Sept – Oct 2019ReseaRch Bulletin

JOHN DA SILVA, DMD, MPH, ScM, RECEIVES DENTAQUEST AWARDDr. John D. Da silva, vice dean of hsDM, medical director of the harvard Dental center, and associate professor of Restorative Dentistry and Biomaterials sciences, received an award from DentaQuest for, “testing a new Payment Model for Medical-Dental integration.”

The intent of this project is to demonstrate the financial sustainability of an innovative, person-centered care model, the Nurse Practitioner-Dentist Model for Primary Care (NPD Model), at the Harvard Dental Center’s Teaching Practices. The goal is a replicable,

scalable, and sustainable payment model to support the integration of primary medical care and preventive services within a dental practice. The team will develop and test processes and systems for medical coding, billing, claims submission and reimbursement. This project is aligned with an Oral Health 2020 goal of integrating oral health into person-centered healthcare. It is expected that results will advance medical-dental integration, precipitate innovative, person-centered care models, and positively influence the public perception of the value of the dental office as a gateway to comprehensive health care.

Jane Barrow, MS, associate dean for Global and Community Health and lecturer in the department of Oral Health Policy and Epidemiology at HSDM, will serve as strategic advisor; Leonard Brennan, DMD, lecturer in the department of Oral Health Policy and Epidemiology at HSDM, will serve as coordinator for the NPD Model; and, Maria c. Dolce, PhD, Rn, cne, associate professor will serve as the co-principal investigator. The National Advisory Group includes: Dr. Sung Eun Choi, instructor in the Department of Oral Health Policy and Epidemiology at HSDM; Dr. Richard Duferrena, Chief Dental Officer, United Concordia Companies; Dr. Judith haber, professor, New York University Rory Meyers College of Nursing; Dr. Robert lewando, Executive Dental Director, Blue Cross Blue Shield of Massachusetts; Mr. edward a. Murphy, Executive Vice President, Life & Specialty Ventures, LLC; Dr. M. ted Wong, Chief Dental Officer, UnitedHealthcare; and, Dr. Kenneth R. Wright, Vice President, Dental Care Services, Kaiser Foundation Health Plan of the Northwest.

HONORING DEAN BRUCE DONOFF

SAVE THE DATE – DECEMBER 10, 2019

ORAL AND CRANIOFACIALREGENERATIVE BIOLOGYAND MEDICINE SYMPOSIUM

• 1-4PM SYMPOSIUM • 4-6PM RECEPTION • HSDM

PRESENTATIONS BY: BRUCE PASTER, MARIA TROULIS, RICHARD MAAS, DAVID MOONEY AND BJORN R. OLSEN

A publication of the Office of Research 188 longwood avenue – Boston, Ma 02115

Malcolm Whitman, PhD Associate Dean for Basic Science

Yingzi Yang, PhD Associate Dean for Translational Research

Dawn M. Decosta Editor and Layout

heather M. Denny Editing

lia sgourakes Editing

ashley simmonsEditing and Photography

2 Research Bulletin • September – October 2019 • Harvard School of Dental Medicine

PUBLICATIONSDEVELOPMENTAL BIOLOgyDeng Q, Li P, Che M, Liu J, Biswas S, Ma G, He L, Wei Z, Zhang Z, Yang Y, Liu H, Li B. Activation of Hedgehog signaling in mesenchymal stem cells induces cartilage and bone tumor formation via Wnt/β-catenin. Elife 2019; Sep 4;8.

O’Keefe R, Tuan R, Lane N, Barry F, Bunnell B, Colnot C, Drake M, Drissi H, Fortier L, Guldberg R, Little D, Marshall M, Mao J, Nakamura N, Robey P, Rosen V, Rowe D, Schwarz E. American Society for Bone and Mineral Research – Orthopaedic Research Society joint task force report on cell-based therapies. Bone and Mineral Research 2019; Sep 23.

Zhu S, Kuek V, Bennett S, Xu H, Rosen V, Xu J. Protein Cytl1: its role in chondrogenesis, cartilage homeostasis, and disease. Cellular and Molecular Life Sciences 2019;76(18):3515-3523.

ORAL MEDICINE, INfECTION AND IMMUNITy Deng S, Hu Y, Zhou J, Wang Y, Wang Y, Li S, Huang G, Peng C, Hu A, Yu Q, Han X. TLR4 mediates alveolar bone resorption in experimental peri-implantitis through regulation of CD45+cell infiltration, RANKL/OPG ratio, and inflammatory cytokine production. Periodontology 2019; Sep 6.

