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The Journal of the British Thoracic Society

1 Duration of chemotherapy in small cell lung cancer S G Spiro, R L Souhami

Original articles

Molecular biology andrespiratory disease

AIDS and the lung

Short reports

Letters to the editor

3 Immunosuppression by pulmonary surfactant: mechanisms of action M L Wilsher, D J Parker,P L Haslam

9 Serum leucine-enkephalin in bronchial carcinoma and its relation to tumour location J R Gosney,MA Gosney, M Lye

12 Morphological integrity of the bronchial epithelium in mild asthma S Lozewicz, C Wells, E Gomez,H Ferguson, P Richman, J Devalia, R J Davies

16 Almitrine bismesylate and oxygen therapy in hypoxic cor pulmonale T W Evans, J Tweney,J C Waterhouse, J Nichol, A J Suggett, P Howard

22 Decline of the lung function related to the type of tobacco smoked and inhalation P Lange, S Groth,J Nyboe, J Mortensen, M Appleyard, G Jensen, P Schnohr

27 Effects of passive smoking on the pulmonary function of adults M-R Masjedi, H Kazemi, D C Johnson32 Decline of lung function and development of chronic airflow limitation: a longitudinal study of

non-smokers and smokers in Busselton, Western Australia J K Peat, A J Woolcock, K Cullen38 Effect of fibreoptic bronchoscopy on pulmonary function A J Peacock, R Benson-Mitchell, R Godfrey42 Effect of y aminobutyric acid on the carbon dioxide rebreathing response of normal subjects: a study using

vigabatrin A G Fennerty, EM Rimmer, J Boulton, A Richens45 Mycobacterial infection in patients infected with the human immunodeficiency virus M Helbert,

D Robinson, D Buchanan, T Hellyer,M McCarthy, I Brown, A J Pinching, DM Mitchell49 AIDS and UK respiratory.physicians: attitudes to confidentiality, infection control, and management

S Church, S Owen, A A Woodcock

52 1-Basic principles C A Owen, R A Stockley

57 4-Non-invasive investigation of pulmonary disease in patients positive for the human immunodeficiencyvirus A B Millar, D M Mitchell

62 5-Tests giving an aetiological diagnosis in pulmonary disease in patients infected with the humanimmunodeficiency virus R F Miller, T R Leigh, J V Collins, D M Mitchell

66 Lobar collapse due to endobronchial metastatic prostatic carcinoma: re-expansion with antiandrogentreatment H Taylor, S Braude

68 Haemothorax caused by a solitary costal exostosis J R Reynolds, E Morgan70 Diffuse meningeal thickening associated with pleural mesothelioma J B Murray, J B Neilly, D Hadley,

F Moran, M McKean72 Necrotising pneumonia and empyema due to Clostridium perfringens complicating pulmonary embolus

Y Bashir, MK Benson74 A case of necrobacillosis A J Chippindale, B Patel, H Mamtora76 Obstructive sleep apnoea due to a dermoid cyst of the floor of the mouth J M Goldman, D J Barnes,

D V Pohl77 Effect of chest physiotherapy on oxygen saturation in patients with cystic fibrosis J A Pryor, B A Webber,

ME Hodson

78 Role of histamine release in hypertonic saline induced bronchoconstriction J P Finnerty; S P O'Hickey78 Fall in peak expiratory flow during haemodialysis in patients with chronic renal failure P G Wu,

IK P Cheng, WK Lam; A J Williams, A Davenport79 Topical nasal anaesthesia for fibreoptic bronchoscopy B R O'Driscoll, J R Webb; J Efthimiou,

T Higenbottam; A R Webb, F J C Millard79 Disturbance in respiratory mechanics in infants with bronchiolitis S Godfrey79 Adverse effect of additional weight on exercise against gravity in patients with chronic obstructive airways

disease A J France; C R Swinburn, P A Corris, G J Gibson

80 Book notices

BRITISH MEDICAL ASSOCIATION TAVISTOCK SQUARE LONDON WC1H 9JR

JANUARY 1990 VOL 45 No 1

Editorial

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VOLUME 45 * CONTENTS

No 1 JANUARY 1990 Page Editorial1 Duration of chemotherapy in small cell lung cancer S G Spiro, R L Souhami

Original articles3 Immunosuppression by pulmonary surfactant: mechanisms of action M L Wilsher, D J Parker, P L Haslam9 Serum leucine-enkephalin in bronchial carcinoma and its relation to tumour location J R Gosney,M A Gosney,M Lye

12 Morphological integrity of the bronchial epithelium in mild asthma S Lozewicz, C Wells, E Gomez, H Ferguson,P Richman, J Devalia, R J Davies

16 Almitrine bismesylate and oxygen therapy in hypoxic cor pulmonale T W Evans, J Tweney, J C Waterhouse,J Nichol, A J Suggett, P Howard

22 Decline of the lung function related to the type of tobacco smoked and inhalation P Lange, S Groth, J Nyboe,J Mortensen, M Appleyard, G Jensen, P Schnohr

