john a. belperio, m.d. personal history belperio class cv 12 05.pdf · undergraduate training: 1983...

JOHN A. BELPERIO, M.D.

CURRICULUM VITAE

PERSONAL HISTORY:

BUSINESS ADDRESS: Division of Pulmonary and Critical Care Medicine David Geffen School of Medicine at UCLA 900 Veteran Ave., 14-154 Warren Hall, Box 711922 Los Angeles, CA 90024-1922 Phone: (310) 794-1999 Date of Birth: 08/19/1966 Place of Birth: Philadelphia, PA Citizenship: USA Marital Status: Married

EDUCATION:

Undergraduate Training: 1983 – 1985 Community College of Philadelphia, A.S., Engineering

1985 – 1988 Drexel University, B.S., Chemical Engineering Medical School: 1990 – 1994 Temple University School of Medicine

Postdoctoral Training

1994 - 1995 Medical Internship: University of Maryland Medical Center, Baltimore, Maryland

1995 – 1997 Medical Residency: University of Maryland Medical Center, Baltimore, Maryland

1997 – 2000 Pulmonary and Critical Care Fellowship: University of Michigan Medical Center, Ann Arbor, Michigan

LICENSURE:

1994 - 1997 State of Maryland 1997 - 2000 State of Michigan 2000 - State of California, Medical License #A72669 2000 - California Fluoroscopy operator and supervisor permit

CERTIFICATION:

1997 Internal Medicine 1999 Pulmonary Medicine 2000 Critical Care Medicine

PROFESSIONAL EXPERIENCE:

2

7/01/00 - Clinical Instructor, UCLA School of Medicine, Center for Health Science, Los Angeles, California

9/14/00 - Co-Chair of the Pulmonary and Critical Care Resident Educational Committee

9/14/00 - Co-Chair of the Pulmonary and Critical Care Fellow Educational Committee

11/1/00 - Co-Chair of the UCLA Annual Update of Pulmonary and Critical Care Course

7/01/01 - Assistant Professor, UCLA School of Medicine, Center for Health Science, Los Angeles, California

7/01/07 - Associate Professor, UCLA School of Medicine, Center for Health Science, Los Angeles, California

PROFESSIONAL ACTIVITIES:

3/97 Planning group for multidisciplinary Asthma pathways, University of Maryland Medical Center

1997 - American Thoracic Society 1997 - American College of Chest Physicians 2000 Reviewer “American Journal of Physiology: Lung Cellular and

Molecular Physiology” 2001 Reviewer “Journal of Applied Physiology” 2002 Chairman for the First Annual UCLA Update in Pulmonary and

Critical Care course” 2002 Morning Mortality Committee 2003 Chairman for the Second Annual UCLA Update in Pulmonary and

Critical Care course” 2004 Co-Chairman for the Third Annual UCLA Update in Pulmonary

and Critical Care course” 2005 Co-Chairman for the Fourth Annual UCLA Update in Pulmonary

and Critical Care course” 2006 Co-Chairman for the Fourth Annual UCLA Update in Pulmonary

and Critical Care course” 2007

HONORS AND PRESENTATIONS:

Undergraduate Level: 1988 Dean’s List, Community College of Philadelphia 1988 Dean’s List, Drexel University 1988 Outstanding Senior Design Project of the Year, Drexel University

Postgraduate Level:

11/95 Offered the position of Chief Medical Resident at Mercy Medical Center (University of Maryland adjunct training program)

10/96 Offered the position of Chief Medical Resident at the University Maryland Medical Center, Declined to begin Pulmonary and Critical Care Fellowship

4/97 Inducted into the Alpha Omega Alpha Society 6/97 Awarded Most Outstanding Resident at the University Maryland

Medical Center class of 1997

3

6/2001 Nominated for 2000-2001 Full Time Faculty Teaching Award. 2001-2002 Full Time Faculty Teaching Award at the David Geffen-School of Medicine, Los Angeles, CA (voted by the Medical House staff)

5/08/02 2001-2002 Physician of the year Award at the David Geffen-School of Medicine, Los Angeles, CA (voted by the Nursing staff).

6/07/03 2002-2003 Physician of the year Award at the David Geffen-School of Medicine, Los Angeles, CA (voted by the Medical House staff).


5/14/05 Nominated for 2004-2005 Full Time Faculty Teaching Award. 2001-2002 Full Time Faculty Teaching Award at the David Geffen-School of Medicine, Los Angeles, CA (voted by the Medical House staff)


6/2007 Nominated for 2006-2007 Full Time Faculty Teaching Award. 2001-2002 Full Time Faculty Teaching Award at the David Geffen-School of Medicine, Los Angeles, CA (voted by the Medical House staff)

6/2008 Runner up for 2007-2008 Full Time Faculty Award by the Nurses. David Geffen-School of Medicine, Los Angeles, CA (voted by the Nursing staff)

RESEARCH GRANTS AND FELLOWSHIPS RECEIVED:

07/99-06/00 Glaxo Wellcome Pulmonary Fellowship Award, $40,000, Principal Investigator John Belperio

02/01/01-01/31/06 NIH, KO8, Mentored Research Career Award, $500,000.00 directs, 1R01HL080206-01.

7/2001-7/2002 Stein Oppenheimer Research Award, $35,000, Principal Investigator John Belperio.

5/2001-5/2002 Ortho Biotech Educational Award, $1,500, Principal Investigator John Belperio.

07/01/01-07/31/03 National and California State ALA Mentored Research Career Award, $70,000.00 directs, Principal Investigator John Belperio.

06/01/05-06/01/10 NIH, 1R01HL080206-01, The Role of Chemokines During Lung Allograft Dysfunction

LECTURES AND PRESENTATIONS:

5/15/97 Lecturer, Clinical Conference, Pulmonary Division University of Michigan, “Pathogenesis and Treatment of BOOP”

6/27/97 Lecturer, Research Conference, Pulmonary Division University of Michigan, “The role of CC Chemokines in Acute Rejection”

8/10/97 Lecturer, Research Conference, Pulmonary Division University of Michigan, “MCP-1 and its association with Acute Lung Allograft Rejection”

4/20/98 Lecturer, Research Conference, Pulmonary Division University of Michigan, “The role of IL-13 in Asthma”

4

5/7/98 Lecturer, Clinical Conference, Pulmonary Division University of Michigan, “The Role of the HRCT in IPF”,

6/22/98 Lecturer, Clinical Conference, Pulmonary Division University of Michigan, “CMV and Transplantation”,

3/19/99 Lecturer, Research Conference, Pulmonary Division University of Michigan, “The role of Met-RANTES in Transplantation”,

4/19/00 Lecturer, Clinical Conference, Pulmonary Division University of Michigan, “Wegener’s Granulomatosis”

6/10/00 Lecturer, Research Conference, Pulmonary Division University of Michigan, “Elevated levels of MCP-1 are associated with BOS”,

7/25/00 Lecturer, Research Conference, Pathology Division University of California, Los Angeles, “Chemokines and Lung Transplantation”,

8/15/00 Lecture, UCLA Critical Care Teaching Seminar. “Chemokines and Lung Allograft Rejection”,

9/01/00 Lecturer, Critical Care Conference, Pulmonary and Critical Care Division “Mechanical Ventilation in the ICU”,

9/26/00 Morning report discussion “Neuro-Sarcodosis”, UCLA Medical Center,

11/14/00 Lecturer, Critical Care Conference, Pulmonary and Critical Care Division “Electrolytes in the ICU”,

11/15/00 Clinicopathological Conference, Internal Medicine Grand Rounds, 11/16/00 Pulmonary and Critical Care Grand Rounds, “Chemokines and

Lung Transplantation”, 12/20/00 Lecturer, Clinical Conference, Internal Medicine Division UCLA

Medical Center, “Ventilators in the ICU”, 12/27/00 Lecturer, Clinical Conference, Internal Medicine Division UCLA

Medical Center, “Asthma in the ICU”, 1/03/01 Lecturer, Clinical Conference, Internal Medicine Division UCLA

Medical Center, “Pressors in the ICU”, 1/10/01 Lecturer, Clinical Conference, Internal Medicine Division UCLA

Medical Center, “IPF and Sarcoid”, 1/12/01 Lecturer, Clinical Conference, Internal Medicine Division UCLA

Medical Center, “COPD in the ICU”, 1/21/01 Lecturer, Clinical Conference, Internal Medicine Division UCLA

Medical Center, “Acid-Base in the ICU”, 2/2/01 Lecturer, Clinical Conference, Internal Medicine Division UCLA

Medical Center, “Mechanical Ventilators in the ICU”, 2/12/01 Lecturer, Clinical Conference, Medical School Second year Class

UCLA Medical Center, “Pulmonary Pathophsiology”, 2/13/00 Morning report discussion “TB-Effusion”, UCLA Medical Center, 2/13/01 Lecturer, Pulmonary Clinical Conference, Medical School UCLA

Medical Center, “BOOP”, 2/26/01 Lecturer, Internal Medicine Clinical Conference, Medical School

UCLA Medical Center, “Pleural Effusions”, 2/27/01 Lecturer, Clinical Conference, Internal Medicine Division UCLA

Medical Center, “Mechanical Ventilators Weaning”, 3/5/01 Pathological Case Conference, Internal Medicine Report, “PE,