Ducommun J, El Kholy K, Rahman L, Schimmel M, Chappuis V, Buser D. Analysis of trends in implant therapy at a surgical specialty clinic: Patient pool, indications, surgical procedures, and rate of early failures-A 15-year retrospective analysis. Clinical Oral Implants Research 2019; Aug 10.

El Kholy K, Lazarin R, Janner S, Faerber K, Buser R, Buser D. Influence of surgical guide support and implant site location on accuracy of static computer-assisted implant surgery. Clinical Oral Implants Research 2019; Aug 19.

Fantozzi P, Treister N, Shekar R, Woo SB, Villa A. Intralesional triamcinolone acetonide therapy for inflammatory oral ulcers. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology 2019; Aug 13.

Green D, Schulte F, Lee K, Pugach M, Hardt M, Bidlack F. Mapping the tooth enamel proteome and amelogenin phosphorylation onto mineralizing porcine tooth crowns. Frontiers in Physiology 2019; Jul 30;10:925.

Gupta A, Feldman S, Perkins R, Stokes A, Sankar V, Villa A. Predictors of dental care use, unmet dental care need, and barriers to unmet need among women: results from NHANES, 2011-16. Public Health Dentistry 2019; Aug 13.

Gupta A, Sonis S, Uppaluri R, Bergmark R, Villa A. Disparities in oral cancer screening among dental professionals: NHANES 2011-2016. American Journal of Preventive Medicine 2019; Aug 13.

He P, Mah-Ginn K, Karhade D, Donoff B, Adeeb N, Gupta R, Medford S, Afshar S. How often do oral maxillofacial surgeons lose malpractice cases and why? Oral and Maxillofacial Surgery 2019; Jul 10.

Kong X, Liu J, Cetinbas M, Sadreyev R, Koh M, Huang H, Adeseye A, He P, Zhu J, Russell H, Hobbie C, Liu K, Onderdonk A. New and preliminary evidence on altered oral and gut microbiota in individuals with Autism Spectrum Disorder (ASD): Implications for ASD diagnosis and subtyping based on microbial biomarkers. Nutrients 2019;11(9).

Rossetti B, Wilbert S, Mark Welch J, Borisy G, Nagy J. Semi-blind sparse affine spectral unmixing of autofluorescence-contaminated micrographs. Bioinformatics 2019; Aug 29.

NEW RESEARCHERS Shuang (Arthur) Liang, MD, joined the Baron-Gori Lab for two years as a visiting graduate student in the department of Oral Medicine, Infection and Immunity. Liang received his MD from Tongji Medical College of Huazhong University of Science and Technology where he is a PhD candidate in orthopedic surgery. At HSDM, Liang will

work on the skeletal effects and mechanisms of action of R-spondin-3 conditional deletion in osteoblasts. This work will elucidate, through cell specific deletion, the biological significance of R-spondin-3 in postnatal bone homeostasis.

Jun Zhou, DDS, PhD, joined the Baron-Gori Lab for two years as a visiting graduate student in the department of Oral Medicine, Infection and Immunity. Zhou has a DDS degree from Tianjin Medical University, Tianjin, China, and completed a PhD in Dentistry in March 2019 from Showa University, Japan. Zhou has a position as postdoctoral

fellow at Showa University and is coming to HSDM to further develop her research skills in the area of cell and molecular biology.

Alann Thaffarell Portilho de Souza, DDS, joined the Baron-Gori Lab for one year as a visiting graduate student in the department of Oral Medicine, Infection and Immunity. Portilho de Souza received a DDS degree from the Federal University of Para, School of Dentistry in Brazil. He is currently a PhD candidate in oral and

maxillofacial surgery at the University of Sao Paolo, Brazil. At HSDM, he will work on elucidating the role of mono-allelic mutations found in a small human cohort of patients who suffered atypical femoral fractures.

continued on page 4

Research Bulletin • September – October 2019 • Harvard School of Dental Medicine 3

Jazayeri H, Xu T, Khavanin N, Dorafshar A, Peacock Z. Evaluating the July effect in oral and maxillofacial surgery: Mandibular fractures. Oral and Maxillofacial Surgery 2019; Aug 9.

