john j. haddad - weeblyjohnjhaddad.weebly.com › uploads › 2 › 5 › 2 › 0 ›...

-

-

JOHN J. HADDAD Academic Professor and Research Scientist

Biological, Biomedical and Clinical Laboratory Health Sciences, with

Sub-Specialties in Cellular/Molecular Physiology and Immunology

JJH

CV

Biomedical and Clinical Laboratory Sciences – http://johnjhaddad.weebly.com/

JJH CV

Dr. John J. Haddad – Biomedical, Clinical Laboratory and Health Sciences Research Scientist and Educating Professor ––––––––––––––––––––––––

| Biomedical and Clinical Laboratory Sciences – http://johnjhaddad.weebly.com/

Unabridged Academic Curriculum Vitae

JOHN J. HADDAD, B.Sc., M.Sc., Ph.D.

Biomedical, Clinical Laboratory and Health Sciences Research Scientist and Professor of Science

The FBC Bldg., Salim Al-Bustani St., Watwat, El-Zarif, Beirut, Lebanon

Telephone Contacts: +

Email Contacts: [email protected] ; [email protected] ; [email protected]

Official Website: http://johnjhaddad.weebly.com/

OBJECTIVES AND AIMS

BIOMEDICAL RESEARCH AND DEVELOPMENT, LABORATORY MANAGEMENT AND TECHNOLOGY

(ACADEMY/INDUSTRY); ADMINISTRATIVE/PROFESSORSHIP IN TEACHING AND LEADERSHIP (ACADEMY).

EDUCATION AND TRAINING

PostDoc. Postdoctoral Fellow September, 2001 – August, 200 [University of California, San Francisco, CA, USA]

Postdoctoral scholar and fellow on a National Institutes of Health (NIH) training fellowship award in Cellular and

Molecular Neurophysiology and Biomedicine (Neuroimmunology), Cellular and Molecular Neurophysiology Research

Division, Severinghaus-Radiometer Research Laboratories, Department of Anesthesia and Perioperative Care, School of

Medicine, University of California (UCSF), San Francisco, California, USA.

Postdoctoral Research Theme

“The role of MAPK (mitogen-activated protein kinase) signaling pathways in determining cellular death and survival in hypoxia: Emerging pharmacological targets for therapeutic intervention,” and “The role of intracellular Ca signaling pathways

in neuroprotection during hypoxia and hypoxia-reoxygenation.”

Ph.D. Doctor of Philosophy (Doctor of Science) October, 199 – August, 2001 [University of Dundee, Scotland, UK]

Cellular and Molecular Physiology and Immunology (Respiratory Physiology and Medicine), Division of Pulmonary

Medicine and Oxygen Sensing, Tayside Institute of Maternal and Child Health, Department of Maternal and Child Health

Sciences, Faculty of Medicine, Ninewells Hospital and Medical School, University of Dundee (UoD), Dundee, Scotland,

UK.

mailto:[email protected]



http://johnjhaddad.weebly.com/



Doctorate Research Thesis Title

“Oxygen-dependent regulation of redox-sensitive transcription factors HIF- - (hypoxia-inducible factor- ) and NF-B

(nuclear factor-B) in the developing perinatal lung: Signaling potential of apoptosis and an association between oxidative

stress and pro-inflammatory cytokines.”

M.Sc. Master of Science October, 1993 – February, 1996 [American University of Beirut, Lebanon]

Biology (Neuroimmunology), American University of Beirut (AUB), Beirut, Lebanon (Chartered, New York, NY, USA).

Master of Science Research Thesis Title

“Hyperalgesia induced by local endotoxin injections and its modulation by various anti-inflammatory and analgesic drugs.”

B.Sc. Bachelor of Science October, 1989 – February, 1992 [American University of Beirut, Lebanon]

Pre-medical Biology, American University of Beirut (AUB), Beirut, Lebanon (Chartered, New York, NY, USA).



PROFILE

Renowned Biomedical and Clinical Laboratory Associate Professor with ten- years of education and research experience. Adept in performing administrative responsibilities, educational leadership and research development; knowledgeable in areas of Cellular/Molecular Physiology and Immunology with clinical relevance to biomedical laboratory; and excel in analyzing and solving problems with various biomedical controls and systems.

KEY SKILLS

PROFESSIONAL EXPERIENCE (CONTINUED)

LEBANESE INTERNATIONAL UNIVERSITY — Beirut, Lebanon

Program Coordinator, Researcher & Assistant/Associate Professor, 2003 to 2009

Chairman, University Research Council

Key Results:

Advisor and instructor in biological and biomedical sciences, centralized in lecturing on General Biology I (BIOL 200; 4.0); Cell and Molecular Biology (BIOL 275; 4.0); Human Anatomy and Physiology (BIOL 345; 4.0); Genetics (BIOL 365; 3.0); Microbiology (BIOL 385; 4.0); Immunology (BIOL 425; 3.0); Biomedical Science Seminar (BIOL 490; 1.0); Epidemiology and Biostatistics (BMED 255; 3.0); Basic Health Care and Medical Terminology (BMED 310; 3.0); Hematology (BMED 360; 3.0); Medical Microbiology (BMED 430; 4.0); Carcinogenesis and Oncology (BMED 435; 3.0); Pathophysiology (BMED 445; 4.0); Clinical Hematology and Hemostasis (BMED 475; 3.0); Biotechnology (BIOC 445; 3.0); Molecular Genetics (BIOC 450; 3.0); Immunohematology (MEDL 545; 3.0); and Pharmaceutical Biotechnology (PHAR 530; 2.0).

UNIVERSITY OF BALAMAND — Beirut/Tripoli, Lebanon

Researcher & Lecturer, 2005 to 2010

Department of Medical Laboratory Sciences, Faculty of Health Sciences (FHS), University of Balamand (UoB), St. George Hospital and Medical Complex, Aschrafieh, Beirut, Lebanon.

Key Results:

Supervised and instructed graduate students in Applied Molecular Biology (CLAS 303; 3.0); Cancer Genetics (CLAS 335; 1.0); Genomics (CLAS 336; 3.0); and Medical Genetics (CLAS 338; 3.0). Supervised and instructed undergraduate students in General Biology – Genetics (FHSC 200; 4.0); Cell Biology (FHSC 208; 3.0); Basic Immunology and Hematology (MALB 212; 4.0); Clinical Immunology and Hematology (MLAB 222; 4.0); Molecular Biology (MLAB 230; 3.0); Seminars in Medical Laboratory Sciences (MLAB 231; 3.0); Applied Clinical Immunology and Endocrinology (MLAB 255; 1.0); and Clinical Pathology – Immunology and Serology (MLAB 260; 4.0).

EDUCATION & CREDENTIALS

Postdoctoral Fellow, University of California at San Francisco

(UCSF)

2001 to 2003

Doctor of Philosophy (Doctor of Science), Ph.D., University of Dundee, Scotland, UK

1998 to 2001

Premedical Biology (B.Sc.) & Biology (Neuroimmunology; M.Sc.) American University of Beirut, Beirut, Lebanon

1989 to 1996

– Member of Professional & Academic Societies – Principal Investigator in Project Grants & Extramural Funds

– Advisory/Consultant Member

– Reviewer for Specialized Scientific Journals

– Project Grants & Extramural Funds Review

– Editorial Expertise

– Editorial Board

– Network of Healthcare Advisors

– Science Development Network

– Medical Laboratory Consultant

PROFESSIONAL EXPERIENCE

BEIRUT ARAB UNIVERSITY (BAU) — Beirut, Lebanon

Chairman and Associate Professor, 2010 to Present

Administrative/educational responsibilities affiliated with the Department of Medical Laboratory Technology (MLT), Faculty of Health Sciences (FHS) for MLT undergraduate/postgraduate programs.

Member and General Secretary of the FHS Council, recommended by Dean and appointed by the President of BAU since September, 2010.

Member of the FHS Quality Assurance and Accreditation (QAA) committee since September, 2010.

Chair of the QAA since September, 2011.

Key Results:

Supervised and instructed undergraduate students in Principles of Anatomy and Physiology (HESC 101; 3.0); Specimen Preparation (MLAB 201; 2.0); Quality Management for Medical Laboratory (MLAB 206; 2.0); Immunology and Serology (MLAB 301; 2.0); Molecular Genetics (MLAB 302; 3.0); Medical Bacteriology (MLAB 306; 3.0); Cancer Biology and Biomedicine (MLAB 412; 2.0); and Biotechnology for Medical Laboratory (MLAB 413; 2.0).

AMERICAN UNIVERSITY OF SCIENCE AND TECHNOLOGY — Beirut, Lebanon

Program Coordinator, Researcher & Associate Professor, 2009 to 2010

Interdisciplinary Research and Development Fellow, American University of Science and Technology (AUST), Aschrafieh, Beirut, Lebanon.

Coordinator and chair of the Biological (BIO) and Clinical Laboratory Science (CLS) undergraduate programs, Department of Clinical Laboratory Science, Faculty of Health Sciences (FHS), American University of Science and Technology (AUST), Aschrafieh, Beirut, Lebanon.

Key Results:

Supervised and instructed undergraduate students in General Biology (BIO 102; 3.0); Cells and Molecules (BIO 210; 3.0); Microbiology (BIO 310; 3.0); and Clinical Virology (CLS 452; 3.0).

The FBC Building Beirut, 3269 (961) 01-37 81 59 / 03-86 33 84 / 71-91 75 91 [email protected]

John J. Haddad Biomedical, Clinical Laboratory and Health Sciences

Research Scientist and Professor of Science

PROFESSIONAL EXPERIENCE – Research, Management and Development Scientist, and Tenure-Track Faculty Professor

Workplace Wisdom

Learning about the culture, structure, and management of your company will help you perform your job smoother and to the best of your ability.



Academic Profile at a Glance

Chairman Beirut Arab University, Beirut, Lebanon – September, 2010 – Current Status: Chairman

Associate Professor Beirut Arab University, Beirut, Lebanon – September, 2010 – Current Status: Associate Professor

Associate Professor American University of Science & Technology, Lebanon – February, 2009 – September, 2010 Status: Associate Professor

Chairman Lebanese International University, Beirut, Lebanon – January, 2006 – February, 2009 Status: Chairman

Associate Professor Lebanese International University, Beirut, Lebanon – October, 2006 – February, 2009 Status: Associate Professor

Assistant Professor Lebanese International University, Beirut, Lebanon – October, 2004 – September, 2006 Status: Assistant Professor

Lecturer University of Balamand, Beirut/Tripoli, Lebanon – February, 2004 – Current Status: Lecturer Haigazian University, Beirut, Lebanon – October, 2003 – February, 2005 Status: Lecturer

Lebanese International University, Beirut, Lebanon – October, 2003 – September Status: Lecturer

Post-Doctoral Fellow University of California, San Francisco, CA, USA – September, 2001 – August, 2003 Status: PDRF

PhD Candidate University of Dundee, Dundee, Scotland, UK – October 1997 – July, 2001 Status: PhD

MSc Candidate American University of Beirut, Beirut, Lebanon – October, 1993 – February, 1996 Status: MSc

BSc Candidate American University of Beirut, Beirut, Lebanon – October, 1989 – February, 1992 Status: BSc

Chairman and Associate Professor Sept. 2010 – Current

Department of Medical Laboratory Technology, Faculty of Health Sciences (FHS), Beirut Arab University (BAU), Beirut,

Lebanon.

