereotactic radiotherapy. International Journal of Radiation Oncology,

Biology and Physics 78(3): S138, 2010.

Sahgal A, Barani I, Novotny J, Zhang B, Petti P, Larson D, Ma L. Prescription dose guideline

based on physical criterion for multiple metastatic brain tumors treated with stereotactic

radiosurgery. 15th International Meeting of the Leksell Gamma Knife Society, Athens, Greece,

May 16-20, 2010.

Sahgal A, Ma L, Weinberg V, Gibbs I, Chao S, Chang U, Werner-wasik M, Fowler J, Wong S,

Larson D. Human spinal cord re-irradiation guidelines for stereotactic body radiotherapy.

International Journal of Radiation Oncology, Biology and Physics 78(3): S285, 2010.

Sahgal A, Ma L, Weinberg V, Gibbs I, Chao S, Chang U-K, Werner-wasik M, Angelov L, Chang

E. Re-irradiation spinal cord tolerance. Radiotherapy and Oncology 96(2): S34, 2010.

Sahgal A. Critical remarks on spine radiosurgery. 15th International Meeting of the Leksell

Gamma Knife Society, Athens, Greece, May 16-20, 2010.

Sahgal A. Poster discussant for the Radiation Oncology Research Day. University of Toronto,

Toronto, Ontario, 2010.

Sahgal A. Radiation for brain tumors. University of Toronto Neuroradiology Program

Professor‘s Rounds, Toronto, Ontario, 2010.

Sahgal A. Requirements for stereotactic body radiotherapy. McMaster University, Hamilton,

Ontario, 2010.

Sahgal A. Spinal cord tolerance for spine stereotactic body radiotherapy. Department of

Radiation Medicine Rounds, University of Toronto, Toronto, Ontario, 2010.

Sahgal A. Spine Radiosurgery. IMRT Insights: Transforming practice through collaboration.

Target Insights IV, Cancer care Ontario, Toronto, Ontario, 2010.

Sahgal A. Spine SBRT and minimal access spine surgery. PMH Innovation Rounds. University

of Toronto, Toronto, Ontario, 2010.

Sahgal A. Spine stereotactic body radiotherapy: A high dose approach for radioresistant

tumors. Melanoma Rounds, Odette Cancer Centre, University of Toronto, Toronto, Ontario,

2010.

Sahgal A. Stereotactic radiosurgery for brain metastases and neurocognition. 2010 William S.

Keiths lectureship day, University of Toronto, Division of Neurosurgery, University of Toronto,


Sahgal A. Stereotactic radiosurgery for recurrent spine tumors. University of California San

Francisco Update: Management of Recurrent Disease. San Francisco, California, USA, 2010.

Sahgal A. The management of brain metastases in 2010. Department of Radiation Medicine

Oncology Rounds, University of Toronto, Toronto, Ontario, 2010.

Sahgal A. The management of brain metastases in 2010. Oncology Grand Rounds, Odette

Cancer Centre, University of Toronto, Toronto, Ontario, 2010.

36

Sahgal A. The management of brain metastases in 2010. Sunnybrook Health Sciences Centre,

Division of Neurology Grand Rounds, University of Toronto, Toronto, Ontario, 2010.

Sahgal A. The management of brain metastases. Melanoma Rounds, Odette Cancer Centre,


Sahgal A. The management of brain metastases. Southlake Regional Cancer Centre Oncology

Rounds, Newmarket, Ontario, 2010.

Sahgal A. The management of malignant epidural spinal cord compression. Southlake

Regional Cancer Centre Oncology Rounds, Newmarket, Ontario, 2010.

Sahgal A. The treatment of paraspinal disease. Image-guided radiotherapy education course.

Princess Margaret Hospital, University of Toronto, Toronto, Ontario, 2010.

Sousa BA, Buckman RA, Clemons M, Dent SF, Wong NS, Kerbel RS, Sutherland DJ,

Emmenegger U, Gardner S, Pritchard KI. Phase I/II trial of metronomic chemotherapy with

daily dalteparin and cyclophosphamide, twice-weekly methothrexate, and daily prednisone

(DalCMP) as therapy for metastatic breast cancer (MBC). ASCO Annual Meeting 2010. Journal

of Clinical Oncology 28: 15s, 2010 (suppl; abstr 1152).

Weidong Du W, Yang BB, Yang BL, Deng Z, Shan S, Shatseva T, Fang L, Seth A, Yee A.

Versican G3 domain enhances breast cancer self renewal. (Poster) Canadian Connective

Tissue Conference, 16th Annual Meeting, Toronto, Ontario, June 4-5, 2010.

Weidong Du W, Yang BB, Yang BL, Deng Z, Shan S, Shatseva T, Fang L, Seth A, Yee A.

Versican G3 domain enhances breast cancer self renewal. (Poster) Canadian Orthopaedic

Association Annual Meeting, Edmonton, Alberta, June 17-20, 2010.

Wise-Milestone L, Akens M, Grynpas M, Yee A, Wilson B, Whyne C. Bone quality

characterization of a novel preclinical model of mixed osteolytic/osteoblastic vertebral

metastasis. (Poster) 36th Annual Gallie Day, University of Toronto, Department of Surgery,

Toronto, Ontario, May 7, 2010.

Wise-Milestone L, Whyne CM. Local treatment of mixed osteolytic/osteoblastic spinal

metastases: Is photodynamic therapy effective? (Poster) 10th International Conference on

Cancer-Induced Bone Disease, Sheffield, United Kingdom, September 22-25, 2010.

Wise-Milestone L, Won E, Akens M, Yee A, Wilson B, Whyne CM. The effect of photodynamic

therapy on structural integrity and skeletal remodelling of metastatically involved vertebrae,

alone and subsequent to bisphosphonate treatment. BONUS, Ottawa, Ontario, April 8, 2010.

Wise-Milestone L, Yeung C; Akens MK, Whyne CM. Understanding the effects of photodynamic

and radiation therapies on bone: Characterizing osteoblast response. (Poster) Canadian

Orthopaedic Research Society, Edmonton, Alberta, June 17-20, 2010.

Won E, Wise-Milestone L, Akens M, Burch S, Yee A, Wilson B, Whyne CM. Photodynamic

therapy: Tumor cell destruction and augmentation of structural integrity in the spine.

(Poster) Orthopaedic Research Society Annual Meeting, New Orleans, Louisiana, March 5-9,

2010.

Won E, Wise-Milestone L, Akens M, Burch S, Yee AJ, Wilson BC, Whyne CM. Beyond

bisphosphonates: Structural effects of photodynamic therapy on healthy and metastatically

involved vertebrae. (Poster) Orthopaedic Research Society Annual Meeting, New Orleans,

Louisiana, March 5-9, 2010.