Jazayeri H, Xu T, Khavanin N, Dorafshar A, Peacock Z. Evaluating the July effect in oral and maxillofacial surgery: Orthognathic surgery. Oral and Maxillofacial Surgery 2019; Sept 4.

Kaban L, Perrott D. Dual-degree oral and maxillofacial surgery training in the United States: “Back to the Future.” Oral and Maxillofacial Surgery 2019; Sept 10.

Knoops P, Papaioannou A, Borghi A, Breakey R, Wilson A, Jeelani O, Zafeiriou S, Steinbacher D, Padwa B, Dunaway D, Schievano S. A machine learning framework for automated diagnosis and computer-assisted planning in plastic and reconstructive surgery. Science Reports 2019;9(1):13597.

Patel N, Keith D. Five-year comparative analysis of Medicare opioid prescription volume among oral and maxillofacial surgeons. Oral and Maxillofacial Surgery 2019; Jul 16.

Peacock Z. Adjunctive strategies for benign maxillofacial pathology. Oral and Maxillofacial Surgery Clinics of North America 2019; Aug 16.

Resnick C, Calabrese C. Is obstructive apnea more severe in syndromic than nonsyndromic patients with Robin Sequence? Oral and Maxillofacial Surgery 2019; Aug 9.

ORAL HEALTH POLICy AND EPIDEMIOLOgyAlqaderi H, Tavares M, Riedy C. Residents’ perspectives on and application of dental public health competencies using case-based methods. Dental Education 2019; Sep 9.

Chandrupatla S, Khalid I, Tavares M. Oral HPV prevalence and HPV vaccination among special needs population in the US. Papillomavirus Research 2019; Aug 29.

Eisenstein L, Fisher J, Simon L, Tobey M. Challenges and opportunities for patients released from correctional facilities. General Internal Medicine 2019; Aug 6.

Goodell K, Ticku S, Fazio S, Riedy C. Entrustable professional activities in oral health for primary care providers based on a scoping review. Dental Education 2019; Sep 9.

Nzabonimana E, Isyagi M, Njunwa K, Hackley D, Razzaque M. Use of an online medical database for clinical decision-making processes: Assessment of knowledge, attitude, and practice of oral health care providers. Advances in Medical Education Practice 2019;10:461-467.

Simon L, Candamo F, He P, Karhade D, Pirooz Y, Spinella M, Truong M, Wu X, Donoff R. Gender differences in academic productivity and advancement among dental school faculty. Womens Health 2019; Aug 2.

MULTI-DEPARTMENTALEl Kholy K, Ebenezer S, Wittneben J, Lazarin R, Rousson D, Buser D. Influence of implant macrodesign and insertion connection technology on the accuracy of static computer-assisted implant surgery. Clinical Implant Dental Related Research 2019; Aug 19.

Green D, Schulte F, Lee K, Pugach M, Hardt M, Bidlack F. Mapping the tooth enamel proteome and amelogenin phosphorylation onto mineralizing porcine tooth crowns. Frontiers in Physiology 2019;10:925.

Jazayeri H, Ganjawalla K, Lee K, Wu B, Tannyhill R. Standing on the shoulders of giants: Dental students seek academically productive mentors. Oral and Maxillofacial Surgery 2019; Sept 5.

Schulte F, Hasturk H, Hardt M. Mapping relative differences in human salivary gland secretions by dried saliva spot sampling and nanoLC-MS/MS. Proteomics 2019; Sep 2:e1900023.

Shazib M, Muhlbauer J, Schweiker R, Li S, Cutler C, Treister N.Long-term utilization patterns of topical therapy and clinical outcomes of oral chronic graft-versus-host disease. Biology of Blood and Marrow Transplantation 2019; Oct 1.

Villa A, Celentano A, Glurich I, Borgnakke W, Jensen S, Peterson D, Delli K, Ojeda D, Vissink A, Farah C. Response to “prognostic biomarkers in oral leukoplakia”. Oral Diseases 2019; Aug 30.

Wang C, Li C, Krawczyk W, Kim D. Root coverage procedure with connective tissue graft harvested from a distal wedge. Clinical Advances in Periodontics 2016;6(3):134-139.

Yang F, Xiao W, Liu Y, Liu R, Kramer R, Li X, Ajena Y, Baehr C, Rojalin T, Zhang H, Lam K. One-bead one-compound combinatorial library derived targeting ligands for detection and treatment of oral squamous cancer. Oncotarget 2019;10(52):5468-5479.