Member and General Secretary of the FHS Council, recommended by Dean and appointed by the President of BAU since

September, 2010.

Member of the FHS Quality Assurance and Accreditation (QAA) committee since September, 2010.

Chair of the QAA since September, 2011.

Chairman/coordinator of the Medical Laboratory Technology department for MLT undergraduate/postgraduate programs.

Supervised and instructed undergraduate students in Principles of Anatomy and Physiology (HESC 101; 3.0); Specimen

Preparation (MLAB 201; 2.0); Quality Management for Medical Laboratory (MLAB ; ; Immunology and Serology

(MLAB ; ; Molecular Genetics (MLAB 302; 3.0); Medical Bacteriology (MLAB Cancer Biology and

Biomedicine (MLAB 412; 2.0); and Biotechnology for Medical Laboratory (MLAB 413; 2.0).

Program Coordinator and Researcher Feb. 2009 – Sept. 2010

Interdisciplinary Research and Development Fellow, American University of Science and Technology (AUST), Aschrafieh,

Beirut, Lebanon.

Coordinator and chair of the Biological (BIO) and Clinical Laboratory Science (CLS) undergraduate programs, Department of

Clinical Laboratory Science, Faculty of Health Sciences (FHS), American University of Science and Technology (AUST), Aschrafieh,

Beirut, Lebanon.

Associate Professor Feb – Sept. 2010

Department of Clinical Laboratory Science, Faculty of Health Sciences (FHS), American University of Science and Technology

(AUST), Aschrafieh, Beirut, Lebanon.

Supervised and instructed undergraduate students in General Biology (BIO 102; 3.0); Cells and Molecules (BIO ;

Microbiology (BIO and Clinical Virology (CLS

Chairman, University Research Council Jan. 2006 – Feb. 2009

The university research council (URC) is an organizing and steering committee at the Lebanese International University (LIU)

that oversees promoting research interests, funding high-caliber research applications and accruing extramural grants, domestically

and internationally. The main objective of the URC is to establish a competitive and highly-credible research center in basic and

clinical sciences at the university.

Associate Professor Oct. 2006 – Feb. 2009



Departments of Biology and Biomedical Sciences, Faculty of Arts and Sciences, Lebanese International University (LIU),

Mousseitbeh, Al-Mazraa, Beirut, Lebanon. (Courses taught jibes with what is therein stated down below.)

Assistant Professor Oct. – Sept. 2006

Departments of Biology and Biomedical Sciences, Faculty of Arts and Sciences, Lebanese International University (LIU),

Mousseitbeh, Al-Mazraa, Beirut, Lebanon.

Advisor and instructor in biological and biomedical sciences, centralized in lecturing on General Biology I (BIOL 200; 4.0);

Cell and Molecular Biology (BIOL 275; 4.0); Human Anatomy and Physiology (BIOL 345; 4.0); Genetics (BIOL 365;

Microbiology (BIOL 385; 4.0); Immunology (BIOL 425; 3.0); Biomedical Science Seminar (BIOL 490; 1.0);

Epidemiology and Biostatistics (BMED 255; 3.0); Basic Health Care and Medical Terminology (BMED 310; 3.0);

Hematology (BMED 360; 3.0); Medical Microbiology (BMED 430; Carcinogenesis and Oncology (BMED 435; 3.0);

Pathophysiology (BMED 445; 4.0); Clinical Hematology and Hemostasis (BMED 475; 3.0); Biotechnology (BIOC 445;

Molecular Genetics (BIOC 450; 3.0); Immunohematology (MEDL 545; 3.0); and Pharmaceutical Biotechnology

(PHAR 530; 2.0).

Lecturer Oct. 2005 – Sept. 2010

Department of Medical Laboratory Sciences, Faculty of Health Sciences (FHS), University of Balamand (UoB), St. George

Hospital and Medical Complex, Aschrafieh, Beirut, Lebanon.

Supervised and instructed graduate students in Applied Molecular Biology (CLAS 30 ; Cancer Genetics (CLAS 335;

Genomics (CLAS 3 ; and Medical Genetics (CLAS 338; 3.0).

Supervised and instructed undergraduate students in General Biology – Genetics (FHSC 200; 4.0); Cell Biology (FHSC 208;

Basic Immunology and Hematology (MALB 212; 4.0); Clinical Immunology and Hematology (MLAB 222; 4.0);

Molecular Biology (MLAB 230; 3.0); Seminars in Medical Laboratory Sciences (MLAB 231; 3.0); Applied Clinical

Immunology and Endocrinology (MLAB 255; 1.0); and Clinical Pathology – Immunology and Serology (MLAB .

Lecturer Feb. 200 – Jan. 2006

Department of Clinical Laboratory Science, Faculty of Sciences, American University of Science and Technology (AUST),

Aschrafieh, Beirut, Lebanon.

Supervised and instructed undergraduates and laboratory science students in Biostatistics and Epidemiology (BIOL 320;

Lecturer Feb. 2004 – Sept. 2007

Department of Biology, Faculty of Sciences (FOS), University of Balamand (UoB), Balamand, Koura, Tripoli, Lebanon.

Supervised and instructed undergraduates and premedical students in Immunobiology (BIOL 229; 3.0); Molecular Biology

(BIOL 285; 3.0); Molecular Biology Laboratory (BIOL 286; 1.0); and Techniques in Biological Research (BIOL 308; 3.0).

Lecturer Oct. 2003 – Feb. 2005

Department of Natural Sciences, Faculty of Arts and Sciences, Haigazian University (HU), Rue Mexique, Kantari, Beirut,

Lebanon.

Supervised and instructed undergraduate and medical laboratory students in Immunology (BIOL /MLS 207 ); Plant

Physiology (BIOL . ); Botany (BIOL ); Cell Biology (BIOL ); and Epidemiology and Biostatistics

(MLS 225; 3 ).



Lecturer Oct. 2003 – Sept. 2004

Departments of Biology and Biomedical Sciences, Faculty of Arts and Sciences, Lebanese International University (LIU), Al-

Mousseitbeh, Mazraa, Beirut/Saida, Lebanon.

Supervised and instructed biology, biochemistry, pharmacy and biomedical sciences students in Introductory Biology I/II

(BIOL 100/150; 4.0); General Biology I/II (BIOL 200/250; 4.0); Cell and Molecular Biology (BIOL 275; 4.0); Human

Anatomy and Physiology (BIOL 345; 4.0); Genetics (BIOL 365; ; Microbiology (BIOL 385; 4.0); Immunology (BIOL

; Biomedical Science Seminar (BIOL 490; 1.0); Epidemiology and Biostatistics (BMED ; Hematology

(BMED 360; 3.0); Pathophysiology (BMED ; Molecular Genetics (BIOC ; Biotechnology (BIOC 445;

; and Pharmaceutical Biotechnology (PHAR 530; 2.0).

Research Scientist (National Institutes of Health [NIH] Postdoctoral Scholar) Sept. 2001 – Aug

Severinghaus-Radiometer Research Laboratories, Cellular and Molecular Neurophysiology Research Division, Department of

Anesthesia and Perioperative Care, School of Medicine, University of California (UCSF), San Francisco, CA, USA.

Investigated pharmacological patterns of mitogen-activated protein kinases signaling and their enzymatic role in

neuroprotection in anoxia-intolerant species, such as rats and mice, and in anoxia-tolerant species, such as the Western-

painted turtles.

Evaluated subcellular N-methyl-D-aspartate and neurotransmitter receptor regulation, calcium signaling and protein

kinase/transcription in ischemia/reperfusion and hypoxia-induced neurological injury.

Developed extensive expertise in diverse techniques and methods of analyses, including, gene micro-array system, ELISA,

cell membrane receptor/protein signaling, Western/Northern/Southern analysis, electrophoresis, immunocytochemistry,

micro-histology staining, immunohistology, perfusion/embedding/cryosectioning, calcium imaging, HPLC, mass

spectrophotometry, immunofluorescence and cell plasmid transfection/DNA-RNA analysis assays.

Research Associate (Ph.D. Candidate and Postdoctoral Research Fellow) Nov. 1998 – Aug. 2001

Division of Molecular Biology, Oxygen Signaling and Pulmonary Physiology Group, Tayside Institute of Maternal and Child

Health, Ninewells Hospital and Medical School, University of Dundee, Dundee, Scotland, UK.

Provided leadership and biotechnology expertise to research groups focused on the differential regulation of oxygen-sensitive

transcription factors in the lung and alveolar epithelium.

Designed experimentations and methodology to study the redox variations and cytokine-dependent pathways associated with

respiratory distress syndrome (RDS) in pre-term infants.

Directed molecular physiology and cellular Biology research that utilized diverse techniques and state-of-the-art approaches,

including: Enzyme-linked immunosorbent assay (ELISA), electrophoretic mobility shift assay (EMSA), in situ hybridization,

histochemistry and immunofluorescence, Western/Northern/Southern blotting, PCR/RT-PCR, RNAase protection assays,

transfection/infection and plasmid engineering, DNA laddering, nick-end labeling and terminal transferase immonoreactivity,

fluorescent microscopy, cytokine-related immune assays, apoptosis-related techniques, antibody production, vaccine/drug

targeting, metabolism and disposition, and electrophysiology.

Undertaken peer-reviewed and published research experimental results in domestically and internationally renowned

journals, including, but not limiting to: Am. J. Physiol.; Am. J. Respir. Cell Mol. Biol.; Biochem. Biophys. Res. Commun.;

Biochem. J.; Biochem. Pharmacol.; Brain Res.; Br. J. Pharmacol.; Cell. Immunol.; Cell. Signal.; Crit. Care; Curr. Drug

Targets; Curr. Immunol. Rev.; Curr. Opin. Investig. Drugs; Cytokine; Cytokines Cell. Mol. Therap.; Eur. Cytokine Netw.;

FEBS Lett.; Free Radic. Biol. Med.; Int. Immunopharmacol.; J. Biol. Chem.; J. Med. Case Reports.; J. Neuroimmunol.; J.

Orthop. Surg.; J. Pharmacol. Exp. Therap.; J. Physiol.; Mol. Immunol.; Neuropharmacology; Prog. Neurobiol.; Respir.

Res.; amongst others.

Presented research findings at several scientific meetings and conferences: American Physiological Society, Federation of the

American Societies for Experimental Biology, Society for Neuroscience, and others (see p. 8).

Research Assistant Oct. 1995 – Aug. 1998

Departments of Biology (Faculty of Arts and Sciences), Internal Medicine, Human Morphology and Physiology (Faculty of

Medicine), American University of Beirut, Beirut, Lebanon (New York, NY).

Designed and conducted experiments to study thermal and mechanical hyperalgesia in laboratory animals, using different

protocols for pain assessment and measurement.



Established efficient animal surgical procedures, such as, thymectomy, sympathectomy, cordotomy, vagotomy, and brain

electrolytic lesions.

Examined the mechanisms of inflammatory hyperalgesia to understand and enhance alleviation and treatment of pain caused

by inflammation (neurogenic inflammation).

Performed ELISA and related immunoassays for the measurement of cytokines and growth factors in tissues, sera and whole

blood.

Graduate Assistant Oct. 1993 – June 1995

Department of Biology, Faculty of Arts and Sciences, American University of Beirut, Beirut, Lebanon (New York, NY, USA).

Supervised, instructed and graded General Biology and Physiology courses for undergraduate students.

