Jemma Gatliff Future Health Summit

Dublin, May 2016

   •  Overview of Keregen Therapeutics •  Our Journey •  Accelerator programs •  Aligning with academia

àUK-based early stage drug discovery and àdevelopment company

àUCL School of Pharmacy Start-up/Future Spin-out

àFounded in 2015

àOperating out of UCL/Stevenage Bioscience Catalyst

Keregen Therapeutics:

GEOFF WELLS, Chair of SAB

Management Team

JEMMA GATLIFF, CEO NICK GEORGAKOPOULOS, CSO

Industry Advisors

ILAN ZIPKIN Takeda Ventures Inc. SAM FAZELI Bloomberg ANDY SANDHAM Bicycle Therapeutics/ 14M Genomics KEITH POWELL Canbex Therapeutics ROD PORTER Rod Porter Consulting

Scientific Partners

ALBENA DINKOVA-KOSTOVA University of Dundee BIRGITT SCHUELE Parkinson’s Institute, CA JEFF JOHNSON University of Wisconsin KENNETH SMITH Institute of Neurology, UCL TILO KUNATH University of Edinburgh

àFirst-in-class non-covalent small àmolecule Nrf2 activators

àDisease modifying therapeutic àintervention in Parkinson’s

àSafety profile – better or equal to àmarketed symptomatic therapy

àOral once daily route of àadministration

Target Product Profile:

Developing precision medicines for patients with

high unmet clinical need

PATIENT FOCUS •  More than five million

people worldwide have Parkinson’s Disease

•  Long-term progressive illness

•  No disease-modifying treatments

MULTIDISCIPLINARY UNIT •  Structure-based drug

design to proof-of-concept biological validation

R&D DRIVERS •  Targets with genetic

evidence are more successful in drug discovery

   •  Overview of Keregen Therapeutics •  Our Journey •  Accelerator programs •  Aligning with academia

The journey so far…

2012/13:  Nick  begins  PhD  with  Geoff.  Jemma  meets  Nick    

2014:  Enter  OneStart  

Feb  –  May  15:  Mentoring  from  Ilan  Zipkin  and  others  from  OneStart  

May  15:  Winners  of  OneStart  £100k  prize  

Oct  16  Full-­‐Sme  Keregen  

Jan  16  –    Early  for  market  à  Falls  outside  typical  TTO  model  à  UCL/SBC  incubator  

March-­‐April  16:  4  new  FTEs  

Dec  16  –  Keregen  Incorporated  

May  16:  Move  to  SBC  

Accelerator Programs

BUILD A NETWORK •  Advisors and champions

are essential

•  Get advice from experienced people

•  It takes many people to

build a company e.g. finance, legal, scientists, HR

LEARN THE LINGO •  Equip yourself with

business terminology •  Understand the market

opportunity

•  Where does your product fit in?

PITCH PERFECT •  Develop your business

plan

•  1 min, 3 min, 5 min, 20 min pitches

Aligning with academia early on

WORK SPACE •  Universities have start-

up space e.g. UCL & Cambridge @ SBC

•  Access to equipment

•  Existing infrastructure

RECRUITING GROUND •  Stay in the loop with

academic research

•  Highly skilled personnel on your door step

MAXIMISE •  Non-dilutive funding

opportunities

•  Collaborative projects: continued pipeline