27 Effects of passive smoking on the pulmonary function of adults M-R Masjedi, H Kazemi, D C Johnson32 Decline of lung function and development of chronic airflow limitation: a longitudinal study of non-smokers and

smokers in Busselton, Western Australia J K Peat, A J Woolcock, K Cullen38 Effect of fibreoptic bronchoscopy on pulmonary function A J Peacock, R Benson-Mitchell, R Godfrey42 Effect of y aminobutyric acid on the carbon dioxide rebreathing response of normal subjects: a study using

vigabatrin A G Fennerty, EM Rimmer, J Boulton, A Richens45 Mycobacterial infection in patients infected with the human immunodeficiency virusM Helbert, D Robinson,

D Buchanan, T Hellyer,M McCarthy, I Brown, A J Pinching, DM Mitchell49 AIDS and UK respiratory physicians: attitudes to confidentiality, infection control, and management S Church,

S Owen, A A Woodcock

Molecular biology and respiratory disease52 1-Basic principles C A Owen, R A Stockley

AIDS and the lung57 4-Non-invasive investigation of pulmonary disease in patients positive for the human immunodeficiency virus

A B Millar, D M Mitchell62 5-Tests giving an aetiological diagnosis in pulmonary disease in patients infected with the human

immunodeficiency virus R F Miller, T R Leigh, J V Collins, DM MitchellShort reports

66 Lobar collapse due to endobronchial metastatic prostatic carcinoma: re-expansion with antiandrogen treatmentH Taylor, S Braude

68 Haemothorax caused by a solitary costal exostosis J R Reynolds, E Morgan70 Diffuse meningeal thickening associated with pleural mesothelioma J B Murray, J B Neilly, D Hadley, F Moran,

M McKean72 Necrotising pneumonia and empyema due to Clostridium perfringens complicating pulmonary embolus Y Bashir,

M K Benson74 A case of necrobacillosis A J Chippindale, B Patel, HMamtora76 Obstructive sleep apnoea due to a dermoid cyst of the floor of the mouth JM Goldman, D J Barnes, D V Pohl77 Effect of chest physiotherapy on oxygen saturation in patients with cystic fibrosis J A Pryor, B A Webber,

M E Hodson

Letters to the editor78 Role of histamine release in hypertonic saline induced bronchoconstriction J P Finnerty; S P O'Hickey Fall in

peak expiratory flow during haemodialysis in patients with chronic renal failure P G Wu, IK P Cheng, WK Lam;A J Williams, A Davenport Topical nasal anaesthesia for fibreoptic bronchoscopy B R O'Driscoll, J R Webb;J Efthimiou, T Higenbottam; A R Webb, F J C Millard Disturbance in respiratory mechanics in infants withbronchiolitis S Godfrey Adverse effect of additional weight on exercise against gravity in patients with chronicobstructive airways disease A J France; C R Swinburn, P A Corns, G J GibsonMiscellaneous

80 Book notice

No 2 FEBRUARY 1990 Editorial81 Management of malignant pleural effusionsMHN Tattersall,M J Boyer

For discussion83 BCG vaccination of schoolchildren in England and Wales VH Springett, I Sutherland

Original articles89 Relation between small airways disease and parenchymal destruction in surgical lung specimens LN A Willems,

J A Kramps, T Stijnen, P J Sterk, J J Weening, JH Dijkman95 Reduced selenium in asthmatic subjects in New Zealand A Flatt, N Pearce, C D Thomson, M R Sears,

M F Robinson, R Beasley100 In vitro and in vivo effects of ribavirin on human respiratory epithelium L Y Han, R Wilson, S Slater, A Rutman,

R C Read, NJ C Snell, P J Cole105 Pulmonary y interferon production in patients with fibrosing alveolitis B WS Robinson, A H Rose109 Particle size of beclomethasone dipropionate produced by two nebulisers and two spacing devices C O'Callaghan112 Corticosteroid trials in non-asthmatic chronic airflow obstruction: a comparison of oral prednisolone and inhaled

beclomethasone dipropionate D C Weir, R I Gove, A S Robertson, P Sherwood Burge118 Time course of response to oral and inhaled corticosteroids in non-asthmatic chronic airflow obstruction D C Weir,

A S Robertson, R I Gove, P Sherwood Burge122 Diagnosis of congenital cystic adenomatoid malformation of the lung in newborn infants and childrenHA Heij,

S Ekkelkamp, A Vos



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126 Pulmonary sequelae in survivors of congenital diaphragmatic hernia A R Falconer, R A Brown, P Helms, I Gordon,J A Baron

130 Changes in hospital management of acute severe asthma by thoracic and general physicians in Birmingham andManchester during 1978 and 1985 D R Baldwin, L P Ormerod, A D Mackay, D E Stableforth

135 Comparison of thin section computed tomography with bronchography for identifying bronchiectatic segments inpatients with chronic sputum production N C Munro, J C Cooke, D C Currie, B Strickland, P J ColeAIDS and the lung

140 6-Management of respiratory failure in patients with the acquired immune deficiency syndrome and Pneumocystiscarinii pneumonia R F Miller, D M MitchellMolecular biology and respiratory disease

147 2-Applications to the study and treatment of respiratory disease: methods in molecular biology C A Owen,R A Stockley

Short reports154 Primary malignant fibrous histiocytoma of the mediastinum W J Morshuis, A L Cox, L K Lacquet,M Mravunac,

J 0 Barentsz156 Systemic amyloid associated with carcinoma of the bronchus I Richmond, P S Hasleton, S Samadian

Letters to the editor158 Alveolitis associated with sulphamethoxypyridazine I Lenox-Smith; J S Friedland, J C Porter, E Wojnarowska,