37

Yee A. Do patient expectations relate to functional outcome following lumbar spinal surgery.

2010 Orthopaedic: Acute Care & Beyond Conference, Sunnybrook Health Sciences Centre,

Toronto, Ontario, April 9, 2010.

Yee A. Fundamentals of spine surgery: Anterior approaches to the thoracci and lumbar

spines and anterior instrumentation. U of T Spine Program; Inaugural Fellows Course (Chair:

Dr. S. Lewis); 'Fundamentals of Spine Surgery: An Introductory Course of Advanced Spinal

Techniques for Spine Fellows', Toronto, Ontario, August 6, 2010.

Yee A. Integration of Research with Clinical Practice -- Perspectives from Mid Career. Canada

and The United States Bone and Joint Decade: Young Investigators Initiative, Toronto,

Ontario, October 21-31, 2010

Yee A. Spinal injury in polytraumatized patients. From Hospital to Home - The Continuum of

Care after SCI (Joint Venture of: SHSC, UHN, Canadian Paragplegic Association Ontario),

Toronto, Ontario, January 21, 2010.

Yee A. The UT-SpineLINK Collaborative --Creation of a collaborative model to enhance the

triage and care of acute spine patients. Ministry of Health and Long Term Care -- Innovation

Fund Provincial Oversight Committee, Toronto, Ontario, November 18, 2010.

Yee A. Tumor-specific expression of versican / PG-M G3 domain promotes breast cancer cell

invasion and bone metastasis (William Du -- PhD Candidate Trainee Presentation). U of T,

Division of Orthopaedics Annual Research Day, Toronto, Ontario, October 20, 2010.

Yee AJ, Fehlings MG, Malempati H, Fawaz K, Singh A, Ginsberg H, Ahn H, Rice K, Webster F.

UT Spine Program: The UT-SpineLINK collaborative - creation of collaborative model to

enhance the triage and care of acute spine patients. (Poster) Ministry of Health and Long

Term Care -- Innovation Fund Provincial Oversight Committee, Innovation Fund Showcase,

Toronto, Ontario, Nov 18, 2010.



comparison of the night float and the standard call systems. Canadian Orthopaedic

Resident's Association, Edmonton, Alberta, June 18, 2010.



comparison of the night float and the standard call systems. (Poster) 36th Annual Gallie Day,

University of Toronto, Department of Surgery, Toronto, Ontario, May 7, 2010.

Zahrai A, Palda V, Davis A, Yee A. The development of a preliminary preoperative educational

tool for patients undergoing lumbar microdiscectomy using multiple stakeholder interviews.

(Poster) 36th Annual Gallie Day, University of Toronto, Department of Surgery, Toronto,

Ontario, May 7, 2010.

Zahrai A, Palda V, Davis A, Yee A. The development of a preliminary preoperative educational

tool for patients undergoing lumbar microdiscectomy using multiple stakeholder interviews.

(Poster) Canadian Orthopaedic Association Annual Meeting, Edmonton, Alberta, June 17-20,

2010.

38

APPENDIX A

Rapid Response Radiotherapy Palliative Clinics


Staff: Dr. E. Chow (Rad Onc), Dr. C. Danjoux (Rad Onc), Dr. M. Tsao (Rad Onc),

Dr. T. Barnes (Rad Onc), Dr. A. Sahgal (Rad Onc), L. Holden (RT), F. Jon (RT).

Objective:

Provide expedited access for symptom relief from incurable cancers in patients with limited life

expectancies.

Eligible Patients:

Symptomatic cancer (any disease site) where palliative radiotherapy may be indicated.

Patients with life expectancies of <6 months.

A ―most responsible physician‖ available to provide follow-up and ongoing oncological care

upon completion of the RRRP consultations.

Ineligible Patients:

1. Candidates for potentially curative treatments.

2. Patients requiring further investigations before radiotherapy opinion can be rendered.

3. Patients who are currently actively being followed by a radiation oncologist at

OCC (unless otherwise specifically arranged).

4. Patients whose disease status is better served by a radiation oncologist who could provide

longitudinal follow-up.

5. Off-service in-patients who require transfer of care to radiation oncology for ongoing oncological

care.

Monday Dr. T. Barnes Sim 4

Tuesday Dr. M. Tsao Sim 4

Wednesday Dr. C. Danjoux Sim 4

Thursday Dr. E. Chow Sim 4

Friday Dr. M. Tsao Sim 4

To make a referral:

1. Fill out an e sheet when requesting a referral to the RRRP clinic.

2. Contact the RRRP nurse.

3. Contact one of the RRRP physicians directly.


39

APPENDIX B

Decision Tree for Patients Referred to RRRP / BMC (January 2001)

Yes No

No

Yes No

Yes

Refer to his / her Rad Onc

To site group based on diagnosis

- lung

- breast - GU etc.

Emergency Urgent Elective < 24 h <1 week Book next available RRRP slot

(Cord Compression (Bleeding, Do not book beyond 2 weeks SVCO) SOB)

No Yes

YES YES

No

** RRRP Policy circulated as addendum to Minutes of Radiation Oncology staff meeting of March 2

nd 2000.

Is patient new to TSRCC?

Did patient see a TSRCC Rad Onc?

Is patient estimated

survival greater than 6 months?

What is the urgency of

appointment?

Is RRRP slot available?

Discuss with RRRP Rad Onc who has a clinic for that day or next few days. Is RRRP Rad Onc able to see patient?

overbook patient to Rad Onc in RRRP inform ref MD and patient

Refer to Rad Onc on call

40

APPENDIX C

Jan 1999: Initiated Bone Metastases Clinic (BMC)

A bi-weekly Bone Metastases Clinic (BMC) was initiated at the OCC on January 8, 1999. The clinic

is staffed by Orthopaedic Surgical Oncologists: Drs. T. Axelrod, J. Finkelstein, D. Stephen,

M. Ford and A. Yee; Radiation Oncologists: Drs. E. Chow, C. Danjoux, M. Tsao, T. Barnes;

Radiation Therapists.

The BMC is held on the 2nd and 4th Friday morning of each month in clinic C at the OCC.

The goals of the BMC are to:

Provide an elective orthopaedic consultation service for patients with bone metastases

referred by OCC oncologists; provide elective radiation oncology consultations to patients

with bone metastases referred by SWHSC physicians.

Provide elective orthopaedic and radiation oncology consultations to patients with bone

metastases referred by community physicians.

Provide follow-up to oncology patients after orthopaedic interventions.