Pneumonia, and Interstitial Lung Disease” 3/20/01 Lecturer, Clinical Conference, Internal Medicine Division UCLA

Medical Center, “Proning and Oxygenation on the Ventilator”, 4/16/01 Lecturer, Clinical Conference, Internal Medicine Division UCLA

Medical Center, “Electrolytes in the ICU”,

5

4/17/01 Lecturer, Clinical Conference, Surgery Division UCLA Medical Center, “Peri-Operative Pulmonary Complication”,

4/25/01 Lecturer, Conference, Medical School UCLA Medical Center, “Choosing a Career in Medicine”,

5/14/01 Lecturer, Research Conference, Pathology Division University of California, Los Angeles, “Protective “Low-Stretch” Mechanical Ventilation is Associated with Lower Levels of MIP-2 and KC as Compared to Injurious “High-Stretch” Mechanical Ventilation in a murine Model of Ventilator-Induced Lung Injury”,

7/12/01 Junior Resident Rounds, Internal Medicine, “TB, Palsy, Lung Cancer”,

7/12/01 Lecturer, Clinical Conference, Surgery Division UCLA Medical Center, “Pre-Operative Pulmonary Evaluation for Surgery”,

8/6/01 Pathological Case Conference, Internal Medicine Report, “PCP Pneumonia, and ARDS”

7/28/01 Morning report discussion “Small Cell Lung Cancer and Paraneoplastic syndromes”, UCLA Medical Center,

8/14/01 Morning report discussion “SIADN and Hyponatremia”, UCLA Medical Center,

8/14/01 Lecturer, Clinical Conference, Internal Medicine Division UCLA Medical Center, “Mechanical Ventilation”,

9/4/01 Lecturer, Clinical Conference, Internal Medicine Division UCLA Medical Center, “Electrolytes in the ICU”,


9/14/01 Well Being Dinner for First and Second year medical student. Medical School UCLA Medical Center “Getting through the first set of exams”

10/1/01 Grand Rounds, Internal Medicine VA of Los Angeles, “Lung Transplantation”,

10/3/01 Lecturer, Clinical Conference, Surgery Division UCLA Medical Center, “Pre-Operative Pulmonary Evaluation for Surgery”,

10/4/01 Grand Rounds, Pulmonary and Critical Care Medicine VA of Los Angeles, “Pleural Effusions”,

10/4/01 Lecturer, Clinical Conference, Internal Medicine Division UCLA Medical Center, “Mechanical Ventilation-Part I”,

10/9/01 Lecturer, Clinical Conference, Internal Medicine Division UCLA Medical Center, “Mechanical Ventilation-Part II”,

10/23/01 Morning report discussion “Sepsis and Septic Shock Syndrome”, UCLA Medical Center,

10/25/01 Well Being Dinner for First and Fourth year medical student. Medical School UCLA Medical Center “The Future Hold Promise”


11/6/01 Lecturer, Clinical Conference, Internal Medicine Division UCLA Medical Center, “COPD”,

11/9/01 Noon Conference Medical Rounds, Internal Medicine Division UCLA Medical Center, “Pleural Effusions”,

11/20/01 Morning report discussion “Ascites”, Internal Medicine Division UCLA Medical Center

12/4/01 Lecturer, Clinical Conference, Internal Medicine Division UCLA Medical Center, “Mechanical Ventilation”

6

12/16/01 Intermune preceptorship on “Pulmonary Fibrosis Signs, Symptoms, Pathophsyology, PFTS, Treatment”

1/09/02 Lecturer, Clinical Conference, Surgery Division UCLA Medical Center, “Pre-Operative Pulmonary Evaluation for Surgery”

1/22/02 Well Being Dinner for 1st year medical student. “The Intern Year” UCLA Medical Center

1/24/02 Lecturer, Clinical Conference, Internal Medicine Division UCLA Medical Center, “Mechanical Ventilation”

1/31/02 Lecturer, Clinical Conference, Internal Medicine Division UCLA Medical Center, “ARF”

1/9/02 Noon Conference Medical Rounds, Internal Medicine Division UCLA Medical Center, “Wegeners Granulomatoous”

2/12/02 Lecturer, Clinical Conference, Medical School Second year Class UCLA Medical Center, “Pulmonary Pathophsiology II”

2/19/02 Lecturer, Clinical Conference, Medical School Second year Class UCLA Medical Center, “Pulmonary Pathophsiology II”

3/11/02 Morning report discussion “Histoplasmosis”, Internal Medicine Division UCLA Medical Center

3/27/02 Lecturer, Clinical Conference, Internal Medicine Division UCLA Medical Center, “ALI/ARDS”

3/28/02 Lecturer, Clinical Conference, Internal Medicine Division UCLA Medical Center, “nosocomial pneumonia”

4/01/02 Lecturer, Clinical Conference, Internal Medicine Division UCLA Medical Center, “COPD”

4/02/02 Lecturer, Clinical Conference, Internal Medicine Division UCLA Medical Center, “PPH”

4/05/02 Lecturer, Clinical Conference, Internal Medicine Division UCLA Medical Center, “Ventilator Management”



4/19/02 Lecturer, Conference, Medical School UCLA Medical Center, “Choosing a Career in Medicine”

5/14/02 Morning report discussion “Secretors vs Osmotic Diarrhea”, Internal Medicine Division UCLA Medical Center




7/10/02 Morning report discussion “Hypernatremia”, Internal Medicine Division UCLA Medical Center



9/16/02 Lecturer, Clinical Conference, Internal Medicine Division UCLA Medical Center, “ICU Electrolytes”


11/17/02 Lecturer, Clinical Conference, Internal Medicine Division UCLA Medical Center, “Mechanical Ventilation in the ICU”, 1/09/01

7

1/09/03 Lecturer, Clinical Conference, Internal Medicine Division UCLA Medical Center, “Mechanical Ventilation in the ICU”,


1/08/02 Lecturer, Clinical Conference, Surgery Division UCLA Medical Center, “ARDS”

1/21/02 Well Being Dinner “How to become a Resident”, Medical school at UCLA

1/22/02 Lecturer, Clinical Conference, Surgery Division UCLA Medical Center Lung transplantation lecture “Thymoma and Lung transplantation”.

1/23/02 UCLA Morning Mortality “Natremia” 2/03/03 Lecturer, Clinical Conference, Internal Medicine Division UCLA

Medical Center, “Ventilator Management” 2/06/03 Pathophysiology of Disease “Acute respiratory Failure” UCLA

school of medicine Second Year Class 2/10/03 Pathophysiology of Disease “Acute respiratory Failure Part II

Hypercapnia” UCLA school of medicine Second Year Class 2/11/03 Pathophysiology of Disease “Respiratory Failure” UCLA school of

medicine Second Year Class 2/11/03 Morning Report at UCLA internal medicine. 2/18/03 Pathophysiology of Disease “Respiratory Failure and emphysema

and ILD” UCLA school of medicine Second Year Class 2/23/03 Lecturer, Clinical Conference, Internal Medicine Division UCLA

Medical Center, “Mechanical Ventilation in the ICU”, 2/24/03 Lecturer, Clinical Conference, Internal Medicine Division UCLA

Medical Center, “Swan-Ganz Catheter in the ICU”, 3/07/03 Pulmonary Grand Round “Pleural Effusion State of the Art”

Clinical Conference, Internal Medicine Division UCLA 3/13/03 Senior Report at UCLA, Dept of Interanal Medicine 3/14/03 Lecturer, Clinical Conference, Internal Medicine Division UCLA

Medical Center, “ALI/ARDS” 4/08/03 Morning Report at UCLA Internal Medicine Division UCLA

Medical Center,.”Bronchectasis” 4/16/03 Lecturer, Clinical Conference, Surgery Division UCLA Medical

Center, “ARDS and per-operative pulmonary evaluation” 4/17/03 UCLA, Morning Mortality “Heart failure and COPD” 5/12/03 Lecturer, Clinical Conference, Internal Medicine Division UCLA

Medical Center, “Wegeners- Current Concepts”” Clinical Conference, Internal Medicine Division UCLA

7/08/03 Morning Report at UCLA Internal Medicine Division UCLA Medical Center,.”Diarrheia”

7/10/03 Lecturer, Clinical Conference, Surgery Division UCLA Medical Center, “Hospital Acquired Pneumonia and ARDS”

7/14/03 Lecturer, Clinical Conference, Internal Medicine Division UCLA Medical Center, “Mechanical Ventilation in the ICU”,

7/15/03 Morning Report at UCLA Internal Medicine Division UCLA Medical Center,.”Pneumonia”

7/22/03 Morning Report at UCLA Internal Medicine Division UCLA Medical Center,.”Cocci Pneumonia”

7/24/03 Morbidity and Mortality UCLA Internal Medicine Division UCLA Medical Center,.”When to monitor patients and Siezures”

8/19/03 Lecturer, Clinical Conference, Surgery Division UCLA Medical Center, “Ventilators”

8

8/21/03 Lecturer, Clinical Conference, Surgery Division UCLA Medical Center, “Pressors in the ICU”

8/28/03 Morbidity and Mortality UCLA Internal Medicine Division UCLA Medical Center,.”Subepidural Empyema”

9/09/03 Lecturer, Clinical Conference, Internal Medicine Division UCLA Medical Center, “Pleural Effusion Part II”,

9/23/03 Morning Report at UCLA Internal Medicine Division UCLA Medical Center,.”ILD-UIP/IIP”

9/24/03 Morbidity and Mortality UCLA Internal Medicine Division UCLA Medical Center,.