Non-Academic High School and College Teaching Appointments Oct. 1992 – Sept. 1998

Associate Teacher for Math and Sciences (Intermediate I IV; Grades VI IX) Near East Evangelical School,

Mousseitbeh, Beirut, Lebanon (October 1, 1992 September 30, 1993).

Associate Teacher for Sciences (Intermediate IV) and SAT-II (Secondary I, Scientific and Literary) Rawdah High School,

Verdun, Beirut, Lebanon (October 1, 1996 September 30, 1997).

Associate Teacher for Sciences & Biology (Intermediate III IV); Advisor and Assistant Head of Division Saint Mary’s

Orthodox College, Ras-Beirut, Beirut, Lebanon (October 1, 1997 September 30, 1998).

ADDITIONAL PROFESSIONAL EXPERTISE

- Member of Professional and Academic Societies: American Chemical Society, The Physiological Society (UK), American

Physiological Society, Society for Experimental Biology (UK), National Geographic Society, International Cytokine Society,

Neuroscience Society, Federation of the Association of Societies of Experimental Biology (FASEB), and New York

Academy of Science.

- Principal Investigator in Project Grants and Extramural Funds: The National Institute for Biological Standards and

Controls (NIBSC), England, UK; Tenovus for Supporting Medical Research, Scotland, UK; National Institutes of Health

(NIH), USA.

- Advisory/Consultant Member: Consultant for Current Drugs Ltd.: Investigational Drugs Database Company, specialized in

pharmaceutical industry, headquartered in London, UK.

- Reviewer for Specialized Scientific Journals: Antioxidants & Redox Signaling; BMC Cardiovascular Disorders; Cell

Biochemistry & Biophysics; Cytokine; Environmental Science & Technology; Free Radical Biology & Medicine; Journal of

Neurochemistry; Journal of Neuroimmunology; Journal of Proteome Research; Proceedings of the National Academy of

Sciences, USA; amongst others.

- Project Grants and Extramural Funds Review: The American Heart Association (AHA), Dallas, TX, USA; The

Wellcome Trust (WT), London, England, UK; The Arthritis Research Campaign (ARC), Chesterfield, Derbyshire, England,

UK; Ministry of Education, Youth and Sports of the Czech Republic, Department of Research and Development Support,

Karmelitská, Prague, Czech Republic; Sheffield Hospitals Charitable Trust, Sheffield, England, UK; The Medical Research

Council (MRC), London, UK; The Medical Research Scotland (Scottish Hospital Endowments Research Trust; SHERT),

Edinburgh, UK. Grants refereed are entitled as follows:

April – 2007; The University Research Council – Lebanese International University (Lebanon): Constructing doubly

stochastic matrices for the inverse spectral problem.

March – 2007; The University Research Council – Lebanese International University (Lebanon): Theoretical

electronic structure investigation of low lying states of diatomic molecules.

January – 2007; The Medical Research Scotland – SHERT (UK): Monocyte-fibroblast interactions in pulmonary

fibrosis.

March – 2006; The Wellcome Trust (UK): The role of circulating monocytes and HIF-1 in a multi-hit model of

acute lung injury.

February – 2006; The Medical Research Council (UK): Non-hypoxic regulation of HIF hydroxylation.

November – 2005; Sheffield Hospitals Charitable Trust (UK): Nuclear translocation and processing of pro-IL- .

June – The Arthritis Research Campaign (UK): The effects of hypoxia on cell adaptation and function.

December – The Wellcome Trust (UK): The IKK-NF-B pathway as a ‘master switch’ in mediating a global

inflammatory response within the airway epithelium.



June – 2002; The American Heart Association (USA): The role of MAPK signaling pathways in determining cellular

death or survival in hypoxia: Emerging pharmacological targets for therapeutic intervention.

- Editorial Expertise: Field editor for Springer-Verlag (Heidelberg, Germany; New York, USA) in the creation of the

‘Encyclopedic Reference of Neuroscience’ – Neuroimmunology.

- Editorial Board: Serving as a member on board of the following journals – NanoScience and NanoTechnology Journal

(Trade Science, Inc.).

- Network of Healthcare Advisors: A consultant for an exclusive community of academic and industry professionals who

provide consulting services to the financial industry (http://www.networkofadvisors.com).

- Science Development Network: A consultant for the network in sharing science and technology in Middle East-based

institutions (http://www.sciencedev.net).

- St. Elias Medical Laboratories: Consultant and lecturer for medical laboratory specialists and technologists in norms with

ISO licensing and accreditation standards (http://www.stelielab.com).

OTHER TECHNICAL EXPERTISE

Strong background in the characterization, purification and testing of proteins and enzyme-related cofactors

(Biomedical/Biochemical Pharmacology).

Extensive experience in gel electrophoresis, DNA/RNA assays, microscopy, cell preparation and culturing (Cell Physiology).

Extensive experience in immunology techniques, cytokine assessment, inflammation and apoptosis-related assays (Cellular

Immunology and Hematology).

Skilled knowledge in performing plasmid analysis, cell culture and transfection and molecular biology technical assays

(Cellular and Molecular Biology).

Professional knowledge of electrophysiology, immunofluorescence, immunohistology and related techniques

(Neurophysiology and Immunology).

OTHER SKILLS

Computer and statistical skills:

MSWord, Excel, PowerPoint, Publisher, ChemDraw, CorelDraw, SigmaStat, SPSS, Professional PDF and Adobe Photoshop.

Conducted administrative work for data assessment, statistical analysis, graphic design, and professional writing.

Leadership skills:

Supervised and instructed students for university entrance examinations, including FEE, SEE, SQ and SAT-II, at the

American University of Beirut and Lebanese American University preparatory centers, Beirut, Lebanon.

Supervised and trained medical students in Molecular Biology, at the University of Dundee, Scotland, UK.

Mentored and trained high school and college students at University of California, San Francisco, CA, USA, resulting in

training and motivation for the field of Molecular Biology.

HONORS, AWARDS AND RECOGNITIONS

American University of Beirut awarded studentship for the premedical Biology major.

American University of Beirut graduate assistantship award for the degree of Master of Science.

American University of Beirut research fellowship at the departments of Biology and Human Morphology.

Georges John J. Livanos (London) Ph.D. fellowship at the Tayside Institute of Child Health, Ninewells Hospital

and Medical School, University of Dundee, Dundee, Scotland, UK.

NIH Postdoctoral research fellowship at the Severinghaus-Radiometer Research Laboratories, Department of

Anesthesia and Perioperative Care, University of California, San Francisco, CA, USA.

2006 – International recognition as an outstanding scientist, documented in the 1st edition of the major academic

reference of ‘Marquis Who’s Who of Emerging Leaders, ’, New Providence, NJ, USA.

2009 – Acclaimed field editor of Neuroimmunology in the renowned Encyclopedia of Neuroscience, published with

Springer-Verlag.

http://www.networkofadvisors.com/

http://www.sciencedev.net/

http://www.stelielab.com/



FELLOWSHIPS AND TRAVEL AWARDS

The University of Dundee, Ninewells Hospital and Medical School, annual travel award to outstanding young

scientists. This fellowship was awarded to attend Experimental Biology-2000 in San Diego, California, USA.

Award £500.00 ( $ ).

The American Physiological Society, Bethesda, MD (USA), travel award for attending the joint annual meeting

with the Scandinavian Physiological Society in Amsterdam, Sweden. Award £525.00 ( $ ).

The Wellcome Trust, London (UK), travel award for attending the joint annual meeting of the Federal

Association for the Societies of Experimental Biology (FASEB) in Orlando, Florida, USA. Award £800.00 (

The Physiological Society, London (UK), travel award, under the Affiliate Travel Grant Scheme, for attending

the joint annual meeting of the Federal Association for the Societies of Experimental Biology (FASEB) in

Orlando, Florida, USA. Award £600.00 ( $ ).

PROJECT GRANTS AND EXTRAMURAL FUNDS

Jan. 20 – Current Supporting Body: Intramural funding at the Faculty of Health Sciences, Beirut Arab University,

Beirut, Lebanon. Grant award value: $ ,

Project Title: “Hypertension and correlational obesity biomarkers among academic students in

Lebanon.”

Principal Investigators: Prof. Fikrat El-Sahn and Dr. John J. Haddad at the Departments of Nutrition

and Dietetics, and Medical Laboratory Technology, Faculty of Health Sciences, Beirut Arab

University, Beirut, Lebanon.

Oct. 200 – Feb. 2009 Supporting Body: The University Research Council (URC) of the Lebanese International University

(LIU). Grant award value ,

Project Title “The role of MAPK signaling pathways in determining cellular death or survival in

hypoxia: Emerging pharmacological targets for therapeutic intervention ”

Principal Investigator: Dr. John J. Haddad, Cellular and Molecular Signaling research group,

division of Biological sciences, departments of Biology and Biomedical Sciences, Faculty of Arts and

Sciences, Lebanese International University, Beirut, Lebanon.

Oct. 1999 – Jun. 2000 Supporting Body: The National Institute for Biological Standards and Controls (NIBSC) (Dr.

Stephen Poole, NIBSC, England, UK), in collaboration with the American University of Beirut

(Professors Nayef E. Saadé and Bared Safieh-Garabedian, Beirut, Lebanon). Grant award value:

£6,000 ( $ ,

Projects Titles: “I. Chemioxyexcitation (pO /ROS) dependent release of IL- , IL-6 and TNF-:

Evidence of cytokines as oxygen-sensitive mediators in the alveolar epithelium ” “II. Thiol

regulation of pro-inflammatory cytokines revealed a novel immunopharmacological potential of

glutathione in the alveolar epithelium ”

Principal Investigator: Dr. John J. Haddad at the Center for Research into Human Development,

Tayside Institute of Maternal and Child Health, Faculty of Medicine, Ninewells Hospital and Medical

School, University of Dundee, Dundee, Scotland, UK.

Jan. 2000 – Dec. 2000 Supporting Body: Tenovus-Scotland for Supporting Medical Research. Grant award value: £5,000

( $ ,

Project Title: “Cytokine-mediated activation of HIF- and NF-B in alveolar epithelia: Signaling

pathways of apoptosis in oxidative stress ”



Principal Investigator: Dr. John J. Haddad at the Center of Research for Human Development,

Tayside Institute of Maternal and Child Health, Faculty of Medicine, Ninewells Hospital and Medical

School, University of Dundee, Dundee, Scotland, UK.

SPECIALIZED MEETINGS, WORKSHOPS AND SYMPOSIA ATTENDED, Documented as of 1999

The Physiological Society semi-annual meeting in Manchester, England, UK.

The 9th

Postgraduate Research Symposium in Dundee, Scotland, UK.

The Experimental Biology annual meeting in San Diego, California, USA.

The 10th

Postgraduate Research Symposium in Dundee, Scotland, UK.

The American Physiological Society and Scandinavian Physiological Society joint annual meeting in Stockholm, Sweden.

The Physiological Society annual meeting in London, England, UK.

The Experimental Biology annual meeting in Orlando, Florida, USA.

The Biochemical Society annual meeting in Bristol, England, UK.

The International Society of Neuroimmunology 6th

International Congress in Edinburgh, Scotland, UK.

The 17th

Transatlantic Airway Conference in Lucerne, Switzerland.

The University of California multi-campus workshop on “Oxygen sensing and adaptation mechanisms” in Riverside,

California, USA.

The Society for Neuroscience annual meeting in Orlando, Florida, USA.