Bone Metastases Clinic – 2nd and 4th Friday (Clinic C)

To make a referral:

1. Fill out an e sheet when requesting a referral to the Bone Metastases Clinic.

2. Contact the RRRP nurse or Radiation Therapist.

3. Contact one of the RRRP physicians directly.

41

APPENDIX D

42

APPENDIX D

59

APPENDIX E [Back]

Content of HOT SPOT Newsletter

1999-2010

60

CONTENT AND INSERTS OF HOT SPOT 1999-2010

Vol 1, Issue 1 February 1999

Editor‘s Corner Dr. Gillian Thomas

From the Chief Executive Officer Dr. Ken Shumak

The first RRRP newsletter Dr. Gillian Thomas

Palliative radiotherapy rounds Dr. Ewa Szumacher

New combined bone metastases clinic Drs. Joel Finkelstein, Edward Chow

A phase II trial of palliative radiotherapy for metastatic renal cell carcinoma

Drs. Edward Chow, Padraig Warde

Prospective assessment of symptom palliation for patients attending a rapid response radiotherapy program

Drs. Edward Chow, Cyril Danjoux, Rebecca Wong

The challenge of speedy delivery of pain relief met by the rapid response clinic at T-SRCC

Dr. Ewa Szumacher, Ms. Lou Andersson

The cancer pain and palliative care clinic at T-SRCC Dr. Larry Librach

Research Corner Dr. Rebecca Wong

Vol 1, Issue 2 May 1999

Message from the Chief Executive Officer Dr. Carol Sawka

A note of thanks

Ms. Ruth Connolly,

Dr. Edward Chow

Editor‘s Corner

Differentiating normal grief from clinical depression Dr. Mary Vachon

Ontario Drug Benefit (ODB) Formulary Changes Ms. Trudi Schueller

Surgical management of metastatic spine disease Dr. Joel Finkelstein

Radiosurgery for brain metastases Dr. Phillip Davey

Surgical management of metastatic extremity lesions Dr. David Stephen

Highlights in the Multinational Association of Supportive Care Cancer Dr. Rebecca Wong

Insert May 1999

Cancer Related Pain Management (Sponsored by Janssen-Ortho Inc.) Dr. David Warr

Vol 1, Issue 3 August 1999 Referring physicians‘ satisfaction with the RRRP

Ms. Ruth Connolly, Dr. Edward Chow

Preparing the community and health care professionals for new challenges

in palliative care – a new endeavour of the rapid response radiotherapy program

Ms. Lou Andersson, Dr. Ewa Szumacher

Editor‘s Corner

Management of bone metastases with external beam radiotherapy Drs. Ewa Szumacher and Rebecca Wong

Single dose wide field radiotherapy Dr. Cyril Danjoux

Bisphosphonates in palliative care Dr. Sandeep Sehdev

Mitoxantrone and prednisone for hormone refractory prostate cancer Dr. Scott Berry


Insert August 1999

Malignant wound management (Sponsored by Convatec) Dr. Valerie Schultz

Vol 1, Issue 4 November 1999

Bayview Support Network: Ontario‘s first on-site cancer support network Ms. Mridula Sood

Dope and cope: it is no longer enough Dr. Michele Chaban

Editor‘s comment

Psychosocial issues with a cancer diagnosis Dr. Margaret Fitch

Cancer care at York Central Hospital Ms. Jane Anderson

Yee Hong palliative care services: A culturally sensitive approach Dr. Stanley Zheng

Hill House – A Richmond Hill hospice Ms. Ann Gold

61

Charles R.R. Hayter, MD, BA, MA, FRCPC joins T-SRCC

Interview with Russell Goldman, MD, CCFP, palliative care physician with

the Temmy Latner Centre for Palliative Care, Mount Sinai Hospital


Insert November 1999

Bowel Obstruction Dr. Larry Librach

Management of Radiotherapy-Induced Acute Gastrointestinal Toxicities Dr. Rebecca Wong

(Sponsored by Novartis Pharmaceuticals Canada, Inc.)


Editor‘s comments Dr. Cyril Danjoux

Advance care planning for people with cancer Dr. Scott Berry

The emotional needs of the person with advanced cancer Dr. Mary Vachon

Historical Vignette: The beginnings of palliative radiotherapy in Canada Dr. Charles Hayter

When does palliative care begin? Dr. Larry Librach

Palliative radiation oncology program at the Princess Margaret Hospital Dr. Andrea Bezjak

Ask the Experts Dr. Rebecca Wong


Insert February 2000

Prevention and treatment of radiation-induced emesis Dr. Rebecca Wong

Prevention and treatment of chemotherapy-induced nausea and vomiting (N&V) - (Sponsored by Glaxo-Wellcome) Mr. Carlo De Angelis


From the associate editor‘s desk Dr. Edward Chow

Enhancing culturally sensitive practice when caring for seriously ill patients and their families Dr. Elizabeth Latimer

Quality end-of-life care: What do patients think? Dr. Scott Berry

Family dealing with advanced cancer Dr. Mary Vachon

Percutaneous vertebroplasty / cementoplasty at bone metastases clinic, TSRCC Dr. Edward Chow

Historical Vignette: Dr. Joseph-Ernest Gendreau and the early use of radium Dr. Charles Hayter


Insert May 2000 Accessing palliative care in your community

Ms. Joan Pope,

Ms. Lou Andersson

Vol 2, Issue 3 August 2000 From the editorial board

Dr. Ewa Szumacher, Ms. Ruth Connolly

When the patient of a young child is seriously ill Dr. Mary Vachon

Disclosure Dr. Philip Hebert

Utilization of complementary therapies in palliative care Ms. Ruth Connolly

Historical Vignette: Private radiotherapy in Canada Dr. Charles Hayter

Research Corner - Summer research for the Rapid Response Radiotherapy Program Dr. Rebecca Wong

Andrew Loblaw, MD, FRCPC, joins T-SRCC

Insert August 2000

-Nutrition and cancer

-The ABCs of vitamins and minerals (Supported by Novartis Pharmaceuticals Canada, Inc.) Ms. Elaine Posluns


Editor‘s Corner Dr. Rebecca Wong

Report from the ―tri-centre‖ meeting with Dr. William E. Powers Dr. Jackson Wu

Adolescents living with a parent with advanced illness Dr. Mary Vachon

Resources on the Internet for improving end-of-life care – How to get started Dr. Scott Berry

Historical Vignette: Vera Peters: Canadian pioneer in psychosocial oncology Dr. Charles Hayter

Research Corner – Informational needs assessment on patients receiving palliative radiotherapy Dr. Rebecca Wong

62

Seventh Annual Conference – The Science and Art of Pain and Symptom Management


Cancer-related fatigue -Supported by an educational grant from Janssen-Ortho Inc. Dr. Rebecca Wong

Vol 3, Issue 1

February 2001 From the associate editor‘s desk Dr. Edward Chow

Dr. Maureen Trudeau Dr. Kathleen Pritchard

Staff stress and suffering Dr. Mary Vachon

Historical Vignette: Cancer care before medicare Dr. Charles Hayter

Pain and symptom management conference

Follow-up for breast cancer Dr. Eva Grunfeld

Research Corner – Shared treatment decision-making Dr. Rebecca Wong

Thank you…


-Hormones in Breast Cancer, Metastatic Breast Cancer (Supported by Astra-Zeneca Canada Inc.)