RESTORATIVE DENTISTRy AND BIOMATERIALS SCIENCES Al-Jewair T, Herbert A, Leggitt V, Ware T, Hogge M, Senior C, Carr R, Da Silva J. Evaluation of faculty mentoring practices in seven U.S. dental schools. Dental Education 2019; Aug 12.

Alshihri A, Kämmerer P, Heimes D, Niu W, Alnassar T, Spector M. Extracorporeal shock wave stimulates angiogenesis and collagen production in facial soft tissue. Surgical Research 2019;245:483-91.

Barbu H, Iancu S, Jarjour Mirea I, Mignogna M, Samet N, Calvo-Guirado J. Management of Schneiderian membrane perforations during sinus augmentation procedures: A preliminary comparison of two different approaches. Clinical Medicine 2019;8(9).

Lee J, Jung S, Wang C, Lee S. Integrated digital and conventional treatment workflow in guided complete mouth implant rehabilitation. Dentistry Journal 2019; 1;7(4).

Peng C, Park S, de Sousa F, Gan H, Lee S, Wang W, Lavender S, Pilch S, Han J. Enhanced teeth whitening by nanofluidic transport of hydrogen peroxide into enamel with electrokinetic flows. Dental Materials 2019; Sep 19.

ORAL AND MAxILLOfACIAL SURgERy Barbu H, Iancu S, Jarjour Mirea I, Mignogna M, Samet N, Calvo-Guirado J. Management of Schneiderian membrane perforations during sinus augmentation procedures. Clinical Medicine 2019; Sep 19;8(9).

Carlson E, Tannyhill R. The growth mindset: A contextualization of faculty development. Oral and Maxillofacial Surgery 2019; Aug 20.

Choi D, Vandenberg K, Smith D, Davis C, McCain J. Is temporomandibular joint arthroscopy effective in managing pediatric temporomandibular joint disorders in the short and long term? Oral and Maxillofacial Surgery 2019; Jul 31.

Jazayeri H, Ganjawalla K, Lee K, Wu B, Tannyhill R. Standing on the shoulders of giants: Dental students seek academically productive mentors. Oral and Maxillofacial Surgery 2019; Sept 5.

Jazayeri H, Kufta K, Lee K, Chuang S, Peacock Z, Ford B. What characteristics do orthodontists desire in orthognathic surgeons? Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology 2019; Jul 3.

4 Research Bulletin • September – October 2019 • Harvard School of Dental Medicine

SCIENCE SPEAKER SERIES11:00 a.m. – 12:00 p.m. in the REB Auditorium • november 14, 2019 Dr. Terrence Capellini (harvard)• December 12, 2019 Dr. Jie Song (uMass)• January 16, 2020 Dr. Eileen Shore (Penn)• February 13, 2020 Dr. Henry Kronenberg (harvard)• March 12, 2020 Dr. Matthew greenblatt (cornell)• april 16, 2020 Dr. Tamara Alliston (ucsF)• May 14, 2020 Dr. Catherine McCusker (uMass)

SCIENCENOVEMBER 14, 2019 • 11AM-12PM

HSDM REB AUDITORIUM • 190 LONGWOOD AVENUE

TERRENCE D. CAPELLINI, PHD

SPEAKER SERIES

Richard B. Wolfe Associate Professor, Department of Human Evolutionary Biology, Harvard University

"Regulatory selection and constraint during humanknee evolution drive modern osteoarthritis risk"

saVe the

DATES

Shu Zhuo, PhD, joined the Yang Lab as a postdoctoral fellow in the department of Developmental Biology. Zhuo earned a PhD in biochemistry and molecular biology from Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, China. His graduate work focused on liver glucose and lipid metabolism. In the Yang Lab, Zhuo is working on

the role of Hippo signaling pathway in liver cancer.

yi fan, DMD, PhD, joined the Yang Lab as a postdoctoral fellow in the department of Developmental Biology. Fan received her DMD and PhD from West China School of Stomatology, Sichuan University, China. Fan’s PhD work focused on the regulation of parathyroid hormone on bone marrow mesenchymal cell fate and

mineral ion homeostasis. In the Yang Lab, she will investigate the molecular and cellular mechanisms of Hippo signaling pathways in mediating mechanotransduction in skeleton.

NEW RESEARCHERS