The University of Balamand, Faculty of Health Sciences, Medical Laboratory Sciences graduate program workshop on

“First curriculum review” in Beirut, Lebanon.

The University of Balamand, Faculty of Health Sciences, Medical Laboratory Sciences graduate program workshop on

“Second curriculum review” in Beirut, Lebanon.

The 1st international conference on “Effective teaching and learning in higher education”, American University of Beirut,

Beirut, Lebanon.

The 1st international conference on “Towards a comprehensive system for quality assurance of higher education in

Lebanon”, UNESCO Palace, Beirut, Lebanon.

Training workshop on “Communication skills in higher academia”, El-Meouchy Education Consultancy, Beirut Arab

University, Beirut, Lebanon.



PRESENTATIONS AND PUBLICATIONS

Invited Seminars, Symposia and Lectures at Domestic and International Conferences, Workshops and Academic Venue

Meetings, Documented as of

Departments of Human Morphology and Physiology, Faculty of Medicine, and Department of Biology, Faculty of Arts and

Sciences, American University of Beirut, Beirut, Lebanon “Oxygen-sensing mechanisms in the developing lung:

Regulation of gene transcription ”

Tayside Institute of Maternal and Child Health, Faculty of Medicine, University of Dundee, Dundee, Scotland, UK “Redox

regulation of HIF- and NF-B in the alveolar epithelium ”


Sciences, American University of Beirut, Beirut, Lebanon “Redox regulation of oxygen-sensitive transcription factors ”

Department of Medicine, National Jewish Medical and Research Center, global leader in lung, allergic and immune

diseases, Denver, Colorado, USA “The role of reactive oxygen species in inducing a pro-inflammatory signal:

Therapeutic implications ”

Developmental Biology Program, Children’s Hospital Los Angeles Research Institute, Smith Research Tower, University

of Southern California School of Medicine (UCLA), Los Angeles, California, USA. “Redox regulation of pro-

inflammatory cytokines in the developing lung ”

Division of Molecular Cardiovascular Biology, The Children’s Hospital Research Foundation, Children’s Hospital Medical

Center, Cincinnati, Ohio, USA “Oxygen sensing and redox mechanisms in the perinatal airway epithelium ”

Boehringer Ingelheim International GmbH, Transatlantic Airway Conference (17th

TAC annual meeting), Lucerne,

Switzerland “Redox and oxidant-mediated regulation of apoptosis signaling pathways ”

Division of Pulmonary, Critical Care and Occupational Medicine, Department of Internal Medicine, Health Sciences

Center, School of Medicine, Saint Louis University, Saint Louis, Missouri, USA “Antioxidant/prooxidant mechanisms in

the regulation of redox-sensitive transcription factors, apoptosis signaling cofactors and inflammation ”

Programs in Pharmacology and Toxicology, Department of Pharmaceutical Sciences, College of Pharmacy, Health

Sciences Center, University of Oklahoma, Oklahoma City, Oklahoma, USA “Immunopharmacologic

antioxidant/prooxidant mechanisms in the regulation of redox-sensitive transcription factors, apoptosis signaling

cofactors and inflammation ”

Center for Environmental Health Sciences, Department of Pharmaceutical Sciences, University of Montana, Missoula,

Montana, USA “Antioxidant/prooxidant mechanisms in the regulation of redox-sensitive transcription factors, apoptosis

signaling cofactors and inflammation ”

Spinal Cord and Brain Injury Research Center, Sanders Brown Center in Aging, University of Kentucky, Lexington,

Kentucky, USA “Antioxidant/prooxidant mechanisms in the regulation of redox-sensitive transcription factors,

apoptosis signaling cofactors and inflammation ”


Sciences, American University of Beirut, Beirut, Lebanon “Antioxidant/pro-oxidant mechanisms in the regulation of

transcription factors, apoptosis and inflammation ”

Departments of Biology and Biomedical Sciences, Faculty of Arts and Sciences, and Faculty of Pharmacy, Lebanese

International University, Beirut, Lebanon “Oxygen, oxygenes and gene regulation: Glutathione antioxidant therapy ”

Department of Clinical Laboratory Sciences, American University College of Sciences and Technology, Beirut, Lebanon.

“Oxidative stress and the molecular regulation of inflammation ”



Department of Clinical Laboratory Sciences, Faculty of Health Sciences, St. George Medical Center, University of

Balamand, Aschrafieh, Beirut, Lebanon. “Diagnosis and prevention of viral hepatitis: Cutting edge immunologic and

molecular perspectives.”

Department of Biology, Faculty of Sciences, University of Balamand, El-Kurah, Tripoli, Lebanon “Microarray technology

and its molecular and clinical applications ”


Balamand, Aschrafieh, Beirut, Lebanon. “Apoptosis and gene regulation: A view on embryogenesis signaling

transduction pathways.”


Balamand, Aschrafieh, Beirut, Lebanon. “Clinical laboratory sciences graduate program: First curriculum review.”

Department of Sciences, Faculty of Natural and Applied Sciences, Notre Dame University, Zouk Mosbeh, Louaize,

Lebanon “Physiologic oxygen sensing, oxygenes and inflammation ”

Department of Medical Laboratory Technology, Faculty of Health Sciences, Beirut Arab University, Beirut, Lebanon.

“Quality assurance and management in the medical laboratory ”

St. Elias Medical Laboratories, Antelias, Lebanon “Diagnostic protein electrophoresis and immunofixation ”

Department of Medical Laboratory Technology, Faculty of Health Sciences, Beirut Arab University, Beirut, Lebanon.

“Diagnosis and prevention of viral hepatitis ”



Published Abstracts of Domestic and International Conferences and Meetings, Documented as of

Safieh-Garabedian B., Kanaan S.A., Haddad J.J., Malik S., Abdelnoor A., Saadé N.E., and Jabbur S.J.: Hyperalgesia produced

by endotoxin (ET) injections: A new model for localized inflammatory pain in rats and mice. Society for Neuroscience Abstracts,

21: 643, 1995 (Sacramento, California, USA).

Barbour E.K., Hamadeh S.K., Abi Ghanem D., Haddad J.J., and Safieh-Garabedian B.: Immunopotentiation in chicken layers by

thymulin, thymopoeitin and zinc. Proceedings of the 46th

Western Poultry Conference, - , Sacramento, California,

USA).

Haddad J.J., and Land S.C.: Differential activation of oxygen-responsive transcription factors over fetal-to-neonatal alveolar

oxygen tensions in rat fetal distal lung epithelial cells. The Journal of Physiology (London), 517P: 91P, 1999 (Manchester,

England, UK).

Haddad J.J.: Antioxidant and redox regulation of gene transcription in vitro over fetal-to-neonatal oxygen tensions: Intracellular

HIF- and NF-B differential activation. The 8th

Postgraduate Research Symposium, 8: 12P-13P, 1999 (Dundee, Scotland,

UK).

Haddad J.J., Safieh-Garabedian B.H., Saadé N.E., and Land S.C.: Reactive oxygen species-dependent induction of IL- , IL-6

and TNF- in the alveolar epithelium. The FASEB Journal, 14: A358, 2000 (San Diego, California, USA).

Haddad J.J., Olver R.E., Murphie H.M., and Land S.C.: Redox-mediated differential expression of signaling factors involved in

apoptosis in the perinatal lung. The FASEB Journal, 14: A582, 2000 (San Diego, California, USA).

Haddad J.J., Olver R.E., and Land S.C.: Antioxidant/pro-oxidant equilibrium modulates the redox sensitivity of the alveolar

epithelium: Kinematics of glutathione oxidation-mediated inhibition of HIF- and NF-B. The FASEB Journal, 14: A585,

2000 (San Diego, California, USA).

Haddad J.J.: Immunopharmacological properties of glutathione revealed: Redox disequilibrium and chemioxyexcitation

(pO /ROS) regulation of cytokines in the alveolar epithelium. The 9th

Postgraduate Research Symposium, 9: 43P, 2000

(Dundee, Scotland, UK).

Haddad J.J., Land S.C., Olver R.E., Safieh-Garabedian B., and Saadé N.E.: Redox disequilibrium and chemioxyexcitation

(pO /ROS) mediated regulation of the cytokine network in the alveolar epithelium. Acta Physiologica Scandinavica, 170:

A105-106, 2001 (Stockholm, Sweden).

Haddad J.J., Saadé N.E., Safieh-Garabedian B., and Land S.C.: The immunoregulatory potential of thymulin-Zn

is cAMP-

sensitive and mediated by selective targeting of the redox-sensitive transcription factor NF-B in the alveolar epithelium. The

Journal of Physiology (London), 531P: 177P, 2001 (London, England, UK).

Haddad J.J., Olver R.E., and Land S.C.: The ex vivo differential expression of apoptosis signaling co-factors in the developing

perinatal lung. The FASEB Journal, 15: A82, 2001 (Orlando, Florida, USA).

Haddad J.J., Saadé N.E., Safieh-Garabedian B., and Land S.C.: Thiol regulation of pro-inflammatory cytokines in

lipopolysaccharide-induced alveolar epithelial cells. The FASEB Journal, 15: A162, 2001 (Orlando, Florida, USA).

Haddad J.J., Safieh-Garabedian B., Saadé N.E., and Land S.C.: The involvement of a NF-B-dependent pathway in regulating

pro-inflammatory cytokine biosynthesis in the alveolar epithelium. The FASEB Journal, 15: A162, 2001 (Orlando, Florida,

USA).

Haddad J.J., Safieh-Garabedian B., Saadé N.E., and Land S.C.: Exogenous rmTNF- and redox-sensitive transcription factors

HIF- and NF-B: Up-regulation of endogenous pro- and anti-inflammatory cytokine biosynthesis and involvement of an IB-

dependent pathway. The FASEB Journal, 15: A162, 2001 (Orlando, Florida, USA).

Haddad J.J.: O -dependent regulation of redox-sensitive transcription factors HIF- and NF-B: Signaling potential of

apoptosis and an association between oxidative stress and pro-inflammatory cytokines. The 10th

Postgraduate Research

Symposium, 10: 31P-32P, 2001 (Dundee, Scotland, UK).

Haddad J.J., and Land S.C.: N-[1-(4-{[4-(pyrimidin-2-yl)piperazin-1-yl]methyl}phenyl)cyclopropyl] acetamide, (Y-40138), is a

novel dual regulator of pro- and anti-inflammatory cytokines. 1, Involvement of an interleukin (IL)-10 sensitive pathway. Genes

and Immunity, 2: A175, 2001 (Berlin, Germany).

Haddad J.J., and Land S.C.: Y-40138 is a novel dual regulator of pro- and anti-inflammatory cytokines. 2, Requirement for an

IB-/NF-B signal transduction sensitive pathway. Genes and Immunity, 2: A17 , 2001 (Berlin, Germany).

Haddad J.J., and Land S.C.: Mitogen-activated protein kinase selective regulation of pro-inflammatory cytokines in the alveolar

epithelium. The Biochemical Society Transactions, A55, 2001 (Bristol, England, UK).

Safieh-Garabedian B., Haddad J.J., Jabbur S.J., and Saadé N.E.: Regulation of the nuclear factor B (NF-B) translocation by

intracerebroventricular (ICV) endotoxin and its modulation by thymulin. The Journal of Neuroimmunology, 118 (1): 30, 2001

(Edinburgh, Scotland, UK).