Dr. Maureen Trudeau

-Chemotherapy in Metastatic Breast Cancer Treatment, Treatment of

Systemic Recurrence with Chemotherapy (Supported by Aventis)

Dr. Maureen Trudeau

-Herceptin (Supported by Hoffman LaRoche) Dr. Maureen Trudeau


From the guest editor's desk Dr. Charles Hayter

Addressing spiritual needs Dr. Sharon Grant

When the shrink gets cancer and gets spiritually transformed Dr. Mary Vachon

Historical Vignette: The history of hospices Dr. Charles Hayter

Ethics: Caring for patients with different faiths Dr. Scott Berry

Research Corner - Patient expectations Dr. Rebecca Wong

Notice regarding treatment delays...

Insert May 2001

A guide to spiritual care of the caregiver, A guide to spiritual assessment of cancer patients. (Supported by AstraZeneca Canada Inc. and Purdue Pharma)

Dr. Michele Chaban

Vol 3, Issue 3 August 2001

From the editor's desk Dr. Cyril Danjoux

Comfort and stress among cancer caregivers Dr. Eva Grunfeld

On suffering in terminal illness Dr. Mary Vachon

Historical Vignette: The history of morphine Dr. Charles Hayter


Insert August 2001 Palliation in lung cancer

(Supported by AstraZeneca Inc. and Purdue Pharma)

Drs. Andrea Bezjak, Dr. Catherine Heath, Ms. Jane Lea


From the guest editor's desk Dr. Andrew Loblaw, Ms. Lori Holden

Survey shows 40% of RRRP patients arrive with missing info: A plea for help

Dr. Charles Hayter, Ms. Ruth Connolly

Finding meaning in life in the face of advancing cancer Dr. Mary Vachon

Historical Vignette: The 50th anniversary of cobalt treatment Dr. Charles Hayter

Tough decisions about funding for new palliative therapies: How do we decide? Dr. Scott Berry



Malignant Spinal Cord Compression (Partially supported by Purdue Pharma)

Dr. Andrew Loblaw, Ms. Lori Holden

Vol 4, Issue 1 February 2002 From the editor's desk

Dr. Ewa Szumacher, Ms. Joan Pope

63

Advance notice of the ninth annual conference on the science and art of pain and symptom management

Denial and minimization in advanced cancer Dr. Mary Vachon

Global health ethics and palliative care Dr. Scott Berry

Historical Vignette: The story of Essiac Dr. Charles Hayter



Oral health care in the patient with cancer Dr. Trey Petty

Mouth care for radiation patients Dr. Alex Hammond

(Supported by Biotene Canada, Division of Bolton Dental Mfg. Inc.)

Vol 4, Issue 2

May 2002 From the associate editor‘s desk Dr. Edward Chow

New chiefs at TSRCC and University of Toronto Dr. Edward Chow, Dr. Cyril Danjoux

Depression in advanced cancer Dr. Mary Vachon

Historical Vignette: Blood and medicine Dr. Charles Hayter

Hope for a good death Dr. Monica Branigan


Insert May 2002

Anemia in hematology and medical/radiation oncology (Supported by Ortho Biotech)

Dr. Gerard Morton, Dr. Rena Buckstein

Vol 4, Issue 3 August 2002 From the associate editor‘s desk

Ms. Lou Andersson, Dr. Cyril Danjoux

TSRCC pharmacy services Ms. Kim Stefaniuk

The transformation from tragedy into grace in terminal illness – part one Dr. Mary Vachon

Historical Vignette: Plants, poisons and potions: Drug treatments for cancer Dr. Charles Hayter

TSRCC pharmacy assists Third World countries Ms. Kim Stefaniuk

Informed decision-making in palliative care Dr. Scott Berry

Research Corner Dr. May Tsao, Dr. Rebecca Wong

Insert August 2002

Accessing medication

(Supported by Amgen Canada and Abbott Laboratories) Ms. Kim Stefaniuk


From the associate editor‘s desk Dr. Edward Chow

Palliative care is not euthanasia Dr. Monica Branigan

The transformation from tragedy into grace in terminal illness – part two Dr. Mary Vachon

Palliative care at the University of Texas M.D. Anderson Cancer Center Dr. Toni Barnes

Historical Vignette: Charles Huggins: The Canadian who discovered hormone therapy for prostate cancer Dr. Charles Hayter


Award of Excellence Dr. Cyril Danjoux


Expanded role of hormone therapy as neoadjuvant or adjuvant therapy in

prostate cancer patients undergoing definitive treatment. (Supported by Aventis)

Dr. Richard Choo

Vol 5, Issue 1 February 2003 From the editor‘s desk

Drs. Cyril Danjoux,

Edward Chow

Congratulations on fifth year Dr. Carol Sawka

Congratulations on fifth year Dr. Peeter Poldre

Suffering, healing and the wounded healer Dr. Mary Vachon

More fifth year congratulations Dr. Shun Wong

Advance care planning – update and practical tips Dr. Scott Berry

Historical Vignette – A century of radiation therapy in Canada Dr. Charles Hayter


64


Pain in cancer: The CARE approach Dr. Larry Librach

Vol 5, Issue 2 May 2003 From the guest editor‘s desk

Dr. Charles Hayter,

Ms. Lou Andersson

The role of the social worker in palliative oncology Ms. Magdalene Winterhoff

Reflections on anxiety in confronting advanced cancer Dr. Mary Vachon

Historical Vignette – Spring fever Dr. Charles Hayter


Insert May 2003

Advances and challenges in the management of febrile neutropenia. (Supported by Amgen Canada Inc.)