9/25/03 Lecturer, Clinical Conference, Ambulatory Medicine Division UCLA Medical Center, “Obstructive Airways Disease”


10/14/03 Junior Residence evening report Internal Medicine Division UCLA Medical Center,

10/23/03 Morbidity and Mortality UCLA Internal Medicine Division UCLA Medical Center,.”Anti-Coagulation”

10/28/03 Lecturer, Clinical Conference, Internal Medicine Division UCLA Medical Center, “Community acuired pneumonia”


12/3/03 First year Medical School Lecture Pulmonary Physiology “Acute Hypercapnic Respiratory Failure”

12/3/03 First year Medical School Lecture Pulmonary Physiology “Acute andChronic Congestive Heart Failure: Body Fluids and The Lungs”

12/4/03 First year Medical School Lecture Pulmonary Physiology “Pulmonary Diagnostic Techiques”

12/4/03 First year Medical School Lecture Pulmonary Physiology “Acid-Base”

12/5/03 First year Medical School Lecture Pulmonary Physiology “Case Studies “Respiratory Failure”

12/5/03 First year Medical School Lecture Pulmonary Physiology “General Pulmonary Review”


12/9/03 Senior Residence evening report Internal Medicine Division UCLA Medical Center,


1/27/04 Lecturer, Clinical Conference, Medical Division UCLA Medical Center, “Pressors in the ICU”

2/5/04 Second year Medical School Lecture Pulmonary Physiology “Hypoxemic Respiratory Failure ands ARDS”

2/9/04 Second year Medical School Lecture Pulmonary Physiology “Hypercapnic Respiratory Failure”


2/26/04 Morbidity and Mortality UCLA Internal Medicine Division UCLA Medical

3/04/04 Morning Report UCLA Internal Medicine Division UCLA Medical Center


9


4/04/04 Afternoon MKSAP Pulmonary Review UCLA Internal Medicine Division UCLA Medical Center



4/15/04 Lecturer, Clinical Conference, Nursing Division UCLA Medical Center, “CAP, COPD and PE”






7/12/04 Lecturer, Noon Clinical Conference, Medical Division UCLA Medical Center, “Pleural Effusion I”

7/12/04 Lecture PILOT program for interstial lung disease – BOOP and IPF at UCLA fauculty center

7/15/04 Lecturer, Noon Clinical Conference, Medical Division UCLA Medical Center, “Pleural Effusion II”



8/03/04 Lecturer, Clinical Conference, Medical Division UCLA Medical Center, “Ventilator Management in the ICU”

8/04/04 Lecturer, Clinical Conference, Medical Division UCLA Medical Center, “Hypoxemia in the ICU”

8/04/04 Lecturer, Primary Care College Conference, Medical Division UCLA Medical Center, “Oxygen deliver and mechanical ventilation in the ICU”




8/31/04 Lecturer, Clinical Conference, Surgery Division UCLA Medical Center, “Pre-op Pulmonary and Ventilators”

9/11/04 Lecturer, Acute Care College Conference, Medical Division UCLA Medical Center, “Oxygen deliver and mechanical ventilation in the ICU and hemodynamic monitoring”



10/10/04 Lecturer, Clinical Conference, Nursing Division UCLA Medical Center, “Pneumonia, VTE and COPD”

10





12/3/04 First year Medical School Lecture Pulmonary Physiology “Acute and Chronic Congestive Heart Failure: Body Fluids and The Lungs”



12/10/04 First year Medical School Lecture Pulmonary Physiology “Case Studies “Respiratory Failure”






3/2/05 Second Year Medical Students Clinical Pathophysiology Course “Acute Hypoxic and Hypercapnic Respiratory failure”.

3/15/05 Third Year Medical Students Clinical Pathophysiology Course “Acute Hypoxic and Hypercapnic Respiratory failure”.

4/12/05 Residency Board review of Critical Care. 4/15/05 Journal Club for the pulmonary and critical car fellowship on

Asthma. 4/28/05 Internal Medicine Morbidity and Mortality. 4/28/05 Lecturer, Clinical Conference, Surgery Division UCLA Medical

Center, “Pre-op Pulmonary and Ventilators” 5/03/05 Lecturer, Clinical Conference, Surgery Division UCLA Medical

Center, “Pre-op Pulmonary and Ventilators” 6/13/05 Lecturer, Clinical Conference, Medical Division UCLA Medical

Center, “Pressors in the ICU” 6/17/05 Internal medicine Morning Report 7/12/05 Lecturer, Clinical Conference, Medical Division UCLA Medical

Center, “Pressors in the ICU” 7/14/05 Third Year Medical Students Clinical Pathophysiology Course

“Acute Hypoxic and Hypercapnic Respiratory failure”. 8/02/05 Acute Care College Teaching Seminar 8/03/05 Acute Care College Teaching Seminar 8/08/05 Lecturer, Clinical Conference, Medical Division UCLA Medical

Center, “Pressors in the ICU” 9/06/05 Lecturer, Clinical Conference, Medical Division UCLA Medical

Center, “Pressors in the ICU” 10/06/05 Lecturer, Clinical Conference, Medical Division UCLA Medical

Center, “Pressors in the ICU”

11


11/30/05 First year Medical School Lecture Pulmonary Physiology “Acute and Chronic Congestive Heart Failure: Body Fluids and The Lungs”



12/02/04 First year Medical School Lecture Pulmonary Physiology “Case Studies 1 “Respiratory Failure”

12/02/05 First year Medical School Lecture Pulmonary Physiology “Spirometry Lab”

12/03/05 First year Medical School Lecture Pulmonary Physiology “Case Studies 2 “Respiratory Failure”


12/03/05 First year Medical School Lecture Pulmonary Physiology “Control of breating lab”

















7/20/06 Lecturer, Clinical Conference, Nursing Division UCLA Medical Center, “Respiratory Failure”

12










11/08/06 Lecturer, Clinical Conference, Medical Division UCLA Medical Center, “Sepsis in the ICU”

11/09/06 Lecturer, Clinical Conference, Medical Division UCLA Medical Center, “Lung Transplantation in the ICU”

11/10/06 Lecturer, Clinical Conference, Medical Division UCLA Medical Center, “Ventilators-Part I in the ICU”

11/11/06 Lecturer, Clinical Conference, Medical Division UCLA Medical Center, “Ventilators-Part II in the ICU”




EXTRAMURAL INVITED PRESENTATIONS National

5/30/00 Invited Speaker, “Elevated Levels of MCP-1 are associated with

Bronchiolitis Obliterans Syndrome, a fibrotic disease of the small airways.” Conference on Mechanisms of Pulmonary Fibrosis. Thomas L. Petty Aspen Lung Conference 43rd annual meeting.,

9/00 Invited Speaker, “Pleural Effusions”. Kern Medical Center, Bakersfield, CA.

5/14/01. Invited Editor, “Medical Diary of Lung Transplantation.” 6/16/01 Invited Speaker, “Critical Role of MCP-1/CCR2 Biology During

the Pathogenesis of BOS.” Conference For young leaders in pulmonary medicine 1st annual meeting., .

10/1/01 Medical Grand Rounds, Internal Medicine VA of Los Angeles, “Chemokines and Lung Transplantation”,

13

10/4/01 Board Review, Pulmonary Fellows “Pleural Effusions”, West Los Angeles VA

12/6/01 Invited Speaker, “Critical Role of Chemokines During the Pathogenesis of BOS.” Stien Oppenheimer Conference UCLA Medical Center,

4/21/02 Invited Speaker, “Critical Role of CXCR3 During the Pathogenesis of Acute Lung Allograft Rejection.” FASEB Conference New Orleans

5/13/02 Invited Speaker, “Critical Role of IL-10 During the Pathogenesis of Acute Lung Allograft Rejection.” 7th Annual Gene Therapy Symposium, Loss Angeles California, UCLA Medical Center,

5/20/02 Invited Speaker, “Chemokine Biology During the Pathogenesis of Acute and Chronic Rejection.” ATS Transplantation Symposium Atlanta Georgia

8/28/02 Invited Speaker, “Chemokine Biology During the Pathogenesis of Acute and Chronic Rejection.” Medical Grand Round at UCLA.

9/19/02 Invited Speaker, “Critical Role of CXCR2 Biology During Ventilator induced Lung Injury”, University of Vermont

10/05/02 Inviter Speaker, “Pleural Diseases”, Los Angels, CA VA Department of Pulmonary and Critical Care

10/19/02 Invited Speaker, “Chest X-Ray Interpretation”, National Meeting of Nurse Practitioners, LA, CA

05/01/02 Invited Speaker, “Role of Chemokines during the Pathogenesis of Acute and Chronic (BOS) Lung Allograft Rejection”, Fairfax hospital pulmonary medical grand rounds, Fairfax Virginia,

05/02/02 Invited Speaker, “Role of Chemokines during the Pathogenesis of Acute and Chronic (BOS) Lung Allograft Rejection”, John Hopkins Hospital Pulmonary Medical Grand Rounds, Balto., MD

05/18/02 Facilitator Lung Transplantation I at ATS 2003 Washington State Convention/Trade Center, Seattle Washington.