Fahlman C.S., Haddad J.J., Schuyler J.A., and Bickler P.E.: Differential induction by hypoxia of MAPKp38

and MAPKERK

signaling. Society for Neuroscience Abstracts, , (Orlando, Florida, USA).



Haddad J.J., Schuyler J.A., Fahlman C.S., and Bickler P.E.: Hypoxia induces up-regulation of the JNK and ERK but not p38

MAPK pathways in anoxia-tolerant turtle cortex. Society for Neuroscience Abstracts, , (Orlando, Florida, USA).

Peer-Reviewed Publications in Specialized Journals, Documented as of the Academic Year of – Periodically Updated

All citations if and where applicable are technically based on the acclaimed Thomson reference for journal citations – Institute for

Scientific Information; ISI – The official websites are: http://www.isiwebofknowledge.com/; http://highwire.stanford.edu/; and

http://www.scopus.com/.

Manuscripts Published in 1996

Kanaan S., Saadé N.E., Haddad J.J., Abdelnoor A.M., Atweh S.F., Jabbur S.J., and Safieh-Garabedian B.: Endotoxin-induced

local inflammation and hyperalgesia in rats and mice: A new model for inflammatory pain. Pain, (2-3): 373 – ,

(Cited in papers) – MedLine (PubMed) Cross-reference PMID: 8880861 (Publisher: Elsevier

http://www.sciencedirect.com/).

Safieh-Garabedian B., Jalakhian R.H., Saadé N.E., Haddad J.J., Jabbur S.J., and Kanaan S.A.: Thymulin reduces hyperalgesia

induced by peripheral endotoxin injection in rats and mice. Brain Research, (1-2): 179 – , . (Cited in papers) –

MedLine (PubMed) Cross-reference PMID: 8738269 (Publisher: Elsevier http://www.sciencedirect.com/).


Kanaan S.A., Safieh-Garabedian B., Haddad J.J., Atweh S.F., Abdelnoor A.M., Jabbur S.J., and Saadé N.E.: Effects of various

analgesic and anti-inflammatory drugs on endotoxin-induced hyperalgesia in rats and mice. Pharmacology, (6): 285 – ,

(Cited in papers) – MedLine (PubMed) Cross-reference PMID: 9286812 (Publisher: http://www.karger.com/).

Safieh-Garabedian B., Kanaan S.A., Haddad J.J., Abou Jaoude P., Jabbur S.J., and Saadé N.E.: Involvement of interleukin- ,

nerve growth factor and prostaglandin-E in endotoxin-induced localized inflammatory hyperalgesia. The British Journal of

Pharmacology, (8): 1619 – , (Cited in papers) – MedLine (PubMed) Cross-reference PMID: 9283695

(Publisher: http://www3.interscience.wiley.com/).


Barbour E.K., Hamadeh S.K., Abi Ghanem D., Haddad J.J., and Safieh-Garabedian B.: Humoral and cell-mediated

immunopotentiation in vaccinated chicken layers by thymic hormones and zinc. Vaccine, (17): 1650 – , MedLine

(PubMed) Cross-reference PMID: 9713942 (Publisher: Elsevier http://www.sciencedirect.com/).

Kreydiyyeh S., Haddad J.J., and Safieh-Garabedian B.: Interleukin- inhibits the intestinal transport of [

C]3-O-

methylglucose in the rat. Life Sciences, (21): 1913 – , (Cited in papers). MedLine (PubMed) Cross-reference

PMID: 9825769 (Publisher: Elsevier http://www.sciencedirect.com/).


Haddad J.J., and Land S.C.: O -evoked regulation of HIF- and NF-B in perinatal lung epithelium requires glutathione

biosynthesis. The American Journal of Physiology – Lung Cellular and Molecular Physiology, (3): L492 – L503, 2000. This

article is recognized with high access and input on the journal’s website. (Cited in 12 papers) – MedLine

(PubMed) Cross-reference PMID: 10710521 (Publisher: http://ajplung.physiology.org/).

Haddad J.J., and Land S.C.: The differential expression of apoptosis factors in the alveolar epithelium is redox sensitive and

requires NF-B (RelA)-selective targeting. Biochemical and Biophysical Research Communications, (1): 257 – ,



Haddad J.J., Olver R.E., and Land S.C.: Antioxidant/pro-oxidant equilibrium regulates HIF- and NF-B redox sensitivity:

Evidence for inhibition by glutathione oxidation in alveolar epithelial cells. The Journal of Biological Chemistry, (28):

21130 – , This article is recognized with high access and input on the journal’s website. (Cited in

papers) – MedLine (PubMed) Cross-reference PMID: 10801793 (Publisher: http://www.jbc.org/).

http://www.isiwebofknowledge.com/

http://highwire.stanford.edu/

http://www.scopus.com/

http://www.sciencedirect.com/


http://www.karger.com/

http://www3.interscience.wiley.com/



http://ajplung.physiology.org/


http://www.jbc.org/



Haddad J.J., Land S.C., Saadé N.E., and Safieh-Garabedian B.: Immunomodulatory potential of thymulin-Zn

in the alveolar

epithelium: Amelioration of endotoxin-induced cytokine release and partial amplification of a cytoprotective IL-10-sensitive

pathway. Biochemical and Biophysical Research Communications, (2): 500 – , (Cited in papers) – MedLine


Haddad J.J.: Glutathione depletion is associated with augmenting a pro-inflammatory signal: Evidence for an antioxidant/pro-

oxidant mechanism regulating cytokines in the alveolar epithelium. Cytokines, Cellular and Molecular Therapy, (4); 177 –

, . – MedLine (PubMed) Cross-reference PMID: 11565956 (Publisher: http://www.tandf.co.uk/).

Land S.C., Haddad J.J., and Darakhshan F.: Oxygen signaling in perinatal lung development. Comparative Biochemistry and

Physiology Part B: Biochemistry and Molecular Biology, (1); S58, 2000. – MedLine (PubMed) Cross-reference PMID:

(Publisher: Elsevier http://www.sciencedirect.com/).

Manuscripts Published in

Haddad J.J., Safieh-Garabedian B., Saadé N.E., Kanaan S.A., and Land S.C.: Chemioxyexcitation (pO /ROS)-dependent

release of IL- , IL-6 and TNF-: Evidence of cytokines as oxygen-sensitive mediators in the alveolar epithelium. Cytokine,

(3): 138 – , (Cited in papers) – MedLine (PubMed) Cross-reference PMID: 11161456 (Publisher:

Elsevier http://www.sciencedirect.com/).

Haddad J.J., Choudhary K.K., and Land S.C.: The ex vivo differential expression of apoptosis signaling cofactors in the

developing lung: Essential role of oxygenation during the transition from placental to pulmonary-based respiration. Biochemical

and Biophysical Research Communications, (2): 311 – , . (Cited in papers) – MedLine (PubMed) Cross-

reference PMID: 11181047 (Publisher: Elsevier http://www.sciencedirect.com/).

Haddad J.J., Safieh-Garabedian B., Saadé N.E., and Land S.C.: Thiol regulation of pro-inflammatory cytokines reveals a novel

immunopharmacological potential of glutathione in the alveolar epithelium. The Journal of Pharmacology and Experimental

Therapeutics, (3): 996 – , (Cited in papers) – MedLine (PubMed) Cross-reference PMID: 11181934 (Publisher:

http://jpet.aspetjournals.org/).

Haddad J.J., Lauterbach R., Saadé N.E., Safieh-Garabedian B., and Land S.C.: -Melanocyte-related tripeptide, lys-D-pro-val,

ameliorates endotoxin-induced nuclear factor-B translocation and activation: Evidence for involvement of an interleukin- -

receptor antagonism in the alveolar epithelium. The Biochemical Journal, 355 (1): 29 – , – MedLine (PubMed) Cross-

reference PMID: 11256945 (Publisher: http://www.biochemj.org/).

Haddad J.J., Collett A., Land S.C., Olver R.E., and Wilson S.C.: NF-B blockade reduces the O -evoked rise in Na+

conductance in fetal alveolar cells. Biochemical and Biophysical Research Communications, (4): 987 – , . (Cited in

papers) – MedLine (PubMed) Cross-reference PMID: 11237760 (Publisher: Elsevier http://www.sciencedirect.com/).

Baines D.L., Ramminger S.J., Collet A., Haddad J.J., Best O.G., Olver R.E., Land S.C., and Wilson S.M.: Oxygen-evoked Na+

transport in rat fetal distal lung epithelial cells. The Journal of Physiology (London), (1): 105 – , (Cited in

papers) – MedLine (PubMed) Cross-reference PMID: 11283228 (Publisher: http://jp.physoc.org/).

Haddad J.J., Safieh-Garabedian B., Saadé N.E., and Land S.C.: The biphasic immunoregulation of pyrimidylpiperazine (Y-

40138) is IL-10 sensitive and requires NF-B targeting in the alveolar epithelium. The British Journal of Pharmacology,

(1): 49 – , (Cited in papers) – MedLine (PubMed) Cross-reference PMID: 11325794 (Publisher:

http://www3.interscience.wiley.com/).

Haddad J.J., and Land S.C.: Nuclear factor (NF)-B blockade attenuates but does not abrogate lipopolysaccharide-dependent

tumor necrosis factor (TNF)- biosynthesis in alveolar epithelial cells. Biochemical and Biophysical Research

Communications, (2): 267 – , (Cited in papers) – MedLine (PubMed) Cross-reference PMID: 11444836 (Publisher: Elsevier http://www.sciencedirect.com/).

Haddad J.J.: Reduction-oxidation mediated regulation of MAPKp38

-dependent pro-inflammatory cytokine biosynthesis: On the

mechanism of glutathione as a novel immunoregulatory antioxidant thiol. International Archives of Bioscience, (1): 1001 – ,

– (Publisher: http://www.iabs.us/).


http://www.tandf.co.uk/




http://jpet.aspetjournals.org/

http://www.biochemj.org/


http://jp.physoc.org/



http://www.iabs.us/



Haddad J.J.: VX-745, a novel MAPKp38

inhibitor with anti-inflammatory actions (Vertex Pharmaceuticals). Current Opinion in

Investigational Drugs, (8): 1070 – , (Cited in papers) – MedLine (PubMed) Cross-reference PMID: 11892915 (Publisher: http://www.biomedcentral.com/).

Haddad J.J., and Land S.C.: A non-hypoxic, ROS-sensitive pathway mediates TNF--dependent regulation of HIF- .

Federation of European Biochemical Societies (FEBS) Letters, (2): 269 – , This article is recognized with high

access and input on the journal’s website. (Cited in papers) – MedLine (PubMed) Cross-reference PMID:


Haddad J.J.: L-Buthionine-(S,R)-sulfoximine, an irreversible inhibitor of -glutamylcysteine synthetase, augments pro-

inflammatory cytokine biosynthesis: Evidence for the implication of an IB-/NF-B insensitive pathway. European Cytokine

Network, (4): 614 – , (Cited in papers) – MedLine (PubMed) Cross-reference PMID: 11781188 (Publisher:

http://www.john-libbey-eurotext.fr/).

Haddad J.J.: Oxygen-sensitive pro-inflammatory cytokines, apoptosis signaling and redox-responsive transcription factors in

development and pathophysiology. Cytokines, Cellular and Molecular Therapy, (1): 1 – , (Cited in papers) –

MedLine (PubMed) Cross-reference PMID: 12171246 (Publisher: http://www.tandf.co.uk/).