Dr. Elizabeth J. Phillips


From the guest editor‘s desk Dr. Toni Barnes

Lymphoma in the elderly Dr. Tom Kouroukis

Demorarlization in persons with advanced cancer Dr. Mary Vachon

Ethical issues in dealing with demands for ―futile‖ treatment Dr. Scott Berry

Historical Vignette – The history of oxygen therapy Dr. Charles Hayter


Insert August 2003 Advances for end-of-life respiratory care (Supported by Vital Aire) Dr. Chin K. Chung


From the guest editor‘s desk Dr. Cyril Danjoux

Referral of patients to the rapid response radiotherapy clinic

Boredom in terminal illness Dr. Mary Vachon

Hot Spot Survey 2003

―No CPR‖ – Talking it over Dr. Scott Berry

Historical Vignette – The Radium Institute of Toronto Dr. Charles Hayter

Research Corner Dr. Andrea Bezjak

Insert November 2003 Androgen ablation for metastatic prostate cancer (Supported by Aventis)

Dr. Richard Choo


From the guest editor‘s desk Dr. May Tsao

Brain metastases: The magnitude of the problem and the struggle to improve outcomes Dr. May Tsao

Dignity-conserving care in palliative care Dr. Mary Vachon

When capacity fluctuates, what happens to consent? Ms. Karen Faith

Historical Vignette: The Montreal Neurological Institute Dr. Charles Hayter

Research Corner Dr. Alina Sturdza, Dr. Andrea Bezjak


Palliation in patients with metastatic cancer to the brain

Management of brain metastases (Supported by Aventis)

Dr. May Tsao


From the guest editor‘s desk Dr. Charles Hayter

Bisphosphonates in cancer Dr. Rebecca Wong

Anger in the person with advanced disease Dr. Mary Vachon

Ethics and SARS: Collateral damage and relationships in health care Ms. Karen Faith

Historical Vignette: Dr. Herbert Bruce: Ontario cancer visionary Dr. Charles Hayter

Research Corner Dr. Jackson Wu, Dr. Edward Chow

Insert May 2004

Use of bisphosphonates in men with hormone refractory prostate cancer Use of bisphosphonates in women with breast cancer

Dr. Scott Berry Dr. Mark Clemons

Vol 6, Issue 3 From the guest editor‘s desk Dr. Cyril Danjoux

65

August 2004 Supportive Care in Cancer Symposium Dr. Cyril Danjoux

Forgiveness in palliative care Dr. Mary Vachon

Making decisions for others Ms. Karen Faith

Survey shows 40% of RRRP patients arrive with missing info: A plea for help

Dr. Charles Hayter, Ruth Connolly

Research Corner Dr. Laura Dawson

Insert August 2004

Rapid Response Radiotherapy Program (RRRP) Review 1996-2003 RRRP Referral Form

Dr. C. Danjoux


From the guest editor‘s desk Dr. Edward Chow

The effect of SARS on access to palliative radiotherapy in the RRRP

Dr. Justin Lee, L. Holden, K. Fung,

C. Danjoux, E. Chow, C. Gillies

Reflections on the life and death of Mary Peacock Dr. Mary Vachon

Quality end-of-life care: Role of economics and the moral climate Ms. Karen Faith

Historical Vignette: The Canadian Society for the History of Medicine Dr. Charles Hayter

Research Corner

Dr. Jackson Wu,

Dr. Edward Chow


Cannabinoids in medical practice Dr. Vincent Maida



Treatment of bone metastases with palliative radiotherapy: Patients‘ treatment preferences

Dr. Ewa Szumacher

Parenting teens during a cancer experience Dr. Mary Vachon

Hospital CPR policy: Solution, prevention or band-aid? Ms. Karen Faith

Historical Vignette: Alfred Hardisty: Ontario‘s pioneer in cancer statistics Dr. Charles Hayter



Methadone for cancer pain: An analgesic with a difference Dr. Larry Librach

Vol 7, Issue2 May 2005


The do-not-resuscitate (DNR) order – incidence of documentation in patient charts of patients referred for palliative radiotherapy

Ms. Lou Andersson, Ms. Nicole Bradley

Caught in the middle – mid-life adults with cancer Dr. Mary Vachon

Does culture influence patients‘ and families‘ DNR decision-making?

Ms. L. Andersson,

S. Mary Williams, N. Bradley

Lessons from my dad Ms. Karen Faith

Temmy Latner Centre Update on Palliative Care – Palliative care and children

Mr. Stephen Jenkinson

PROG Rounds Dr. Tanya Berrang

Farewell to Dr. Charles Hayter Dr. Cyril Danjoux

Insert #1 May 2005

Latest advances in antiemetics for radiation therapy and chemotherapy

(Supported by an educational grant from Solvay) Dr. David Warr

Insert #2 May 2005

Novel therapeutics for management for multiple myeloma (Supported by an educational grant from Ortho Biotech)

Dr. Keith Stewart



A survey to asses cancer patients‘ awareness and interest in hypnosis for pain and distressing procedures – A synopsis

Mrs. Lori Holden, Dr. Charles Hayter

Are we making any progress? Reflections on stressors in the Ontario oncology system over the past 30 years Dr. Mary Vachon

Organizational ethics in the eye of the storm: Woodside Hospice and Terri Ms. Karen Faith

66

Schiavo

Temmy Latner Centre Update on Palliative Care – End-of-life care distance

education: An innovative approach to helping physicians to care for palliative patients

Dr. Anita Singh, Ms. Deborah Adams

TSRCC investigates advanced practice radiation therapy roles! Ms. S. Robson, R. Barker, L. Holden

Insert August 2005

A more minimally invasive approach to the treatment of metastatic spine lesions. (Supported by an educational grant from Kyphon)

Dr. Michael Ford



What keeps us going in our work? Dr. Mary Vachon

Research ethics and the importance of determining risk Ms. Karen Faith

Temmy Latner Centre Update on Palliative Care – Is terminal sedation ethical?

Dr. Victor Cellarius

Research Corner – Results of three important randomized studies and their clinical implications. Dr. Jackson Wu


Management of hormone refractory prostate cancer / Prostate bone

metastases multidisciplinary clinic. (Supported by an educational grant from Novartis)

Dr. Yoo-Joung Ko



Greetings from Cancer Care Ontario Dr. Linda Rabeneck, Dr. Deb Dudgeon

Hope in advanced disease Dr. Mary Vachon

Temmy Latner Centre Update on Palliative Care – Palliative care grand rounds Ms. Deborah Adams

Private clinics providing palliative IV therapies – What are the ethical

issues? Dr. Scott Berry

Helping children and caregivers in fighting cancer – Truth telling in paediatric palliative care. Dr. Christine Newman

Research Corner Dr. Toni Barnes


Venous thromboembolism in cancer patients (Supported by an educational grant from Pfizer Canada) Dr. Agnes Y.Y. Lee



Truth-telling at the end of life Dr. Monica Branigan

What students think: Undergraduate students in palliative health care setting Ms. Hannah H. Chiu

Temmy Latner Centre Update on Palliative Care – The educating future physicians for palliative and end-of-life care project (EFPPEC): Developing competencies in medical undergraduates and postgraduates Dr. Larry Librach

Help no wanted? Dr. Margaret Fitch

If symptom clusters exist, how are they relevant to patient care? Dr. Amna Husain