05/21/02 Invited Speaker, “Role Of TARC/MCD during the pathogenesis of Pulmonary Fibrosis” ATS 2003 Washington State Convention/Trade Center, Seattle Washington.

05/21/02 Invited Speaker, “Role Of IL-10 during the pathogenesis of Acute Lung Allograft Rejection” ATS 2003 Washington State Convention/Trade Center, Seattle Washington.

07/09/03 Invited Speaker, “Community Acquired and Hospital Acquired Pneumonia” ACP 2003 Los Angeles CA/Universal Hilton Center, LA CA

11/21/03 Invited Speaker, “Role of Chemokines during the Pathogenesis of Acute and Chronic (BOS) Lung Allograft Rejection”, University of Pennsylvania Philadelphia, Pennsylvania Pulmonary Medical Grand Rounds, Balto., MD

11/22/03 Invited Speaker, “Role of Chemokines during the Pathogenesis of Acute and Chronic (BOS) Lung Allograft Rejection”, Temple University Philadelphia, Pennsylvania Pulmonary Medical Grand Rounds, Balto., MD

14

1/12/04 Invited Speaker, “Role of Chemokines during the Pathogenesis of Acute and Chronic (BOS) Lung Allograft Rejection”, Seirei Hamamatsu Hospital, Shizuoka, Japan

1/13/04 Invited Speaker, “Pleural Effusion – What You Need to Know”, Seirei Hamamatsu Hospital, Shizuoka, Japan

1/14/04 Invited Speaker, “Community Acquired Pneumonia”, Seirei Hamamatsu Hospital, Shizuoka, Japan

1/18/04 Invited Speaker, “Role of Chemokines during the Pathogenesis of Acute and Chronic (BOS) Lung Allograft Rejection”, Asahi Hospital, Asahi, Japan

1/19/04 Invited Speaker, “Community Acquired Pneumonia”, Asahi Hospital, Asahi, Japan

1/20/04 Invited Speaker, “Pleural Effusions”, Asahi Hospital, Asahi, Japan 1/23/04 Invited Speaker, “Role of Chemokines during the Pathogenesis of

Acute and Chronic (BOS) Lung Allograft Rejection”, Chiba University Hospital, Chiba, Japan

4/22/04 Invited Speaker, “Role Of CC chemokines during the pathogenesis of BOS” FASEB 2004 Washington DC Convention/Trade Center, Washington DC

5/22/04 Invited Speaker, “Role Of Chemokines during the Pathogenesis of IPS” ATS 2004 Orlando Convention/Trade Center, Orlando Florida.

5/24/04 Invited Facilitator, “Lung Transplantation” ATS 2004 Orlando Convention/Trade Center, Orlando Florida.

5/25/04 Invited Speaker, “Treatment and Pathogenesis of BOS” ATS 2004 Orlando Convention/Trade Center, Orlando Florida.

3/14/05 Invited Speaker, “Role of Chemokines during the Pathogenesis of Lung Allograft Dysfunction”, University of Indiana, Indianapolis, Indiana, Pulmonary Medical Grand Rounds.

4/15/05 Invited Speaker, “Role of Chemokines during the Pathogenesis of Lung Allograft Dysfunction”, UCLA, LA, CA, Pulmonary Medical Grand Rounds.

4/22/05 Invited Speaker, “Diagnosis IPF/UIP/IIP”, UCLA, LA, CA, ILD Patient Seminar.

4/22/05 Invited Speaker, “Pulmonary Hypertension and IPF/UIP/IIP”, UCLA, LA, CA, ILD Patient Seminar.

5/24/05 Invited Speaker, “Lung Transplantation: Humors, Regulation, Tolerance, and Survival Lessons Learned from Animal Models of Lung Rejection” ATS 2005 San Diego

6/03/05 Invited Speaker, “Role of Chemokines and angiogenesis during the pathogenesis of lung cancer, chronic rejection and pulmonary fibrosis”. 10th EHA Congress will be organized in Stockholm, Sweden from June 2-5, 2005

6/22/05 Invited Speaker, UCLA Medical Grand Rounds, “Role of Chemokines during the pathogenesis of Lung Allograft dysfunction”.

15

6/12/06 Invited Speaker, UCLA Medical Grand Rounds, “Role of Chemokines during the pathogenesis of Lung Allograft dysfunction”

4/21/06 Invited Speaker, California VA Medical Grand Rounds, “Role of Chemokines during the pathogenesis of Lung Allograft dysfunction”.

7/ 02/06 Invited Speaker, USC Pulmonary and Critical Care Grand Rounds, “Role of Chemokines during the pathogenesis of Lung Allograft dysfunction”.

10/11/06 DOM day presentation “Role of IL-13 during BOS” 11/16/06 Invited Speaker, Harbor/UCLA Pulmonary and Critical Care Grand

Rounds, “Role of Chemokines during the pathogenesis of Lung Allograft dysfunction”.















6/30/08 Lecturer, Clinical Conference, Medical Division UCLA Medical

Center, “Pressors in the ICU” 7/01/08 Lecturer, Clinical Conference, Surgery Division UCLA Medical

Center, “Pre-Operative Pulmonary Evaluation for Surgery” 7/02/08 Lecturer, Clinical Conference, Medical Division UCLA Medical

Center, “Ventilators” 7/03/08 Lecturer, Clinical Conference, Medical Division UCLA

Medical Center, “Respiratory Failure” 7/04/08 Morning Report UCLA Internal medicine

16


4/12/07 Invited Speaker, International Society of Heart and Lung Transplantation, “Role of Chemokines during the pathogenesis of Lung Allograft dysfunction”.

10/18/07 Invited Speaker, Johns Hopkins Transplantation Grand Rounds, “Role of Chemokines during the pathogenesis of Lung Allograft dysfunction”.

2/18/08 Invited Speaker, Univ. of Chicago Grand Rounds, “Role of Chemokines during the pathogenesis of Lung Allograft dysfunction”.

4/15/08 Invited Speaker, Univ. of Virginia Medical Rounds, “Role of Type 2 Cytokines/Chemokines during the pathogenesis of BOS”.

10/23/08 Invited Speaker, Univ. of San Diego Research Medical Rounds, “Role of Cytokines/Chemokines during the pathogenesis of BOS”.

10/23/08 Invited Speaker, Univ. of San Diego Clinical Medical Rounds, “Lung Transplantation and BOS”.

11/21/08 Lecturer, Clinical Conference, Medicaly Division UCLA Medical Center, “Pre-Operative Pulmonary Evaluation for Surgery”

11/22/08 Lecturer, Clinical Conference, Medical Division UCLA Medical Center, “Ventilators”

11/23/08 Lecturer, Clinical Conference, Medical Division UCLA Medical Center, “Respiratory Failure”


11/08 20 hours of teaching to first year medical students on Pulmonary Physiology.

.

17

PUBLICATIONS/BIBLIOGRAPHY: RESEARCH PAPERS RESEARCH PAPERS (PEER REVIEWED)

A. RESEARCH PAPERS - PEER REVIEWED

1. Keane MP, Belperio JA, Moore TA, Moore BB, Arenberg DA, Smith RE, Burdick MD, Kunkel SL, Strieter RM. Neutralization of the CXC chemokine macrophage inflammatory protein-2 (MIP-2), attenuates bleomycin-induced pulmonary fibrosis. J. Immunol. 1999 ;162:5511-8.

2. Keane MP, Belperio JA, Arenberg DA, Burdick MD, Xu ZJ, Xue YY, Strieter RM. IFN-gamma-inducible protein-10 attenuates bleomycin-induced pulmonary fibrosis via inhibition of angiogenesis. J. Immunol. 1999;163:5686-92.

3. Belperio JA, Keane MP, Arenberg DA, Addison CL, Ehlert JE, Burdick MD, Strieter RM. CXC Chemokines in angiogenesis. J. Leukoc. Biol. 68:1-8, 2000.

4. Belperio JA, Burdick MD, Keane MP, Xue YY, Lynch JP, Daugherty BL, Kunkel SL, Strieter RM. The Role of the CC Chemokine, RANTES, in Acute Lung Allograft Rejection. J. Immunol. 165:461-472, 2000.

5. Keane MP, Belperio JB, Burdick MD, Strieter RM. IL-12 attenuates bleomycin-induced pulmonary fibrosis. Am J Physiol Lung Cell Mol Physiol 281:L92-L97, 2001.

6. Belperio JA, Keane MP, Burdick MD, Lynch JP, Xue YY, Berlin A, Ross DJ, Kunkel SL, Charo IF, Strieter RM. Critical role for the chemokine MCP-1/CCR2 in the pathogenesis of bronchiolitis obliterans syndrome. The Journal of Clinical Investigation 108: pending, 2001.

7. Belperio JA, Keane MP, Burdick MD, Lynch III, JP, Xue YY, Kunkel SL, Strieter RM. Elevated levels of MCP-1 are associated with bronchiolitis obliterans syndrome, a fibrotic disease of the small airways. Chest 2001 Jul; 120 (1 Suppl): S2, 2001.

8. Keane MP, Belperio JA, Burdick MD, Strieter RM. IL-12 attenuates pulmonary fibrosis via induction of IFN-γ. Chest 2001 Jul; 120 (1 Suppl): S8, 2001.