J G G Ledingham Significance of antibodies to cytoplasmic components of neutrophils B Rudensky, J Ashkenazi,A Abramov,M Isacsohn Effect of inhaled leukotriene B4 alone and in combination with prostaglandin D2 onbronchial responsiveness to histamine in normal subjectsM Adachi, T Imai, T Takahashi Pulmonaryeosinophilia I W B Grant

Miscellaneous159 Book notices; Notice

No 3 MARCH 1990 Editorial161 What is the role of the eosinophil? P Venge

Respiratory medicine and the Third World164 Tobacco and the Third World J Crofton

Original articles170 Case-control study of prescribed fenoterol and death from asthma in New Zealand, 1977-81 N Pearce, J Grainger,

M Atkinson, J Crane, C Burgess, C Culling, H Windom, R Beasley176 Why are hospital admission and mortality rates for childhood asthma higher in New Zealand than in the United

Kingdom? E A Mitchell, H R Anderson, P Freeling, P T White183 Nutritional state of patients with lung cancer undergoing thoracotomy Y Bashir, T R Graham, A Torrance,

G J Gibson, P A Corris187 Nosocomial lower respiratory tract infections in surgical wards W JM Kinnear, R G Finch, R Pilkington,

I T Macfarlane190 Assessment of reversibility of airway obstruction in patients with chronic obstructive airways diseaseM Nisar,

M Walshaw, J E Earis,M G Pearson, PM A Calverley195 Long term domiciliary oxygen treatment for chronic respiratory failure reviewed S V Baudouin, J C Waterhouse,

T Tahtamouni, J A Smith, J Baxter, P Howard199 Does the outcome of the tidal breathing and dosimeter methods of assessing bronchial responsiveness in children

with asthma depend on age? D Birnie, G W S thoe Schwartzenberg, W C J Hop, E EM van Essen-Zandvliet,K F Kerrebijn

203 Occupational asthma due to tea dust A Cartier, J-L Malo207 Cough threshold after upper abdominal surgery J P Dilworth, J C Pounsford, R J White210 Unilateral post-tuberculous lung destruction: the left bronchus syndromeM Ashour, L Pandya, A Mezratyi,

W Qutashat,M Desouki,N Al-Sharif, A Al-Jaboori, A MarieNew drugs review

213 Potassium channels and airway function: new therapeutic prospects J L Black, P J Barnes

AIDS and the lung219 7-Treatment of lung disease in patients with the acquired immune deficiency syndrome D M Mitchell,

M A JohnsonMolecular biology and respiratory disease

225 3-Evaluation of nucleolar organiser regions in pulmonary pathologyM J Egan, J CrockerShort reports

233 Sericulturist's lung disease: hypersensitivity pneumonitis related to silk production T Nakazawa, Y Umegae235 Non-cardiogenic pulmonary oedema due to the intravenous administration of clove oil CM Kirsch, G G Yenokida,

W A Jensen, R Wendland,H Suh,M BourgaultConference report

237 Sixteenth annual meeting of the European Working Group for Cystic fibrosis D J ShaleLetters to the editor

239 Chickenpox pneumonia: an association with pregnancy S J Rogerson, F J Nye,N J Beeching; J Esmonde,G Anderson, G Herdman Sedation for fibreoptic bronchoscopy A C Davidson, R Leach,N T Bateman * Postpneumonectomy pulmonary oedema M MargolisMiscellaneous

239 Book notice

Correction240 Decline of the lung function related to the type of tobacco smoked and inhalation (P Lange et al)



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No 4 APRIL 1990

No 5 MAY 1990

Original articles241 Respiratory failure and sleep in neuromuscular disease P T P Bye, E R Ellis, F G Issa, P M Donnelly, C E Sullivan248 Changes in regional ventilation and perfusion of the lung after endoscopic laser treatment P J M George, G Clarke,

S Tolfree, C P 0 Garrett, M R Hetzel254 A hospital study of community acquired pneumonia in the elderly P Venkatesan, J Gladman, J T Macfarlane,

D Barer, P Berman, W Kinnear, R G Finch259 Formoterol, a new long acting beta2 agonist for inhalation twice daily, compared with salbutamol in the treatment of

asthma A Wallin, B Melander, L Rosenhall, T Sandstrom, L Wdhlander262 Effects of exercise on gas exchange in patients recovering from acute severe asthma G E Packe, W Freeman,

R M Cayton267 Hard metal asthma: cross immunological and respiratory reactivity between cobalt and nickel? T Shirakawa,

Y Kusaka, N Fujimura, M Kato, S Heki, K Morimoto272 Bronchoscopic and bronchographic findings in 12 patients with sarcoidosis and severe or progressive airways

obstruction Z F Udwadia, J R Pilling, P F Jenkins, B D W Harrison276 Effect of bacterial products on neutrophil migration in vitro G Ras, R Wilson, H Todd, G Taylor, P Cole281 Production of interleukin-l like activity by neutrophils derived from rat lung Y Kusaka, K Donaldson

AIDS and the lung283 AIDS, ethics, and the respiratory physicianM Brazier, M Lobjoit

Personal view287 Behavioural breathlessness J B L Howell

Short reports293 Intracardiac ectopic thyroid: a case report and review of published cases I Richmond, J S Whittaker,