Forgoing nutrition and hydration in children at the end of life: Is it ever justified? Dr. Adam Rapoport

Insert May 2006

Radioimmunotherapies

(Supported by an educational grant from GlaxoSmithKline) Dr. Rena Buckstein


From the guest editor‘s desk Ms. Emily Sinclair

Hope, denial and ethics of care Ms. Karen Faith

The role of a child life specialist at the MBWC-CGPC Ms. Ceilidh Eaton Russell

Quality indicators of end-of-life care in Ontario cancer patients Dr. Lisa Barbera

Palliative care consult team: Moving forward Dr. Jeff Myers

16th Annual provincial conference on palliative and end-of-life care Ms. Emily Sinclair

67

Patients‘ and health care professionals‘ perspectives on the most important quality of life issues in bone metastases

Ms. S.Tharmalingam and Ms. Kristin Harris

Interprofessionalism: A culture of caring Dr. Michele Chaban

Insert August 2006

Video/teleconference as a tool to facilitate research and development in palliative radiotherapy – the Canadian model

Kathryn Burrows, Rebecca Wong,

Andrea Bezjak, Jackson Wu, Graeme Duncan, Rajiv Samant, Jim Wright, Frances Wong, and Cyril Danjoux



Ethics and preparing for pandemic influenza Ms. Karen Faith

Research Column – Symptom control abstracts presented at the annual Canadian Association of Radiation Oncologist (CARO) meeting

Dr. Toni Barnes

Demanding to live Mr. Stephen Jenkinson

Temmy Latner Centre Update on Palliative Care –Tariro (hope) Dr. Sandy Buchman

Communicating with children about dying Ms. Jennifer B. Pond, Ms. Ceilidh E. Russell

Exploring occupational therapy‘s role – Working with palliative clients and their families

Ms. Amy Tymchuk


New developments in the treatment of advanced renal cell carcinoma (RCC) (Supported by an educational grant from Pfizer) Dr. Yoo-Joung Ko


From the guest editor‘s desk Dr. Lisa Barbera

The alchemy of healing: Are we wired for compassion? Dr. Mary Vachon

Provincial Palliative Care Integration Project (PPCIP): Enhancing the quality of palliative care services

Dr. Deborah Dudgeon and Raquel Shaw

Moxam

Issues in the measurement and management of dyspnea in home

palliative care patients: Who might benefit from oxygen therapy and how should they qualify?

Ms. Erica Moran and

Dr. Amna Husain

Redirecting hope Dr. Christopher

Church

Capacity and consent: Separating fact from fiction Mr. Blair Henry

Temmy Latner Centre Update on Palliative Care – Computerization in palliative care

Dr. Albert Kirshen

Insert Nov 2006

Advances in iron chelation for myelodysplastic syndromes (Supported by an educational grant from Novartis)

Dr. Rena Buckstein


From the associate editor‘s desk Dr. Cyril Danjoux

…on the truth of the matter!?! Mr. Blair Henry

Living after cancer: Challenges in being a survivor Dr. Margaret Fitch

Improving communication during the palliative care of children with brain

tumours – learning from experience

Ms. Ceilidh Eaton

Russell

Symptom clusters in cancer patients with bone metastases Ms. Stephanie Hadi, Grace Fan, Linda

Filipczak

New imaging studies in locally advance breast cancer Drs. Gregory Czarnota, Rebecca Dent, Jacqueline Spayne, Maureen Trudeau, Kathleen

Pitchard, Martin Yaffe,

68

Don Plewes, and Peter Burns

The Rapid Access Palliative Radiotherapy Program: New kid in town Dr. Alysa Fairchild

Insert May 2007

Emerging role of chemotherapy in early prostate cancer (Supported by an educational grant from Sanofi-Aventis)

Dr. Rena Buckstein


From the editor‘s desk Dr. Edward Chow

Error in health care Dr. Philip Hebert

Edmond and Gloria Odette make landmark investment at Sunnybrook to help fight cancer

Ms. Natalie Chung-Sayers

Suffering, taboos and interventions Dr. Michele Chaban

New initiatives in advance care planning in Canada Dr. Larry Librach

Review of the Rapid Response Radiotherapy Program (RRRP) at the Odette Cancer Centre (OCC)

Dr. Toni Barnes

Insert August 2007

New options for the treatment of moderate pain (Supported by an educational grant from Purdue Pharma)

Dr. Sol Stern



What hope can mask: Talking to children about life-threatening illness and death

Ms. Lysa Toye

The role of experience and meaning in clinical ethics Ms. Karen Faith

The role of the therapeutic clown in the care of children with progressive

life-limiting conditions

Ms. Camilla Gryski

Provincial integration project moving forward at Odette Cancer Centre Ms. Martha Wyatt

Update: New options for the treatment of moderate pain Dr. Sol Stern

New research in palliative care Ms. Shannon Ellis, Ms. Linda Wood, Dr. Lorraine Wood

Health care professionals‘ perception of what defines ―meaningful palliative care‖ in a palliative care unit

Ms. Julie Napolskikh, Drs. Jeff Myers, Debbie Selby

Insert #1 November 2007

Update in the management of colorectal cancer (Supported by an educational grant from Sanofi-Aventis)

Dr. Yoo-Joung Ko


The evolving role of cannabinoids in supportive oncology (Supported by and educational grant from Bayer Inc.

Dr. Vincent Maida



Talking to dying patients Dr. Scott Berry

Being ready for pediatric palliative care – a person reflection Dr. Christine Newman

Involvement of family physicians in the care of patients seen in the Rapid Response Radiotherapy Program

Dr. Toni Barnes

Resilience in palliative care Dr. Mary Vachon

The WHO analgesic ladder and new concepts in our understanding of cancer pain – building on the legacy

Dr. Carlo DeAngelis

Development of the Bone Metastases Module to accompany the EORTC

core questionnaire to assess quality of life in patients with bone metastases in future clinical trials

Ms. Amanda Hird


Management of invasive fungal infections (IFIs) in immunocompromised patients (Supported by an educational grant from Astellas Pharma Canada, Inc.)

Dr. Jeffrey H. Lipton



Resilience in professional caregivers Dr. Mary Vachon

Are some GIM patients missing a palliative medicine consult when they Drs. Leah Steinberg,

69

might benefit from it? Anita Chakraborty, Niren Shetty

Advanced directives or advanced troubles? Mr. Blair Henry

Advance care planning in pediatric palliative care: Dr we really know what they are asking?