9. Keane MP, Belperio JA, Fishbein MF, Burdick MD, Lynch JP, Strieter RM. ENA-78 is an important angiogenic factor in idiopathic pulmonary fibrosis. Am J Respir Crit Care Med 164:2239-2242, 2001.

10. Belperio JA, DiGiovine B, Keane MP, Burdick MD, Xue YY, Lynch III JP, Kunkel SL, Strieter RM. Iinterleukin-1 receptor antagonist as a biomarker for bronchiolitis obliterans syndrome in lung transplant recipients. Transplantation 73:591-599, 2002.

11. Belperio JA, Keane MP, Burdick MD, Lynch JP 3rd, Xue YY, Li K, Ross DJ, Strieter RM. Critical role for CXCR3 chemokine biology in the pathogenesis of Bronchiolitis obliterans syndrome. J Immunol. 2002 Jul 15;169(2):1037-49.

18

12. Belperio JA, Dy M, Burdick MD, Xue YY, Li K, Elias JA, Keane MP. Interaction of IL-13 and C10 in the pathogenesis of bleomycin-induced pulmonary fibrosis. Am J Respir Cell Mol Biol. 2002 Oct;27(4):419-27.

13. Yun JJ, Fischbein MP, Whiting D, Irie Y, Fishbein MC, Burdick MD, Belperio J, Strieter RM, Laks H, Berliner JA, Ardehali A. The role of MIG/CXCL9 in cardiac allograft vasculopathy. Am J Pathol. 2002 Oct;161(4):1307-13.

14. Keane MP, Donnelly SC, Belperio JA, Goodman RB, Dy M, Burdick MD, Fishbein MC, Strieter RM. Imbalance in the Expression of CXC Chemokines Correlates with Bronchoalveolar Lavage Fluid Angiogenic Activity and Procollagen Levels in Acute Respiratory Distress Syndrome. J Immunol. 2002 Dec 1;169(11):6515-6521.

15. Belperio JA, Keane MP, Burdick MD, Londhe V, Xue YY, Li K, Phillips RJ, Strieter RM. Critical role for CXCR2 and CXCR2 ligands during the pathogenesis of ventilator-induced lung injury. J. Clin. Invest. 2002;110 1703-1716.

16. Phillips RJ, Burdick MD, Lutz M, Belperio JA, Keane MP, Strieter RM. The SDF-1/CXCL12/CXCR4 Biological Axis in Non-Small Cell Lung Cancer Metastases. Am J Respir Crit Care Med. 2003 Mar 5.

17. Kao J, Kobashigawa J, Fishbein MC, MacLellan WR, Burdick MD, Belperio JA, Strieter RM. Elevated serum levels of the CXCR3 chemokine ITAC are associated with the development of transplant coronary artery disease. Circulation. 2003 Apr 22;107(15):1958-61.

18. Kaminski N, Belperio JA, Bitterman PB, Chen L, Chensue SW, Choi AM, Dacic S, Dauber JH, Du Bois RM, Enghild JJ, Fattman CL, Grutters JC, Haegens A, Hanford LE, Heintz N, Henson PM, Hogaboam C, Kagan VE, Keane MP, Kunkel SL, Land S, Loyd JE, Lukacs N, MacPherson M, Manning B, Manning N, Martinelli M, Moller DR, Morse D, Mossman B, Noble PW, Nowak N, Oury TD, Pardo A, Perez A, Petty TL, Phan SH, Ramos-Nino ME, Ray P, Rogers RM, Sato H, Scapoli L, Schaefer LM, Selman M, Stern M, Strollo DC, Tyurin VA, Valnickova Z, Welsh KI, Witzmann FA, Yousem SA, Strieter RM. Idiopathic pulmonary fibrosis. Am J Respir Cell Mol Biol. 2003 Sep;29(3 Suppl 2):S1-S105.

19. Belperio JA, Keane MP, Burdick MD, Lynch JP 3rd, Zisman DA, Xue YY, Li K, Ardehali A, Ross DJ, Strieter RM. Role of CXCL9/CXCR3 chemokine biology during pathogenesis of acute lung allograft rejection.. J Immunol. 2003 Nov 1;171(9):4844-52.

20. Keane MP, Belperio JA, Xue YY, Burdick MD, Strieter RM. Depletion of CXCR2 inhibits tumor growth and angiogenesis in a murine model of lung cancer. J Immunol. 2004 Mar 1;172(5):2853-60.

21. Sue RD, Belperio JA, Burdick MD, Murray LA, Xue YY, Dy MC, Kwon JJ, Keane MP, Strieter RM. CXCR2 is critical to hyperoxia-induced lung injury. J Immunol. 2004 Mar 15;172(6):3860-8.

22. Strieter RM, Belperio JA, Phillips RJ, Keane MP. Chemokines: angiogenesis and metastases in lung cancer. Novartis Found Symp. 2004;256:173-84; discussion 184-8, 259-69.

19

23. Keane MP, Burdick MD, Xue YY, Lutz M, Belperio JA, Strieter RM. The chemokine receptor, CXCR2, mediates the tumorigenic effects of ELR+ CXC chemokines. Chest. 2004 May;125(5 Suppl):133S.

24. Belperio JA, Phillips RJ, Burdick MD, Lutz M, Keane M, Strieter R. The SDF-1/CXCL 12/CXCR4 biological axis in non-small cell lung cancer metastases. Chest. 2004 May;125(5 Suppl):156S.

25. Whiting D, Hsieh G, Yun JJ, Banerji A, Yao W, Fishbein MC, Belperio J, Strieter RM, Bonavida B, Ardehali A. Chemokine monokine induced by IFN-gamma/CXC chemokine ligand 9 stimulates T lymphocyte proliferation and effector cytokine production. J Immunol. 2004 Jun 15;172(12):7417-24

26. Addison CL, Belperio JA, Burdick MD, Strieter RM. Overexpression of the duffy antigen receptor for chemokines (DARC) by NSCLC tumor cells results in increased tumor necrosis. BMC Cancer. 2004 Jun 23;4(1):28

27. Strieter RM, Belperio JA, Phillips RJ, Keane MP. CXC chemokines in angiogenesis of cancer. Semin Cancer Biol. 2004 Jun;14(3):195-200

28. Phillips RJ, Burdick MD, Hong K, Lutz MA, Murray LA, Xue YY, Belperio JA, Keane MP, Strieter RM. Circulating fibrocytes traffic to the lungs in response to CXCL12 and mediate fibrosis, J Clin Invest. 2004 Aug;114(3):438-46.

29. Burdick MD, Murray LA, Keane MP, Xue YY, Zisman DA, Belperio JA, Strieter RM. CXCL11 Attenuates Bleomycin-Induced Pulmonary Fibrosis Via Inhibition of Vascular Remodeling. Am J Respir Crit Care Med. 2004 Oct 22.

30. Belperio JA, Dy M, Murray L, Burdick MD, Xue YY, Strieter RM, Keane MP. The role of the Th2 CC chemokine ligand CCL17 in pulmonary fibrosis. J Immunol. 2004 Oct 1;173(7):4692-8.

31. Ross DJ, Cole AM, Yoshioka D, Park AK, Belperio JA, Laks H, Strieter RM, Lynch JP 3rd, Kubak B, Ardehali A, Ganz T. Increased bronchoalveolar lavage human beta-defensin type 2 in bronchiolitis obliterans syndrome after lung transplantation. Transplantation. 2004 Oct 27;78(8):1222-4.

32. Phillips RJ, Mestas J, Gharaee-Kermani M, Burdick MD, Sica A, Belperio JA, Keane MP, Strieter RM. EGF and hypoxia-induced expression of CXCR4 on non-small cell lung cancer cells is regulated by the PI3-kinase/PTEN/AKT/mTOR signaling pathway and activation of HIF-1alpha. J Biol Chem. 2005 Jun 10;280(23):22473-81. Epub 2005 Mar 31.

33. Belperio JA, Keane MP, Burdick MD, Gomperts B, Xue YY, Hong K, Mestas J, Ardehali A, Mehrad B, Saggar R, Lynch JP, Ross DJ, Strieter RM. Role of CXCR2/CXCR2 ligands in vascular remodeling during bronchiolitis obliterans syndrome. J Clin Invest. 2005 May;115(5):1133-6.

34. Londhe VA, Belperio JA, Keane MP, Burdick MD, Xue YY, Strieter RM. CXCR2 is critical for dsRNA-induced lung injury: relevance to viral lung infection. J Inflamm (Lond). 2005 May 28;2(1):4.

35. El-Sawy T, Belperio JA, Strieter RM, Remick DG, Fairchild RL. Inhibition of polymorphonuclear leukocyte-mediated graft damage synergizes with short-term costimulatory blockade to prevent cardiac

20

allograft rejection. Circulation. 2005 Jul 19;112(3):320-31. Epub 2005 Jul 5.

36. Londhe VA, Belperio JA, Keane MP, Burdick MD, Xue YY, Strieter RM. Pediatr Res. 2005 Nov;58(5):919-26. Epub 2005 Sep 23. CXCR2/CXCR2 ligand biological axis impairs alveologenesis during dsRNA-induced lung inflammation in mice.