A K Deiraniya, R Hassan295 Cyclosporin treatment in rapidly progressive pulmonary thromboembolic Behcet's disease J F Vansteenkiste,

P Peene, J A Verschakelen, K P van de Woestijne297 Lung abscess secondary to xanthogranulomatous pyelonephritis K Pandya, J Wilcox,H Khaw, D Cleveland,

O P Sharma298 Primary liposarcoma of the lung in a young woman F Ruiz-Palomo, J L Calleja, L Fogue300 Subglottic stenosis in Wegener's granulomatosis: development during cyclophosphamide treatment with response

to carbon dioxide laser therapy C Strange, L Halstead,M Baumann, S A Sahn301 Book notice

Letters to the editor302 Diagnosis of pulmonary disease in human immunodeficiency virus infection: role of transbronchial biopsy and

bronchoalveolar lavage G di Perri, R Luzzati,M Malena, M Cruciani, E Concia, D Bassetti, A Cazzadori;MH Griffiths, G Kocjan, R F Miller Diaphragmatic paresis: pathophysiology, clinical features, and investigationCM Laroche,M Green; G J Gibson

Miscelianeous303 Notices

Proceedings304 British Thoracic Society winter meeting 1989

Original articles345 Benefits and problems of a physical training programme for asthmatic patients L M Cochrane, C J Clark352 Dependence of maximal sniff generated mouth and transdiaphragmatic pressures on lung volume T Wanke,

G Schenz,H Zwick, W Popp, L Ritschka,M Flicker356 Relation of urinary cotinine concentrations to cigarette smoking and to exposure to other people's smoke

S G Thompson, R Stone, K Nanchahal,N J Wald362 Effects of an inhaled corticosteroid, budesonide, on alveolar macrophage function in smokers H Bergstrand,

A Bjornson, E Blaschke, R Brattsand, A Eklund,K Larsson,M Linden369 Pleuroperitoneal shunt for recurrent malignant pleural effusions V Tsang,H C Fernando, P Goldstraw373 Value of washings and brushings at fibreoptic bronchoscopy in the diagnosis of lung cancer VHF Mak,

I D A Johnston,M R Hetzel, C Grubb377 Effect of inhaled frusemide on the early response to antigen and subsequent change in airway reactivity in atopic

patients P Verdiani, S Di Carlo, A Baronti, S Bianco382 Quantification of airborne moulds in the homes of children with and without wheeze D P Strachan, B Flannigan,

EM McCabe, F McGarry388 Effect of chronic airflow limitation on resting oxygen consumption C Lanigan, J Moxham, J Ponte391 Expression of surface antigens distinguishing "naive" and previously activated lymphocytes in bronchoalveolar

lavage fluid S Dominique, F Bouchonnet, J-M Smiijan, A J Hance397 Prospective study of mycobacterial infections in patients with cystic fibrosis L Hjelte, B Petrini, G Kdllenius,

B Strandvik401 Concentrations of cefixime in bronchial mucosa and sputum after three oral multiple dose regimens D R Baldwin,

JM Andrews, J P Ashby, R Wise, D HoneybourneGuidelines

403 Chemotherapy and management of tuberculosis in the United Kingdom: recommendations of the JointTuberculosis Committee of the British Thoracic Society L P Ormerod

Molecular biology and respiratory disease409 4-Cancer genes K Sikora, G Ong

Short reports414 Transcarinal needle aspiration in the diagnosis of mediastinal adenitis in a patient infected with the human

immunodeficiency virus G J Serdai, F R de Castro, JM F Sdnchez-Alarcos, J C Luna, F D L6pez, P C Navarro416 Choriocarcinoma with lung metastases during pregnancy with successful delivery and outcome after chemotherapy

J Nabers, T A W Splinter,H C S Wallenburg, F J W ten Kate,_R Qosterom, C Hilverini419 Exacerbation of isoniazid induced peripheral neuropathy by pyndoxineM Nisar, S W Watkin, R C Bucknall,

R A L Agnew



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420 Recurrent isolated alternating phrenic nerve palsies: a variant of brachial neuritis? R P Gregory, L Loh,J Newsome-Davis

422 Unsuspected myasthenia gravis presenting as respiratory failure A Mier, C Laroche,M Green

Letters to the editor424 Repeatability of ventilatory function measurements in a population survey of 7 year old children M C S Kennedy;

D P Strachan * Botulism: a potentially common problem P E Slater * The current state of lungtransplantation S K Morcos; P A Corris, JH Dark

No 6 JUNE 1990

No 7 JULY 1990

Editorial425 Physiology and treatment of cough R W Fuller, DM Jackson

Original articles431 Trends and district variations in the hospital care of childhood asthma: results of a regional study 1970-85

HR Anderson438 Time course of change in oxygen saturation and peak expiratory flow in children admitted to hospital with acute

asthma W Mihatsch, G C Geelhoed, L I Landau, PN LeSouef442 Clinical correlates of angiographically diagnosed idiopathic pulmonary hypertension HH Gray, JM Morgan,

I H Kerr, G A H Miller447 Controlled trial of natamycin in the treatment of allergic bronchopulmonary aspergillosis D C Currie, C Lueck,

H J Milburn, C Harvey, J L Longbottom, JH Darbyshire, A J Nunn, P J Cole451 Effect of lung T lymphocytes on fibroblasts in idiopathic pulmonary fibrosis and extrinsic allergic alveolitis