Ms. Maria Rugg

Improving cancer pain control: Helping patients to gain the most benefit

from their medication

Dr. Carlo DeAngelis

Insert May 2008

Sorafenib in the treatment of advanced heptocellular cancer (Supported by an educational grant from Bayer)

Ms. Anne Horgan, Dr. Jennifer Knox



Only talk about positive things! Dr. Monica Branigan

Decision-making in a family dyad in the context of advanced cancer Ms. Susanna Edwards

Screening for emotional distress: The sixth vital sign Dr. Margaret Fitch

Opioid Dose Equivalency: Part 1 – General Overview Dr. Carlo DeAngelis

Insert #1 August 2008

Secondary prophylaxis of venous thromboembolism (VTE) in cancer patients (Supported by an educational grant from Pfizer)

Dr. Richard Jay


Prostate bone metastases clinic (PBMC): A multidisciplinary approach (Supported by an educational grant from Novartis)

Dr. Urban Emmenegger



Spine stereotactic body radiotherapy Dr. Arjun Sahgal

Stereotactic body radiation therapy for lung tumours Dr. Patrick Cheung

Disclosure and palliative chemotherapy Dr. Philip Hebert

Determining outcomes for patients with metastatic epidural spinal cord

compression (MESCC): A quality of life and cost-effectiveness study

Dr. Arjun Sahgal, Ms.

Aimee Gallant, Drs. Michael Fehlings, Edward Chow, Joel Finkelstein

Bringing about change Dr. Michele Chaban


Smoking cessation and reduction in patients with cancers (Supported by

an educational grant from Pfizer)

Dr. Peter Selby

Vol 11, Issue 1

February 2009 From the guest editor‘s desk Dr. Toni Barnes

Maintaining Ontario‘s blood supply: A fine balancing act Ms. Debbie Lauzon

De Moto Sanquinas (on the movement of blood) Ethics across the spectrum of transfusion

Mr. Blair Henry

Psychosocial aspects of the use of blood products Dr. Mary Vachon Insert February 2009

Myelodysplastic syndromes (Supported by an education grant from Celgene)

Dr. Rena Buckstein



―Be patient‖: Ethical considerations regarding wait times Ms. Karen Faith

Dying-centred care for the dying Mr. Stephen Jenkinson

Opioid dose equivalency: Part 2 – Changes in opioid route or mode of administration

Dr. Carlo DeAngelis

Integrating continuous quality improvement in a home palliative care program

Ms. Ceilidh Eaton Russell, Mr. Christopher Obwanga, Ms. Natalie Parry, Dr. Amna Husain

Nursing escort for patients attending Rapid Response Radiotherapy

Program (RRRP)

Ms. Lynn Faltl and

Pager Office Nursing Staff

70

Insert

May 2009 Individualizing a cancer pain management strategy: Beyond the basics

(Supported by an education grant from Sanofi-Aventis)

Drs. Carlo DeAngelis,

Jeff Myers Vol 11, Issue 3 August 2009


Limits of the duty of care: Lessons from the Golubchuk case Dr. Monica Branigan

A multicentre assessment of the adequacy of cancer pain treatment using the Pain Management Index

Ms. Gunita Mitera, Drs. Alysa Fairchild, Rebecca Wong

Opioid dose equivalency: Part 3 – Opioid switching with morphine-like opioids

Dr. Carlo DeAngelis

2009 Annual Hospice Palliative Care Conference Ms. Gunita Mitera Insert #1 August 2009

Chronic lymphocytic leukemia (CLL) (Supported by an education grant from Roche)

Dr. Rena Buckstein


Treatment of chemotherapy- and radiotherapy-induced nausea and vomiting (CINV/RINV) (Supported by an education grant from Merck Frosst Canada Ltd.)

Drs. Mark Pasetka, Carlo DeAngelis


From the guest editor‘s desk Dr. Arjun Sahgal

A brief primer on scarcity and fairness Dr. Philip Hébert

Are family caregivers an essential component of our health care system? Dr. Michele Chaban

Ethics Centre launches new on-line consult request on Sunnynet! Dr. Sally Bean

Improving data capture and standardization in a home palliative care program

Mr. Christopher Obwanga

Opioid dose equivalency: Part 4 – Dose conversion for transdermal fentanyl and methadone

Dr. Carlo DeAngelis


Anti-epidermal growth factors in colorectal cancer (Supported by an education grant from Amgen)

Dr. Yoo-Joung Ko


Management of symptomatic side effects of anti-hormonal therapy in breast cancer survivors (Supported by an education grant from Pfizer)

Dr. Christine Simmons



Projected referral for health care services in an outpatient palliative radiotherapy clinic

Ms. Roseanna Presutti, Dr. Elizabeth Barnes

Caring and moral distress: Why do I feel so bad? Ms. Karen Faith

An N of one at a time: A little national survey on good death Mr. Stephen Jenkinson

Breakthrough pain – A thorn by any other name would be as sharp Dr. Carlo DeAngelis

Patient and Family Support Program: The first year Drs. Jeff Myers, Margaret Fitch, Ms.

Pat Brown Insert #1 February 2010

Exercise and breast cancer (Supported by an education grant from Pfizer) Dr. Teresa Petrella

Insert #2

February 2010 Targeting RANK-ligand in the treatment of bone metastases (Supported

by an education grant from Amgen)

Dr. Christine

Simmons Insert #3 February 2010

Treatment of chronic lymphocytic leukemia (CLL) in the untreated patient (Supported by an education grant from Roche)

Dr. Martina Trinkaus


From the guest editor‘s desk Ms. Lori Holden

Running care team meetings: A primer! Mr. Blair Henry

Providing person-centred cancer care Dr. Margaret Fitch

Predictors of place of death and family caregiver burden across the home-based palliative care trajectory

Drs. Denise Guerriere, Peter Coyte, Amna Husain, Denise Marshall

71

Current research on normal and complicated/prolonged grief Dr. Mary Vachon Insert May 2010

Stereotactic body radiotherapy for liver metastases

Surgical resection of colorectal liver metastases: An update (Supported by an education grant from Roche)

Dr. Hans Chung

Dr. Calvin Law



Humane end-of-life treatment conversations Dr. Monica Branigan

New trend: Survivorship care Dr. Margaret Fitch

Dysphasia and pill-taking in the oncology setting Dr. Carlo DeAngelis

2010 Annual Hospice Palliative Care Conference Ms. Florencia Jon

Panic in cancer patients: ―Fight or flight‖ Dr. Eileen La Croix

Sunny side up Mr. Matthew Mendonca


Breakthrough cancer pain: Assessment and management challenges

(Supported by an education grant from Valeant Canada Ltd.)