37. Belperio JA, Keane MP, Burdick MD, Gomperts BN, Xue YY, Hong K, Mestas J, Zisman D, Ardehali A, Saggar R, Lynch JP 3rd, Ross DJ, Strieter RM. CXCR2/CXCR2 ligand biology during lung transplant ischemia-reperfusion injury. J Immunol. 2005 Nov 15;175(10):6931-9.

38. Pan J, Burdick MD, Belperio JA, Xue YY, Gerard C, Sharma S, Dubinett SM, Strieter RM. CXCR3/CXCR3 Ligand Biological Axis Impairs RENCA Tumor Growth by a Mechanism of Immunoangiostasis. J Immunol. 2006 Feb 1;176(3):1456-64.

39. Gomperts BN, Belperio JA, Rao PN, Randell SH, Fishbein MC, Burdick MD, Strieter RM. Circulating Progenitor Epithelial Cells Traffic via CXCR4/CXCL12 in Response to Airway Injury. J Immunol. 2006 Feb 1;176(3):1916-1927.

40. Terada T, Zhang K, Belperio J, Londhe V, Saxon A. A chimeric human-cat Fcgamma-Fel d1 fusion protein inhibits systemic, pulmonary, and cutaneous allergic reactivity to intratracheal challenge in mice sensitized to Fel d1, the major cat allergen. Clin Immunol. 2006 Feb 10

41. Zhai Y, Shen XD, Hancock WW, Gao F, Qiao B, Lassman C, Belperio JA, Strieter RM, Busuttil RW, Kupiec-Weglinski JW. CXCR3+CD4+ T cells mediate innate immune function in the pathophysiology of liver ischemia/reperfusion injury. J Immunol. 2006 May 15;176(10):6313-22.

42. Pan J, Mestas J, Burdick MD, Phillips RJ, Thomas GV, Reckamp K, Belperio JA, Strieter RM. Stromal Derived Factor-1 (SDF-1/CXCL12) and CXCR4 in renal cell carcinoma metastasis. Mol Cancer. 2006 Nov 3;5(1):56.

43. Lynch JP 3rd, Saggar R, Weigt SS, Ross DJ, Belperio JA. Overview of lung transplantation and criteria for selection of candidates. Semin Respir Crit Care Med. 2006 Oct;27(5):441-69.

44. Keane MP, Gomperts BN, Weigt S, Xue YY, Burdick MD, Nakamura H, Zisman DA, Ardehali A, Saggar R, Lynch JP 3rd, Hogaboam C, Kunkel SL, Lukacs NW, Ross DJ, Grusby MJ, Strieter RM, Belperio JA. IL-13 is pivotal in the fibro-obliterative process of bronchiolitis obliterans. syndrome. J Immunol. 2007 Jan 1;178(1):511-9.

45. Gomperts BN, Belperio JA, Fishbein MC, Keane MP, Burdick MD, Strieter RM. Keratinocyte growth factor improves repair in the injured tracheal epithelium. Gomperts BN, Belperio JA, Fishbein MC, Keane MP, Burdick MD, Strieter RM.

46. Hong KM, Belperio JA, Keane MP, Burdick MD, Strieter RM. Differentiation of human circulating fibrocytes as mediated by transforming growth factor-beta and peroxisome proliferator-activated receptor gamma. J Biol Chem. 2007 Aug 3;282(31):22910-20. Epub 2007 Jun 7.

21

47. Zisman DA, Karlamangla AS, Ross DJ, Keane MP, Belperio JA, Saggar R, Lynch JP 3rd, Ardehali A, Goldin J. High-resolution chest CT findings do not predict the presence of pulmonary hypertension in advanced idiopathic pulmonary fibrosis. Chest. 2007 Sep;132(3):773-9. Epub 2007 Jun 15.

48. Zisman DA, Ross DJ, Belperio JA, Saggar R, Lynch JP 3rd, Ardehali A, Karlamangla AS. Prediction of pulmonary hypertension in idiopathic pulmonary fibrosis. Respir Med. 2007 Oct;101(10):2153-9. Epub 2007 Jul 2.

49. Zisman DA, Karlamangla AS, Kawut SM, Shlobin OA, Saggar R, Ross DJ, Schwarz MI, Belperio JA, Ardehali A, Lynch JP 3rd, Nathan SD. Validation of a method to screen for pulmonary hypertension in advanced idiopathic pulmonary fibrosis. Chest. 2008 Mar;133(3):640-5. Epub 2008 Jan 15.

50. Schnickel GT, Bastani S, Hsieh GR, Shefizadeh A, Bhatia R, Fishbein MC, Belperio J, Ardehali A. Combined CXCR3/CCR5 blockade attenuates acute and chronic rejection. J Immunol. 2008 Apr 1;180(7):4714-21.

51. Gregson AL, Hoji A, Saggar R, Ross DJ, Kubak BM, Jamieson BD, Weigt SS, Lynch JP 3rd, Ardehali A, Belperio JA, Yang OO. Bronchoalveolar immunologic profile of acute human lung transplant allograft rejection. Transplantation. 2008 Apr 15;85(7):1056-9.

52. Weigt SS, Elashoff RM, Keane MP, Strieter RM, Gomperts BN, Xue YY, Ardehali A, Gregson AL, Kubak B, Fishbein MC, Saggar R, Ross DJ, Lynch Iii JP, Zisman DA, Belperio JA. Altered Levels of CC Chemokines During Pulmonary CMV Predict BOS and Mortality Post-Lung Transplantation. Am J Transplant. 2008 May 28. [Epub ahead of print]

53. Sarafian T, Montes C, Harui A, Beedanagari SR, Kiertscher S, Stripecke R, Hossepian D, Kitchen C, Kern R, Belperio J, Roth MD. Clarifying CB2 receptor-dependent and independent effects of THC on human lung epithelial cells. Toxicol Appl Pharmacol. 2008 May 9. [Epub ahead of print].

54. Nathan SD, Shlobin OA, Barnett SD, Saggar R, Belperio JA, Ross DJ, Ahmad S, Saggar R, Libre E, Lynch JP 3rd, Zisman DA. Right ventricular systolic pressure by echocardiography as a predictor of pulmonary hypertension in idiopathic pulmonary fibrosis. Respir Med. 2008 Jul 9. [Epub ahead of print].

55. Saggar R, Ross DJ, Saggar R, Zisman DA, Gregson A, Lynch Iii JP, Keane MP, Weigt SS, Ardehali A, Kubak B, Lai C, Elashoff D, Fishbein MC, Wallace WD, Belperio JA. Pulmonary Hypertension Associated with Lung Transplantation Obliterative Bronchiolitis and Vascular Remodeling of the Allograft. Am J Transplant. 2008 Jul 28. [Epub ahead of print].

56. Belperio JA, Ardehali A. Chemokines and transplant vasculopathy. Circ Res. 2008 Aug 29;103(5):454-66.

57. Zisman DA, Kawut SM, Lederer DJ, Belperio JA, Lynch JP, Schwarz MI, Tayek JA, Reuben DB, Karlamangla AS. Serum Albumin Concentration

22

and Waiting List Mortality in Idiopathic Interstitial Pneumonia. Chest. 2008 Nov 18. [Epub ahead of print]

B. RESEARCH PAPERS - PEER REVIEWED (IN PRESS)

C. RESEARCH PAPERS - PEER REVIEWED (SUBMITTED) 1) Role of Aspergilus and BOS

2)Role of ELR- CXC chemokines and Sarcoidosis

RESEARCH PAPERS (NON-PEER REVIEWED)

D. RESEARCH PAPERS – NON-PEER REVIEWED

1) Pathogenesis of BOS E. RESEARCH PAPERS – NON-PEER REVIEWED (IN PRESS)

NONE F. RESEARCH PAPERS – NON-PEER REVIEWED (SUBMITTED)

NONE CHAPTERS

1. Strieter RM, Belperio JA, Arenberg DA, Smith MI, Burdick MD, Keane MP.

CXC chemokines in angiogenesis. In Ransohoff, R. (Ed). Universes in delicate balance: Chemokines and the nervous system. Elsevier Science, Amsterdam, The Netherlands. In Press.

2. Strieter RM, Belperio JA, Kelley D, Sakkour A, Keane MP. The role of chemokines in the recruitment of leukocytes during lung inflammation. In Wong H and Shanley TP (Eds) Molecular Biology of Acute Lung Injury. Kluwer Academic Publishers, Norwell, MA. 2001.

3. Strieter RM, Belperio JA, Kelley D, Sakkour A, Keane MP. Innate immune mechanisms triggering lung injury. In Wong H and Shanley TP (Eds) Molecular Biology of Acute Lung Injury. Kluwer Academic Publishers, Norwell, MA. 2001.

23

4. Strieter RM, Burdick MD, Beleprio JA, Keane MP. Methods to measure chemokines at the protein level in tissue. In Wound Healing: methods and protocols. Editors DiPietro LA and Burns-Harring AL. The Humana Press, Inc., Totowa, NJ. In Press.

5. Keane MP, Belperio JA, Strieter RM. Chemokines in Pulmonary Fibrosis. In Strieter RM, Kunkel SL, Standiford TJ, Lenfant C, (Eds) Chemokines in the Lung. Marcel Decker, New York, NY. In Press.

6. Strieter RM, Belperio JA, Dubinett SM, Keane MP. Chemokines in Lung Cancer. In Strieter RM, Kunkel SL, Standiford TJ, Lenfant C, (Eds) Chemokines in the Lung. Marcel Decker, New York, NY. In Press.