M Selman, G Gonzalez, M Bravo, J Sullivan-Lopez, C Ramos,M Montano,N Barquin, F Vadillo456 Changes in pulmonary microvascular permeability accompanying re-expansion oedema: evidence from dual isotope

scintigraphy P D Wilkinson, J Keegan, S W Davies, J Bailey, R M Rudd460 Pulmonary deposition of nebulised pentamidine isethionate: effect of nebuliser type, dose, and volume of fill

M O'Doherty, S Thomas, C Page, C Bradbeer, T Nunan,N Bateman465 Rib cage mechanics after median stemotomy T J Locke, T L Griffiths,H Mould, G J Gibson469 Comparison of bronchodilator responses and deposition patterns of salbutamol inhaled from a pressurised metered

dose inhaler, as a dry powder, and as a nebulised solution B M Z Zainudin,M Biddiscombe, S E J Tolfree,M Short,S G Spiro

474 Local anaesthesia for fibreoptic bronchoscopy: transcricoid injection or the "spray as you go" technique?A R Webb, S S D Fernando, HR Dalton, J E Arrowsmith,MA Woodhead, A R C Cummin

478 Long term continuous domiciliary oxygen therapy by transtracheal catheter D A Walsh, J R Govan

Molecular biology and respiratory disease482 Molecular biology of receptors: implications for lung disease P J Barnes

Short reports489 Mixed allergic bronchopulmonary fungal disease due to Pseudallescheria boydii and Aspergillus F R Lake,

A E Tribe, R McAleer, J Froudist, P J Thomnpson491 Mediastinitis and bilateral thoracic empyemas complicating adult epiglottitis WH Chong,MA Woodhead,

F J C Millard493 Elective resection of tumours of the trachea and main carina after endoscopic laser therapy S Shankar,

P JM George,M R Hetzel, P GoldstrawLetters to the editor

496 Long term survival after pulmonary resection for small cell carcinoma of the lung J-L Pujol, P Demoly,F-B Michel Pulmonary haemorrhage in Henoch-Schonlein purpura D Veale,M C Venning, A Quinn;H S Markus, J V Clark

Miscellaneous481 Book notices * Notices

Original articles497 Effects of lung resection on pulmonary function and exercise capacity C Pelletier, L Lapointe, P LeBlanc503 Bronchography in the assessment of patients with lung collapse for endoscopic laser therapy P JM George,

M C Pearson, D Edwards, R M Rudd,MR Hetzel509 Bronchoscopic cryotherapy for advanced bronchial carcinoma D A Walsh,M 0 Maiwand, A R Nath, P Lockwood,

MH Lloyd,M Saab514 Single breath carbon monoxide transfer factor in different forms of chronic airflow obstruction in a general

population sample R J Knudson, W T Kaltenborn, B Burrows520 Alveolar partial pressures of carbon dioxide and oxygen measured by a helium washout technique J Jordanoglou,

G Tatsis, J Danos, S Gougoulakis, D Orfanidou,M Gaga525 Transfer of 'Tc DTPA and bronchoalveolar lavage findings in patients with asymptomatic extrinsic allergic

alveolitis B Schmekel, P Wollmer, P Venge,M Linden, B Blom-Builow530 Effect on histamine responsiveness of reducing airway dimensions by altering posture Y T Wang, C I Coe,

N B Pride536 Idiopathic pulmonary fibrosis: can cell mediated immunity markers predict clinical outcome? R Meliconi, E Lalli,

R M Borzi, C Sturani, V Galavotti, G Gunella, R Miniero, A Facchini, G Gasbarrini541 Indium-l 11 labelled granulocyte scanning to detect inflammation in the lungs of patients with chronic sputum

expectoration D C Currie, A M Peters,N D Garbett, P George, B Strickland, J P Lavender, P J Cole545 Plasma growth hormone and digital clubbing in carcinoma of the bronchus M A Gosney, J R Gosney,M Lye548 Left ventricular thrombectomy in the early postinfarction period A Smolinsky, Z Ziskind, R Mohr, D A Goor,

M Motro

Molecular biology and respiratory disease552 Modern molecular biology and respiratory bacterial infections: a revolution on the horizon T F Murphy

Conference report560 The Seventh World Conference on Tobacco and Health J Crofton

Short reports563 Massive pleural effusion due to pancreatic pseudocyst A R J Girbes, P E Postmus, W Jansen, E J vd Jagt,

JH Kleibeuker



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565 Sarcoidosis presenting as recurrent left laryngeal nerve palsy F A El-Kassitni,M Ashour, R Vijayaraghavan566 Constrictive pericarditis caused by primary liposarcoma R J Lionarons, J van Baarlen, J F Hitchcock568 Recurrent and fatal haemoptysis caused by an atheromatous abdominal aortic aneurysm M T A Villar, J Wiggins,

B Corrin, T W Evans570 Recurrent localised pneumonia due to bronchial infiltration in a patient with chronic lymphocytic leukaemia

A Desjardins, G Ostiguy, S Cousineau, M GygerLetters to the editor

571 Duration of chemotherapy in small cell lung cancerMH Cullen; R L Souhami, S G Spiro * Diffuse meningealthickening associated with pleural mesotheliomaM Huncharek, J Muscat * Role of histamine released in hypertonicsaline induced bronchoconstriction N P Kearny; S O'Hickey - A case of necrobacillosis J Moore-Gillon, S J EykynMiscellaneous