Haddad J.J., and Land S.C.: Amiloride blockades lipopolysaccharide-induced cytokine biosynthesis in an IB-/NF-B-

dependent mechanism: Evidence for the amplification of an anti-inflammatory pathway in the alveolar epithelium. The American

Journal of Respiratory Cell and Molecular Biology, (1): 114 – , (Cited in papers) – MedLine (PubMed) Cross-

reference PMID: 11751211 (Publisher: http://ajrcmb.atsjournals.org/).

Haddad J.J., Saadé N.E., and Safieh-Garabedian B.: Redox regulation of TNF- biosynthesis: Augmentation by irreversible

inhibition of -glutamylcysteine synthetase and the involvement of an IB-/NF-B-independent pathway in alveolar epithelial

cells. Cellular Signalling, (3): 211 – , (Cited in papers) – MedLine (PubMed) Cross-reference PMID: 11812649 (Publisher: Elsevier http://www.sciencedirect.com/).

Haddad J.J., Land S.C., Tarnow-Mordi W.O., Zembala M., KowaLczyk D., and Lauterbach R.: Immunopharmacological

potential of selective phosphodiesterase inhibition. I. Differential regulation of lipopolysaccharide-mediated pro-inflammatory

cytokine (interleukin-6 and tumor necrosis factor-) biosynthesis in alveolar epithelial cells. The Journal of Pharmacology and

Experimental Therapeutics, (2): 559 – , . This article is recognized with high access and input on the journal’s

website. (Cited in papers) – MedLine (PubMed) Cross-reference PMID: 11805217 (Publisher: http://jpet.aspetjournals.org/).

Haddad J.J., Land S.C., Tarnow-Mordi W.O., Zembala M., KowaLczyk D., and Lauterbach R.: Immunopharmacological

potential of selective phosphodiesterase inhibition. II. Evidence for the involvement of an inhibitory-B/nuclear factor-B-

sensitive pathway in alveolar epithelial cells. The Journal of Pharmacology and Experimental Therapeutics, (2): 567 –

, . (Cited in papers) – MedLine (PubMed) Cross-reference PMID: (Publisher: http://jpet.aspetjournals.org/).

Haddad J.J., and Land S.C.: Redox/ROS regulation of lipopolysaccharide-induced mitogen-activated protein kinase (MAPK)

activation and MAPK-mediated TNF- biosynthesis. The British Journal of Pharmacology, (2): 520 – , This

article is recognized with high access and input on the journal’s website. (Cited in papers) – MedLine (PubMed) Cross-

reference PMID: 11815388 (Publisher: http://www3.interscience.wiley.com/).

Haddad J.J.: The involvement of L--glutamyl-L-cysteinyl-glycine (glutathione/GSH) in the mechanism of redox signalling

mediating MAPKp38

-dependent regulation of pro-inflammatory cytokine production. Biochemical Pharmacology, (2): 305 –

, This article is recognized with high access and input on the journal’s website. (Cited in papers) –


Haddad J.J., and Fahlman C.S.: Nuclear factor-B-independent regulation of lipopolysaccharide-mediated interleukin-6

biosynthesis. Biochemical and Biophysical Research Communications, (4): 1045 – , . (Cited in papers) –


Haddad J.J., and Land S.C.: Redox signaling-mediated regulation of lipopolysaccharide-induced pro-inflammatory cytokine

biosynthesis in alveolar epithelial cells. Antioxidants and Redox Signaling, (1): 179 – , (Cited in papers) –

MedLine (PubMed) Cross-reference PMID: 11970852 (Publisher: http://www.liebertonline.com/).

http://www.biomedcentral.com/


http://www.john-libbey-eurotext.fr/

http://www.tandf.co.uk/

http://ajrcmb.atsjournals.org/







http://www.liebertonline.com/



Safieh-Garabedian B., Poole S., Haddad J.J., Massaad C.A., Jabbur S.J., and Saadé N.E.: The role of the sympathetic efferents in

endotoxin-induced localized inflammatory hyperalgesia and cytokine up-regulation. Neuropharmacology, (6): 864 – ,

– MedLine (PubMed) Cross-reference PMID: 12015213 (Publisher: Elsevier http://www.sciencedirect.com/).

Haddad J.J.: Recombinant TNF- mediated regulation of the IB-/NF-B signaling pathway: Evidence for the enhancement of

pro- and anti-inflammatory cytokines in alveolar epithelial cells. Cytokine, (6): 301 – , (Cited in papers) –


Haddad J.J.: Nuclear factor (NF)-B blockade attenuates but does not abrogate LPS-mediated interleukin (IL)- biosynthesis

in alveolar epithelial cells. Biochemical and Biophysical Research Communications, (1): 252 – , . (Cited in

papers) – MedLine (PubMed) Cross-reference PMID: 12054592 (Publisher: Elsevier http://www.sciencedirect.com/).

Haddad J.J.: Oxygen homeostasis, thiol equilibrium and redox regulation of signaling transcription factors in the alveolar

epithelium. Cellular Signalling, (10): 799 – , . (Cited in papers) – MedLine (PubMed) Cross-reference PMID:


Haddad J.J.: Recombinant human interleukin (IL)- -mediated regulation of hypoxia-inducible factor- (HIF- )

stabilization, nuclear translocation and activation requires an antioxidant/reactive oxygen species (ROS)-sensitive mechanism.

European Cytokine Network, (2): 250 – , (Cited in papers) – MedLine (PubMed) Cross-reference PMID:

(Publisher: http://www.john-libbey-eurotext.fr/).

Haddad J.J.: Redox regulation of pro-inflammatory cytokines and IB-/NF-B nuclear translocation and activation.

Biochemical and Biophysical Research Communications, (4): 847 – , (Cited in papers) – MedLine (PubMed)

Cross-reference PMID: 12200125 (Publisher: Elsevier http://www.sciencedirect.com/).

Haddad J.J.: Antioxidant and prooxidant mechanisms in the regulation of redox(y)-sensitive transcription factors. Cellular

Signalling, (11): 879 – , This article is recognized with high access and input on the journal’s website.



Haddad J.J.: Pharmaco-redox regulation of cytokine-related pathways: From receptor signaling to pharmacogenomics. Free

Radical Biology and Medicine, (7): 907 – , (Cited in papers) – MedLine (PubMed) Cross-reference PMID:


Haddad J.J., and Fahlman C.S.: Redox and oxidant-mediated regulation of interleukin-10: An anti-inflammatory, antioxidant

cytokine? Biochemical and Biophysical Research Communications, (2): 163 – , . (Cited in papers) – MedLine


Haddad J.J.: Cytokines and related receptor-mediated signaling pathways. Biochemical and Biophysical Research


Haddad J.J., Safieh-Garabedian B., Saadé N.E., and Lauterbach R.: Inhibition of glutathione-related enzymes augments LPS-

mediated cytokine biosynthesis: Involvement of an IB/NF-B-sensitive pathway in the alveolar epithelium. International

Immunopharmacology, (11): 1567 – , (Cited in papers) – MedLine (PubMed) Cross-reference PMID: 12433058 (Publisher: Elsevier http://www.sciencedirect.com/).

Haddad J.J., Saadé N.E., and Safieh-Garabedian B.: Cytokines and neuro-immune-endocrine interactions: A role for the

hypothalamic-pituitary-adrenal revolving axis. The Journal of Neuroimmunology, (1-2): 1 – ,



Haddad J.J.: Redox and oxygen-sensitive transcription factors in the regulation of oxidant-mediated lung injury. I. Role for

nuclear factor-B. Critical Care, (5): 481 – , (Cited in papers) – MedLine (PubMed) Cross-reference PMID:

(Publisher: http://www.biomedcentral.com/).

Commentary: Craig K., and Dorscheid D.: Understanding the roles of the transcription factors nuclear factor-κB and hypoxia-

inducible factor- α in lung injury. Critical Care, : 471 –





http://www.john-libbey-eurotext.fr/












Citation: Recognized by the World Intellectual Property Organization (http://www.wipo.int/) in the patent (WO/2007/002895)

entitled “Integrative framework for three stage integrative pathway search,” submitted by the board of trustees of Michigan State

University, Michigan, USA (www.msu.edu).

Haddad J.J.: Oxygen sensing mechanisms and the regulation of redox-responsive transcription factors in development and

pathophysiology. Respiratory Research, (1): 26 – , . This article is recognized with high access and input on the

journal’s website. (Cited in papers) – MedLine (PubMed) Cross-reference PMID: 12537605 (Publisher:

http://www.biomedcentral.com/).


Haddad J.J.: Redox and oxygen-sensitive transcription factors in the regulation of oxidant-mediated lung injury. II. Role for

hypoxia-inducible factor- . Critical Care, (1): 47 – , (Cited in papers) – MedLine (PubMed) Cross-reference

PMID: 12617740 (Publisher: http://www.biomedcentral.com/).

Citation: Recognized by the World Intellectual Property Organization (http://www.wipo.int/) in the patent (WO/2007/002895)

entitled “Integrative framework for three stage integrative pathway search,” submitted by the board of trustees of Michigan State

University, Michigan, USA (www.msu.edu).

Haddad J.J., Saadé N.E., and Safieh-Garabedian B.: Interleukin-10 and the regulation of mitogen-activated protein kinases: Are

these signaling modules targets for the anti-inflammatory action of this cytokine? Cellular Signalling, (3): 255 – ,

(Cited in 2 papers) – MedLine (PubMed) Cross-reference PMID: 12531424 (Publisher: Elsevier



Haddad J.J.: Oxygen sensing and oxidant/redox-related pathways. Biochemical and Biophysical Research Communications,

(4): 969 – , (Cited in papers) – MedLine (PubMed) Cross-reference PMID: 15044079 (Publisher: http://www.sciencedirect.com/).

Haddad J.J.: Redox and oxidant-mediated regulation of apoptosis signaling pathways: Immuno-pharmaco-redox conception of

oxidative siege versus cell deal commitment. International Immunopharmacology, (4): 475 – , . (Cited in papers) –


Haddad J.J.: Mitogen-activated protein kinases and the evolution of Alzheimer’s: A revolutionary neurogenetic axis for

therapeutic intervention? Progress in Neurobiology, (5): 359 – , (Cited in papers) – MedLine (PubMed) Cross-


Haddad J.J.: Hypoxia and the regulation of mitogen-activated protein kinases: Gene transcription and the assessment of

potential pharmacologic therapeutic interventions. International Immunopharmacology, (10-11), 1249 – , (Cited in

papers) – MedLine (PubMed) Cross-reference PMID: (Publisher: Elsevier http://www.sciencedirect.com/).

Haddad J.J.: On the antioxidant mechanisms of Bcl-2: A retrospective of NF-B signaling and oxidative stress. Biochemical and

Biophysical Research Communications, (2): 355 – , (Cited in papers) – MedLine (PubMed) Cross-reference

PMID: 15325238 (Publisher: Elsevier http://www.sciencedirect.com/).

Haddad J.J.: Alcoholism and neuro-immune-endocrine interactions: Physiochemical aspects. Biochemical and Biophysical

Research Communications, (2): 361 – , (Cited in papers) – MedLine (PubMed) Cross-reference PMID:


Safieh-Garabedian B., Haddad J.J., and Saadé N.E.: Cytokines in the central nervous system: Targets for therapeutic

intervention. Current Drug Targets – CNS & Neurological Disorders, (4): 271 – , – MedLine (PubMed) Cross-

reference PMID: 15379603 (Publisher: http://www.bentham.org/).