7. Belperio JA, Keane MP, Strieter RM. Chemokines in Lung Transplantation. In Strieter RM, Kunkel SL, Standiford TJ, Lenfant C, (Eds) Chemokines in the Lung. Marcel Decker, New York, NY. In Press.

8. Keane MP, Belperio JA, Strieter RM. Cytokine biology and the pathogenesis of interstitial lung disease. In Schwarz MI & TE King (eds.) Interstitial Lung Disease. 2nd Edition, B.C. Decker, Inc., Hamilton, Ontario, Canada, (In press)

9. Robert M. Strieter, Marie D. Burdick, John A. Belperio, Michael P. Keane METHODS TO MEASURE CHEMOKINES AT THE PROTEIN LEVEL IN TISSUE (Submitted to : Wound healing: methods and protocols. Editors DiPietro LA and Burns-Harring AL. The Humana Press, Inc., Totowa, NJ)

10. Strieter RM, Belperio JB, Keane MP. CXC chemokines in angiogenesis related to pulmonary fibrosis. In Lynch JP (Ed) Idiopathic Pulmonary Fibrosis. Marcel Decker, New York, NY. In Press.

LETTERS TO THE EDITOR

NONE

REVIEWS

1. Lynch JP, Belperio JA Flint A, Martinez FJ. Bronchiolitis Obliterans and Connective tissue Disease. Sem. Respir. Crit. Care Med. 1999; 20:149-68.

2. Strieter RM, Addison CL, Ehlert JE, Keane MP, Belperio JA, Burdick MD, Arenberg DA. Use of Immunodeficient Mice for the Evaluation of CXC Chemokines in the Regulation of Tumor-associated Angiogenesis ILAR Journal 1999; 40:175-82.

3. Strieter RM, Belperio JA, Keane MP. Cytokines in innate host defense in the lung. J Clin Invest 109:699-705, 2002.

4. Strieter RM, Belperio JA, Keane MP. CXC chemokines in angiogenesis related to pulmonary fibrosis. Chest. 2002 Dec;122(6 Suppl):298S-301S

5. Belperio JA, Keane MP, Strieter RM. The Role for Chemokines/Chemokine Receptors in the Pathogenesis of Lung Allograft Rejection. Vol 8 No 1 March 2003 Current Opinion in Organ Transplantation, 8:40-48

6. Belperio JA, Keane MP, Strieter RM. Cytokines during the Pathogenesis of Lung Allograft Rejection. Current Opinion in Organ Transplantation, 8:228-238

7. Strieter RM, Burdick MD, Belperio JA, Keane MP. Measurement of chemokines at the protein level in tissue, Methods Mol Med. 2003;78:377-88

8. Strieter RM, Belperio JA, Keane MP. Host innate defenses in the lung: the role of cytokines, Curr Opin Infect Dis. 2003 Jun;16(3):193-8

24

9. Strieter RM, Belperio JA, Keane MP. CXC chemokines in vascular remodeling related to pulmonary fibrosis. Am J Respir Cell Mol Biol. 2003 Sep;29(3 Suppl):S67-9.

10. Belperio JA, Keane MP, Lynch JP, Strieter RM. Obliterative Bronchiolitis complicating heart lung or lung transplantation. Seminars in Respiratory and Critical Care Medicine. Vol 24 No 5 2003 pp 499

11. Belperio JA and Strieter RM. Chemokines/Chemokine Receptors play an important role in the continuum of acute to chronic lung allograft rejection. Vol 9 No 3 Sept 2004pp350.

12. Strieter RM, Belperio JA, Burdick MD, Sharma S, Dubinett SM, Keane MP. CXC chemokines: angiogenesis, immunoangiostasis, and metastases in lung cancer. Ann N Y Acad Sci. 2004 Dec;1028:351-60.

13. Strieter RM, Belperio JA, Burdick MD, Keane MP. CXC chemokines in angiogenesis relevant to chronic fibroproliferation. Curr Drug Targets Inflamm Allergy. 2005 Feb;4(1):23-6.

14. Strieter RM, Burdick MD, Gomperts BN, Belperio JA, Keane MP. Cytokine Growth Factor Rev. 2005 Dec;16(6):593-609. Epub 2005 Jul 19. CXC chemokines in angiogenesis.

15. Strieter RM, Keane MP, Burdick MD, Sakkour A, Murray LA, Belperio JA. Curr Drug Targets Inflamm Allergy. 2005 Jun;4(3):299-303. The role of CXCR2/CXCR2 ligands in acute lung injury.

16. Zisman DA, Keane MP, Belperio JA, Strieter RM, Lynch JP 3rd. Methods Mol Med. 2005;117:3-44. Pulmonary fibrosis.

17. Keane MP, Strieter RM, Belperio JA. Mechanisms and mediators of pulmonary fibrosis. Crit Rev Immunol. 2005;25(6):429-63.

18. Strieter RM, Burdick MD, Mestas J, Gomperts B, Keane MP, Belperio JA. Cancer CXC chemokine networks and tumour angiogenesis. Eur J Cancer. 2006 Apr;42(6):768-778.

19. Belperio JA, Keane MP, Lynch JP 3rd, Strieter RM. The Role of Cytokines during the Pathogenesis of Ventilator-Associated and Ventilator-Induced Lung Injury. Semin Respir Crit Care Med. 2006 Aug;27(4):350-64.

20. Belperio JA, Keane MP, Lynch JP 3rd, Strieter RM. The role of cytokines during the pathogenesis of ventilator-associated and ventilator-induced lung injury. Semin Respir Crit Care Med. 2006 Aug;27(4):350-64.

21. Lynch JP 3rd, Saggar R, Weigt SS, Ross DJ, Belperio JA. Overview of lung transplantation and criteria for selection of candidates. Semin Respir Crit Care Med. 2006 Oct;27(5):441-69.

22.

EDITORIALS

1. Strieter RM, Belperio JA Chemokine Receptor Polymorphism in Transplantation Immunology: No Longer Just Important in AIDS. The Lancet 357:1726, 2001.

2. Belperio JA. Paying a toll for acute lung allograft rejection. Am J Respir Crit Care Med. 2003 Sep 15;168(6):623-4.

PAPERS IN PREPARATION (RESEARCH COMPLETED)

NONE

25

ABSTRACTS

1. Belperio JA, Chen B, Xue YY, Burdick MD, Kunkel SL, Strieter RM. RANTES is an important CC chemokine that mediates acute lung allograft rejection. Keystone Symposia on Molecular & Cellular Biology-Chemokines and Chemokine Receptors. Keystone, CO, January 21, 1999.

2. Keane MP, Moore TA, Moore BB, Arenberg DA, Belperio JA, Wilke CA, Burdick MD, Taub DD, Strieter RM. Production and function of C10 during bleomycin-induced pulmonary fibrosis. Keystone Symposia on Molecular & Cellular Biology-Chemokines and Chemokine Receptors. Keystone, CO, January 20, 1999.

3. Belperio JA, Chen B, Xue YY, Burdick MD, Morris S, Keane MP, Kunkel SL, Strieter RM. Lung transplantation allograft rejection is attenuated by in vivo neutralization of RANTES. Am J. Respir. Crit. Care Med. 159:A276, 1999.

4. Xu ZJ, Keane MP, Belperio JB, Burdick MD, Xue YY, Strieter RM. Production and function of MIP-1α during acute lung injury. Am J. Respir. Crit. Care Med. 159:A592, 1999.

5. Keane MP, Moore TA, Moore BB, Arenberg DA, Belperio JA, Wilke CA, Burdick MD, Taub DD, Strieter RM. C10 is an important chemokine during the pathogenesis of bleomycin-induced pulmonary fibrosis. Am J. Respir. Crit. Care Med. 159:A73, 1999.

6. Belperio JB, Chen B, Xue YY, Burdick MD, Morris S, Keane MP, Kunkel SL, Strieter RM. Elevated levels of MCP-1 are associated with Acute Rat Lung Transplantation Allograft Rejection. FASEB J. 13:A1130, 1999.

7. Keane MP, Belperio JA, Xu ZJ, Xue YY, Burdick MD, Arenberg DA, Strieter RM. IL-12 attenuates bleomycin-induced pulmonary fibrosis. FASEB J. 13:A818, 1999.

8. Paciocco G, Ojo TC, Lynch III JP, Belperio J, Iannettoni M, Florn R, Martinez FJ. Cytomegalovirus (CMV) prophylaxis in lung transplant recipients: randomized trial of varying ganciclovir (GAN) regimens. Eur Respir J 1999; 14 (Suppl 30): 320S.

9. Belperio JA, Chen B, Xue YY, Burdick MD, Morris S, Keane MP, Kunkel SL, Strieter RM. Elevated levels of MCP-1 are associated with acute rat lung transplantation allograft rejection. FASEB J. 13:A1130, 1999.

10. Belperio JA, Keane MP, Burdick MD, DiGiovine B, Lynch JP, Xue YY, Kunkel SL, Strieter RM. Bronchoalveolar Lavage (BAL) Levels of Interleukin-1 Receptor Antagonist (IL-1Ra) is Associated with Obliterative Bronchiolitis (OB) After Lung Transplantation FASEB J, 14:A188, 2000.