572 Book notice

No 8 AUGUST 1990 Editorial573 Corticosteroids and osteoporosis R Smith

Original articles579 Relation of ventilatory impairment and of chronic mucus hypersecretion to mortality from obstructive lung disease

and from all causes P Lange, J Nyboe, M Appleyard, G Jensen, P Schnohr586 Distribution of arterial lesions and collateral pathways in the pulmonary hypertension of congenital heart disease: a

computer aided reconstruction study G-y Yaginuma, H Mohri, T Takahashi591 Bronchoalveolar lavage in patients with mild and severe rheumatoid lung disease D M Gilligan, CM O'Connor,

K Ward, D Moloney, B Bresnihan,MX FitzGerald597 Assessment of the right ventricle by magnetic resonance imaging in chronic obstructive lung disease L W Turnbull,

J P Ridgway, W Biernacki, H McRitchie, A L Muir, J J K Best, W MacNee602 Vertical gradients of lung density in supine subjects with fibrosing alveolitis or pulmonary emphysema A B Millar,

D M Denison606 Evidence for protein oedema, neutrophil influx, and enhanced collagen production in lungs of patients with

systemic sclerosis N K Harrison, R J McAnulty, P L Haslam, CM Black, G J Laurent611 Pulmonary function in healthy young adult Indians in Madras V K Vijayan, K V Kuppurao, P Venkatesan,

K Sankaran, R Prabhakar616 Prospective study of the yield of physical examination compared with chest radiography in penetrating thoracic

trauma S R Thomson, WK J Huizinga, A Hirshberg620 Peak expiratory flow at altitude P S Thomas, R M Harding, J S Milledge623 Effect of forced expirations on mucus clearance in patients with chronic airflow obstruction: effect of lung recoil

pressure C P van der Schans, D A Piers,H Beekhuis, G H Koeter, Th W van der Mark, D S Postma628 Suitability of and tolerance to Iotrolan 300 in bronchography via the fibreoptic bronchoscope S K Morcos,

P B Anderson, S V Baudouin, C Clout, N Fairlie, C Baudouin, N Warnock630 Effect of caffeine on histamine bronchoprovocation in asthma A Colacone, L Bertolo, N Wolkove, C Cohen,

H Kreisman633 Sex difference in the inhaled tartaric acid cough threshold in non-atopic healthy subjects M Fujimura, S Sakamoto,

Y Kamio, T Matsuda

Short reports635 Asymptomatic renal thoracic ectopia, pulmonary hypoplasia, and Bochdalek hernia G Hulks,M D Cowan,

J W Kerr637 The biphasic spirogram: a clue to unilateral narrowing of a mainstem bronchus A D Gascoigne, P A Corris,

JH Dark, G J Gibson639 Staphylococcal pneumonia, pneumatoceles, and the toxic shock syndrome A C Davidson, M Creach, I R Cameron641 Unilateral pulmonary oedema in a patient with hypertrophic cardiomyopathy and severe narrowing of the left

pulmonary artery Y Turberg, F J Ricou, J C Chevrolet643 Giant chondroma of the sternum mimicking a mediastinal mass G Fink,M Bergman,M Levy, I Avidor, S Spitzer

Letters to the editor645 Case-control study of prescribed fenoterol and death from asthma in New Zealand, 1977-81 W 0 Spitzer,

A S Buist; N Pearce, J Crane, C Burgess, R Beasley Local anaesthesia for fibreoptic bronchoscopy C Teale,M F Muers, S B Pearson; A C Davidson, R Leach, N T Bateman * BCG vaccination of schoolchildren in Englandand WalesM Nisar, P D 0 Davies * Posture and noctumal asthma B Mossberg, K Larsson; N J Douglas,K F WhyteMiscellaneous

647 Book notices Notices

No 9 SEPTEMBER 1990 Review649 Role of asbestos and other fibres in the development of diffuse malignant mesothelioma A R Gibbs

Editorial655 Pericardial effusion after open heart surgery A J Bryan, G D Angelini

Original articles657 Trends in lung cancer, chronic obstructive lung disease, and emphysema death rates for England and Wales

1941-85 and their relation to trends in cigarette smoking P N Lee, J S Fry, B A Forey666 Comparison of almitrine bismesylate and medroxyprogesterone acetate on oxygenation during wakefulness and

sleep in patients with chronic obstructive lung disease E Daskalopoulou, D Patakas, V Tsara, F Zoglopitis, E Maniki670 Use of biological glue to control pulmonary air leaks A F Matar, J G Hill, WDuncan, N Orfanakis, I Law675 Effects of inflammation and fibrosis on pulmonary function in diffuse lung fibrosis T Chinet, F Jaubert, D Dusser,

C Danel, J Chritien, G JHuchon679 Appropriate and inappropriate neuroendocrine products in pulmonary tumourlets J Gosney, A R T Green,

W Taylor



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684 Plasma cross linked fibrin degradation products in pulmonary embolism B J Rowbotham, J Egerton-Vernon,A N Whitaker, M J Elms, I H Bunce

688 External detection of pulmonary accumulation of indium-i 13 labelled transferrin in the guinea pigU Hultkvist-Bengtsson, L Mdrtensson