Haddad J.J.: Amiloride and the regulation of NF-B: An unsung crosstalk and missing link between fluid dynamics and

oxidative stress-related inflammation – controversy or pseudo-controversy? Biochemical and Biophysical Research


http://www.wipo.int/

http://www.msu.edu/



http://www.wipo.int/

http://www.msu.edu/









http://www.bentham.org/




Haddad J.J., and Harb H.L.: Cytokines and the regulation of hypoxia-inducible factor- . International Immunopharmacology,

(3): 461 – , (Cited in papers) – MedLine (PubMed) Cross-reference PMID: 15683844 (Publisher: Elsevier


Haddad J.J., and Harb H.L.: L--Glutamyl-L-cysteinyl-glycine (glutathione; GSH) and GSH-related enzymes in the regulation of

pro- and anti-inflammatory cytokines: A signaling transcriptional scenario for redox(y) immunologic sensor(s)? Molecular

Immunology, (9): 987 – , (Cited in papers) – MedLine (PubMed) Cross-reference PMID: 15829290 (Publisher:


Haddad J.J., Saadé N.E., and Safieh-Garabedian B.: Thymulin: An emerging anti-inflammatory molecule. Current Medicinal

Chemistry – Anti-inflammatory and Anti-allergy Agents, (3): 333 – , (Publisher: http://www.bentham.org/).

Haddad J.J.: N-Methyl-D-aspartate and the regulation of MAPK signaling pathways: A revolving neurochemical axis for

therapeutic intervention? Progress in Neurobiology, (4): 252 – , (Cited in papers) – MedLine (PubMed) Cross-



Haddad J.J.: On the enigma of pain and hyperalgesia: A molecular perspective. Biochemical and Biophysical Research

Communications, (2): 217 – , (Cited in 2 papers) – MedLine (PubMed) Cross-reference PMID: 17184730 (Publisher: Elsevier http://www.sciencedirect.com/).

Haddad J.J.: The role of Bax/Bcl-2 and pro-caspase peptides in hypoxia/reperfusion-dependent regulation of MAPKERK

:

Discordant proteomic effect of MAPKp38

. Protein and Peptide Letters, (4): 361 – , – MedLine (PubMed) Cross-

reference PMID: 17504094 (Publisher: http://www.bentham.org/).

Haddad J.J.: Discordant tissue-specific expression of SAPK/MAPKJNK

-related cofactors in hypoxia and hypoxia/reoxygenation

in a model of anoxia-tolerance. Protein and Peptide Letters, (4): 373 – , . – MedLine (PubMed) Cross-reference

PMID: 17504095 (Publisher: http://www.bentham.org/).

Haddad J.J.: Cellular and molecular regulation of inflammatory pain, nociception and hyperalgesia – The role of the

transcription factor NF-B as the lynchpin nocisensor: Hyperalgesic or analgesic effect? Current Immunology Reviews, (2):

117 – , . (Publisher: http://www.bentham.org/).

Samaha A.A., Ivanov A.V., Haddad J.J., Kolesnik A.I., Baydoun S., Yashina I.N., Samaha R.A., and Ivanov D.A.:

Biomechanical and system analysis of the human femoral bone: Correlation and anatomical approach. Journal of Orthopedic

Surgery and Research, (5): 8 – , . – MedLine (PubMed) Cross-reference PMID: (Publisher:

http://www.biomedcentral.com/).


Samaha A.A., Hatoum H., Abou Ghazal F., Mattar H., Itany O.S., and Haddad J.J.: A case study with breast cancer and brain

metastasis encompassing acute onset of amnesia and altered mental status due to limbic encephalitis – Biochemical and

proteomic aspects. Experimental and Clinical Sciences Journal, : 132 – 138, 2008. (Publisher: http://www.excli.de/).

Samaha A.A., Ivanov A.V., Haddad J.J., Baydoun S., Arabi M.R., Yashina I.N., Kolesnik A.I., Samaha R.A., and Ivanov D.A.:

Asymmetry and structural system analysis of the proximal femur meta-epiphysis: Osteoarticular anatomical pathology. Journal

of Orthopedic Surgery and Research, (2): 11 – , . – MedLine (PubMed) Cross-reference PMID:

(Publisher: http://www.biomedcentral.com/).

Haddad J.J.: On the mechanisms and putative pathways involving neuroimmune interactions. Biochemical and Biophysical

Research Communications, (4): 531 – , – MedLine (PubMed) Cross-reference PMID: 18413144 (Publisher:


Haddad J.J.: The regulation of neuroimmune-endocrine interactions: Mechanisms, molecular pathways unraveled and the

pivotal role of cytokines – A unsung putative bidirectional interdependence between the immune and neuroendocrine interfaces.

Current Immunology Reviews, (3): 134 – , . (Publisher: http://www.bentham.org/).










http://www.excli.de/







Samaha A.A., Nasser-Eddine W., Shatila E., Haddad J.J., Wazne J., and Eid A.H.: Multi-organ damage induced by anabolic

steroid supplements: Case report and literature review. Journal of Medical Case Reports, : 340 – , –

MedLine (PubMed) Cross-reference PMID: 18976461 (Publisher: http://www.biomedcentral.com/).

Haddad J.J.: The role of inflammatory cytokines and NF-B/MAPK signaling pathways in the evolution of familial

Mediterranean fever: Current clinical perspectives and potential therapeutic approaches. Cellular Immunology, (1): 6 – ,

. – MedLine (PubMed) Cross-reference PMID: (Publisher: Elsevier http://www.sciencedirect.com/).

Haddad JJ.: Endotoxin-mediated regulation of nuclear factor-B nuclear translocation and activation in the hippocampus of the

central nervous system: modulation by intracerebroventricular treatment with thymulin and the immunomodulatory role of the

IB-/pIB- pathway. Neuroscience, ( ): – , . – MedLine (PubMed) Cross-reference PMID: TBA (Publisher: Elsevier http://www.sciencedirect.com/).


Haddad J.J.: Thymulin and zinc (Zn

)-mediated inhibition of endotoxin-induced production of proinflammatory cytokines and

NF-B nuclear translocation and activation in the alveolar epithelium: Unraveling the molecular immunomodulatory, anti-

inflammatory effect of thymulin/Zn

in vitro. Molecular Immunology, (1): 205 – , . – MedLine (PubMed) Cross-

reference PMID: (Publisher: Elsevier http://www.sciencedirect.com/).


Haddad J.J.: A redox microenvironment is essential for MAPK-dependent secretion of pro-inflammatory cytokines: Modulation

by glutathione (GSH/GSSG) biosynthesis and equilibrium in the alveolar epithelium. Cellular Immunology, (1): 53 – ,

– MedLine (PubMed) Cross-reference PMID: TBA (Publisher: Elsevier http://www.sciencedirect.com/).

Haddad J.J., and Abdel-Karim N.E.: NF-B cellular and molecular regulatory mechanisms and pathways: Therapeutic pattern

or pseudoregulation? Cellular Immunology, (1): 5 – , – MedLine (PubMed) Cross-reference PMID: TBA (Publisher: Elsevier http://www.sciencedirect.com/).

Haddad J.J.: The immunopharmacologic potential of semaxanib and new generation directed therapeutic drugs: Receptor

tyrosine kinase regulation with anti-tumorigenesis/angiogenesis properties. Saudi Pharmaceutical Journal, In press, –

MedLine (PubMed) Cross-reference PMID: TBA (Publisher: Elsevier http://www.sciencedirect.com/).

Manuscripts Submitted for Publication in Specialized Journals, Documented as of

Haddad J.J.: Regulatory neuroimmune mechanisms and putative pathways. Progress in Neurobiology, .

Samaha A.A., Ivanov A.V., Arabi M.R., Yashina I.N., Samaha R.A., Termos S.H., Ivanov D.A., and Haddad J.J.: Structural

peculiarities of the proximal femur meta-epiphysis in the idiopathic coxarthrosis according to localization. Journal of

Orthopedic Surgery and Research, .

Haddad J.J.: Glutathione and cancer: A glimpse of the immunotherapeutic efficacy of an antioxidant. Biochemical and

Biophysical Research Communications, .

Haddad J.J.: Amalgamation of glutathione and MAPKp38

pathways in the oxidant regulation of TNF-α secretion n alveolar

epithelial cells. European Cytokine Network, .

Haddad J.J.: Interactive NMDA signaling modules: Are MAPKs lynchpins? Current Medicinal Chemistry, .

Manuscripts in Preparation for Consideration for Publication in Specialized Journals, Documented as of

Haddad J.J.: Glutathione and cancer: A glimpse of the immunotherapeutic efficacy of an antioxidant. Biochemical and

Biophysical Research Communications, .










Haddad J.J.: Redox and oxidant-dependent regulatory mechanisms in apoptosis revisited. Biochemical and

Biophysical Research Communications,

Samaha A.A., and Haddad J.J.: Case report: A 51 year old lady under warfarin complicated by gastric ulcer and jejunal

hematoma. Journal of Medical Case Reports, .

Haddad J.J.: On the molecular mechanisms of deciphering the anthrax code. International Immunopharmacology, .

Saadé N.E., Haddad J.J., and Safieh-Garabedian B.: NF-B-mediated regulation of nociception in a model of inflammatory

hyperalgesia and neuropathic pain in the rat. Proceedings of the National Academy of Sciences USA, .

Haddad J.J.: An interactive mitogen-activated protein kinase and nitric oxide crosstalk in neurodegeneration: A neurochemical

axis for therapeutic intervention? Experimental Neurology, .

Haddad J.J.: Glutathione oxidation and GSSG-mediated regulation of transcription factors. The International Journal of

Biochemistry and Cell Biology, .

CURRENT AND ONGOING RESEARCH

The immunomodulatory potential of thymulin-Zn

(Collaboration with the American University of Beirut, Beirut, Lebanon).

The role of mitogen-activated protein kinase in LPS-induced pro-inflammatory cytokines and NF-B signaling

(Collaboration with the University of California, San Francisco, USA).

Regulation of redox-sensitive transcription factors by pro-inflammatory cytokines (Collaboration with the University of

California, San Francisco, USA).

Purinergic regulation of pro-inflammatory cytokines (Collaboration with the University of California, San Francisco, USA).

Adrenoreceptor regulation of pro-inflammatory cytokines (Collaboration with the University of California, San Francisco,

USA).

Immunomodulatory potential of histamine and the cytokine network (Collaboration with the University of California, San

Francisco, USA and the American University of Beirut, Beirut, Lebanon).

Thiol regulation of pro-inflammatory cytokines and redox-sensitive transcription factors (Collaboration with the University

of California, San Francisco, USA and the American University of Beirut, Beirut, Lebanon).

Phosphodiesterases and pro-inflammatory cytokines (Collaboration with the American University of Beirut, Beirut, Lebanon,

the University of Sydney, Sydney, Australia and the Jagiellonian University Medical College, Cracow, Poland).

Hypoxia-mediated regulation of MAPK and apoptosis signaling (Collaboration with the University of California, San

Francisco, USA).

The involvement of neuroprotection mechanisms in NMDA and Ca

-mediated regulation of MAPK signaling pathways

(Collaboration with the University of California, San Francisco, USA).

The regulation of MAPK signaling in anoxia-tolerant turtles (Collaboration with the University of California, San Francisco,

USA).

The regulation of MAPK signaling under the influence of anesthetics (Collaboration with the University of California, San

Francisco, USA).