Dr. Lawrence Librach



Mitigating health care communication barriers: A legal, ethical and economic case for professional medical interpreters

Ms. Sally Bean

Palliative end-of-life home care and Chinese immigrants: The meaning of home and negotiations of care

Drs. Lisa Seto, Jan Angus, Doris Howell, Denise Gastaldo, and Amna Husain

Having and getting more life Dr. Michele Chaban

Opioid-induced hyperalgesia: When more is less Dr. Carlo DeAngelis

The multi-dimensional role of the clinical nutrition team at the Odette

Cancer Centre

Ms. Rosie Benson,

Elaine Posluns, Tracey Rapier, Edith Stokes, and Pauline Wisdom-Gilliam


Treatment of chronic lymphocytic leukemia in the elderly

(Supported by an education grant from Roche)

Dr. Matthew Cheung


HER2 testing and trastuzumab in advanced gastric and gastroesophageal cancer (Supported by an education grant from Roche)

Drs. Eugene Hsieh, Yoo-Joung Ko

Insert #3 November

2010

Cancer-associated venous thromboembolism NCCN clinical practice

guidelines – Update 2010 (Supported by an education grant from Pfizer)

Dr. Richard Jay


Systemic therapy for metastatic Renal Cell Carcinoma (mRCC) (Supported by an education grant from Novartis)

Drs. Sonal Gandhi, Georg Bjarnason

72

APPENDIX F [Back]

Undergraduate Teaching – Co-op Program

Programme Student Period

Fourth year student

University of Waterloo

Shaelyn Culleton 2008 - 2010

Third year student


Janet Nguyen 2009 – 2010

Second year student


Liang Zeng 2010

Third year student

McMaster University

Cassandra Uy 2010

Third year student

University of Western Ontario

Justin Kwong 2010

First year student

McMaster University

Karrie Wong 2010

First year medical student

University of Western Ontario

Esther Chan 2010

Second year student


Kaitlin Koo 2010

73

APPENDIX G

[Back]

Ongoing Research Studies in the Rapid Response Radiotherapy Program and the Bone Metastases Clinic

Study Titles

Examining Urinary Markers for Dexamethasone Metabolism, Inflammatory Cytokines and Bone Marker Turnover Following the Decadron Prophylaxis of

Pain Flare

Assessing quality of life in cancer patients receiving palliative radiotherapy for symptomatic lung cancer or lung metastases using the European

Organization for Research and Treatment of Cancer Lung Cancer Module (EORTC QLQ-LC13)

SC-20 A Phase III International Randomized Trial of Single Versus Multiple

Fractions for Re-irradiation of painful bone metastases (NCIC Clinical Trials Group)

SC-20U Effect of Re-Irradiation for bone pain on Urinary Markers of Osteoclast Activity --A companion study to SC 20

International Cross-Cultural Field Validation of an EORTC Questionnaire

Module for Patients with Bone Metastases (EORTC QLQ-BM22)

Examining Urinary Markers of Pain Flare in Patients Undergoing External Beam Radiotherapy in the Treatment of Bone Metastases

International Validation of the European Organization for Research and

Treatment of Cancer Brain Module (EORTC-QLQ-BN20) for Assessing Quality of Life in Patients with Brain Metastases

Assessing Quality of Life in Patients with Bone Metastases Using the

European Organization for Research and Treatment of Cancer Bone

Metastases Module (EORTC QLQ-BM22)

Prospective Analysis of Antiemetic Medication Prescribed for Radiation Induced Emesis for Patients seen in the Rapid Response Radiotherapy

Program (RRRP)

74

Assessing Quality of Life in Patients with Brain Metastases Using the

European Organization for Research and Treatment of Cancer Brain Module (EORTC QLQ-BN20)

Correlating Radiotherapy Response with Tumour Related Factors in Cancer

Patients with Bone Metastases to the Spine

Patient Expectation and Understanding of Palliative Radiotherapy Treatment at the RRRP: A Quantitative Survey

75

APPENDIX H: Report Submission for Knowledge Translation Casebook (in Association with Ontario Institute for Cancer Research, Canadian Partnership Against Cancer,

and McMaster University Health Sciences)

80

APPENDIX I

Emily Sinclair Written by Mark Hayes

Chances are you don't know what a Radiation Therapist does. Some people might envision a nurse that takes x-rays or perhaps (if you’re into science fiction), a cross between Darth Vader and Dr. Fraser Crane. According to the National Cancer

Institute, “Radiation therapy is the treatment of cancer and other diseases with ionizing radiation.” The therapist works with doctors, patients and all members of the hospital team to strategize and implement the destruction of malignant cells.

Emily Sinclair has been waging war on cancer for over 20 years. She graduated with a DCR(T) from the School of Radiotherapeutics and Oncology in Glasgow, Scotland. Shortly after graduation, Emily was headhunted by the Canadian Government, as Emily explains, "The wait list for cancer treatment in Canada was too high, so they sent scouts all around the world to bring in new talent." They offered Emily a one year contract and an exciting opportunity to move to a new country and put her new skillset to work. It's been over twenty years and she's still here.

Emily works as a radiation therapist at the Odette Cancer Centre in Toronto's Sunnybrook Hospital. On any given day, she can find herself doing anything from calculating the radiation dose and planning the patient’s treatment, preparing an isodose distribution to spare as much healthy tissue as possible, counselling patients and their families, or treating patients with the high-tech radiation

equipment with names that are near impossible to pronounce. Her role in the patient’s recovery is absolutely essential — remember, the doctor sees a patient once every two weeks, whereas Emily deals with them every day for 6 weeks straight.

Emily is the recipient of multiple awards, but perhaps the most prestigious is a recent Academic Appointment at the University of Toronto's Department of Radiation Oncology within the Faculty of Medicine. She was awarded this honour for her significant contribution and dedication to her field of study; as a result, she contributes to the world of academia by writing manuscripts and lecturing both locally and across the world.

Aside from the obvious challenges Emily faces on a daily basis, she wants to raise awareness to difficulties facing her discipline at large, stating, “The salaries aren’t great, but our qualifications have to be.” Most radiation therapists have at least 7 years of post-secondary education under their belt, but their pay levels don’t represent two degrees, “Many good Radiation Therapists move on to drug companies or medical tech manufacturers — we can’t compete with the salaries they offer.” Through Emily’s efforts with the Canadian Association of Medical Radiation Technologists (CAMRT) and her union the Professional Institute of the Public Service of Canada (PIPSC), she fights for the strength of her profession which ultimately contributes to the betterment of public health and society at large.

http://www.ottawalife.com/index.php?option=com_content&view=article&id=465:emily-

sinclair&catid=74:public-service&Itemid=100018

http://www.ottawalife.com/index.php?option=com_content&view=article&id=465:emily-sinclair&catid=74:public-service&Itemid=100018

http://www.ottawalife.com/index.php?option=com_content&view=article&id=465:emily-sinclair&catid=74:public-service&Itemid=100018

january december 2010 - sunnybrook hospitalkristin harris (in clinic 2005 – 2006), medical...

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