694 Prostaglandin F2, enhancement of capsaicin induced cough in man: modulation by beta2 adrenergic andanticholinergic drugs G Nichol, A Nix, P J Barnes, K F Chung

699 Management of recurrent malignant pleural effusion in the United Kingdom: survey of clinical practiceL G McAlpine, G Hulks,N C Thomson

Medical practice702 Use of a management plan for treating asthma in an emergency department I Town, T Kwong, P Holst, R Beasley

Short reports707 The hyperimmunoglobinaemia E and recurrent infections syndrome in an adult J-P L' Huillier, P-H Thoreux,

P Delaval, B Desrues, E Le Gall, J Kernec, J-F Delambre709 Pulmonary disease following intravesical BCG treatment S Kesten, L Title, B Mullen, R Grossman711 Use of a fenestrated silicone drain to stent a malignant tracheobronchial stenosis R L Insall, G N Morritt713 Bronchoalveolar lavage findings in a patient with the organic dust toxic syndrome E Raymenants,M Demedts,

B Nemery715 Effort rupture of the diaphragm B El Nakadi, P Vanderhoeft

Letter to the editor716 Behavioural breathlessness B Gandevia; J Howell

Miscellaneous706 Book notices

No 10 OCTOBER 1990 Editorial717 Alcohol breath testing in patients with respiratory diseaseM J Morris

Original articles722 Pharyngeal shape and dimensions in healthy subjects, snorers, and patients with obstructive sleep apnoea

D 0 Rodenstein, G Dooms, Y Thomas, G Liistro, D C Stanescu, C Culie, G Aubert- Tulkens728 Jet and ultrasonic nebuliser output: use of a new method for direct measurement of aerosol output J H Dennis,

S C Stenton, J R Beach, A J Avery, EH Walters, D J Hendrick733 Use of inhaled corticosteroids in patients with mild asthma S Lorentzson, J Boe, G Eriksson, G Persson736 Do large volume spacer devices reduce the systemic effects of high dose inhaled corticosteroids? P H Brown,

G Blundell, A P Greening, G K Crompton740 Morning serum cortisol concentrations after 2 mg inhaled beclomethasone dipropionate in normal subjects: effect

of a 750 ml spacing device M Farrer, A J Francis, S J Pearce743 Lung function, hypoxic and hypercapnic ventilatory responses, and respiratory muscle strength in normal subjects

taking oral theophylline S Javaheri, L Guerra748 Role of small calibre chest tube drainage for iatrogenic pneumothoraxM Laub, N Milman, D Muller,

E Struve-Christensen750 Respiratory muscle function in cystic fibrosis A Mier, A Redington, C Brophy,M Hodson,M Green

Review articles753 Assisted ventilation: 1- Artificial ventilation: history, equipment, and techniques J D Young,M K Sykes759 Molecular biology and respiratory disease: 7- The a, antitrypsin gene and chronic lung diseaseN Kalsheker,

K MorganNew developments in clinical practice

765 Intraluminal irradiation for the palliation of lung cancer with the high dose rate micro-Selectron P A Burt,B R O'Driscoll, H M Notley, P V Barber, R Stout

Short reports769 Granulomatous Pneumocystis carinii pneumonia in a patient with the acquired immunodeficiency syndrome

H D L Birley, J R Buscombe, M H Griffiths, S J G Semple, R F Miller771 Bronchoalveolar lavage via a modified stomach tube in intubated patients with the acquired immunodeficiency

syndrome and diffuse pneumonia R Minutoli, E Eden, C Brachfeld773 Posterior mediastinal teratoma with abdominal extension S El Kalla,M Abdul-Hameed, A Al Ashbal, N Menon775 Giant lymph node hyperplasia of the lung (Castleman's disease) associated with recurrent pleural effusion

A A Awotedu, B A Otulana, CO Ukoli

Letters to the editor777 Investigation of pulmonary disease in HIV infection P J Flegg, L J Willocks, R P Brettle, A G Bird; A Millar,

D Mitchell; R Miller, T Leigh, J Collins, D Mitchell

Miscellaneous777 Book notices * Notice

Proceedings779 British Thoracic Society summer meeting 1990

No 11 NOVEMBER 1990 Editorial825 Exogenous surfactant treatment for the adult respiratory distress syndrome? A historical perspective N S Morton

Original articles831 Effect of nicotine, silver acetate, and ordinary chewing gum in combination with group counselling on smoking

cessation E J Jensen, E Schmidt, B Pedersen, R Dahl835 Smoking cessation in patients: two further studies by the British Thoracic Society Research Committee of the British

Thoracic Society841 Clearance of '99 Tc DTPA from guinea pig nasal, tracheobronchial, and bronchoalveolar airways L Greiff,

P Wollmer, I Erjefdlt, U Pipkorn, C G A Persson846 Management of post-tuberculous complex aspergilloma of the lung: role of surgical resection S A Al-Majed,

M Ashour, F A El-Kassimi, I Joharjy, A Al-Wazzan, M S Al-Hajjaj, R Vijay



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850 Primary bone tumours of the thoracic skeleton: an audit of the Leeds regional bone tumour registry D A Waller,R J Newman