11. Belperio JA, Keane MP, Burdick MD, Xue YY, Berlin AA, Charo IR, Kunkel SL, Strieter RM. Elevated Levels of MCP-1 are Associated with Chronic Allograft Rejection. Am J. Respir. Crit. Care Med. 161:A508, 2000.

12. Keane MP, Belperio JA, Arenberg DA, Burdick MD, Strieter RM. IL-12 Attenuates Bleomycin-induced Pulmonary Fibrosis by Inducing Expression of IFN-γ. Am J. Respir. Crit. Care Med. 161:A751, 2000.

26

13. Keane MP, Belperio JA, Burdick MD, Strieter RM. IL-12 Attenuates Pulmonary Fibrosis Via Induction of IFN-γ. Presented at the Thomas L. Petty Aspen Lung Conference 43rd Annual Meeting, Aspen, CO, May 31, 2000.

14. Belperio JA, Keane MP, Burdick MD, Lynch III, JP, Xue YY, Kunkel SL, Strieter RM. Elevated levels of MCP-1 are associated with bronchiolitis obliterans syndrome, a fibrotic disease of the small airways. Presented at the Thomas L. Petty Aspen Lung Conference 43rd Annual Meeting, Aspen, CO, May 31, 2000.

15. JA Belperio, MP Keane, MD Burdick, JP Lynch III, YY Xue, KW Li, RM Strieter. The Role of RANTES and MIP-1a during the pathogenesis of Bronchiolitis Obliterans Syndrome. Submitted to Keystone Chemokine Conference 2001.

16. Keane MP, Belperio JA, Burdick MD, Strieter RM. IL-12 attenuates pulmonary fibrosis via induction of IFN-γ. 23rd Southern California Pulmonary and Critical Care Medicine Research Conference, Palm Springs, Feb 9-11, 2001.

17. JA Belperio, MP Keane, MD Burdick, JP Lynch III, YY Xue, KW Li, RM Strieter. Elevated Levels of RANTES, not MIP-1α are Associated with Bronchiolitis Obliterans Syndrome. Submitted to California Pulmonary Palm Springs Conference 2001.

18. Keane MP, Belperio JA, Burdick MD, Xue YY, Li K, Elias JA, Strieter RM. IL-13 regulates pulmonary fibrosis via induction of C10. Keystone Symposium: Chemokines and Chemokine receptors Feb 16-21, 2001.

19. JA Belperio, MP Keane, MD Burdick, YY Xue, KW Li, RM Strieter. Protective (Low Stretch) Mechanical Ventilation is Associated with Lower Levels of MIP-2 and KC as compared to Injurious (High Stretch) Mechanical Ventilation in a Murine Model of Ventilator Induced Lung Injury. Submitted to FASEB Conference 2001.

20. DJ Ross, AM Cole, D Yoshioka, AK Park, RS Strieter, J Belperio, B Kubak, H Laks, A Ardehali, T Ganz. Increased BAL Human Beta-Defensin-2 in Bronchiolitis Obliterans Syndrome after Lung Transplantation. Submitted to ISHLT 2002.

21. DJ Ross, RS Strieter, J Belperio, S Lackey, MS Levine, B Kubak, RS Shpiner, H Laks, A Ardehali. Expanded Donor Criteria Significantly Decrease Waiting Times for Lung Transplantation in UNOS Region 5. Submitted to ISHLT 2002

22. Strieter RM, Belperio JA, Keane MP. Chemokine regulation of angiogenesis in chronic fibroproliferative disorders. Lovelace Respiratory Research Institute International Symposium: Remodeling and repair in respiratory diseases, Santa Fe, NM, October 14-17, 2001.

23. Strieter RM, Keane MP, Belperio JA, Dubinett S, Burdick MD. The Imbalance in the Expression of Angiogenic ELR+, as Compared to Angiostatic IFN-Inducible ELR- CXC Chemokines, is Correlated to NSCLC-Derived Angiogenesis and Recurrence of Surgical Stage I Adenocarcinoma. 9th SPORE investigators workshop, National Cancer Institute, July 15-17, 2001.

24. Keane MP, Belperio JA, Burdick MD, Xue YY, Li K, Elias JA, Strieter RM. IL-13 is an important cytokine in the pathogenesis of pulmonary fibrosis. Am J. Resp Crit Care Med 163: A43, 2001

27

25. Keane MP, Donnelly SC, Belperio JA, Goodman R, Burdick MD, Strieter RM. IL-8 correlates with BALF angiogenic activity and pro-collagen levels in ARDS. Submitted to ATS 2002.

26. Belperio JA, Keane MP, Burdick MD, Lynch JP, Xue YY, Li KW, Strieter RM. Critical Role for MIG/CXCR3 Chemokine Biology in the Pathogenesis of Acute lung Allograft Rejection. FASEB 2002

27. Belperio JA, Keane MP, Burdick MD, Lynch JP, Xue YY, Li KW, Strieter RM. Critical Role for CXCR3 Chemokine Biology in the Pathogenesis of Bronchiolitis Obliterans Syndrome. ATS 2002

28. J Kao MD, MC Fishbein MD, JA Kobashigawa MD*, JK Patel MD PhD, RC McLellan MD, M Burdick, J Belperio MD, RM Streiter MD. Elevated Levels of the CXCR3 Chemokine Ligand ITAC is Associated with the development of Severe Transplant Coronary Artertery Disease in Humans for ISHLT 23rd Annual Meeting and Scientific Sessions from April 9-12, 2003 in Vienna, Austria.

29. JA Belperio, M Dy, MD Burdick, YY Xue, K Li, RM Strieter, MP Keane The Role of the TH2 Chemokines, MDC AND TARC, in Pulmonary Fibrosis. ATS 2003 in Seattle Washington

30. JA Belperio, M Dy, MD Burdick, YY Xue, K Li, RM Strieter, MP Keane The Role of the TH2 Chemokines, MDC AND TARC, in Pulmonary Fibrosis. AFMR 2003Carmel, California

31. VA Londhe, JA Belperio, MP Keane, MD Burdick, YY Xue, and RM Strieter Chemokine Biology in Virus Induced Lung Inflammation…A PRELUDE TO BRONCHOPULMONARY DYSPLASIA? VA Londhe, JA Belperio, MP Keane, MD Burdick, YY Xue, and RM Strieter (Soc. of Peds Research; W=Western), ATS, 2003

32. RD Sue, MP Keane, JA Belperio, MD Burdick, MC Dy, YY Xue, RM Strieter. Elevated Levels of KC/CXCL1 AND MIP-2/CXCL2/3 are associated with Hyperoxia Induced Lung Injury. FASEB 2003, San Diego, California

33. VA Londhe, JA Belperio, MP Keane, MD Burdick, YY Xue, and RM Strieter Chemokine Biology in Virus Induced Lung Inflammation…A PRELUDE TO BRONCHOPULMONARY DYSPLASIA? VA Londhe, JA Belperio, MP Keane, MD Burdick, YY Xue, and RM Strieter (Soc. of Peds Research), 2003

34. JA Belperio, MP Keane, MD Burdick, CL Addison**, JP Lynch III*, V Londhe, YY Xue, A Ardehali, Ross DJ, RM Strieter. Critical role for IL-10 Cytokine Biology in the Pathogenesis of Acute Lung Allograft Rejection. ATS Seattle Washington, 2003

35. VA Londhe, JA Belperio, MP Keane, MD Burdick, YY Xue, and RM Strieter Chemokine Biology in Virus Induced Lung Inflammation…A PRELUDE TO BRONCHOPULMONARY DYSPLASIA? VA Londhe, JA Belperio, MP Keane, MD Burdick, YY Xue, and RM Strieter (Soc. of Peds Research; W=Western), Carmel 2003

36. JA Belperio, MP Keane, MD Burdick, YY Xue, KW Li, A Ardehali DJ Ross, RM Strieter. The Role for KC/CXCL1 AND MIP-2/CXCL2/3 in the Pathogenesis of Lung Transplantation Ischemia Reperfusion Injury. FASEB, San Diego, 2003

37. THE CHEMOKINE RECEPTOR, CXCR2, MEDIATES THE TUMORIGENIC EFFECTS OF ELR+ CXC CHEMOKINES. Marie D. Burdick*, Ying Ying Xue*, Marin Lutz*, John A. Belperio*, Michael P. Keane*, Robert M. Strieter*+.

28

Lung Cancer SPORE at the David Geffen School of Medicine at UCLA, Departments of *Medicine and +Pathology, Division of Pulmonary and Critical Care Medicine, Los Angeles, CA 90024.

38. MULTI-FREQUENCY FORCED OSCILLATION TECHNIQUE [FOT] FOR ASSESSMENT OF LUNG ALLOGRAFT FUNCTION: A PILOT STUDY. D J Ross, M.D. 1*, M D Goldman, Ph.D. 2, R M Strieter, M.D. 1, J A Belperio, M.D. 1 and A Ardehali, M.D. 3. 1 Medicine, UCLA, Los Angeles, CA ; 2 Medicine, King Drew/UCLA, Los Angeles, CA and 3 Surgery, UCLA, Los Angeles, CA . The International Society for Heart and Lung Transplantation 24th Annual Meeting and Scientific Sessions

john a. belperio, m.d. personal history belperio class cv 12 05.pdf · undergraduate training: 1983...

Documents