Domestic and International Collaborations

American University of Beirut (AUB) – AUB is one of the most prestigious academic institution in the Middle East

and operates directly under charter from New York State – (Professor Nayef E. Saadé (Ph.D.; D.Sc.), chairman of the

department of Human Morphology at the School of Medicine).

American University of Beirut (AUB) – (Professor Bared Safieh-Garabedian (Ph.D.), faculty member of the department of

Biology and an honorary professor at the Institute of Cellular and Molecular Sciences, Queen Mary University of London,

UK).

University of Dundee (UoD) – UoD is an accredited academic institution in Scotland, affiliated with Saint Andrews

University, founded in the 14th

century A.D. – (Professor John D. Hayes (Ph.D.), chairman of the Higher Degrees

Committee and faculty at the Biomedical Research Center BRC at Ninewells Hospital and Medical School It’s noteworthy

to mention that Professor John Hayes is a collaborator of Sir Professor David Lane (Ph.D.), who discovered the mutated gene,

p53, the prevalence of which causes pervasive cancer.

Jagiellonian University Medical College, Cracow, Poland – (Professor Ryszard Lauterbach (M.D., Ph.D.), faculty member

of the department of Neonatology).

University of California, San Francisco (UCSF) – UCSF is rated amongst the top 10 university hospitals and medical

schools in the United States – (Professor Teiji Sawa (M.D., Ph.D.), faculty member of the department of Microbiology at

UCSF School of Medicine).

University of California, San Francisco (UCSF) – (Professor Donald M. Taylor (M.D., Ph.D.), faculty member of the

department of Anesthesia and Perioperative Care at UCSF School of Medicine).



Journal Citations Impact Factors, According to ISI, Alphabetically Arranged as of 200 (Periodically Updated)

The American Journal of Physiology – Lung Cellular and Molecular Physiology ISI .

The American Journal of Respiratory Cell and Molecular Biology ISI 4.

Antioxidant and Redox Signaling ISI 3.763

Biochemical and Biophysical Research Communications ISI .

Biochemical Journal ISI 4.

Biochemical Pharmacology ISI 3.617

Brain Research ISI .

The British Journal of Pharmacology ISI 3.410

Cellular Immunology ISI

Cellular Signalling ISI

Comparative Biochemistry and Physiology Part B – Cellular and Molecular Biology ISI 1.4

Critical Care ISI 2.93

Current Drug Targets – CNS and Neurological Disorders ISI 4.900

Current Medicinal Chemistry – Antiinflammatory and Anti-allergy Agents ISI 4.900

Cytokine ISI

European Cytokine Network ISI 1.073

FEBS Letters ISI

Free Radical Biology and Medicine ISI .

International Immunopharmacology ISI

The Journal of Biological Chemistry ISI 7.385

Journal of Medical Case Reports ISI 1.416

Journal of Neuroimmunology ISI .

The Journal of Pharmacology and Experimental Therapeutics ISI 7.064

The Journal of Physiology (London) ISI

Life Sciences ISI

Molecular Immunology ISI

Neuroscience ISI 3.358

Pain ISI

Pharmacology ISI 2.961

Progress in Neurobiology ISI

Protein and Peptide Letters ISI 1.840

Respiratory Research ISI 2.68

Vaccine ISI

Chapters, Textbooks, Dissertations and Encyclopedias, Documented as of

Haddad J.J.: Hyperalgesia induced by local endotoxin injections and its modulation by various anti-inflammatory and

analgesic drugs. Master of Science (M.Sc.) Thesis, pp. 1-67, 1996 (American University of Beirut, Beirut, Lebanon and New

York City, New York, USA).

Saadé N.E., Kanaan S.A., Haddad J.J., Atweh S.F., Jabbur S.J., and Safieh-Garabedian B.: Dissociation between peripheral

and central components of endotoxin (ET)-induced hyperalgesia. In: Pain Mechanisms and Management (Eds. A.V.

Apkarian and S. Ayrapetian). IOS Press, Amsterdam, Ohmsha, pp. 120- ,

Haddad J.J.: O -dependent regulation of redox-sensitive transcription factors HIF- and NF-B in the developing

perinatal lung: Signaling potential of apoptosis and an association between oxidative stress and pro-inflammatory cytokines.

Doctor of Philosophy (Ph.D.) Thesis, pp. 1- , 2001 (University of Dundee [in affiliation with Saint Andrews University,

St. Andrews, Scotland], Dundee, Scotland, UK).

Haddad J.J.: The role of mitogen-activated protein kinase signaling pathways in determining death and survival in hypoxic

neurons. Postdoctoral Research Paper, pp. 1-35, 2003 (University of California, San Francisco, California, USA).

Haddad J.J.: The emphatic role of Mitogen-activated protein kinases in Alzheimer’s disease. In: Current Research on

Alzheimer’s Disease (Ed. N. Columbus). Nova Science Publishers, Hauppauge, NY, USA, 2007.



Haddad J.J.: Alcoholism and neuroimmune-endocrine interactions: Physiochemical aspects. In: Research on Neurobiology

of Alcohol Use Disorders (Ed. N. Columbus). Nova Science Publishers, Hauppauge, NY, USA,

Haddad J.J.: Transcriptional regulation of inflammatory pain and hyperalgesia. In: Scirus Topic Pages. Elsevier,

(http://scitopics.com/Transcriptional_regulation_of_inflammatory_pain_and_hyperalgesia_NF_kB_as_a_lynchpin_and_mast

er_regulator.html).

Haddad J.J.: Neuroimmunology. In: Encyclopedia of Neuroscience (Eds.: M.D. Binder, N. Hirokawa, U. Windhorst, and

M.C. Hirsch; pp. 1- separate volumes]). Springer-Verlag GmbH Berlin Heidelberg, Heidelberg, pp. 2527- ,

(http://refworks.springer.com/neuroscience; ISBN: 978- - - - ).

About the Encyclopedia: Unique in its breadth and detail, this encyclopedia offers a comprehensive and highly readable

guide to a complex and fast-expanding field. The five-volume reference work gathers more than 10,000 entries, including in-

depth essays by internationally known experts, and short keynotes explaining essential terms and phrases. In addition, expert

editors contribute detailed introductory chapters to each of 43 topic fields ranging from the fundamentals of neuroscience to

fascinating developments in the new, inter-disciplinary fields of Computational Neuroscience and Neurophilosophy. Some

1,000 multi-color illustrations enhance and expand the writings. This user-friendly reference will be indispensable to basic

and clinical scientists and practitioners in academia, hospitals, private practice, and industry, as a source of reliable

information on the structure and function of the nervous system. The Encyclopedia of Neuroscience opens the topic to health

care professionals, students, teachers and informed laypersons who require relevant information on this rapidly evolving

field. (Adapted, courtesy of the publisher’s website: www.springer.com)

Haddad J.J., et al.: The Molecular Biology of Pain. (Ed.: J.J. Haddad). Bentham Publishers (www.bentham.org), In

preparation, .

http://scitopics.com/Transcriptional_regulation_of_inflammatory_pain_and_hyperalgesia_NF_kB_as_a_lynchpin_and_master_regulator.html

http://scitopics.com/Transcriptional_regulation_of_inflammatory_pain_and_hyperalgesia_NF_kB_as_a_lynchpin_and_master_regulator.html

http://refworks.springer.com/neuroscience

http://www.springer.com/




ACADEMIC AND INDUSTRIAL REFERENCES

Professor Nayef E. Saadé, Ph.D., D.Sc.

Chairman and Professor of Neurobiology and Physiology

Department of Human Morphology

Medical School, Faculty of Medicine

American University of Beirut (AUB), Beirut, Lebanon

Telephone: ( ) - -

Extensions

Fax: -

E-mail: [email protected]

Professor Bared Safieh-Garabedian, Ph.D.

Professor of Neurobiology and Biochemistry

Institute of Cell and Molecular Sciences

Queen Mary University of London, London, UK

Department of Biology

Faculty of Arts and Sciences

American University of Beirut (AUB), Beirut, Lebanon

Telephone: - -

( ) -

Extensions

Fax: -


Professor Martin Frank, Ph.D.

Executive Director and Professor

The American Physiological Society (APS)

9650 Rockville Pike, Bethesda, Maryland 20814, USA

Telephone: -

Fax: -


Professor Nabil Haidar, Ph.D.

Provost and Vice President for International Affairs

American University of Science and Technology (AUST),

Aschrafieh, Beirut, Lebanon

Telephone: - /

Extensions: /

Fax: -


Professor Nadim Karam, M.D., Ph.D.

Dean and Professor of Internal Medicine

Faculty of Health Sciences

University of Balamand (UoB), Balamand, Beirut, Lebanon

Telephone: - /

Extension:

Fax: -


Dr. Irfan Rahman, Ph.D.

Associate Professor of Environmental Medicine

Department of Environmental Medicine

Lung Biology and Disease Program

University of Rochester Medical Center

Rochester, NY 14642, USA

Telephone: + -

Fax: + -


Professor Jihad Attieh, Ph.D.

Dean and Professor

Faculty of Sciences

University of Balamand (UoB), Balamand, El-Koura, Tripoli,

Lebanon

Telephone: -

Extension

Fax: ( ) -

E-mail: [email protected] [email protected]

Professor Shihadeh Nayfeh, Ph.D.

Provost and Executive Vice President and Professor

American University of Technology (AUT), Byblos, Lebanon

Telephone: ) -

Extension:

Fax: ( ) -













Abridged Academic Curriculum Vitae

O B J E C TI VE

R&D Biomedical Research, Laboratory Management and Development (Academy and Industry); Administrative/Professorship Tutoring and

Teaching (Academy).

E DUC A TI ON

Postdoctoral, University of California, San Francisco, CA, USA—2003 Ph.D., University of Dundee, Dundee, Scotland, UK—2001 M.Sc., American University of Beirut, Beirut, Lebanon—1996

B.Sc., American University of Beirut, Beirut, Lebanon—1992

A WA R D S , F E L L O WS HI P S , G R A N T S

University of California—Postdoctoral (NIH) fellowship University of Dundee—Ph.D. fellowship American University of Beirut—M.Sc. & B.Sc. Fellowships

P O SI T IO N S HE L D

February, 2009—Current, Professor American University of Science and Technology

January, 2006—February, 2009, Chairman of the University

Research Council Lebanese International University

October, 2006—February, 2009, Associate Professor Lebanese International University

October, 2004—September, 2006, Associate Professor

Lebanese International University

October, 2005—Current, Lecturer University of Balamand

February, 2005—Janaury, 2006, Lecturer American University of Science and Technology

September, 2003—February, 2005, Lecturer Haigazian University

P UB LIC A TI ON S

As per unabridged academic curriculum vitae

CO N F E R E NC E P R E S E N TA T IO N S

As per unabridged academic curriculum vitae

RE F E R E N C E S Martin Frank, Execuitve Director, American Physiological Society, USA Irfan Rahman, Associate Professor, University of Rochester, USA Bared Safieh-Garabedian, Professor, Queen Mary University of London, UK Jihad Attieh, Dean and Professor, University of Balamand, Lebanon

Department of Clinical Laboratory Sciences Faculty of Health Sciences

University of Balamand Aschrafieh, Beirut, Lebanon

Phone: 961 (1) 562-108/9 Fax: 961 (1) 562-110


Dr. John J. Haddad

john j. haddad - weeblyjohnjhaddad.weebly.com › uploads › 2 › 5 › 2 › 0 ›...

Documents