856 Effect of frusemide on airway smooth muscle contractility in vitro A J Knox, P Ajao860 Bronchial hyperresponsiveness in young students of southern China: relation to respiratory symptoms, diagnosed

asthma, and risk factorsN S Zhong, R C Chen,M 0-yang, J Y Wu, WX Fu, L J Shi866 A general practice based survey ofbronchial hyperresponsiveness and its relation to symptoms, sex, age, atopy, and

smoking C J Trigg, J B Bennett,M Tooley, B Sibbald,M F D'Souza, R J Davies873 A simple method for correcting single breath total lung capacity for underestimation A Loiseau, P Loiseau,

G Saumon878 Collagen of the dystrophic hamster diaphragmN S Al-Zaid,M S Al-Adnani, K A Gumaa

Review articles880 Cystic fibrosis: Introduction D J Shale; 1- Pseudomonas aeruginosa infection in cystic fibrosis and its management

N Hoiby, C Koch885 Assisted ventilation: 2- Indications for mechanical ventilation J Ponte891 Pulmonary complications of intravenous drug misuse: 1- Epidemiology and non-infective complications

C R K Hind

Short reports899 Lung fibrosis induced by Thorotrast P De Vuyst, P Dumortier, P Ketelbant, J Flament-Durand, J Henderson,

J C Yernault901 Adult respiratory distress syndrome after limited resection of adenocarcinoma of the lung S El Bayadi,

D B Ettensohn, J Yashar903 Diffuse alveolar haemorrhage associated with progressive systemic sclerosisM T Griffin, J D Robb, J R Martin905 Eosinophilic granuloma of the lung presenting as a solitary pulmonary nodule C J Fichtenbaum, G M Kleinman,

R G Haddad

Letters to the Editor907 Mycobacterial infection in patients infected with the human immunodeficiency virus P J Horner, D Bell,

S Murphy,M W McNicol; VH Springett, I Sutherland;M Herbert et al * Assessment of reversibility of airwayobstruction in patients with chronic obstructive airways disease D C Weir, P S Burge;M G Pearson,PM A Calverley * Primary liposarcoma of the lung in a young womanMN Sheppard; F Ruiz-Palomo, L FogueMiscellaneous

908 Book notices - NoticeNo 12 DECEMBER 1990 Editorials

909 Management of the solitary metastasis R McIntosh,N Thatcher912 Pulmonary tuberculosis in the elderly: a different disease? C D W Morris

Original articles914 Perception of breathlessness during bronchoconstriction induced by antigen, exercise, and histamine challenges

H Turcotte, F Corbeil, L-P Boulet919 Relation between respiratory symptoms, type of farming, and lung function disorders in farmersM Iversen,

B Pedersen924 Analysis of bronchial reactivity in epidemiological studiesM J Abramson,N A Saunders,M J Hensley930 Bronchodilatation induced by deep breaths in relation to transpulmonary pressure and lung volume C J Duggan,

J Chan, A J Whelan, N Berend935 Modified muscle sparing posterolateral thoracotomyM Ashour939 Inhaled micronised gentamicin powder: a new delivery system JM Goldman, SM Bayston, S O'Connor,

R E Meigh941 Lung function 8-18 years after intermittent positive pressure ventilation for hyaline membrane disease

M JK de Kleine, CM Roos, WJ Voorn,HM Jansen, J G Koppe947 Effects ofhypothyroidism on bronchial reactivity in non-asthmatic subjects S Wieshammer, F S Keck,

A C Schauffelen, H von Beauvais, H Seibold, V Hombach951 Performance and prognosis in patients with lung cancer S Capewell,M F Sudlow on behalf of the Edinburgh Lung

Cancer GroupReview articles

957 Pulmonary complications of intravenous drug misuse: 2- Infective and HIV related complications C R K Hind962 Assisted ventilation: 3- General care of the ventilated patient in the intensive care unitMR Hamilton-Farrel,

G C Hanson970 Cystic fibrosis: 2- Lung injury in cystic fibrosis J S Elborn, D J Shale

Short reports974 Ipecacuanha asthma: an old lesson A Seaton975 Life threatening haemoptysis in cystic fibrosis: an alternative therapeutic approach D Bilton, A K Webb,H Foster,

P Mulvenna, M Dodd976 Intercostal arteriovenous fistula due to pleural biopsy J-H Lai, H-C Yan, S-J Kao, S-C Lee, C-Y Shen978 Chylothorax secondary to obstruction of the superior vena cava: a complication of the LeVeen shunt WH Warren,

J S Altman, S A Gregory980 Occupational asthma in a pharmaceutical worker exposed to hydralazine B Perrin, J-L Malo, A Cartier, S Evans,

J DolovichLetters to the Editor

982 BCG vaccination of schoolchildren in England and Wales S Ahmed, W J Poulsom - Concentrations of cefixime inbronchial mucosa and sputum F P V Maesen, R Costongs, B I Davies; D R Baldwin et al - Clinical correlates ofangiographically diagnosed idiopathic pulmonary hypertension KM Moser, P F Fedullo, W R Auger; H H Gray,J M Morgan* Antemortem recognition of brain metastases in malignant mesothelioma R A Lewis, M Huncharek -

Local anaesthesia for fibreoptic bronchoscopy BR O'Driscoll, P V Barber; Y Kubota, Y Toyoda, H KubotaCorrection

984 The hyperimmunoglobulinaemia E and recurrent infections syndrome in an adultJ-P L'Huillier et alMiscellaneous

981 Book notices985 Main index to Volume 45999 Index of British Thoracic Society abstracts

Contents for 1990



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